Search Site
Advanced Search…
Models Home
Exposures
Documentation
Log in
You are here:
Home
/
Exposures
/
Mackenzie, Loo, Panayotova-Heiermann and Wright, 1996
/
Renal SGLT2 model
Info
Model Mathematics
Component based math viewer is available
Component: environment
Component: parameters
alpha_p
=
1
-
delta
-
alpha_pp
C_T
=
1
e
6
N_C
N_Avo
mu
=
F
V
R
T
Component: ion_concentrations
d
d
time
V
=
100
e
-6
Component: rate_constants
ks_12
=
k0_12
ⅇ
-
n
alpha_p
mu
2
k_12
=
ks_12
Na_o
n
k_21
=
k0_21
ⅇ
n
z_Na
alpha_p
mu
2
k_23
=
k0_23
glucose_o
k_32
=
k0_32
k_34
=
k0_34
ⅇ
-
z_c
+
n
delta
mu
2
k_43
=
k0_43
ⅇ
z_c
+
n
delta
mu
2
k_45
=
k0_45
k_54
=
k0_54_temp
glucose_i
k_25
=
k0_25
ⅇ
-
z_c
+
n
delta
mu
2
k_52_temp
=
k0_52
ⅇ
z_c
+
n
delta
mu
2
k_56
=
k0_56
ⅇ
-
n
z_Na
alpha_pp
mu
2
k_65
=
k0_65
Na_i
n
ⅇ
n
z_Na
alpha_pp
mu
2
k_61
=
k0_61
ⅇ
z_c
delta
mu
2
k_16
=
k0_16
ⅇ
-
z_c
delta
mu
2
k_52
=
k0_12
k_25
k0_56
k0_61
k0_21
k0_16
k0_65
k0_54_temp
=
k0_23
k_34
k_45
k_52
k_43
k_32
k_25
Component: kinetic_equations
d
d
time
C_1
=
k_21
C_2
+
k_61
C_6
-
k_12
+
k_16
C_1
d
d
time
C_2
=
k_12
C_1
+
k_32
C_3
+
k_52
C_5
-
k_21
+
k_23
+
k_25
C_2
d
d
time
C_3
=
k_23
C_2
+
k_43
C_4
-
k_32
+
k_34
C_3
d
d
time
C_4
=
k_34
C_3
+
k_54
C_5
-
k_45
+
k_43
C_4
d
d
time
C_5
=
k_45
C_4
+
k_65
C_6
+
k_25
C_2
-
k_54
+
k_52
+
k_56
C_5
d
d
time
C_6_temp
=
k_16
C_1
+
k_56
C_5
-
k_61
+
k_65
C_6_temp
C_6
=
C_T
-
C_1
+
C_2
+
C_3
+
C_4
+
C_5
Component: king_altman_states
C1_sum
=
k_21
k_32
k_43
k_54
k_65
+
k_21
k_34
k_45
k_52
k_65
+
k_21
k_32
k_45
k_52
k_65
+
k_21
k_32
k_43
k_52
k_65
+
k_25
k_34
k_45
k_56
k_61
+
k_23
k_34
k_45
k_56
k_61
+
k_21
k_34
k_45
k_56
k_61
+
k_25
k_32
k_45
k_56
k_61
+
k_21
k_32
k_45
k_56
k_61
+
k_25
k_32
k_43
k_56
k_61
+
k_21
k_32
k_43
k_56
k_61
+
k_21
k_32
k_43
k_54
k_61
+
k_21
k_34
k_45
k_52
k_61
+
k_21
k_32
k_45
k_52
k_61
+
k_21
k_32
k_43
k_52
k_61
C2_sum
=
k_16
k_32
k_43
k_54
k_65
+
k_12
k_32
k_43
k_54
k_65
+
k_16
k_34
k_45
k_52
k_65
+
k_12
k_34
k_45
k_52
k_65
+
k_16
k_32
k_45
k_52
k_65
+
k_12
k_32
k_45
k_52
k_65
+
k_16
k_32
k_43
k_52
k_65
+
k_12
k_32
k_43
k_52
k_65
+
k_12
k_34
k_45
k_56
k_61
+
k_12
k_32
k_45
k_56
k_61
+
k_12
k_32
k_43
k_56
k_61
+
k_12
k_32
k_43
k_54
k_61
+
k_12
k_34
k_45
k_52
k_61
+
k_12
k_32
k_45
k_52
k_61
+
k_12
k_32
k_43
k_52
k_61
C3_sum
=
k_16
k_25
k_43
k_54
k_65
+
k_12
k_25
k_43
k_54
k_65
+
k_16
k_23
k_43
k_54
k_65
+
k_12
k_23
k_43
k_54
k_65
+
k_16
k_21
k_43
k_54
k_65
+
k_16
k_23
k_45
k_52
k_65
+
k_12
k_23
k_45
k_52
k_65
+
k_16
k_23
k_43
k_52
k_65
+
k_12
k_23
k_43
k_52
k_65
+
k_12
k_23
k_45
k_56
k_61
+
k_12
k_23
k_43
k_56
k_61
+
k_12
k_25
k_43
k_54
k_61
+
k_12
k_23
k_43
k_54
k_61
+
k_12
k_23
k_45
k_52
k_61
+
k_12
k_23
k_43
k_52
k_61
C4_sum
=
k_16
k_25
k_34
k_54
k_65
+
k_12
k_25
k_34
k_54
k_65
+
k_16
k_23
k_34
k_54
k_65
+
k_12
k_23
k_34
k_54
k_65
+
k_16
k_21
k_34
k_54
k_65
+
k_16
k_25
k_32
k_54
k_65
+
k_12
k_25
k_32
k_54
k_65
+
k_16
k_21
k_32
k_54
k_65
+
k_16
k_23
k_34
k_52
k_65
+
k_12
k_23
k_34
k_52
k_65
+
k_12
k_23
k_34
k_56
k_61
+
k_12
k_25
k_34
k_54
k_61
+
k_12
k_23
k_34
k_54
k_61
+
k_12
k_25
k_32
k_54
k_61
+
k_12
k_23
k_34
k_52
k_61
C5_sum
=
k_16
k_25
k_34
k_45
k_65
+
k_12
k_25
k_34
k_45
k_65
+
k_16
k_23
k_34
k_45
k_65
+
k_12
k_23
k_34
k_45
k_65
+
k_16
k_21
k_34
k_45
k_65
+
k_16
k_25
k_32
k_45
k_65
+
k_12
k_25
k_32
k_45
k_65
+
k_16
k_21
k_32
k_45
k_65
+
k_16
k_25
k_32
k_43
k_65
+
k_12
k_25
k_32
k_43
k_65
+
k_16
k_21
k_32
k_43
k_65
+
k_12
k_25
k_34
k_45
k_61
+
k_12
k_23
k_34
k_45
k_61
+
k_12
k_25
k_32
k_45
k_61
+
k_12
k_25
k_32
k_43
k_61
C6_sum
=
k_16
k_25
k_34
k_45
k_56
+
k_12
k_25
k_34
k_45
k_56
+
k_16
k_23
k_34
k_45
k_56
+
k_12
k_23
k_34
k_45
k_56
+
k_16
k_21
k_34
k_45
k_56
+
k_16
k_25
k_32
k_45
k_56
+
k_12
k_25
k_32
k_45
k_56
+
k_16
k_21
k_32
k_45
k_56
+
k_16
k_25
k_32
k_43
k_56
+
k_12
k_25
k_32
k_43
k_56
+
k_16
k_21
k_32
k_43
k_56
+
k_16
k_21
k_32
k_43
k_54
+
k_16
k_21
k_34
k_45
k_52
+
k_16
k_21
k_32
k_45
k_52
+
k_16
k_21
k_32
k_43
k_52
C_sum
=
C1_sum
+
C2_sum
+
C3_sum
+
C4_sum
+
C5_sum
+
C6_sum
C1
=
C_T
C1_sum
C_sum
C2
=
C_T
C2_sum
C_sum
C3
=
C_T
C3_sum
C_sum
C4
=
C_T
C4_sum
C_sum
C5
=
C_T
C5_sum
C_sum
C6
=
C_T
C6_sum
C_sum
Component: NBC_current
I_NaGl_pSS
=
-
F
n
z_Na
alpha_p
k_12
C_1
-
k_21
C_2
+
z_c
delta
k_16
C_1
-
k_61
C_6
+
n
z_Na
alpha_pp
k_56
C_5
-
k_65
C_6
I_NaGl_SS
=
-
F
z_c
k_16
C1
-
k_61
C6
+
z_c
+
z_Na
n
k_25
C2
-
k_52
C5
+
z_c
+
z_Na
n
k_34
C3
-
k_43
C4
J_Na
=
k_25
C2
-
k_52
C5
+
k_34
C3
-
k_43
C4
Component: phenomonological_constants
lambda
=
ks_12
k0_23
k_43
k_54
k_65
+
ks_12
k0_23
k_34
k_54
k_65
+
ks_12
k0_23
k_45
k_52
k_65
+
ks_12
k0_23
k_43
k_52
k_65
+
ks_12
k0_23
k_34
k_52
k_65
+
ks_12
k0_23
k_34
k_45
k_65
+
ks_12
k0_23
k_45
k_56
k_61
+
ks_12
k0_23
k_43
k_56
k_61
+
ks_12
k0_23
k_34
k_56
k_61
+
ks_12
k0_23
k_43
k_54
k_61
+
ks_12
k0_23
k_34
k_54
k_61
+
ks_12
k0_23
k_45
k_52
k_61
+
ks_12
k0_23
k_43
k_52
k_61
+
ks_12
k0_23
k_34
k_52
k_61
+
ks_12
k0_23
k_34
k_45
k_61
+
ks_12
k0_23
k_34
k_45
k_56
chi
=
1
lambda
ks_12
k_32
k_43
k_54
k_65
+
ks_12
k_25
k_43
k_54
k_65
+
ks_12
k_25
k_34
k_54
k_65
+
ks_12
k_25
k_32
k_54
k_65
+
ks_12
k_34
k_45
k_52
k_65
+
ks_12
k_32
k_45
k_52
k_65
+
ks_12
k_32
k_43
k_52
k_65
+
ks_12
k_25
k_34
k_45
k_65
+
ks_12
k_25
k_32
k_45
k_65
+
ks_12
k_25
k_32
k_43
k_65
+
ks_12
k_34
k_45
k_56
k_61
+
ks_12
k_32
k_45
k_56
k_61
+
ks_12
k_32
k_43
k_56
k_61
+
ks_12
k_32
k_43
k_54
k_61
+
ks_12
k_25
k_43
k_54
k_61
+
ks_12
k_25
k_34
k_54
k_61
+
ks_12
k_25
k_32
k_54
k_61
+
ks_12
k_34
k_45
k_52
k_61
+
ks_12
k_32
k_45
k_52
k_61
+
ks_12
k_32
k_43
k_52
k_61
+
ks_12
k_25
k_34
k_45
k_61
+
ks_12
k_25
k_32
k_45
k_61
+
ks_12
k_25
k_32
k_43
k_61
+
ks_12
k_25
k_34
k_45
k_56
+
ks_12
k_25
k_32
k_45
k_56
+
ks_12
k_25
k_32
k_43
k_56
beta
=
1
lambda
k0_23
k_16
k_43
k_54
k_65
+
k0_23
k_16
k_34
k_54
k_65
+
k0_23
k_16
k_45
k_52
k_65
+
k0_23
k_16
k_43
k_52
k_65
+
k0_23
k_16
k_34
k_52
k_65
+
k0_23
k_16
k_34
k_45
k_65
+
k0_23
k_34
k_45
k_56
k_61
+
k0_23
k_16
k_34
k_45
k_56
alpha
=
1
lambda
k_21
k_32
k_43
k_54
k_65
+
k_16
k_32
k_43
k_54
k_65
+
k_16
k_25
k_43
k_54
k_65
+
k_16
k_21
k_43
k_54
k_65
+
k_16
k_25
k_34
k_54
k_65
+
k_16
k_21
k_34
k_54
k_65
+
k_16
k_25
k_32
k_54
k_65
+
k_16
k_21
k_32
k_54
k_65
+
k_21
k_34
k_45
k_52
k_65
+
k_16
k_34
k_45
k_52
k_65
+
k_21
k_32
k_45
k_52
k_65
+
k_16
k_32
k_45
k_52
k_65
+
k_21
k_32
k_43
k_52
k_65
+
k_16
k_32
k_43
k_52
k_65
+
k_16
k_25
k_34
k_45
k_65
+
k_16
k_21
k_34
k_45
k_65
+
k_16
k_25
k_32
k_45
k_65
+
k_16
k_21
k_32
k_45
k_65
+
k_16
k_25
k_32
k_43
k_65
+
k_16
k_21
k_32
k_43
k_65
+
k_25
k_34
k_45
k_56
k_61
+
k_21
k_34
k_45
k_56
k_61
+
k_25
k_32
k_45
k_56
k_61
+
k_21
k_32
k_45
k_56
k_61
+
k_25
k_32
k_43
k_56
k_61
+
k_21
k_32
k_43
k_56
k_61
+
k_21
k_32
k_43
k_54
k_61
+
k_21
k_34
k_45
k_52
k_61
+
k_21
k_32
k_45
k_52
k_61
+
k_21
k_32
k_43
k_52
k_61
+
k_16
k_25
k_34
k_45
k_56
+
k_16
k_21
k_34
k_45
k_56
+
k_16
k_25
k_32
k_45
k_56
+
k_16
k_21
k_32
k_45
k_56
+
k_16
k_25
k_32
k_43
k_56
+
k_16
k_21
k_32
k_43
k_56
+
k_16
k_21
k_32
k_43
k_54
+
k_16
k_21
k_34
k_45
k_52
+
k_16
k_21
k_32
k_45
k_52
+
k_16
k_21
k_32
k_43
k_52
gamma
=
1
lambda
k_16
k_21
k_32
k_43
k_54
k_65
+
k_16
k_21
k_34
k_45
k_52
k_65
+
k_16
k_21
k_32
k_45
k_52
k_65
+
k_16
k_21
k_32
k_43
k_52
k_65
phi
=
1
lambda
-
ks_12
k_25
k_34
k_45
k_56
k_61
-
ks_12
k_25
k_32
k_45
k_56
k_61
-
ks_12
k_25
k_32
k_43
k_56
k_61
epsilon
=
1
lambda
-
ks_12
k0_23
k_34
k_45
k_56
k_61
Imax_gluc
=
2
F
C_T
epsilon
Na_o
beta
+
Na_o
Imax_Na
=
2
F
C_T
phi
+
epsilon
glucose_o
chi
+
glucose_o
Khalf_gluc
=
alpha
+
chi
Na_o
beta
+
Na_o
Khalf_Na
=
alpha
+
beta
glucose_o
chi
+
glucose_o
Source
Derived from workspace
Mackenzie, Loo, Panayotova-Heiermann and Wright, 1996
at changeset
b0a32e5099ae
.
Collaboration
To begin collaborating on this work, please use your git client and issue this command:
Downloads
Download This File
Complete Archive as .tgz
COMBINE Archive (exposure)
Views Available
Documentation
Model Metadata
Mathematics
Generated Code
Cite this model
Source View
Semantic Metadata
Launch with OpenCOR
Tools
CombineArchive Web
Compare...
Export Exposure Metadata
Report a problem with this resource
License
The terms of use/license for this work is unspecified.
Navigation
Renal SGLT2 model