Location: Wang, Sobie, 2008 @ e46c3504eb74 / wang_sobie_2008.cellml

Author:
Dougal Cowan <devnull@localhost>
Date:
2011-11-28 11:08:58+13:00
Desc:
Fixed calcium concentration equation (i_CaT to i_NaCa) as reported by Kamran Bigdely-Shamloo.
Permanent Source URI:
https://models.physiomeproject.org/workspace/wang_sobie_2008/rawfile/e46c3504eb74c2eac4ceab5d57a78c97b7110568/wang_sobie_2008.cellml

<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="wang_model_2008" name="wang_model_2008">
<documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <articleinfo>
        <title>Mathematical model of the neonatal mouse ventricular action potential</title>
        <author>
          <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
          <affiliation>
            <shortaffil>ABI</shortaffil>
          </affiliation>
        </author>
      </articleinfo>
      <section id="sec_status">
        <title>Model Status</title>
        <para>
            This CellML model is known to run in OpenCell and COR to recreate the published results.  The units have been checked and are consistent.
          </para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>
ABSTRACT: Therapies for heart disease are based largely on our understanding of the adult myocardium. The dramatic differences in action potential (AP) shape between neonatal and adult cardiac myocytes, however, indicate that a different set of molecular interactions in neonatal myocytes necessitates different treatment for newborns. Computational modeling is useful for synthesizing data to determine how interactions between components lead to systems-level behavior, but this technique has not been used extensively to study neonatal heart cell function. We created a mathematical model of the neonatal (day 1) mouse myocyte by modifying, on the basis of experimental data, the densities and/or formulations of ion transport mechanisms in an adult cell model. The new model reproduces the characteristic AP shape of neonatal cells, with a brief plateau phase and longer duration than the adult (action potential duration at 80% repolarization = 60.1 vs. 12.6 ms). The simulation results are consistent with experimental data, including 1) decreased density and altered inactivation of transient outward K+ currents, 2) increased delayed rectifier K+ currents, 3) Ca2+ entry through T-type as well as L-type Ca2+ channels, 4) increased Ca2+ influx through Na+/Ca2+ exchange, and 5) Ca2+ transients resulting from transmembrane Ca2+ entry rather than release from the sarcoplasmic reticulum (SR). Simulations performed with the model generated novel predictions, including increased SR Ca2+ leak and elevated intracellular Na+ concentration in neonatal compared with adult myocytes. This new model can therefore be used for testing hypotheses and obtaining a better quantitative understanding of differences between neonatal and adult physiology.
</para>
        
        <para>
The original paper reference is cited below:
</para>
        <para>
          Mathematical model of the neonatal mouse ventricular action potential, Linda J. Wang and Eric A. Sobie, 2008,<emphasis>American Journal of Physiology: Heart and Circulatory Physiology</emphasis>, 294, H2565-H2575. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;amp;db=PubMed&amp;amp;list_uids=18408122&amp;amp;dopt=Abstract">PubMed ID: 18408122</ulink>
        </para>
		
		       <informalfigure float="0" id="fig_cell_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>cell diagram</title>
              </objectinfo>
              <imagedata fileref="wang_2008.png"/>
            </imageobject>
          </mediaobject>
          <caption>Schematic diagram of the neonatal mouse model.</caption>
        </informalfigure> 		
      </sect1>
    </article>
  </documentation>
   
   
   
   
   
   <units name="millisecond">
      <unit prefix="milli" units="second"/>
   </units>
   <units name="per_millisecond">
      <unit exponent="-1" prefix="milli" units="second"/>
   </units>
   <units name="micromolar_per_millisecond">
      <unit units="micromolar"/>
      <unit exponent="-1" units="millisecond"/>
   </units>
   <units name="per_micromolar_millisecond">
      <unit exponent="-1" units="micromolar"/>
      <unit exponent="-1" units="millisecond"/>
   </units>
   <units name="micromolar3_per_millisecond">
      <unit exponent="-3" units="micromolar"/>
      <unit exponent="-1" units="millisecond"/>
   </units>
   <units name="micromolar4_per_millisecond">
      <unit exponent="-4" units="micromolar"/>
      <unit exponent="-1" units="millisecond"/>
   </units>
   <units name="millivolt">
      <unit prefix="milli" units="volt"/>
   </units>
   <units name="per_millivolt">
      <unit exponent="-1" prefix="milli" units="volt"/>
   </units>
   <units name="millivolt2">
      <unit exponent="2" prefix="milli" units="volt"/>
   </units>
   <units name="per_millivolt_millisecond">
      <unit exponent="-1" units="millivolt"/>
      <unit exponent="-1" units="millisecond"/>
   </units>
   <units name="milliS_per_microF">
      <unit prefix="milli" units="siemens"/>
      <unit exponent="-1" prefix="micro" units="farad"/>
   </units>
   <units name="picoF">
      <unit prefix="pico" units="farad"/>
   </units>
   <units name="per_picoF">
      <unit exponent="-1" units="picoF"/>
   </units>
   <units name="microF_per_cm2">
      <unit prefix="micro" units="farad"/>
      <unit exponent="-2" prefix="centi" units="metre"/>
   </units>
   <units name="picoA_per_picoF">
      <unit prefix="pico" units="ampere"/>
      <unit exponent="-1" prefix="pico" units="farad"/>
   </units>
   <units name="micromolar">
      <unit prefix="micro" units="mole"/>
      <unit exponent="-1" units="litre"/>
   </units>
   <units name="joule_per_mole_kelvin">
      <unit units="joule"/>
      <unit exponent="-1" units="mole"/>
      <unit exponent="-1" units="kelvin"/>
   </units>
   <units name="coulomb_per_millimole">
      <unit units="coulomb"/>
      <unit exponent="-1" prefix="milli" units="mole"/>
   </units>
   <units name="cm2">
      <unit exponent="2" prefix="centi" units="metre"/>
   </units>
   <units name="cm2_per_microF">
      <unit exponent="2" prefix="centi" units="metre"/>
	  <unit exponent="-1" prefix="micro" units="farad"/>
   </units>
   <units name="cm_per_second">
      <unit prefix="centi" units="metre"/>
	  <unit exponent="-1" units="second"/>
   </units>
   <units name="microlitre">
      <unit prefix="micro" units="litre"/>
   </units>
   
   <component name="environment">
      <variable cmeta:id="environment_time" name="time" public_interface="out" units="millisecond"/>
   </component>
   
   <component name="membrane">
      <variable initial_value="-80.6475" name="V" public_interface="out" units="millivolt"/>
      <variable initial_value="1" name="Cm" public_interface="out" units="microF_per_cm2"/>
      <variable initial_value="2.2826e-6" name="Vmyo" public_interface="out" units="microlitre"/>
      <variable initial_value="0.12e-8" name="VJSR" public_interface="out" units="microlitre"/>
      <variable initial_value="2.098e-7" name="VNSR" public_interface="out" units="microlitre"/>
      <variable initial_value="3.0734e-8" name="Vss" public_interface="out" units="microlitre"/>
      <variable initial_value="1.5410e-5" name="Acap" public_interface="out" units="cm2"/>
      <variable initial_value="5400" name="Ko" public_interface="out" units="micromolar"/>
      <variable initial_value="140000" name="Nao" public_interface="out" units="micromolar"/>
      <variable initial_value="1000" name="Cao" public_interface="out" units="micromolar"/>
	  <variable initial_value="132000" name="Clo" public_interface="out" units="micromolar"/>
      <variable initial_value="30000" name="Cli" public_interface="out" units="micromolar"/>
      <variable initial_value="8.314" name="R" public_interface="out" units="joule_per_mole_kelvin"/>
      <variable initial_value="298" name="T" public_interface="out" units="kelvin"/>
      <variable initial_value="96.5" name="F" public_interface="out" units="coulomb_per_millimole"/>
      
	  <variable name="i_stim" units="picoA_per_picoF"/>
	  <variable initial_value="20" name="stim_start" units="millisecond"/>
      <variable initial_value="500000" name="stim_end" units="millisecond"/>
      <variable initial_value="2000.0" name="stim_period" units="millisecond"/>
      <variable initial_value="0.5" name="stim_duration" units="millisecond"/>
      <variable initial_value="-80" name="stim_amplitude" units="picoA_per_picoF"/>
      
	  <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="i_CaL" public_interface="in" units="picoA_per_picoF"/>
	  <variable name="i_CaT" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_pCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Cab" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Na" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Nab" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kto_f" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_K1" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Ks" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kur" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kss" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_ClCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kr" public_interface="in" units="picoA_per_picoF"/>
      
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_stim</ci>
            <piecewise>
               <piece>
                  <ci>stim_amplitude</ci>
                  <apply>
                     <and/>
                     <apply>
                        <geq/>
                        <ci>time</ci>
                        <ci>stim_start</ci>
                     </apply>
                     <apply>
                        <leq/>
                        <ci>time</ci>
                        <ci>stim_end</ci>
                     </apply>
                     <apply>
                        <leq/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>time</ci>
                              <ci>stim_start</ci>
                           </apply>
                           <apply>
                              <times/>
                              <apply>
                                 <floor/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <minus/>
                                       <ci>time</ci>
                                       <ci>stim_start</ci>
                                    </apply>
                                    <ci>stim_period</ci>
                                 </apply>
                              </apply>
                              <ci>stim_period</ci>
                           </apply>
                        </apply>
                        <ci>stim_duration</ci>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picoA_per_picoF">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>V</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>i_CaL</ci>
				  <ci>i_CaT</ci>
                  <ci>i_pCa</ci>
                  <ci>i_NaCa</ci>
                  <ci>i_Cab</ci>
                  <ci>i_Na</ci>
                  <ci>i_Nab</ci>
                  <ci>i_NaK</ci>
                  <ci>i_Kto_f</ci>
                  <ci>i_K1</ci>
                  <ci>i_Ks</ci>
                  <ci>i_Kur</ci>
                  <ci>i_Kss</ci>
                  <ci>i_Kr</ci>
                  <ci>i_ClCa</ci>
                  <ci>i_stim</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="calcium_concentration">
      <variable initial_value="0.2049" name="Cai" public_interface="out" units="micromolar"/>
      <variable initial_value="0.1867" name="Cass" public_interface="out" units="micromolar"/>
      <variable initial_value="705.5417" name="CaJSR" public_interface="out" units="micromolar"/>
      <variable initial_value="703.3063" name="CaNSR" public_interface="out" units="micromolar"/>
      
	  <variable name="Bi" units="dimensionless"/>
      <variable name="Bss" units="dimensionless"/>
      <variable name="BJSR" units="dimensionless"/>
      <variable cmeta:id="calcium_concentration_CMDN_tot" initial_value="25" name="CMDN_tot" units="micromolar"/>
      <variable cmeta:id="calcium_concentration_CSQN_tot" initial_value="15000" name="CSQN_tot" units="micromolar"/>
      <variable initial_value="0.238" name="Km_CMDN" units="micromolar"/>
      <variable initial_value="800" name="Km_CSQN" units="micromolar"/>
      
	  <variable name="Acap" public_interface="in" units="cm2"/>
      <variable name="Vmyo" public_interface="in" units="microlitre"/>
      <variable name="VJSR" public_interface="in" units="microlitre"/>
      <variable name="Vss" public_interface="in" units="microlitre"/>
      <variable name="VNSR" public_interface="in" units="microlitre"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="i_Cab" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_CaL" public_interface="in" units="picoA_per_picoF"/>
	  <variable name="i_CaT" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_pCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="J_leak" public_interface="in" units="micromolar_per_millisecond"/>
      <variable name="J_rel" public_interface="in" units="micromolar_per_millisecond"/>
      <variable name="J_up" public_interface="in" units="micromolar_per_millisecond"/>
      <variable name="J_tr" public_interface="in" units="micromolar_per_millisecond"/>
      <variable name="J_trpn" public_interface="in" units="micromolar_per_millisecond"/>
      <variable name="J_xfer" public_interface="in" units="micromolar_per_millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><apply><diff/><bvar><ci>time</ci></bvar><ci>Cai</ci></apply><apply><times/><ci>Bi</ci><apply><minus/><apply><plus/><ci>J_leak</ci><ci>J_xfer</ci></apply><apply><plus/><ci>J_up</ci><ci>J_trpn</ci></apply></apply></apply></apply><apply><eq/><apply><diff/><bvar><ci>time</ci></bvar><ci>Cass</ci></apply><apply><times/><ci>Bss</ci><apply><minus/><apply><divide/><apply><times/><ci>J_rel</ci><ci>VJSR</ci></apply><ci>Vss</ci></apply><apply><plus/><apply><divide/><apply><times/><ci>J_xfer</ci><ci>Vmyo</ci></apply><ci>Vss</ci></apply><apply><times/><apply><minus/><apply><plus/><ci>i_CaL</ci><ci>i_Cab</ci><ci>i_pCa</ci><ci>i_CaT</ci></apply><apply><times/><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn><ci>i_NaCa</ci></apply></apply><apply><divide/><apply><times/><ci>Acap</ci><ci>Cm</ci></apply><apply><times/><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn><ci>Vss</ci><ci>F</ci></apply></apply></apply></apply></apply></apply></apply><apply><eq/><apply><diff/><bvar><ci>time</ci></bvar><ci>CaJSR</ci></apply><apply><times/><ci>BJSR</ci><apply><minus/><ci>J_xfer</ci><ci>J_rel</ci></apply></apply></apply><apply><eq/><apply><diff/><bvar><ci>time</ci></bvar><ci>CaNSR</ci></apply><apply><minus/><apply><divide/><apply><times/><apply><minus/><ci>J_up</ci><ci>J_leak</ci></apply><ci>Vmyo</ci></apply><ci>VNSR</ci></apply><apply><divide/><apply><times/><ci>J_tr</ci><ci>VJSR</ci></apply><ci>VNSR</ci></apply></apply></apply><apply><eq/><ci>Bi</ci><apply><power/><apply><plus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn><apply><divide/><apply><times/><ci>CMDN_tot</ci><ci>Km_CMDN</ci></apply><apply><power/><apply><plus/><ci>Km_CMDN</ci><ci>Cai</ci></apply><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn></apply></apply></apply><apply><minus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn></apply></apply></apply><apply><eq/><ci>Bss</ci><apply><power/><apply><plus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn><apply><divide/><apply><times/><ci>CMDN_tot</ci><ci>Km_CMDN</ci></apply><apply><power/><apply><plus/><ci>Km_CMDN</ci><ci>Cass</ci></apply><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn></apply></apply></apply><apply><minus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn></apply></apply></apply><apply><eq/><ci>BJSR</ci><apply><power/><apply><plus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn><apply><divide/><apply><times/><ci>CSQN_tot</ci><ci>Km_CSQN</ci></apply><apply><power/><apply><plus/><ci>Km_CSQN</ci><ci>CaJSR</ci></apply><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn></apply></apply></apply><apply><minus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn></apply></apply></apply></math>
   </component>
   
   <component name="calcium_fluxes">
      <variable cmeta:id="calcium_fluxes_J_leak" name="J_leak" public_interface="out" units="micromolar_per_millisecond"/>
      <variable cmeta:id="calcium_fluxes_J_rel" name="J_rel" public_interface="out" units="micromolar_per_millisecond"/>
      <variable cmeta:id="calcium_fluxes_J_up" name="J_up" public_interface="out" units="micromolar_per_millisecond"/>
      <variable cmeta:id="calcium_fluxes_J_tr" name="J_tr" public_interface="out" units="micromolar_per_millisecond"/>
      <variable name="J_trpn" public_interface="out" units="micromolar_per_millisecond"/>
      <variable name="J_xfer" public_interface="out" units="micromolar_per_millisecond"/>
      <variable initial_value="0.00237" name="k_plus_htrpn" public_interface="out" units="per_micromolar_millisecond"/>
      <variable initial_value="3.2e-5" name="k_minus_htrpn" public_interface="out" units="per_millisecond"/>
      <variable initial_value="0.0327" name="k_plus_ltrpn" public_interface="out" units="per_micromolar_millisecond"/>
      <variable initial_value="0.0196" name="k_minus_ltrpn" public_interface="out" units="per_millisecond"/>
      
	  <variable initial_value="2.8603e-14" name="P_RyR" units="dimensionless"/>
      <variable initial_value="0.45" name="v1" units="per_millisecond"/>
      <variable initial_value="20" name="tau_tr" units="millisecond"/>
      <variable initial_value="2.088e-5" name="v2" units="per_millisecond"/>
      <variable initial_value="8" name="tau_xfer" units="millisecond"/>
      <variable initial_value="0.09" name="v3" units="micromolar_per_millisecond"/>
      <variable initial_value="0.5" name="Km_up" units="micromolar"/>
      
	  <variable name="LTRPN_tot" public_interface="in" units="micromolar"/>
      <variable name="HTRPN_tot" public_interface="in" units="micromolar"/>
      <variable name="LTRPN_Ca" public_interface="in" units="micromolar"/>
      <variable name="HTRPN_Ca" public_interface="in" units="micromolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="i_CaL_max" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_CaL" public_interface="in" units="picoA_per_picoF"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <variable name="Cass" public_interface="in" units="micromolar"/>
      <variable name="CaJSR" public_interface="in" units="micromolar"/>
      <variable name="CaNSR" public_interface="in" units="micromolar"/>
      <variable name="P_O1" public_interface="in" units="dimensionless"/>
      <variable name="P_O2" public_interface="in" units="dimensionless"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>J_rel</ci>
            <apply>
               <times/>
               <ci>v1</ci>
               <apply>
                  <plus/>
                  <ci>P_O1</ci>
                  <ci>P_O2</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>CaJSR</ci>
                  <ci>Cass</ci>
               </apply>
               <ci>P_RyR</ci>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>J_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>CaNSR</ci>
                  <ci>CaJSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>J_xfer</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Cass</ci>
                  <ci>Cai</ci>
               </apply>
               <ci>tau_xfer</ci>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>J_leak</ci>
            <apply>
               <times/>
               <ci>v2</ci>
               <apply>
                  <minus/>
                  <ci>CaNSR</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
        
		 <apply>
            <eq/>
            <ci>J_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>v3</ci>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>Km_up</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
        
  		 <apply>
            <eq/>
            <ci>J_trpn</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>k_plus_htrpn</ci>
                     <ci>Cai</ci>
                     <apply>
                        <minus/>
                        <ci>HTRPN_tot</ci>
                        <ci>HTRPN_Ca</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_plus_ltrpn</ci>
                     <ci>Cai</ci>
                     <apply>
                        <minus/>
                        <ci>LTRPN_tot</ci>
                        <ci>LTRPN_Ca</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>k_minus_htrpn</ci>
                     <ci>HTRPN_Ca</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_minus_ltrpn</ci>
                     <ci>LTRPN_Ca</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_RyR</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.04</cn>
                  </apply>
                  <ci>P_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.1</cn>
                        <ci>i_CaL</ci>
                     </apply>
                     <ci>i_CaL_max</ci>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">648</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="calcium_buffering">
      <variable cmeta:id="calcium_buffering_LTRPN_tot" initial_value="35" name="LTRPN_tot" public_interface="out" units="micromolar"/>
      <variable initial_value="70" name="HTRPN_tot" public_interface="out" units="micromolar"/>
      <variable initial_value="8.9220" name="LTRPN_Ca" public_interface="out" units="micromolar"/>
      <variable initial_value="66.0407" name="HTRPN_Ca" public_interface="out" units="micromolar"/>
      
	  <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <variable name="k_plus_htrpn" public_interface="in" units="per_micromolar_millisecond"/>
      <variable name="k_minus_htrpn" public_interface="in" units="per_millisecond"/>
      <variable name="k_plus_ltrpn" public_interface="in" units="per_micromolar_millisecond"/>
      <variable name="k_minus_ltrpn" public_interface="in" units="per_millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>LTRPN_Ca</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_plus_ltrpn</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>LTRPN_tot</ci>
                     <ci>LTRPN_Ca</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k_minus_ltrpn</ci>
                  <ci>LTRPN_Ca</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>HTRPN_Ca</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_plus_htrpn</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>HTRPN_tot</ci>
                     <ci>HTRPN_Ca</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k_minus_htrpn</ci>
                  <ci>HTRPN_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="ryanodine_receptors">
      <variable initial_value="1.1e-3" name="P_O1" public_interface="out" units="dimensionless"/>
      <variable initial_value="2.9799e-8" name="P_O2" public_interface="out" units="dimensionless"/>
      <variable name="P_C1" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.1003" name="P_C2" public_interface="out" units="dimensionless"/>
      
	  <variable initial_value="0.00608" name="k_plus_a" units="micromolar4_per_millisecond"/>
      <variable initial_value="0.07125" name="k_minus_a" units="per_millisecond"/>
      <variable initial_value="0.00405" name="k_plus_b" units="micromolar3_per_millisecond"/>
      <variable initial_value="0.965" name="k_minus_b" units="per_millisecond"/>
      <variable initial_value="0.009" name="k_plus_c" units="per_millisecond"/>
      <variable initial_value="0.0008" name="k_minus_c" units="per_millisecond"/>
      <variable initial_value="3" name="m" units="dimensionless"/>
      <variable initial_value="4" name="n" units="dimensionless"/>
      
	  <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Cass" public_interface="in" units="micromolar"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_O1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>k_plus_a</ci>
                     <apply>
                        <power/>
                        <ci>Cass</ci>
                        <ci>n</ci>
                     </apply>
                     <ci>P_C1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_minus_b</ci>
                     <ci>P_O2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_minus_c</ci>
                     <ci>P_C2</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>k_minus_a</ci>
                     <ci>P_O1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_plus_b</ci>
                     <apply>
                        <power/>
                        <ci>Cass</ci>
                        <ci>m</ci>
                     </apply>
                     <ci>P_O1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_plus_c</ci>
                     <ci>P_O1</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>P_C1</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>P_C2</ci>
                  <ci>P_O1</ci>
                  <ci>P_O2</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_O2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_plus_b</ci>
                  <apply>
                     <power/>
                     <ci>Cass</ci>
                     <ci>m</ci>
                  </apply>
                  <ci>P_O1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_minus_b</ci>
                  <ci>P_O2</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_C2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_plus_c</ci>
                  <ci>P_O1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_minus_c</ci>
                  <ci>P_C2</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="L_type_calcium_current">
      <variable cmeta:id="L_type_calcium_current_i_CaL" name="i_CaL" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="7" name="i_CaL_max" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="63" name="E_CaL" public_interface="out" units="millivolt"/>
      
	  <variable initial_value="0.19019" name="g_CaL" units="milliS_per_microF"/>
      <variable initial_value="4.4776e-12" name="O" units="dimensionless"/>
      <variable name="C1" units="dimensionless"/>
      <variable initial_value="1.6996e-4" name="C2" units="dimensionless"/>
      <variable initial_value="1.1754e-8" name="C3" units="dimensionless"/>
      <variable initial_value="6.1239e-10" name="C4" units="dimensionless"/>
      <variable initial_value="1.5450e-9" name="I1" units="dimensionless"/>
      <variable initial_value="6.4226e-8" name="I2" units="dimensionless"/>
      <variable initial_value="6.5201e-7" name="I3" units="dimensionless"/>
      <variable name="alpha" units="per_millisecond"/>
      <variable name="beta" units="per_millisecond"/>
      <variable name="gamma" units="per_millisecond"/>
      <variable name="Kpcf" units="per_millisecond"/>
      <variable initial_value="0.0005" name="Kpcb" units="per_millisecond"/>
      <variable initial_value="0.23324" name="Kpc_max" units="per_millisecond"/>
      <variable initial_value="20" name="Kpc_half" units="micromolar"/>
      
	  <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Cass" public_interface="in" units="micromolar"/>
     
 	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_CaL</ci>
            <apply>
               <times/>
               <ci>g_CaL</ci>
               <ci>O</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_CaL</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha</ci>
                     <ci>C4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpcb</ci>
                     <ci>I1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>I2</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>O</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>beta</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <ci>O</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
        
		 <apply>
            <eq/>
            <ci>C1</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>O</ci>
                  <ci>C2</ci>
                  <ci>C2</ci>
                  <ci>C3</ci>
                  <ci>C4</ci>
                  <ci>I1</ci>
                  <ci>I2</ci>
                  <ci>I3</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>alpha</ci>
                     <ci>C1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>beta</ci>
                     <ci>C3</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta</ci>
                     <ci>C2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>alpha</ci>
                     <ci>C2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>alpha</ci>
                     <ci>C2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>beta</ci>
                     <ci>C4</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>beta</ci>
                     <ci>C3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>alpha</ci>
                     <ci>C3</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C4</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>alpha</ci>
                     <ci>C3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>beta</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.01</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>Kpcb</ci>
                           <ci>beta</ci>
                           <ci>I1</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>gamma</ci>
                           <ci>C4</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.002</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>beta</ci>
                           <ci>I2</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>C4</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">4</cn>
                     <ci>beta</ci>
                     <ci>Kpcb</ci>
                     <ci>I3</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>beta</ci>
                     <ci>C4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha</ci>
                     <ci>C4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                     <ci>gamma</ci>
                     <ci>Kpcf</ci>
                     <ci>C4</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>I3</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>I1</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.01</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>gamma</ci>
                           <ci>C4</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>beta</ci>
                           <ci>Kpcf</ci>
                           <ci>I1</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>Kpcb</ci>
                  <ci>I1</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>O</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>I2</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpcb</ci>
                     <ci>I3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.002</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>C4</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>beta</ci>
                           <ci>I2</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>gamma</ci>
                  <ci>I2</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>I1</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>I3</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <ci>I2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                     <ci>gamma</ci>
                     <ci>Kpcf</ci>
                     <ci>C4</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">4</cn>
                     <ci>beta</ci>
                     <ci>Kpcb</ci>
                     <ci>I3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpcb</ci>
                     <ci>I3</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>alpha</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.4</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.7</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <power/>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                                       </apply>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">10</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.75</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <power/>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">400</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>beta</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.05</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>gamma</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Kpc_max</ci>
                  <ci>Cass</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Kpc_half</ci>
                  <ci>Cass</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>Kpcf</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">13</cn>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.5</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">100</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="T_type_calcium_current">
      <variable cmeta:id="T_type_calcium_current_i_CaT" name="i_CaT" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="50" name="E_CaT" units="millivolt"/>
      <variable initial_value="0.055" name="g_CaT" units="milliS_per_microF"/>
      
	  <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="b" private_interface="in" units="dimensionless"/>
      <variable name="g" private_interface="in" units="dimensionless"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_CaT</ci>
            <apply>
               <times/>
               <ci>g_CaT</ci>
               <ci>b</ci>
               <ci>g</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_CaT</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="T_type_calcium_current_b_gate">
      <variable initial_value="0.0047" name="b" public_interface="out" units="dimensionless"/>
      <variable name="b_infinity" units="dimensionless"/>
      <variable name="tau_b" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>b_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
						<apply>
                           <minus/>
						   <apply>
                              <plus/>
					          <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">48</cn>
                           </apply>
						</apply>
						<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
		 
		 <apply>
            <eq/>
            <ci>tau_b</ci>
            <apply>
               <plus/>
			   <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.1</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">5.4</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
						   <apply>
                              <plus/>
					          <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
                           </apply>
						   <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
        
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>b</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>b_infinity</ci>
				  <ci>b</ci>
               </apply>
               <ci>tau_b</ci>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="T_type_calcium_current_g_gate">
      <variable initial_value="0.9020" name="g" public_interface="out" units="dimensionless"/>
      <variable name="g_infinity" units="dimensionless"/>
      <variable name="tau_g" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
						<apply>
                           <plus/>
					       <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">66</cn>
                        </apply>
						<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.6</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
		 
		 <apply>
            <eq/>
            <ci>tau_g</ci>
            <apply>
               <plus/>
			   <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">8</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">32</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
						   <apply>
                              <plus/>
					          <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65</cn>
                           </apply>
						   <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
        
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>g</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>g_infinity</ci>
				  <ci>g</ci>
               </apply>
               <ci>tau_g</ci>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="calcium_pump_current">
      <variable cmeta:id="calcium_pump_current_i_pCa" name="i_pCa" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="0.2" name="i_pCa_max" units="picoA_per_picoF"/>
      <variable initial_value="0.5" name="Km_pCa" units="micromolar"/>
      
	  <variable name="Cai" public_interface="in" units="micromolar"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_pCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_pCa_max</ci>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>Km_pCa</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
  
   <component name="sodium_calcium_exchange_current">
      <variable cmeta:id="sodium_calcium_exchange_current_i_NaCa" name="i_NaCa" public_interface="out" units="picoA_per_picoF"/>
     
   	  <variable initial_value="907.68" name="k_NaCa" units="picoA_per_picoF"/>
      <variable initial_value="87500" name="K_mNa" units="micromolar"/>
      <variable initial_value="1380" name="K_mCa" units="micromolar"/>
      <variable initial_value="0.1" name="k_sat" units="dimensionless"/>
      <variable initial_value="0.35" name="eta" units="dimensionless"/>
      
	  <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Nai" public_interface="in" units="micromolar"/>
      <variable name="Nao" public_interface="in" units="micromolar"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <variable name="Cao" public_interface="in" units="micromolar"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>k_NaCa</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <power/>
                                    <ci>K_mNa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                                 <apply>
                                    <power/>
                                    <ci>Nao</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>K_mCa</ci>
                           <ci>Cao</ci>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <ci>k_sat</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>eta</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>eta</ci>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Nai</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>Cao</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>eta</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="calcium_background_current">
      <variable cmeta:id="calcium_background_current_i_Cab" name="i_Cab" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="0.00025" name="g_Cab" units="milliS_per_microF"/>
      <variable name="E_CaN" units="millivolt"/>
      
	  <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <variable name="Cao" public_interface="in" units="micromolar"/>
	  
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Cab</ci>
            <apply>
               <times/>
               <ci>g_Cab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_CaN</ci>
               </apply>
            </apply>
         </apply>
		 
		 <apply>
            <eq/>
            <ci>E_CaN</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="sodium_concentration">
      <variable initial_value="2.1747e4" name="Nai" public_interface="out" units="micromolar"/>
      
	  <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Vmyo" public_interface="in" units="microlitre"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <variable name="Acap" public_interface="in" units="cm2"/>
      <variable name="i_Na" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Nab" public_interface="in" units="picoA_per_picoF"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Nai</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>i_Na</ci>
                        <ci>i_Nab</ci>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaCa</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Acap</ci>
                  <ci>Cm</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Vmyo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="fast_sodium_current">
      <variable cmeta:id="fast_sodium_current_i_Na" name="i_Na" public_interface="out" units="picoA_per_picoF"/>
      <variable name="E_Na" public_interface="out" units="millivolt"/>
      
	  <variable initial_value="10" name="g_Na" units="milliS_per_microF"/>
      
	  <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Nao" public_interface="in" units="micromolar"/>
      <variable name="Nai" public_interface="in" units="micromolar"/>
	  
	  <variable name="m" private_interface="in" units="dimensionless"/>
      <variable name="h" private_interface="in" units="dimensionless"/>
      <variable name="j" private_interface="in" units="dimensionless"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na</ci>
            <apply>
               <times/>
               <ci>g_Na</ci>
			   <apply>
                  <power/>
                  <ci>m</ci>
				  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
			   </apply>
			   <ci>h</ci>
			   <ci>j</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>E_Na</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Nao</ci>
                     <ci>Nai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="fast_sodium_current_m_gate">
      <variable initial_value="0.0032" name="m" public_interface="out" units="dimensionless"/>
      <variable name="alpha_m" units="per_millisecond"/>
      <variable name="beta_m" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.32</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
					 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
                  </apply>
               </apply>
			   <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
				  <apply>
                     <exp/>
					 <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">-0.1</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
					       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
                        </apply>
                     </apply>
				  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.08</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <minus/>
			   <ci>alpha_m</ci>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <ci>alpha_m</ci>
                     <ci>beta_m</ci>
                  </apply>
				  <ci>m</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="fast_sodium_current_h_gate">
      <variable initial_value="0.9606" name="h" public_interface="out" units="dimensionless"/>
      <variable name="alpha_h" units="per_millisecond"/>
      <variable name="beta_h" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.135</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         
		 <apply>
            <eq/>
            <ci>beta_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3.56</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.079</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">310000</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.35</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.13</cn>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.66</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.1</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <minus/>
			   <ci>alpha_h</ci>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <ci>alpha_h</ci>
                     <ci>beta_h</ci>
                  </apply>
				  <ci>h</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="fast_sodium_current_j_gate">
      <variable initial_value="0.9744" name="j" public_interface="out" units="dimensionless"/>
      <variable name="alpha_j" units="per_millisecond"/>
      <variable name="beta_j" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">127140</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2444</cn>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt_millisecond">3.474<sep/>-5</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04391</cn>
                                       </apply>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37.78</cn>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         
		 <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">2.535<sep/>-7</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <minus/>
			   <ci>alpha_j</ci>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <ci>alpha_j</ci>
                     <ci>beta_j</ci>
                  </apply>
				  <ci>j</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="sodium_background_current">
      <variable cmeta:id="sodium_background_current_i_Nab" name="i_Nab" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="0.0026" name="g_Nab" units="milliS_per_microF"/>
      
	  <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Nab</ci>
            <apply>
               <times/>
               <ci>g_Nab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="potassium_concentration">
      <variable initial_value="1.3645e5" name="Ki" public_interface="out" units="micromolar"/>
      
	  <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Vmyo" public_interface="in" units="microlitre"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <variable name="Acap" public_interface="in" units="cm2"/>
      <variable name="i_Kto_f" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_K1" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Ks" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kss" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kur" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kr" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ki</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>i_Kto_f</ci>
                           <ci>i_K1</ci>
                           <ci>i_Ks</ci>
                           <ci>i_Kss</ci>
                           <ci>i_Kur</ci>
                           <ci>i_Kr</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>i_NaK</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Acap</ci>
                  <ci>Cm</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Vmyo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="fast_transient_outward_potassium_current">
      <variable cmeta:id="fast_transient_outward_potassium_current_i_Kto_f" name="i_Kto_f" public_interface="out" units="picoA_per_picoF"/>
      <variable name="E_K" public_interface="out" units="millivolt"/>
      
	  <variable initial_value="0.1017" name="g_Kto_f" units="milliS_per_microF"/>
      <variable initial_value="0.0032" name="ato_f" units="dimensionless"/>
      <variable initial_value="0.7530" name="ito_f" units="dimensionless"/>
	  <variable name="ito_f_infinity" units="dimensionless"/>
	  <variable name="tau_ito_f" units="millisecond"/>
      <variable name="alpha_a" units="per_millisecond"/>
      <variable name="beta_a" units="per_millisecond"/>
      <variable name="alpha_i" units="per_millisecond"/>
      <variable name="beta_i" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Ki" public_interface="in" units="micromolar"/>
      <variable name="Ko" public_interface="in" units="micromolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kto_f</ci>
            <apply>
               <times/>
               <ci>g_Kto_f</ci>
               <apply>
                  <power/>
                  <ci>ato_f</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.5</cn>
               </apply>
               <ci>ito_f</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ato_f</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_a</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>ato_f</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_a</ci>
                  <ci>ato_f</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ito_f</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
				  <ci>ito_f_infinity</ci>
				  <ci>ito_f</ci>
               </apply>
			   <ci>tau_ito_f</ci>
            </apply>
		 </apply>
		 
		 <apply>
            <eq/>
			<ci>ito_f_infinity</ci>
			<apply>
               <divide/>
			   <ci>alpha_i</ci>
			   <apply>
                  <plus/>
			      <ci>alpha_i</ci>
				  <ci>beta_i</ci>
			   </apply>
			</apply>
		 </apply>
			
	     <apply>
            <eq/>
            <ci>tau_ito_f</ci>
            <apply>
               <divide/>
			   <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000152</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                           </apply>
                        </apply>
                     </apply>
					 <apply>
                        <plus/>
						<apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.067083</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                              </apply>
                           </apply>
						</apply>
						<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
				  </apply>
				  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00095</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                           </apply>
                        </apply>
                     </apply>
					 <apply>
                        <plus/>
						<apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.051335</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                              </apply>
                           </apply>
						</apply>
						<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
				  </apply>
               </apply>
			</apply>
         </apply>
		 
		 <apply>
            <eq/>
            <ci>alpha_a</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.18064</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>beta_a</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.3956</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06237</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>alpha_i</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.000152</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">3.81</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.75</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0067083</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">132.05</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.75</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>beta_i</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.00095</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">132.05</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.75</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.051335</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">132.05</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.75</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="ultra_rapidly_activating_delayed_rectifier_potassium_current">
      <variable cmeta:id="ultra_rapidly_activating_delayed_rectifier_potassium_current_i_Kur" name="i_Kur" public_interface="out" units="picoA_per_picoF"/>
      <variable name="ass" public_interface="out" units="dimensionless"/>
	  
	  <variable initial_value="0.0048" name="g_Kur" units="milliS_per_microF"/>
      <variable initial_value="5.2471e-4" name="aur" units="dimensionless"/>
      <variable initial_value="0.9866" name="iur" units="dimensionless"/>
      <variable name="tau_aur" units="millisecond"/>
      <variable name="tau_iur" units="millisecond"/>
      <variable name="iss" units="dimensionless"/>
	  
	  <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kur</ci>
            <apply>
               <times/>
               <ci>g_Kur</ci>
               <ci>aur</ci>
               <ci>iur</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>aur</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ass</ci>
                  <ci>aur</ci>
               </apply>
               <ci>tau_aur</ci>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>iur</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>iss</ci>
                  <ci>iur</ci>
               </apply>
               <ci>tau_iur</ci>
            </apply>
         </apply>
		 
		 <apply>
            <eq/>
            <ci>ass</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>tau_aur</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.493</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0629</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2.058</cn>
            </apply>
         </apply>
		 
		 <apply>
            <eq/>
            <ci>iss</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.2</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>tau_iur</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1200</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">170</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.2</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.7</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="non_inactivating_steady_state_potassium_current">
      <variable cmeta:id="non_inactivating_steady_state_potassium_current_i_Kss" name="i_Kss" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="0.015" name="g_Kss" units="milliS_per_microF"/>
      <variable initial_value="0.8500" name="aKss" units="dimensionless"/>
      <variable name="tau_Kss" units="millisecond"/>
      
	  <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="ass" public_interface="in" units="dimensionless"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kss</ci>
            <apply>
               <times/>
               <ci>g_Kss</ci>
               <ci>aKss</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>aKss</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ass</ci>
                  <ci>aKss</ci>
               </apply>
               <ci>tau_Kss</ci>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>tau_Kss</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">39.3</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0862</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">13.17</cn>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="time_independent_potassium_current">
      <variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="0.235" name="g_K1" units="milliS_per_microF"/>
	  
	  <variable name="Ko" public_interface="in" units="micromolar"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
			   <ci>g_K1</ci>
			   <apply>
                  <divide/>
                  <ci>Ko</ci>
                  <apply>
                     <plus/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">210</cn>
                  </apply>
               </apply>
			   <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>V</ci>
                     <ci>E_K</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0896</cn>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
						   </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="slow_delayed_rectifier_potassium_current">
      <variable cmeta:id="slow_delayed_rectifier_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="0.046" name="g_Ks" units="milliS_per_microF"/>
      <variable initial_value="0.0026" name="nKs" units="dimensionless"/>
      <variable name="alpha_n" units="per_millisecond"/>
      <variable name="beta_n" units="per_millisecond"/>
      
	  <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <apply>
                  <power/>
                  <ci>nKs</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>nKs</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_n</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>nKs</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_n</ci>
                  <ci>nKs</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>alpha_n</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.00000481333</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.128</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
       
   	     <apply>
            <eq/>
            <ci>beta_n</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0000953333</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.038</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
  
   <component name="rapid_delayed_rectifier_potassium_current">
      <variable cmeta:id="rapid_delayed_rectifier_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="01.17" name="g_Kr" units="milliS_per_microF"/>
      <variable initial_value="2.1e-3" name="O_K" units="dimensionless"/>
      <variable initial_value="1.1e-3" name="C_K1" units="dimensionless"/>
      <variable initial_value="8.3641e-4" name="C_K2" units="dimensionless"/>
      <variable name="C_K0" units="dimensionless"/>
      <variable initial_value="4.3522e-4" name="I_K" units="dimensionless"/>
      <variable name="alpha_a0" units="per_millisecond"/>
      <variable name="beta_a0" units="per_millisecond"/>
      <variable initial_value="0.036778" name="kb" units="per_millisecond"/>
      <variable initial_value="0.023761" name="kf" units="per_millisecond"/>
      <variable name="alpha_a1" units="per_millisecond"/>
      <variable name="beta_a1" units="per_millisecond"/>
      <variable name="alpha_i" units="per_millisecond"/>
      <variable name="beta_i" units="per_millisecond"/>
      
	  <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
	  <variable name="E_K" public_interface="in" units="millivolt"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <ci>O_K</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>C_K0</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>C_K1</ci>
                  <ci>C_K2</ci>
                  <ci>O_K</ci>
                  <ci>I_K</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_K2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>kf</ci>
                     <ci>C_K1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_a1</ci>
                     <ci>O_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>kb</ci>
                     <ci>C_K2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_a1</ci>
                     <ci>C_K2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_K1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_a0</ci>
                     <ci>C_K0</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kb</ci>
                     <ci>C_K2</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_a0</ci>
                     <ci>C_K1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kf</ci>
                     <ci>C_K1</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O_K</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_a1</ci>
                     <ci>C_K2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_i</ci>
                     <ci>I_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_a1</ci>
                     <ci>O_K</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_i</ci>
                     <ci>O_K</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I_K</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_i</ci>
                  <ci>O_K</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_i</ci>
                  <ci>I_K</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>alpha_a0</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.022348</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01176</cn>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>beta_a0</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.047002</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0631</cn>
                     </apply>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>alpha_a1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.013733</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.038198</cn>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
        
 		 <apply>
            <eq/>
            <ci>beta_a1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0000689</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04178</cn>
                     </apply>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>alpha_i</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.090821</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.023391</cn>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>beta_i</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.006497</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03268</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="sodium_potassium_pump_current">
      <variable cmeta:id="sodium_potassium_pump_current_i_NaK" name="i_NaK" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="0.88" name="i_NaK_max" units="picoA_per_picoF"/>
      <variable initial_value="21000" name="Km_Nai" units="micromolar"/>
      <variable initial_value="1500" name="Km_Ko" units="micromolar"/>
      <variable name="f_NaK" units="dimensionless"/>
      <variable name="sigma" units="dimensionless"/>
      
	  <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Nai" public_interface="in" units="micromolar"/>
      <variable name="Nao" public_interface="in" units="micromolar"/>
      <variable name="Ko" public_interface="in" units="micromolar"/>
     
 	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>i_NaK_max</ci>
                        <ci>f_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Km_Nai</ci>
                              <ci>Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Ko</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>Km_Ko</ci>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         
		 <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">67300</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <component name="calcium_activated_chloride_current">
      <variable cmeta:id="calcium_activated_chloride_current_i_ClCa" name="i_ClCa" public_interface="out" units="picoA_per_picoF"/>
      
	  <variable initial_value="2.74e-7" name="P_ClCa" units="cm_per_second"/>
      <variable name="f_ClCa" units="dimensionless"/>
      <variable initial_value="4" name="Km_Cl" units="micromolar"/>
	  <variable initial_value="3" name="n_ClCa" units="dimensionless"/>
      
	  <variable name="V" public_interface="in" units="millivolt"/>
	  <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Cli" public_interface="in" units="micromolar"/>
	  <variable name="Clo" public_interface="in" units="micromolar"/>
	  <variable name="Cass" public_interface="in" units="micromolar"/>
      
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_ClCa</ci>
            <apply>
               <power/>
			   <apply>
                  <divide/>
				  <ci>Cass</ci>
                  <apply>
                     <plus/>
                     <ci>Km_Cl</ci>
					 <ci>Cass</ci>
				  </apply>
			   </apply>
			   <ci>n_ClCa</ci>
			</apply>
         </apply>
					 
		 <apply>
            <eq/>
            <ci>i_ClCa</ci>
            <apply>
               <times/>
			   <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="cm2_per_microF">1</cn>
			   <ci>P_ClCa</ci>
               <ci>f_ClCa</ci>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>V</ci>
					 <apply>
                        <power/>
                        <ci>F</ci>
						<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
				  </apply>
				  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
               </apply>
			   <apply>
                  <divide/>
				  <apply>
                     <minus/>
                     <apply>
                        <times/>
						<ci>Clo</ci>
						<apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
								 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
							  <apply>
                                 <times/>
								 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
						   </apply>
						</apply>
				     </apply>
					 <ci>Cli</ci>
				  </apply>
                  <apply>
                     <minus/>
					 <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
					          <ci>V</ci>
                              <ci>F</ci>
                           </apply>
						   <apply>
                              <times/>
							  <ci>R</ci>
                              <ci>T</ci>
                           </apply>
						</apply>
				     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="T_type_calcium_current">
         <component_ref component="T_type_calcium_current_b_gate"/>
         <component_ref component="T_type_calcium_current_g_gate"/>
      </component_ref>
   </group>
   
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_fluxes" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_buffering" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ryanodine_receptors" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_calcium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="T_type_calcium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_concentration" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_outward_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ultra_rapidly_activating_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="non_inactivating_steady_state_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="L_type_calcium_current"/>
      <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="T_type_calcium_current"/>
      <map_variables variable_1="i_CaT" variable_2="i_CaT"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_pump_current"/>
      <map_variables variable_1="i_pCa" variable_2="i_pCa"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_calcium_exchange_current"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_background_current"/>
      <map_variables variable_1="i_Cab" variable_2="i_Cab"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="fast_sodium_current"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_background_current"/>
      <map_variables variable_1="i_Nab" variable_2="i_Nab"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_potassium_pump_current"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
	  <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="fast_transient_outward_potassium_current"/>
      <map_variables variable_1="i_Kto_f" variable_2="i_Kto_f"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="ultra_rapidly_activating_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="i_Kur" variable_2="i_Kur"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="non_inactivating_steady_state_potassium_current"/>
      <map_variables variable_1="i_Kss" variable_2="i_Kss"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_activated_chloride_current"/>
      <map_variables variable_1="i_ClCa" variable_2="i_ClCa"/>
      <map_variables variable_1="V" variable_2="V"/>
	  <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
	  <map_variables variable_1="Clo" variable_2="Clo"/>
      <map_variables variable_1="Cli" variable_2="Cli"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_concentration"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="Acap" variable_2="Acap"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
      <map_variables variable_1="VNSR" variable_2="VNSR"/>
      <map_variables variable_1="VJSR" variable_2="VJSR"/>
      <map_variables variable_1="Vss" variable_2="Vss"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_fluxes"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_concentration"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
      <map_variables variable_1="Acap" variable_2="Acap"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="potassium_concentration"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
      <map_variables variable_1="Acap" variable_2="Acap"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="calcium_fluxes"/>
      <map_variables variable_1="Cass" variable_2="Cass"/>
      <map_variables variable_1="CaJSR" variable_2="CaJSR"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="CaNSR" variable_2="CaNSR"/>
      <map_variables variable_1="J_rel" variable_2="J_rel"/>
      <map_variables variable_1="J_tr" variable_2="J_tr"/>
      <map_variables variable_1="J_xfer" variable_2="J_xfer"/>
      <map_variables variable_1="J_leak" variable_2="J_leak"/>
      <map_variables variable_1="J_up" variable_2="J_up"/>
      <map_variables variable_1="J_trpn" variable_2="J_trpn"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="calcium_buffering"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="ryanodine_receptors"/>
      <map_variables variable_1="Cass" variable_2="Cass"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="L_type_calcium_current"/>
      <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
      <map_variables variable_1="Cass" variable_2="Cass"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="T_type_calcium_current"/>
      <map_variables variable_1="i_CaT" variable_2="i_CaT"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="calcium_pump_current"/>
      <map_variables variable_1="i_pCa" variable_2="i_pCa"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="sodium_calcium_exchange_current"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="calcium_background_current"/>
      <map_variables variable_1="i_Cab" variable_2="i_Cab"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="calcium_activated_chloride_current"/>
      <map_variables variable_1="Cass" variable_2="Cass"/>
   </connection>
   <connection>
      <map_components component_1="calcium_fluxes" component_2="calcium_buffering"/>
      <map_variables variable_1="LTRPN_tot" variable_2="LTRPN_tot"/>
      <map_variables variable_1="HTRPN_tot" variable_2="HTRPN_tot"/>
      <map_variables variable_1="LTRPN_Ca" variable_2="LTRPN_Ca"/>
      <map_variables variable_1="HTRPN_Ca" variable_2="HTRPN_Ca"/>
      <map_variables variable_1="k_plus_htrpn" variable_2="k_plus_htrpn"/>
      <map_variables variable_1="k_minus_htrpn" variable_2="k_minus_htrpn"/>
      <map_variables variable_1="k_plus_ltrpn" variable_2="k_plus_ltrpn"/>
      <map_variables variable_1="k_minus_ltrpn" variable_2="k_minus_ltrpn"/>
   </connection>
   <connection>
      <map_components component_1="calcium_fluxes" component_2="L_type_calcium_current"/>
      <map_variables variable_1="i_CaL_max" variable_2="i_CaL_max"/>
      <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
   </connection>
   <connection>
      <map_components component_1="calcium_fluxes" component_2="ryanodine_receptors"/>
      <map_variables variable_1="P_O1" variable_2="P_O1"/>
      <map_variables variable_1="P_O2" variable_2="P_O2"/>
   </connection>
   <connection>
      <map_components component_1="sodium_concentration" component_2="fast_sodium_current"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="sodium_concentration" component_2="sodium_background_current"/>
      <map_variables variable_1="i_Nab" variable_2="i_Nab"/>
   </connection>
   <connection>
      <map_components component_1="sodium_concentration" component_2="sodium_calcium_exchange_current"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="sodium_concentration" component_2="sodium_potassium_pump_current"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="fast_transient_outward_potassium_current"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="i_Kto_f" variable_2="i_Kto_f"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="ultra_rapidly_activating_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="i_Kur" variable_2="i_Kur"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="sodium_potassium_pump_current"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="ultra_rapidly_activating_delayed_rectifier_potassium_current" component_2="non_inactivating_steady_state_potassium_current"/>
      <map_variables variable_1="ass" variable_2="ass"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="non_inactivating_steady_state_potassium_current"/>
      <map_variables variable_1="i_Kss" variable_2="i_Kss"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_outward_potassium_current" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_outward_potassium_current" component_2="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_outward_potassium_current" component_2="ultra_rapidly_activating_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_outward_potassium_current" component_2="non_inactivating_steady_state_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_outward_potassium_current" component_2="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
      <map_variables variable_1="m" variable_2="m"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
      <map_variables variable_1="h" variable_2="h"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
      <map_variables variable_1="j" variable_2="j"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="T_type_calcium_current" component_2="T_type_calcium_current_b_gate"/>
      <map_variables variable_1="b" variable_2="b"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="T_type_calcium_current" component_2="T_type_calcium_current_g_gate"/>
      <map_variables variable_1="g" variable_2="g"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>


<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="#wang_model_2008"><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n1"/></simulation><cmeta:comment><rdf:Description rdf:about="rdf:#09c152f3-5f44-41ce-bad8-175e6f27bf86"/></cmeta:comment><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#d0769982-0d4d-4d65-a54e-462d65917001"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n2"/></reference></rdf:Description><rdf:Description rdf:about="rdf:#af27a0fa-7d17-43df-a49b-7e01d8a1c114"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2008-04-11 00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#8ea3fb69-ae8b-4e35-80e4-372ce3abed38"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Wang</Family><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">J</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Linda</Given></rdf:Description><rdf:Description rdf:about="rdf:#caf953e9-03ae-44e2-a1f3-5edbd2d3c6c7"><ORG xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#632aec73-3b6c-4e1c-a245-49a7b52af31d"/></ORG><EMAIL xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#d25fefba-6be1-4fc9-80ef-ade4d3798d48"/></EMAIL><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#7cd164da-489d-43b3-ac26-575850200ade"/></N></rdf:Description><rdf:Description rdf:nodeID="n3"><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest><rdf:first><rdf:Description rdf:nodeID="n4"/></rdf:first></rdf:Description><rdf:Description rdf:about="rdf:#50781470-62a2-46f6-a423-b72a35b34587"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#6c03d419-e71e-403d-9074-48fa3afe93de"/></creator><rdf:value xml:lang="en">This CellML model is known to run in PCEnv and COR to recreate the published results. The units have been checked and are consistent.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#19e7066e-d983-4408-b59a-bd31a1ef5189"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#7d52f800-28d5-464b-9904-191c0468798c"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:nodeID="n1"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n3"/></boundIntervals></rdf:Description><rdf:Description rdf:about="rdf:#4d0294d5-dd3e-4677-88c1-b641f2d1d3a8"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2009-03-02T00:00:00+00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#d77fcb00-54a6-4792-b702-dde28a037fd5"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en"></FN></rdf:Description><rdf:Description rdf:about="rdf:#d25fefba-6be1-4fc9-80ef-ade4d3798d48"><rdf:value xml:lang="en">c.lloyd@auckland.ac.nz</rdf:value><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#7d52f800-28d5-464b-9904-191c0468798c"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Sobie</Family><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">A</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Eric</Given></rdf:Description><rdf:Description rdf:about=""><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#caf953e9-03ae-44e2-a1f3-5edbd2d3c6c7"/></creator><created xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#4d0294d5-dd3e-4677-88c1-b641f2d1d3a8"/></created><publisher xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en"></publisher><cmeta:comment><rdf:Description rdf:about="rdf:#50781470-62a2-46f6-a423-b72a35b34587"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#9f4e73fd-4d59-471e-a9d5-4efb22972e41"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Mathematical model of the neonatal mouse ventricular action potential</title><Journal xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#1c62e8db-6d60-4a8b-828d-016d4b882233"/></Journal><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#0b6e6fb8-9e67-4163-8f2a-125b2973d05e"/></creator><last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">H2575</last_page><volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">294</volume><issued xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#af27a0fa-7d17-43df-a49b-7e01d8a1c114"/></issued><first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">H2565</first_page></rdf:Description><rdf:Description rdf:about="rdf:#0b6e6fb8-9e67-4163-8f2a-125b2973d05e"><rdf:_2><rdf:Description rdf:about="rdf:#19e7066e-d983-4408-b59a-bd31a1ef5189"/></rdf:_2><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type><rdf:_1><rdf:Description rdf:about="rdf:#6685a93f-c980-4fa3-b78e-cd112c11390e"/></rdf:_1></rdf:Description><rdf:Description rdf:about="rdf:#d0769982-0d4d-4d65-a54e-462d65917001"><Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">18408122</Pubmed_id><JournalArticle xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#9f4e73fd-4d59-471e-a9d5-4efb22972e41"/></JournalArticle></rdf:Description><rdf:Description rdf:about="rdf:#1c62e8db-6d60-4a8b-828d-016d4b882233"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">American Journal of Physiology Heart and Circulatory Physiology</title></rdf:Description><rdf:Description rdf:about="rdf:#09c152f3-5f44-41ce-bad8-175e6f27bf86"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#d77fcb00-54a6-4792-b702-dde28a037fd5"/></creator><rdf:value xml:lang="en"></rdf:value></rdf:Description><rdf:Description rdf:nodeID="n2"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n5"/></subject></rdf:Description><rdf:Description rdf:nodeID="n4"><maximumStepSize xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">0.1</maximumStepSize><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">120</endingValue><pointDensity xmlns="http://www.cellml.org/metadata/simulation/1.0#nonstandard-" xml:lang="en">10000</pointDensity></rdf:Description><rdf:Description rdf:about="rdf:#6c03d419-e71e-403d-9074-48fa3afe93de"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine Lloyd</FN></rdf:Description><rdf:Description rdf:about="rdf:#6685a93f-c980-4fa3-b78e-cd112c11390e"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#8ea3fb69-ae8b-4e35-80e4-372ce3abed38"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#632aec73-3b6c-4e1c-a245-49a7b52af31d"><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Auckland Bioengineering Institute</Orgunit><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The University of Auckland</Orgname></rdf:Description><rdf:Description rdf:nodeID="n6"><rdf:_2 xml:lang="en">calcium dynamics</rdf:_2><rdf:_3 xml:lang="en">myocyte</rdf:_3><rdf:_4 xml:lang="en">mouse</rdf:_4><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/></rdf:type><rdf:_1 xml:lang="en">electrophysiology</rdf:_1><rdf:_5 xml:lang="en">myocardium</rdf:_5></rdf:Description><rdf:Description rdf:nodeID="n5"><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type><rdf:value><rdf:Description rdf:nodeID="n6"/></rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#7cd164da-489d-43b3-ac26-575850200ade"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given></rdf:Description></rdf:RDF></model>