Location: Vancapelle, Durrer, 1980 @ 6a9f5cb0a5c2 / vancapelle_durrer_1980.cellml

Author:
pmr2.import <nobody@models.cellml.org>
Date:
2009-06-17 16:16:23+12:00
Desc:
committing version02 of vancapelle_durrer_1980
Permanent Source URI:
https://models.physiomeproject.org/workspace/vancapelle_durrer_1980/rawfile/6a9f5cb0a5c25e2ec9640b6a201a889ad72673ba/vancapelle_durrer_1980.cellml

<?xml version='1.0' encoding='utf-8'?>
<!--  FILE :  van_capelle_durrer_model_1980.xml

CREATED :  28th December 2001

LAST MODIFIED : 9th April 2003

AUTHOR :  Catherine Lloyd
          Department of Engineering Science
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification.

DESCRIPTION :  This file contains a CellML description of van Capelle and
Durrer's 1980 simplified model of cardiac myocytes.

CHANGES: 
  21/01/2002 - AAC - Updated metadata to conform to the 16/1/02 CellML Metadata
                     1.0 Specification.
  22/07/2002 - CML - Added more metadata.
  09/04/2003 - AAC - Added publication date information.  
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>The van Capelle-Durrer Simplified Cardiac Myocyte Model</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This is the original unchecked version of the model imported from the previous
            CellML model repository, 24-Jan-2006.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
Often it is not necessary to model the ionic currents of a cell with the accuracy and complexity inherent in the biophysically based models.  With a view to investigating phenomena on a larger spatial and temporal scale, several ionic current models have been developed that do not seek to model subcellular processes but only to provide an action potential at a minimal computational cost. 
</para>

<para>
The model created by van Capelle and Durrer (1980) follows the same general form as the FitzHugh-Nagumo model (see <ulink url="${HTML_EXMPL_FN_SIMPLE}">The FitzHugh-Nagumo Model, 1961</ulink>), with a single activation variable and a single recovery variable.  It also includes the ability to add more complex parameter representations.
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
<ulink url="http://circres.ahajournals.org/cgi/content/abstract/47/3/454">Computer simulation of arrhythmias in a network of coupled excitable elements</ulink>, van Capelle, F.J.L., Durrer, D., 1980, <ulink url="http://circres.ahajournals.org/">
            <emphasis>Circ. Res.</emphasis>
          </ulink>, 47, 454-466.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=7408126&amp;dopt=Abstract">PubMed ID: 7408126</ulink>
</para>

<para>
The raw CellML description of the simplified cardiac myocyte models can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.  For an example of a more complete documentation for an electrophysiological model, see <ulink url="${HTML_EXMPL_HHSA_INTRO}">The Hodgkin-Huxley Squid Axon Model, 1952</ulink>. 
</para>

</sect1>
</article>
</documentation>
  
  
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        The van Capelle-Durrer Simplified Model of a Cardiac Myocyte
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