Location: Teusink, Passarge, Reijenga, Esgalhado, Vanderweijden, Schepper, Walsh, Bakker, Vandam, Westerhoff, Snoep, 2000 @ 452129d229a3 / teusink_passarge_reijenga_esgalhado_vanderweijden_schepper_walsh_bakker_vandam_westerhoff_snoep_2000.cellml

Author:
Catherine Lloyd <c.lloyd@auckland.ac.nz>
Date:
2010-06-01 21:37:21+12:00
Desc:
Added annotated version of the model to the workspace.
Permanent Source URI:
https://models.physiomeproject.org/workspace/teusink_passarge_reijenga_esgalhado_vanderweijden_schepper_walsh_bakker_vandam_westerhoff_snoep_2000/rawfile/452129d229a37abd04a3dd1e8ba1ee863c47f79f/teusink_passarge_reijenga_esgalhado_vanderweijden_schepper_walsh_bakker_vandam_westerhoff_snoep_2000.cellml

<?xml version="1.0"?>
<!--  FILE :  teusink_model_2000.xml

CREATED :  12th May 2003

LAST MODIFIED : 20th April 2005

AUTHOR :  Catherine Lloyd
          Bioengineering Institute
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.

DESCRIPTION :  This file contains a CellML description of Teusink et al.'s 2000 model for glycolysis in yeast.

CHANGES:  
  20/04/2005 - PJV - Updated syntax to conform with cellml1.1 specs
  
-->
<model xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="teusink_model_2000" cmeta:id="teusink_model_2000" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">


<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This CellML runs in both OpenCell and COR to recreate the published results.  The units have been checked and they are consistent.  This particular CellML model is based on a Matlab file which, in turn, was exported from the working SBML file in the BioModels database.  There are several subtle differences between the published paper and the working Matlab code which have been previously documented by the BioModels curators.  In brief these are:
			in the kinetic law for ADH the species a should denote NAD and b Ethanol the last term in the equation should read bpq/(Kib Kiq Kp) and the rate equation for the PFK contains two errors: the R term should read: R = 1 + lambda1 + lambda2 + gR lambda1 lambda2 and the last term in the L equation should be squared.
			Also there are slight differences in the parameterisation of the model depending on whether it comes from the JWS or the BioModels database and, for Vmax values, please note that there is a conversion factor of approxinately 270 to convert from U/mg-protein as shown in Table 1 of the paper to mmol/(min*L_cytosol).
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
ABSTRACT: This paper examines whether the in vivo behavior of yeast glycolysis can be understood in terms of the in vitro kinetic properties of the constituent enzymes. In nongrowing, anaerobic, compressed Saccharomyces cerevisiae the values of the kinetic parameters of most glycolytic enzymes were determined. For the other enzymes appropriate literature values were collected. By inserting these values into a kinetic model for glycolysis, fluxes and metabolites were calculated. Under the same conditions fluxes and metabolite levels were measured. In our first model, branch reactions were ignored. This model failed to reach the stable steady state that was observed in the experimental flux measurements. Introduction of branches towards trehalose, glycogen, glycerol and succinate did allow such a steady state. The predictions of this branched model were compared with the empirical behavior. Half of the enzymes matched their predicted flux in vivo within a factor of 2. For the other enzymes it was calculated what deviation between in vivo and in vitro kinetic characteristics could explain the discrepancy between in vitro rate and in vivo flux.
</para>

<para>
The original paper reference is cited below:
</para>

<para>
Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry, Bas Teusink, Jutta Passarge, Corinne A. Reijenga, Eugenia Esgalhado, Coen C. van der Weijden, Mike Schepper, Michael C. Walsh, Barbara M. Bakker, Karel van Dam, Hans V. Westerhoff, and Jacky L. Snoep, 2000, <emphasis>European Journal of Biochemistry</emphasis>, 267, 5313-5329.  <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/10951190">PubMed ID: 10951190</ulink>
</para>

<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>reaction diagram</title>
    </objectinfo>
    <imagedata fileref="teusink_2000.png"/>
  </imageobject>
</mediaobject>
<caption>Schematic diagram of the glycolysis pathway model described by Teusink et al. 2000. Reactions in boxes show the branches introduced in the extended model.</caption>
</informalfigure>

</sect1>
</article>
</documentation>
  
  
  <units name="millimolar">
    <unit prefix="milli" units="mole"/>
    <unit exponent="-1" units="litre"/>
  </units>
  
  <units name="millimolar2">
    <unit exponent="2" units="millimolar"/>
  </units>
  
  <units name="per_millimolar2">
    <unit exponent="-2" units="millimolar"/>
  </units>
  
  <units name="minute">
    <unit multiplier="60.0" units="second"/>
  </units>
  
  <units name="flux">
    <unit units="millimolar"/>
    <unit exponent="-1" units="minute"/>
  </units>
  
  <units name="first_order_rate_constant">
    <unit exponent="-1" units="minute"/>
  </units>
  
  
  <component name="environment">
    <variable cmeta:id="environment_time" name="time" public_interface="out" units="minute"/>
  </component>
 
  
  <component cmeta:id="GLCo" name="GLCo">
     
    <variable cmeta:id="GLCo_GLCo" initial_value="50.0" name="GLCo" public_interface="out" units="millimolar"/> 
  </component>
  
  <component cmeta:id="GLCi" name="GLCi">
     
    <variable cmeta:id="GLCi_GLCi" initial_value="0.087" name="GLCi" public_interface="out" units="millimolar"/> 
    <variable name="v_GLT" public_interface="in" units="flux"/>
    <variable name="v_GLK" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="2"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci> time </ci>
          </bvar> 
          <ci> GLCi </ci> 
        </apply>
        <apply>
          <minus/> 
          <ci> v_GLT </ci>
          <ci> v_GLK </ci>
        </apply> 
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="G6P" name="G6P">
     
    <variable cmeta:id="G6P_G6P" initial_value="2.45" name="G6P" public_interface="out" units="millimolar"/>
    <variable name="v_GLK" public_interface="in" units="flux"/> 
    <variable name="v_PGI" public_interface="in" units="flux"/>
    <variable name="v_trehalose" public_interface="in" units="flux"/>
    <variable name="v_glycogen" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="3"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>G6P</ci> 
        </apply>
        <apply>
          <minus/>
          <ci> v_GLK </ci>
          <apply>
            <plus/>
            <ci> v_PGI </ci>
            <apply>
              <times/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
              <ci> v_trehalose </ci>
            </apply>
            <ci> v_glycogen </ci>
          </apply>
        </apply> 
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="F6P" name="F6P">
     
    <variable cmeta:id="F6P_F6P" initial_value="0.62" name="F6P" public_interface="out" units="millimolar"/> 
    <variable name="v_PGI" public_interface="in" units="flux"/>
    <variable name="v_PFK" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="4"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>F6P</ci> 
        </apply>
        <apply>
          <minus/> 
          <ci>v_PGI</ci>
          <ci>v_PFK</ci>
        </apply> 
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="F16P" name="F16P">
     
    <variable cmeta:id="F16P_F16P" initial_value="5.51" name="F16P" public_interface="out" units="millimolar"/> 
    <variable name="v_PFK" public_interface="in" units="flux"/>
    <variable name="v_ALD" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="5"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>F16P</ci> 
        </apply>
        <apply>
          <minus/> 
          <ci>v_PFK</ci>
          <ci>v_ALD</ci>
        </apply> 
      </apply> 
    </math> 
  </component>

  <component cmeta:id="F26P" name="F26P">
     
    <variable initial_value="0.02" name="F26P" public_interface="out" units="millimolar"/> 
  </component>
  
  <component cmeta:id="TRIO" name="TRIO">
     
    <variable cmeta:id="TRIO_TRIO" initial_value="0.96" name="TRIO" public_interface="out" units="millimolar"/>
    <variable name="v_ALD" public_interface="in" units="flux"/> 
    <variable name="v_GAPDH" public_interface="in" units="flux"/>
    <variable name="v_G3PDH" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="6"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>TRIO</ci> 
        </apply>
        <apply>
          <minus/>
          <apply>
            <times/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
            <ci> v_ALD </ci>
          </apply>
          <apply>
            <plus/>
            <ci> v_GAPDH </ci>
            <ci> v_G3PDH </ci>
          </apply>
        </apply> 
      </apply> 
    </math> 
  </component>

  <component cmeta:id="BPG" name="BPG">
     
    <variable cmeta:id="BPG_BPG" initial_value="0.0" name="BPG" public_interface="out" units="millimolar"/> 
    <variable name="v_GAPDH" public_interface="in" units="flux"/>
    <variable name="v_PGK" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="7"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>BPG</ci> 
        </apply>
        <apply>
          <minus/> 
          <ci>v_GAPDH</ci>
          <ci>v_PGK</ci>
        </apply> 
      </apply> 
    </math> 
  </component>

  <component cmeta:id="P3G" name="P3G">
     
    <variable cmeta:id="P3G_P3G" initial_value="0.9" name="P3G" public_interface="out" units="millimolar"/> 
    <variable name="v_PGK" public_interface="in" units="flux"/>
    <variable name="v_PGM" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="8"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>P3G</ci> 
        </apply>
        <apply>
          <minus/> 
          <ci>v_PGK</ci>
          <ci>v_PGM</ci>
        </apply> 
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="P2G" name="P2G">
     
    <variable cmeta:id="P2G_P2G" initial_value="0.12" name="P2G" public_interface="out" units="millimolar"/> 
    <variable name="v_PGM" public_interface="in" units="flux"/>
    <variable name="v_ENO" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="9"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>P2G</ci> 
        </apply>
        <apply>
          <minus/> 
          <ci>v_PGM</ci>
          <ci>v_ENO</ci>
        </apply> 
      </apply> 
    </math> 
  </component>

  <component cmeta:id="PEP" name="PEP">
     
    <variable cmeta:id="PEP_PEP" initial_value="0.07" name="PEP" public_interface="out" units="millimolar"/> 
    <variable name="v_ENO" public_interface="in" units="flux"/>
    <variable name="v_PYK" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="10"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>PEP</ci> 
        </apply>
        <apply>
          <minus/> 
          <ci>v_ENO</ci>
          <ci>v_PYK</ci>
        </apply> 
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="PYR" name="PYR">
     
    <variable cmeta:id="PYR_PYR" initial_value="1.85" name="PYR" public_interface="out" units="millimolar"/> 
    <variable name="v_PYK" public_interface="in" units="flux"/>
    <variable name="v_PDC" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="11"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>PYR</ci> 
        </apply>
        <apply>
          <minus/> 
          <ci>v_PYK</ci>
          <ci>v_PDC</ci>
        </apply> 
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="ACE" name="ACE">
     
    <variable initial_value="0.17" name="ACE" public_interface="out" units="millimolar"/> 
    <variable name="v_PDC" public_interface="in" units="flux"/>
    <variable name="v_ADH" public_interface="in" units="flux"/>
    <variable name="v_succinate" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="12"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>ACE</ci> 
        </apply>
        <apply>
          <minus/> 
          <ci>v_PDC</ci>
          <apply>
            <plus/>
            <ci>v_ADH</ci>
            <apply>
              <times/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
              <ci>v_succinate</ci>
            </apply>
          </apply>
        </apply> 
      </apply> 
    </math> 
  </component>
  
  <component cmeta:id="P" name="P">
     
    <variable initial_value="6.31" name="P" public_interface="out" units="millimolar"/>
    
	<variable name="v_GLK" public_interface="in" units="flux"/>
    <variable name="v_PFK" public_interface="in" units="flux"/>
    <variable name="v_PGK" public_interface="in" units="flux"/>
    <variable name="v_PYK" public_interface="in" units="flux"/>
    <variable name="v_ATP" public_interface="in" units="flux"/>
    <variable name="v_trehalose" public_interface="in" units="flux"/>
    <variable name="v_glycogen" public_interface="in" units="flux"/>
    <variable name="v_succinate" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/>
    
	<math xmlns="http://www.w3.org/1998/Math/MathML" id="13"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>P</ci> 
        </apply>
        <apply>
          <minus/>
          <apply>
            <plus/>  
            <ci> v_PGK </ci>
            <ci> v_PYK </ci>
          </apply>
          <apply>
            <plus/>  
            <ci> v_GLK </ci>
            <ci> v_PFK </ci>
            <ci> v_ATP </ci>
            <ci> v_trehalose </ci>
            <ci> v_glycogen </ci>
            <apply>
              <times/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 4.0 </cn>
              <ci>v_succinate</ci>
            </apply>
          </apply>
        </apply> 
      </apply> 
    </math>
  </component>
		
  <component cmeta:id="NADH" name="NADH">
     
    <variable cmeta:id="NADH_NADH" initial_value="0.39" name="NADH" public_interface="out" units="millimolar"/> 
    <variable name="v_GAPDH" public_interface="in" units="flux"/>
    <variable name="v_ADH" public_interface="in" units="flux"/>
    <variable name="v_G3PDH" public_interface="in" units="flux"/>
    <variable name="v_succinate" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="14"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>NADH</ci> 
        </apply> 
        <apply>
          <minus/>
          <apply>
            <plus/>
			<ci>v_GAPDH</ci>
			<apply>
              <times/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
              <ci>v_succinate</ci>
            </apply>
		  </apply>
          <apply>
            <plus/>
            <ci>v_ADH</ci>
            <ci>v_G3PDH</ci>
          </apply>
        </apply> 
      </apply>
    </math> 
  </component>

  <component cmeta:id="NAD" name="NAD">
     
    <variable cmeta:id="NAD_NAD" initial_value="1.20" name="NAD" public_interface="out" units="millimolar"/>
    <variable name="v_GAPDH" public_interface="in" units="flux"/>
    <variable name="v_ADH" public_interface="in" units="flux"/>
    <variable name="v_G3PDH" public_interface="in" units="flux"/>
    <variable name="v_succinate" public_interface="in" units="flux"/>
    <variable name="time" public_interface="in" units="minute"/> 
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="15"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci>NAD</ci> 
        </apply> 
        <apply>
          <minus/>
          <apply>
            <plus/>
            <ci>v_ADH</ci>
            <ci>v_G3PDH</ci>
          </apply>
		  <apply>
            <plus/>
            <ci>v_GAPDH</ci>
			<apply>
              <times/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 3.0 </cn>
              <ci>v_succinate</ci>
            </apply>
          </apply>
        </apply> 
      </apply>
    </math> 
  </component>

  <component name="DHAP"> 
    <variable cmeta:id="DHAP_DHAP" name="DHAP" public_interface="out" units="millimolar"/>
    <variable initial_value="0.045" name="Keq_TPI" public_interface="out" units="dimensionless"/>
    <variable name="TRIO" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="16">
      <apply>
        <eq/> 
        <ci>DHAP</ci> 
        <apply>
          <divide/>
          <ci>TRIO</ci> 
          <apply>
            <plus/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
            <ci>Keq_TPI</ci>
          </apply>
        </apply>
      </apply>
    </math> 
  </component>

  <component cmeta:id="GAP" name="GAP">
     
    <variable cmeta:id="GAP_GAP" name="GAP" public_interface="out" units="millimolar"/>
    <variable name="Keq_TPI" public_interface="in" units="dimensionless"/>
    <variable name="TRIO" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="17">
      <apply>
        <eq/> 
        <ci>GAP</ci> 
        <apply>
          <divide/>
          <apply>
            <times/>
            <ci>TRIO</ci> 
            <ci>Keq_TPI</ci>
          </apply>
          <apply>
            <plus/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
            <ci>Keq_TPI</ci>
          </apply>
        </apply>
      </apply>
    </math> 
  </component>
  
  <component cmeta:id="ADP" name="ADP">
     
    <variable cmeta:id="ADP_ADP" name="ADP" public_interface="out" units="millimolar"/>
	<variable initial_value="4.1" name="SUM_P" public_interface="out" units="millimolar"/>
	
	<variable initial_value="0.450" name="Keq_AK" units="dimensionless"/>
	
	<variable name="P" public_interface="in" units="millimolar"/>
    
	<math xmlns="http://www.w3.org/1998/Math/MathML" id="18"> 
      <apply><eq/> 
        <ci>ADP</ci>
        <apply><divide/>
          <apply><minus/> 
            <ci>SUM_P</ci>
			<apply><root/>
			  <apply><plus/>  
                <apply><times/> 
                  <apply><power/>
				    <ci>P</ci>
					<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2 </cn>
				  </apply>
                  <apply><minus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
                    <apply><times/> 
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 4.0 </cn>
                      <ci>Keq_AK</ci>
                    </apply>
				  </apply>
                </apply>
				<apply><times/> 
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2 </cn>
				  <ci>SUM_P</ci>
			      <ci>P</ci>
				  <apply><minus/>
				    <apply><times/> 
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 4.0 </cn>
                      <ci>Keq_AK</ci>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
				  </apply>
				</apply>
				<apply><power/>
				  <ci>SUM_P</ci>
			      <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2 </cn>
				</apply>
              </apply>
            </apply>  
		  </apply>
          <apply><minus/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
            <apply><times/> 
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 4.0 </cn>
              <ci>Keq_AK</ci>
            </apply>
          </apply>
        </apply> 
      </apply> 
    </math>
  </component>	
		
  <component cmeta:id="ATP" name="ATP">
     
    <variable cmeta:id="ATP_ATP" name="ATP" public_interface="out" units="millimolar"/>
    
    <variable name="P" public_interface="in" units="millimolar"/>
    <variable name="ADP" public_interface="in" units="millimolar"/>
    
	<math xmlns="http://www.w3.org/1998/Math/MathML" id="19"> 
      <apply><eq/> 
        <ci>ATP</ci> 
        <apply><divide/>
          <apply><minus/>
		    <ci>P</ci>
			<ci>ADP</ci>
		  </apply>
		  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2 </cn> 
        </apply>
      </apply>
    </math>
  </component>

  <component cmeta:id="AMP" name="AMP">
     
    <variable cmeta:id="AMP_AMP" name="AMP" public_interface="out" units="millimolar"/>
	
	<variable name="SUM_P" public_interface="in" units="millimolar"/>
	<variable name="ADP" public_interface="in" units="millimolar"/>
    <variable name="ATP" public_interface="in" units="millimolar"/>
    
	<math xmlns="http://www.w3.org/1998/Math/MathML" id="20"> 
      <apply><eq/> 
        <ci>AMP</ci> 
        <apply><minus/>
		  <ci>SUM_P</ci>
		  <apply><plus/>
		    <ci>ATP</ci>
            <ci>ADP</ci>
	      </apply>
		</apply>
      </apply>
    </math>
  </component>
  
  <component cmeta:id="ETOH" name="ETOH">
     
	<variable initial_value="50.0" name="ETOH" public_interface="out" units="millimolar"/>
  </component>
  
  <component cmeta:id="GLY" name="GLY">
    
    <variable cmeta:id="GLY_GLY" initial_value="0.15" name="GLY" public_interface="out" units="millimolar"/>
  </component>
  
  <!--
    The following components describe the reactions of the core, unbranched model.
  -->
  
  <component name="v_PGI">
    <variable name="v_PGI" public_interface="out" units="flux"/>
    
    <variable initial_value="1.4" name="Km_G6P" units="millimolar"/>
    <variable initial_value="0.3" name="Km_F6P" units="millimolar"/>
    <variable initial_value="0.314" name="Keq_PGI" units="dimensionless"/>
    <variable initial_value="339.677" name="v_max" units="flux"/>

    <variable name="G6P" public_interface="in" units="millimolar"/>
    <variable name="F6P" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="25">
      <apply id="v_PGI_calculation"><eq/>
        <ci> v_PGI </ci>
        <apply><divide/>
		  <apply><times/>
            <apply><divide/>
			  <ci> v_max </ci>
			  <ci> Km_G6P </ci>
            </apply>
			<apply><minus/>
			  <ci> G6P </ci>
              <apply><divide/>
			    <ci> F6P </ci>
				<ci> Keq_PGI </ci>
			  </apply>
            </apply>
          </apply>
          <apply><plus/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
            <apply><divide/>
              <ci> G6P </ci>
              <ci> Km_G6P </ci>
            </apply>
            <apply><divide/>
              <ci> F6P </ci>
              <ci> Km_F6P </ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="v_PGM">
    <variable cmeta:id="v_PGM_v_PGM" name="v_PGM" public_interface="out" units="flux"/>
    
    <variable initial_value="1.2" name="Km_P3G" units="millimolar"/>
    <variable initial_value="0.08" name="Km_P2G" units="millimolar"/>
    <variable initial_value="0.19" name="Keq_PGM" units="dimensionless"/>
    <variable initial_value="2525.81" name="v_max" units="flux"/>
    
    <variable name="P2G" public_interface="in" units="millimolar"/>
    <variable name="P3G" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="26">
      <apply id="v_PGM_calculation"><eq/>
        <ci> v_PGM </ci>
        <apply><divide/>
		  <apply><times/>
            <apply><divide/>
			  <ci> v_max </ci>
			  <ci> Km_P3G </ci>
            </apply>
			<apply><minus/>
			  <ci> P3G </ci>
              <apply><divide/>
			    <ci> P2G </ci>
				<ci> Keq_PGM </ci>
			  </apply>
            </apply>
          </apply>
          <apply><plus/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
            <apply><divide/>
              <ci> P3G </ci>
              <ci> Km_P3G </ci>
            </apply>
            <apply><divide/>
              <ci> P2G </ci>
              <ci> Km_P2G </ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="v_ENO">
    <variable cmeta:id="v_ENO_v_ENO" name="v_ENO" public_interface="out" units="flux"/>
    
    <variable initial_value="0.04" name="Km_P2G" units="millimolar"/>
    <variable initial_value="0.5" name="Km_PEP" units="millimolar"/>
    <variable initial_value="6.7" name="Keq_ENO" units="dimensionless"/>
    <variable initial_value="365.806" name="v_max" units="flux"/>
    
    <variable name="PEP" public_interface="in" units="millimolar"/>
    <variable name="P2G" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="27">
      <apply id="v_ENO_calculation"><eq/>
        <ci> v_ENO </ci>
        <apply><divide/>
		  <apply><times/>
            <apply><divide/>
			  <ci> v_max </ci>
			  <ci> Km_P2G </ci>
            </apply>
			<apply><minus/>
			  <ci> P2G </ci>
              <apply><divide/>
			    <ci> PEP </ci>
				<ci> Keq_ENO </ci>
			  </apply>
            </apply>
          </apply>
          <apply><plus/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
            <apply><divide/>
              <ci> P2G </ci>
              <ci> Km_P2G </ci>
            </apply>
            <apply><divide/>
              <ci> PEP </ci>
              <ci> Km_PEP </ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="v_GLK">
    <variable name="v_GLK" public_interface="out" units="flux"/>
    
    <variable initial_value="0.08" name="Km_GLCi" units="millimolar"/>
    <variable initial_value="30.0" name="Km_G6P" units="millimolar"/>
    <variable initial_value="0.15" name="Km_ATP" units="millimolar"/>
    <variable initial_value="0.23" name="Km_ADP" units="millimolar"/>
    <variable initial_value="3800" name="Keq_GLK" units="dimensionless"/>
    <variable initial_value="226.452" name="v_max" units="flux"/>
   
    <variable name="G6P" public_interface="in" units="millimolar"/>
    <variable name="GLCi" public_interface="in" units="millimolar"/>
    <variable name="ATP" public_interface="in" units="millimolar"/>
    <variable name="ADP" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="28">
      <apply id="v_GLK_calculation"><eq/>
        <ci> v_GLK </ci>
        <apply><divide/>
		  <apply><times/>
            <apply><divide/>
			  <ci> v_max </ci>
			  <apply><times/>
			    <ci> Km_GLCi </ci>
				<ci> Km_ATP </ci>
              </apply>
            </apply>
			<apply><minus/>
			  <apply><times/>
			    <ci> GLCi </ci>
				<ci> ATP </ci>
			  </apply>
              <apply><divide/>
			    <apply><times/>
			      <ci> G6P </ci>
			      <ci> ADP </ci>
			    </apply>
				<ci> Keq_GLK </ci>
		      </apply>
            </apply>
          </apply>
          <apply><times/>
		    <apply><plus/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
              <apply><divide/>
                <ci> GLCi </ci>
                <ci> Km_GLCi </ci>
              </apply>
              <apply><divide/>
                <ci> G6P </ci>
                <ci> Km_G6P </ci>
              </apply>
            </apply>
			<apply><plus/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
              <apply><divide/>
                <ci> ATP </ci>
                <ci> Km_ATP </ci>
              </apply>
              <apply><divide/>
                <ci> ADP </ci>
                <ci> Km_ADP </ci>
              </apply>
            </apply>
		  </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="v_GAPDH">
    <variable cmeta:id="v_GAPDH_v_GAPDH" name="v_GAPDH" public_interface="out" units="flux"/>
    
    <variable initial_value="0.21" name="Km_GAP" units="millimolar"/>
    <variable initial_value="0.0098" name="Km_BPG" units="millimolar"/>
    <variable initial_value="0.09" name="Km_NAD" units="millimolar"/>
    <variable initial_value="0.06" name="Km_NADH" units="millimolar"/>
    <variable initial_value="1184.52" name="v_max_f" units="flux"/>
	<variable initial_value="6549.68" name="v_max_r" units="flux"/>
    
	<variable name="Keq_TPI" public_interface="in" units="dimensionless"/>
    <variable name="BPG" public_interface="in" units="millimolar"/>
    <variable name="TRIO" public_interface="in" units="millimolar"/>
    <variable name="NAD" public_interface="in" units="millimolar"/>
    <variable name="NADH" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="29">
      <apply id="v_GAPDH_calculation"><eq/>
	    <ci> v_GAPDH </ci>
        <apply><divide/>
		  <apply><minus/>
		    <apply><divide/>
			  <apply><times/>
                <ci> v_max_f </ci>
                <apply><divide/>
  				  <ci> Keq_TPI </ci>
				  <apply><plus/>
				    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
                    <ci> Keq_TPI </ci>
                  </apply>
				</apply>
				<ci> TRIO </ci>
                <ci> NAD </ci>
              </apply>
			  <apply><times/>
			    <ci> Km_GAP </ci>
				<ci> Km_NAD </ci>
              </apply>
			</apply>
            <apply><divide/>
			  <apply><times/>
			    <ci> v_max_r </ci>
				<ci> BPG </ci>
                <ci> NADH </ci>
              </apply>
		      <apply><times/>
                <ci> Km_BPG </ci>
				<ci> Km_NADH </ci>
              </apply>
			</apply>
		  </apply>
		  <apply><times/>
	        <apply><plus/>
			  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			  <apply><divide/>
			    <apply><times/>
                  <apply><divide/>
				    <ci> Keq_TPI </ci>
					<apply><plus/>
			          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					  <ci> Keq_TPI </ci>
                    </apply>
				  </apply>
				  <ci> TRIO </ci>
                </apply>
		        <ci> Km_GAP </ci>
			  </apply>
			  <apply><divide/>
                <ci> BPG </ci>
			    <ci> Km_BPG </ci>
              </apply>
			</apply>
			<apply><plus/>
			  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>     
			  <apply><divide/>
                <ci> NAD </ci>
			    <ci> Km_NAD </ci>
              </apply>
			  <apply><divide/>
                <ci> NADH </ci>
			    <ci> Km_NADH </ci>
              </apply>
			</apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="v_PGK">
    <variable name="v_PGK" public_interface="out" units="flux"/>
    
    <variable initial_value="0.003" name="Km_BPG" units="millimolar"/>
    <variable initial_value="0.53" name="Km_P3G" units="millimolar"/>
    <variable initial_value="0.2" name="Km_ADP" units="millimolar"/>
    <variable initial_value="0.3" name="Km_ATP" units="millimolar"/>
    <variable initial_value="3200" name="Keq_PGK" units="dimensionless"/>
    <variable initial_value="1306.45" name="v_max" units="flux"/>
    
    <variable name="P3G" public_interface="in" units="millimolar"/>
    <variable name="BPG" public_interface="in" units="millimolar"/>
    <variable name="ATP" public_interface="in" units="millimolar"/>
    <variable name="ADP" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="30">
      <apply id="v_PGK_calculation"><eq/>
        <ci> v_PGK </ci>
		<apply><divide/>
		  <apply><times/>
		    <apply><divide/>
			  <ci> v_max </ci>
			  <apply><times/>
                <ci> Km_P3G </ci>
				<ci> Km_ATP </ci>
              </apply>
		    </apply>
			<apply><minus/>
		      <apply><times/>
				<ci> Keq_PGK </ci>
                <ci> BPG </ci>
				<ci> ADP </ci>
              </apply>
			  <apply><times/>
			    <ci> P3G </ci>
				<ci> ATP </ci>
              </apply>
			</apply>
		  </apply>
          <apply><times/>
			<apply><plus/>
			  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			  <apply><divide/>
                <ci> BPG </ci>
			    <ci> Km_BPG </ci>
              </apply>
			  <apply><divide/>
			    <ci> P3G </ci>
                <ci> Km_P3G </ci>
              </apply>
			</apply>
			<apply><plus/>
			  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			  <apply><divide/>
                <ci> ATP </ci>
			    <ci> Km_ATP </ci>
              </apply>
			  <apply><divide/>
			    <ci> ADP</ci>
                <ci> Km_ADP </ci>
              </apply>
			</apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>      
  
  <component name="v_PYK">
    <variable cmeta:id="v_PYK_v_PYK" name="v_PYK" public_interface="out" units="flux"/>
    
    <variable initial_value="0.14" name="Km_PEP" units="millimolar"/>
    <variable initial_value="21.0" name="Km_PYR" units="millimolar"/>
    <variable initial_value="0.53" name="Km_ADP" units="millimolar"/>
    <variable initial_value="1.5" name="Km_ATP" units="millimolar"/>
    <variable initial_value="6500" name="Keq_PYK" units="dimensionless"/>
    <variable initial_value="1088.71" name="v_max" units="flux"/>
    
    <variable name="PYR" public_interface="in" units="millimolar"/>
    <variable name="PEP" public_interface="in" units="millimolar"/>
    <variable name="ADP" public_interface="in" units="millimolar"/>
    <variable name="ATP" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="31">
       <apply id="v_PYK_calculation"><eq/>
        <ci> v_PYK </ci>
		<apply><divide/>
		  <apply><times/>
		    <apply><divide/>
			  <ci> v_max </ci>
			  <apply><times/>
                <ci> Km_PEP </ci>
				<ci> Km_ADP </ci>
              </apply>
		    </apply>
			<apply><minus/>
		      <apply><times/>
				<ci> PEP </ci>
				<ci> ADP </ci>
              </apply>
			  <apply><divide/>
			    <apply><times/>
			      <ci> PYR </ci>
				  <ci> ATP </ci>
                </apply>
				<ci> Keq_PYK </ci>
              </apply>
			</apply>
		  </apply>
          <apply><times/>
			<apply><plus/>
			  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			  <apply><divide/>
                <ci> PEP </ci>
			    <ci> Km_PEP </ci>
              </apply>
			  <apply><divide/>
			    <ci> PYR </ci>
                <ci> Km_PYR </ci>
              </apply>
			</apply>
			<apply><plus/>
			  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			  <apply><divide/>
                <ci> ATP </ci>
			    <ci> Km_ATP </ci>
              </apply>
			  <apply><divide/>
			    <ci> ADP</ci>
                <ci> Km_ADP </ci>
              </apply>
			</apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>      
  
  <component name="v_GLT">
    <variable name="v_GLT" public_interface="out" units="flux"/>
    
    <variable initial_value="1.1918" name="Km_Glco" units="millimolar"/>
    <variable initial_value="1.1918" name="Km_Glci" units="millimolar"/>
	<variable initial_value="1" name="Keq_Glc" units="dimensionless"/>
    <variable initial_value="97.264" name="v_max" units="flux"/>
    
    <variable name="GLCo" public_interface="in" units="millimolar"/>
    <variable name="GLCi" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="32">
      <apply id="v_GLT_calculation"><eq/>
	    <ci> v_GLT </ci>
        <apply><divide/>
		  <apply><times/>
            <ci> v_max </ci>
		    <apply><minus/>
			  <ci> GLCo </ci>
			  <apply><divide/>
			    <ci> GLCi </ci>
				<ci> Keq_Glc </ci>
              </apply>
		    </apply>
	      </apply>
		  <apply><times/>
            <ci> Km_Glco </ci>
			<apply><plus/>
		      <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			  <apply><divide/>
			    <ci> GLCo </ci>
				<ci> Km_Glco </ci>
			  </apply>
			  <apply><divide/>
			    <ci> GLCi </ci>
				<ci> Km_Glci </ci>
			  </apply>
			  <apply><divide/>
			    <apply><times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 0.91 </cn>
				  <ci> GLCo </ci>
				  <ci> GLCi </ci>
				</apply>
		        <apply><times/>
				  <ci> Km_Glci </ci>
				  <ci> Km_Glco </ci>
			    </apply>
		      </apply>
			</apply>
		  </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="v_ALD">
    <variable cmeta:id="v_ALD_v_ALD" name="v_ALD" public_interface="out" units="flux"/>
    
    <variable initial_value="0.3" name="Km_F16P" units="millimolar"/>
    <variable initial_value="2.0" name="Km_GAP" units="millimolar"/>
    <variable initial_value="10.0" name="Km_GAPi" units="millimolar"/>
    <variable initial_value="2.4" name="Km_DHAP" units="millimolar"/>
    <variable initial_value="0.069" name="Keq_ALD" units="millimolar"/>
    <variable initial_value="322.258" name="v_max" units="flux"/>
    
	<variable name="Keq_TPI" public_interface="in" units="dimensionless"/>
    <variable name="TRIO" public_interface="in" units="millimolar"/>
    <variable name="F16P" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="33">
      <apply><eq/>
        <ci> v_ALD </ci>
        <apply><divide/>
		  <apply><times/>
            <apply><divide/>
			  <ci> v_max </ci>
			  <ci> Km_F16P </ci>
			</apply>
			<apply><minus/>
			  <ci> F16P </ci>
              <apply><divide/>
                <apply><times/>
				  <apply><divide/>
				    <ci> Keq_TPI </ci>
					<apply><plus/>
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					  <ci> Keq_TPI </ci>
					</apply>
				  </apply>
				  <ci> TRIO </ci>
				  <apply><divide/>
				    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					<apply><plus/>
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					  <ci> Keq_TPI </ci>
					</apply>
				  </apply>
				  <ci> TRIO </ci>
				</apply>
				<ci> Keq_ALD </ci>
		      </apply>
		    </apply>
		  </apply>
		  <apply><plus/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>	
            <apply><divide/>
              <ci> F16P </ci>
              <ci> Km_F16P </ci>
            </apply>
            <apply><divide/>
			  <apply><times/>
			    <apply><divide/>
				  <ci> Keq_TPI </ci>
				  <apply><plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					<ci> Keq_TPI </ci>
			      </apply>
				</apply>
				<ci> TRIO </ci>
              </apply>
			  <ci> Km_GAP </ci>
			</apply>
			<apply><divide/>
			  <apply><times/>
			    <apply><divide/>
				  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			      <apply><plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					<ci> Keq_TPI </ci>
			      </apply>
				</apply>
				<ci> TRIO </ci>
              </apply>
			  <ci> Km_DHAP </ci>
			</apply>
			<apply><divide/>
			  <apply><times/>
			    <apply><divide/>
				  <ci> Keq_TPI </ci>
				  <apply><plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					<ci> Keq_TPI </ci>
			      </apply>
				</apply>
				<ci> TRIO </ci>
				<apply><divide/>
				  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			      <apply><plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					<ci> Keq_TPI </ci>
			      </apply>
				</apply>
				<ci> TRIO </ci>
              </apply>
			  <apply><times/>
			    <ci> Km_GAP </ci>
                <ci> Km_DHAP </ci>
			  </apply>
			</apply>
			<apply><divide/>
			  <apply><times/>
                <ci> F16P </ci>
                <apply><divide/>
				  <ci> Keq_TPI </ci>
				  <apply><plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					<ci> Keq_TPI </ci>
			      </apply>
				</apply>
				<ci> TRIO </ci>				
			  </apply>
              <apply><times/>
                <ci> Km_GAPi </ci>
				<ci> Km_F16P </ci>
			  </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="v_PDC">
    <variable cmeta:id="v_PDC_v_PDC" name="v_PDC" public_interface="out" units="flux"/>
    
    <variable initial_value="1.9" name="nPDC" units="dimensionless"/>
    <variable initial_value="4.33" name="Km_PYR" units="millimolar"/>
    <variable initial_value="174.194" name="v_max" units="flux"/>
    
    <variable name="PYR" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="34">
      <apply><eq/>
        <ci> v_PDC </ci>
        <apply><divide/>
		  <apply><times/>
            <ci> v_max </ci>
			<apply><divide/>
			  <apply><power/>
			    <ci> PYR </ci>
				<ci> nPDC </ci>
              </apply>
			  <apply><power/>
                <ci> Km_PYR </ci>
                <ci> nPDC </ci>
              </apply>
            </apply>
          </apply>
		  <apply><plus/>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			<apply><divide/>
			  <apply><power/>
			    <ci> PYR </ci>
				<ci> nPDC </ci>
              </apply>
			  <apply><power/>
                <ci> Km_PYR </ci>
                <ci> nPDC </ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="v_ADH">
    <variable cmeta:id="v_ADH_v_ADH" name="v_ADH" public_interface="out" units="flux"/>
    
    <variable initial_value="0.17" name="Km_NAD" units="millimolar"/>
    <variable initial_value="0.11" name="Km_NADH" units="millimolar"/>
    <variable initial_value="1.11" name="Km_ACE" units="millimolar"/>
    <variable initial_value="17.0" name="Km_ETOH" units="millimolar"/>
    <variable initial_value="0.031" name="Ki_NADH" units="millimolar"/>
	<variable initial_value="0.92" name="Ki_NAD" units="millimolar"/>
    <variable initial_value="1.1" name="Ki_ACE" units="millimolar"/>
    <variable initial_value="90.0" name="Ki_ETOH" units="millimolar"/>
    <variable initial_value="810.0" name="v_max" units="flux"/>
	<variable initial_value="0.000069" name="Keq_ADH" units="dimensionless"/>
    
    <variable name="ETOH" public_interface="in" units="millimolar"/>
    <variable name="ACE" public_interface="in" units="millimolar"/>
    <variable name="NADH" public_interface="in" units="millimolar"/>
    <variable name="NAD" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="35">
      <apply id="v_ADH_calculation"><eq/>
	    <ci> v_ADH </ci>
        <apply><minus/>
		  <apply><times/>
		    <apply><divide/>
			  <ci> v_max </ci>
			  <apply><times/>
                <ci> Ki_NAD </ci>
                <ci> Km_ETOH </ci>
              </apply>
			</apply>
			<apply><divide/>
		      <apply><minus/>
			    <apply><times/>
                  <ci> NAD </ci>
                  <ci> ETOH </ci>
                </apply>
		        <apply><divide/>
			      <apply><times/>
                    <ci> NADH </ci>
				    <ci> ACE </ci>
                  </apply>
				  <ci> Keq_ADH </ci>
				</apply>
			  </apply>
			  <apply><plus/>
				<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
			    <apply><divide/>
                  <ci> NAD </ci>
			      <ci> Ki_NAD </ci>
                </apply>
			    <apply><divide/>
			      <apply><times/>
                    <ci> Km_NAD </ci>
				    <ci> ETOH </ci>
				  </apply>
				  <apply><times/>
                    <ci> Ki_NAD </ci>
				    <ci> Km_ETOH </ci>
				  </apply>
				</apply>
				<apply><divide/>
			      <apply><times/>
                    <ci> Km_NADH </ci>
				    <ci> ACE </ci>
				  </apply>
				  <apply><times/>
                    <ci> Ki_NADH </ci>
				    <ci> Km_ACE </ci>
				  </apply>
				</apply>
				<apply><divide/>
                  <ci> NADH </ci>
			      <ci> Ki_NADH </ci>
                </apply>
				<apply><divide/>
			      <apply><times/>
                    <ci> NAD </ci>
				    <ci> ETOH </ci>
				  </apply>
				  <apply><times/>
                    <ci> Ki_NAD </ci>
				    <ci> Km_ETOH </ci>
				  </apply>
				</apply>
				<apply><divide/>
			      <apply><times/>
                    <ci> Km_NADH </ci>
					<ci> NAD </ci>
				    <ci> ACE </ci>
				  </apply>
				  <apply><times/>
				    <ci> Ki_NAD </ci>
                    <ci> Ki_NADH </ci>
				    <ci> Km_ACE </ci>
				  </apply>
				</apply>
				<apply><divide/>
			      <apply><times/>
                    <ci> Km_NAD </ci>
					<ci> ETOH </ci>
				    <ci> NADH </ci>
				  </apply>
				  <apply><times/>
				    <ci> Ki_NAD </ci>
                    <ci> Km_ETOH</ci>
				    <ci> Ki_NADH </ci>
				  </apply>
				</apply>
				<apply><divide/>
			      <apply><times/>
                    <ci> NADH </ci>
					<ci> ACE </ci>
				  </apply>
				  <apply><times/>
				    <ci> Ki_NADH </ci>
				    <ci> Km_ACE </ci>
				  </apply>
				</apply>
				<apply><divide/>
			      <apply><times/>
                    <ci> NAD </ci>
					<ci> ETOH </ci>
				    <ci> ACE </ci>
				  </apply>
				  <apply><times/>
				    <ci> Ki_NAD </ci>
                    <ci> Km_ETOH </ci>
				    <ci> Ki_ACE </ci>
				  </apply>
				</apply>
				<apply><divide/>
			      <apply><times/>
                    <ci> ETOH </ci>
					<ci> NADH </ci>
				    <ci> ACE </ci>
				  </apply>
				  <apply><times/>
				    <ci> Ki_ETOH </ci>
                    <ci> Ki_NADH </ci>
				    <ci> Km_ACE </ci>
				  </apply>
				</apply>
			  </apply>
			</apply>
		  </apply>
        </apply>
      </apply>
    </math>
  </component>     
 
  <component name="v_ATP">
    <variable name="v_ATP" public_interface="out" units="flux"/>
    
    <variable initial_value="33.7" name="Km_ATPase" units="first_order_rate_constant"/>
    
    <variable name="ATP" public_interface="in" units="millimolar"/> 
     
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="36">
      <apply>
        <eq/>
        <ci> v_ATP </ci>
        <apply>
          <times/>
          <ci> Km_ATPase </ci>
          <ci> ATP </ci>
        </apply>
      </apply> 
    </math>
  </component>
  
  <component name="v_PFK">
    <variable name="v_PFK" public_interface="out" units="flux"/>
    
    <variable initial_value="182.903" name="v_max" units="flux"/>
	<variable initial_value="5.12" name="gR" units="dimensionless"/>
	<variable initial_value="0.66" name="L0" units="per_millimolar2"/>
	<variable initial_value="0.1" name="Km_F6P" units="millimolar"/>
	<variable initial_value="0.71" name="Km_ATP" units="millimolar"/>
	<variable initial_value="3.0" name="CATP" units="millimolar"/>
	<variable initial_value="0.0995" name="Km_AMP" units="millimolar"/>
	<variable initial_value="0.0845" name="CAMP" units="dimensionless"/>
	<variable initial_value="0.65" name="Ki_ATP" units="millimolar"/>
	<variable initial_value="100.0" name="Ci_ATP" units="dimensionless"/>
	<variable initial_value="0.000682" name="Km_F26BP" units="millimolar"/>
	<variable initial_value="0.0174" name="CF26BP" units="dimensionless"/>
	<variable initial_value="0.111" name="Km_F16BP" units="millimolar"/>
	<variable initial_value="0.397" name="CF16BP" units="dimensionless"/>
	<variable name="L" units="per_millimolar2"/>
    <variable name="R" units="dimensionless"/>
    <variable name="T" units="millimolar"/>
    
    <variable name="F6P" public_interface="in" units="millimolar"/>
    <variable name="F16P" public_interface="in" units="millimolar"/>
    <variable name="F26P" public_interface="in" units="millimolar"/>
    <variable name="ATP" public_interface="in" units="millimolar"/>
    <variable name="AMP" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="37">
      <apply id="v_PFKm_calculation"><eq/>
	    <ci> v_PFK </ci>
        <apply><times/>
		  <ci> v_max </ci>
		  <ci> gR </ci>
		  <apply><divide/>
			<ci> F6P </ci>
		    <ci> Km_F6P </ci>
          </apply>
		  <apply><divide/>
			<ci> ATP </ci>
		    <ci> Km_ATP </ci>
          </apply>
	      <apply><divide/>
		    <ci> R </ci>
            <apply><plus/>
			  <apply><power/>
                <ci> R </ci>
				<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2 </cn>
			  </apply>
			  <apply><times/>
                <ci> L </ci>
				<apply><power/>
                  <ci> T </ci>
				  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2 </cn>
			    </apply>
			  </apply>    
			</apply>
		  </apply>
        </apply>
      </apply>
    </math>
  
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="38"> 
      <apply id="R_calculation"><eq/>
        <ci> R </ci>
        <apply><plus/>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
		  <apply><divide/>
            <ci> F6P </ci>
            <ci> Km_F6P </ci>
          </apply>
		  <apply><divide/>
            <ci> ATP </ci>
            <ci> Km_ATP </ci>
          </apply>
          <apply><times/>
            <ci> gR </ci>
            <apply><divide/>
              <ci> F6P </ci>
              <ci> Km_F6P </ci>
            </apply>
		    <apply><divide/>
              <ci> ATP </ci>
              <ci> Km_ATP </ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="39">  
      <apply id="L_calculation"><eq/>
        <ci> L </ci>
        <apply><times/>
          <ci> L0 </ci>
          <apply><power/>
            <apply><divide/>
              <apply><plus/>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
                <apply><times/>
                  <ci> Ci_ATP </ci>
				  <apply><divide/>
                    <ci> ATP </ci>
                    <ci> Ki_ATP </ci>
                  </apply>
                </apply>
			  </apply>
              <apply><plus/>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
                <apply><divide/>
                  <ci> ATP </ci>
                  <ci> Ki_ATP </ci>
                </apply>
              </apply>
            </apply>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
          </apply>
          <apply><power/>
            <apply><divide/>
              <apply><plus/>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
                <apply><times/>
                  <ci> CAMP </ci>
				  <apply><divide/>
                    <ci> AMP </ci>
                    <ci> Km_AMP </ci>
				  </apply>
                </apply>
              </apply>
              <apply><plus/>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
                <apply><divide/>
                  <ci> AMP </ci>
                  <ci> Km_AMP </ci>
                </apply>
              </apply>
            </apply>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2.0 </cn>
          </apply>
		  <apply><power/>
            <apply><divide/>
              <apply><plus/>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
                <apply><times/>
                  <ci> CF26BP </ci>
				  <apply><divide/>
                    <ci> F26P </ci>
                    <ci> Km_F26BP </ci>
                  </apply>
				</apply>
				<apply><times/>
                  <ci> CF16BP </ci>
				  <apply><divide/>
                    <ci> F16P </ci>
                    <ci> Km_F16BP </ci>
                  </apply>
				</apply>
			  </apply>
			  <apply><plus/>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
				<apply><divide/>
                  <ci> F26P </ci>
                  <ci> Km_F26BP </ci>
                </apply>
				<apply><divide/>
                  <ci> F16P </ci>
                  <ci> Km_F16BP </ci>
                </apply>
              </apply>
            </apply>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 2 </cn>
          </apply>
        </apply>
      </apply> 
    </math>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="40"> 
       <apply id="T_calculation"><eq/>
        <ci> T </ci>
        <apply><plus/>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar"> 1.0 </cn>
          <apply><times/>
            <ci> CATP </ci>
            <apply><divide/>
              <ci> ATP </ci>
              <ci> Km_ATP </ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math> 
  </component>
  
  <!--
    The following components describe the reactions of the branches introduced in the extended model.  For simplicity, fluxes to glycogen and trehalose are introduced as experimentally derived constants.
  -->
  
  <component name="v_G3PDH">
    <variable cmeta:id="v_G3PDH_v_G3PDH" name="v_G3PDH" public_interface="out" units="flux"/>
    
    <variable initial_value="0.4" name="Km_DHAP" units="millimolar"/>
    <variable initial_value="1" name="Km_GLY" units="millimolar"/>
    <variable initial_value="0.023" name="Km_NADH" units="millimolar"/>
    <variable initial_value="0.93" name="Km_NAD" units="millimolar"/>
    <variable initial_value="4300" name="Keq_G3PDH" units="dimensionless"/>
    <variable initial_value="70.15" name="v_max" units="flux"/>
    
    <variable name="Keq_TPI" public_interface="in" units="dimensionless"/>
	<variable name="TRIO" public_interface="in" units="millimolar"/>
    <variable name="GLY" public_interface="in" units="millimolar"/>
    <variable name="NADH" public_interface="in" units="millimolar"/>
    <variable name="NAD" public_interface="in" units="millimolar"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="43">
      <apply><eq/>
        <ci>v_G3PDH</ci>
        <apply><divide/>
		  <apply><times/>
            <apply><divide/>
			  <ci> v_max </ci>
			  <apply><times/>
                <ci> Km_DHAP </ci>
			    <ci> Km_NADH </ci>
		      </apply>
			</apply>
			<apply><minus/>
              <apply><times/>
			    <apply><divide/>
				  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
				  <apply><plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
				    <ci> Keq_TPI </ci>
                  </apply>
				</apply>
				<ci> TRIO </ci>
                <ci> NADH </ci>
              </apply>
			  <apply><divide/>
                <apply><times/>
                  <ci> GLY </ci>
                  <ci> NAD </ci>
                </apply>
				<ci> Keq_G3PDH </ci>
              </apply>
			</apply>
          </apply>
		  <apply><times/>
            <apply><plus/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
              <apply><divide/>
			    <apply><times/>
			      <apply><divide/>
				    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
				    <apply><plus/>
                      <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
					  <ci> Keq_TPI </ci>
			        </apply>
				  </apply>
				  <ci> TRIO </ci>
			    </apply>
				<ci> Km_DHAP </ci>
              </apply>
			  <apply><divide/>
                <ci> GLY </ci>
                <ci> Km_GLY </ci>
              </apply>
			</apply>
            <apply><plus/>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless"> 1.0 </cn>
              <apply><divide/>
                <ci> NADH </ci>
                <ci> Km_NADH </ci>
              </apply>
			  <apply><divide/>
                <ci> NAD </ci>
                <ci> Km_NAD </ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>

  <component name="v_succinate">
    <variable cmeta:id="v_succinate_v_succinate" name="v_succinate" public_interface="out" units="flux"/>
    
    <variable initial_value="21.4" name="Km_succinate" units="first_order_rate_constant"/>
    
    <variable name="ACE" public_interface="in" units="millimolar"/> 
    
    <math xmlns="http://www.w3.org/1998/Math/MathML" id="44">
      <apply>
        <eq/>
        <ci>v_succinate</ci>
        <apply>
          <times/>
          <ci> Km_succinate </ci>
          <ci> ACE </ci>
        </apply>
      </apply> 
    </math>
  </component>

  <component name="v_glycogen">
    <variable cmeta:id="v_glycogen_v_glycogen" initial_value="6.0" name="v_glycogen" public_interface="out" units="flux"/>
  </component>

  <component name="v_trehalose">
    <variable cmeta:id="v_trehalose_v_trehalose" initial_value="2.4" name="v_trehalose" public_interface="out" units="flux"/>
  </component>

  
  <!-- Connections -->
  
  <connection>
    <map_components component_1="GLCi" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="G6P" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="F6P" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="F16P" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="TRIO" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>

  <connection>
    <map_components component_1="BPG" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="P3G" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="P2G" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="PEP" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>

  <connection>
    <map_components component_1="PYR" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="ACE" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>

  <connection>
    <map_components component_1="P" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="NADH" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="NAD" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="GLCo" component_2="v_GLT"/>
    <map_variables variable_1="GLCo" variable_2="GLCo"/>
  </connection>
  
  <connection>
    <map_components component_1="GLCi" component_2="v_GLT"/>
    <map_variables variable_1="GLCi" variable_2="GLCi"/>
    <map_variables variable_1="v_GLT" variable_2="v_GLT"/>
  </connection>
  
  <connection>
    <map_components component_1="GLCi" component_2="v_GLK"/>
    <map_variables variable_1="GLCi" variable_2="GLCi"/>
    <map_variables variable_1="v_GLK" variable_2="v_GLK"/>
  </connection>
  
  <connection>
    <map_components component_1="G6P" component_2="v_GLK"/>
    <map_variables variable_1="G6P" variable_2="G6P"/>
    <map_variables variable_1="v_GLK" variable_2="v_GLK"/>
  </connection>
  
  <connection>
    <map_components component_1="G6P" component_2="v_PGI"/>
    <map_variables variable_1="G6P" variable_2="G6P"/>
    <map_variables variable_1="v_PGI" variable_2="v_PGI"/>
  </connection>
  
  <connection>
    <map_components component_1="G6P" component_2="v_trehalose"/>
    <map_variables variable_1="v_trehalose" variable_2="v_trehalose"/>
  </connection>
  
  <connection>
    <map_components component_1="G6P" component_2="v_glycogen"/>
    <map_variables variable_1="v_glycogen" variable_2="v_glycogen"/>
  </connection>
  
  <connection>
    <map_components component_1="F6P" component_2="v_PGI"/>
    <map_variables variable_1="F6P" variable_2="F6P"/>
    <map_variables variable_1="v_PGI" variable_2="v_PGI"/>
  </connection>
  
  <connection>
    <map_components component_1="F6P" component_2="v_PFK"/>
    <map_variables variable_1="F6P" variable_2="F6P"/>
    <map_variables variable_1="v_PFK" variable_2="v_PFK"/>
  </connection>
  
  <connection>
    <map_components component_1="F16P" component_2="v_PFK"/>
    <map_variables variable_1="F16P" variable_2="F16P"/>
    <map_variables variable_1="v_PFK" variable_2="v_PFK"/>
  </connection>
  
  <connection>
    <map_components component_1="F16P" component_2="v_ALD"/>
    <map_variables variable_1="F16P" variable_2="F16P"/>
    <map_variables variable_1="v_ALD" variable_2="v_ALD"/>
  </connection>

  <connection>
    <map_components component_1="F26P" component_2="v_PFK"/>
    <map_variables variable_1="F26P" variable_2="F26P"/>
  </connection>

  <connection>
    <map_components component_1="TRIO" component_2="v_ALD"/>
    <map_variables variable_1="v_ALD" variable_2="v_ALD"/>
	<map_variables variable_1="TRIO" variable_2="TRIO"/>
  </connection>

  <connection>
    <map_components component_1="TRIO" component_2="v_GAPDH"/>
    <map_variables variable_1="v_GAPDH" variable_2="v_GAPDH"/>
	<map_variables variable_1="TRIO" variable_2="TRIO"/>
  </connection>

  <connection>
    <map_components component_1="TRIO" component_2="v_G3PDH"/>
    <map_variables variable_1="v_G3PDH" variable_2="v_G3PDH"/>
	<map_variables variable_1="TRIO" variable_2="TRIO"/>
  </connection>

  <connection>
    <map_components component_1="BPG" component_2="v_GAPDH"/>
    <map_variables variable_1="BPG" variable_2="BPG"/>
    <map_variables variable_1="v_GAPDH" variable_2="v_GAPDH"/>
  </connection>

  <connection>
    <map_components component_1="BPG" component_2="v_PGK"/>
    <map_variables variable_1="BPG" variable_2="BPG"/>
    <map_variables variable_1="v_PGK" variable_2="v_PGK"/>
  </connection>

  <connection>
    <map_components component_1="P3G" component_2="v_PGK"/>
    <map_variables variable_1="P3G" variable_2="P3G"/>
    <map_variables variable_1="v_PGK" variable_2="v_PGK"/>
  </connection>
  
  <connection>
    <map_components component_1="P3G" component_2="v_PGM"/>
    <map_variables variable_1="P3G" variable_2="P3G"/>
    <map_variables variable_1="v_PGM" variable_2="v_PGM"/>
  </connection>
  
  <connection>
    <map_components component_1="P2G" component_2="v_PGM"/>
    <map_variables variable_1="P2G" variable_2="P2G"/>
    <map_variables variable_1="v_PGM" variable_2="v_PGM"/>
  </connection>
  
  <connection>
    <map_components component_1="P2G" component_2="v_ENO"/>
    <map_variables variable_1="P2G" variable_2="P2G"/>
    <map_variables variable_1="v_ENO" variable_2="v_ENO"/>
  </connection>
  
  <connection>
    <map_components component_1="PEP" component_2="v_ENO"/>
    <map_variables variable_1="PEP" variable_2="PEP"/>
    <map_variables variable_1="v_ENO" variable_2="v_ENO"/>
  </connection>
  
  <connection>
    <map_components component_1="PEP" component_2="v_PYK"/>
    <map_variables variable_1="PEP" variable_2="PEP"/>
    <map_variables variable_1="v_PYK" variable_2="v_PYK"/>
  </connection>
  
  <connection>
    <map_components component_1="PYR" component_2="v_PYK"/>
    <map_variables variable_1="PYR" variable_2="PYR"/>
    <map_variables variable_1="v_PYK" variable_2="v_PYK"/>
  </connection>
  
  <connection>
    <map_components component_1="PYR" component_2="v_PDC"/>
    <map_variables variable_1="PYR" variable_2="PYR"/>
    <map_variables variable_1="v_PDC" variable_2="v_PDC"/>
  </connection>
  
  <connection>
    <map_components component_1="ACE" component_2="v_PDC"/>
    <map_variables variable_1="v_PDC" variable_2="v_PDC"/>
  </connection>
  
  <connection>
    <map_components component_1="ACE" component_2="v_ADH"/>
    <map_variables variable_1="ACE" variable_2="ACE"/>
    <map_variables variable_1="v_ADH" variable_2="v_ADH"/>
  </connection>
  
  <connection>
    <map_components component_1="ACE" component_2="v_succinate"/>
    <map_variables variable_1="ACE" variable_2="ACE"/>
    <map_variables variable_1="v_succinate" variable_2="v_succinate"/>
  </connection>
  
  <connection>
    <map_components component_1="P" component_2="v_GLK"/>
    <map_variables variable_1="v_GLK" variable_2="v_GLK"/>
  </connection>

  <connection>
    <map_components component_1="P" component_2="v_PFK"/>
    <map_variables variable_1="v_PFK" variable_2="v_PFK"/>
  </connection>

  <connection>
    <map_components component_1="P" component_2="v_PGK"/>
    <map_variables variable_1="v_PGK" variable_2="v_PGK"/>
  </connection>

  <connection>
    <map_components component_1="P" component_2="v_PYK"/>
    <map_variables variable_1="v_PYK" variable_2="v_PYK"/>
  </connection>

  <connection>
    <map_components component_1="P" component_2="v_ATP"/>
    <map_variables variable_1="v_ATP" variable_2="v_ATP"/>
  </connection>

  <connection>
    <map_components component_1="P" component_2="v_trehalose"/>
    <map_variables variable_1="v_trehalose" variable_2="v_trehalose"/>
  </connection>

  <connection>
    <map_components component_1="P" component_2="v_glycogen"/>
    <map_variables variable_1="v_glycogen" variable_2="v_glycogen"/>
  </connection>

  <connection>
    <map_components component_1="P" component_2="v_succinate"/>
    <map_variables variable_1="v_succinate" variable_2="v_succinate"/>
  </connection> 
  
  <connection>
    <map_components component_1="ATP" component_2="v_GLK"/>
    <map_variables variable_1="ATP" variable_2="ATP"/>
  </connection>

  <connection>
    <map_components component_1="ATP" component_2="v_PGK"/>
    <map_variables variable_1="ATP" variable_2="ATP"/>
  </connection>

  <connection>
    <map_components component_1="ATP" component_2="v_PYK"/>
    <map_variables variable_1="ATP" variable_2="ATP"/>
  </connection>

  <connection>
    <map_components component_1="ATP" component_2="v_PFK"/>
    <map_variables variable_1="ATP" variable_2="ATP"/>
  </connection>

  <connection>
    <map_components component_1="ATP" component_2="v_ATP"/>
    <map_variables variable_1="ATP" variable_2="ATP"/>
  </connection>

  <connection>
    <map_components component_1="ADP" component_2="P"/>
    <map_variables variable_1="P" variable_2="P"/>
  </connection>

  <connection>
    <map_components component_1="ATP" component_2="ADP"/>
    <map_variables variable_1="ADP" variable_2="ADP"/>
  </connection>
  
  <connection>
    <map_components component_1="ATP" component_2="P"/>
    <map_variables variable_1="P" variable_2="P"/>
  </connection>
  
  <connection>
    <map_components component_1="ATP" component_2="AMP"/>
    <map_variables variable_1="ATP" variable_2="ATP"/>
  </connection>
  
  <connection>
    <map_components component_1="ADP" component_2="AMP"/>
    <map_variables variable_1="ADP" variable_2="ADP"/>
	<map_variables variable_1="SUM_P" variable_2="SUM_P"/>
  </connection> 

  <connection>
    <map_components component_1="ADP" component_2="v_GLK"/>
    <map_variables variable_1="ADP" variable_2="ADP"/>
  </connection>

  <connection>
    <map_components component_1="ADP" component_2="v_PGK"/>
    <map_variables variable_1="ADP" variable_2="ADP"/>
  </connection>

  <connection>
    <map_components component_1="ADP" component_2="v_PYK"/>
    <map_variables variable_1="ADP" variable_2="ADP"/>
  </connection>

  <connection>
    <map_components component_1="AMP" component_2="v_PFK"/>
    <map_variables variable_1="AMP" variable_2="AMP"/>
  </connection>
  
  <connection>
    <map_components component_1="NADH" component_2="v_GAPDH"/>
    <map_variables variable_1="NADH" variable_2="NADH"/>
    <map_variables variable_1="v_GAPDH" variable_2="v_GAPDH"/>
  </connection>
  
  <connection>
    <map_components component_1="NADH" component_2="v_ADH"/>
    <map_variables variable_1="NADH" variable_2="NADH"/>
    <map_variables variable_1="v_ADH" variable_2="v_ADH"/>
  </connection>
  
  <connection>
    <map_components component_1="NADH" component_2="v_G3PDH"/>
    <map_variables variable_1="NADH" variable_2="NADH"/>
    <map_variables variable_1="v_G3PDH" variable_2="v_G3PDH"/>
  </connection>
  
  <connection>
    <map_components component_1="NADH" component_2="v_succinate"/>
    <map_variables variable_1="v_succinate" variable_2="v_succinate"/>
  </connection>
  
  <connection>
    <map_components component_1="NAD" component_2="v_GAPDH"/>
    <map_variables variable_1="NAD" variable_2="NAD"/>
    <map_variables variable_1="v_GAPDH" variable_2="v_GAPDH"/>
  </connection>
  
  <connection>
    <map_components component_1="NAD" component_2="v_ADH"/>
    <map_variables variable_1="NAD" variable_2="NAD"/>
    <map_variables variable_1="v_ADH" variable_2="v_ADH"/>
  </connection>
  
  <connection>
    <map_components component_1="NAD" component_2="v_G3PDH"/>
    <map_variables variable_1="NAD" variable_2="NAD"/>
    <map_variables variable_1="v_G3PDH" variable_2="v_G3PDH"/>
  </connection>
  
  <connection>
    <map_components component_1="NAD" component_2="v_succinate"/>
    <map_variables variable_1="v_succinate" variable_2="v_succinate"/>
  </connection>
  
  <connection>
    <map_components component_1="DHAP" component_2="TRIO"/>
    <map_variables variable_1="TRIO" variable_2="TRIO"/>
  </connection>

  <connection>
    <map_components component_1="GAP" component_2="TRIO"/>
    <map_variables variable_1="TRIO" variable_2="TRIO"/>
  </connection>
  
  <connection>
    <map_components component_1="DHAP" component_2="GAP"/>
    <map_variables variable_1="Keq_TPI" variable_2="Keq_TPI"/>
  </connection>
  
  <connection>
    <map_components component_1="DHAP" component_2="v_GAPDH"/>
    <map_variables variable_1="Keq_TPI" variable_2="Keq_TPI"/>
  </connection>

  <connection>
    <map_components component_1="DHAP" component_2="v_ALD"/>
    <map_variables variable_1="Keq_TPI" variable_2="Keq_TPI"/>
  </connection>

  <connection>
    <map_components component_1="DHAP" component_2="v_G3PDH"/>
    <map_variables variable_1="Keq_TPI" variable_2="Keq_TPI"/>
  </connection>
  
  <connection>
    <map_components component_1="GLY" component_2="v_G3PDH"/>
    <map_variables variable_1="GLY" variable_2="GLY"/>
  </connection>
  
  <connection>
    <map_components component_1="ETOH" component_2="v_ADH"/>
    <map_variables variable_1="ETOH" variable_2="ETOH"/>
  </connection>
  
  



<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#d5eaa377-be4d-4a11-8da5-7d505808dbcf"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="#P2G"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">P2G</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">2-phosphoglycerate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#d2c2ce2d-b326-445f-a320-64ca5865abd0"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine Lloyd</FN></rdf:Description><rdf:Description rdf:about="rdf:#b1c84d02-295a-45a6-b953-4e2f14f7c839"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#f504b049-7264-462c-b536-62d798d2adec"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="#BPG"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">BPG</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">1,3-bisphosphoglycerate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#f504b049-7264-462c-b536-62d798d2adec"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Schepper</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Mike</Given></rdf:Description><rdf:Description rdf:about="#NADH"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">NADH</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">
          nicotinamide adenine dinucleotide
        </alternative></rdf:Description><rdf:Description rdf:about="#GLY"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">GLY</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">glycerol</alternative></rdf:Description><rdf:Description rdf:about="rdf:#2142b85e-67d3-40d7-99c2-b0dca527aa8a"><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The University of Auckland</Orgname><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Auckland Bioengineering Institute</Orgunit></rdf:Description><rdf:Description rdf:nodeID="n1"><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest><rdf:first><rdf:Description rdf:nodeID="n2"/></rdf:first></rdf:Description><rdf:Description rdf:about="rdf:#20a9d771-69dc-43a1-b8e1-b05cde073dd6"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine Lloyd</FN></rdf:Description><rdf:Description rdf:about="#P3G"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">P3G</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">3-phosphoglycerate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#d311aaa8-028c-4be3-ba61-235adb69a4e1"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#22ee34b6-b6ff-4d01-8424-d62e31619370"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#fc960cc1-1cbc-4493-a793-082fd0b394ec"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">van Dam</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Karel</Given></rdf:Description><rdf:Description rdf:about="rdf:#74ec10e4-5e4a-4564-9d38-7c38fde05e73"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#efa52486-96bd-4aa6-bee9-a98e562e3c58"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about=""><cmeta:comment><rdf:Description rdf:about="rdf:#04464991-7d2b-4d2e-ad72-dfab3534c53e"/></cmeta:comment><created xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#83c688ba-7501-4326-b311-4705b419fcde"/></created><cmeta:modification><rdf:Description rdf:about="rdf:#adcfb7be-3d40-4245-ab04-1129791790bb"/></cmeta:modification><publisher xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Auckland Bioengineering Institute, The University of Auckland</publisher><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#24b20a93-7e2b-4c6c-ad6a-bb78a61c46db"/></creator></rdf:Description><rdf:Description rdf:about="rdf:#adcfb7be-3d40-4245-ab04-1129791790bb"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#6267383c-a96b-4b12-b7dd-e25f67a9f193"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#c9da28fd-2f47-42ad-83a9-e644a54235d6"/></cmeta:modifier><rdf:value xml:lang="en">Recoded the model to remove the reaction element.</rdf:value></rdf:Description><rdf:Description rdf:about="#GAP"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">GAP</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">D-glyceraldehyde-3-phosphate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#6267383c-a96b-4b12-b7dd-e25f67a9f193"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2008-01-07T07:39:20+13:00</W3CDTF></rdf:Description><rdf:Description rdf:about="#PEP"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">PEP</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">phosphoenolpyruvate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#5ff25bc5-cf6a-4cd1-bb0d-717b4fedd713"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#c10e8244-a771-4ef8-9144-30886a49827b"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="#G6P"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">G6P</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">glucose 6-phosphate</alternative></rdf:Description><rdf:Description rdf:about="#teusink_model_2000"><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n3"/></simulation><cmeta:species xml:lang="en">Saccharomyces cerevisae</cmeta:species><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#37bb0719-50cb-49df-b336-ef58837e22c7"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#5a2b126b-b39b-4d8a-a502-95d15df4960a"/></reference><cmeta:comment><rdf:Description rdf:about="rdf:#9ac628eb-ef88-4250-b113-c81de8e9ed90"/></cmeta:comment><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">
        Teusink et al.'s 2000 model for glycolysis in yeast.
      </title></rdf:Description><rdf:Description rdf:about="rdf:#173c8ac6-5251-41c2-b777-e75984be5795"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#8013d42f-a14e-4c49-a784-3f5cee467ddc"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="#ADP"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">ADP</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">adenosine diphoshate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#8256b0d9-6646-46e2-925a-64c69cf55ef8"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Esgalhado</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Eugenia</Given></rdf:Description><rdf:Description rdf:about="rdf:#9ac628eb-ef88-4250-b113-c81de8e9ed90"><rdf:value xml:lang="en">This is the CellML description of Teusink et al.'s 2000 model for glycolysis in yeast.</rdf:value><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#20a9d771-69dc-43a1-b8e1-b05cde073dd6"/></creator></rdf:Description><rdf:Description rdf:about="#NAD"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">NAD</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">
          charged nicotinamide adenine dinucleotide
        </alternative></rdf:Description><rdf:Description rdf:about="#ACE"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">ACE</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">acetaldehyde</alternative></rdf:Description><rdf:Description rdf:about="rdf:#a1534d7c-b9da-4708-9c2d-7d5abbdc42c7"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#5a7f4dda-a178-49d9-9078-28a8dd43c40b"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#2a66967d-8b92-4318-992b-e4043c06980e"><rdf:_3><rdf:Description rdf:about="rdf:#fb1a7687-6b95-44bf-804f-ce6a564a8829"/></rdf:_3><rdf:_1><rdf:Description rdf:about="rdf:#a1534d7c-b9da-4708-9c2d-7d5abbdc42c7"/></rdf:_1><rdf:_4><rdf:Description rdf:about="rdf:#fc866882-356e-47b7-89c8-692f4dc602d2"/></rdf:_4><rdf:_2><rdf:Description rdf:about="rdf:#74ec10e4-5e4a-4564-9d38-7c38fde05e73"/></rdf:_2><rdf:_6><rdf:Description rdf:about="rdf:#b1c84d02-295a-45a6-b953-4e2f14f7c839"/></rdf:_6><rdf:_9><rdf:Description rdf:about="rdf:#411b37f6-c890-4c61-a78a-858ed9b7d098"/></rdf:_9><rdf:_5><rdf:Description rdf:about="rdf:#d311aaa8-028c-4be3-ba61-235adb69a4e1"/></rdf:_5><rdf:_8><rdf:Description rdf:about="rdf:#173c8ac6-5251-41c2-b777-e75984be5795"/></rdf:_8><rdf:_7><rdf:Description rdf:about="rdf:#e5e98fcc-4795-42f1-8cab-161d422e40c3"/></rdf:_7><rdf:_11><rdf:Description rdf:about="rdf:#097127eb-5f0a-4bc1-9eef-af62b8638e1a"/></rdf:_11><rdf:_10><rdf:Description rdf:about="rdf:#5ff25bc5-cf6a-4cd1-bb0d-717b4fedd713"/></rdf:_10><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type></rdf:Description><rdf:Description rdf:about="#TRIO"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">TRIO</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">triosphosphate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#24b20a93-7e2b-4c6c-ad6a-bb78a61c46db"><EMAIL xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#8bd4ff19-5f5c-4419-b301-49d2da25af89"/></EMAIL><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#d5eaa377-be4d-4a11-8da5-7d505808dbcf"/></N><ORG xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#2142b85e-67d3-40d7-99c2-b0dca527aa8a"/></ORG></rdf:Description><rdf:Description rdf:about="rdf:#5a7f4dda-a178-49d9-9078-28a8dd43c40b"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Teusink</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Bas</Given></rdf:Description><rdf:Description rdf:about="rdf:#69927851-f209-4691-89c4-b58500a2d9c5"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Snoep</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Jacky</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">L</Other></rdf:Description><rdf:Description rdf:about="#F16P"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">F16P</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">fructose 1,6-bisphosphate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#411b37f6-c890-4c61-a78a-858ed9b7d098"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#fc960cc1-1cbc-4493-a793-082fd0b394ec"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#52d28beb-678c-42e6-897f-58018c21cf17"><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type><rdf:value><rdf:Description rdf:nodeID="n4"/></rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#04464991-7d2b-4d2e-ad72-dfab3534c53e"><rdf:value xml:lang="en">This CellML version of the model has been recoded to remove the reaction element.  The model has been opened in both PCEnv and COR and the units have been checked and are consistent.  However, unfortunately the model can not be run in either PCEnv or COR at the moment due to the presence of 'unsuitable constraints' (PCEnv) or 'circular arguments' (COR).  These coupled equations need to be solved iteratively at each time step.  We intend this feature to become a future development of our simulation tools. </rdf:value><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#d2c2ce2d-b326-445f-a320-64ca5865abd0"/></creator></rdf:Description><rdf:Description rdf:nodeID="n4"><rdf:_3 xml:lang="en">metabolism</rdf:_3><rdf:_1 xml:lang="en">glycoloysis</rdf:_1><rdf:_4 xml:lang="en">enzyme kinetics</rdf:_4><rdf:_2 xml:lang="en">yeast</rdf:_2><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/></rdf:type></rdf:Description><rdf:Description rdf:about="#ETOH"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">ETOH</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">ethanol</alternative></rdf:Description><rdf:Description rdf:about="#GLCi"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">GLCi</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">intracellular glucose</alternative></rdf:Description><rdf:Description rdf:nodeID="n3"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n1"/></boundIntervals></rdf:Description><rdf:Description rdf:about="rdf:#efa52486-96bd-4aa6-bee9-a98e562e3c58"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Passarge</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Jutta</Given></rdf:Description><rdf:Description rdf:about="rdf:#c9da28fd-2f47-42ad-83a9-e644a54235d6"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#f9bf34be-fa11-4658-9c15-9a4b6b726b65"/></N></rdf:Description><rdf:Description rdf:about="rdf:#8bd4ff19-5f5c-4419-b301-49d2da25af89"><rdf:value xml:lang="en">c.lloyd@auckland.ac.nz</rdf:value><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#fc866882-356e-47b7-89c8-692f4dc602d2"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#8256b0d9-6646-46e2-925a-64c69cf55ef8"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="#P"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">P</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">high energy phosphates</alternative></rdf:Description><rdf:Description rdf:about="#PYR"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">PYR</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">pyruvate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#dd5e9209-aafe-4a01-8f19-5ef5392808dc"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Reijenga</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Corrine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">A</Other></rdf:Description><rdf:Description rdf:about="rdf:#e5e98fcc-4795-42f1-8cab-161d422e40c3"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#1f1e5120-768c-4995-b24d-b9d558a9a349"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="#F6P"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">F6P</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">fructose 6-phosphate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#1f1e5120-768c-4995-b24d-b9d558a9a349"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Walsh</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Michael</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">C</Other></rdf:Description><rdf:Description rdf:about="rdf:#097127eb-5f0a-4bc1-9eef-af62b8638e1a"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#69927851-f209-4691-89c4-b58500a2d9c5"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#5a2b126b-b39b-4d8a-a502-95d15df4960a"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#52d28beb-678c-42e6-897f-58018c21cf17"/></subject></rdf:Description><rdf:Description rdf:about="rdf:#22ee34b6-b6ff-4d01-8424-d62e31619370"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">van der Weijden</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Coen</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">C</Other></rdf:Description><rdf:Description rdf:nodeID="n2"><maximumStepSize xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">0.1</maximumStepSize><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">5</endingValue></rdf:Description><rdf:Description rdf:about="rdf:#83c688ba-7501-4326-b311-4705b419fcde"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2003-05-12T00:00:00+00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#8013d42f-a14e-4c49-a784-3f5cee467ddc"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Bakker</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Barbara</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">M</Other></rdf:Description><rdf:Description rdf:about="#ATP"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">ATP</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">adenosine triphosphate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#be2692d4-6fdc-4b4c-8b54-1bf371db08f5"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">European Journal of Biochemistry</title></rdf:Description><rdf:Description rdf:about="rdf:#37bb0719-50cb-49df-b336-ef58837e22c7"><Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">10951190</Pubmed_id><JournalArticle xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#6306d9a5-1c34-4e59-8670-37ef3e2a3296"/></JournalArticle></rdf:Description><rdf:Description rdf:about="#F26P"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">F26P</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">fructose 2,6-bisphosphate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#6306d9a5-1c34-4e59-8670-37ef3e2a3296"><last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">5329</last_page><volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">267</volume><first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">5313</first_page><issued xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#6cca0ca9-c08b-467b-a624-88c89dc33cd9"/></issued><Journal xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#be2692d4-6fdc-4b4c-8b54-1bf371db08f5"/></Journal><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry.</title><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#2a66967d-8b92-4318-992b-e4043c06980e"/></creator></rdf:Description><rdf:Description rdf:about="rdf:#6cca0ca9-c08b-467b-a624-88c89dc33cd9"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2000-09-01</W3CDTF></rdf:Description><rdf:Description rdf:about="#GLCo"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">GLCo</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">extracellular glucose</alternative></rdf:Description><rdf:Description rdf:about="rdf:#c10e8244-a771-4ef8-9144-30886a49827b"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Westerhoff</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Hans</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">V</Other></rdf:Description><rdf:Description rdf:about="rdf:#f9bf34be-fa11-4658-9c15-9a4b6b726b65"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="#AMP"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">AMP</title><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">adenosine monophoshate</alternative></rdf:Description><rdf:Description rdf:about="rdf:#fb1a7687-6b95-44bf-804f-ce6a564a8829"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#dd5e9209-aafe-4a01-8f19-5ef5392808dc"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description></rdf:RDF></model>