- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2010-08-12 10:28:57+12:00
- Desc:
- Made ai and svg, added xul and clickable session file
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/terkildsen_niederer_crampin_hunter_smith_2008/rawfile/cebc92eb074b5acf345f88c53ca883169675bca3/terkildsen_niederer_crampin_hunter_smith_2008.cellml
<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="terkildsen_2008" name="terkildsen_2008">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
Since this is the exact same model encoding which was used to create the results presented in the paper, this CellML model is known to accurately represent the published article.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: Scientific endeavour is reliant upon the extension and reuse of previous knowledge. The formalization of this process for computational modelling is facilitated by the use of accepted standards with which to describe and simulate models, ensuring consistency between the models and thus reducing the development and propagation of errors. CellML 1.1, an XML-based programming language, has been designed as a modelling standard which, by virtue of its import and grouping functions, facilitates model combination and reuse. Using CellML 1.1, we demonstrate the process of formalized model reuse by combining three separate models of rat cardiomyocyte function (an electrophysiology model, a model of cellular calcium dynamics and a mechanics model) which together make up the Pandit-Hinch-Niederer et al. cell model. Not only is this integrative model of rat electromechanics a useful tool for cardiac modelling but it is also an ideal framework with which to demonstrate both the power of model reuse and the challenges associated with this process. We highlight and classify a number of these issues associated with combining models and provide some suggested solutions.
</para>
<para>
Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction, Jonna R. Terkildsen, Steven Niederer, Edmund J. Crampin, Peter Hunter and Nicolas P. Smith, 2008, <emphasis>Experimental Physiology</emphasis>, 93, 919-929. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=18344258&query_hl=1&itool=pubmed_docsum">PubMed ID: 18344258</ulink>
</para>
<informalfigure float="0" id="diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="terkildsen_2008.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the CellML model.</caption>
</informalfigure>
<para>
A CellML 1.1 version of this model is also available, which imports components from the Pandit et al. 2001, Hinch et al. 2004 and Niederer et al. 2006 models into a parent model.
</para>
</sect1>
</article>
</documentation>
<units name="uL">
<unit prefix="micro" units="litre"/>
</units>
<units name="uA">
<unit prefix="micro" units="ampere"/>
</units>
<units name="uF">
<unit prefix="micro" units="farad"/>
</units>
<units name="mSi">
<unit prefix="milli" units="siemens"/>
</units>
<units name="per_ms">
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="ms">
<unit prefix="milli" units="second"/>
</units>
<units name="mV">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_mV">
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<units name="mM">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="mM_per_ms">
<unit units="mM"/>
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="um3">
<unit exponent="3" prefix="micro" units="meter"/>
</units>
<units name="um3_per_ms">
<unit exponent="3" prefix="micro" units="meter"/>
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="um3_mM_per_ms">
<unit exponent="3" prefix="micro" units="meter"/>
<unit units="mM"/>
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="mM_per_mV_ms">
<unit units="mM"/>
<unit exponent="-1" prefix="milli" units="second"/>
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<units name="per_ms3">
<unit exponent="-3" prefix="milli" units="second"/>
</units>
<units name="per_mM_ms">
<unit exponent="-1" units="mM"/>
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="mJ_per_mole_K">
<unit prefix="milli" units="joule"/>
<unit exponent="-1" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="C_per_mole">
<unit units="coulomb"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="N_per_mm2">
<unit units="newton"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="ms"/>
</component>
<component name="membrane">
<variable cmeta:id="membrane_V" initial_value="-78.8" name="V" public_interface="out" units="mV"/>
<variable initial_value="8314.5" name="R" public_interface="out" units="mJ_per_mole_K"/>
<variable initial_value="295" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96487" name="F" public_interface="out" units="C_per_mole"/>
<variable name="time" public_interface="in" units="ms"/>
<variable initial_value="0.0001" name="Cm" units="uF"/>
<variable name="I_Stim" public_interface="out" units="uA"/>
<variable name="stim_period" units="ms"/>
<variable initial_value="10" name="stim_duration" units="ms"/>
<variable initial_value="-0.6e-3" name="stim_amplitude" units="uA"/>
<variable name="I_Na" public_interface="in" units="uA"/>
<variable name="I_t" public_interface="in" units="uA"/>
<variable name="I_ss" public_interface="in" units="uA"/>
<variable name="I_f" public_interface="in" units="uA"/>
<variable name="I_K1" public_interface="in" units="uA"/>
<variable name="I_B_Na" public_interface="in" units="uA"/>
<variable name="I_B_K" public_interface="in" units="uA"/>
<variable name="I_NaK" public_interface="in" units="uA"/>
<variable name="I_LCC" public_interface="in" units="uA"/>
<variable name="I_NaCa" public_interface="in" units="uA"/>
<variable name="I_pCa" public_interface="in" units="uA"/>
<variable name="I_CaB" public_interface="in" units="uA"/>
<variable name="FVRT" public_interface="out" units="dimensionless"/>
<variable name="FVRT_Ca" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>stim_period</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">500</cn>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">5000</cn>
</apply>
<apply>
<leq/>
<ci>time</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">10000</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1000</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>I_Stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<apply>
<minus/>
<ci>time</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<ci>time</ci>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">0</cn>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<ci>time</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<ci>time</ci>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>FVRT</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>FVRT_Ca</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>FVRT</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>I_Na</ci>
<ci>I_t</ci>
<ci>I_ss</ci>
<ci>I_f</ci>
<ci>I_K1</ci>
<ci>I_B_Na</ci>
<ci>I_B_K</ci>
<ci>I_NaK</ci>
<ci>I_Stim</ci>
<ci>I_CaB</ci>
<ci>I_NaCa</ci>
<ci>I_pCa</ci>
<ci>I_LCC</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
</component>
<component name="cell_geometry">
<variable initial_value="25.85e3" name="V_myo" public_interface="out" units="um3"/>
<variable initial_value="2.098e3" name="V_SR" public_interface="out" units="um3"/>
<variable initial_value="25.85e-6" name="V_myo_uL" public_interface="out" units="uL"/>
<variable initial_value="2.098e-6" name="V_SR_uL" public_interface="out" units="uL"/>
</component>
<component name="pandit_sodium_current">
<variable cmeta:id="pandit_sodium_current_i_Na" name="i_Na" public_interface="out" units="uA"/>
<variable name="E_Na" public_interface="out" units="mV"/>
<variable initial_value="0.8e-3" name="g_Na" units="mSi"/>
<variable name="g_Na_endo" units="mSi"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="mJ_per_mole_K"/>
<variable name="F" public_interface="in" units="C_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="m" private_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" units="dimensionless"/>
<variable name="j" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Na_endo</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.33</cn>
<ci>g_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na_endo</ci>
<apply>
<power/>
<ci>m</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<ci>j</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_m_gate">
<variable initial_value="0.0054828" name="m" public_interface="out" units="dimensionless"/>
<variable name="m_infinity" units="dimensionless"/>
<variable name="tau_m" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">45</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_m</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1.36</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.32</cn>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">47.13</cn>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.08</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>m_infinity</ci>
<ci>m</ci>
</apply>
<ci>tau_m</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_h_gate">
<variable initial_value="0.6095126" name="h" public_interface="out" units="dimensionless"/>
<variable name="h_infinity" units="dimensionless"/>
<variable name="tau_h" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>h_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">76.1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6.07</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_h</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">0.4537</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10.66</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11.1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<geq/>
<ci>V</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">3.49</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.135</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">80</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6.8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.56</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.079</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">310000</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.35</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>h_infinity</ci>
<ci>h</ci>
</apply>
<ci>tau_h</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_j_gate">
<variable initial_value="0.60876276" name="j" public_interface="out" units="dimensionless"/>
<variable name="j_infinity" units="dimensionless"/>
<variable name="tau_j" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">76.1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6.07</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">11.63</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">32</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.0000002535</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<geq/>
<ci>V</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">3.49</cn>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">37.78</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.311</cn>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">127140</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.2444</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.00003474</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.04391</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1212</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.01052</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1378</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>j</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>j_infinity</ci>
<ci>j</ci>
</apply>
<ci>tau_j</ci>
</apply>
</apply>
</math>
</component>
<component name="pandit_Ca_independent_transient_outward_K_current">
<variable cmeta:id="pandit_Ca_independent_transient_outward_K_current_i_t" name="i_t" public_interface="out" units="uA"/>
<variable name="E_K" public_interface="out" units="mV"/>
<variable initial_value="0.035e-3" name="g_t" units="mSi"/>
<variable name="g_t_endo" units="mSi"/>
<variable initial_value="0.583" name="a_endo" units="dimensionless"/>
<variable initial_value="0.417" name="b_endo" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="mJ_per_mole_K"/>
<variable name="F" public_interface="in" units="C_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="K_i" public_interface="in" units="mM"/>
<variable name="r" private_interface="in" units="dimensionless"/>
<variable name="s" private_interface="in" units="dimensionless"/>
<variable name="s_slow" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_t_endo</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4647</cn>
<ci>g_t</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_t</ci>
<apply>
<times/>
<ci>g_t_endo</ci>
<ci>r</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>a_endo</ci>
<ci>s</ci>
</apply>
<apply>
<times/>
<ci>b_endo</ci>
<ci>s_slow</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_r_gate">
<variable initial_value="0.002542" name="r" public_interface="out" units="dimensionless"/>
<variable name="tau_r" units="ms"/>
<variable name="r_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10.6</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11.42</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1000</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.03577</cn>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_s_gate">
<variable initial_value="0.8823" name="s" public_interface="out" units="dimensionless"/>
<variable name="tau_s_endo" units="ms"/>
<variable name="s_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">45.3</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_endo</ci>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">550</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">70</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">25</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">49</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_infinity</ci>
<ci>s</ci>
</apply>
<ci>tau_s_endo</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_s_slow_gate">
<variable initial_value="0.42756" name="s_slow" public_interface="out" units="dimensionless"/>
<variable name="tau_s_slow_endo" units="ms"/>
<variable name="s_slow_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_slow_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">45.3</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_slow_endo</ci>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">3300</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">70</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">30</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">49</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_slow</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_slow_infinity</ci>
<ci>s_slow</ci>
</apply>
<ci>tau_s_slow_endo</ci>
</apply>
</apply>
</math>
</component>
<component name="pandit_steady_state_outward_K_current">
<variable cmeta:id="pandit_steady_state_outward_K_current_i_ss" name="i_ss" public_interface="out" units="uA"/>
<variable initial_value="0.007e-3" name="g_ss" units="mSi"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="r_ss" private_interface="in" units="dimensionless"/>
<variable name="s_ss" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_ss</ci>
<apply>
<times/>
<ci>g_ss</ci>
<ci>r_ss</ci>
<ci>s_ss</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current_r_ss_gate">
<variable initial_value="0.0033545" name="r_ss" public_interface="out" units="dimensionless"/>
<variable name="tau_r_ss" units="ms"/>
<variable name="r_ss_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_ss_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11.5</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11.82</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r_ss</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">10000</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.03577</cn>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_ss_infinity</ci>
<ci>r_ss</ci>
</apply>
<ci>tau_r_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current_s_ss_gate">
<variable initial_value="0.266596" name="s_ss" public_interface="out" units="dimensionless"/>
<variable name="tau_s_ss" units="ms"/>
<variable name="s_ss_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_ss_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">87.5</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_ss</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">2100</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_ss_infinity</ci>
<ci>s_ss</ci>
</apply>
<ci>tau_s_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="pandit_inward_rectifier">
<variable cmeta:id="pandit_inward_rectifier_i_K1" name="i_K1" public_interface="out" units="uA"/>
<variable initial_value="0.024e-3" name="g_K1" units="mSi"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="mJ_per_mole_K"/>
<variable name="F" public_interface="in" units="C_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="K_i" public_interface="in" units="mM"/>
<variable name="E_K" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA">48e-3</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">37</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">25</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">37</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">25</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA">10e-3</cn>
</apply>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">76.77</cn>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">17</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.613</cn>
<ci>F</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>K_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.9988</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.124</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="pandit_hyperpolarisation_activated_current">
<variable cmeta:id="pandit_hyperpolarisation_activated_current_i_f" name="i_f" public_interface="out" units="uA"/>
<variable name="i_f_Na" public_interface="out" units="uA"/>
<variable name="i_f_K" public_interface="out" units="uA"/>
<variable initial_value="0.00145e-3" name="g_f" units="mSi"/>
<variable initial_value="0.2" name="f_Na" units="dimensionless"/>
<variable name="f_K" units="dimensionless"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="E_Na" public_interface="in" units="mV"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_K</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_Na</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>y</ci>
<ci>f_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_K</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>y</ci>
<ci>f_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f</ci>
<apply>
<plus/>
<ci>i_f_Na</ci>
<ci>i_f_K</ci>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current_y_gate">
<variable initial_value="0.0026369" name="y" public_interface="out" units="dimensionless"/>
<variable name="tau_y" units="ms"/>
<variable name="y_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_infinity</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">138.6</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10.48</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1000</cn>
<apply>
<plus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.11885</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">80</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">28.37</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5623</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">80</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">14.19</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
</math>
</component>
<component name="pandit_background_currents">
<variable cmeta:id="pandit_background_currents_i_B_Na" name="i_B_Na" public_interface="out" units="uA"/>
<variable name="i_B_K" public_interface="out" units="uA"/>
<variable initial_value="0.00008015e-3" name="g_B_Na" units="mSi"/>
<variable initial_value="0.000138e-3" name="g_B_K" units="mSi"/>
<variable name="E_Na" public_interface="in" units="mV"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>g_B_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_K</ci>
<apply>
<times/>
<ci>g_B_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="pandit_sodium_potassium_pump">
<variable cmeta:id="pandit_sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="uA"/>
<variable initial_value="0.95e-4" name="i_NaK_max" units="uA"/>
<variable initial_value="1.5" name="K_m_K" units="mM"/>
<variable initial_value="10" name="K_m_Na" units="mM"/>
<variable name="sigma" units="dimensionless"/>
<variable name="K_o" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="R" public_interface="in" units="mJ_per_mole_K"/>
<variable name="F" public_interface="in" units="C_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaK_max</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>K_m_K</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_m_Na</ci>
<ci>Na_i</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="pandit_standard_ionic_concentrations">
<variable initial_value="140" name="Na_o" public_interface="out" units="mM"/>
<variable initial_value="1.2" name="Ca_o" public_interface="out" units="mM"/>
<variable initial_value="5.4" name="K_o" public_interface="out" units="mM"/>
</component>
<component name="hinch_CaRU">
<variable initial_value="0.065" name="g_D" private_interface="out" units="um3_per_ms"/>
<variable initial_value="0.02" name="J_R" private_interface="out" units="um3_per_ms"/>
<variable initial_value="9.13e-4" name="J_L" private_interface="out" units="um3_per_ms"/>
<variable name="V_myo" private_interface="out" public_interface="in" units="um3"/>
<variable initial_value="50000" name="N" private_interface="out" units="dimensionless"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="Ca_i" private_interface="out" public_interface="in" units="mM"/>
<variable name="Ca_o" private_interface="out" public_interface="in" units="mM"/>
<variable name="Ca_SR" private_interface="out" public_interface="in" units="mM"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="FVRT_Ca" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="I_RyR" private_interface="in" public_interface="out" units="mM_per_ms"/>
<variable name="I_LCC" private_interface="in" public_interface="out" units="mM_per_ms"/>
</component>
<component name="CaRU_Transitions">
<variable name="V" public_interface="in" units="mV"/>
<variable name="C_oc" public_interface="in" units="mM"/>
<variable name="C_co" public_interface="in" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable initial_value="-2" name="V_L" units="mV"/>
<variable initial_value="7" name="del_VL" units="mV"/>
<variable initial_value="2.35" name="phi_L" units="dimensionless"/>
<variable initial_value="1" name="t_L" units="ms"/>
<variable initial_value="650" name="tau_L" units="ms"/>
<variable name="t_R" units="ms"/>
<variable initial_value="2.43" name="tau_R" units="ms"/>
<variable initial_value="0.05" name="phi_R" units="dimensionless"/>
<variable initial_value="0.012" name="theta_R" units="dimensionless"/>
<variable initial_value="41e-3" name="K_RyR" units="mM"/>
<variable initial_value="0.22e-3" name="K_L" units="mM"/>
<variable initial_value="0.0625" name="a" units="dimensionless"/>
<variable initial_value="14" name="b" units="dimensionless"/>
<variable initial_value="0.01" name="c" units="dimensionless"/>
<variable initial_value="100" name="d" units="dimensionless"/>
<variable name="expVL" units="dimensionless"/>
<variable name="alpha_p" public_interface="out" units="per_ms"/>
<variable name="alpha_m" public_interface="out" units="per_ms"/>
<variable name="beta_poc" public_interface="out" units="per_ms"/>
<variable name="beta_pcc" public_interface="out" units="per_ms"/>
<variable name="beta_m" public_interface="out" units="per_ms"/>
<variable name="epsilon_pco" public_interface="out" units="per_ms"/>
<variable name="epsilon_pcc" public_interface="out" units="per_ms"/>
<variable name="epsilon_m" public_interface="out" units="per_ms"/>
<variable name="mu_poc" public_interface="out" units="per_ms"/>
<variable name="mu_pcc" public_interface="out" units="per_ms"/>
<variable name="mu_moc" public_interface="out" units="per_ms"/>
<variable name="mu_mcc" public_interface="out" units="per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>expVL</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<ci>V_L</ci>
</apply>
<ci>del_VL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>t_R</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.17</cn>
<ci>t_L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_p</ci>
<apply>
<divide/>
<ci>expVL</ci>
<apply>
<times/>
<ci>t_L</ci>
<apply>
<plus/>
<ci>expVL</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<ci>phi_L</ci>
<ci>t_L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_poc</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>t_R</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_pcc</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>t_R</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<divide/>
<ci>phi_R</ci>
<ci>t_R</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon_pco</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C_co</ci>
<apply>
<plus/>
<ci>expVL</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<times/>
<ci>tau_L</ci>
<ci>K_L</ci>
<apply>
<plus/>
<ci>expVL</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon_pcc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<plus/>
<ci>expVL</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<times/>
<ci>tau_L</ci>
<ci>K_L</ci>
<apply>
<plus/>
<ci>expVL</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon_m</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>b</ci>
<apply>
<plus/>
<ci>expVL</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<times/>
<ci>tau_L</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>b</ci>
<ci>expVL</ci>
</apply>
<ci>a</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_poc</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<power/>
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>tau_R</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_pcc</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>tau_R</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_moc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>theta_R</ci>
<ci>d</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>tau_R</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>d</ci>
<apply>
<power/>
<ci>C_oc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mcc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>theta_R</ci>
<ci>d</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>tau_R</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>d</ci>
<apply>
<power/>
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="DS_Calcium_Concentrations">
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_SR" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="FVRT_Ca" public_interface="in" units="dimensionless"/>
<variable name="g_D" public_interface="in" units="um3_per_ms"/>
<variable name="J_R" public_interface="in" units="um3_per_ms"/>
<variable name="J_L" public_interface="in" units="um3_per_ms"/>
<variable name="C_cc" public_interface="out" units="mM"/>
<variable name="C_oc" public_interface="out" units="mM"/>
<variable name="C_co" public_interface="out" units="mM"/>
<variable name="C_oo" public_interface="out" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C_cc</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<eq/>
<ci>C_co</ci>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C_oc</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
<ci>FVRT_Ca</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000000001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>C_oo</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_SR</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
<ci>FVRT_Ca</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000000001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_SR</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="LCC_and_RyR_fluxes">
<variable name="g_D" public_interface="in" units="um3_per_ms"/>
<variable name="J_R" public_interface="in" units="um3_per_ms"/>
<variable name="J_L" public_interface="in" units="um3_per_ms"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_SR" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="FVRT_Ca" public_interface="in" units="dimensionless"/>
<variable name="J_Loo" public_interface="out" units="um3_mM_per_ms"/>
<variable name="J_Loc" public_interface="out" units="um3_mM_per_ms"/>
<variable name="J_Rco" public_interface="out" units="um3_mM_per_ms"/>
<variable name="J_Roo" public_interface="out" units="um3_mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_Rco</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>J_R</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Roo</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>J_R</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_SR</ci>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>J_R</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_SR</ci>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>J_Loc</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_L</ci>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_L</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>J_Loo</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_L</ci>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_L</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="CaRU_states">
<variable name="alpha_p" public_interface="in" units="per_ms"/>
<variable name="alpha_m" public_interface="in" units="per_ms"/>
<variable name="beta_pcc" public_interface="in" units="per_ms"/>
<variable name="beta_poc" public_interface="in" units="per_ms"/>
<variable name="beta_m" public_interface="in" units="per_ms"/>
<variable name="denom" units="per_ms3"/>
<variable name="y_oc" public_interface="out" units="dimensionless"/>
<variable name="y_co" public_interface="out" units="dimensionless"/>
<variable name="y_oo" public_interface="out" units="dimensionless"/>
<variable name="y_cc" public_interface="out" units="dimensionless"/>
<variable name="y_ci" public_interface="out" units="dimensionless"/>
<variable name="y_oi" public_interface="out" units="dimensionless"/>
<variable name="y_ic" public_interface="out" units="dimensionless"/>
<variable name="y_io" public_interface="out" units="dimensionless"/>
<variable name="y_ii" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>denom</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
<apply>
<plus/>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_p</ci>
<apply>
<plus/>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_oc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_p</ci>
<ci>beta_m</ci>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>y_co</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_pcc</ci>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_poc</ci>
<ci>alpha_p</ci>
</apply>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>y_oo</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_p</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_poc</ci>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_pcc</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>y_cc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>alpha_p</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>y_ci</ci>
<apply>
<divide/>
<ci>alpha_m</ci>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_oi</ci>
<apply>
<divide/>
<ci>alpha_p</ci>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_ic</ci>
<apply>
<divide/>
<ci>beta_m</ci>
<apply>
<plus/>
<ci>beta_pcc</ci>
<ci>beta_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_io</ci>
<apply>
<divide/>
<ci>beta_pcc</ci>
<apply>
<plus/>
<ci>beta_pcc</ci>
<ci>beta_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_ii</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>y_oc</ci>
</apply>
<ci>y_co</ci>
</apply>
<ci>y_oo</ci>
</apply>
<ci>y_cc</ci>
</apply>
<ci>y_ci</ci>
</apply>
<ci>y_ic</ci>
</apply>
<ci>y_oi</ci>
</apply>
<ci>y_io</ci>
</apply>
</apply>
</math>
</component>
<component name="CaRU_reduced_states">
<variable name="y_oc" public_interface="in" units="dimensionless"/>
<variable name="y_cc" public_interface="in" units="dimensionless"/>
<variable name="y_co" public_interface="in" units="dimensionless"/>
<variable name="alpha_p" public_interface="in" units="per_ms"/>
<variable name="alpha_m" public_interface="in" units="per_ms"/>
<variable name="beta_pcc" public_interface="in" units="per_ms"/>
<variable name="beta_m" public_interface="in" units="per_ms"/>
<variable name="epsilon_pco" public_interface="in" units="per_ms"/>
<variable name="epsilon_pcc" public_interface="in" units="per_ms"/>
<variable name="epsilon_m" public_interface="in" units="per_ms"/>
<variable name="mu_poc" public_interface="in" units="per_ms"/>
<variable name="mu_pcc" public_interface="in" units="per_ms"/>
<variable name="mu_moc" public_interface="in" units="per_ms"/>
<variable name="mu_mcc" public_interface="in" units="per_ms"/>
<variable name="r_1" public_interface="out" units="per_ms"/>
<variable name="r_2" public_interface="out" units="per_ms"/>
<variable name="r_3" public_interface="out" units="per_ms"/>
<variable name="r_4" public_interface="out" units="per_ms"/>
<variable name="r_5" public_interface="out" units="per_ms"/>
<variable name="r_6" public_interface="out" units="per_ms"/>
<variable name="r_7" public_interface="out" units="per_ms"/>
<variable name="r_8" public_interface="out" units="per_ms"/>
<variable initial_value="0.98794" name="z_1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.00887" name="z_2" public_interface="out" units="dimensionless"/>
<variable initial_value="0.003156" name="z_3" public_interface="out" units="dimensionless"/>
<variable name="z_4" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>y_oc</ci>
<ci>mu_poc</ci>
</apply>
<apply>
<times/>
<ci>y_cc</ci>
<ci>mu_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_2</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_p</ci>
<ci>mu_moc</ci>
</apply>
<apply>
<times/>
<ci>alpha_m</ci>
<ci>mu_mcc</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_m</ci>
<ci>mu_pcc</ci>
</apply>
<apply>
<plus/>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_4</ci>
<ci>mu_mcc</ci>
</apply>
<apply>
<eq/>
<ci>r_5</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>y_co</ci>
<ci>epsilon_pco</ci>
</apply>
<apply>
<times/>
<ci>y_cc</ci>
<ci>epsilon_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_6</ci>
<ci>epsilon_m</ci>
</apply>
<apply>
<eq/>
<ci>r_7</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_m</ci>
<ci>epsilon_pcc</ci>
</apply>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_8</ci>
<ci>epsilon_m</ci>
</apply>
<apply>
<eq/>
<ci>z_4</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>z_1</ci>
</apply>
<ci>z_2</ci>
</apply>
<ci>z_3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>z_1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>r_1</ci>
<ci>r_5</ci>
</apply>
</apply>
<ci>z_1</ci>
</apply>
<apply>
<times/>
<ci>r_2</ci>
<ci>z_2</ci>
</apply>
<apply>
<times/>
<ci>r_6</ci>
<ci>z_3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>z_2</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>r_1</ci>
<ci>z_1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>r_2</ci>
<ci>r_7</ci>
</apply>
<ci>z_2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>r_8</ci>
<ci>z_4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>z_3</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>r_5</ci>
<ci>z_1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>r_6</ci>
<ci>r_3</ci>
</apply>
<ci>z_3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>r_4</ci>
<ci>z_4</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RyR_current">
<variable name="y_oo" public_interface="in" units="dimensionless"/>
<variable name="y_co" public_interface="in" units="dimensionless"/>
<variable name="y_oc" public_interface="in" units="dimensionless"/>
<variable name="beta_pcc" public_interface="in" units="per_ms"/>
<variable name="beta_m" public_interface="in" units="per_ms"/>
<variable name="J_Roo" public_interface="in" units="um3_mM_per_ms"/>
<variable name="J_Rco" public_interface="in" units="um3_mM_per_ms"/>
<variable name="z_1" public_interface="in" units="dimensionless"/>
<variable name="z_3" public_interface="in" units="dimensionless"/>
<variable name="V_myo" public_interface="in" units="um3"/>
<variable name="N" public_interface="in" units="dimensionless"/>
<variable name="J_R1" public_interface="out" units="um3_mM_per_ms"/>
<variable name="J_R3" public_interface="out" units="um3_mM_per_ms"/>
<variable cmeta:id="RyR_current_I_RyR" name="I_RyR" public_interface="out" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_R1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>y_oo</ci>
<ci>J_Roo</ci>
</apply>
<apply>
<times/>
<ci>J_Rco</ci>
<ci>y_co</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_R3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>J_Rco</ci>
<ci>beta_pcc</ci>
</apply>
<apply>
<plus/>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_RyR</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>z_1</ci>
<ci>J_R1</ci>
</apply>
<apply>
<times/>
<ci>z_3</ci>
<ci>J_R3</ci>
</apply>
</apply>
<ci>N</ci>
</apply>
<ci>V_myo</ci>
</apply>
</apply>
</math>
</component>
<component name="LCC_current">
<variable name="y_oo" public_interface="in" units="dimensionless"/>
<variable name="y_oc" public_interface="in" units="dimensionless"/>
<variable name="alpha_p" public_interface="in" units="per_ms"/>
<variable name="alpha_m" public_interface="in" units="per_ms"/>
<variable name="J_Loo" public_interface="in" units="um3_mM_per_ms"/>
<variable name="J_Loc" public_interface="in" units="um3_mM_per_ms"/>
<variable name="z_1" public_interface="in" units="dimensionless"/>
<variable name="z_2" public_interface="in" units="dimensionless"/>
<variable name="V_myo" public_interface="in" units="um3"/>
<variable name="N" public_interface="in" units="dimensionless"/>
<variable name="J_L1" public_interface="out" units="um3_mM_per_ms"/>
<variable name="J_L2" public_interface="out" units="um3_mM_per_ms"/>
<variable cmeta:id="LCC_current_I_LCC" name="I_LCC" public_interface="out" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_L1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>J_Loo</ci>
<ci>y_oo</ci>
</apply>
<apply>
<times/>
<ci>J_Loc</ci>
<ci>y_oc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_L2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>J_Loc</ci>
<ci>alpha_p</ci>
</apply>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_LCC</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>z_1</ci>
<ci>J_L1</ci>
</apply>
<apply>
<times/>
<ci>z_2</ci>
<ci>J_L2</ci>
</apply>
</apply>
<ci>N</ci>
</apply>
<ci>V_myo</ci>
</apply>
</apply>
</math>
</component>
<component name="hinch_Na_Ca_Exchanger">
<variable name="FVRT" public_interface="in" units="dimensionless"/>
<variable initial_value="87.5" name="K_mNa" units="mM"/>
<variable initial_value="1380e-3" name="K_mCa" units="mM"/>
<variable initial_value="0.35" name="eta" units="dimensionless"/>
<variable initial_value="0.1" name="k_sat" units="dimensionless"/>
<variable initial_value="38.5e-3" name="g_NCX" units="mM_per_ms"/>
<variable name="Na_i" public_interface="in" units="mM"/>
<variable name="Na_o" public_interface="in" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable cmeta:id="hinch_Na_Ca_Exchanger_I_NaCa" name="I_NaCa" public_interface="out" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_NCX</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<ci>eta</ci>
<ci>FVRT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>FVRT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>K_mNa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>Ca_o</ci>
<ci>K_mCa</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>FVRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hinch_SERCA">
<variable initial_value="0.45e-3" name="g_SERCA" units="mM_per_ms"/>
<variable initial_value="0.5e-3" name="K_SERCA" units="mM"/>
<variable cmeta:id="hinch_SERCA_I_SERCA" name="I_SERCA" public_interface="out" units="mM_per_ms"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_SERCA</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_SERCA</ci>
<apply>
<power/>
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_SERCA</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hinch_Sarcolemmal_Ca_pump">
<variable initial_value="0.0035e-3" name="g_pCa" units="mM_per_ms"/>
<variable initial_value="0.5e-3" name="K_mpCa" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable cmeta:id="hinch_Sarcolemmal_Ca_pump_I_pCa" name="I_pCa" public_interface="out" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_pCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_pCa</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>K_mpCa</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hinch_Background_Ca_current">
<variable name="V" public_interface="in" units="mV"/>
<variable name="R" public_interface="in" units="mJ_per_mole_K"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="C_per_mole"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_o" public_interface="in" units="mM"/>
<variable name="E_Ca" public_interface="out" units="mV"/>
<variable initial_value="2.6875e-8" name="g_CaB" units="mM_per_mV_ms"/>
<variable cmeta:id="hinch_Background_Ca_current_I_CaB" name="I_CaB" public_interface="out" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CaB</ci>
<apply>
<times/>
<ci>g_CaB</ci>
<apply>
<minus/>
<ci>E_Ca</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hinch_SR_Ca_leak_current">
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="Ca_SR" public_interface="in" units="mM"/>
<variable initial_value="1.8951e-5" name="g_SRl" units="per_ms"/>
<variable cmeta:id="hinch_SR_Ca_leak_current_I_SR" name="I_SR" public_interface="out" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_SR</ci>
<apply>
<times/>
<ci>g_SRl</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hinch_calmodulin_Ca_buffer">
<variable initial_value="2.382e-3" name="k_CMDN" units="mM"/>
<variable initial_value="50e-3" name="B_CMDN" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="beta_CMDN" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>beta_CMDN</ci>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>k_CMDN</ci>
<ci>B_CMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>k_CMDN</ci>
<ci>Ca_i</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="convert_hinch">
<variable name="F" public_interface="in" units="C_per_mole"/>
<variable name="V_myo_uL" public_interface="in" units="uL"/>
<variable name="hinch_I_LCC" public_interface="in" units="mM_per_ms"/>
<variable name="hinch_I_NaCa" public_interface="in" units="mM_per_ms"/>
<variable name="hinch_I_pCa" public_interface="in" units="mM_per_ms"/>
<variable name="hinch_I_CaB" public_interface="in" units="mM_per_ms"/>
<variable name="hinch_I_RyR" public_interface="in" units="mM_per_ms"/>
<variable name="I_LCC" public_interface="out" units="uA"/>
<variable name="I_NaCa" public_interface="out" units="uA"/>
<variable name="I_pCa" public_interface="out" units="uA"/>
<variable name="I_CaB" public_interface="out" units="uA"/>
<variable name="I_RyR" public_interface="out" units="mM_per_ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_LCC</ci>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
</apply>
<ci>hinch_I_LCC</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>V_myo_uL</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NaCa</ci>
<apply>
<times/>
<ci>hinch_I_NaCa</ci>
<ci>V_myo_uL</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_pCa</ci>
<apply>
<times/>
<ci>hinch_I_pCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>V_myo_uL</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CaB</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>hinch_I_CaB</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>V_myo_uL</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_RyR</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
<ci>hinch_I_RyR</ci>
</apply>
</apply>
</math>
</component>
<component name="niederer_thinfilaments"/>
<component name="niederer_tropomyosin">
<variable initial_value="0.020023" name="z" public_interface="out" units="dimensionless"/>
<variable name="z_max" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="k_on" public_interface="in" units="per_mM_ms"/>
<variable name="k_Ref_off" public_interface="in" units="per_ms"/>
<variable name="gamma_trpn" public_interface="in" units="dimensionless"/>
<variable name="Ca_TRPN_Max" public_interface="in" units="mM"/>
<variable initial_value="8e-3" name="alpha_0" units="per_ms"/>
<variable initial_value="2e-3" name="alpha_r1" units="per_ms"/>
<variable initial_value="1.75e-3" name="alpha_r2" units="per_ms"/>
<variable initial_value="3" name="n_Rel" units="dimensionless"/>
<variable initial_value="0.15" name="K_z" units="dimensionless"/>
<variable initial_value="3" name="n_Hill" units="dimensionless"/>
<variable initial_value="1.05e-3" name="Ca_50ref" units="mM"/>
<variable initial_value="0.85" name="z_p" units="dimensionless"/>
<variable initial_value="-4" name="beta_1" units="dimensionless"/>
<variable name="Ca_50" units="mM"/>
<variable name="Ca_TRPN_50" units="mM"/>
<variable name="K_2" units="per_ms"/>
<variable name="K_1" units="per_ms"/>
<variable name="alpha_Tm" units="per_ms"/>
<variable name="beta_Tm" units="per_ms"/>
<variable name="beta_0" public_interface="in" units="dimensionless"/>
<variable name="Ca_b" public_interface="in" units="mM"/>
<variable name="lambda" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K_2</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_r2</ci>
<apply>
<power/>
<ci>z_p</ci>
<ci>n_Rel</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>z_p</ci>
<ci>n_Rel</ci>
</apply>
<apply>
<power/>
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>n_Rel</ci>
<apply>
<power/>
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>z_p</ci>
<ci>n_Rel</ci>
</apply>
<apply>
<power/>
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_r2</ci>
<apply>
<power/>
<ci>z_p</ci>
<apply>
<minus/>
<ci>n_Rel</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>n_Rel</ci>
<apply>
<power/>
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>z_p</ci>
<ci>n_Rel</ci>
</apply>
<apply>
<power/>
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>z_max</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<divide/>
<ci>alpha_0</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_TRPN_50</ci>
<ci>Ca_TRPN_Max</ci>
</apply>
<ci>n_Hill</ci>
</apply>
</apply>
<ci>K_2</ci>
</apply>
<apply>
<plus/>
<ci>alpha_r1</ci>
<ci>K_1</ci>
<apply>
<divide/>
<ci>alpha_0</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_TRPN_50</ci>
<ci>Ca_TRPN_Max</ci>
</apply>
<ci>n_Hill</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ca_50</ci>
<apply>
<times/>
<ci>Ca_50ref</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta_1</ci>
<apply>
<minus/>
<ci>lambda</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ca_TRPN_50</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_50</ci>
<ci>Ca_TRPN_Max</ci>
</apply>
<apply>
<plus/>
<ci>Ca_50</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>k_Ref_off</ci>
<ci>k_on</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta_0</ci>
<apply>
<minus/>
<ci>lambda</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
</apply>
<ci>gamma_trpn</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Tm</ci>
<apply>
<times/>
<ci>alpha_0</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_b</ci>
<ci>Ca_TRPN_50</ci>
</apply>
<ci>n_Hill</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Tm</ci>
<apply>
<plus/>
<ci>alpha_r1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_r2</ci>
<apply>
<power/>
<ci>z</ci>
<apply>
<minus/>
<ci>n_Rel</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>z</ci>
<ci>n_Rel</ci>
</apply>
<apply>
<power/>
<ci>K_z</ci>
<ci>n_Rel</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>z</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_Tm</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>z</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_Tm</ci>
<ci>z</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="niederer_troponin">
<variable name="I_TRPN" public_interface="out" units="mM_per_ms"/>
<variable initial_value="70e-3" name="Ca_TRPN_Max" public_interface="out" units="mM"/>
<variable name="TRPN" public_interface="in" units="mM"/>
<variable name="Ca_i" public_interface="in" units="mM"/>
<variable name="k_off" units="per_ms"/>
<variable initial_value="100" name="k_on" public_interface="out" units="per_mM_ms"/>
<variable initial_value="0.2" name="k_Ref_off" public_interface="out" units="per_ms"/>
<variable initial_value="2" name="gamma_trpn" public_interface="out" units="dimensionless"/>
<variable name="Tension" public_interface="in" units="N_per_mm2"/>
<variable name="T_ref" public_interface="in" units="N_per_mm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_off</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>k_Ref_off</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Tension</ci>
<apply>
<times/>
<ci>gamma_trpn</ci>
<ci>T_ref</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Tension</ci>
<apply>
<times/>
<ci>gamma_trpn</ci>
<ci>T_ref</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>k_Ref_off</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>I_TRPN</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<ci>Ca_TRPN_Max</ci>
<ci>TRPN</ci>
</apply>
<ci>k_off</ci>
</apply>
<apply>
<times/>
<ci>Ca_i</ci>
<ci>TRPN</ci>
<ci>k_on</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="niederer_Myofilaments">
<variable name="time" public_interface="in" units="ms"/>
<variable name="lambda" public_interface="out" units="dimensionless"/>
<variable name="ExtensionRatio" public_interface="out" units="dimensionless"/>
<variable name="dExtensionRatiodt" public_interface="out" units="per_ms"/>
<variable name="lambda_prev" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ExtensionRatio</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<gt/>
<ci>time</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">3e5</cn>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>lambda_prev</ci>
<ci>ExtensionRatio</ci>
</apply>
<apply>
<eq/>
<ci>dExtensionRatiodt</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
</apply>
<apply>
<eq/>
<ci>lambda</ci>
<piecewise>
<piece>
<ci>ExtensionRatio</ci>
<apply>
<and/>
<apply>
<gt/>
<ci>ExtensionRatio</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
</apply>
<apply>
<leq/>
<ci>ExtensionRatio</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.15</cn>
</apply>
</apply>
</piece>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.15</cn>
<apply>
<gt/>
<ci>ExtensionRatio</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.15</cn>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="niederer_filament_overlap">
<variable name="lambda" public_interface="in" units="dimensionless"/>
<variable name="overlap" public_interface="out" units="dimensionless"/>
<variable initial_value="4.9" name="beta_0" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>overlap</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta_0</ci>
<apply>
<minus/>
<ci>lambda</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="niederer_length_independent_tension">
<variable initial_value="56.2" name="T_ref" public_interface="out" units="N_per_mm2"/>
<variable name="T_Base" public_interface="out" units="N_per_mm2"/>
<variable name="z" public_interface="in" units="dimensionless"/>
<variable name="z_max" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_Base</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>T_ref</ci>
<ci>z</ci>
</apply>
<ci>z_max</ci>
</apply>
</apply>
</math>
</component>
<component name="niederer_isometric_tension">
<variable cmeta:id="niederer_isometric_tension_T_0" name="T_0" public_interface="out" units="N_per_mm2"/>
<variable name="T_Base" public_interface="in" units="N_per_mm2"/>
<variable name="overlap" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_0</ci>
<apply>
<times/>
<ci>T_Base</ci>
<ci>overlap</ci>
</apply>
</apply>
</math>
</component>
<component name="niederer_Cross_Bridges">
<variable name="time" public_interface="in" units="ms"/>
<variable name="dExtensionRatiodt" public_interface="in" units="per_ms"/>
<variable name="Q" units="dimensionless"/>
<variable initial_value="0.35" name="a" units="dimensionless"/>
<variable initial_value="0" name="Q_1" units="dimensionless"/>
<variable initial_value="0" name="Q_2" units="dimensionless"/>
<variable initial_value="0" name="Q_3" units="dimensionless"/>
<variable initial_value="-29" name="A_1" units="dimensionless"/>
<variable initial_value="138" name="A_2" units="dimensionless"/>
<variable initial_value="129" name="A_3" units="dimensionless"/>
<variable initial_value="0.03" name="alpha_1" units="per_ms"/>
<variable initial_value="0.13" name="alpha_2" units="per_ms"/>
<variable initial_value="0.625" name="alpha_3" units="per_ms"/>
<variable name="T_0" public_interface="in" units="N_per_mm2"/>
<variable name="Tension" public_interface="out" units="N_per_mm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q</ci>
<apply>
<plus/>
<ci>Q_1</ci>
<ci>Q_2</ci>
<ci>Q_3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Tension</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>T_0</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>a</ci>
<ci>Q</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>Q</ci>
</apply>
</apply>
<apply>
<lt/>
<ci>Q</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>T_0</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<plus/>
<ci>a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>Q</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>Q</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Q_1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>A_1</ci>
<ci>dExtensionRatiodt</ci>
</apply>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>Q_1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Q_2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>A_2</ci>
<ci>dExtensionRatiodt</ci>
</apply>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>Q_2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Q_3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>A_3</ci>
<ci>dExtensionRatiodt</ci>
</apply>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>Q_3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_ion_concentrations">
<variable initial_value="11.28" name="Na_i" public_interface="out" units="mM"/>
<variable cmeta:id="intracellular_ion_concentrations_Ca_i" initial_value="0.00011423" name="Ca_i" public_interface="out" units="mM"/>
<variable initial_value="721.96e-3" name="Ca_SR" public_interface="out" units="mM"/>
<variable initial_value="138.7225" name="K_i" public_interface="out" units="mM"/>
<variable initial_value="0.0661796" name="TRPN" public_interface="out" units="mM"/>
<variable name="V_myo_uL" public_interface="in" units="uL"/>
<variable name="V_SR_uL" public_interface="in" units="uL"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="F" public_interface="in" units="C_per_mole"/>
<variable name="I_Na" public_interface="in" units="uA"/>
<variable name="I_B_Na" public_interface="in" units="uA"/>
<variable name="I_B_K" public_interface="in" units="uA"/>
<variable name="I_NaK" public_interface="in" units="uA"/>
<variable name="I_f_Na" public_interface="in" units="uA"/>
<variable name="I_f_K" public_interface="in" units="uA"/>
<variable name="I_K1" public_interface="in" units="uA"/>
<variable name="I_t" public_interface="in" units="uA"/>
<variable name="I_ss" public_interface="in" units="uA"/>
<variable name="I_Stim" public_interface="in" units="uA"/>
<variable name="I_RyR" public_interface="in" units="mM_per_ms"/>
<variable name="I_LCC" public_interface="in" units="uA"/>
<variable name="I_NaCa" public_interface="in" units="uA"/>
<variable name="I_SERCA" public_interface="in" units="mM_per_ms"/>
<variable name="I_pCa" public_interface="in" units="uA"/>
<variable name="I_CaB" public_interface="in" units="uA"/>
<variable name="I_SR" public_interface="in" units="mM_per_ms"/>
<variable name="I_TRPN" public_interface="in" units="mM_per_ms"/>
<variable name="beta_CMDN" public_interface="in" units="dimensionless"/>
<variable name="Ca_b" public_interface="out" units="mM"/>
<variable name="Ca_TRPN_Max" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Ca_b</ci>
<apply>
<minus/>
<ci>Ca_TRPN_Max</ci>
<ci>TRPN</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>I_Na</ci>
<ci>I_B_Na</ci>
<apply>
<times/>
<ci>I_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>I_NaK</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>I_f_Na</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>V_myo_uL</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>I_Stim</ci>
<ci>I_ss</ci>
<ci>I_B_K</ci>
<ci>I_t</ci>
<ci>I_K1</ci>
<ci>I_f_K</ci>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>I_NaK</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>V_myo_uL</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>TRPN</ci>
</apply>
<ci>I_TRPN</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>beta_CMDN</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>I_RyR</ci>
<ci>I_SERCA</ci>
</apply>
<ci>I_SR</ci>
<ci>I_TRPN</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>I_NaCa</ci>
</apply>
<ci>I_pCa</ci>
<ci>I_CaB</ci>
<ci>I_LCC</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>V_myo_uL</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SR</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>V_myo_uL</ci>
<ci>V_SR_uL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>I_RyR</ci>
</apply>
<ci>I_SERCA</ci>
</apply>
<ci>I_SR</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="pandit_sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
<component_ref component="sodium_current_j_gate"/>
</component_ref>
<component_ref component="pandit_Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="pandit_steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="pandit_inward_rectifier"/>
<component_ref component="pandit_hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="pandit_background_currents"/>
<component_ref component="pandit_sodium_potassium_pump"/>
<component_ref component="pandit_standard_ionic_concentrations"/>
<component_ref component="intracellular_ion_concentrations"/>
<component_ref component="cell_geometry"/>
<component_ref component="hinch_CaRU">
<component_ref component="CaRU_Transitions"/>
<component_ref component="DS_Calcium_Concentrations"/>
<component_ref component="LCC_and_RyR_fluxes"/>
<component_ref component="CaRU_states"/>
<component_ref component="CaRU_reduced_states"/>
<component_ref component="RyR_current"/>
<component_ref component="LCC_current"/>
</component_ref>
<component_ref component="hinch_Na_Ca_Exchanger"/>
<component_ref component="hinch_SERCA"/>
<component_ref component="hinch_Sarcolemmal_Ca_pump"/>
<component_ref component="hinch_Background_Ca_current"/>
<component_ref component="hinch_SR_Ca_leak_current"/>
<component_ref component="hinch_calmodulin_Ca_buffer"/>
<component_ref component="convert_hinch"/>
</component_ref>
<component_ref component="niederer_Myofilaments">
<component_ref component="niederer_thinfilaments">
<component_ref component="niederer_tropomyosin"/>
<component_ref component="niederer_troponin"/>
</component_ref>
<component_ref component="niederer_filament_overlap"/>
<component_ref component="niederer_Cross_Bridges"/>
<component_ref component="niederer_isometric_tension"/>
<component_ref component="niederer_length_independent_tension"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="pandit_sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
<component_ref component="sodium_current_j_gate"/>
</component_ref>
<component_ref component="pandit_Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="pandit_steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="pandit_hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="hinch_CaRU">
<component_ref component="CaRU_Transitions"/>
<component_ref component="CaRU_states"/>
<component_ref component="CaRU_reduced_states"/>
<component_ref component="DS_Calcium_Concentrations"/>
<component_ref component="LCC_and_RyR_fluxes"/>
<component_ref component="RyR_current"/>
<component_ref component="LCC_current"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="pandit_steady_state_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="pandit_hyperpolarisation_activated_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="I_Stim" variable_2="I_Stim"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="membrane"/>
<map_variables variable_1="i_Na" variable_2="I_Na"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="membrane"/>
<map_variables variable_1="i_t" variable_2="I_t"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="pandit_steady_state_outward_K_current" component_2="membrane"/>
<map_variables variable_1="i_ss" variable_2="I_ss"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_inward_rectifier" component_2="membrane"/>
<map_variables variable_1="i_K1" variable_2="I_K1"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="pandit_hyperpolarisation_activated_current" component_2="membrane"/>
<map_variables variable_1="i_f" variable_2="I_f"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_background_currents" component_2="membrane"/>
<map_variables variable_1="i_B_Na" variable_2="I_B_Na"/>
<map_variables variable_1="i_B_K" variable_2="I_B_K"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_potassium_pump" component_2="membrane"/>
<map_variables variable_1="i_NaK" variable_2="I_NaK"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca"/>
</connection>
<connection>
<map_components component_1="hinch_Na_Ca_Exchanger" component_2="membrane"/>
<map_variables variable_1="FVRT" variable_2="FVRT"/>
</connection>
<connection>
<map_components component_1="hinch_Background_Ca_current" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Na" variable_2="I_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_t" variable_2="I_t"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="pandit_steady_state_outward_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_ss" variable_2="I_ss"/>
</connection>
<connection>
<map_components component_1="pandit_inward_rectifier" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_K1" variable_2="I_K1"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="pandit_hyperpolarisation_activated_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_f_Na" variable_2="I_f_Na"/>
<map_variables variable_1="i_f_K" variable_2="I_f_K"/>
</connection>
<connection>
<map_components component_1="pandit_background_currents" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_B_Na" variable_2="I_B_Na"/>
<map_variables variable_1="i_B_K" variable_2="I_B_K"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_potassium_pump" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_NaK" variable_2="I_NaK"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="pandit_standard_ionic_concentrations"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="pandit_standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="pandit_inward_rectifier" component_2="pandit_standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_potassium_pump" component_2="pandit_standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="pandit_steady_state_outward_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="pandit_inward_rectifier"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="pandit_hyperpolarisation_activated_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="pandit_background_currents"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="pandit_hyperpolarisation_activated_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="pandit_background_currents"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="V_myo_uL" variable_2="V_myo_uL"/>
<map_variables variable_1="V_SR_uL" variable_2="V_SR_uL"/>
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="hinch_CaRU"/>
<map_variables variable_1="V_myo" variable_2="V_myo"/>
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="convert_hinch"/>
<map_variables variable_1="V_myo_uL" variable_2="V_myo_uL"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="convert_hinch"/>
<map_variables variable_1="I_LCC" variable_2="hinch_I_LCC"/>
<map_variables variable_1="I_RyR" variable_2="hinch_I_RyR"/>
</connection>
<connection>
<map_components component_1="hinch_Na_Ca_Exchanger" component_2="convert_hinch"/>
<map_variables variable_1="I_NaCa" variable_2="hinch_I_NaCa"/>
</connection>
<connection>
<map_components component_1="hinch_Sarcolemmal_Ca_pump" component_2="convert_hinch"/>
<map_variables variable_1="I_pCa" variable_2="hinch_I_pCa"/>
</connection>
<connection>
<map_components component_1="hinch_Background_Ca_current" component_2="convert_hinch"/>
<map_variables variable_1="I_CaB" variable_2="hinch_I_CaB"/>
</connection>
<connection>
<map_components component_1="hinch_calmodulin_Ca_buffer" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="beta_CMDN" variable_2="beta_CMDN"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="convert_hinch" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="I_LCC" variable_2="I_LCC"/>
<map_variables variable_1="I_RyR" variable_2="I_RyR"/>
<map_variables variable_1="I_NaCa" variable_2="I_NaCa"/>
<map_variables variable_1="I_pCa" variable_2="I_pCa"/>
<map_variables variable_1="I_CaB" variable_2="I_CaB"/>
</connection>
<connection>
<map_components component_1="convert_hinch" component_2="membrane"/>
<map_variables variable_1="I_NaCa" variable_2="I_NaCa"/>
<map_variables variable_1="I_LCC" variable_2="I_LCC"/>
<map_variables variable_1="I_pCa" variable_2="I_pCa"/>
<map_variables variable_1="I_CaB" variable_2="I_CaB"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
</connection>
<connection>
<map_components component_1="hinch_Na_Ca_Exchanger" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="hinch_SERCA" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="I_SERCA" variable_2="I_SERCA"/>
</connection>
<connection>
<map_components component_1="hinch_Sarcolemmal_Ca_pump" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="hinch_Background_Ca_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="hinch_SR_Ca_leak_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="I_SR" variable_2="I_SR"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="pandit_standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="hinch_Na_Ca_Exchanger" component_2="pandit_standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="hinch_Background_Ca_current" component_2="pandit_standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_sodium_current" component_2="sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_r_gate"/>
<map_variables variable_1="r" variable_2="r"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_gate"/>
<map_variables variable_1="s" variable_2="s"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_slow_gate"/>
<map_variables variable_1="s_slow" variable_2="s_slow"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_steady_state_outward_K_current" component_2="steady_state_outward_K_current_r_ss_gate"/>
<map_variables variable_1="r_ss" variable_2="r_ss"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_steady_state_outward_K_current" component_2="steady_state_outward_K_current_s_ss_gate"/>
<map_variables variable_1="s_ss" variable_2="s_ss"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="pandit_hyperpolarisation_activated_current" component_2="hyperpolarisation_activated_current_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="CaRU_reduced_states"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="LCC_and_RyR_fluxes"/>
<map_variables variable_1="g_D" variable_2="g_D"/>
<map_variables variable_1="J_R" variable_2="J_R"/>
<map_variables variable_1="J_L" variable_2="J_L"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="CaRU_Transitions"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="CaRU_states"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<map_variables variable_1="alpha_m" variable_2="alpha_m"/>
<map_variables variable_1="beta_pcc" variable_2="beta_pcc"/>
<map_variables variable_1="beta_poc" variable_2="beta_poc"/>
<map_variables variable_1="beta_m" variable_2="beta_m"/>
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="RyR_current"/>
<map_variables variable_1="beta_pcc" variable_2="beta_pcc"/>
<map_variables variable_1="beta_m" variable_2="beta_m"/>
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="LCC_current"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<map_variables variable_1="alpha_m" variable_2="alpha_m"/>
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="RyR_current"/>
<map_variables variable_1="y_oo" variable_2="y_oo"/>
<map_variables variable_1="y_co" variable_2="y_co"/>
<map_variables variable_1="y_oc" variable_2="y_oc"/>
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="LCC_current"/>
<map_variables variable_1="y_oo" variable_2="y_oo"/>
<map_variables variable_1="y_oc" variable_2="y_oc"/>
</connection>
<connection>
<map_components component_1="LCC_and_RyR_fluxes" component_2="RyR_current"/>
<map_variables variable_1="J_Roo" variable_2="J_Roo"/>
<map_variables variable_1="J_Rco" variable_2="J_Rco"/>
</connection>
<connection>
<map_components component_1="LCC_and_RyR_fluxes" component_2="LCC_current"/>
<map_variables variable_1="J_Loo" variable_2="J_Loo"/>
<map_variables variable_1="J_Loc" variable_2="J_Loc"/>
</connection>
<connection>
<map_components component_1="CaRU_reduced_states" component_2="RyR_current"/>
<map_variables variable_1="z_1" variable_2="z_1"/>
<map_variables variable_1="z_3" variable_2="z_3"/>
</connection>
<connection>
<map_components component_1="CaRU_reduced_states" component_2="LCC_current"/>
<map_variables variable_1="z_1" variable_2="z_1"/>
<map_variables variable_1="z_2" variable_2="z_2"/>
</connection>
<connection>
<map_components component_1="DS_Calcium_Concentrations" component_2="CaRU_Transitions"/>
<map_variables variable_1="C_oc" variable_2="C_oc"/>
<map_variables variable_1="C_co" variable_2="C_co"/>
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="CaRU_reduced_states"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<map_variables variable_1="alpha_m" variable_2="alpha_m"/>
<map_variables variable_1="beta_pcc" variable_2="beta_pcc"/>
<map_variables variable_1="beta_m" variable_2="beta_m"/>
<map_variables variable_1="epsilon_pco" variable_2="epsilon_pco"/>
<map_variables variable_1="epsilon_pcc" variable_2="epsilon_pcc"/>
<map_variables variable_1="epsilon_m" variable_2="epsilon_m"/>
<map_variables variable_1="mu_poc" variable_2="mu_poc"/>
<map_variables variable_1="mu_pcc" variable_2="mu_pcc"/>
<map_variables variable_1="mu_moc" variable_2="mu_moc"/>
<map_variables variable_1="mu_mcc" variable_2="mu_mcc"/>
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="CaRU_reduced_states"/>
<map_variables variable_1="y_oc" variable_2="y_oc"/>
<map_variables variable_1="y_cc" variable_2="y_cc"/>
<map_variables variable_1="y_co" variable_2="y_co"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="DS_Calcium_Concentrations"/>
<map_variables variable_1="g_D" variable_2="g_D"/>
<map_variables variable_1="J_R" variable_2="J_R"/>
<map_variables variable_1="J_L" variable_2="J_L"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="RyR_current"/>
<map_variables variable_1="V_myo" variable_2="V_myo"/>
<map_variables variable_1="N" variable_2="N"/>
<map_variables variable_1="I_RyR" variable_2="I_RyR"/>
</connection>
<connection>
<map_components component_1="hinch_CaRU" component_2="LCC_current"/>
<map_variables variable_1="V_myo" variable_2="V_myo"/>
<map_variables variable_1="N" variable_2="N"/>
<map_variables variable_1="I_LCC" variable_2="I_LCC"/>
</connection>
<connection>
<map_components component_1="niederer_tropomyosin" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="niederer_Myofilaments" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="niederer_Cross_Bridges" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="niederer_troponin" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_TRPN_Max" variable_2="Ca_TRPN_Max"/>
<map_variables variable_1="TRPN" variable_2="TRPN"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="I_TRPN" variable_2="I_TRPN"/>
</connection>
<connection>
<map_components component_1="niederer_tropomyosin" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_b" variable_2="Ca_b"/>
</connection>
<connection>
<map_components component_1="niederer_length_independent_tension" component_2="niederer_tropomyosin"/>
<map_variables variable_1="z" variable_2="z"/>
<map_variables variable_1="z_max" variable_2="z_max"/>
</connection>
<connection>
<map_components component_1="niederer_troponin" component_2="niederer_Cross_Bridges"/>
<map_variables variable_1="Tension" variable_2="Tension"/>
</connection>
<connection>
<map_components component_1="niederer_troponin" component_2="niederer_length_independent_tension"/>
<map_variables variable_1="T_ref" variable_2="T_ref"/>
</connection>
<connection>
<map_components component_1="niederer_tropomyosin" component_2="niederer_troponin"/>
<map_variables variable_1="k_on" variable_2="k_on"/>
<map_variables variable_1="k_Ref_off" variable_2="k_Ref_off"/>
<map_variables variable_1="gamma_trpn" variable_2="gamma_trpn"/>
<map_variables variable_1="Ca_TRPN_Max" variable_2="Ca_TRPN_Max"/>
</connection>
<connection>
<map_components component_1="niederer_tropomyosin" component_2="niederer_filament_overlap"/>
<map_variables variable_1="beta_0" variable_2="beta_0"/>
</connection>
<connection>
<map_components component_1="niederer_tropomyosin" component_2="niederer_Myofilaments"/>
<map_variables variable_1="lambda" variable_2="lambda"/>
</connection>
<connection>
<map_components component_1="niederer_filament_overlap" component_2="niederer_Myofilaments"/>
<map_variables variable_1="lambda" variable_2="lambda"/>
</connection>
<connection>
<map_components component_1="niederer_isometric_tension" component_2="niederer_length_independent_tension"/>
<map_variables variable_1="T_Base" variable_2="T_Base"/>
</connection>
<connection>
<map_components component_1="niederer_isometric_tension" component_2="niederer_filament_overlap"/>
<map_variables variable_1="overlap" variable_2="overlap"/>
</connection>
<connection>
<map_components component_1="niederer_Cross_Bridges" component_2="niederer_Myofilaments"/>
<map_variables variable_1="dExtensionRatiodt" variable_2="dExtensionRatiodt"/>
</connection>
<connection>
<map_components component_1="niederer_Cross_Bridges" component_2="niederer_isometric_tension"/>
<map_variables variable_1="T_0" variable_2="T_0"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Seq rdf:about="rdf:#0a540d49-9617-4b05-9341-8a7f17f683b3">
<rdf:li rdf:resource="rdf:#1f27c209-2bce-4b3a-be80-c363512900f9"/>
<rdf:li rdf:resource="rdf:#86547e45-c5f4-4929-8993-d95fc2b621d2"/>
<rdf:li rdf:resource="rdf:#917da876-d567-45f1-b4c1-b340a3d648b2"/>
<rdf:li rdf:resource="rdf:#29081242-31b1-4b24-ad1d-eb9f01ddc28d"/>
<rdf:li rdf:resource="rdf:#b26a1772-6d22-4107-8cee-ef6dec68e161"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#f21899cf-1bbb-4a30-a8ff-97742d0e80f5">
<vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#40f32e3c-a471-4581-8b87-734a2319d764"/>
<vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#ad0325ea-d8e4-40b6-9759-f182c7432669"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#59cdee69-09af-4c7c-bd3e-d49982596429"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#65988d73-d3a5-4cce-ba08-4d43789cea4c">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Jonna</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Terkildsen</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">R</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6ac7103b-c16d-475d-a345-fc7279edaa17">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lawson</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#84adde57-db78-466a-97e6-9671c7d199a8">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Edmund</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Crampin</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d4a45d7d-9362-4575-92bc-587671e78fcc">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#2516a582-bc38-4e4c-a67e-164902ff8929"/>
<rdf:value/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$DtFl5">
<ns7:boundIntervals xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$EtFl5"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1f27c209-2bce-4b3a-be80-c363512900f9">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#65988d73-d3a5-4cce-ba08-4d43789cea4c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d864f300-bb41-438b-a374-22885e9a74e3">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#6ac7103b-c16d-475d-a345-fc7279edaa17"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2c7e2db3-8c58-442c-b51b-6fc6d8be0003">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Experimental Physiology</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#86547e45-c5f4-4929-8993-d95fc2b621d2">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#e49f696e-26ed-4881-90ca-867d63100bae"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#39d628a5-b6eb-46b5-bacc-7e550717e71e">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2008-07-00 00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$FtFl5">
<ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">5000</ns7:endingValue>
<ns7:nonstandard-pointDensity xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">10000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">0.1</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="#terkildsen_2008">
<ns7:simulation xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$ekohZ3"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#fbb24ccf-610d-44f1-a665-dd284da2e47f"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>cardiac</rdf:li>
<rdf:li>electrophysiology</rdf:li>
<rdf:li>rat</rdf:li>
<rdf:li>excitation-contraction coupling</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<cmeta:comment rdf:resource="rdf:#d4a45d7d-9362-4575-92bc-587671e78fcc"/>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher xmlns:dc="http://purl.org/dc/elements/1.1/">The University of Auckland, Auckland Bioengineering Institute</dc:publisher>
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#f21899cf-1bbb-4a30-a8ff-97742d0e80f5"/>
<ns7:simulation xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$DtFl5"/>
<cmeta:comment rdf:resource="rdf:#b399eb56-4c31-4dcb-9ed9-0ffa50d99506"/>
<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#c8c45897-f27e-41c8-bdf4-fdad5311d2c3"/>
<cmeta:modification rdf:resource="rdf:#01b1f3a9-8550-4c31-972a-2233ea5606b5"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$gkohZ3">
<ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">5000</ns7:endingValue>
<ns7:nonstandard-pointDensity xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">10000</ns7:nonstandard-pointDensity>
<ns7:maximumStepSize xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">0.1</ns7:maximumStepSize>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$fkohZ3">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$gkohZ3"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2516a582-bc38-4e4c-a67e-164902ff8929">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#917da876-d567-45f1-b4c1-b340a3d648b2">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#84adde57-db78-466a-97e6-9671c7d199a8"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9ba8480f-fd11-476d-a01a-fef741bf1259">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b399eb56-4c31-4dcb-9ed9-0ffa50d99506">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#9ba8480f-fd11-476d-a01a-fef741bf1259"/>
<rdf:value>Since this is the exact same model encoding which was used to create the results presented in the paper, this CellML model is known to accurately represent the published article.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e49f696e-26ed-4881-90ca-867d63100bae">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Steven</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Niederer</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#29081242-31b1-4b24-ad1d-eb9f01ddc28d">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#afbd09d3-ee03-467d-88b1-4f9dfae56348"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#afbd09d3-ee03-467d-88b1-4f9dfae56348">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Peter</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Hunter</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$ekohZ3">
<ns7:boundIntervals xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$fkohZ3"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b26a1772-6d22-4107-8cee-ef6dec68e161">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#cc93efe7-f009-4939-91ea-8c40d10419d2"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$EtFl5">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$FtFl5"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b92ac5a4-36f4-4746-b65b-68ec42ad7b53">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#0a540d49-9617-4b05-9341-8a7f17f683b3"/>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction</dc:title>
<bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">93</bqs:volume>
<bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">919</bqs:first_page>
<bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#2c7e2db3-8c58-442c-b51b-6fc6d8be0003"/>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#39d628a5-b6eb-46b5-bacc-7e550717e71e"/>
<bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">929</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cc93efe7-f009-4939-91ea-8c40d10419d2">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Nicolas</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Smith</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">P</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#18e2d24c-8f28-4fb3-84b1-d0125c52598a">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2008-08-06T12:44:02+12:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#40f32e3c-a471-4581-8b87-734a2319d764">
<vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The University of Auckland</vCard:Orgname>
<vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Auckland Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#01b1f3a9-8550-4c31-972a-2233ea5606b5">
<dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#18e2d24c-8f28-4fb3-84b1-d0125c52598a"/>
<rdf:value>Added CellML 1.0 model to version 01's documentation.
Added some cmeta:ids to variables</rdf:value>
<cmeta:modifier rdf:resource="rdf:#d864f300-bb41-438b-a374-22885e9a74e3"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c8c45897-f27e-41c8-bdf4-fdad5311d2c3">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2008-07-15T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ad0325ea-d8e4-40b6-9759-f182c7432669">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>j.terkildsen@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#59cdee69-09af-4c7c-bd3e-d49982596429">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Jonna</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Terkildsen</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#fbb24ccf-610d-44f1-a665-dd284da2e47f">
<bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">18344258</bqs:Pubmed_id>
<bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#b92ac5a4-36f4-4746-b65b-68ec42ad7b53"/>
</rdf:Description>
</rdf:RDF>
</model>