Location: Surkis, Peskin, Tranchina, Leonard, 1998 @ 0a2d4d698cf7 / surkis_peskin_tranchina_leonard_1998.cellml

Author:
Hanne <Hanne@hanne-nielsens-macbook.local>
Date:
2009-12-14 16:57:51+13:00
Desc:
Added images in ai and svg format, removed non pub med reference
Permanent Source URI:
https://models.physiomeproject.org/workspace/surkis_peskin_tranchina_leonard_1998/rawfile/0a2d4d698cf7a7ab80c4f7637d5989204624f727/surkis_peskin_tranchina_leonard_1998.cellml

<?xml version='1.0' encoding='utf-8'?>
<!--  FILE :  surkis_model_1998.xml

CREATED :  5th December 2002

LAST MODIFIED : 9th September 2003

AUTHOR :  Catherine Lloyd
          Bioengineering Institute
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification.

DESCRIPTION :  This file contains a CellML description of Surkis et al's 1998 mathematical model of the cable properties of laterodorsal tegmental neurons. 

CHANGES:  
  09/04/2003 - AAC - Added publication date information.  
  09/09/2003 - AAC - Changed units of Gm in membrane component from 
                     microS_per_cm2.  
  
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="surkis_peskin_tranchina_leonard_1998_version01" name="surkis_peskin_tranchina_leonard_1998_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Modelling the Membrane Behaviour of LDT Neurons</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model contains partial differentials and as such can not currently be solved by existing CellML tools.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
The laterodorsal tegmental nucleus (LDT) is located at the junction of the pons and the midbrain - regions of the brain.  The neurons from this area are thought to play an essential role in the generation of the electroencephalographic (EEG)-desyncronised states of waking and rapid eye movement (REM) sleep.  The neurons are heterogeneous, displaying different firing rates in waking, slow-wave (SW), and REM sleep.  Different membrane properties, cell morphology and synaptic input signals are thought to underlie this firing heterogeneity.    </para>

<para>
In order to evaluate the relative importance of these factors, Surkis <emphasis>et al.</emphasis> analysed the cable properties of the principal LDT neurons. (the complete original paper reference is cited below).  Data from these experiments were then used to produce a biologically realistic mathematical model of these cells.  Their study involved developing two cell models, one in which the membrane was assumed to be passive, and one in which it was assumed that voltage-dependent conductances were contributing to cell behaviour.  They found that only the active membrane model could adequately describe the behaviour of the LDT cells, and it is this model which is described below.  
</para>

<para>
Recovery of Cable Properties Through Active and Passive Modeling of Subthreshold Membrane Responses From Laterodorsal Tegmental Neurons, A. Surkis, C.S. Peskin, D. Tranchina, and C.S. Leonard, 1998,<emphasis>Journal of Neurophysiology</emphasis>, 80, 2593-2607. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9819266&amp;dopt=Abstract">PubMed ID: 9819266</ulink>  
</para>

<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell schematic for the model</title>
    </objectinfo>
    <imagedata fileref="surkis_1998.png"/>
  </imageobject>
</mediaobject>
<caption>Schematic diagram of the voltage-dependent conductances across the plasma membrane of a LDT neuron.  <emphasis>I<subscript>A</subscript>
            </emphasis> represents a transient subthreshold K<superscript>+</superscript> current.  <emphasis>I<subscript>H</subscript>
            </emphasis> is a cation current that has a depolarising influence and it is activated on hyperpolarisation of the cell.</caption>
</informalfigure>

</sect1>
</article>
</documentation>
  
  
  <!--
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  -->
  
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