Location: Saucerman, Brunton, Michailova, Mcculloch, 2003 @ 23d9226364da / saucerman_brunton_michailova_mcculloch_2003.cellml

Author:
Hanne <Hanne@hanne-nielsens-macbook.local>
Date:
2010-09-01 12:03:24+12:00
Desc:
Added arrows to ai and svg
Permanent Source URI:
https://models.physiomeproject.org/workspace/saucerman_brunton_michailova_mcculloch_2003/rawfile/23d9226364daaa1fac2d0f3cb43f9ea9786e626e/saucerman_brunton_michailova_mcculloch_2003.cellml

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This CellML file was generated on 21/10/2009 at 4:24:32 at p.m. using:

COR (0.9.31.1319)
Copyright 2002-2009 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
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                <title>Modelling Beta-adrenergic Control of Cardiac Myocyte Contractility in Silico</title>
                <author>
                    <firstname>Catherine</firstname>
                    <surname>Lloyd</surname>
                    <affiliation>
                        <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
                    </affiliation>
                </author>
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            <section id="sec_status">
                <title>Model Status</title>
                <para>
        This CellML version of the Saucerman and McCulloch 2003 model is a translation of Jeff Saucerman's original MATLAB code.  It doesn't run in COR due to the presence of differential algebraic equations (DAEs).  Use of additional RDF intial condition hints allow this version to run in the head revision of OpenCell using IDA as the solver. Exporting the CellML to MATLAB using OpenCell and then running the MATLAB output also works. It recreates the results of the original published model. Units require further correction and we are continuting to work on this model.
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            </section>
            <sect1 id="sec_structure">
                <title>Model Structure</title>
                <para>
ABSTRACT: The beta-adrenergic signaling pathway regulates cardiac myocyte contractility through a combination of feedforward and feedback mechanisms. We used systems analysis to investigate how the components and topology of this signaling network permit neurohormonal control of excitation-contraction coupling in the rat ventricular myocyte. A kinetic model integrating beta-adrenergic signaling with excitation-contraction coupling was formulated, and each subsystem was validated with independent biochemical and physiological measurements. Model analysis was used to investigate quantitatively the effects of specific molecular perturbations. 3-Fold overexpression of adenylyl cyclase in the model allowed an 85% higher rate of cyclic AMP synthesis than an equivalent overexpression of beta 1-adrenergic receptor, and manipulating the affinity of Gs alpha for adenylyl cyclase was a more potent regulator of cyclic AMP production. The model predicted that less than 40% of adenylyl cyclase molecules may be stimulated under maximal receptor activation, and an experimental protocol is suggested for validating this prediction. The model also predicted that the endogenous heat-stable protein kinase inhibitor may enhance basal cyclic AMP buffering by 68% and increasing the apparent Hill coefficient of protein kinase A activation from 1.0 to 2.0. Finally, phosphorylation of the L-type calcium channel and phospholamban were found sufficient to predict the dominant changes in myocyte contractility, including a 2.6x increase in systolic calcium (inotropy) and a 28% decrease in calcium half-relaxation time (lusitropy). By performing systems analysis, the consequences of molecular perturbations in the beta-adrenergic signaling network may be understood within the context of integrative cellular physiology.
                </para>

                <para>
The original paper reference is cited below:
                </para>
                <para>Modeling beta-adrenergic control of cardiac myocyte contractility <emphasis>in silico</emphasis>
                                       , Jeffrey J. Saucerman, Laurence L. Brunton, Anushka P. Michailova, and Andrew D. McCulloch, 2003, <emphasis>Journal of Biological Chemistry</emphasis>, 48, 47997-48003. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12972422&amp;dopt=Abstract">PubMed ID: 12972422</ulink>
                </para>

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                            <objectinfo>
                                <title>cell diagram</title>
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                    <caption>Schematic diagram of the integrated model components, including the beta-adrenergic network, calcium handling, and the electrophysiology of the rat ventricular myocyte.</caption>
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    <units name="mM">
        <unit prefix="milli" units="mole"/>
        <unit exponent="-1" units="liter"/>
    </units>
    <units name="uM">
        <unit prefix="micro" units="mole"/>
        <unit exponent="-1" units="liter"/>
    </units>
    <units name="per_sec">
        <unit exponent="-1" units="second"/>
    </units>
    <units name="mM_per_sec">
        <unit units="mM"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="uM_per_sec">
        <unit units="uM"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="per_mM_per_sec">
        <unit exponent="-1" units="mM"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="per_uM_per_sec">
        <unit exponent="-1" units="uM"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="uL">
        <unit prefix="micro" units="liter"/>
    </units>
    <units name="cm_per_sec">
        <unit prefix="centi" units="meter"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="cm2">
        <unit exponent="2" prefix="centi" units="meter"/>
    </units>
    <units name="mV">
        <unit prefix="milli" units="volt"/>
    </units>
    <units name="per_mV">
        <unit exponent="-1" units="mV"/>
    </units>
    <units name="mV_per_sec">
        <unit prefix="milli" units="volt"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="mS_per_uF">
        <unit prefix="milli" units="siemens"/>
        <unit exponent="-1" prefix="micro" units="farad"/>
    </units>
    <units name="uA_per_uF">
        <unit prefix="micro" units="ampere"/>
        <unit exponent="-1" prefix="micro" units="farad"/>
    </units>
    <units name="joules_per_mole_kelvin">
        <unit units="joule"/>
        <unit exponent="-1" units="mole"/>
        <unit exponent="-1" units="kelvin"/>
    </units>
    <units name="coulombs_per_mole">
        <unit units="coulomb"/>
        <unit exponent="-1" units="mole"/>
    </units>
    <units name="unknown">
        <unit units="dimensionless"/>
    </units>
    <component name="environment">
        <variable name="time" public_interface="out" units="second"/>
        <variable initial_value="0" name="protocol" public_interface="out" units="dimensionless"/>
    </component>
    <component name="b1_AR_Gs_parameters">
        <variable initial_value="1" name="L_totmax" public_interface="out" units="uM"/>
        <variable initial_value="0.0132" name="sum_b1_AR" public_interface="out" units="uM"/>
        <variable initial_value="3.83" name="Gs_tot" public_interface="out" units="uM"/>
        <variable initial_value="0.285" name="Kl" public_interface="out" units="uM"/>
        <variable initial_value="0.062" name="Kr" public_interface="out" units="uM"/>
        <variable initial_value="33" name="Kc" public_interface="out" units="uM"/>
        <variable initial_value="1.1e-3" name="k_bar_kp" public_interface="out" units="per_sec"/>
        <variable initial_value="2.2e-3" name="k_bar_km" public_interface="out" units="per_sec"/>
        <variable initial_value="3.6e-3" name="k_p_kap" public_interface="out" units="per_uM_per_sec"/>
        <variable initial_value="2.2e-3" name="k_p_kam" public_interface="out" units="per_sec"/>
        <variable initial_value="16" name="k_g_act" public_interface="out" units="per_sec"/>
        <variable initial_value="0.8" name="k_hyd" public_interface="out" units="per_sec"/>
        <variable initial_value="1.21e3" name="k_reassoc" public_interface="out" units="per_uM_per_sec"/>
    </component>
    <component name="cAMP_parameters">
        <variable initial_value="49.7e-3" name="AC_tot" public_interface="out" units="uM"/>
        <variable initial_value="5e3" name="ATP" public_interface="out" units="uM"/>
        <variable initial_value="38.9e-3" name="PDE_tot" public_interface="out" units="uM"/>
        <variable initial_value="0" name="IBMX_tot" public_interface="out" units="uM"/>
        <variable initial_value="0" name="Fsk_tot" public_interface="out" units="uM"/>
        <variable initial_value="0.2" name="k_ac_basal" public_interface="out" units="per_sec"/>
        <variable initial_value="8.5" name="k_ac_gsa" public_interface="out" units="per_sec"/>
        <variable initial_value="7.3" name="k_ac_fsk" public_interface="out" units="per_sec"/>
        <variable initial_value="5" name="k_pde" public_interface="out" units="per_sec"/>
        <variable initial_value="1.03e3" name="Km_basal" public_interface="out" units="uM"/>
        <variable initial_value="315" name="Km_gsa" public_interface="out" units="uM"/>
        <variable initial_value="860" name="Km_fsk" public_interface="out" units="uM"/>
        <variable initial_value="1.3" name="Km_pde" public_interface="out" units="uM"/>
        <variable initial_value="0.4" name="K_gsa" public_interface="out" units="uM"/>
        <variable initial_value="44" name="K_fsk" public_interface="out" units="uM"/>
        <variable initial_value="30" name="Ki_ibmx" public_interface="out" units="uM"/>
    </component>
    <component name="PKA_parameters">
        <variable initial_value="0.59" name="PKAI_tot" public_interface="out" units="uM"/>
        <variable initial_value="0.025" name="PKAII_tot" public_interface="out" units="uM"/>
        <variable initial_value="0.18" name="PKI_tot" public_interface="out" units="uM"/>
        <variable initial_value="9.14" name="K_a" public_interface="out" units="uM"/>
        <variable initial_value="1.64" name="K_b" public_interface="out" units="uM"/>
        <variable initial_value="4.375" name="K_d" public_interface="out" units="uM"/>
        <variable initial_value="0.2e-3" name="Ki_pki" public_interface="out" units="uM"/>
    </component>
    <component name="PLB_parameters">
        <variable initial_value="106" name="PLB_tot" public_interface="out" units="uM"/>
        <variable initial_value="0.89" name="PP1_tot" public_interface="out" units="uM"/>
        <variable initial_value="0.3" name="Inhib1_tot" public_interface="out" units="uM"/>
        <variable initial_value="54" name="k_pka_plb" public_interface="out" units="per_sec"/>
        <variable initial_value="21" name="Km_pka_plb" public_interface="out" units="uM"/>
        <variable initial_value="8.5" name="k_pp1_plb" public_interface="out" units="per_sec"/>
        <variable initial_value="7" name="Km_pp1_plb" public_interface="out" units="uM"/>
        <variable initial_value="60" name="k_pka_i1" public_interface="out" units="per_sec"/>
        <variable initial_value="1" name="Km_pka_i1" public_interface="out" units="uM"/>
        <variable initial_value="14" name="Vmax_pp2a_i1" public_interface="out" units="uM_per_sec"/>
        <variable initial_value="1" name="Km_pp2a_i1" public_interface="out" units="uM"/>
        <variable initial_value="1e-3" name="Ki_inhib1" public_interface="out" units="uM"/>
    </component>
    <component name="LCC_parameters">
        <variable initial_value="10" name="epsilon" public_interface="out" units="dimensionless"/>
        <variable initial_value="25e-3" name="LCC_tot" public_interface="out" units="uM"/>
        <variable initial_value="25e-3" name="PP1_lcc_tot" public_interface="out" units="uM"/>
        <variable initial_value="25e-3" name="PP2A_lcc_tot" public_interface="out" units="uM"/>
        <variable initial_value="54" name="k_pka_lcc" public_interface="out" units="per_sec"/>
        <variable initial_value="21" name="Km_pka_lcc" public_interface="out" units="uM"/>
        <variable initial_value="8.52" name="k_pp1_lcc" public_interface="out" units="per_sec"/>
        <variable initial_value="3" name="Km_pp1_lcc" public_interface="out" units="uM"/>
        <variable initial_value="10.1" name="k_pp2a_lcc" public_interface="out" units="per_sec"/>
        <variable initial_value="3" name="Km_pp2a_lcc" public_interface="out" units="uM"/>
    </component>
    <component name="EC_Coupling_Parameters">
        <variable initial_value="20.8e-6" name="V_myo" public_interface="out" units="uL"/>
        <variable initial_value="9.88e-7" name="V_nsr" public_interface="out" units="uL"/>
        <variable initial_value="9.3e-8" name="V_jsr" public_interface="out" units="uL"/>
        <variable initial_value="1.534e-4" name="A_Cap" public_interface="out" units="cm2"/>
        <variable initial_value="310" name="Temp" public_interface="out" units="kelvin"/>
        <variable initial_value="140" name="Na_ext" public_interface="out" units="mM"/>
        <variable initial_value="5.4" name="K_ext" public_interface="out" units="mM"/>
        <variable initial_value="1.8" name="Ca_ext" public_interface="out" units="mM"/>
        <variable initial_value="8" name="G_Na" public_interface="out" units="mS_per_uF"/>
        <variable initial_value="0.35" name="G_to" public_interface="out" units="mS_per_uF"/>
        <variable initial_value="0.07" name="G_ss" public_interface="out" units="mS_per_uF"/>
        <variable initial_value="0.24" name="G_Ki_bar" public_interface="out" units="mS_per_uF"/>
        <variable initial_value="0.008" name="G_Kp" public_interface="out" units="mS_per_uF"/>
        <variable initial_value="300" name="f" public_interface="out" units="per_sec"/>
        <variable initial_value="2e3" name="g" public_interface="out" units="per_sec"/>
        <variable initial_value="5187.5" name="gamma_o" public_interface="out" units="per_mM_per_sec"/>
        <variable initial_value="10" name="omega" public_interface="out" units="per_sec"/>
        <variable initial_value="1.7469e-8" name="p_Ca" public_interface="out" units="cm_per_sec"/>
        <variable initial_value="3.234e-11" name="p_K" public_interface="out" units="cm_per_sec"/>
        <variable initial_value="3e5" name="N_lcc" public_interface="out" units="dimensionless"/>
        <variable initial_value="-0.458" name="I_Ca05" public_interface="out" units="uA_per_uF"/>
        <variable initial_value="1483" name="k_NaCa" public_interface="out" units="uA_per_uF"/>
        <variable initial_value="87.5" name="Km_Na" public_interface="out" units="mM"/>
        <variable initial_value="1.38" name="Km_Ca" public_interface="out" units="mM"/>
        <variable initial_value="0.1" name="k_sat" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.35" name="eta" public_interface="out" units="dimensionless"/>
        <variable initial_value="1.1" name="I_bar_NaK" public_interface="out" units="uA_per_uF"/>
        <variable initial_value="10" name="Km_Nai" public_interface="out" units="mM"/>
        <variable initial_value="1.5" name="Km_Ko" public_interface="out" units="mM"/>
        <variable initial_value="1.15" name="I_bar_PCa" public_interface="out" units="uA_per_uF"/>
        <variable initial_value="0.5e-3" name="Km_PCa" public_interface="out" units="mM"/>
        <variable initial_value="2.8e-3" name="G_CaB" public_interface="out" units="uA_per_uF"/>
        <variable initial_value="1.18e-3" name="G_NaB" public_interface="out" units="uA_per_uF"/>
        <variable initial_value="0" name="Pns" public_interface="out" units="dimensionless"/>
        <variable initial_value="1.2e-3" name="Km_NS" public_interface="out" units="mM"/>
        <variable initial_value="4.7" name="I_up_bar" public_interface="out" units="mM_per_sec"/>
        <variable initial_value="3e-4" name="Km_up0" public_interface="out" units="mM"/>
        <variable initial_value="15" name="NSR_bar" public_interface="out" units="mM"/>
        <variable initial_value="2e-3" name="tau_on" public_interface="out" units="second"/>
        <variable initial_value="2e-3" name="tau_off" public_interface="out" units="second"/>
        <variable initial_value="60e3" name="G_max_rel" public_interface="out" units="mM_per_sec"/>
        <variable initial_value="0.18e-3" name="d_Cai_th" public_interface="out" units="mM"/>
        <variable initial_value="0.8e-3" name="Km_rel" public_interface="out" units="mM"/>
        <variable initial_value="8.75" name="CSQN_th" public_interface="out" units="mM"/>
        <variable initial_value="15" name="CSQN_bar" public_interface="out" units="mM"/>
        <variable initial_value="0.8" name="Km_CSQN" public_interface="out" units="mM"/>
        <variable initial_value="5.7e-4" name="tau_tr" public_interface="out" units="second"/>
        <variable initial_value="0.07" name="TRPN_bar" public_interface="out" units="mM"/>
        <variable initial_value="0.05" name="CMDN_bar" public_interface="out" units="mM"/>
        <variable initial_value="0.07" name="INDO_bar" public_interface="out" units="mM"/>
        <variable initial_value="0.5128e-3" name="Km_TRPN" public_interface="out" units="mM"/>
        <variable initial_value="2.38e-3" name="Km_CMDN" public_interface="out" units="mM"/>
        <variable initial_value="8.44e-4" name="Km_INDO" public_interface="out" units="mM"/>
    </component>
    <component name="b1_AR_module">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="L_totmax" public_interface="in" units="uM"/>
        <variable name="sum_b1_AR" public_interface="in" units="uM"/>
        <variable name="Gs_tot" public_interface="in" units="uM"/>
        <variable name="Kl" public_interface="in" units="uM"/>
        <variable name="Kr" public_interface="in" units="uM"/>
        <variable name="Kc" public_interface="in" units="uM"/>
        <variable name="k_bar_kp" public_interface="in" units="per_sec"/>
        <variable name="k_bar_km" public_interface="in" units="per_sec"/>
        <variable name="k_p_kap" public_interface="in" units="per_uM_per_sec"/>
        <variable name="k_p_kam" public_interface="in" units="per_sec"/>
        <variable name="k_g_act" public_interface="in" units="per_sec"/>
        <variable name="k_hyd" public_interface="in" units="per_sec"/>
        <variable name="k_reassoc" public_interface="in" units="per_uM_per_sec"/>
        <variable cmeta:id="LR" name="LR" public_interface="out" units="uM"/>
        <variable cmeta:id="LRG" name="LRG" public_interface="out" units="uM"/>
        <variable cmeta:id="RG" name="RG" public_interface="out" units="uM"/>
        <variable cmeta:id="BARK_DESENS" name="BARK_DESENS" units="uM_per_sec"/>
        <variable name="BARK_RESENS" units="uM_per_sec"/>
        <variable cmeta:id="PKA_DESENS" name="PKA_DESENS" units="uM_per_sec"/>
        <variable name="PKA_RESENS" units="uM_per_sec"/>
        <variable cmeta:id="G_ACT" name="G_ACT" units="uM_per_sec"/>
        <variable name="HYD" units="uM_per_sec"/>
        <variable name="REASSOC" units="per_sec"/>
        <variable cmeta:id="L" name="L" public_interface="out" units="uM"/>
        <variable cmeta:id="R" name="R" public_interface="out" units="uM"/>
        <variable cmeta:id="Gs" name="Gs" public_interface="out" units="uM"/>
        <variable initial_value="0.01205" name="b1_AR_tot" public_interface="out" units="uM"/>
        <variable initial_value="0" name="b1_AR_d" public_interface="out" units="uM"/>
        <variable initial_value="1.154e-3" name="b1_AR_p" public_interface="out" units="uM"/>
        <variable initial_value="0.02505" name="Gs_agtp_tot" public_interface="out" units="uM"/>
        <variable initial_value="6.446e-4" name="Gs_agdp" public_interface="out" units="uM"/>
        <variable initial_value="0.02569" name="Gs_bg" public_interface="out" units="uM"/>
        <variable name="PKAC_I" public_interface="in" units="uM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>LR</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>L</ci>
                        <ci>R</ci>
                    </apply>
                    <ci>Kl</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>LRG</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>LR</ci>
                        <ci>Gs</ci>
                    </apply>
                    <ci>Kr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>RG</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>Gs</ci>
                    </apply>
                    <ci>Kc</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>BARK_DESENS</ci>
                <apply>
                    <times/>
                    <ci>k_bar_kp</ci>
                    <apply>
                        <plus/>
                        <ci>LR</ci>
                        <ci>LRG</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>BARK_RESENS</ci>
                <apply>
                    <times/>
                    <ci>k_bar_km</ci>
                    <ci>b1_AR_d</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PKA_DESENS</ci>
                <apply>
                    <times/>
                    <ci>k_p_kap</ci>
                    <ci>PKAC_I</ci>
                    <ci>b1_AR_tot</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PKA_RESENS</ci>
                <apply>
                    <times/>
                    <ci>k_p_kam</ci>
                    <ci>b1_AR_p</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>G_ACT</ci>
                <apply>
                    <times/>
                    <ci>k_g_act</ci>
                    <apply>
                        <plus/>
                        <ci>RG</ci>
                        <ci>LRG</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>HYD</ci>
                <apply>
                    <times/>
                    <ci>k_hyd</ci>
                    <ci>Gs_agtp_tot</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>REASSOC</ci>
                <apply>
                    <times/>
                    <ci>k_reassoc</ci>
                    <ci>Gs_agdp</ci>
                    <ci>Gs_bg</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>L</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>L_totmax</ci>
                        <ci>LR</ci>
                    </apply>
                    <ci>LRG</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>R</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <ci>b1_AR_tot</ci>
                            <ci>LR</ci>
                        </apply>
                        <ci>LRG</ci>
                    </apply>
                    <ci>RG</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Gs</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>Gs_tot</ci>
                        <ci>LRG</ci>
                    </apply>
                    <ci>RG</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>b1_AR_tot</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <ci>BARK_RESENS</ci>
                        <ci>BARK_DESENS</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>PKA_RESENS</ci>
                        <ci>PKA_DESENS</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>b1_AR_d</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>BARK_DESENS</ci>
                    <ci>BARK_RESENS</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>b1_AR_p</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>PKA_DESENS</ci>
                    <ci>PKA_RESENS</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Gs_agtp_tot</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>G_ACT</ci>
                    <ci>HYD</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Gs_agdp</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>HYD</ci>
                    <ci>REASSOC</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Gs_bg</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>G_ACT</ci>
                    <ci>REASSOC</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="cAMP_module">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="AC_tot" public_interface="in" units="uM"/>
        <variable name="ATP" public_interface="in" units="uM"/>
        <variable name="PDE_tot" public_interface="in" units="uM"/>
        <variable name="IBMX_tot" public_interface="in" units="uM"/>
        <variable name="Fsk_tot" public_interface="in" units="uM"/>
        <variable name="k_ac_basal" public_interface="in" units="per_sec"/>
        <variable name="k_ac_gsa" public_interface="in" units="per_sec"/>
        <variable name="k_ac_fsk" public_interface="in" units="per_sec"/>
        <variable name="k_pde" public_interface="in" units="per_sec"/>
        <variable name="Km_basal" public_interface="in" units="uM"/>
        <variable name="Km_gsa" public_interface="in" units="uM"/>
        <variable name="Km_fsk" public_interface="in" units="uM"/>
        <variable name="Km_pde" public_interface="in" units="uM"/>
        <variable name="K_gsa" public_interface="in" units="uM"/>
        <variable name="K_fsk" public_interface="in" units="uM"/>
        <variable name="Ki_ibmx" public_interface="in" units="uM"/>
        <variable name="cAMP" public_interface="in" units="uM"/>
        <variable cmeta:id="Gsa_GTP" name="Gsa_GTP" units="uM"/>
        <variable cmeta:id="FSK" name="Fsk" units="uM"/>
        <variable cmeta:id="AC" name="AC" units="uM"/>
        <variable cmeta:id="PDE" name="PDE" units="uM"/>
        <variable cmeta:id="IBMX" name="IBMX" units="uM"/>
        <variable initial_value="0.8453" name="cAMP_tot" public_interface="out" units="uM"/>
        <variable cmeta:id="Gsa_GTP_AC" name="Gsa_GTP_AC" units="uM"/>
        <variable cmeta:id="Fsk_AC" name="Fsk_AC" units="uM"/>
        <variable cmeta:id="AC_ACT_GSA" name="AC_ACT_GSA" units="uM"/>
        <variable cmeta:id="AC_ACT_BASAL" name="AC_ACT_BASAL" units="uM"/>
        <variable cmeta:id="AC_ACT_FSK" name="AC_ACT_FSK" units="uM"/>
        <variable cmeta:id="PDE_ACT" name="PDE_ACT" units="uM"/>
        <variable name="PDE_IBMX" units="uM"/>
        <variable name="Gs_agtp_tot" public_interface="in" units="uM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Gsa_GTP_AC</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>Gsa_GTP</ci>
                        <ci>AC</ci>
                    </apply>
                    <ci>K_gsa</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Fsk_AC</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>Fsk</ci>
                        <ci>AC</ci>
                    </apply>
                    <ci>K_fsk</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>AC_ACT_BASAL</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k_ac_basal</ci>
                        <ci>AC</ci>
                        <ci>ATP</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_basal</ci>
                        <ci>ATP</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>AC_ACT_GSA</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k_ac_gsa</ci>
                        <ci>Gsa_GTP_AC</ci>
                        <ci>ATP</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_gsa</ci>
                        <ci>ATP</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>AC_ACT_FSK</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k_ac_fsk</ci>
                        <ci>Fsk_AC</ci>
                        <ci>ATP</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_fsk</ci>
                        <ci>ATP</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PDE_ACT</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k_pde</ci>
                        <ci>PDE</ci>
                        <ci>cAMP</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pde</ci>
                        <ci>cAMP</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PDE_IBMX</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>PDE</ci>
                        <ci>IBMX</ci>
                    </apply>
                    <ci>Ki_ibmx</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Gsa_GTP</ci>
                <apply>
                    <minus/>
                    <ci>Gs_agtp_tot</ci>
                    <ci>Gsa_GTP_AC</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Fsk</ci>
                <apply>
                    <minus/>
                    <ci>Fsk_tot</ci>
                    <ci>Fsk_AC</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>AC</ci>
                <apply>
                    <minus/>
                    <ci>AC_tot</ci>
                    <ci>Gsa_GTP_AC</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PDE</ci>
                <apply>
                    <minus/>
                    <ci>PDE_tot</ci>
                    <ci>PDE_IBMX</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IBMX</ci>
                <apply>
                    <minus/>
                    <ci>IBMX_tot</ci>
                    <ci>PDE_IBMX</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>cAMP_tot</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <ci>AC_ACT_BASAL</ci>
                        <ci>AC_ACT_GSA</ci>
                        <ci>AC_ACT_FSK</ci>
                    </apply>
                    <ci>PDE_ACT</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="PKA_module">
        <variable name="PKAI_tot" public_interface="in" units="uM"/>
        <variable name="PKAII_tot" public_interface="in" units="uM"/>
        <variable name="PKI_tot" public_interface="in" units="uM"/>
        <variable name="K_a" public_interface="in" units="uM"/>
        <variable name="K_b" public_interface="in" units="uM"/>
        <variable name="K_d" public_interface="in" units="uM"/>
        <variable name="Ki_pki" public_interface="in" units="uM"/>
        <variable cmeta:id="PKI" name="PKI" units="uM"/>
        <variable cmeta:id="A2RC_I" name="A2RC_I" units="uM"/>
        <variable cmeta:id="A2R_I" name="A2R_I" units="uM"/>
        <variable cmeta:id="A2RC_II" name="A2RC_II" units="uM"/>
        <variable cmeta:id="A2R_II" name="A2R_II" units="uM"/>
        <variable cmeta:id="ARC_I" name="ARC_I" units="uM"/>
        <variable cmeta:id="ARC_II" name="ARC_II" units="uM"/>
        <variable cmeta:id="PKA_temp" name="PKA_temp" units="uM"/>
        <variable cmeta:id="cAMP" name="cAMP" public_interface="out" units="uM"/>
        <variable cmeta:id="PKAC_I" name="PKAC_I" public_interface="out" units="uM"/>
        <variable cmeta:id="PKAC_II" name="PKAC_II" public_interface="out" units="uM"/>
        <variable name="cAMP_tot" public_interface="in" units="uM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>PKI</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>PKI_tot</ci>
                        <ci>Ki_pki</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Ki_pki</ci>
                        <ci>PKAC_I</ci>
                        <ci>PKAC_II</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>A2RC_I</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <ci>PKAC_I</ci>
                        <ci>K_d</ci>
                    </apply>
                    <ci>PKAC_I</ci>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <ci>PKI</ci>
                            <ci>Ki_pki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>A2R_I</ci>
                <apply>
                    <times/>
                    <ci>PKAC_I</ci>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <ci>PKI</ci>
                            <ci>Ki_pki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>A2RC_II</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <ci>PKAC_II</ci>
                        <ci>K_d</ci>
                    </apply>
                    <ci>PKAC_II</ci>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <ci>PKI</ci>
                            <ci>Ki_pki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>A2R_II</ci>
                <apply>
                    <times/>
                    <ci>PKAC_II</ci>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <ci>PKI</ci>
                            <ci>Ki_pki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ARC_I</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <ci>K_a</ci>
                        <ci>cAMP</ci>
                    </apply>
                    <ci>A2RC_I</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ARC_II</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <ci>K_a</ci>
                        <ci>cAMP</ci>
                    </apply>
                    <ci>A2RC_II</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PKA_temp</ci>
                <apply>
                    <plus/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>K_a</ci>
                            <ci>K_b</ci>
                        </apply>
                        <ci>K_d</ci>
                    </apply>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>K_a</ci>
                            <ci>cAMP</ci>
                        </apply>
                        <ci>K_d</ci>
                    </apply>
                    <apply>
                        <divide/>
                        <apply>
                            <power/>
                            <ci>cAMP</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>K_d</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>cAMP</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>cAMP_tot</ci>
                        <apply>
                            <plus/>
                            <ci>ARC_I</ci>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                <ci>A2RC_I</ci>
                            </apply>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                <ci>A2R_I</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>ARC_II</ci>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            <ci>A2RC_II</ci>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            <ci>A2R_II</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>PKAI_tot</ci>
                        <apply>
                            <power/>
                            <ci>cAMP</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>PKAC_I</ci>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <ci>PKI</ci>
                                <ci>Ki_pki</ci>
                            </apply>
                        </apply>
                        <apply>
                            <plus/>
                            <apply>
                                <times/>
                                <ci>PKA_temp</ci>
                                <ci>PKAC_I</ci>
                            </apply>
                            <apply>
                                <power/>
                                <ci>cAMP</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>PKAII_tot</ci>
                        <apply>
                            <power/>
                            <ci>cAMP</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>PKAC_II</ci>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <ci>PKI</ci>
                                <ci>Ki_pki</ci>
                            </apply>
                        </apply>
                        <apply>
                            <plus/>
                            <apply>
                                <times/>
                                <ci>PKA_temp</ci>
                                <ci>PKAC_II</ci>
                            </apply>
                            <apply>
                                <power/>
                                <ci>cAMP</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="PLB_module">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="PLB_tot" public_interface="in" units="uM"/>
        <variable name="PP1_tot" public_interface="in" units="uM"/>
        <variable name="Inhib1_tot" public_interface="in" units="uM"/>
        <variable name="k_pka_plb" public_interface="in" units="per_sec"/>
        <variable name="Km_pka_plb" public_interface="in" units="uM"/>
        <variable name="k_pp1_plb" public_interface="in" units="per_sec"/>
        <variable name="Km_pp1_plb" public_interface="in" units="uM"/>
        <variable name="k_pka_i1" public_interface="in" units="per_sec"/>
        <variable name="Km_pka_i1" public_interface="in" units="uM"/>
        <variable name="Vmax_pp2a_i1" public_interface="in" units="uM_per_sec"/>
        <variable name="Km_pp2a_i1" public_interface="in" units="uM"/>
        <variable name="Ki_inhib1" public_interface="in" units="uM"/>
        <variable name="PLB" units="uM"/>
        <variable cmeta:id="PLB_PHOSPH" name="PLB_PHOSPH" units="uM_per_sec"/>
        <variable cmeta:id="PLB_DEPHOSPH" name="PLB_DEPHOSPH" units="uM_per_sec"/>
        <variable name="Inhib1" units="uM"/>
        <variable cmeta:id="Inhib1p_PP1" name="Inhib1p_PP1" units="uM"/>
        <variable cmeta:id="Inhib1_PHOSPH" name="Inhib1_PHOSPH" units="uM_per_sec"/>
        <variable name="Inhib1_DEPHOSPH" units="uM_per_sec"/>
        <variable initial_value="4.105" name="PLB_p" units="uM"/>
        <variable initial_value="0.0526" name="Inhib1p_tot" units="uM"/>
        <variable cmeta:id="Inhib1p" name="Inhib1p" units="uM"/>
        <variable cmeta:id="PP1" name="PP1" units="uM"/>
        <variable name="frac_PLB_p" units="dimensionless"/>
        <variable name="frac_PLB" public_interface="out" units="dimensionless"/>
        <variable name="frac_PLB_o" public_interface="out" units="dimensionless"/>
        <variable name="PKAC_I" public_interface="in" units="uM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>PLB</ci>
                <apply>
                    <minus/>
                    <ci>PLB_tot</ci>
                    <ci>PLB_p</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PLB_PHOSPH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k_pka_plb</ci>
                        <ci>PKAC_I</ci>
                        <ci>PLB</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pka_plb</ci>
                        <ci>PLB</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PLB_DEPHOSPH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k_pp1_plb</ci>
                        <ci>PP1</ci>
                        <ci>PLB_p</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pp1_plb</ci>
                        <ci>PLB_p</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Inhib1</ci>
                <apply>
                    <minus/>
                    <ci>Inhib1_tot</ci>
                    <ci>Inhib1p_tot</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Inhib1p_PP1</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>Inhib1p</ci>
                        <ci>PP1</ci>
                    </apply>
                    <ci>Ki_inhib1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Inhib1_PHOSPH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k_pka_i1</ci>
                        <ci>PKAC_I</ci>
                        <ci>Inhib1</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pka_i1</ci>
                        <ci>Inhib1</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Inhib1_DEPHOSPH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>Vmax_pp2a_i1</ci>
                        <ci>Inhib1p_tot</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pp2a_i1</ci>
                        <ci>Inhib1p_tot</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>PLB_p</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>PLB_PHOSPH</ci>
                    <ci>PLB_DEPHOSPH</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Inhib1p_tot</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>Inhib1_PHOSPH</ci>
                    <ci>Inhib1_DEPHOSPH</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Inhib1p</ci>
                <apply>
                    <minus/>
                    <ci>Inhib1p_tot</ci>
                    <ci>Inhib1p_PP1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PP1</ci>
                <apply>
                    <minus/>
                    <ci>PP1_tot</ci>
                    <ci>Inhib1p_PP1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>frac_PLB_p</ci>
                <apply>
                    <divide/>
                    <ci>PLB_p</ci>
                    <ci>PLB_tot</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>frac_PLB</ci>
                <apply>
                    <divide/>
                    <ci>PLB</ci>
                    <ci>PLB_tot</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>frac_PLB_o</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9613</cn>
            </apply>
        </math>
    </component>
    <component name="LCC_module">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="epsilon" public_interface="in" units="dimensionless"/>
        <variable name="LCC_tot" public_interface="in" units="uM"/>
        <variable name="PP1_lcc_tot" public_interface="in" units="uM"/>
        <variable name="PP2A_lcc_tot" public_interface="in" units="uM"/>
        <variable name="k_pka_lcc" public_interface="in" units="per_sec"/>
        <variable name="Km_pka_lcc" public_interface="in" units="uM"/>
        <variable name="k_pp1_lcc" public_interface="in" units="per_sec"/>
        <variable name="Km_pp1_lcc" public_interface="in" units="uM"/>
        <variable name="k_pp2a_lcc" public_interface="in" units="per_sec"/>
        <variable name="Km_pp2a_lcc" public_interface="in" units="uM"/>
        <variable name="LCCa" units="uM"/>
        <variable cmeta:id="LCCa_PHOSPH" name="LCCa_PHOSPH" units="uM_per_sec"/>
        <variable name="LCCa_DEPHOSPH" units="uM_per_sec"/>
        <variable name="LCCb" units="uM"/>
        <variable cmeta:id="LCCb_PHOSPH" name="LCCb_PHOSPH" units="uM_per_sec"/>
        <variable name="LCCb_DEPHOSPH" units="uM_per_sec"/>
        <variable initial_value="5.103e-3" name="LCCa_p" units="uM"/>
        <variable initial_value="5.841e-3" name="LCCb_p" units="uM"/>
        <variable name="frac_LCCa_p" public_interface="out" units="dimensionless"/>
        <variable name="frac_LCCa_po" public_interface="out" units="dimensionless"/>
        <variable name="frac_LCCb_p" public_interface="out" units="dimensionless"/>
        <variable name="frac_LCCb_po" public_interface="out" units="dimensionless"/>
        <variable name="PKAC_II" public_interface="in" units="uM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>LCCa</ci>
                <apply>
                    <minus/>
                    <ci>LCC_tot</ci>
                    <ci>LCCa_p</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>LCCa_PHOSPH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>epsilon</ci>
                        <ci>k_pka_lcc</ci>
                        <ci>PKAC_II</ci>
                        <ci>LCCa</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pka_lcc</ci>
                        <apply>
                            <times/>
                            <ci>epsilon</ci>
                            <ci>LCCa</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>LCCa_DEPHOSPH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>epsilon</ci>
                        <ci>k_pp2a_lcc</ci>
                        <ci>PP2A_lcc_tot</ci>
                        <ci>LCCa_p</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pp2a_lcc</ci>
                        <apply>
                            <times/>
                            <ci>epsilon</ci>
                            <ci>LCCa_p</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>LCCb</ci>
                <apply>
                    <minus/>
                    <ci>LCC_tot</ci>
                    <ci>LCCb_p</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>LCCb_PHOSPH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>epsilon</ci>
                        <ci>k_pka_lcc</ci>
                        <ci>PKAC_II</ci>
                        <ci>LCCb</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pka_lcc</ci>
                        <apply>
                            <times/>
                            <ci>epsilon</ci>
                            <ci>LCCb</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>LCCb_DEPHOSPH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>epsilon</ci>
                        <ci>k_pp1_lcc</ci>
                        <ci>PP1_lcc_tot</ci>
                        <ci>LCCb_p</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_pp1_lcc</ci>
                        <apply>
                            <times/>
                            <ci>epsilon</ci>
                            <ci>LCCb_p</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>LCCa_p</ci>
                </apply>
                <apply>
                    <minus/>
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                    <ci>LCCa_DEPHOSPH</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>LCCb_p</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>LCCb_PHOSPH</ci>
                    <ci>LCCb_DEPHOSPH</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>frac_LCCa_p</ci>
                <apply>
                    <divide/>
                    <ci>LCCa_p</ci>
                    <ci>LCC_tot</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>frac_LCCa_po</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2041</cn>
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            <apply>
                <eq/>
                <ci>frac_LCCb_p</ci>
                <apply>
                    <divide/>
                    <ci>LCCb_p</ci>
                    <ci>LCC_tot</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>frac_LCCb_po</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2336</cn>
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        </math>
    </component>
    <component name="Nernst_Potentials">
        <variable name="E_Na" public_interface="out" units="mV"/>
        <variable name="E_K" public_interface="out" units="mV"/>
        <variable name="E_Ca" public_interface="out" units="mV"/>
        <variable name="E_Cl" public_interface="out" units="mV"/>
        <variable initial_value="8314" name="R" units="joules_per_mole_kelvin"/>
        <variable initial_value="96485" name="Frdy" public_interface="out" units="coulombs_per_mole"/>
        <variable name="FoRT" public_interface="out" units="per_mV"/>
        <variable initial_value="1" name="z_Na" public_interface="out" units="dimensionless"/>
        <variable initial_value="1" name="z_K" public_interface="out" units="dimensionless"/>
        <variable initial_value="2" name="z_Ca" public_interface="out" units="dimensionless"/>
        <variable name="Temp" public_interface="in" units="kelvin"/>
        <variable name="Na_ext" public_interface="in" units="mM"/>
        <variable name="K_ext" public_interface="in" units="mM"/>
        <variable name="Ca_ext" public_interface="in" units="mM"/>
        <variable name="Na_i" public_interface="in" units="mM"/>
        <variable name="K_i" public_interface="in" units="mM"/>
        <variable name="Ca_i" public_interface="in" units="mM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>FoRT</ci>
                <apply>
                    <divide/>
                    <apply>
                        <divide/>
                        <ci>Frdy</ci>
                        <ci>R</ci>
                    </apply>
                    <ci>Temp</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_Na</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <times/>
                            <ci>FoRT</ci>
                            <ci>z_Na</ci>
                        </apply>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Na_ext</ci>
                            <ci>Na_i</ci>
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                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_K</ci>
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                    <times/>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <times/>
                            <ci>FoRT</ci>
                            <ci>z_K</ci>
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                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>K_ext</ci>
                            <ci>K_i</ci>
                        </apply>
                    </apply>
                </apply>
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            <apply>
                <eq/>
                <ci>E_Ca</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <times/>
                            <ci>FoRT</ci>
                            <ci>z_Ca</ci>
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                    <apply>
                        <ln/>
                        <apply>
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                            <ci>Ca_ext</ci>
                            <ci>Ca_i</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_Cl</ci>
                <apply>
                    <minus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
                </apply>
            </apply>
        </math>
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    <component name="Fast_Na_Current">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="am" units="per_sec"/>
        <variable name="bm" units="per_sec"/>
        <variable name="ah" units="per_sec"/>
        <variable name="aj" units="per_sec"/>
        <variable name="bh" units="per_sec"/>
        <variable name="bj" units="per_sec"/>
        <variable initial_value="1.4e-3" name="m" units="dimensionless"/>
        <variable initial_value="0.99" name="h" units="dimensionless"/>
        <variable initial_value="0.99" name="j" units="dimensionless"/>
        <variable name="I_Na" public_interface="out" units="uA_per_uF"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <variable name="E_Na" public_interface="in" units="mV"/>
        <variable name="G_Na" public_interface="in" units="mS_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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                <eq/>
                <ci>am</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.32</cn>
                        <apply>
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                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">47.13</cn>
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                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">1</cn>
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                            <exp/>
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                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
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                                <apply>
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                                    <ci>V_m</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">47.13</cn>
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                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>bm</ci>
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                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.08</cn>
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                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <ci>V_m</ci>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11</cn>
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            <apply>
                <eq/>
                <ci>ah</ci>
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                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
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                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.135</cn>
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                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">80</cn>
                                        <ci>V_m</ci>
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                                    <apply>
                                        <minus/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6.8</cn>
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                                </apply>
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            <apply>
                <eq/>
                <ci>aj</ci>
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                    <piece>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
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                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
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                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">1.2714   <sep/>
                                 5</cn>
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                                        <apply>
                                            <exp/>
                                            <apply>
                                                <times/>
                                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.2444</cn>
                                                <ci>V_m</ci>
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                                    </apply>
                                    <apply>
                                        <times/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">3.474   <sep/>
                              -5</cn>
                                        <apply>
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                                            <apply>
                                                <times/>
                                                <apply>
                                                    <minus/>
                                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.04391</cn>
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                                                <ci>V_m</ci>
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                                <apply>
                                    <plus/>
                                    <ci>V_m</ci>
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                                        <times/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.311</cn>
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                                            <ci>V_m</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">79.23</cn>
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            <apply>
                <eq/>
                <ci>bh</ci>
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                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.13</cn>
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                                    <apply>
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                                                    <ci>V_m</ci>
                                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10.66</cn>
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                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11.1</cn>
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                            <ci>V_m</ci>
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                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
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                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.56</cn>
                                <apply>
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                                    <apply>
                                        <times/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.079</cn>
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                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">3.1   <sep/>
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                                    <apply>
                                        <times/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.35</cn>
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                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.3</cn>
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                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_mV">2.575   <sep/>
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                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
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                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">32</cn>
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                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
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                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1212</cn>
                                <apply>
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                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.01052</cn>
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                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1378</cn>
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                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                <ci>m</ci>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>bm</ci>
                            <ci>m</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>h</ci>
                </apply>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="unknown">1   <sep/>
               3</cn>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>ah</ci>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                <ci>h</ci>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>bh</ci>
                            <ci>h</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>j</ci>
                </apply>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="unknown">1   <sep/>
               3</cn>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <ci>aj</ci>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                <ci>j</ci>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>bj</ci>
                            <ci>j</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_Na</ci>
                <apply>
                    <times/>
                    <ci>G_Na</ci>
                    <apply>
                        <power/>
                        <ci>m</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                    </apply>
                    <ci>h</ci>
                    <ci>j</ci>
                    <apply>
                        <minus/>
                        <ci>V_m</ci>
                        <ci>E_Na</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="L_Type_Calcium_Current">
        <variable name="a_lcc" units="per_sec"/>
        <variable name="b_lcc" units="per_sec"/>
        <variable name="f_lcc" units="dimensionless"/>
        <variable name="y_lcc_inf" units="dimensionless"/>
        <variable name="tau_y_lcc" units="second"/>
        <variable name="gamma" units="per_mM_per_sec"/>
        <variable name="v_gamma" units="per_mM_per_sec"/>
        <variable name="v_omega" units="dimensionless"/>
        <variable initial_value="0" name="v" units="dimensionless"/>
        <variable initial_value="0" name="w" units="dimensionless"/>
        <variable initial_value="0.13" name="x" units="dimensionless"/>
        <variable initial_value="0.96" name="y" units="dimensionless"/>
        <variable initial_value="0.92" name="z" units="dimensionless"/>
        <variable name="i_bar_Ca" units="dimensionless"/>
        <variable name="i_bar_K" units="dimensionless"/>
        <variable name="f_avail" units="dimensionless"/>
        <variable name="I_Ca" public_interface="out" units="uA_per_uF"/>
        <variable name="I_CaK" public_interface="out" units="uA_per_uF"/>
        <variable name="I_Ca_tot" public_interface="out" units="uA_per_uF"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="K_ext" public_interface="in" units="mM"/>
        <variable name="Ca_ext" public_interface="in" units="mM"/>
        <variable name="f" public_interface="in" units="per_sec"/>
        <variable name="g" public_interface="in" units="per_sec"/>
        <variable name="gamma_o" public_interface="in" units="per_mM_per_sec"/>
        <variable name="omega" public_interface="in" units="per_sec"/>
        <variable name="p_Ca" public_interface="in" units="cm_per_sec"/>
        <variable name="p_K" public_interface="in" units="cm_per_sec"/>
        <variable name="N_lcc" public_interface="in" units="dimensionless"/>
        <variable name="I_Ca05" public_interface="in" units="uA_per_uF"/>
        <variable name="frac_LCCa_p" public_interface="in" units="dimensionless"/>
        <variable name="frac_LCCa_po" public_interface="in" units="dimensionless"/>
        <variable name="frac_LCCb_p" public_interface="in" units="dimensionless"/>
        <variable name="frac_LCCb_po" public_interface="in" units="dimensionless"/>
        <variable name="Frdy" public_interface="in" units="coulombs_per_mole"/>
        <variable name="FoRT" public_interface="in" units="per_mV"/>
        <variable name="K_i" public_interface="in" units="mM"/>
        <variable name="Ca_i" public_interface="in" units="mM"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>a_lcc</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_sec">400</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <plus/>
                                <ci>V_m</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">2</cn>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>b_lcc</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_sec">50</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                </apply>
                                <apply>
                                    <plus/>
                                    <ci>V_m</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">2</cn>
                                </apply>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">13</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>f_lcc</ci>
                <apply>
                    <times/>
                    <ci>f</ci>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">0.375</cn>
                                <ci>frac_LCCa_p</ci>
                            </apply>
                            <ci>frac_LCCa_po</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.625</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>y_lcc_inf</ci>
                <apply>
                    <plus/>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V_m</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">55</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">7.5</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <apply>
                                            <minus/>
                                            <ci>V_m</ci>
                                        </apply>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">21</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_y_lcc</ci>
                <apply>
                    <plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.02</cn>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.3</cn>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V_m</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">30</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">9.5</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>gamma</ci>
                <apply>
                    <times/>
                    <ci>gamma_o</ci>
                    <ci>Ca_i</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_gamma</ci>
                <apply>
                    <times/>
                    <ci>gamma</ci>
                    <apply>
                        <plus/>
                        <apply>
                            <power/>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                <ci>v</ci>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">2</cn>
                            <ci>v</ci>
                            <apply>
                                <power/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                    <ci>v</ci>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">4</cn>
                            <apply>
                                <power/>
                                <ci>v</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                    <ci>v</ci>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">8</cn>
                            <apply>
                                <power/>
                                <ci>v</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                            </apply>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                <ci>v</ci>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">16</cn>
                            <apply>
                                <power/>
                                <ci>v</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                            </apply>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                <apply>
                                    <divide/>
                                    <ci>f_lcc</ci>
                                    <ci>g</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_omega</ci>
                <apply>
                    <times/>
                    <ci>omega</ci>
                    <apply>
                        <plus/>
                        <apply>
                            <power/>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                <ci>w</ci>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">0.5</cn>
                            <ci>w</ci>
                            <apply>
                                <power/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                    <ci>w</ci>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">0.25</cn>
                            <apply>
                                <power/>
                                <ci>w</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                    <ci>w</ci>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">0.125</cn>
                            <apply>
                                <power/>
                                <ci>w</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                            </apply>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                <ci>w</ci>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">0.0625</cn>
                            <apply>
                                <power/>
                                <ci>w</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>v</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>a_lcc</ci>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <ci>v</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>b_lcc</ci>
                        <ci>v</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>w</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>a_lcc</ci>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <ci>w</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <ci>b_lcc</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>w</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>x</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>f_lcc</ci>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <ci>x</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>g</ci>
                        <ci>x</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>y</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>y_lcc_inf</ci>
                        <ci>y</ci>
                    </apply>
                    <ci>tau_y_lcc</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>z</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>v_omega</ci>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <ci>z</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>v_gamma</ci>
                        <ci>z</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_bar_Ca</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>p_Ca</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        <ci>V_m</ci>
                        <ci>Frdy</ci>
                        <ci>FoRT</ci>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">1   <sep/>
                        -3</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <times/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">2</cn>
                                        <ci>V_m</ci>
                                        <ci>FoRT</ci>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.341</cn>
                                <ci>Ca_ext</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                <ci>V_m</ci>
                                <ci>FoRT</ci>
                            </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_bar_K</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>p_K</ci>
                        <ci>V_m</ci>
                        <ci>Frdy</ci>
                        <ci>FoRT</ci>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <ci>K_i</ci>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <times/>
                                        <ci>V_m</ci>
                                        <ci>FoRT</ci>
                                    </apply>
                                </apply>
                            </apply>
                            <ci>K_ext</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <ci>V_m</ci>
                                <ci>FoRT</ci>
                            </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>f_avail</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">0.5</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">0.4</cn>
                                <ci>frac_LCCb_p</ci>
                            </apply>
                            <ci>frac_LCCb_po</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_Ca</ci>
                <apply>
                    <times/>
                    <ci>i_bar_Ca</ci>
                    <ci>N_lcc</ci>
                    <ci>f_avail</ci>
                    <apply>
                        <power/>
                        <ci>v</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                    </apply>
                    <ci>x</ci>
                    <ci>y</ci>
                    <ci>z</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_CaK</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <ci>i_bar_K</ci>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <ci>I_Ca</ci>
                                <ci>I_Ca05</ci>
                            </apply>
                        </apply>
                    </apply>
                    <ci>N_lcc</ci>
                    <ci>f_avail</ci>
                    <apply>
                        <power/>
                        <ci>v</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                    </apply>
                    <ci>x</ci>
                    <ci>y</ci>
                    <ci>z</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_Ca_tot</ci>
                <apply>
                    <plus/>
                    <ci>I_Ca</ci>
                    <ci>I_CaK</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Transient_Outward_K_Current">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="r_toss" units="dimensionless"/>
        <variable name="s_toss" units="dimensionless"/>
        <variable name="tau_r_to" units="second"/>
        <variable name="tau_s_to" units="second"/>
        <variable name="tau_ss_to" units="second"/>
        <variable initial_value="1.4e-3" name="r_to" units="dimensionless"/>
        <variable initial_value="1" name="s_to" units="dimensionless"/>
        <variable initial_value="0.613" name="ss_to" units="dimensionless"/>
        <variable name="I_to" public_interface="out" units="uA_per_uF"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <variable name="E_K" public_interface="in" units="mV"/>
        <variable name="G_to" public_interface="in" units="mS_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>r_toss</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V_m</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10.6</cn>
                                </apply>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11.42</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>s_toss</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V_m</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">43.5</cn>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6.8841</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_r_to</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.03577</cn>
                                    <apply>
                                        <plus/>
                                        <ci>V_m</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">50</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
                                    </apply>
                                    <apply>
                                        <plus/>
                                        <ci>V_m</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">38</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_s_to</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.35</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                </apply>
                                <apply>
                                    <power/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <plus/>
                                            <ci>V_m</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">70</cn>
                                        </apply>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">15</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.035</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_ss_to</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">3.7</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                </apply>
                                <apply>
                                    <power/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <plus/>
                                            <ci>V_m</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">70</cn>
                                        </apply>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">30</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.035</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>r_to</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>r_toss</ci>
                        <ci>r_to</ci>
                    </apply>
                    <ci>tau_r_to</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>s_to</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>s_toss</ci>
                        <ci>s_to</ci>
                    </apply>
                    <ci>tau_s_to</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>ss_to</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>s_toss</ci>
                        <ci>ss_to</ci>
                    </apply>
                    <ci>tau_ss_to</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_to</ci>
                <apply>
                    <times/>
                    <ci>G_to</ci>
                    <ci>r_to</ci>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.886</cn>
                            <ci>s_to</ci>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.114</cn>
                            <ci>ss_to</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>V_m</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Steady_State_K_Current">
        <variable name="time" public_interface="in" units="second"/>
        <variable name="r_ss_inf" units="dimensionless"/>
        <variable name="tau_r_ss" units="second"/>
        <variable name="s_ss_inf" units="dimensionless"/>
        <variable name="tau_s_ss" units="second"/>
        <variable initial_value="198e-3" name="r_ss" units="dimensionless"/>
        <variable initial_value="0.43" name="s_ss" units="dimensionless"/>
        <variable name="I_ss" public_interface="out" units="uA_per_uF"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <variable name="E_K" public_interface="in" units="mV"/>
        <variable name="G_ss" public_interface="in" units="mS_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>r_ss_inf</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V_m</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11.5</cn>
                                </apply>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11.82</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_r_ss</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.03577</cn>
                                    <apply>
                                        <plus/>
                                        <ci>V_m</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">50</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
                                    </apply>
                                    <apply>
                                        <plus/>
                                        <ci>V_m</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">38</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>s_ss_inf</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V_m</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">87.5</cn>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10.3</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_s_ss</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">2.1</cn>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>r_ss</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>r_ss_inf</ci>
                        <ci>r_ss</ci>
                    </apply>
                    <ci>tau_r_ss</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>s_ss</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>s_ss_inf</ci>
                        <ci>s_ss</ci>
                    </apply>
                    <ci>tau_s_ss</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_ss</ci>
                <apply>
                    <times/>
                    <ci>G_ss</ci>
                    <ci>r_ss</ci>
                    <ci>s_ss</ci>
                    <apply>
                        <minus/>
                        <ci>V_m</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Time_Independent_K_Current">
        <variable name="a_Ki" units="dimensionless"/>
        <variable name="b_Ki" units="dimensionless"/>
        <variable name="Ki_ss" units="dimensionless"/>
        <variable name="I_Ki" public_interface="out" units="uA_per_uF"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <variable name="E_K" public_interface="in" units="mV"/>
        <variable name="G_Ki_bar" public_interface="in" units="mS_per_uF"/>
        <variable name="K_ext" public_interface="in" units="mM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>a_Ki</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.02</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.2385</cn>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>V_m</ci>
                                        <ci>E_K</ci>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">59.215</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>b_Ki</ci>
                <apply>
                    <divide/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.49124</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.08032</cn>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V_m</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">5.476</cn>
                                        </apply>
                                        <ci>E_K</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.06175</cn>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>V_m</ci>
                                        <ci>E_K</ci>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">594.31</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.5143</cn>
                                </apply>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <ci>V_m</ci>
                                        <ci>E_K</ci>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">4.753</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Ki_ss</ci>
                <apply>
                    <divide/>
                    <ci>a_Ki</ci>
                    <apply>
                        <plus/>
                        <ci>a_Ki</ci>
                        <ci>b_Ki</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_Ki</ci>
                <apply>
                    <times/>
                    <ci>G_Ki_bar</ci>
                    <apply>
                        <root/>
                        <apply>
                            <divide/>
                            <ci>K_ext</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">5.4</cn>
                        </apply>
                    </apply>
                    <ci>Ki_ss</ci>
                    <apply>
                        <minus/>
                        <ci>V_m</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Plateau_K_Current">
        <variable name="Kp" units="dimensionless"/>
        <variable name="I_Kp" public_interface="out" units="uA_per_uF"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <variable name="E_K" public_interface="in" units="mV"/>
        <variable name="G_Kp" public_interface="in" units="mS_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Kp</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">7.488</cn>
                                    <ci>V_m</ci>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">5.98</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_Kp</ci>
                <apply>
                    <times/>
                    <ci>G_Kp</ci>
                    <ci>Kp</ci>
                    <apply>
                        <minus/>
                        <ci>V_m</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Na_Ca_Exchanger_Current">
        <variable name="s4" units="dimensionless"/>
        <variable name="s5" units="dimensionless"/>
        <variable name="I_NCX" public_interface="out" units="uA_per_uF"/>
        <variable name="Na_ext" public_interface="in" units="mM"/>
        <variable name="Ca_ext" public_interface="in" units="mM"/>
        <variable name="k_NaCa" public_interface="in" units="uA_per_uF"/>
        <variable name="Km_Na" public_interface="in" units="mM"/>
        <variable name="Km_Ca" public_interface="in" units="mM"/>
        <variable name="k_sat" public_interface="in" units="dimensionless"/>
        <variable name="eta" public_interface="in" units="dimensionless"/>
        <variable name="FoRT" public_interface="in" units="per_mV"/>
        <variable name="Na_i" public_interface="in" units="mM"/>
        <variable name="Ca_i" public_interface="in" units="mM"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>s4</ci>
                <apply>
                    <times/>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <ci>eta</ci>
                            <ci>V_m</ci>
                            <ci>FoRT</ci>
                        </apply>
                    </apply>
                    <apply>
                        <power/>
                        <ci>Na_i</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                    </apply>
                    <ci>Ca_ext</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>s5</ci>
                <apply>
                    <times/>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <ci>eta</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                            </apply>
                            <ci>V_m</ci>
                            <ci>FoRT</ci>
                        </apply>
                    </apply>
                    <apply>
                        <power/>
                        <ci>Na_ext</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                    </apply>
                    <ci>Ca_i</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_NCX</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <ci>k_NaCa</ci>
                        <apply>
                            <times/>
                            <apply>
                                <plus/>
                                <apply>
                                    <power/>
                                    <ci>Km_Na</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                </apply>
                                <apply>
                                    <power/>
                                    <ci>Na_ext</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                </apply>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>Km_Ca</ci>
                                <ci>Ca_ext</ci>
                            </apply>
                            <apply>
                                <plus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                <apply>
                                    <times/>
                                    <ci>k_sat</ci>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <ci>eta</ci>
                                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">1</cn>
                                            </apply>
                                            <ci>V_m</ci>
                                            <ci>FoRT</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>s4</ci>
                        <ci>s5</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Na_K_Pump_Current">
        <variable name="sigma" units="dimensionless"/>
        <variable name="f_NaK" units="dimensionless"/>
        <variable name="I_NaK" public_interface="out" units="uA_per_uF"/>
        <variable name="Na_ext" public_interface="in" units="mM"/>
        <variable name="K_ext" public_interface="in" units="mM"/>
        <variable name="I_bar_NaK" public_interface="in" units="uA_per_uF"/>
        <variable name="Km_Nai" public_interface="in" units="mM"/>
        <variable name="Km_Ko" public_interface="in" units="mM"/>
        <variable name="FoRT" public_interface="in" units="per_mV"/>
        <variable name="Na_i" public_interface="in" units="mM"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>sigma</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Na_ext</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">67.3</cn>
                            </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>f_NaK</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                                    </apply>
                                    <ci>V_m</ci>
                                    <ci>FoRT</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                            <ci>sigma</ci>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <ci>V_m</ci>
                                    </apply>
                                    <ci>FoRT</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_NaK</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>I_bar_NaK</ci>
                                <ci>f_NaK</ci>
                            </apply>
                            <apply>
                                <plus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                <apply>
                                    <power/>
                                    <apply>
                                        <divide/>
                                        <ci>Km_Nai</ci>
                                        <ci>Na_i</ci>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                                </apply>
                            </apply>
                        </apply>
                        <ci>K_ext</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>K_ext</ci>
                        <ci>Km_Ko</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Sarcolemmal_Ca_Pump_Current">
        <variable name="I_PCa" public_interface="out" units="uA_per_uF"/>
        <variable name="I_bar_PCa" public_interface="in" units="uA_per_uF"/>
        <variable name="Km_PCa" public_interface="in" units="mM"/>
        <variable name="Ca_i" public_interface="in" units="mM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>I_PCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>I_bar_PCa</ci>
                        <ci>Ca_i</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Km_PCa</ci>
                        <ci>Ca_i</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Ca_Background_Current">
        <variable name="I_CaB" public_interface="out" units="uA_per_uF"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <variable name="E_Ca" public_interface="in" units="mV"/>
        <variable name="G_CaB" public_interface="in" units="uA_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>I_CaB</ci>
                <apply>
                    <times/>
                    <ci>G_CaB</ci>
                    <apply>
                        <minus/>
                        <ci>V_m</ci>
                        <ci>E_Ca</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Na_Background_Current">
        <variable name="I_NaB" public_interface="out" units="uA_per_uF"/>
        <variable name="V_m" public_interface="in" units="mV"/>
        <variable name="E_Na" public_interface="in" units="mV"/>
        <variable name="G_NaB" public_interface="in" units="uA_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>I_NaB</ci>
                <apply>
                    <times/>
                    <ci>G_NaB</ci>
                    <apply>
                        <minus/>
                        <ci>V_m</ci>
                        <ci>E_Na</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Total_Membrane_Currents">
        <variable name="I_Na_tot" public_interface="out" units="uA_per_uF"/>
        <variable name="I_K_tot" public_interface="out" units="uA_per_uF"/>
        <variable name="I_Ca_tot" public_interface="out" units="uA_per_uF"/>
        <variable name="I_Na" public_interface="in" units="uA_per_uF"/>
        <variable name="I_NaB" public_interface="in" units="uA_per_uF"/>
        <variable name="I_NCX" public_interface="in" units="uA_per_uF"/>
        <variable name="I_NaK" public_interface="in" units="uA_per_uF"/>
        <variable name="I_to" public_interface="in" units="uA_per_uF"/>
        <variable name="I_ss" public_interface="in" units="uA_per_uF"/>
        <variable name="I_Ki" public_interface="in" units="uA_per_uF"/>
        <variable name="I_Kp" public_interface="in" units="uA_per_uF"/>
        <variable name="I_CaK" public_interface="in" units="uA_per_uF"/>
        <variable name="I_Ca" public_interface="in" units="uA_per_uF"/>
        <variable name="I_CaB" public_interface="in" units="uA_per_uF"/>
        <variable name="I_PCa" public_interface="in" units="uA_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>I_Na_tot</ci>
                <apply>
                    <plus/>
                    <ci>I_Na</ci>
                    <ci>I_NaB</ci>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>I_NCX</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>I_NaK</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_K_tot</ci>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <apply>
                            <plus/>
                            <ci>I_to</ci>
                            <ci>I_ss</ci>
                            <ci>I_Ki</ci>
                            <ci>I_Kp</ci>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            <ci>I_NaK</ci>
                        </apply>
                    </apply>
                    <ci>I_CaK</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_Ca_tot</ci>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <ci>I_Ca</ci>
                        <ci>I_CaB</ci>
                        <ci>I_PCa</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>I_NCX</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Calcium_Induced_Calcium_Release">
        <variable name="t_rel" units="second"/>
        <variable name="ryr_on" units="dimensionless"/>
        <variable name="ryr_off" units="dimensionless"/>
        <variable name="g_rel" units="per_sec"/>
        <variable name="I_rel" public_interface="out" units="mM_per_sec"/>
        <variable name="tau_on" public_interface="in" units="second"/>
        <variable name="tau_off" public_interface="in" units="second"/>
        <variable name="G_max_rel" public_interface="in" units="mM_per_sec"/>
        <variable name="I_Ca_tot" public_interface="in" units="uA_per_uF"/>
        <variable name="Ca_jsr" public_interface="in" units="mM"/>
        <variable name="Ca_i" public_interface="in" units="mM"/>
        <variable name="trel" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>t_rel</ci>
                <apply>
                    <plus/>
                    <ci>trel</ci>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">2   <sep/>
               -3</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ryr_on</ci>
                <apply>
                    <minus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <ci>t_rel</ci>
                            </apply>
                            <ci>tau_on</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ryr_off</ci>
                <apply>
                    <exp/>
                    <apply>
                        <divide/>
                        <apply>
                            <minus/>
                            <ci>t_rel</ci>
                        </apply>
                        <ci>tau_off</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>g_rel</ci>
                <apply>
                    <divide/>
                    <ci>G_max_rel</ci>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>I_Ca_tot</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">5</cn>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="unknown">0.9</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_rel</ci>
                <apply>
                    <times/>
                    <ci>g_rel</ci>
                    <ci>ryr_on</ci>
                    <ci>ryr_off</ci>
                    <apply>
                        <minus/>
                        <ci>Ca_jsr</ci>
                        <ci>Ca_i</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Other_SR_Fluxes_and_Concentrations">
        <variable name="Km_up" units="mM"/>
        <variable name="I_up" public_interface="out" units="mM_per_sec"/>
        <variable name="I_leak" public_interface="out" units="mM_per_sec"/>
        <variable name="I_tr" units="mM_per_sec"/>
        <variable name="B_jsr" units="dimensionless"/>
        <variable initial_value="1.92" name="Ca_nsr" public_interface="out" units="mM"/>
        <variable initial_value="1.92" name="Ca_jsr" public_interface="out" units="mM"/>
        <variable name="SR_content" units="uM"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V_myo" public_interface="in" units="uL"/>
        <variable name="V_nsr" public_interface="in" units="uL"/>
        <variable name="V_jsr" public_interface="in" units="uL"/>
        <variable name="I_up_bar" public_interface="in" units="mM_per_sec"/>
        <variable name="Km_up0" public_interface="in" units="mM"/>
        <variable name="NSR_bar" public_interface="in" units="mM"/>
        <variable name="CSQN_bar" public_interface="in" units="mM"/>
        <variable name="Km_CSQN" public_interface="in" units="mM"/>
        <variable name="tau_tr" public_interface="in" units="second"/>
        <variable name="frac_PLB" public_interface="in" units="dimensionless"/>
        <variable name="frac_PLB_o" public_interface="in" units="dimensionless"/>
        <variable name="I_rel" public_interface="in" units="mM_per_sec"/>
        <variable name="Ca_i" public_interface="in" units="mM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Km_up</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>Km_up0</ci>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                <ci>frac_PLB</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            <ci>frac_PLB_o</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_up</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>I_up_bar</ci>
                        <apply>
                            <power/>
                            <ci>Ca_i</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <power/>
                            <ci>Km_up</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                            <power/>
                            <ci>Ca_i</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_leak</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>I_up_bar</ci>
                        <ci>Ca_nsr</ci>
                    </apply>
                    <ci>NSR_bar</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_tr</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>Ca_nsr</ci>
                        <ci>Ca_jsr</ci>
                    </apply>
                    <ci>tau_tr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>B_jsr</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>CSQN_bar</ci>
                                <ci>Km_CSQN</ci>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <plus/>
                                    <ci>Km_CSQN</ci>
                                    <ci>Ca_jsr</ci>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ca_nsr</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <ci>I_up</ci>
                        <ci>I_leak</ci>
                    </apply>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>I_tr</ci>
                            <ci>V_jsr</ci>
                        </apply>
                        <ci>V_nsr</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ca_jsr</ci>
                </apply>
                <apply>
                    <times/>
                    <ci>B_jsr</ci>
                    <apply>
                        <minus/>
                        <ci>I_tr</ci>
                        <ci>I_rel</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>SR_content</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="unknown">1   <sep/>
               3</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <plus/>
                                    <ci>Ca_jsr</ci>
                                    <apply>
                                        <divide/>
                                        <ci>Ca_jsr</ci>
                                        <ci>B_jsr</ci>
                                    </apply>
                                </apply>
                                <ci>V_jsr</ci>
                            </apply>
                            <ci>V_myo</ci>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>Ca_nsr</ci>
                                <ci>V_nsr</ci>
                            </apply>
                            <ci>V_myo</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Cytoplasmic_Calcium_Buffering">
        <variable name="b_trpn" units="dimensionless"/>
        <variable name="b_cmdn" units="dimensionless"/>
        <variable name="b_indo" units="dimensionless"/>
        <variable name="B_myo" public_interface="out" units="dimensionless"/>
        <variable name="TRPN_bar" public_interface="in" units="mM"/>
        <variable name="CMDN_bar" public_interface="in" units="mM"/>
        <variable name="INDO_bar" public_interface="in" units="mM"/>
        <variable name="Km_TRPN" public_interface="in" units="mM"/>
        <variable name="Km_CMDN" public_interface="in" units="mM"/>
        <variable name="Km_INDO" public_interface="in" units="mM"/>
        <variable name="Ca_i" public_interface="in" units="mM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>b_trpn</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>TRPN_bar</ci>
                        <ci>Km_TRPN</ci>
                    </apply>
                    <apply>
                        <power/>
                        <apply>
                            <plus/>
                            <ci>Km_TRPN</ci>
                            <ci>Ca_i</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>b_cmdn</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>CMDN_bar</ci>
                        <ci>Km_CMDN</ci>
                    </apply>
                    <apply>
                        <power/>
                        <apply>
                            <plus/>
                            <ci>Km_CMDN</ci>
                            <ci>Ca_i</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>b_indo</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>INDO_bar</ci>
                        <ci>Km_INDO</ci>
                    </apply>
                    <apply>
                        <power/>
                        <apply>
                            <plus/>
                            <ci>Km_INDO</ci>
                            <ci>Ca_i</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>B_myo</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>b_cmdn</ci>
                        <ci>b_trpn</ci>
                        <ci>b_trpn</ci>
                        <ci>b_indo</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Ion_Concentrations_and_Membrane_Potential">
        <variable initial_value="16" name="Na_i" public_interface="out" units="mM"/>
        <variable initial_value="145" name="K_i" public_interface="out" units="mM"/>
        <variable initial_value="1.58e-4" name="Ca_i" public_interface="out" units="mM"/>
        <variable initial_value="-85.66" name="V_m" public_interface="out" units="mV"/>
        <variable initial_value="0.9" name="trel" public_interface="out" units="second"/>
        <variable name="I_app" units="uA_per_uF"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V_myo" public_interface="in" units="uL"/>
        <variable name="V_nsr" public_interface="in" units="uL"/>
        <variable name="V_jsr" public_interface="in" units="uL"/>
        <variable name="A_Cap" public_interface="in" units="cm2"/>
        <variable name="Frdy" public_interface="in" units="coulombs_per_mole"/>
        <variable name="z_Na" public_interface="in" units="dimensionless"/>
        <variable name="z_K" public_interface="in" units="dimensionless"/>
        <variable name="z_Ca" public_interface="in" units="dimensionless"/>
        <variable name="I_Na_tot" public_interface="in" units="uA_per_uF"/>
        <variable name="I_K_tot" public_interface="in" units="uA_per_uF"/>
        <variable name="I_Ca_tot" public_interface="in" units="uA_per_uF"/>
        <variable name="I_leak" public_interface="in" units="mM_per_sec"/>
        <variable name="I_rel" public_interface="in" units="mM_per_sec"/>
        <variable name="I_up" public_interface="in" units="mM_per_sec"/>
        <variable name="B_myo" public_interface="in" units="dimensionless"/>
        <variable initial_value="-40" name="V_hold" units="mV"/>
        <variable initial_value="-10" name="V_test" units="mV"/>
        <variable name="V_clamp" units="mV"/>
        <variable initial_value="0.02" name="R_clamp" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>V_clamp</ci>
                <piecewise>
                    <piece>
                        <ci>V_test</ci>
                        <apply>
                            <and/>
                            <apply>
                                <gt/>
                                <ci>time</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">59.1</cn>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">59.5</cn>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>V_hold</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>I_app</ci>
                <piecewise>
                    <piece>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                        <apply>
                            <eq/>
                            <ci>protocol</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                        </apply>
                    </piece>
                    <piece>
                        <ci>I_pace</ci>
                        <apply>
                            <eq/>
                            <ci>protocol</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <ci>V_clamp</ci>
                                <ci>V_m</ci>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Na_i</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">1   <sep/>
                     3</cn>
                        </apply>
                        <ci>I_Na_tot</ci>
                        <ci>A_Cap</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>V_myo</ci>
                        <ci>z_Na</ci>
                        <ci>Frdy</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>K_i</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">1   <sep/>
                     3</cn>
                        </apply>
                        <ci>I_K_tot</ci>
                        <ci>A_Cap</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>V_myo</ci>
                        <ci>z_K</ci>
                        <ci>Frdy</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ca_i</ci>
                </apply>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <ci>B_myo</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">1   <sep/>
                           3</cn>
                                    <ci>I_Ca_tot</ci>
                                    <ci>A_Cap</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>V_myo</ci>
                                    <ci>z_Ca</ci>
                                    <ci>Frdy</ci>
                                </apply>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <ci>I_up</ci>
                                        <ci>I_leak</ci>
                                    </apply>
                                    <ci>V_nsr</ci>
                                </apply>
                                <ci>V_myo</ci>
                            </apply>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>I_rel</ci>
                                <ci>V_jsr</ci>
                            </apply>
                            <ci>V_myo</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>V_m</ci>
                </apply>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="unknown">1   <sep/>
                  3</cn>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <plus/>
                            <ci>I_Ca_tot</ci>
                            <ci>I_K_tot</ci>
                            <ci>I_Na_tot</ci>
                        </apply>
                        <ci>I_app</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>trel</ci>
                </apply>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">1   <sep/>
                        4</cn>
                                <ci>trel</ci>
                            </apply>
                        </apply>
                        <apply>
                            <gt/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="unknown">1   <sep/>
                           3</cn>
                                </apply>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>I_Ca_tot</ci>
                                        <ci>I_K_tot</ci>
                                        <ci>I_Na_tot</ci>
                                    </apply>
                                    <ci>I_app</ci>
                                </apply>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mV_per_sec">30   <sep/>
                     3</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
                    </otherwise>
                </piecewise>
            </apply>

        </math>
        <variable name="protocol" public_interface="in" units="dimensionless"/>
        <variable name="I_pace" public_interface="in" units="uA_per_uF"/>
    </component>
    <connection>
        <map_components component_1="environment" component_2="b1_AR_module"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="cAMP_module"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="PLB_module"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="LCC_module"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="Fast_Na_Current"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="L_Type_Calcium_Current"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="Transient_Outward_K_Current"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="Steady_State_K_Current"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="Other_SR_Fluxes_and_Concentrations"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="Ion_Concentrations_and_Membrane_Potential"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="protocol" variable_2="protocol"/>
    </connection>
    <connection>
        <map_components component_1="b1_AR_Gs_parameters" component_2="b1_AR_module"/>
        <map_variables variable_1="L_totmax" variable_2="L_totmax"/>
        <map_variables variable_1="sum_b1_AR" variable_2="sum_b1_AR"/>
        <map_variables variable_1="Gs_tot" variable_2="Gs_tot"/>
        <map_variables variable_1="Kl" variable_2="Kl"/>
        <map_variables variable_1="Kr" variable_2="Kr"/>
        <map_variables variable_1="Kc" variable_2="Kc"/>
        <map_variables variable_1="k_bar_kp" variable_2="k_bar_kp"/>
        <map_variables variable_1="k_bar_km" variable_2="k_bar_km"/>
        <map_variables variable_1="k_p_kap" variable_2="k_p_kap"/>
        <map_variables variable_1="k_p_kam" variable_2="k_p_kam"/>
        <map_variables variable_1="k_g_act" variable_2="k_g_act"/>
        <map_variables variable_1="k_hyd" variable_2="k_hyd"/>
        <map_variables variable_1="k_reassoc" variable_2="k_reassoc"/>
    </connection>
    <connection>
        <map_components component_1="cAMP_parameters" component_2="cAMP_module"/>
        <map_variables variable_1="AC_tot" variable_2="AC_tot"/>
        <map_variables variable_1="ATP" variable_2="ATP"/>
        <map_variables variable_1="PDE_tot" variable_2="PDE_tot"/>
        <map_variables variable_1="IBMX_tot" variable_2="IBMX_tot"/>
        <map_variables variable_1="Fsk_tot" variable_2="Fsk_tot"/>
        <map_variables variable_1="k_ac_basal" variable_2="k_ac_basal"/>
        <map_variables variable_1="k_ac_gsa" variable_2="k_ac_gsa"/>
        <map_variables variable_1="k_ac_fsk" variable_2="k_ac_fsk"/>
        <map_variables variable_1="k_pde" variable_2="k_pde"/>
        <map_variables variable_1="Km_basal" variable_2="Km_basal"/>
        <map_variables variable_1="Km_gsa" variable_2="Km_gsa"/>
        <map_variables variable_1="Km_fsk" variable_2="Km_fsk"/>
        <map_variables variable_1="Km_pde" variable_2="Km_pde"/>
        <map_variables variable_1="K_gsa" variable_2="K_gsa"/>
        <map_variables variable_1="K_fsk" variable_2="K_fsk"/>
        <map_variables variable_1="Ki_ibmx" variable_2="Ki_ibmx"/>
    </connection>
    <connection>
        <map_components component_1="PKA_parameters" component_2="PKA_module"/>
        <map_variables variable_1="PKAI_tot" variable_2="PKAI_tot"/>
        <map_variables variable_1="PKAII_tot" variable_2="PKAII_tot"/>
        <map_variables variable_1="PKI_tot" variable_2="PKI_tot"/>
        <map_variables variable_1="K_a" variable_2="K_a"/>
        <map_variables variable_1="K_b" variable_2="K_b"/>
        <map_variables variable_1="K_d" variable_2="K_d"/>
        <map_variables variable_1="Ki_pki" variable_2="Ki_pki"/>
    </connection>
    <connection>
        <map_components component_1="PLB_parameters" component_2="PLB_module"/>
        <map_variables variable_1="PLB_tot" variable_2="PLB_tot"/>
        <map_variables variable_1="PP1_tot" variable_2="PP1_tot"/>
        <map_variables variable_1="Inhib1_tot" variable_2="Inhib1_tot"/>
        <map_variables variable_1="k_pka_plb" variable_2="k_pka_plb"/>
        <map_variables variable_1="Km_pka_plb" variable_2="Km_pka_plb"/>
        <map_variables variable_1="k_pp1_plb" variable_2="k_pp1_plb"/>
        <map_variables variable_1="Km_pp1_plb" variable_2="Km_pp1_plb"/>
        <map_variables variable_1="k_pka_i1" variable_2="k_pka_i1"/>
        <map_variables variable_1="Km_pka_i1" variable_2="Km_pka_i1"/>
        <map_variables variable_1="Vmax_pp2a_i1" variable_2="Vmax_pp2a_i1"/>
        <map_variables variable_1="Km_pp2a_i1" variable_2="Km_pp2a_i1"/>
        <map_variables variable_1="Ki_inhib1" variable_2="Ki_inhib1"/>
    </connection>
    <connection>
        <map_components component_1="LCC_parameters" component_2="LCC_module"/>
        <map_variables variable_1="epsilon" variable_2="epsilon"/>
        <map_variables variable_1="LCC_tot" variable_2="LCC_tot"/>
        <map_variables variable_1="PP1_lcc_tot" variable_2="PP1_lcc_tot"/>
        <map_variables variable_1="PP2A_lcc_tot" variable_2="PP2A_lcc_tot"/>
        <map_variables variable_1="k_pka_lcc" variable_2="k_pka_lcc"/>
        <map_variables variable_1="Km_pka_lcc" variable_2="Km_pka_lcc"/>
        <map_variables variable_1="k_pp1_lcc" variable_2="k_pp1_lcc"/>
        <map_variables variable_1="Km_pp1_lcc" variable_2="Km_pp1_lcc"/>
        <map_variables variable_1="k_pp2a_lcc" variable_2="k_pp2a_lcc"/>
        <map_variables variable_1="Km_pp2a_lcc" variable_2="Km_pp2a_lcc"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Nernst_Potentials"/>
        <map_variables variable_1="Temp" variable_2="Temp"/>
        <map_variables variable_1="Na_ext" variable_2="Na_ext"/>
        <map_variables variable_1="K_ext" variable_2="K_ext"/>
        <map_variables variable_1="Ca_ext" variable_2="Ca_ext"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Fast_Na_Current"/>
        <map_variables variable_1="G_Na" variable_2="G_Na"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="L_Type_Calcium_Current"/>
        <map_variables variable_1="K_ext" variable_2="K_ext"/>
        <map_variables variable_1="Ca_ext" variable_2="Ca_ext"/>
        <map_variables variable_1="f" variable_2="f"/>
        <map_variables variable_1="g" variable_2="g"/>
        <map_variables variable_1="gamma_o" variable_2="gamma_o"/>
        <map_variables variable_1="omega" variable_2="omega"/>
        <map_variables variable_1="p_Ca" variable_2="p_Ca"/>
        <map_variables variable_1="p_K" variable_2="p_K"/>
        <map_variables variable_1="N_lcc" variable_2="N_lcc"/>
        <map_variables variable_1="I_Ca05" variable_2="I_Ca05"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Transient_Outward_K_Current"/>
        <map_variables variable_1="G_to" variable_2="G_to"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Steady_State_K_Current"/>
        <map_variables variable_1="G_ss" variable_2="G_ss"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Time_Independent_K_Current"/>
        <map_variables variable_1="G_Ki_bar" variable_2="G_Ki_bar"/>
        <map_variables variable_1="K_ext" variable_2="K_ext"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Plateau_K_Current"/>
        <map_variables variable_1="G_Kp" variable_2="G_Kp"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Na_Ca_Exchanger_Current"/>
        <map_variables variable_1="Na_ext" variable_2="Na_ext"/>
        <map_variables variable_1="Ca_ext" variable_2="Ca_ext"/>
        <map_variables variable_1="k_NaCa" variable_2="k_NaCa"/>
        <map_variables variable_1="Km_Na" variable_2="Km_Na"/>
        <map_variables variable_1="Km_Ca" variable_2="Km_Ca"/>
        <map_variables variable_1="k_sat" variable_2="k_sat"/>
        <map_variables variable_1="eta" variable_2="eta"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Na_K_Pump_Current"/>
        <map_variables variable_1="Na_ext" variable_2="Na_ext"/>
        <map_variables variable_1="K_ext" variable_2="K_ext"/>
        <map_variables variable_1="I_bar_NaK" variable_2="I_bar_NaK"/>
        <map_variables variable_1="Km_Nai" variable_2="Km_Nai"/>
        <map_variables variable_1="Km_Ko" variable_2="Km_Ko"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Sarcolemmal_Ca_Pump_Current"/>
        <map_variables variable_1="I_bar_PCa" variable_2="I_bar_PCa"/>
        <map_variables variable_1="Km_PCa" variable_2="Km_PCa"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Ca_Background_Current"/>
        <map_variables variable_1="G_CaB" variable_2="G_CaB"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Na_Background_Current"/>
        <map_variables variable_1="G_NaB" variable_2="G_NaB"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Calcium_Induced_Calcium_Release"/>
        <map_variables variable_1="tau_on" variable_2="tau_on"/>
        <map_variables variable_1="tau_off" variable_2="tau_off"/>
        <map_variables variable_1="G_max_rel" variable_2="G_max_rel"/>
    </connection>
    <connection>
        <map_components component_1="EC_Coupling_Parameters" component_2="Other_SR_Fluxes_and_Concentrations"/>
        <map_variables variable_1="V_myo" variable_2="V_myo"/>
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