- Author:
- Hanne Nielsen <hnie010@aucklanduni.ac.nz>
- Date:
- 2011-09-13 11:41:40+12:00
- Desc:
- Added session file
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/riccobene_omann_linderman_1999/rawfile/ade691720cc08b4709dac598db6649fe3e1785d3/riccobene_omann_linderman_1999.cellml
<?xml version="1.0"?>
<!-- FILE :riccobene_model_1999.xml
CREATED : 18th October 2002
LAST MODIFIED : 9th April 2003
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Riccobene, Omann and Linderman's 1999 model of the activation and desensitisation of G-protein coupled receptors.
CHANGES:
09/04/2003 - AAC - Added publication date information.
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="riccobene_model_1999" name="riccobene_model_1999">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A Model of Activation and Desensitisation of G-Protein Coupled Receptors</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model has been recoded to remove the reaction element. The model is known to run in both PCEnv and COR to recreate the published results. The units have been checked and are consistent.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Signalling through G-protein coupled receptors is one of the most common and most important methods of transmitting information to the inside of cells. Many mathematical models have been published to describe this type of signal transduction, but the kinetic model described by Riccobene, Omann and Linderman (1999) is unique in that it includes the dynamics of G-protein activation and desensitisation, in addition to considering active and inactive receptor states (see the figure below). The model was used to predict how different ligands would affect the nature of the signal transduction response.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
Modeling Activation and Desensitisation of G-Protein Coupled Receptors Provides Insight into Ligand Efficacy, Todd A. Riccobene, Geneva M. Omann and Jennifer J. Linderman, 1999<emphasis>Journal of Theoretical Biology</emphasis>, 200, 207-222. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10504286&dopt=Abstract">PubMed ID: 10504286</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>diagram of the reaction pathway</title>
</objectinfo>
<imagedata fileref="riccobene_1999.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of Riccobene, Omann and Linderman's model of G-protein coupled receptor signalling. R is the inactive form of the receptor, R* is the active form of the receptor, R<subscript>ds</subscript> is the desensitised form of the receptor, L represents the ligand (in this case, N-formyl-norleucyl-leucyl-phenylalaninyl-nor-leucyl-tyrosyl-lysine-fluorescein, or CHO-NLFNTK-fl), G is the inactive G-protein, G* is the activated G-protein, and LR/LR*/LR<subscript>ds</subscript> represents the ligand/receptor complex in its various forms.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="molar">
<unit units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="first_order_rate_constant">
<unit exponent="-1" units="second"/>
</units>
<units name="second_order_rate_constant">
<unit exponent="-1" units="molar"/>
<unit exponent="-1" units="second"/>
</units>
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</component>
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</apply>
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</math>
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<variable name="R" public_interface="in" units="molar"/>
<variable name="kf" public_interface="in" units="second_order_rate_constant"/>
<variable name="kr" public_interface="in" units="first_order_rate_constant"/>
<variable name="kfR" public_interface="in" units="first_order_rate_constant"/>
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</math>
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<variable cmeta:id="LR_LR" initial_value="0.01" name="LR" public_interface="out" units="molar"/>
<variable name="L" public_interface="in" units="molar"/>
<variable name="R" public_interface="in" units="molar"/>
<variable name="LR_star" public_interface="in" units="molar"/>
<variable name="kf" public_interface="in" units="second_order_rate_constant"/>
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<variable name="kfR" public_interface="in" units="first_order_rate_constant"/>
<variable name="Kact" public_interface="in" units="dimensionless"/>
<variable name="alpha" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
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<variable cmeta:id="LR_ds_LR_ds" initial_value="0.01" name="LR_ds" public_interface="out" units="molar"/>
<variable name="LR_star" public_interface="in" units="molar"/>
<variable name="R_ds" public_interface="in" units="molar"/>
<variable name="L" public_interface="in" units="molar"/>
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<variable name="time" public_interface="in" units="second"/>
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<variable name="LR_ds" public_interface="in" units="molar"/>
<variable name="L" public_interface="in" units="molar"/>
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<variable name="kr2" public_interface="in" units="first_order_rate_constant"/>
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<variable name="LR_star" public_interface="in" units="molar"/>
<variable name="R_star" public_interface="in" units="molar"/>
<variable name="G" public_interface="in" units="molar"/>
<variable name="ka" public_interface="in" units="second_order_rate_constant"/>
<variable name="ki" public_interface="in" units="first_order_rate_constant"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="7">
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<variable name="R_star" public_interface="in" units="molar"/>
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<variable cmeta:id="L_L" initial_value="1E-12" name="L" public_interface="out" units="molar"/>
</component>
<component name="model_parameters">
<variable initial_value="0.37" name="kr" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="8.4E7" name="kf" public_interface="out" units="second_order_rate_constant"/>
<variable initial_value="4.6E-3" name="kr2" public_interface="out" units="first_order_rate_constant"/>
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<map_variables variable_1="kds" variable_2="kds"/>
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<connection>
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<connection>
<map_components component_1="R_ds" component_2="model_parameters"/>
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<connection>
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<connection>
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<connection>
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<map_variables variable_1="ki" variable_2="ki"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#18532679-ce35-4430-8220-b64e0741c197"><Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">10504286</Pubmed_id><JournalArticle xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#4be36544-acbe-4a26-8e5c-dd763a10e299"/></JournalArticle></rdf:Description><rdf:Description rdf:nodeID="n1"><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">60</endingValue></rdf:Description><rdf:Description rdf:about="rdf:#d42abfdc-9c45-4a96-97bf-375a070a7890"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#01fa1d4b-bd26-4e8d-9d65-4a73b058a259"/></creator><rdf:value xml:lang="en">This CellML model has been recoded to remove the reaction element. The model is known to run in both PCEnv and COR to recreate the published results. The units have been checked and are consistent.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#9a64b031-9c45-46fc-9b1c-16a3c094ecbb"><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The Bioengineering Institute</Orgunit><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The University of Auckland</Orgname></rdf:Description><rdf:Description rdf:about="/LR"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">inactive ligand-receptor complex</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">LR</title></rdf:Description><rdf:Description rdf:about="rdf:#6023ea00-8126-4e2b-8db0-4a9c5c27c537"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2003-04-09</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#7fbbb865-ff12-4b38-a059-1d786842a5ca"><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">A</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Todd</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Riccobene</Family></rdf:Description><rdf:Description rdf:about=""><created xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#6fc49f2b-1f6e-42c9-88a9-0eac09522563"/></created><cmeta:modification><rdf:Description rdf:about="rdf:#e5c79db6-4720-452a-b2ab-3834393177d6"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#3075ceb1-2869-4c5c-9941-d490dbb3919b"/></cmeta:modification><cmeta:comment><rdf:Description rdf:about="rdf:#d42abfdc-9c45-4a96-97bf-375a070a7890"/></cmeta:comment><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#85d7c2cf-fd46-4518-886a-e8eb87777697"/></creator><publisher xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">The University of Auckland, Bioengineering Institute</publisher></rdf:Description><rdf:Description rdf:about="/R_ds"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">desensitised receptor </alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">R_ds</title></rdf:Description><rdf:Description rdf:about="/R_star"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">active receptor</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">R_star</title></rdf:Description><rdf:Description rdf:about="rdf:#05f90c91-4e6b-4b9f-ada4-9290667da655"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#9b471836-9e9b-40e0-8939-c200a76ae978"/></subject></rdf:Description><rdf:Description rdf:about="/LR_star"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">active ligand-receptor complex</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">LR_star</title></rdf:Description><rdf:Description rdf:about="rdf:#2b3ae94a-46a6-4bc7-a2f5-d21b26072946"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#5b383b96-b3d8-46d5-9dd5-75435dbd30cf"/></N></rdf:Description><rdf:Description rdf:about="/R"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">inactive receptor</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">R</title></rdf:Description><rdf:Description rdf:about="/G"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">inactive G-protein</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">G</title></rdf:Description><rdf:Description rdf:about="rdf:#9b471836-9e9b-40e0-8939-c200a76ae978"><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type><rdf:value><rdf:Description rdf:nodeID="n2"/></rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#7ed25cda-dc78-4f75-a170-9c8186488b78"><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">A</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Autumn</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Cuellar</Family></rdf:Description><rdf:Description rdf:about="rdf:#a27701cc-2a90-4e8d-a669-06cfbde0af53"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#7ed25cda-dc78-4f75-a170-9c8186488b78"/></N></rdf:Description><rdf:Description rdf:about="rdf:#e5c79db6-4720-452a-b2ab-3834393177d6"><cmeta:modifier><rdf:Description rdf:about="rdf:#c7768eeb-1cca-431a-9232-4ce254286161"/></cmeta:modifier><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#d4c5b081-06d5-460e-87b2-5cea5bb0e502"/></modified><rdf:value xml:lang="en">Recoded model to remove the reaction element.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#a2f946a2-1ed0-4f21-a158-35e5d13f6ec9"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#7492a495-9c28-4978-8a60-9d33aa710eea"/></N></rdf:Description><rdf:Description rdf:about="rdf:#5b383b96-b3d8-46d5-9dd5-75435dbd30cf"><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">M</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Geneva</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Omann</Family></rdf:Description><rdf:Description rdf:nodeID="n3"><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest><rdf:first><rdf:Description rdf:nodeID="n1"/></rdf:first></rdf:Description><rdf:Description rdf:about="rdf:#d4c5b081-06d5-460e-87b2-5cea5bb0e502"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2008-01-03T10:14:55+13:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#4be36544-acbe-4a26-8e5c-dd763a10e299"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Modeling Activation and Desensitisation of G-Protein Coupled
Receptors Provides Insight into Ligand Efficacy</title><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#9d544e26-446c-456c-9e02-53ce6ab84a6d"/></creator><last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">222</last_page><Journal xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#fc205ab8-93fd-4ae8-8916-b05df0ef1f17"/></Journal><issued xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#81d84ae9-afdd-4199-b3ad-6238b9f9e75f"/></issued><first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">207</first_page><volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">200</volume></rdf:Description><rdf:Description rdf:about="rdf:#3075ceb1-2869-4c5c-9941-d490dbb3919b"><cmeta:modifier><rdf:Description rdf:about="rdf:#a27701cc-2a90-4e8d-a669-06cfbde0af53"/></cmeta:modifier><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#6023ea00-8126-4e2b-8db0-4a9c5c27c537"/></modified><rdf:value xml:lang="en">
Added publication date information.
</rdf:value></rdf:Description><rdf:Description rdf:about="#riccobene_model_1999"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">
Riccobene, Omann and Linderman's 1999 model of the activation and
desensitisation of G-protein coupled receptors.
</title><cmeta:comment><rdf:Description rdf:about="rdf:#4c2cf01e-c0d0-4cfa-800d-6aee142e76fd"/></cmeta:comment><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#18532679-ce35-4430-8220-b64e0741c197"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#05f90c91-4e6b-4b9f-ada4-9290667da655"/></reference><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n4"/></simulation></rdf:Description><rdf:Description rdf:about="rdf:#c7768eeb-1cca-431a-9232-4ce254286161"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#237aaefb-a81b-4ee9-ba75-72e355f0c22e"/></N></rdf:Description><rdf:Description rdf:about="/LR_ds"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">desensitised ligand-receptor complex</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">LR_ds</title></rdf:Description><rdf:Description rdf:about="rdf:#66e078e9-d9bc-4f90-89d9-d7e36677f1f8"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#7fbbb865-ff12-4b38-a059-1d786842a5ca"/></N></rdf:Description><rdf:Description rdf:about="rdf:#ba4f6070-afa5-45d8-94a3-60fa227d0423"><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type><rdf:value xml:lang="en">c.lloyd@auckland.ac.nz</rdf:value></rdf:Description><rdf:Description rdf:about="/G_star"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">activated G-protein</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">G_star</title></rdf:Description><rdf:Description rdf:about="rdf:#9d544e26-446c-456c-9e02-53ce6ab84a6d"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type><rdf:_2><rdf:Description rdf:about="rdf:#2b3ae94a-46a6-4bc7-a2f5-d21b26072946"/></rdf:_2><rdf:_3><rdf:Description rdf:about="rdf:#a2f946a2-1ed0-4f21-a158-35e5d13f6ec9"/></rdf:_3><rdf:_1><rdf:Description rdf:about="rdf:#66e078e9-d9bc-4f90-89d9-d7e36677f1f8"/></rdf:_1></rdf:Description><rdf:Description rdf:about="rdf:#237aaefb-a81b-4ee9-ba75-72e355f0c22e"><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family></rdf:Description><rdf:Description rdf:about="rdf:#85d7c2cf-fd46-4518-886a-e8eb87777697"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#5bba625c-411c-48e0-9728-73798f2500f6"/></N><ORG xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#9a64b031-9c45-46fc-9b1c-16a3c094ecbb"/></ORG><EMAIL xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#ba4f6070-afa5-45d8-94a3-60fa227d0423"/></EMAIL></rdf:Description><rdf:Description rdf:nodeID="n2"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/></rdf:type><rdf:_6 xml:lang="en">g-protein</rdf:_6><rdf:_2 xml:lang="en">desensitisation</rdf:_2><rdf:_3 xml:lang="en">efficacy</rdf:_3><rdf:_1 xml:lang="en">pharmacology</rdf:_1><rdf:_5 xml:lang="en">gpcr</rdf:_5><rdf:_4 xml:lang="en">signal transduction</rdf:_4></rdf:Description><rdf:Description rdf:about="rdf:#01fa1d4b-bd26-4e8d-9d65-4a73b058a259"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine Lloyd</FN></rdf:Description><rdf:Description rdf:about="rdf:#7492a495-9c28-4978-8a60-9d33aa710eea"><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">J</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Jennifer</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Linderman</Family></rdf:Description><rdf:Description rdf:about="rdf:#8e6f410f-6021-4e1a-8247-33abf42b6e55"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine Lloyd</FN></rdf:Description><rdf:Description rdf:about="rdf:#5bba625c-411c-48e0-9728-73798f2500f6"><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family></rdf:Description><rdf:Description rdf:about="rdf:#6fc49f2b-1f6e-42c9-88a9-0eac09522563"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2002-10-18T00:00:00+00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#fc205ab8-93fd-4ae8-8916-b05df0ef1f17"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Journal of Theoretical Biology</title></rdf:Description><rdf:Description rdf:about="rdf:#81d84ae9-afdd-4199-b3ad-6238b9f9e75f"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">1999-09-21</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#4c2cf01e-c0d0-4cfa-800d-6aee142e76fd"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#8e6f410f-6021-4e1a-8247-33abf42b6e55"/></creator><rdf:value xml:lang="en">This is the CellML descripition of Riccobene, Omann and Linderman's
1999 model of the activation and desensitisation of G-protein coupled
receptors.</rdf:value></rdf:Description><rdf:Description rdf:nodeID="n4"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n3"/></boundIntervals></rdf:Description><rdf:Description rdf:about="/L"><alternative xmlns="http://purl.org/dc/terms/" xml:lang="en">ligand</alternative><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">L</title></rdf:Description></rdf:RDF></model>
