Location: Purvis, Butera, 2005 @ 4c10e77f7b64 / purvis_butera_2005.cellml

Author:

rcai987 <devnull@localhost>

Date:

2015-02-12 13:46:40+13:00

Desc:

Added annotations to purvis_butera_2005.cellml

Permanent Source URI:

https://models.physiomeproject.org/workspace/purvis_butera_2005/rawfile/4c10e77f7b64e797dd1ef39ce819f78a0cce00a9/purvis_butera_2005.cellml

<?xml version="1.0"?>
<!--
This CellML file was generated on 21/07/2008 at 9:20:03 at a.m. using:

COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.CellML.org/
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	<documentation xmlns="http://cellml.org/tmp-documentation">
		<article>
			<articleinfo>
				<title>Ionic current model of a hypoglossal motoneuron</title>
				<author>
					<firstname>Geoffrey</firstname>
					<surname>Nunns</surname>
					<affiliation>
						<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>
            This CellML model is known to run in both OpenCell and COR and the units have been checked and are consistent. The model recreates the published results. 
          </para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
				<para>
ABSTRACT: We have developed a single-compartment, electrophysiological, hypoglossal motoneuron (HM) model based primarily on experimental data from neonatal rat HMs. The model is able to reproduce the fine features of the HM action potential: the fast afterhyperpolarization, the afterdepolarization, and the medium-duration afterhyperpolarization (mAHP). The model also reproduces the repetitive firing properties seen in neonatal HMs and replicates the neuron's response to pharmacological experiments. The model was used to study the role of specific ionic currents in HM firing and how variations in the densities of these currents may account for age-dependent changes in excitability seen in HMs. By varying the density of a fast inactivating calcium current, the model alternates between accelerating and adapting firing patterns. Modeling the age-dependent increase in H current density accounts for the decrease in mAHP duration observed experimentally, but does not fully account for the decrease in input resistance. An increase in the density of the voltage-dependent potassium currents and the H current is required to account for the decrease in input resistance. These changes also account for the age-dependent decrease in action potential duration.
</para>
			
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  <imageobject>
    <objectinfo>
      <title>model diagram</title>
    </objectinfo>
    <imagedata fileref="purvis_2005.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram of the cell model.  It is composed of ten ionic currents across the plasma membrane: a fast sodium current, INa; a delayed rectifier potassium current, IK; a persistent sodium current,  INaP; a passive leakage current, IL; a LVA calcium current, IT; an N-type HVA calcium current, IN; a P-type HVA calcium current, IP; a calcium-dependent potassium current, ISK; a fast-transient potassium current, IA; and finally, a hyperpolarisation-activated current, IH.</caption>
</informalfigure>

<para>				
The original paper reference is cited below:
</para>
				<para>
Ionic current model of a hypoglossal motoneuron, Robert J. Butera, Jr., Liston K. Purvis, 2005, <emphasis>Journal of Neurophysiology</emphasis>, 93, 723-733.   <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=15653786&amp;dopt=Abstract">PubMed ID: 15653786</ulink>
				</para>
				
			</sect1>
		</article>
	</documentation>   
	
	
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      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_leak</ci>
            <apply>
               <times/>
               <ci>g_leak</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_leak</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00058" name="LVA_calcium_current">
      <variable cmeta:id="LVA_calcium_current_i_T" name="i_T" public_interface="out" units="nanoA"/>
      <variable cmeta:id="id_00060" initial_value="0.1" name="g_T" units="uS"/>
      <variable cmeta:id="id_00061" initial_value="40" name="E_Ca" public_interface="out" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable cmeta:id="id_00062" name="m" private_interface="in" units="dimensionless"/>
      <variable cmeta:id="id_00063" name="h" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_T</ci>
            <apply>
               <times/>
               <ci>g_T</ci>
               <ci>m</ci>
               <ci>h</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00064" name="LVA_calcium_current_m_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable cmeta:id="id_00065" initial_value="0.001" name="m" public_interface="out" units="dimensionless"/>
      <variable cmeta:id="id_00066" initial_value="38" name="theta_m" units="millivolt"/>
      <variable cmeta:id="id_00067" initial_value="5" name="sigma_m" units="millivolt"/>
      <variable cmeta:id="id_00068" initial_value="28" name="theta_1" units="millivolt"/>
      <variable cmeta:id="id_00069" initial_value="25" name="sigma_1" units="millivolt"/>
      <variable cmeta:id="id_00070" initial_value="70" name="sigma_2" units="millivolt"/>
      <variable cmeta:id="id_00071" name="tau_m" units="millisecond"/>
      <variable cmeta:id="id_00072" name="m_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_m</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">5</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <ci>theta_1</ci>
                           </apply>
                           <ci>sigma_1</ci>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <ci>theta_1</ci>
                              </apply>
                           </apply>
                           <ci>sigma_2</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>m_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <ci>theta_m</ci>
                           </apply>
                        </apply>
                        <ci>sigma_m</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>m_infinity</ci>
                  <ci>m</ci>
               </apply>
               <ci>tau_m</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00073" name="LVA_calcium_current_h_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable cmeta:id="id_00074" initial_value="0.562" name="h" public_interface="out" units="dimensionless"/>
      <variable cmeta:id="id_00075" initial_value="70.1" name="theta_h" units="millivolt"/>
      <variable cmeta:id="id_00076" initial_value="7" name="sigma_h" units="millivolt"/>
      <variable cmeta:id="id_00077" initial_value="70" name="theta_1" units="millivolt"/>
      <variable cmeta:id="id_00078" initial_value="65" name="sigma_1" units="millivolt"/>
      <variable cmeta:id="id_00079" name="tau_h" units="millisecond"/>
      <variable cmeta:id="id_00080" name="h_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_h</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">20</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <ci>theta_1</ci>
                           </apply>
                           <ci>sigma_1</ci>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <ci>theta_1</ci>
                              </apply>
                           </apply>
                           <ci>sigma_1</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>h_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <ci>theta_h</ci>
                        </apply>
                        <ci>sigma_h</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>h_infinity</ci>
                  <ci>h</ci>
               </apply>
               <ci>tau_h</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00081" name="N_HVA_calcium_current">
      <variable cmeta:id="N_HVA_calcium_current_i_N" name="i_N" public_interface="out" units="nanoA"/>
      <variable cmeta:id="id_00083" initial_value="0.05" name="g_N" units="uS"/>
      <variable cmeta:id="id_00084" name="E_Ca" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable cmeta:id="id_00085" name="m" private_interface="in" units="dimensionless"/>
      <variable cmeta:id="id_00086" name="h" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_N</ci>
            <apply>
               <times/>
               <ci>g_N</ci>
               <ci>m</ci>
               <ci>h</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00087" name="N_HVA_calcium_current_m_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable cmeta:id="id_00088" initial_value="0.001" name="m" public_interface="out" units="dimensionless"/>
      <variable cmeta:id="id_00089" initial_value="30" name="theta_m" units="millivolt"/>
      <variable cmeta:id="id_00090" initial_value="6" name="sigma_m" units="millivolt"/>
      <variable cmeta:id="id_00091" initial_value="5" name="tau_m" units="millisecond"/>
      <variable cmeta:id="id_00092" name="m_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>m_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <ci>theta_m</ci>
                           </apply>
                        </apply>
                        <ci>sigma_m</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>m_infinity</ci>
                  <ci>m</ci>
               </apply>
               <ci>tau_m</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00093" name="N_HVA_calcium_current_h_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable cmeta:id="id_00094" initial_value="0.649" name="h" public_interface="out" units="dimensionless"/>
      <variable cmeta:id="id_00095" initial_value="70" name="theta_h" units="millivolt"/>
      <variable cmeta:id="id_00096" initial_value="3" name="sigma_h" units="millivolt"/>
      <variable cmeta:id="id_00097" initial_value="25" name="tau_h" units="millisecond"/>
      <variable cmeta:id="id_00098" name="h_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>h_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <ci>theta_h</ci>
                        </apply>
                        <ci>sigma_h</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>h_infinity</ci>
                  <ci>h</ci>
               </apply>
               <ci>tau_h</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="P_HVA_calcium_current">
      <variable cmeta:id="P_HVA_calcium_current_i_P" name="i_P" public_interface="out" units="nanoA"/>
      <variable initial_value="0.05" name="g_P" units="uS"/>
      <variable name="E_Ca" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_P</ci>
            <apply>
               <times/>
               <ci>g_P</ci>
               <ci>m</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00099" name="P_HVA_calcium_current_m_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable cmeta:id="id_00100" initial_value="0" name="m" public_interface="out" units="dimensionless"/>
      <variable cmeta:id="id_00101" initial_value="17" name="theta_m" units="millivolt"/>
      <variable cmeta:id="id_00102" initial_value="3" name="sigma_m" units="millivolt"/>
      <variable cmeta:id="id_00103" initial_value="10" name="tau_m" units="millisecond"/>
      <variable cmeta:id="id_00104" name="m_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>m_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <ci>theta_m</ci>
                           </apply>
                        </apply>
                        <ci>sigma_m</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>m_infinity</ci>
                  <ci>m</ci>
               </apply>
               <ci>tau_m</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00106" name="calcium_dependent_potassium_current">
      <variable cmeta:id="calcium_dependent_potassium_current_i_SK" name="i_SK" public_interface="out" units="nanoA"/>
      <variable cmeta:id="id_00107" initial_value="0.3" name="g_SK" units="uS"/>
      <variable cmeta:id="id_00108" name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="i_T" private_interface="out" public_interface="in" units="nanoA"/>
      <variable name="i_N" private_interface="out" public_interface="in" units="nanoA"/>
      <variable name="i_P" private_interface="out" public_interface="in" units="nanoA"/>
      <variable name="z" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_SK</ci>
            <apply>
               <times/>
               <ci>g_SK</ci>
               <apply>
                  <power/>
                  <ci>z</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00110" name="calcium_dependent_potassium_current_z_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="i_T" public_interface="in" units="nanoA"/>
      <variable name="i_N" public_interface="in" units="nanoA"/>
      <variable name="i_P" public_interface="in" units="nanoA"/>
      <variable initial_value="0" name="z" public_interface="out" units="dimensionless"/>
      <variable initial_value="-500" name="K1" units="uM_per_nanocoulomb"/>
      <variable initial_value="0.04" name="K2" units="per_ms"/>
      <variable initial_value="0.0604" name="Ca_conc" units="uM"/>
      <variable initial_value="1" name="tau_z" units="millisecond"/>
      <variable name="z_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_conc</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1000</cn>
                  </apply>
                  <ci>K1</ci>
                  <apply>
                     <plus/>
                     <ci>i_T</ci>
                     <ci>i_N</ci>
                     <ci>i_P</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>K2</ci>
                  <ci>Ca_conc</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>z_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uM">0.003</cn>
                        <ci>Ca_conc</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>z</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>z_infinity</ci>
                  <ci>z</ci>
               </apply>
               <ci>tau_z</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00111" name="fast_transient_potassium_current">
      <variable cmeta:id="fast_transient_potassium_current_i_A" name="i_A" public_interface="out" units="nanoA"/>
      <variable cmeta:id="id_00113" initial_value="1" name="g_A" units="uS"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <variable name="h" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_A</ci>
            <apply>
               <times/>
               <ci>g_A</ci>
               <ci>m</ci>
               <ci>h</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00114" name="fast_transient_potassium_current_m_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable initial_value="0.057" name="m" public_interface="out" units="dimensionless"/>
      <variable initial_value="27" name="theta_m" units="millivolt"/>
      <variable initial_value="16" name="sigma_m" units="millivolt"/>
      <variable initial_value="40" name="theta_1" units="millivolt"/>
      <variable initial_value="74" name="theta_2" units="millivolt"/>
      <variable initial_value="5" name="sigma_1" units="millivolt"/>
      <variable initial_value="7.5" name="sigma_2" units="millivolt"/>
      <variable name="tau_m" units="millisecond"/>
      <variable name="m_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_m</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <ci>theta_1</ci>
                           </apply>
                           <ci>sigma_1</ci>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <ci>theta_2</ci>
                              </apply>
                           </apply>
                           <ci>sigma_2</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.37</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>m_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <ci>theta_m</ci>
                           </apply>
                        </apply>
                        <ci>sigma_m</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>m_infinity</ci>
                  <ci>m</ci>
               </apply>
               <ci>tau_m</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component cmeta:id="id_00115" name="fast_transient_potassium_current_h_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable initial_value="0.287" name="h" public_interface="out" units="dimensionless"/>
      <variable initial_value="80" name="theta_h" units="millivolt"/>
      <variable initial_value="11" name="sigma_h" units="millivolt"/>
      <variable initial_value="20" name="tau_h" units="millisecond"/>
      <variable name="h_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>h_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
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                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <ci>theta_h</ci>
                        </apply>
                        <ci>sigma_h</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
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               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>h_infinity</ci>
                  <ci>h</ci>
               </apply>
               <ci>tau_h</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="hyperpolarization_activated_current">
      <variable cmeta:id="hyperpolarization_activated_current_i_H" name="i_H" public_interface="out" units="nanoA"/>
      <variable initial_value="0.005" name="g_H" units="uS"/>
      <variable initial_value="-38.8" name="E_H" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_H</ci>
            <apply>
               <times/>
               <ci>g_H</ci>
               <ci>m</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_H</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="hyperpolarization_activated_current_m_gate">
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable initial_value="0.182" name="m" public_interface="out" units="dimensionless"/>
      <variable initial_value="79.8" name="theta_m" units="millivolt"/>
      <variable initial_value="5.3" name="sigma_m" units="millivolt"/>
      <variable initial_value="70" name="theta_1" units="millivolt"/>
      <variable initial_value="11" name="sigma_1" units="millivolt"/>
      <variable name="tau_m" units="millisecond"/>
      <variable name="m_infinity" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_m</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <ci>theta_1</ci>
                           </apply>
                           <ci>sigma_1</ci>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <ci>theta_1</ci>
                              </apply>
                           </apply>
                           <ci>sigma_1</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">50</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>m_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <ci>theta_m</ci>
                        </apply>
                        <ci>sigma_m</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>m_infinity</ci>
                  <ci>m</ci>
               </apply>
               <ci>tau_m</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="stimulus_protocol">
      <variable name="i_app" public_interface="out" units="nanoA"/>
      <variable initial_value="10" name="i_stimStart" units="millisecond"/>
      <variable initial_value="11" name="i_stimEnd" units="millisecond"/>
      <variable initial_value="10" name="i_stimAmplitude" units="nanoA"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_app</ci>
            <piecewise>
               <piece>
                  <ci>i_stimAmplitude</ci>
                  <apply>
                     <and/>
                     <apply>
                        <geq/>
                        <ci>time</ci>
                        <ci>i_stimStart</ci>
                     </apply>
                     <apply>
                        <leq/>
                        <ci>time</ci>
                        <ci>i_stimEnd</ci>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA">0</cn>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="sodium_current">
         <component_ref component="sodium_current_h_gate"/>
         <component_ref component="sodium_current_m_gate"/>
      </component_ref>
      <component_ref component="persistent_sodium_current">
         <component_ref component="persistent_sodium_current_h_gate"/>
         <component_ref component="persistent_sodium_current_m_gate"/>
      </component_ref>
      <component_ref component="delayed_rectifier_current">
         <component_ref component="delayed_rectifier_current_n_gate"/>
      </component_ref>
      <component_ref component="LVA_calcium_current">
         <component_ref component="LVA_calcium_current_h_gate"/>
         <component_ref component="LVA_calcium_current_m_gate"/>
      </component_ref>
      <component_ref component="N_HVA_calcium_current">
         <component_ref component="N_HVA_calcium_current_h_gate"/>
         <component_ref component="N_HVA_calcium_current_m_gate"/>
      </component_ref>
      <component_ref component="P_HVA_calcium_current">
         <component_ref component="P_HVA_calcium_current_m_gate"/>
      </component_ref>
      <component_ref component="calcium_dependent_potassium_current">
         <component_ref component="calcium_dependent_potassium_current_z_gate"/>
      </component_ref>
      <component_ref component="fast_transient_potassium_current">
         <component_ref component="fast_transient_potassium_current_h_gate"/>
         <component_ref component="fast_transient_potassium_current_m_gate"/>
      </component_ref>
      <component_ref component="hyperpolarization_activated_current">
         <component_ref component="hyperpolarization_activated_current_m_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="environment" component_2="membrane"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="sodium_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="persistent_sodium_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="delayed_rectifier_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="leak_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="LVA_calcium_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="N_HVA_calcium_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="P_HVA_calcium_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="calcium_dependent_potassium_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="fast_transient_potassium_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="hyperpolarization_activated_current"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="stimulus_protocol"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="stimulus_protocol"/>
      <map_variables variable_1="i_app" variable_2="i_app"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="sodium_current" component_2="sodium_current_h_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="h" variable_2="h"/>
   </connection>
   <connection>
      <map_components component_1="sodium_current" component_2="sodium_current_m_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="m" variable_2="m"/>
   </connection>
   <connection>
      <map_components component_1="sodium_current" component_2="persistent_sodium_current"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="persistent_sodium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaP" variable_2="i_NaP"/>
   </connection>
   <connection>
      <map_components component_1="persistent_sodium_current" component_2="persistent_sodium_current_h_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="h" variable_2="h"/>
   </connection>
   <connection>
      <map_components component_1="persistent_sodium_current" component_2="persistent_sodium_current_m_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="m" variable_2="m"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="delayed_rectifier_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K" variable_2="i_K"/>
   </connection>
   <connection>
      <map_components component_1="delayed_rectifier_current" component_2="delayed_rectifier_current_n_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="n" variable_2="n"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="leak_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_leak" variable_2="i_leak"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="LVA_calcium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_T" variable_2="i_T"/>
   </connection>
   <connection>
      <map_components component_1="LVA_calcium_current" component_2="LVA_calcium_current_m_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="m" variable_2="m"/>
   </connection>
   <connection>
      <map_components component_1="LVA_calcium_current" component_2="LVA_calcium_current_h_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="h" variable_2="h"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="N_HVA_calcium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_N" variable_2="i_N"/>
   </connection>
   <connection>
      <map_components component_1="N_HVA_calcium_current" component_2="N_HVA_calcium_current_m_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="m" variable_2="m"/>
   </connection>
   <connection>
      <map_components component_1="N_HVA_calcium_current" component_2="N_HVA_calcium_current_h_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="h" variable_2="h"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="P_HVA_calcium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_P" variable_2="i_P"/>
   </connection>
   <connection>
      <map_components component_1="P_HVA_calcium_current" component_2="P_HVA_calcium_current_m_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="m" variable_2="m"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_dependent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_SK" variable_2="i_SK"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dependent_potassium_current" component_2="calcium_dependent_potassium_current_z_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="z" variable_2="z"/>
      <map_variables variable_1="i_T" variable_2="i_T"/>
      <map_variables variable_1="i_N" variable_2="i_N"/>
      <map_variables variable_1="i_P" variable_2="i_P"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dependent_potassium_current" component_2="LVA_calcium_current"/>
      <map_variables variable_1="i_T" variable_2="i_T"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dependent_potassium_current" component_2="N_HVA_calcium_current"/>
      <map_variables variable_1="i_N" variable_2="i_N"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dependent_potassium_current" component_2="P_HVA_calcium_current"/>
      <map_variables variable_1="i_P" variable_2="i_P"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="fast_transient_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_A" variable_2="i_A"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_potassium_current" component_2="fast_transient_potassium_current_m_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="m" variable_2="m"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_potassium_current" component_2="fast_transient_potassium_current_h_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="h" variable_2="h"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="hyperpolarization_activated_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_H" variable_2="i_H"/>
   </connection>
   <connection>
      <map_components component_1="hyperpolarization_activated_current" component_2="hyperpolarization_activated_current_m_gate"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="m" variable_2="m"/>
   </connection>
   <connection>
      <map_components component_1="LVA_calcium_current" component_2="N_HVA_calcium_current"/>
      <map_variables variable_1="E_Ca" variable_2="E_Ca"/>
   </connection>
   <connection>
      <map_components component_1="LVA_calcium_current" component_2="P_HVA_calcium_current"/>
      <map_variables variable_1="E_Ca" variable_2="E_Ca"/>
   </connection>
   <connection>
      <map_components component_1="delayed_rectifier_current" component_2="calcium_dependent_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="delayed_rectifier_current" component_2="fast_transient_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
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<rdf:RDF><rdf:Description rdf:about="rdf:#8e14cbcc-bc57-4317-9e24-ebd4347a4e46"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type><rdf:_1><rdf:Description rdf:about="rdf:#8064ac21-2949-4e87-9fa8-f729a740f420"/></rdf:_1><rdf:_2><rdf:Description rdf:about="rdf:#08f6a2e0-d600-4562-8f94-5e66935d181b"/></rdf:_2></rdf:Description><rdf:Description rdf:about="rdf:#8064ac21-2949-4e87-9fa8-f729a740f420"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><vCard:N><rdf:Description rdf:about="rdf:#20e3d890-971f-4ebb-897d-f976ff672ad5"/></vCard:N></rdf:Description><rdf:Description rdf:about="rdf:#08f6a2e0-d600-4562-8f94-5e66935d181b"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><vCard:N><rdf:Description rdf:about="rdf:#caedb363-aa2a-4436-973d-9b52337c6496"/></vCard:N></rdf:Description><rdf:Description rdf:about="rdf:#c0088db1-41dc-4390-825a-e26b99d7866a"><dcterms:W3CDTF xml:lang="en">2005-00-00 00:00</dcterms:W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#20e3d890-971f-4ebb-897d-f976ff672ad5"><vCard:Given xml:lang="en">Liston</vCard:Given><vCard:Family xml:lang="en">Purvis</vCard:Family><vCard:Other xml:lang="en">K</vCard:Other></rdf:Description><rdf:Description rdf:about="#butera_purvis_2004"><cmeta:comment><rdf:Description rdf:about="rdf:#1cdf0fd5-4def-4837-8e9b-c9151a7dbcd8"/></cmeta:comment><bqs:reference><rdf:Description rdf:about="rdf:#7e841777-6b49-4615-a4ca-99b21ed06167"/></bqs:reference><bqs:reference><rdf:Description rdf:nodeID="n1"/></bqs:reference><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:about="rdf:#$JLJmU3"/></simulation></rdf:Description><rdf:Description rdf:about="rdf:#7e841777-6b49-4615-a4ca-99b21ed06167"><bqs:Pubmed_id xml:lang="en">15653786</bqs:Pubmed_id><bqs:JournalArticle><rdf:Description rdf:about="rdf:#674118a8-ef6f-4f7d-a45a-9fbd12836428"/></bqs:JournalArticle></rdf:Description><rdf:Description rdf:about="rdf:#1cdf0fd5-4def-4837-8e9b-c9151a7dbcd8"><dc:creator><rdf:Description rdf:about="rdf:#0577c35b-ff0b-43c0-967f-770bc039908e"/></dc:creator><rdf:value xml:lang="en">This CellML model is known to run in both PCEnv and COR and the units have been checked and are consistent. The model recreates the published results.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#caedb363-aa2a-4436-973d-9b52337c6496"><vCard:Given xml:lang="en">Robert</vCard:Given><vCard:Family xml:lang="en">Butera</vCard:Family><vCard:Other xml:lang="en">J</vCard:Other></rdf:Description><rdf:Description rdf:about="rdf:#593d0aac-2849-4182-80cc-41ed4138b925"><dc:title xml:lang="en">Journal of Neurophysiology</dc:title></rdf:Description><rdf:Description rdf:about="rdf:#$LLJmU3"><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">60</endingValue><pointDensity xmlns="http://www.cellml.org/metadata/simulation/1.0#nonstandard-" xml:lang="en">10000</pointDensity><maximumStepSize xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">0.01</maximumStepSize></rdf:Description><rdf:Description rdf:about="rdf:#0577c35b-ff0b-43c0-967f-770bc039908e"><vCard:FN xml:lang="en">Geoff Nunns</vCard:FN></rdf:Description><rdf:Description 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