Mathematical Model Of An Adult Human Atrial Cell, 1998
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This model has been curated and unit checked and is known to run and produce the correct output in PCEnv and COR.
Model Structure
Over the past decade, extensive voltage-clamp and action potential data from human atrial myocytes have been published from a number of laboratories. Based on these experimental data, A. Nygren, C. Fiset, L. Firek, J.W. Clark, D.S. Lindblad, R.B. Clark and W.R. Giles have published a mathematical model of the electrophysiological responses of a representative human atrial cell. Their model is sufficiently accurate to have predictive capabilities for selected aspects of the electrophysiological responses in the human atrium. Emphasis has been placed on the functional roles of the K+ currents during repolarisation.
The mathematical model is based on the classical formulation of Hodgkin and Huxley (see The Hodgkin-Huxley Squid Axon Model, 1952). Ionic currents through the sarcolemma are coupled with a fluid compartment model (see the figure below), which accounts for changes in ionic concentrations in the cytoplasm and sarcoplasmic reticulum.
The complete original paper reference is cited below:
Mathematical Model of an Adult Human Atrial Cell: The Role of K+ Currents in Repolarization, A Nygren, C. Fiset, L. Firek, J.W. Clark, D.S. Lindblad, R.B. Clark and W.R. Giles, 1998,
Circulation Research
, 82, 63-81. (Full text and PDF versions of the article are available for Journal Members on the Circulation Research website.) PubMed ID: 9440706
fluid compartment model of a human atrial cell
A fluid compartment model of the human atrial cell, including intracellular, cleft and extracellular spaces.
9440706
The University of Auckland, Bioengineering Institute
R
Clark
B
A
Nygren
Dr. Daniel Ziemek noted that the model had two bugs in it. Those were, that the variable gCaL should be 6.75 instead of 3, and also that the stimulus amplitude should have been -280 pA instead of 400. These values were changed by Penny Noble, who sent James Lawson the file. James Lawson then made a few modifications to allow the file to be run in PCEnv as well as COR.
2006-03-31
W
Giles
R
unknown
100000
0.001
J
Clark
W
This is the CellML description of Nygren et al's mathematical model
of an adult human atrial cell. They specifically study the role of K+ currents in repolarisation.
Catherine Lloyd
2002-05-23T00:00:00+00:00
2007-04-03
2007-08-17T13:21:40+12:00
c.lloyd@auckland.ac.nz
James
Lawson
Richard
The University of Auckland
The Bioengineering Institute
L
Firek
James Lawson
added metadata
This model has been curated by Penny Noble and James Lawson and is known to run and produce the correct output in PCEnv and COR.
keyword
k+ currents
Atrial Myocyte
atrial myocyte
electrophysiology
human
cardiac
Mathematical Model of an Adult Human Atrial Cell: The Role of K+ Currents in Repolarization
82
63
81
2008-02-25T11:36:41+13:00
unknown
unknown
Peter
Villiger
J
C
Fiset
unknown
unknown
unknown
1998-01-01
Circulation Research
D
Lindblad
S
Units checked, curated
Catherine
Lloyd
May
Penny
Noble
J