A Model for Restriction Point Control of the Mammalian Cell Cycle
Jeelean
Lim
Bioengineering Institute, University of Auckland
Model Status
This CellML version of the model runs in PCEnv but in order to reproduce the published results, requires initial concentrations that are not listed in the paper. The switch "mass = mass/2 when Cdh1 crosses 0.2 from below" has not been implemented in this CellML description.
ValidateCellML verifies this model as valid CellML.
Model Structure
ABSTRACT: Inhibition of protein synthesis by cycloheximide blocks subsequent division of a mammalian cell, but only if the cell is exposed to
the drug before the restriction point (i.e. within the first several hours after birth). If exposed to cycloheximide after the restriction
point, a cell proceeds with DNA synthesis, mitosis and cell division and halts in the next cell cycle. If cycloheximide is later removed
from the culture medium, treated cells will return to the division cycle, showing a complex pattern of division times post-treatment,
as first measured by Zetterberg and colleagues.
We simulate these physiological responses of mammalian cells to transient inhibition
of growth, using a set of nonlinear differential equations based on a realistic model of the molecular events underlying progression
through the cell cycle. The model relieson our earlier work on the regulation of cyclin-dependent protein kinases during the cell
division cycle of yeast. The yeast model is supplemented with equations describing the effects of retinoblastoma protein on cell
growth and the synthesis of cyclins A and E, and with a primitive representation of the signaling pathway that controls synthesis of
cyclin D.
The complete original paper reference is cited below:
A model for restriction point control of the mammalian cell cycle, Bela Novak, and John J Tyson, 2004,
Journal of Theoretical Biology
, 230, 563-579. (A PDF version of the article is available to subscribers on the Journal of Theoretical Biology website.) PubMed ID: 15363676
figure 1
Molecular network regulating the progression of mammalian cells through the cell cycle.
2004-10-21 00:00
Jeelean Lim
This is the CellML description of Novak and Tyson's 2004 model for restriction point control of the mammalian cell cycle.
15363676
Jeelean Lim
Journal of Theoretical Biology
Jeelean
Lim
Updated curation status, removed reference link from documentation
A model for restriction point control of the mammalian cell cycle
230
563
579
2009-05-14T15:04:45+12:00
keyword
cell cycle
Bela
Novak
James
Lawson
Richard
2009-02-19T00:00:00+00:00
This CellML version of the model runs in PCEnv but in order to reproduce the published results, requires initial concentrations that are not listed in the paper. The switch "mass = mass/2 when Cdh1 crosses 0.2 from below" has not been implemented in this CellML description. Units have been checked and are consistent.
University of Auckland
Auckland Bioengineering Institute
John
Tyson
jlim063@aucklanduni.ac.nz