Modelling the Interellations Between Calcium Oscillations and ER Membrane Potential Oscillations
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
Model Structure
Oscillations in the cytosolic calcium concentration ([Ca2+]i), in the form of repetitive spikes, may be stimulated by hormones or neurotransmitters in a variety of cell types, including hepatocytes, oocytes, cardiomyocytes and fibroblasts. It is generally accepted that the mechanism underlying these calcium oscillations is related to the calcium-induced calcium release (CICR) mechanism. Often, secondary messengers such as inositol 1,4,5-trisphosphate (IP3) are also involved. Calcium oscillations play a role in the regulation of cell excretion, muscle contraction, activation of mammalian oocytes, call signalling and other cellular activities.
Calcium oscillations and their underlying molecular mechanisms have been the subject of interest for several mathematical models, including:
Li and Rinzel, IP3-Mediated Ca2+ Oscillations - A Simplified Model, 1994;
D. Friel, [Ca2+]i Oscillations in in Sympathetic Neurons, 1995;
Chay et al., Intracellular Calcium Spikes in Non-Excitable Cells, 1995; and
Keizer and Levine, RyR Adaptation and Ca2+ Oscillations, 1996.
In the Marhl et al. 1997 publication described here, the authors present an electrochemical model which accounts for intracellular calcium oscillations and their interrelations with oscillations of the potential difference across the membrane of the endoplasmic reticulum (ER) or other inracellular calium stores (see below). The model shows tht when a calcium buffering system such as calmodulin is included, calcium oscillations can arise without a permanent influx of calium into the cell.
The model has been described here in CellML (the raw CellML description of the Marhl et al. 1997 model can be downloaded in various formats as described in ).
The complete original paper reference is cited below:
Modelling the interellations between calcium oscillations and ER membrane potential oscillations, Marko Marhl, Stefan Schuster, Milan Brumen, and Reinhart Heinrich, 1997, Biophysical Chemistry, 63, 221-239. PubMed ID: 12362939
cell diagram
Schematic diagram of the model system.
calcium dynamics
electrophysiology
oscillator
1997-01-31
Modelling the interrelations between calcium oscillations and ER membrane potential oscillations
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Marhl et al's 1997 model of the interrelations between calcium oscillations and ER membrane potential oscillations.
2004-01-21
Catherine
Lloyd
May
12362939
The University of Auckland
The Bioengineering Institute
Reinhart
Heinrich
BioSystems
Catherine Lloyd
c.lloyd@auckland.ac.nz
The University of Auckland, Bioengineering Institute
keyword
Marko
Marhl
Stefan
Schuster
Milan
Brumen
This is the CellML description of Marhl et al's
1997 model of the interrelations between calcium oscillations and ER membrane potential oscillations.