Luo-Rudy Mammalian Ventricular Model I 1991
Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This model has been curated and unit checked and is known to replicate the published results in OpenCell and COR.
Model Structure
In 1991, Ching-hsing Luo and Yoram Rudy published a mathematical model of the ventricular cardiac action potential. This original model is the first of the two Luo-Rudy models, and it has subsequently come to be known as the Luo-Rudy I model. It is a significant update of the Beeler-Reuter mammalian ventricular model (1977) (see the figure below), and like the the Beeler-Reuter model, the Luo-Rudy I model uses Hodgkin-Huxley type equations to calculate ionic currents.
The complete original paper reference is cited below:
A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction, Ching-hsing Luo and Yoram Rudy, 1991 Circulation Research, 68, 1501-1526. PubMed ID: 1709839
cell diagram of the LR-I model showing ionic currents, pumps and exchangers within the sarcolemma
A schematic diagram describing the current flows across the cell membrane that are captured in the LR-I model.
Y
Rudy
Added a repeating stimulus protocol using the stimulus duration (2ms) and amplitude (-25.5 microA_per_cm2) used for the original single stimulus.
Added a repeating stimulus protocol using the stimulus duration (2ms) and amplitude (-25.5 microA_per_cm2) used for the original single stimulus.
The University of Auckland, Bioengineering Institute
1709839
This is the CellML description of Luo and Rudy's mathematical model of the membrane action potential of the mammalian ventricular cell. It describes six ionic currents and it is a development of the Beeler-Reuter 1977 mammalian ventricular model, using Hodgkin-Huxley type equations.
James
Lawson
Richard
2006-03-31
Catherine
Lloyd
May
James
Lawson
Richard
2008-02-25T11:01:56+13:00
keyword
Ventricular Myocyte
cardiac
electrophysiology
ventricular myocyte
2001-09-15T00:00:00+00:00
1991-01-01
C
Luo
H
Penny
Noble
J
A Model of the Ventricular Cardiac Action Potential. Depolarization, repolarization and their interaction
68(6)
1501
1526
Circulation Research
Units checked, curated. Some cmeta:id's added to variables to allow referencing by PCEnv session file
2007-08-17T12:59:52+12:00
Peter
Villiger
J
James Lawson
c.lloyd@auckland.ac.nz
This model has had a repeating current stimulus protocol added to allow it to simulate trains of action potentials. This model is known to run in PCEnv and produce the correct output.
Catherine Lloyd
added metadata
The University of Auckland
The Bioengineering Institute
2007-08-17T12:59:52+12:00
10000