- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2010-04-27 14:01:42+12:00
- Desc:
- Remade sessio nfile with integrated clickable SVG
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/iyer_mazhari_winslow_2004/rawfile/2d04beaa020c4636b58625f49892271e44eb5a06/iyer_mazhari_winslow_2004.cellml
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COR (0.9.31.833)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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<title>A computational model of the human left-ventricular epicardial myocyte</title>
<author>
<firstname>Steven</firstname>
<surname>Niederer</surname>
<affiliation>
<shortaffil>Department of Physiology, Anatomy and Genetics, Oxford University</shortaffil>
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<section id="sec_status">
<title>Model Status</title>
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This CellML model runs in OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.
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<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: A computational model of the human left-ventricular epicardial myocyte is presented. Models of each of the major ionic currents present in these cells are formulated and validated using experimental data obtained from studies of recombinant human ion channels and/or whole-cell recording from single myocytes isolated from human left-ventricular subepicardium. Continuous-time Markov chain models for the gating of the fast Na(+) current, transient outward current, rapid component of the delayed rectifier current, and the L-type calcium current are modified to represent human data at physiological temperature. A new model for the gating of the slow component of the delayed rectifier current is formulated and validated against experimental data. Properties of calcium handling and exchanger currents are altered to appropriately represent the dynamics of intracellular ion concentrations. The model is able to both reproduce and predict a wide range of behaviors observed experimentally including action potential morphology, ionic currents, intracellular calcium transients, frequency dependence of action-potential duration, Ca(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation. The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
A computational model of the human left-ventricular epicardial myocyte, Vivek Iyer, Reza Mazhari and Raimond L. Winslow, 2004, <emphasis>Biophysical Journal</emphasis>, 87, 1507-1525. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/15345532">PubMed ID: 15345532</ulink>
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<caption>A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Iyer <emphasis>et al.</emphasis> 2004 mathematical model of the human left-ventricular epicardial myocyte.</caption>
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<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CMDNtot" initial_value="50e-3" name="CMDNtot" units="mM"/>
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CSQNtot" initial_value="15e0" name="CSQNtot" units="mM"/>
<variable initial_value="0e0" name="EGTAtot" units="mM"/>
<variable initial_value="2.38e-3" name="KmCMDN" units="mM"/>
<variable initial_value="0.8e0" name="KmCSQN" units="mM"/>
<variable initial_value="1.5e-4" name="KmEGTA" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="dLTRPNCa" units="per_ms"/>
<variable name="dHTRPNCa" units="per_ms"/>
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_Jtrpn" name="Jtrpn" public_interface="out" units="mM_per_ms"/>
<variable name="CaSS" public_interface="in" units="mM"/>
<variable name="beta_SS" public_interface="out" units="dimensionless"/>
<variable name="beta_JSR" public_interface="out" units="dimensionless"/>
<variable name="beta_i" public_interface="out" units="dimensionless"/>
<variable name="CaJSR" public_interface="in" units="mM"/>
<variable initial_value="0.8046584973e-1" name="LTRPNCa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.9772152481" name="HTRPNCa" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dLTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kltrpn_plus</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dHTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>khtrpn_plus</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>khtrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>dLTRPNCa</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>dHTRPNCa</ci>
</apply>
<apply>
<eq/>
<ci>Jtrpn</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>LTRPNtot</ci>
<ci>dLTRPNCa</ci>
</apply>
<apply>
<times/>
<ci>HTRPNtot</ci>
<ci>dHTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_SS</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaSS</ci>
<ci>KmCMDN</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaSS</ci>
<ci>KmEGTA</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_JSR</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQNtot</ci>
<ci>KmCSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaJSR</ci>
<ci>KmCSQN</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>KmCMDN</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>KmEGTA</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES">
<variable initial_value="0.01215" name="kaplus" units="per_uM4_per_ms"/>
<variable initial_value="0.576" name="kaminus" units="per_ms"/>
<variable initial_value="0.00405" name="kbplus" units="per_uM3_per_ms"/>
<variable initial_value="1.93" name="kbminus" units="per_ms"/>
<variable initial_value="0.1" name="kcplus" units="per_ms"/>
<variable initial_value="0.0008" name="kcminus" units="per_ms"/>
<variable initial_value="4" name="ncoop" units="dimensionless"/>
<variable initial_value="3" name="mcoop" units="dimensionless"/>
<variable name="CaSS" public_interface="in" units="mM"/>
<variable name="dC1_RyR" units="per_ms"/>
<variable name="dO2_RyR" units="per_ms"/>
<variable name="dC2_RyR" units="per_ms"/>
<variable name="dO1_RyR" units="per_ms"/>
<variable name="time" public_interface="in" units="ms"/>
<variable initial_value="0.4448038946" name="C1_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.397392006e-8" name="O2_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.554535924" name="C2_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.6601783287e-3" name="O1_RyR" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dC1_RyR</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>kaplus</ci>
</apply>
<apply>
<power/>
<apply>
<times/>
<ci>CaSS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="m2u">1000</cn>
</apply>
<ci>ncoop</ci>
</apply>
<ci>C1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kaminus</ci>
<ci>O1_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dO2_RyR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kbplus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>CaSS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="m2u">1000</cn>
</apply>
<ci>mcoop</ci>
</apply>
<ci>O1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kbminus</ci>
<ci>O2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dC2_RyR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kcplus</ci>
<ci>O1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kcminus</ci>
<ci>C2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dO1_RyR</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>dC1_RyR</ci>
<ci>dO2_RyR</ci>
<ci>dC2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1_RyR</ci>
</apply>
<ci>dC1_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2_RyR</ci>
</apply>
<ci>dO2_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2_RyR</ci>
</apply>
<ci>dC2_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1_RyR</ci>
</apply>
<ci>dO1_RyR</ci>
</apply>
</math>
</component>
<component name="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES">
<variable initial_value="0.3" name="fL" units="per_ms"/>
<variable initial_value="4" name="gL" units="per_ms"/>
<variable initial_value="2" name="bL" units="dimensionless"/>
<variable initial_value="2" name="aL" units="dimensionless"/>
<variable name="C0_to_C1" units="per_ms"/>
<variable name="C1_to_C2" units="per_ms"/>
<variable name="C2_to_C3" units="per_ms"/>
<variable name="C3_to_C4" units="per_ms"/>
<variable name="C1_to_C0" units="per_ms"/>
<variable name="C2_to_C1" units="per_ms"/>
<variable name="C3_to_C2" units="per_ms"/>
<variable name="C4_to_C3" units="per_ms"/>
<variable name="CCa0_to_CCa1" units="per_ms"/>
<variable name="CCa1_to_CCa2" units="per_ms"/>
<variable name="CCa2_to_CCa3" units="per_ms"/>
<variable name="CCa3_to_CCa4" units="per_ms"/>
<variable name="CCa1_to_CCa0" units="per_ms"/>
<variable name="CCa2_to_CCa1" units="per_ms"/>
<variable name="CCa3_to_CCa2" units="per_ms"/>
<variable name="CCa4_to_CCa3" units="per_ms"/>
<variable name="C0_to_CCa0" units="per_ms"/>
<variable name="C1_to_CCa1" units="per_ms"/>
<variable name="C2_to_CCa2" units="per_ms"/>
<variable name="C3_to_CCa3" units="per_ms"/>
<variable name="C4_to_CCa4" units="per_ms"/>
<variable name="CCa0_to_C0" units="per_ms"/>
<variable name="CCa1_to_C1" units="per_ms"/>
<variable name="CCa2_to_C2" units="per_ms"/>
<variable name="CCa3_to_C3" units="per_ms"/>
<variable name="CCa4_to_C4" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="alpha" units="per_ms"/>
<variable name="beta" units="per_ms"/>
<variable name="alpha_prime" units="per_ms"/>
<variable name="beta_prime" units="per_ms"/>
<variable name="gamma" units="per_ms"/>
<variable name="omega" units="per_ms"/>
<variable name="a1_Ca0" units="per_ms"/>
<variable name="a2_Ca0" units="per_ms"/>
<variable name="a1_Ca1" units="per_ms"/>
<variable name="a2_Ca1" units="per_ms"/>
<variable name="a1_Ca2" units="per_ms"/>
<variable name="a2_Ca2" units="per_ms"/>
<variable name="a1_Ca3" units="per_ms"/>
<variable name="a2_Ca3" units="per_ms"/>
<variable name="a1_Ca4" units="per_ms"/>
<variable name="a2_Ca4" units="per_ms"/>
<variable name="a1_C0" units="per_ms"/>
<variable name="a2_C0" units="per_ms"/>
<variable name="a1_C1" units="per_ms"/>
<variable name="a2_C1" units="per_ms"/>
<variable name="a1_C2" units="per_ms"/>
<variable name="a2_C2" units="per_ms"/>
<variable name="a1_C3" units="per_ms"/>
<variable name="a2_C3" units="per_ms"/>
<variable name="a1_C4" units="per_ms"/>
<variable name="a2_C4" units="per_ms"/>
<variable name="CaSS" public_interface="in" units="mM"/>
<variable initial_value="0.8621934054" name="C0" units="dimensionless"/>
<variable initial_value="0.01141398211" name="C1" units="dimensionless"/>
<variable initial_value="5.666325225e-5" name="C2" units="dimensionless"/>
<variable initial_value="1.25021357e-7" name="C3" units="dimensionless"/>
<variable initial_value="1.034426748e-10" name="C4" units="dimensionless"/>
<variable initial_value="0.1198547081" name="CCa0" units="dimensionless"/>
<variable initial_value="0.006346794302" name="CCa1" units="dimensionless"/>
<variable initial_value="1.260326488e-4" name="CCa2" units="dimensionless"/>
<variable initial_value="1.112315238e-6" name="CCa3" units="dimensionless"/>
<variable initial_value="3.681315892e-9" name="CCa4" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable initial_value="7.757981563e-12" name="Open" public_interface="out" units="dimensionless"/>
<variable initial_value="0.9997157074" name="yCa" public_interface="out" units="dimensionless"/>
<variable name="a1_Cainf" units="dimensionless"/>
<variable name="yCa_inf" units="dimensionless"/>
<variable name="tau_yCa" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">4</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.416</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.012</cn>
<apply>
<minus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">35</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">4</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.45</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.049</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.065</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">22</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_prime</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_prime</ci>
<apply>
<divide/>
<ci>beta</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.6</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mM">0.09233</cn>
<ci>CaSS</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>omega</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.25</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>C0_to_C1</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C1_to_C2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_C3</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_C4</ci>
<ci>alpha</ci>
</apply>
<apply>
<eq/>
<ci>CCa0_to_CCa1</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa1_to_CCa2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_CCa3</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_CCa4</ci>
<ci>alpha_prime</ci>
</apply>
<apply>
<eq/>
<ci>C1_to_C0</ci>
<ci>beta</ci>
</apply>
<apply>
<eq/>
<ci>C2_to_C1</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_C2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_to_C3</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa1_to_CCa0</ci>
<ci>beta_prime</ci>
</apply>
<apply>
<eq/>
<ci>CCa2_to_CCa1</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_CCa2</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa4_to_CCa3</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C0_to_CCa0</ci>
<ci>gamma</ci>
</apply>
<apply>
<eq/>
<ci>C1_to_CCa1</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C0_to_CCa0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_CCa2</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C1_to_CCa1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_CCa3</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C2_to_CCa2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_to_CCa4</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C3_to_CCa3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa0_to_C0</ci>
<ci>omega</ci>
</apply>
<apply>
<eq/>
<ci>CCa1_to_C1</ci>
<apply>
<divide/>
<ci>CCa0_to_C0</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_C2</ci>
<apply>
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<ci>alpha_act14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2Kv14_to_C3Kv14</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>alpha_act14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3Kv14_to_OKv14</ci>
<ci>alpha_act14</ci>
</apply>
<apply>
<eq/>
<ci>CI0Kv14_to_CI1Kv14</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>b1Kv14</ci>
<ci>alpha_act14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI1Kv14_to_CI2Kv14</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
<ci>b2Kv14</ci>
<ci>alpha_act14</ci>
</apply>
<ci>b1Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI2Kv14_to_CI3Kv14</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>b3Kv14</ci>
<ci>alpha_act14</ci>
</apply>
<ci>b2Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI3Kv14_to_OIKv14</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>b4Kv14</ci>
<ci>alpha_act14</ci>
</apply>
<ci>b3Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C1Kv14_to_C0Kv14</ci>
<ci>beta_act14</ci>
</apply>
<apply>
<eq/>
<ci>C2Kv14_to_C1Kv14</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>beta_act14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3Kv14_to_C2Kv14</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
<ci>beta_act14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>OKv14_to_C3Kv14</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>beta_act14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI1Kv14_to_CI0Kv14</ci>
<apply>
<divide/>
<ci>beta_act14</ci>
<ci>f1Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI2Kv14_to_CI1Kv14</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>f1Kv14</ci>
<ci>beta_act14</ci>
</apply>
<ci>f2Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI3Kv14_to_CI2Kv14</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
<ci>f2Kv14</ci>
<ci>beta_act14</ci>
</apply>
<ci>f3Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>OIKv14_to_CI3Kv14</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>f3Kv14</ci>
<ci>beta_act14</ci>
</apply>
<ci>f4Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C0Kv14_to_CI0Kv14</ci>
<ci>beta_inact14</ci>
</apply>
<apply>
<eq/>
<ci>C1Kv14_to_CI1Kv14</ci>
<apply>
<times/>
<ci>f1Kv14</ci>
<ci>beta_inact14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2Kv14_to_CI2Kv14</ci>
<apply>
<times/>
<ci>f2Kv14</ci>
<ci>beta_inact14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3Kv14_to_CI3Kv14</ci>
<apply>
<times/>
<ci>f3Kv14</ci>
<ci>beta_inact14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>OKv14_to_OIKv14</ci>
<apply>
<times/>
<ci>f4Kv14</ci>
<ci>beta_inact14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI0Kv14_to_C0Kv14</ci>
<ci>alpha_inact14</ci>
</apply>
<apply>
<eq/>
<ci>CI1Kv14_to_C1Kv14</ci>
<apply>
<divide/>
<ci>alpha_inact14</ci>
<ci>b1Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI2Kv14_to_C2Kv14</ci>
<apply>
<divide/>
<ci>alpha_inact14</ci>
<ci>b2Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CI3Kv14_to_C3Kv14</ci>
<apply>
<divide/>
<ci>alpha_inact14</ci>
<ci>b3Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>OIKv14_to_OKv14</ci>
<apply>
<divide/>
<ci>alpha_inact14</ci>
<ci>b4Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C0</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C0Kv14_to_C1Kv14</ci>
<ci>C0Kv14_to_CI0Kv14</ci>
</apply>
<ci>C0Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C0</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C1Kv14_to_C0Kv14</ci>
<ci>C1Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI0Kv14_to_C0Kv14</ci>
<ci>CI0Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_C0</ci>
<ci>a1_C0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C1</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C1Kv14_to_C2Kv14</ci>
<ci>C1Kv14_to_C0Kv14</ci>
<ci>C1Kv14_to_CI1Kv14</ci>
</apply>
<ci>C1Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C2Kv14_to_C1Kv14</ci>
<ci>C2Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI1Kv14_to_C1Kv14</ci>
<ci>CI1Kv14</ci>
</apply>
<apply>
<times/>
<ci>C0Kv14_to_C1Kv14</ci>
<ci>C0Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_C1</ci>
<ci>a1_C1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C2</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C2Kv14_to_C3Kv14</ci>
<ci>C2Kv14_to_C1Kv14</ci>
<ci>C2Kv14_to_CI2Kv14</ci>
</apply>
<ci>C2Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C3Kv14_to_C2Kv14</ci>
<ci>C3Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI2Kv14_to_C2Kv14</ci>
<ci>CI2Kv14</ci>
</apply>
<apply>
<times/>
<ci>C1Kv14_to_C2Kv14</ci>
<ci>C1Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_C2</ci>
<ci>a1_C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C3</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C3Kv14_to_OKv14</ci>
<ci>C3Kv14_to_C2Kv14</ci>
<ci>C3Kv14_to_CI3Kv14</ci>
</apply>
<ci>C3Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C3</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>OKv14_to_C3Kv14</ci>
<ci>OKv14</ci>
</apply>
<apply>
<times/>
<ci>CI3Kv14_to_C3Kv14</ci>
<ci>CI3Kv14</ci>
</apply>
<apply>
<times/>
<ci>C2Kv14_to_C3Kv14</ci>
<ci>C2Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_C3</ci>
<ci>a1_C3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_O</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>OKv14_to_C3Kv14</ci>
<ci>OKv14_to_OIKv14</ci>
</apply>
<ci>OKv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_O</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C3Kv14_to_OKv14</ci>
<ci>C3Kv14</ci>
</apply>
<apply>
<times/>
<ci>OIKv14_to_OKv14</ci>
<ci>OIKv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OKv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_O</ci>
<ci>a1_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_CI0</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI0Kv14_to_C0Kv14</ci>
<ci>CI0Kv14_to_CI1Kv14</ci>
</apply>
<ci>CI0Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_CI0</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C0Kv14_to_CI0Kv14</ci>
<ci>C0Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI1Kv14_to_CI0Kv14</ci>
<ci>CI1Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI0Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_CI0</ci>
<ci>a1_CI0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_CI1</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI1Kv14_to_CI2Kv14</ci>
<ci>CI1Kv14_to_C1Kv14</ci>
<ci>CI1Kv14_to_CI0Kv14</ci>
</apply>
<ci>CI1Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_CI1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>CI2Kv14_to_CI1Kv14</ci>
<ci>CI2Kv14</ci>
</apply>
<apply>
<times/>
<ci>C1Kv14_to_CI1Kv14</ci>
<ci>C1Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI0Kv14_to_CI1Kv14</ci>
<ci>CI0Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_CI1</ci>
<ci>a1_CI1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_CI2</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI2Kv14_to_CI3Kv14</ci>
<ci>CI2Kv14_to_C2Kv14</ci>
<ci>CI2Kv14_to_CI1Kv14</ci>
</apply>
<ci>CI2Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_CI2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>CI3Kv14_to_CI2Kv14</ci>
<ci>CI3Kv14</ci>
</apply>
<apply>
<times/>
<ci>C2Kv14_to_CI2Kv14</ci>
<ci>C2Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI1Kv14_to_CI2Kv14</ci>
<ci>CI1Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_CI2</ci>
<ci>a1_CI2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_CI3</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI3Kv14_to_OIKv14</ci>
<ci>CI3Kv14_to_C3Kv14</ci>
<ci>CI3Kv14_to_CI2Kv14</ci>
</apply>
<ci>CI3Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_CI3</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>OIKv14_to_CI3Kv14</ci>
<ci>OIKv14</ci>
</apply>
<apply>
<times/>
<ci>C3Kv14_to_CI3Kv14</ci>
<ci>C3Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI2Kv14_to_CI3Kv14</ci>
<ci>CI2Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_CI3</ci>
<ci>a1_CI3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_OI</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>OIKv14_to_OKv14</ci>
<ci>OIKv14_to_CI3Kv14</ci>
</apply>
<ci>OIKv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_OI</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>OKv14_to_OIKv14</ci>
<ci>OKv14</ci>
</apply>
<apply>
<times/>
<ci>CI3Kv14_to_OIKv14</ci>
<ci>CI3Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OIKv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_OI</ci>
<ci>a1_OI</ci>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_REVERSAL_POTENTIALS">
<variable name="ENa" public_interface="out" units="mV"/>
<variable name="EK" public_interface="out" units="mV"/>
<variable name="EKs" public_interface="out" units="mV"/>
<variable name="ECa" public_interface="out" units="mV"/>
<variable name="RT_over_F" public_interface="in" units="mV"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="a1" units="mM"/>
<variable name="a2" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ENa</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EK</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1</ci>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01833</cn>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01833</cn>
<ci>Nai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EKs</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>a1</ci>
<ci>a2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ECa</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp">
<variable initial_value="0.0186e0" name="GKr" units="mS_per_uF"/>
<variable initial_value="0.0035e0" name="GKs" units="mS_per_uF"/>
<variable initial_value="0.1253051261188079722568586886469e0" name="GK1" units="mS_per_uF"/>
<variable initial_value="56.32e0" name="GNa" units="mS_per_uF"/>
<variable initial_value="0.001e0" name="GNab" units="mS_per_uF"/>
<variable initial_value="0.872" name="KvScale" units="dimensionless"/>
<variable initial_value="0.889" name="Kv43Frac" units="dimensionless"/>
<variable name="GKv43" units="mS_per_uF"/>
<variable name="PKv14" units="litre_per_farad_second"/>
<variable name="OKv14" public_interface="in" units="dimensionless"/>
<variable name="na6" public_interface="in" units="dimensionless"/>
<variable name="na7" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="ENa" public_interface="in" units="mV"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="OHerg" public_interface="in" units="dimensionless"/>
<variable name="O1ks" public_interface="in" units="dimensionless"/>
<variable name="O2ks" public_interface="in" units="dimensionless"/>
<variable name="OKv43" public_interface="in" units="dimensionless"/>
<variable name="RT_over_F" public_interface="in" units="mV"/>
<variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="EK" public_interface="in" units="mV"/>
<variable name="fKo" units="dimensionless"/>
<variable name="VF_over_RT" units="dimensionless"/>
<variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
<variable name="a1_K" units="mM"/>
<variable name="a2" units="dimensionless"/>
<variable name="a1_Na" units="mM"/>
<variable name="K1_inf" units="dimensionless"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKr" name="IKr" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKs" name="IKs" public_interface="out" units="uA_per_uF"/>
<variable name="IKv43" public_interface="out" units="uA_per_uF"/>
<variable name="IKv14_K" public_interface="out" units="uA_per_uF"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="IKv14_Na" public_interface="out" units="uA_per_uF"/>
<variable name="IKv14" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_Ito1" name="Ito1" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IK1" name="IK1" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INab" name="INab" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INa" name="INa" public_interface="out" units="uA_per_uF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PKv14</ci>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>Kv43Frac</ci>
</apply>
<ci>KvScale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second">4.2986<sep/>-7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>GKv43</ci>
<apply>
<times/>
<ci>Kv43Frac</ci>
<ci>KvScale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mS_per_uF">0.1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>INa</ci>
<apply>
<times/>
<ci>GNa</ci>
<apply>
<plus/>
<ci>na6</ci>
<ci>na7</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fKo</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">4</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IKr</ci>
<apply>
<times/>
<ci>GKr</ci>
<ci>fKo</ci>
<ci>OHerg</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IKs</ci>
<apply>
<times/>
<ci>GKs</ci>
<apply>
<plus/>
<ci>O1ks</ci>
<ci>O2ks</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IKv43</ci>
<apply>
<times/>
<ci>GKv43</ci>
<ci>OKv43</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>VFsq_over_RT</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn>
<ci>Faraday</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<minus/>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>IKv14_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>PKv14</ci>
<ci>OKv14</ci>
<ci>VFsq_over_RT</ci>
<ci>a1_K</ci>
</apply>
<ci>a2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Na</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Nai</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>IKv14_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
<ci>PKv14</ci>
<ci>OKv14</ci>
<ci>VFsq_over_RT</ci>
<ci>a1_Na</ci>
</apply>
<ci>a2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>IKv14</ci>
<apply>
<plus/>
<ci>IKv14_K</ci>
<ci>IKv14_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ito1</ci>
<apply>
<plus/>
<ci>IKv43</ci>
<ci>IKv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>K1_inf</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.94</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.26</cn>
<ci>RT_over_F</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IK1</ci>
<apply>
<times/>
<ci>GK1</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
</apply>
<ci>K1_inf</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INab</ci>
<apply>
<times/>
<ci>GNab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_INaK_INaCa_ICab_IpCa">
<variable name="V" public_interface="in" units="mV"/>
<variable name="ECa" public_interface="in" units="mV"/>
<variable name="RT_over_F" public_interface="in" units="mV"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable initial_value="0.44" name="kNaCa" units="uA_per_uF"/>
<variable initial_value="87.5" name="KmNa" units="mM"/>
<variable initial_value="1.38" name="KmCa" units="mM"/>
<variable initial_value="0.2" name="ksat" units="dimensionless"/>
<variable initial_value="0.35" name="eta" units="dimensionless"/>
<variable initial_value="2.387" name="INaKmax" units="uA_per_uF"/>
<variable initial_value="20" name="KmNai" units="mM"/>
<variable initial_value="1.5" name="KmKo" units="mM"/>
<variable initial_value="0.05" name="IpCamax" units="uA_per_uF"/>
<variable initial_value="0.0005" name="KmpCa" units="mM"/>
<variable initial_value="7.684e-5" name="GCab" units="mS_per_uF"/>
<variable name="VF_over_RT" units="dimensionless"/>
<variable name="sigma" units="dimensionless"/>
<variable name="a1_Na" units="dimensionless"/>
<variable name="a2_Na" units="dimensionless"/>
<variable name="fNaK" units="dimensionless"/>
<variable name="a1_K" units="dimensionless"/>
<variable name="a2_K" units="dimensionless"/>
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaK" name="INaK" public_interface="out" units="uA_per_uF"/>
<variable name="a1_ncx" units="mM4"/>
<variable name="a2_ncx" units="mM4"/>
<variable name="a3_ncx" units="dimensionless"/>
<variable name="a4_ncx" units="mM"/>
<variable name="a5_ncx" units="mM3"/>
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaCa" name="INaCa" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_ICab" name="ICab" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_IpCa" name="IpCa" public_interface="out" units="uA_per_uF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ICab</ci>
<apply>
<times/>
<ci>GCab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ECa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IpCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>IpCamax</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>KmpCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Na</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Na</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.33</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fNaK</ci>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>a1_Na</ci>
<ci>a2_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<divide/>
<ci>Ko</ci>
<apply>
<plus/>
<ci>Ko</ci>
<ci>KmKo</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_K</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>KmNai</ci>
<ci>Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INaK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>INaKmax</ci>
<ci>fNaK</ci>
<ci>a1_K</ci>
</apply>
<ci>a2_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_ncx</ci>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<ci>eta</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_ncx</ci>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a3_ncx</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>ksat</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a4_ncx</ci>
<apply>
<plus/>
<ci>KmCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a5_ncx</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<power/>
<ci>KmNa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5000</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>INaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kNaCa</ci>
<apply>
<minus/>
<ci>a1_ncx</ci>
<ci>a2_ncx</ci>
</apply>
</apply>
<apply>
<times/>
<ci>a4_ncx</ci>
<ci>a3_ncx</ci>
<ci>a5_ncx</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_ICa_ICaK">
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="RT_over_F" public_interface="in" units="mV"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="yCa" public_interface="in" units="dimensionless"/>
<variable name="Open" public_interface="in" units="dimensionless"/>
<variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
<variable name="PKprime" units="litre_per_farad_second"/>
<variable name="VF_over_RT" units="dimensionless"/>
<variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
<variable name="a1_Ca" units="mM"/>
<variable name="a2_Ca" units="dimensionless"/>
<variable name="a1_K" units="mM"/>
<variable name="a2_K" units="dimensionless"/>
<variable name="ICa" public_interface="out" units="uA_per_uF"/>
<variable name="ICaK" public_interface="out" units="uA_per_uF"/>
<variable name="ICamax" units="uA_per_uF"/>
<variable name="Icabar" units="uA_per_uF"/>
<variable name="PCa" units="litre_per_farad_second"/>
<variable name="PK" units="litre_per_farad_second"/>
<variable initial_value="-0.265" name="ICahalf" units="uA_per_uF"/>
<variable initial_value="7" name="Pscale" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PK</ci>
<apply>
<times/>
<ci>Pscale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second">4.574<sep/>-7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>PCa</ci>
<apply>
<times/>
<ci>Pscale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second">2.469<sep/>-4</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>VFsq_over_RT</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn>
<ci>Faraday</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Ca</ci>
<apply>
<minus/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mM">1.0<sep/>-3</cn>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Cao</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.341</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Ca</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ICamax</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>PCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>VFsq_over_RT</ci>
<ci>a1_Ca</ci>
</apply>
<ci>a2_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ICa</ci>
<apply>
<times/>
<ci>ICamax</ci>
<ci>yCa</ci>
<ci>Open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Icabar</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA_per_uF">0</cn>
<apply>
<geq/>
<ci>ICamax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA_per_uF">0</cn>
</apply>
</piece>
<otherwise>
<ci>ICamax</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>PKprime</ci>
<apply>
<divide/>
<ci>PK</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Icabar</ci>
<ci>ICahalf</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_K</ci>
<apply>
<minus/>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ICaK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>PKprime</ci>
<ci>Open</ci>
<ci>yCa</ci>
<ci>VFsq_over_RT</ci>
<ci>a1_K</ci>
</apply>
<ci>a2_K</ci>
</apply>
</apply>
</math>
</component>
<component name="INa">
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Temp_Scale" units="dimensionless"/>
<variable name="alpha1" units="per_ms"/>
<variable name="beta1" units="per_ms"/>
<variable name="gamma1" units="per_ms"/>
<variable name="Delta1" units="per_ms"/>
<variable name="On" units="per_ms"/>
<variable name="Of" units="per_ms"/>
<variable name="GammaGamma" units="per_ms"/>
<variable name="DeltaDelta" units="per_ms"/>
<variable name="epsilon" units="per_ms"/>
<variable name="omega_na" units="per_ms"/>
<variable name="rho" units="per_ms"/>
<variable name="mu" units="per_ms"/>
<variable name="Cn" units="per_ms"/>
<variable name="Cf" units="per_ms"/>
<variable name="parameter_a" units="dimensionless"/>
<variable name="k12" units="per_ms"/>
<variable name="k23" units="per_ms"/>
<variable name="k34" units="per_ms"/>
<variable name="k45" units="per_ms"/>
<variable name="k56" units="per_ms"/>
<variable name="k67" units="per_ms"/>
<variable name="k89" units="per_ms"/>
<variable name="k910" units="per_ms"/>
<variable name="k1011" units="per_ms"/>
<variable name="k1112" units="per_ms"/>
<variable name="k1213" units="per_ms"/>
<variable name="k57" units="per_ms"/>
<variable name="k21" units="per_ms"/>
<variable name="k32" units="per_ms"/>
<variable name="k43" units="per_ms"/>
<variable name="k54" units="per_ms"/>
<variable name="k65" units="per_ms"/>
<variable name="k76" units="per_ms"/>
<variable name="k98" units="per_ms"/>
<variable name="k109" units="per_ms"/>
<variable name="k1110" units="per_ms"/>
<variable name="k1211" units="per_ms"/>
<variable name="k1312" units="per_ms"/>
<variable name="k75" units="per_ms"/>
<variable name="k81" units="per_ms"/>
<variable name="k92" units="per_ms"/>
<variable name="k103" units="per_ms"/>
<variable name="k114" units="per_ms"/>
<variable name="k125" units="per_ms"/>
<variable name="k136" units="per_ms"/>
<variable name="k18" units="per_ms"/>
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<variable name="k310" units="per_ms"/>
<variable name="k411" units="per_ms"/>
<variable name="k512" units="per_ms"/>
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<variable initial_value="0.1437575649" name="na1" public_interface="out" units="dimensionless"/>
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<variable initial_value="4.005266484e-6" name="na5" public_interface="out" units="dimensionless"/>
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<divide/>
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<minus/>
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<apply>
<eq/>
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<times/>
<ci>Temp_Scale</ci>
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<exp/>
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<plus/>
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<divide/>
<apply>
<minus/>
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<divide/>
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<times/>
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<ci>V</ci>
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<apply>
<eq/>
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<times/>
<ci>Temp_Scale</ci>
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<exp/>
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<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">133689.9304091</cn>
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<ci>RTNa</ci>
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<divide/>
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<ci>Rgas</ci>
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<apply>
<divide/>
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<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.55804214553883</cn>
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<ci>V</ci>
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<apply>
<eq/>
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<times/>
<ci>Temp_Scale</ci>
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<exp/>
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<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">62123.0784380481</cn>
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<ci>RTNa</ci>
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<divide/>
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<ci>Rgas</ci>
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<divide/>
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<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.288816042743232</cn>
<ci>V</ci>
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<apply>
<eq/>
<ci>Of</ci>
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<times/>
<ci>Temp_Scale</ci>
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<exp/>
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<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">97657.8497137015</cn>
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<ci>RTNa</ci>
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<divide/>
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<ci>Rgas</ci>
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<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0684861993100685</cn>
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<apply>
<eq/>
<ci>GammaGamma</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">116431.142142348</cn>
<ci>RTNa</ci>
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<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">578.317</cn>
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<ci>Rgas</ci>
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<apply>
<divide/>
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<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.764126011745707</cn>
<ci>V</ci>
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<apply>
<eq/>
<ci>DeltaDelta</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
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<apply>
<exp/>
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<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">55700.6624658307</cn>
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<apply>
<minus/>
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<ci>Rgas</ci>
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<apply>
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<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.64981672927078</cn>
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<ci>V</ci>
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<apply>
<eq/>
<ci>epsilon</ci>
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<times/>
<ci>Temp_Scale</ci>
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<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">85800.3675578326</cn>
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<ci>Rgas</ci>
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<apply>
<eq/>
<ci>omega_na</ci>
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<times/>
<ci>Temp_Scale</ci>
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<exp/>
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<plus/>
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<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">121955.166154864</cn>
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<ci>Rgas</ci>
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<apply>
<eq/>
<ci>rho</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
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<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">147813.990005035</cn>
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<apply>
<divide/>
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<ci>Rgas</ci>
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<divide/>
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<times/>
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<ci>V</ci>
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<apply>
<eq/>
<ci>mu</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
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<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">121322.143275242</cn>
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<ci>RTNa</ci>
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<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">193.265</cn>
<ci>Rgas</ci>
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<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.74290267020903</cn>
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<ci>V</ci>
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<apply>
<eq/>
<ci>Cn</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
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<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">287913.446530953</cn>
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<ci>RTNa</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">786.217</cn>
<ci>Rgas</ci>
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<apply>
<eq/>
<ci>Cf</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
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<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">59565.2236284584</cn>
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<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">0.00711</cn>
<ci>Rgas</ci>
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<ci>parameter_a</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
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<eq/>
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<eq/>
<ci>k67</ci>
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<eq/>
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<times/>
<ci>k12</ci>
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<eq/>
<ci>k910</ci>
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<times/>
<ci>k23</ci>
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<times/>
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<ci>k1112</ci>
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<times/>
<ci>k45</ci>
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<apply>
<eq/>
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<eq/>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
<ci>beta1</ci>
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<ci>beta1</ci>
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<apply>
<eq/>
<ci>k65</ci>
<ci>Delta1</ci>
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<eq/>
<ci>k76</ci>
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<eq/>
<ci>k98</ci>
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<eq/>
<ci>k109</ci>
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<eq/>
<ci>k1110</ci>
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<eq/>
<ci>k1211</ci>
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<eq/>
<ci>k1312</ci>
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<eq/>
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<eq/>
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<eq/>
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<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#a9ab6f8f-e029-4e60-8241-15b9316961f1"><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type><rdf:value xml:lang="en">sn@dpag.ox.ac.uk</rdf:value></rdf:Description><rdf:Description rdf:nodeID="n1"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/></rdf:type><rdf:_2 xml:lang="en">Ventricular Myocyte</rdf:_2><rdf:_1 xml:lang="en">excitation-contraction coupling</rdf:_1><rdf:_5 xml:lang="en">ventricular myocyte</rdf:_5><rdf:_3 xml:lang="en">epicardial myocyte</rdf:_3><rdf:_6 xml:lang="en">electrophysiology</rdf:_6><rdf:_4 xml:lang="en">calcium dynamics</rdf:_4><rdf:_7 xml:lang="en">cardiac</rdf:_7></rdf:Description><rdf:Description rdf:nodeID="n2"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n3"/></subject></rdf:Description><rdf:Description rdf:about="rdf:#3107eb69-84ad-4ad3-aead-e7325d54ac65"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#243b0e77-7c3a-4a09-8370-4a35e254c30c"/></N></rdf:Description><rdf:Description rdf:about="rdf:#fc29216f-f933-4395-86ad-af87caeea93e"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2007-09-11T00:00:00+00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="#iyer_2004"><cmeta:comment><rdf:Description rdf:about="rdf:#73fb1875-f318-4cd4-86fc-222de5abca92"/></cmeta:comment><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n2"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#192d07ed-67a8-4279-8c15-f81eb1d183ee"/></reference><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:about="rdf:#$vhGBC2"/></simulation></rdf:Description><rdf:Description rdf:about="rdf:#$whGBC2"><rdf:first><rdf:Description rdf:about="rdf:#$xhGBC2"/></rdf:first><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest></rdf:Description><rdf:Description rdf:about="rdf:#73fb1875-f318-4cd4-86fc-222de5abca92"><rdf:value xml:lang="en">This file is a CellML description of Iyer et al's model of the human left ventricular epicardial myocyte as described in the paper "A Computational model of the human left-ventricular epicardial myocyte"</rdf:value><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#c63b0f0f-35d2-45d4-98a7-969320ffee8f"/></creator></rdf:Description><rdf:Description rdf:about="rdf:#87301142-03b1-46cc-93e5-9146a7272163"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#1281d5b9-4562-4c97-b2e9-9c30fcd6f310"/></N></rdf:Description><rdf:Description rdf:about="rdf:#240869d5-d2e7-4918-b218-a10f5f2a49c0"><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Oxford University</Orgname><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Dept of Physiology, Anatomy & Genetics</Orgunit></rdf:Description><rdf:Description rdf:about="rdf:#0746c562-31fc-4b36-87d5-fa1c50fa84c3"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type><rdf:_2><rdf:Description rdf:about="rdf:#6a9b6c17-ec4c-4c47-91c1-a8fa632be6db"/></rdf:_2><rdf:_1><rdf:Description rdf:about="rdf:#87301142-03b1-46cc-93e5-9146a7272163"/></rdf:_1><rdf:_3><rdf:Description rdf:about="rdf:#3107eb69-84ad-4ad3-aead-e7325d54ac65"/></rdf:_3></rdf:Description><rdf:Description rdf:about="rdf:#$vhGBC2"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:about="rdf:#$whGBC2"/></boundIntervals></rdf:Description><rdf:Description rdf:about="rdf:#53666f83-74be-4367-9ba3-e61ab647f708"><rdf:value xml:lang="en">This model is known to run in PCEnv 0.2 and COR and reproduces the published results. 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