- Author:
- jonna <devnull@localhost>
- Date:
- 2009-07-16 14:43:03+12:00
- Desc:
- Added General Files. Changed links of dependencies so can open from web-browser. Added RDF metadata for citation and keywords, removed publication link from documentation.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/guyton_thirst_drinking_and_salt_appetite_2008/rawfile/3550d5b0d53018baa71370966e310b4a672e1ae8/thirst.cellml
<?xml version="1.0" encoding="utf-8"?>
<model
name="thirst_drinking_and_salt_appetite_model"
cmeta:id="thirst_drinking_and_salt_appetite_model"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#thirst_drinking_and_salt_appetite_model">
<rdf:value>
The salt appetite is considered in this model to be related to the adequacy
of body metabolism, as measured by the PO2 level in the non-muscle tissue
cells (POT). Also, when the concentration of angiotensin increases (ANM),
this, too, increases salt intake. For instance, in circulatory shock, when
the adequacy of metabolism falls, the person develops a salt appetite. For
lack of information, no control function of salt concentration per se has
been assumed, merely that when the body salt falls, circulatory effectiveness
falls, angiotensin increases, and a salt appetite develops.
Three separate factors are assumed to drive the thirst mechanism, the
concentration of antidiuretic hormone, which in turn is driven by changes
in electrolyte composition (as detailed in another section) and second, the
effect of angiotensin on thirst, and third, the effect of the salt appetite
stimulation on thirst.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- ============================================= Import the required units from the Units file ==================================================== -->
<import xlink:href="units.cellml">
<units name="minute" units_ref="minute"/>
<units name="per_minute" units_ref="per_minute"/>
<units name="beats_per_minute" units_ref="beats_per_minute"/>
<units name="beats_per_minute_per_mmHg" units_ref="beats_per_minute_per_mmHg"/>
<units name="minute_per_L" units_ref="minute_per_L"/>
<units name="mmHg" units_ref="mmHg"/>
<units name="per_mmHg" units_ref="per_mmHg"/>
<units name="mmHg_per_mL" units_ref="mmHg_per_mL"/>
<units name="mmHg_L" units_ref="mmHg_L"/>
<units name="per_mmHg2" units_ref="per_mmHg2"/>
<units name="mmHg3" units_ref="mmHg3"/>
<units name="monovalent_mEq" units_ref="monovalent_mEq"/>
<units name="monovalent_mEq_per_minute" units_ref="monovalent_mEq_per_minute"/>
<units name="monovalent_mEq_per_litre" units_ref="monovalent_mEq_per_litre"/>
<units name="mOsm" units_ref="mOsm"/>
<units name="mOsm_per_litre" units_ref="mOsm_per_litre"/>
<units name="mOsm_per_minute" units_ref="mOsm_per_minute"/>
<units name="monovalent_mEq_per_litre_per_minute" units_ref="monovalent_mEq_per_litre_per_minute"/>
<units name="litre2_per_monovalent_mEq_per_minute" units_ref="litre2_per_monovalent_mEq_per_minute"/>
<units name="L_per_minute" units_ref="L_per_minute"/>
<units name="per_mmHg_per_minute" units_ref="per_mmHg_per_minute"/>
<units name="mL" units_ref="mL"/>
<units name="gram_per_L" units_ref="gram_per_L"/>
<units name="L_mmHg_per_gram" units_ref="L_mmHg_per_gram"/>
<units name="L2_mmHg_per_gram2" units_ref="L2_mmHg_per_gram2"/>
<units name="mmHg_minute_per_L" units_ref="mmHg_minute_per_L"/>
<units name="mmHg_L_per_minute" units_ref="mmHg_L_per_minute"/>
<units name="gram_per_minute" units_ref="gram_per_minute"/>
<units name="mL_per_L" units_ref="mL_per_L"/>
<units name="mL_per_L_per_mmHg" units_ref="mL_per_L_per_mmHg"/>
<units name="mL_per_L_per_minute" units_ref="mL_per_L_per_minute"/>
<units name="mL_per_minute_per_mmHg" units_ref="mL_per_minute_per_mmHg"/>
<units name="L_mL_per_minute_per_mmHg" units_ref="L_mL_per_minute_per_mmHg"/>
<units name="L_per_mL" units_ref="L_per_mL"/>
<units name="L_per_mmHg" units_ref="L_per_mmHg"/>
<units name="mL_per_minute" units_ref="mL_per_minute"/>
<units name="L_per_minute_per_mmHg" units_ref="L_per_minute_per_mmHg"/>
<units name="L_per_minute_per_mmHg2" units_ref="L_per_minute_per_mmHg2"/>
</import>
<!-- ===================================== Import all Parameters and State Variables from the Parameter file ============================================== -->
<import xlink:href="parameters.cellml">
<component component_ref="parameter_values" name="parameter_values"/>
<component component_ref="state_variables" name="state_variables"/>
</import>
<!-- ======================================== THIRST DRINKING AND SALT APPETITE TOP-LEVEL COMPONENT ============================================= -->
<component name="thirst_drinking_and_salt_appetite"
cmeta:id="thirst_drinking_and_salt_appetite">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#thirst_drinking_and_salt_appetite">
<rdf:value>
Encapsulation grouping component containing all the components in the Thirst, Drinking and Salt Appetite Model.
The inputs and outputs of the Thirst, Drinking and Salt Appetite Model must be passed by this component.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<variable name="time" units="minute" private_interface="out" public_interface="in"/>
<!-- Inputs from components in other models -->
<variable name="ADHC" units="dimensionless" private_interface="out" public_interface="in"/>
<variable name="ANM" units="dimensionless" private_interface="out" public_interface="in"/>
<variable name="POT" units="mmHg" private_interface="out" public_interface="in"/>
<!-- Outputs to components in other models -->
<variable name="TVD" units="L_per_minute" private_interface="in" public_interface="out"/>
<variable name="STH" units="dimensionless" private_interface="in" public_interface="out"/>
</component>
<!-- OUTPUT CONNECTIONS -->
<!-- <connection>
<map_components component_1="thirst_drinking_and_salt_appetite" component_2="rate_of_fluid_intake"/>
<map_variables variable_1="TVD" variable_2="TVD"/>
</connection> -->
<!-- <connection>
<map_components component_1="thirst_drinking_and_salt_appetite" component_2="effect_of_salt_appetite_stimulation_on_thirst"/>
<map_variables variable_1="STH" variable_2="STH"/>
</connection> -->
<!-- ======================================== EFFECT OF SALT APPETITE STIMULATION ON THIRST ============================================= -->
<component name="effect_of_salt_appetite_stimulation_on_thirst"
cmeta:id="effect_of_salt_appetite_stimulation_on_thirst">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#effect_of_salt_appetite_stimulation_on_thirst">
<rdf:value>
TS1, TS1A, TS2, TS2A, TS2B, TS2C, TS3, and TS4:
These are curve-fitting blocks to derive a value for salt appetite and for partial control of
thirst (STH) based on the input values of PO2 in the non-muscle tissue cells (POT) and the
angiotensin multiplier effect (ANM). The constant ANMSLT sets the sensitivity of salt appetite
to angiotensin, and the constant Z10 sets the PO2 level below which POT exerts its effects.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS2_TS2A_and_TS2B">
<rdf:value>
TS1, TS1A, TS2, TS2A, TS2B, TS2C, TS3, and TS4:
These are curve-fitting blocks to derive a value for salt appetite and for partial control of
thirst (STH) based on the input values of PO2 in the non-muscle tissue cells (POT) and the
angiotensin multiplier effect (ANM). The constant ANMSLT sets the sensitivity of salt appetite
to angiotensin, and the constant Z10 sets the PO2 level below which POT exerts its effects.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS1_TS1A_and_TS2C">
<rdf:value>
TS1, TS1A, TS2, TS2A, TS2B, TS2C, TS3, and TS4:
These are curve-fitting blocks to derive a value for salt appetite and for partial control of
thirst (STH) based on the input values of PO2 in the non-muscle tissue cells (POT) and the
angiotensin multiplier effect (ANM). The constant ANMSLT sets the sensitivity of salt appetite
to angiotensin, and the constant Z10 sets the PO2 level below which POT exerts its effects.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS3_and_TS4">
<rdf:value>
TS1, TS1A, TS2, TS2A, TS2B, TS2C, TS3, and TS4:
These are curve-fitting blocks to derive a value for salt appetite and for partial control of
thirst (STH) based on the input values of PO2 in the non-muscle tissue cells (POT) and the
angiotensin multiplier effect (ANM). The constant ANMSLT sets the sensitivity of salt appetite
to angiotensin, and the constant Z10 sets the PO2 level below which POT exerts its effects.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="ANM" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="POT" units="mmHg" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable cmeta:id="effect_of_salt_appetite_stimulation_on_thirst_STH"
name="STH" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ANMSLT" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="Z10" units="mmHg" private_interface="none" public_interface="in"/>
<variable name="Z11" units="per_mmHg2" private_interface="none" public_interface="in"/>
<!-- Internal variables -->
<variable name="ANMSML" units="dimensionless" private_interface="none" public_interface="none"/>
<variable name="STH1" units="dimensionless" private_interface="none" public_interface="none"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="TS2_TS2A_and_TS2B">
<eq/>
<ci>ANMSML</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>ANM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>ANMSLT</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply id="TS1_TS1A_and_TS2C">
<eq/>
<ci>STH1</ci>
<apply>
<times/>
<apply>
<power/>
<apply>
<minus/>
<ci>Z10</ci>
<ci>POT</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Z11</ci>
<ci>ANMSML</ci>
</apply>
</apply>
<apply id="TS3_and_TS4">
<eq/>
<ci>STH</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0.8</cn>
<apply>
<lt/>
<ci>STH1</ci>
<cn cellml:units="dimensionless">0.8</cn>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">8</cn>
<apply>
<gt/>
<ci>STH1</ci>
<cn cellml:units="dimensionless">8</cn>
</apply>
</piece>
<otherwise>
<ci>STH1</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="effect_of_salt_appetite_stimulation_on_thirst" component_2="thirst_drinking_and_salt_appetite"/>
<map_variables variable_1="STH" variable_2="STH"/>
<map_variables variable_1="ANM" variable_2="ANM"/>
<map_variables variable_1="POT" variable_2="POT"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="effect_of_salt_appetite_stimulation_on_thirst" component_2="parameter_values"/>
<map_variables variable_1="ANMSLT" variable_2="ANMSLT"/>
<map_variables variable_1="Z10" variable_2="Z10"/>
<map_variables variable_1="Z11" variable_2="Z11"/>
</connection>
<!-- ============================================== EFFECT OF ANTIDIURETIC HOMONE ON THIRST =============================================== -->
<component name="effect_of_antidiuretic_hormone_on_thirst"
cmeta:id="effect_of_antidiuretic_hormone_on_thirst">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#effect_of_antidiuretic_hormone_on_thirst">
<rdf:value>
TS5, TS6, and TS7:
These blocks are a sensitivity controller for calculating a multiplier effect
of antidiuretic hormone on thirst (AHCM) from an antidiuretic hormone
concentration factor in the circulating body fluids (ADHC). The sensitivity is
controlled by the control factor (AHTHM).
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS5_to_TS7">
<rdf:value>
TS5, TS6, and TS7:
These blocks are a sensitivity controller for calculating a multiplier effect
of antidiuretic hormone on thirst (AHCM) from an antidiuretic hormone
concentration factor in the circulating body fluids (ADHC). The sensitivity is
controlled by the control factor (AHTHM).
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="ADHC" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable name="AHCM" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="AHTHM" units="dimensionless" private_interface="none" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="TS5_to_TS7">
<eq/>
<ci>AHCM</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>ADHC</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>AHTHM</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="effect_of_antidiuretic_hormone_on_thirst" component_2="thirst_drinking_and_salt_appetite"/>
<map_variables variable_1="ADHC" variable_2="ADHC"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="effect_of_antidiuretic_hormone_on_thirst" component_2="parameter_values"/>
<map_variables variable_1="AHTHM" variable_2="AHTHM"/>
</connection>
<!-- ========================================= EFFECT OF ANGIOTENSIN ON THIRST ============================================================== -->
<component name="effect_of_angiotensin_on_thirst"
cmeta:id="effect_of_angiotensin_on_thirst">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#effect_of_angiotensin_on_thirst">
<rdf:value>
TS10 and TS11:
Calculation of the drive to stimulate thirst caused by angiotensin (ANMH) from
the generalized angiotensin multiplier (ANM). The sensitivity of this calculation
is controlled by the angiotensin-thirst sensitivity control variable (ANMTM).
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS10_and_TS11">
<rdf:value>
TS10 and TS11:
Calculation of the drive to stimulate thirst caused by angiotensin (ANMH) from
the generalized angiotensin multiplier (ANM). The sensitivity of this calculation
is controlled by the angiotensin-thirst sensitivity control variable (ANMTM).
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="ANM" units="dimensionless" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable name="ANMTH" units="dimensionless" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="ANMTM" units="dimensionless" private_interface="none" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="TS10_and_TS11">
<eq/>
<ci>ANMTH</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>ANM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>ANMTM</ci>
<cn cellml:units="dimensionless">0.001</cn>
</apply>
</apply>
</math>
</component>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="effect_of_angiotensin_on_thirst" component_2="thirst_drinking_and_salt_appetite"/>
<map_variables variable_1="ANM" variable_2="ANM"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="effect_of_angiotensin_on_thirst" component_2="parameter_values"/>
<map_variables variable_1="ANMTM" variable_2="ANMTM"/>
</connection>
<!-- ================================================ RATE OF FLUID INTAKE =============================================================== -->
<component name="rate_of_fluid_intake"
cmeta:id="rate_of_fluid_intake">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="#rate_of_fluid_intake">
<rdf:value>
TS8 and TS9:
Calculation of a thirst drive (AHTH) based on antidiuretic hormone and salt
appetite by multiplying three factors, the salt appetite drive (STH), the antidiuretic
hormone concentration multiplier (AHCM), and a constant. Block TS9 sets a lower limit
to AHTH equal to zero.
TS12 and TS13:
A temporary calculation for rate of intake of fluid by the body (TVZ) is equal to the
drinking drive (AHTH) caused by the product of the salt appetite drive (STH) and the
antidiuretic-thirst drive (AHTH), plus the angiotensin-thirst drive (ANMTH). Block
TS13 sets the lower limit of (TVZ) to zero.
TS14, TS15, and TS16:
This is a delay circuit which causes the actual rate of fluid intake (TVD) to be delayed
with respect to changes in the temporarily calculated rate of fluid intake (TVZ) by a
time constant TVDLL. Also shown in Block TS14 is a variable (DR) that can be used for
forced input of water over and above the natural drinking desires; this can be used for
intravenous infusion of water as well.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS8">
<rdf:value>
TS8:
Calculation of a thirst drive (AHTH) based on antidiuretic hormone and salt
appetite by multiplying three factors, the salt appetite drive (STH), the antidiuretic
hormone concentration multiplier (AHCM), and a constant.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS9">
<rdf:value>
TS9:
Block TS9 sets a lower limit to AHTH equal to zero.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS12">
<rdf:value>
TS12:
A temporary calculation for rate of intake of fluid by the body (TVZ) is equal to the
drinking drive (AHTH) caused by the product of the salt appetite drive (STH) and the
antidiuretic-thirst drive (AHTH), plus the angiotensin-thirst drive (ANMTH).
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS13">
<rdf:value>
TS13:
Block TS13 sets the lower limit of (TVZ) to zero.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="#TS14_to_TS16">
<rdf:value>
TS14, TS15, and TS16:
This is a delay circuit which causes the actual rate of fluid intake (TVD) to be delayed
with respect to changes in the temporarily calculated rate of fluid intake (TVZ) by a
time constant TVDLL. Also shown in Block TS14 is a variable (DR) that can be used for
forced input of water over and above the natural drinking desires; this can be used for
intravenous infusion of water as well.
</rdf:value>
</rdf:Description>
</rdf:RDF>
<!-- Inputs from other components -->
<variable name="STH" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="AHCM" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="ANMTH" units="dimensionless" private_interface="none" public_interface="in"/>
<variable name="TVD_init" units="L_per_minute" private_interface="none" public_interface="in"/>
<variable name="time" units="minute" private_interface="none" public_interface="in"/>
<!-- Outputs to other components -->
<variable cmeta:id="rate_of_fluid_intake_TVD"
name="TVD" initial_value="TVD_init" units="L_per_minute" private_interface="none" public_interface="out"/>
<!-- Parameters from parameter_file -->
<variable name="DR" units="L_per_minute" private_interface="none" public_interface="in"/>
<variable name="TVDDL" units="minute" private_interface="none" public_interface="in"/>
<!-- Internal variables -->
<variable name="AHTH" units="dimensionless" private_interface="none" public_interface="none"/>
<variable name="AHTH1" units="dimensionless" private_interface="none" public_interface="none"/>
<variable name="TVZ" units="L_per_minute" private_interface="none" public_interface="none"/>
<variable name="TVZ1" units="L_per_minute" private_interface="none" public_interface="none"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="TS8">
<eq/>
<ci>AHTH1</ci>
<apply>
<times/>
<ci>AHCM</ci>
<ci>STH</ci>
<cn cellml:units="dimensionless">0.001</cn>
</apply>
</apply>
<apply id="TS9">
<eq/>
<ci>AHTH</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0</cn>
<apply>
<lt/>
<ci>AHTH1</ci>
<cn cellml:units="dimensionless">0</cn>
</apply>
</piece>
<otherwise>
<ci>AHTH1</ci>
</otherwise>
</piecewise>
</apply>
<apply id="TS12">
<eq/>
<ci>TVZ1</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>ANMTH</ci>
<ci>AHTH</ci>
</apply>
<cn cellml:units="L_per_minute">1</cn>
</apply>
</apply>
<apply id="TS13">
<eq/>
<ci>TVZ</ci>
<piecewise>
<piece>
<cn cellml:units="L_per_minute">0</cn>
<apply>
<lt/>
<ci>TVZ1</ci>
<cn cellml:units="L_per_minute">0</cn>
</apply>
</piece>
<otherwise>
<ci>TVZ1</ci>
</otherwise>
</piecewise>
</apply>
<apply id="TS14_to_TS16">
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>TVD</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>TVZ</ci>
<ci>DR</ci>
</apply>
<ci>TVD</ci>
</apply>
<ci>TVDDL</ci>
</apply>
</apply>
</math>
</component>
<!-- STATE VARIABLES INITIAL CONDITION -->
<connection>
<map_components component_1="rate_of_fluid_intake" component_2="state_variables"/>
<map_variables variable_1="TVD_init" variable_2="TVD_init"/>
</connection>
<!-- INPUT CONNECTIONS -->
<connection>
<map_components component_1="rate_of_fluid_intake" component_2="effect_of_antidiuretic_hormone_on_thirst"/>
<map_variables variable_1="AHCM" variable_2="AHCM"/>
</connection>
<connection>
<map_components component_1="rate_of_fluid_intake" component_2="effect_of_salt_appetite_stimulation_on_thirst"/>
<map_variables variable_1="STH" variable_2="STH"/>
</connection>
<connection>
<map_components component_1="rate_of_fluid_intake" component_2="effect_of_angiotensin_on_thirst"/>
<map_variables variable_1="ANMTH" variable_2="ANMTH"/>
</connection>
<connection>
<map_components component_1="rate_of_fluid_intake" component_2="thirst_drinking_and_salt_appetite"/>
<map_variables variable_1="TVD" variable_2="TVD"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<!-- PARAMETER CONNECTIONS -->
<connection>
<map_components component_1="rate_of_fluid_intake" component_2="parameter_values"/>
<map_variables variable_1="DR" variable_2="DR"/>
<map_variables variable_1="TVDDL" variable_2="TVDDL"/>
</connection>
<!-- ============================================================ GROUPING =============================================================== -->
<group>
<relationship_ref relationship="containment"/>
<component_ref component="thirst_drinking_and_salt_appetite">
<component_ref component="effect_of_salt_appetite_stimulation_on_thirst"/>
<component_ref component="effect_of_antidiuretic_hormone_on_thirst"/>
<component_ref component="effect_of_angiotensin_on_thirst"/>
<component_ref component="rate_of_fluid_intake"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="thirst_drinking_and_salt_appetite">
<component_ref component="parameter_values"/>
<component_ref component="state_variables"/>
<component_ref component="effect_of_salt_appetite_stimulation_on_thirst"/>
<component_ref component="effect_of_antidiuretic_hormone_on_thirst"/>
<component_ref component="effect_of_angiotensin_on_thirst"/>
<component_ref component="rate_of_fluid_intake"/>
</component_ref>
</group>
</model>
