This is the CellML 1.1 "parent" file to test the Aldosterone Model.
Guyton Model: Aldosterone
Catherine
Lloyd
Auckland Bioengineering Institute, University of Auckland
CellML 1.1 Version
This is a CellML 1.1 version of the Aldosterone Module of the Guyton Circulation model. To run, click on "Solve using OpenCell" and all
dependent files and components will be imported. To run offline, please download all files from the workspace into the same directory and open
"aldosterone_parent.cellml" in OpenCell.
Model Status
This CellML model has been validated. Due to the differences between procedural code (in this case C-code)
and declarative languages (CellML), some aspects of the original model were not able to be encapsulated by
the CellML model (such as the damping of variables). This may effect the transient behaviour of the model,
however the steady-state behaviour would remain the same. The equations in this file and the steady-state
output from the model conform to the results from the MODSIM program.
Model Structure
Arthur Guyton (1919-2003) was an American physiologist who became famous for his 1950s experiments in which he studied
the physiology of cardiac output and its relationship with the peripheral circulation. The results of these experiments
challenged the conventional wisdom that it was the heart itself that controlled cardiac output. Instead Guyton
demonstrated that it was the need of the body tissues for oxygen which was the real regulator of cardiac output.
The "Guyton Curves" describe the relationship between right atrial pressures and cardiac output, and they form a
foundation for understanding the physiology of circulation.
The Guyton model of fluid, electrolyte, and circulatory regulation is an extensive mathematical model of human circulatory
physiology, capable of simulating a variety of experimental conditions, and contains a number of linked subsystems relating
to circulation and its neuroendocrine control.
This is a CellML translation of the Guyton model of the regulation of the circulatory system. The complete model consists
of separate modules each of which characterise a separate physiological subsystems. The Circulation Dynamics is the primary
system, to which other modules/blocks are connected. The other modules characterise the dynamics of the kidney,
electrolytes and cell water, thirst and drinking, hormone regulation, autonomic regulation, cardiovascular system etc,
and these feedback on the central circulation model. The CellML code in these modules is based on the C code from the
programme C-MODSIM created by Dr Jean-Pierre Montani.
This particular CellML model describes how aldosterone and its feedback control functions to modify the circulation.
Two inputs are used for controlling aldosterone secretion, the potassium concentration in the extracellular fluids (CKE)
and the effect of angiotensin (ANM) on aldosterone secretion. In turn, multiplier effects for aldosterone control of
potassium (AMK) and sodium (AMNA) transport through cell membranes, especially through the kidney tubule membranes are calculated.
model diagram
A systems analysis diagram for the full Guyton model describing circulation regulation.
model diagram
A schematic diagram of the components and processes described in the current CellML model.
There are several publications referring to the Guyton model. One of these papers is cited below:
Circulation: Overall Regulation, A.C. Guyton, T.G. Coleman, and H.J. Granger, 1972,
Annual Review of Physiology
, 34, 13-44. PubMed ID: 4334846
Description of Guyton aldosterone module (CellML 1.1)
Terkildsen
Jonna
j.terkildsen@auckland.ac.nz
The University of Auckland
The Bioengineering Institute
2008-04-03
The University of Auckland, Bioengineering Institute
Guyton
Aldosterone
Description of Guyton aldosterone module
2008-00-00 00:00
keyword
physiology
organ systems
cardiovascular circulation
aldosterone
Guyton
Component to set all input values to 1.0 or a prescribed value.