- Author:
- Dougal Cowan <devnull@localhost>
- Date:
- 2013-02-05 12:27:11+13:00
- Desc:
- Replaced the annotated model file with a new version containing identifiers.org URIs instead of MIRIAM URNs.
This version was created by Alan Garny after discussion with Camille Laibe.
These annotated models were used in development of OpenCOR's annotation features.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/goldbeter_1991/rawfile/d4499286b0a177a10456a48c41e3fe34e63e827d/goldbeter_1991_1.1.cellml
<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" name="goldbeter_1991_1.1"><import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="goldbeter_1991_units.cellml"><units name="minute" units_ref="minute"/><units name="first_order_rate_constant" units_ref="first_order_rate_constant"/><units name="flux" units_ref="flux"/><units name="micromolar" units_ref="micromolar"/></import><component name="environment"><variable name="time" public_interface="out" units="minute"/></component><component name="C"><math xmlns="http://www.w3.org/1998/Math/MathML" id="C_maths"><apply id="C_equation"><eq/><apply><diff/><bvar><ci>time</ci></bvar><ci>C</ci></apply><apply><minus/><apply><minus/><ci>vi</ci><apply><divide/><apply><times/><ci>vd</ci><ci>X</ci><ci>C</ci></apply><apply><plus/><ci>Kd</ci><ci>C</ci></apply></apply></apply><apply><times/><ci>kd</ci><ci>C</ci></apply></apply></apply></math><variable initial_value="0.01" name="C" public_interface="out" units="micromolar"/><variable name="X" public_interface="in" units="dimensionless"/><variable name="kd" public_interface="in" units="first_order_rate_constant"/><variable name="Kd" public_interface="in" units="micromolar"/><variable name="vi" public_interface="in" units="flux"/><variable name="vd" public_interface="in" units="flux"/><variable name="time" public_interface="in" units="minute"/></component><component name="M"><variable name="M" private_interface="in" public_interface="out" units="dimensionless"/><variable name="M_star" private_interface="out" public_interface="in" units="dimensionless"/><variable name="V1" private_interface="out" public_interface="in" units="first_order_rate_constant"/><variable name="V2" private_interface="out" public_interface="in" units="first_order_rate_constant"/><variable name="K1" private_interface="out" public_interface="in" units="dimensionless"/><variable name="K2" private_interface="out" public_interface="in" units="dimensionless"/><variable name="time" private_interface="out" public_interface="in" units="minute"/><variable initial_value="0.01" name="M_init" private_interface="out" units="dimensionless"/></component><group><relationship_ref relationship="encapsulation"/><component_ref component="M"><component_ref component="law1_M"/></component_ref></group><import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="goldbeter_1991_constitutive_law1.cellml"><component component_ref="constitutive_law1" name="law1_M"/></import><connection><map_components component_1="M" component_2="law1_M"/><map_variables variable_1="M" variable_2="A"/><map_variables variable_1="V1" variable_2="B"/><map_variables variable_1="M_star" variable_2="C"/><map_variables variable_1="K1" variable_2="D"/><map_variables variable_1="V2" variable_2="E"/><map_variables variable_1="K2" variable_2="F"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="M_init" variable_2="A_init"/></connection><component name="M_star"><variable name="M_star" private_interface="in" public_interface="out" units="dimensionless"/><variable name="M" private_interface="out" public_interface="in" units="dimensionless"/></component><import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="goldbeter_1991_constitutive_law2.cellml"><component component_ref="constitutive_law2" name="law2_M"/></import><group><relationship_ref relationship="encapsulation"/><component_ref component="M_star"><component_ref component="law2_M"/></component_ref></group><connection><map_components component_1="law2_M" component_2="M_star"/><map_variables variable_1="A" variable_2="M_star"/><map_variables variable_1="B" variable_2="M"/></connection><component name="X"><variable name="X" private_interface="in" public_interface="out" units="dimensionless"/><variable initial_value="0.01" name="X_init" private_interface="out" units="dimensionless"/><variable name="X_star" private_interface="out" public_interface="in" units="dimensionless"/><variable name="V3" private_interface="out" public_interface="in" units="first_order_rate_constant"/><variable name="V4" private_interface="out" public_interface="in" units="first_order_rate_constant"/><variable name="K3" private_interface="out" public_interface="in" units="dimensionless"/><variable name="K4" private_interface="out" public_interface="in" units="dimensionless"/><variable name="time" private_interface="out" public_interface="in" units="minute"/></component><import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="goldbeter_1991_constitutive_law1.cellml"><component component_ref="constitutive_law1" name="law1_X"/></import><group><relationship_ref relationship="encapsulation"/><component_ref component="X"><component_ref component="law1_X"/></component_ref></group><connection><map_components component_1="law1_X" component_2="X"/><map_variables variable_1="A" variable_2="X"/><map_variables variable_1="A_init" variable_2="X_init"/><map_variables variable_1="B" variable_2="V3"/><map_variables variable_1="C" variable_2="X_star"/><map_variables variable_1="D" variable_2="K3"/><map_variables variable_1="E" variable_2="V4"/><map_variables variable_1="F" variable_2="K4"/><map_variables variable_1="time" variable_2="time"/></connection><component name="X_star"><variable name="X_star" private_interface="in" public_interface="out" units="dimensionless"/><variable name="X" private_interface="out" public_interface="in" units="dimensionless"/></component><import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="goldbeter_1991_constitutive_law2.cellml"><component component_ref="constitutive_law2" name="law2_Xstar"/></import><group><relationship_ref relationship="encapsulation"/><component_ref component="X_star"><component_ref component="law2_Xstar"/></component_ref></group><connection><map_components component_1="law2_Xstar" component_2="X_star"/><map_variables variable_1="A" variable_2="X_star"/><map_variables variable_1="B" variable_2="X"/></connection><component name="parameters"><variable initial_value="0.025" name="vi" public_interface="out" units="flux"/><variable initial_value="0.25" name="vd" public_interface="out" units="flux"/><variable initial_value="0.01" name="kd" public_interface="out" units="first_order_rate_constant"/><variable initial_value="0.02" name="Kd" public_interface="out" units="micromolar"/><variable initial_value="0.5" name="Kc" public_interface="out" units="micromolar"/><variable initial_value="0.005" name="K1" public_interface="out" units="dimensionless"/><variable initial_value="0.005" name="K2" public_interface="out" units="dimensionless"/><variable initial_value="0.005" name="K3" public_interface="out" units="dimensionless"/><variable initial_value="0.005" name="K4" public_interface="out" units="dimensionless"/><variable name="V1" public_interface="out" units="first_order_rate_constant"/><variable initial_value="1.5" name="V2" public_interface="out" units="first_order_rate_constant"/><variable name="V3" public_interface="out" units="first_order_rate_constant"/><variable initial_value="0.5" name="V4" public_interface="out" units="first_order_rate_constant"/><variable initial_value="3" name="VM1" public_interface="out" units="first_order_rate_constant"/><variable initial_value="1" name="VM3" public_interface="out" units="first_order_rate_constant"/><variable name="C" public_interface="in" units="micromolar"/><variable name="M" public_interface="in" units="dimensionless"/><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><ci>V1</ci><apply><divide/><apply><times/><ci>VM1</ci><ci>C</ci></apply><apply><plus/><ci>Kc</ci><ci>C</ci></apply></apply></apply><apply><eq/><ci>V3</ci><apply><times/><ci>M</ci><ci>VM3</ci></apply></apply></math></component><connection><map_components component_1="environment" component_2="C"/><map_variables variable_1="time" variable_2="time"/></connection><connection><map_components component_1="environment" component_2="M"/><map_variables variable_1="time" variable_2="time"/></connection><connection><map_components component_1="environment" component_2="X"/><map_variables variable_1="time" variable_2="time"/></connection><connection><map_components component_1="M_star" component_2="M"/><map_variables variable_1="M" variable_2="M"/><map_variables variable_1="M_star" variable_2="M_star"/></connection><connection><map_components component_1="X_star" component_2="X"/><map_variables variable_1="X_star" variable_2="X_star"/><map_variables variable_1="X" variable_2="X"/></connection><connection><map_components component_1="C" component_2="parameters"/><map_variables variable_1="kd" variable_2="kd"/><map_variables variable_1="Kd" variable_2="Kd"/><map_variables variable_1="vi" variable_2="vi"/><map_variables variable_1="vd" variable_2="vd"/><map_variables variable_1="C" variable_2="C"/></connection><connection><map_components component_1="C" component_2="X"/><map_variables variable_1="X" variable_2="X"/></connection><connection><map_components component_1="M" component_2="parameters"/><map_variables variable_1="V1" variable_2="V1"/><map_variables variable_1="V2" variable_2="V2"/><map_variables variable_1="K1" variable_2="K1"/><map_variables variable_1="K2" variable_2="K2"/><map_variables variable_1="M" variable_2="M"/></connection><connection><map_components component_1="X" component_2="parameters"/><map_variables variable_1="V3" variable_2="V3"/><map_variables variable_1="V4" variable_2="V4"/><map_variables variable_1="K3" variable_2="K3"/><map_variables variable_1="K4" variable_2="K4"/></connection></model>
