- Author:
- rcai987 <devnull@localhost>
- Date:
- 2015-02-02 13:03:56+13:00
- Desc:
- Added annotations to fridyland_tamarina_philipson_2003.cellml model
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/fridlyand_tamarina_philipson_2003/rawfile/c0bc0382dc05eca7b252df50d363445468825c26/fridlyand_tamarina_philipson_2003.cellml
<?xml version="1.0"?>
<!-- FILE : fridlyand_model_2003.xml
CREATED : 14th November 2002
LAST MODIFIED : 14th November 2003
AUTHOR : Catherine Lloyd
The Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the CellML Metadata 1.0 Specification released on 16th
January, 2002.
DESCRIPTION : This file contains a CellML description of Fridlyand et al's 2003 mathematical model of Ca2+ fluxes in pancreatic beta-cells.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xml:base="file:///H:/fridlyand_tamarina_philipson_2003/fridlyand_tamarina_philipson_2003.cellml" cmeta:id="fridlyand_tamarina_philipson_2003_version01" name="fridlyand_tamarina_philipson_2003_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling Ca2+ Flux in Pancreatic Beta-cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
An increase in the concentration of intracellular free calcium ([Ca<superscript>2+</superscript>]<subscript>i</subscript>) is an essential signal for the initiation of insulin secretion in pancreatic beta-cells. This increase is primarily due to the opening of Ca<superscript>2+</superscript> channels in the plasma membrane in response to glucose. Glucose metabolism leads to an increase in the cytosolic ATP:ADP ratio, which in turn causes the ATP-sensitive potassium channels to close. The beta-cell membrane becomes depolarised, Ca<superscript>2+</superscript> channels open, and Ca<superscript>2+</superscript> enters the cell. These events underlie the glucose-induced electrical activity, which in pancreatic islets, consists of Ca<superscript>2+</superscript>-dependent action potentials.
</para>
<para>
There is an abundance of literature that describes beta-cell electrical activity and its relationship to [Ca<superscript>2+</superscript>]<subscript>i</subscript>. Complex and cyclic spike-burst activity, and corresponding [Ca<superscript>2+</superscript>]<subscript>i</subscript> oscillations in pancreatic islets and beta-cell clusters are induced in response to a rise in extracellular glucose concentration. Intermediate glucose concentrations induce both fast and slow oscillations. The authors of this current study: Fridlyand, Tamarina and Philipson, have previously studied slow and fast [Ca<superscript>2+</superscript>]<subscript>i</subscript> oscillations in islets in response to a variety of conditions. However, the experimental results were complex, and precise understanding was limited by the large number of channels and pumps in the beta-cell plasma membrane that were simultaneously working.
</para>
<para>
In order to better understand the molecular mechanisms underlying this behaviour, in this publication Fridlyand <emphasis>et al.</emphasis> have developed a mathematical model of the Ca<superscript>2+</superscript> fluxes in pancreatic beta-cells. Several other mathematical models of glucose-induced insulin secretion, with corresponding descriptions of glucose transport, metabolism and ion regulation, have been published. These include:
</para>
<itemizedlist>
<listitem>
<para>
<ulink url="${HTML_EXMPL_CHAY_MODEL97}">Extracellular and Intracellular Calcium Effects on Pancreatic Beta Cells, Chay, 1997</ulink>;</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_GALL_MODEL}">Na<superscript>+</superscript>/Ca<superscript>2+</superscript> Exchange in Models for Pancreatic Beta-Cells, Gall and Susa, 1999</ulink>; and</para>
</listitem>
<listitem>
<para>
<ulink url="${HTML_EXMPL_BERTRAM_MODEL}">The Phantom Burster Model for Pancreatic Beta-Cells, Bertram <emphasis>et al.</emphasis>, 2000</ulink>.</para>
</listitem>
</itemizedlist>
<para>
However, most of these models are focused on describing one specific phenomenon. They only include a very limited set of channels and pumps, and therefore it is difficult to apply them to a another situation. In addition, since their publication, new experimental data has become available, and these new findings should be included in a theoretical model. For this reason Fridlyand <emphasis>et al.</emphasis> have developed the new mathematical model described here (see the raw CellML description of the Fridlyand <emphasis>et al.</emphasis> 2003 model in <xref linkend="sec_download_this_model"/>). They have adopted the more complex style of modelling that has previously been used successfully to describe the electrophysiology of cardiac myocytes and other cell types (for example in <ulink url="${HTML_EXMPL_NYGREN_ATRIAL_MODEL}">Human Atrial Cell Model, Nygren <emphasis>et al.</emphasis> 1998</ulink> and in <ulink url="${HTML_EXMPL_RICE_MODEL2}">Modelling Interval-Force Relations in Cardiac Muscle, Rice <emphasis>et al.</emphasis>, 2000</ulink>). </para>
<para>
Their new model includes a wider range of channels and pumps, as well as endoplasmic reticulum (ER) Ca<superscript>2+</superscript> sequestration mechanisms (see <xref linkend="fig_cell_diagram"/> below). Using this model they were able to simulate whole cell electrical activity and [Ca<superscript>2+</superscript>]<subscript>i</subscript>, free calcium in the ER ([Ca<superscript>2+</superscript>]<subscript>ER</subscript>), intracellular Na<superscript> +</superscript> ([Na<superscript>+</superscript>]<subscript>i</subscript>), cytosolic ATP ([ATP]<subscript>i</subscript>), and inositol triphosphate ([IP<subscript>3</subscript>]<subscript>i</subscript>) concentrations. However, they acknowledge that this model does not consider metabolic processes or insulin secretion.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://ajpendo.physiology.org/cgi/content/abstract/285/1/E138">Modeling of Ca<superscript>2+</superscript> flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores</ulink>, Leonid E. Fridlyand, Natalia Tamarina, and Louis H. Philipson, 2003, <ulink url="http://ajpendo.physiology.org/">
<emphasis>American Journal of Physiology</emphasis>
</ulink>, 285, E138-E154. (<ulink url="http://ajpendo.physiology.org/cgi/content/full/285/1/E138">Full text (HTML)</ulink> and <ulink url="http://ajpendo.physiology.org/cgi/reprint/285/1/E138.pdf">PDF</ulink> versions of the article are available on the <emphasis>American Jounal of Physiology</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12644446&dopt=Abstract">PubMed ID: 12644446</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="fridlyand_2003.png"/>
</imageobject>
</mediaobject>
<caption>Schematic representation of currents and ion fluxes, through the plasma membrane and the endoplasmic reticulum membrane, which have been included in the whole beta-cell mathematical model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="millisecond">
<unit prefix="milli" units="second"/>
</units>
<units name="first_order_rate_constant">
<unit exponent="-1" units="millisecond"/>
</units>
<units name="second_order_rate_constant">
<unit exponent="-1" units="micromolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="third_order_rate_constant">
<unit exponent="-2" units="micromolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="forth_order_rate_constant">
<unit exponent="-3" units="micromolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="flux">
<unit units="micromolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="picoS_per_millivolt">
<unit units="picoS"/>
<unit exponent="-1" units="millivolt"/>
</units>
<units name="per_millivolt_millisecond">
<unit exponent="-1" units="millivolt"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="picoS">
<unit prefix="pico" units="siemens"/>
</units>
<units name="picol">
<unit prefix="pico" units="litre"/>
</units>
<units name="picol_per_ms">
<unit units="picol"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="femtoA">
<unit prefix="femto" units="ampere"/>
</units>
<units name="femtoF">
<unit prefix="femto" units="farad"/>
</units>
<units name="millimolar">
<unit prefix="micro" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="micromolar">
<unit prefix="micro" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="joule_per_kilomole_kelvin">
<unit units="joule"/>
<unit exponent="-1" prefix="kilo" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit exponent="-1" units="mole"/>
</units>
<component name="environment">
<variable name="time" public_interface="out" units="millisecond"/>
</component>
<component cmeta:id="id_00001" name="membrane">
<variable initial_value="-84.624" name="V" public_interface="out" units="millivolt"/>
<variable initial_value="6158.0" name="Cm" units="femtoF"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable cmeta:id="id_00001" name="i_VCa" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00022" name="i_Ca_pump" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00028" name="i_NaCa" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00002" name="i_CRAN" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00035" name="i_Na" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00045" name="i_NaK" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00051" name="i_KDr" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00068" name="i_KCa" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00076" name="i_KATP" public_interface="in" units="femtoA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="membrane_voltage_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> V </ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<ci> i_VCa </ci>
<ci> i_Ca_pump </ci>
<ci> i_NaCa </ci>
<ci> i_CRAN </ci>
<ci> i_Na </ci>
<ci> i_NaK </ci>
<ci> i_KDr </ci>
<ci> i_KCa </ci>
<ci> i_KATP </ci>
</apply>
<apply>
<minus/>
<ci> Cm </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00012" name="whole_cell_calcium_current">
<variable cmeta:id="id_00013" name="i_VCa" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00014" name="V_Ca" units="millivolt"/>
<variable cmeta:id="id_00015" initial_value="770.0" name="gm_VCa" units="picoS"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable name="Cao" public_interface="in" units="micromolar"/>
<variable cmeta:id="id_00016" name="p_VCa" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_VCa_calculation">
<eq/>
<ci> i_VCa </ci>
<apply>
<times/>
<ci> gm_VCa </ci>
<ci> p_VCa </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> V_Ca </ci>
</apply>
</apply>
</apply>
<apply id="V_Ca_calculation">
<eq/>
<ci> V_Ca </ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci> F </ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci> Cao </ci>
<ci> Cai </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00017" name="whole_cell_calcium_current_p_VCa_gate">
<variable cmeta:id="id_00018" name="p_VCa" public_interface="out" units="dimensionless"/>
<variable cmeta:id="id_00019" initial_value="-19.0" name="V_Cah" units="millivolt"/>
<variable cmeta:id="id_00020" initial_value="9.5" name="K_Cah" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="p_VCa_calculation">
<eq/>
<ci> p_VCa </ci>
<apply>
<divide/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci> V_Cah </ci>
<ci> V </ci>
</apply>
<ci> K_Cah </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00023" name="PM_calcium_pumps">
<variable cmeta:id="id_00024" name="i_Ca_pump" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00025" initial_value="2000.0" name="Pm_Cap" units="femtoA"/>
<variable cmeta:id="id_00026" initial_value="0.1" name="K_Cap" units="micromolar"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_Ca_pump_calculation">
<eq/>
<ci> i_Ca_pump </ci>
<apply>
<times/>
<ci> Pm_Cap </ci>
<apply>
<divide/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci> K_Cap </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00029" name="sodium_calcium_exchanger">
<variable cmeta:id="id_00030" name="i_NaCa" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00031" name="V_NaCa" units="millivolt"/>
<variable cmeta:id="id_00032" initial_value="271.0" name="g_NaCa" units="picoS"/>
<variable cmeta:id="id_00033" initial_value="0.75" name="K_NaCa" units="micromolar"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable name="Cao" public_interface="in" units="micromolar"/>
<variable name="Nai" public_interface="in" units="micromolar"/>
<variable name="Nao" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_NaCa_calculation">
<eq/>
<ci> i_NaCa </ci>
<apply>
<times/>
<ci> g_NaCa </ci>
<apply>
<divide/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 5.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 5.0 </cn>
</apply>
<apply>
<power/>
<ci> K_NaCa </ci>
<cn cellml:units="dimensionless"> 5.0 </cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci> V </ci>
<ci> V_NaCa </ci>
</apply>
</apply>
</apply>
<apply id="V_NaCa_calculation">
<eq/>
<ci> V_NaCa </ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
<ci> F </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 3.0 </cn>
<apply>
<ln/>
<apply>
<divide/>
<ci> Nao </ci>
<ci> Nai </ci>
</apply>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci> Cao </ci>
<ci> Cai </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00003" name="nonselective_cation_current">
<variable cmeta:id="id_00004" name="i_CRAN" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00005" initial_value="0.0" name="V_CRAN" units="millivolt"/>
<variable cmeta:id="id_00006" initial_value="0.7" name="gm_CRAN" units="picoS_per_millivolt"/>
<variable cmeta:id="id_00007" initial_value="200.0" name="K_Car" units="micromolar"/>
<variable cmeta:id="id_00008" name="f_CRAN" units="dimensionless"/>
<variable cmeta:id="id_00009" name="P_CRAN" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="V_Na" public_interface="in" units="millivolt"/>
<variable name="CaER" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_CRAN_calculation">
<eq/>
<ci> i_CRAN </ci>
<apply>
<times/>
<ci> f_CRAN </ci>
<ci> P_CRAN </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> V_Na </ci>
</apply>
</apply>
</apply>
<apply id="f_CRAN_calculation">
<eq/>
<ci> f_CRAN </ci>
<apply>
<divide/>
<apply>
<minus/>
<ci> gm_CRAN </ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci> CaER </ci>
<ci> K_Car </ci>
</apply>
<cn cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="P_CRAN_calculation">
<eq/>
<ci> P_CRAN </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> V_CRAN </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00036" name="sodium_current">
<variable cmeta:id="id_00037" name="i_Na" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00038" name="V_Na" public_interface="out" units="millivolt"/>
<variable cmeta:id="id_00039" initial_value="1200.0" name="gm_Na" units="picoS"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Nai" public_interface="in" units="micromolar"/>
<variable name="Nao" public_interface="in" units="micromolar"/>
<variable cmeta:id="id_00040" name="p_Na" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_Na_calculation">
<eq/>
<ci> i_Na </ci>
<apply>
<times/>
<ci> gm_Na </ci>
<ci> p_Na </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> V_Na </ci>
</apply>
</apply>
</apply>
<apply id="V_Na_calculation">
<eq/>
<ci> V_Na </ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
<ci> F </ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci> Nao </ci>
<ci> Nai </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00041" name="sodium_current_p_Na_gate">
<variable cmeta:id="id_00042" name="p_Na" public_interface="out" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="p_Na_calculation">
<eq/>
<ci> p_Na </ci>
<apply>
<divide/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="millivolt"> 104.0 </cn>
<ci> V </ci>
</apply>
<cn cellml:units="millivolt"> 8.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00046" name="sodium_potassium_active_transport">
<variable cmeta:id="id_00047" name="i_NaK" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00048" initial_value="600.0" name="P_NaK" units="femtoA"/>
<variable initial_value="4950.0" name="P" units="micromolar"/>
<variable name="K_supi" units="micromolar"/>
<variable name="F1" units="first_order_rate_constant"/>
<variable name="F4" units="first_order_rate_constant"/>
<variable name="F5" units="first_order_rate_constant"/>
<variable initial_value="2.5E-10" name="f1" units="forth_order_rate_constant"/>
<variable initial_value="10.0" name="f2" units="first_order_rate_constant"/>
<variable initial_value="0.172" name="f3" units="first_order_rate_constant"/>
<variable initial_value="1.5E-8" name="f4" units="third_order_rate_constant"/>
<variable initial_value="0.002" name="f5_" units="second_order_rate_constant"/>
<variable name="f5" units="second_order_rate_constant"/>
<variable initial_value="11.5" name="f6" units="first_order_rate_constant"/>
<variable initial_value="100.0" name="b1" units="first_order_rate_constant"/>
<variable initial_value="0.0001" name="b2" units="second_order_rate_constant"/>
<variable initial_value="1.72E-17" name="b3" units="forth_order_rate_constant"/>
<variable initial_value="0.0002" name="b4" units="second_order_rate_constant"/>
<variable initial_value="0.03" name="b5_" units="first_order_rate_constant"/>
<variable name="b5" units="first_order_rate_constant"/>
<variable initial_value="6.0E-7" name="b6" units="second_order_rate_constant"/>
<variable name="B2" units="first_order_rate_constant"/>
<variable name="B3" units="first_order_rate_constant"/>
<variable name="B4" units="first_order_rate_constant"/>
<variable name="B6" units="first_order_rate_constant"/>
<variable name="D" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Nai" public_interface="in" units="micromolar"/>
<variable name="Nao" public_interface="in" units="micromolar"/>
<variable name="ATPi" public_interface="in" units="micromolar"/>
<variable name="ADPi" public_interface="in" units="micromolar"/>
<variable name="Ko" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_NaK_calculation">
<eq/>
<ci> i_NaK </ci>
<apply>
<times/>
<ci> P_NaK </ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> F1 </ci>
<ci> f2 </ci>
<ci> f3 </ci>
<ci> F4 </ci>
<ci> F5 </ci>
<ci> f6 </ci>
</apply>
<apply>
<times/>
<ci> b1 </ci>
<ci> B2 </ci>
<ci> B3 </ci>
<ci> B4 </ci>
<ci> b5 </ci>
<ci> B6 </ci>
</apply>
</apply>
<ci> D </ci>
</apply>
</apply>
</apply>
<apply id="D_calculation">
<eq/>
<ci> D </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> f2 </ci>
<ci> f3 </ci>
<ci> F4 </ci>
<ci> F5 </ci>
<ci> f6 </ci>
</apply>
<apply>
<times/>
<ci> b1 </ci>
<ci> f3 </ci>
<ci> F4 </ci>
<ci> F5 </ci>
<ci> f6 </ci>
</apply>
<apply>
<times/>
<ci> b1 </ci>
<ci> B2 </ci>
<ci> F4 </ci>
<ci> F5 </ci>
<ci> f6 </ci>
</apply>
<apply>
<times/>
<ci> b1 </ci>
<ci> B2 </ci>
<ci> B3 </ci>
<ci> F5 </ci>
<ci> f6 </ci>
</apply>
<apply>
<times/>
<ci> b1 </ci>
<ci> B2 </ci>
<ci> B3 </ci>
<ci> B4 </ci>
<ci> f6 </ci>
</apply>
<apply>
<times/>
<ci> b1 </ci>
<ci> B2 </ci>
<ci> B3 </ci>
<ci> B4 </ci>
<ci> b5 </ci>
</apply>
</apply>
</apply>
<apply id="F1_calculation">
<eq/>
<ci> F1 </ci>
<apply>
<times/>
<ci> f1 </ci>
<apply>
<power/>
<ci> Nai </ci>
<cn cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
<apply id="F4_calculation">
<eq/>
<ci> F4 </ci>
<apply>
<times/>
<ci> f4 </ci>
<apply>
<power/>
<ci> Ko </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
<apply id="F5_calculation">
<eq/>
<ci> F5 </ci>
<apply>
<times/>
<ci> f5 </ci>
<ci> ATPi </ci>
</apply>
</apply>
<apply id="f5_calculation">
<eq/>
<ci> f5 </ci>
<apply>
<times/>
<ci> f5_ </ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci> V </ci>
<ci> F </ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="B2_calculation">
<eq/>
<ci> B2 </ci>
<apply>
<times/>
<ci> b2 </ci>
<ci> ATPi </ci>
</apply>
</apply>
<apply id="B3_calculation">
<eq/>
<ci> B3 </ci>
<apply>
<times/>
<ci> b3 </ci>
<apply>
<power/>
<ci> Nai </ci>
<cn cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
<apply id="B4_calculation">
<eq/>
<ci> B4 </ci>
<apply>
<times/>
<ci> b4 </ci>
<ci> P </ci>
</apply>
</apply>
<apply id="B6_calculation">
<eq/>
<ci> B6 </ci>
<apply>
<times/>
<ci> b6 </ci>
<apply>
<power/>
<ci> K_supi </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
<apply id="b5_calculation">
<eq/>
<ci> b5 </ci>
<apply>
<times/>
<ci> b5_ </ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> V </ci>
<ci> F </ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci> R </ci>
<ci> T </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00052" name="voltage_dependent_potassium_current">
<variable cmeta:id="id_00053" name="i_KDr" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00054" name="V_K" public_interface="out" units="millivolt"/>
<variable cmeta:id="id_00055" initial_value="3000.0" name="gm_KDr" units="picoS"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="Ki" public_interface="in" units="micromolar"/>
<variable name="Ko" public_interface="in" units="micromolar"/>
<variable name="n" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_KDr_calculation">
<eq/>
<ci> i_KDr </ci>
<apply>
<times/>
<ci> gm_KDr </ci>
<ci> n </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> V_K </ci>
</apply>
</apply>
</apply>
<apply id="V_K_calculation">
<eq/>
<ci> V_K </ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci> R </ci>
<ci> T </ci>
</apply>
<ci> F </ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci> Ko </ci>
<ci> Ki </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00056" name="voltage_dependent_potassium_current_n_gate">
<variable cmeta:id="id_00057" initial_value="0.00123" name="n" public_interface="out" units="dimensionless"/>
<variable cmeta:id="id_00058" name="tau_n" units="dimensionless"/>
<variable cmeta:id="id_00059" name="n_infinity" units="dimensionless"/>
<variable cmeta:id="id_00060" initial_value="-14.0" name="Vn" units="millivolt"/>
<variable cmeta:id="id_00061" initial_value="-75.0" name="Vtau" units="millivolt"/>
<variable cmeta:id="id_00062" initial_value="7.0" name="Sn" units="millivolt"/>
<variable initial_value="65.0" name="a" units="millivolt"/>
<variable initial_value="20.0" name="b" units="millivolt"/>
<variable initial_value="20.0" name="c" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="n_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> n </ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci> n_infinity </ci>
<ci> n </ci>
</apply>
<ci> tau_n </ci>
</apply>
</apply>
<apply id="n_infinity_calculation">
<eq/>
<ci> n_infinity </ci>
<apply>
<divide/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci> Vn </ci>
<ci> V </ci>
</apply>
<ci> Sn </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="tau_n_calculation">
<eq/>
<ci> tau_n </ci>
<apply>
<divide/>
<ci> c </ci>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci> V </ci>
<ci> Vtau </ci>
</apply>
<ci> a </ci>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci> Vtau </ci>
<ci> V </ci>
</apply>
<ci> b </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00069" name="calcium_dependent_potassium_current">
<variable cmeta:id="id_00070" name="i_KCa" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00071" initial_value="130.0" name="gm_KCa" units="picoS"/>
<variable cmeta:id="id_00072" name="V_K" public_interface="in" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="Cai" private_interface="out" public_interface="in" units="micromolar"/>
<variable name="fCa" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_KCa_calculation">
<eq/>
<ci> i_KCa </ci>
<apply>
<times/>
<ci> gm_KCa </ci>
<ci> fCa </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> V_K </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00073" name="calcium_dependent_potassium_current_fCa_gate">
<variable cmeta:id="id_00074" name="fCa" public_interface="out" units="dimensionless"/>
<variable cmeta:id="id_00075" initial_value="0.1" name="K_KCa" units="micromolar"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="fCa_calculation">
<eq/>
<ci> fCa </ci>
<apply>
<divide/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 4.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 4.0 </cn>
</apply>
<apply>
<power/>
<ci> K_KCa </ci>
<cn cellml:units="dimensionless"> 4.0 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00063" name="ATP_dependent_potassium_current">
<variable cmeta:id="id_00064" name="i_KATP" public_interface="out" units="femtoA"/>
<variable cmeta:id="id_00065" initial_value="24000.0" name="gm_KATP" units="picoS"/>
<variable cmeta:id="id_00066" name="O_KATP" units="dimensionless"/>
<variable initial_value="17.0" name="Kdd" units="micromolar"/>
<variable initial_value="26.0" name="Ktd" units="micromolar"/>
<variable initial_value="1.0" name="Ktt" units="micromolar"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="V_K" public_interface="in" units="millivolt"/>
<variable name="ADPi" public_interface="in" units="micromolar"/>
<variable name="ATPi" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="i_KATP_calculation">
<eq/>
<ci> i_KATP </ci>
<apply>
<times/>
<ci> gm_KATP </ci>
<ci> O_KATP </ci>
<apply>
<minus/>
<ci> V </ci>
<ci> V_K </ci>
</apply>
</apply>
</apply>
<apply id="O_KATP_calculation">
<eq/>
<ci> O_KATP </ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 0.08 </cn>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 0.33 </cn>
<ci> ADPi </ci>
</apply>
<ci> Kdd </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 0.89 </cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 0.165 </cn>
<apply>
<divide/>
<ci> ADPi </ci>
<ci> Kdd </ci>
</apply>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 0.165 </cn>
<apply>
<divide/>
<ci> ADPi </ci>
<ci> Kdd </ci>
</apply>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 0.135 </cn>
<ci> ADPi </ci>
</apply>
<ci> Ktd </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 0.05 </cn>
<ci> ATPi </ci>
</apply>
<ci> Ktt </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00077" name="SERCA_pump">
<variable cmeta:id="id_00078" name="Jer_p" public_interface="out" units="flux"/>
<variable cmeta:id="id_00079" initial_value="0.105" name="P_CaER" units="flux"/>
<variable cmeta:id="id_00080" initial_value="0.5" name="K_Carp" units="micromolar"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Jer_p_calculation">
<eq/>
<ci> Jer_p </ci>
<apply>
<times/>
<ci> P_CaER </ci>
<apply>
<divide/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<power/>
<ci> K_Carp </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00081" name="IP3_metabolism">
<variable cmeta:id="id_00082" initial_value="0.33" name="IP3i" public_interface="out" units="micromolar"/>
<variable initial_value="0.0003" name="kIP" units="flux"/>
<variable initial_value="0.00004" name="kdIP" units="first_order_rate_constant"/>
<variable cmeta:id="id_00083" initial_value="0.4" name="K_IPCa" units="micromolar"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="IP3_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> IP3i </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> kIP </ci>
<apply>
<divide/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci> Cai </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<power/>
<ci> K_IPCa </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> kdIP </ci>
<ci> IP3i </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CaER_mobilisation">
<variable name="J_out" public_interface="out" units="flux"/>
<variable cmeta:id="id_00087" initial_value="0.0001" name="P_leak" units="picol_per_ms"/>
<variable cmeta:id="id_00086" initial_value="0.0012" name="P_IP3" units="picol_per_ms"/>
<variable name="O_infinity" units="dimensionless"/>
<variable initial_value="3.2" name="K_RCa" units="micromolar"/>
<variable cmeta:id="id_00084" initial_value="0.077" name="K_IP3" units="micromolar"/>
<variable cmeta:id="id_00085" name="IP3i" public_interface="in" units="micromolar"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable name="CaER" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> J_out </ci>
<apply>
<times/>
<apply>
<plus/>
<ci> P_leak </ci>
<apply>
<times/>
<ci> P_IP3 </ci>
<ci> O_infinity </ci>
</apply>
</apply>
<apply>
<minus/>
<ci> CaER </ci>
<ci> Cai </ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> O_infinity </ci>
<apply>
<times/>
<apply>
<divide/>
<ci> Cai </ci>
<apply>
<plus/>
<ci> Cai </ci>
<ci> K_RCa </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<power/>
<ci> IP3i </ci>
<cn cellml:units="dimensionless"> 3.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci> IP3i </ci>
<cn cellml:units="dimensionless"> 3.0 </cn>
</apply>
<apply>
<power/>
<ci> K_IP3 </ci>
<cn cellml:units="dimensionless"> 3.0 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00044" name="calcium_and_sodium_dynamics">
<variable initial_value="0.085" name="Cai" public_interface="out" units="micromolar"/>
<variable initial_value="22.8" name="CaER" public_interface="out" units="micromolar"/>
<variable initial_value="9858.0" name="Nai" public_interface="out" units="micromolar"/>
<variable initial_value="0.01" name="fi" units="dimensionless"/>
<variable initial_value="0.03" name="fer" units="dimensionless"/>
<variable initial_value="0.0001" name="ksg" units="first_order_rate_constant"/>
<variable initial_value="0.280" name="Ver" units="picol"/>
<variable name="Vi" public_interface="in" units="picol"/>
<variable cmeta:id="id_00021" name="i_VCa" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00034" name="i_NaCa" public_interface="in" units="femtoA"/>
<variable name="i_Ca_pump" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00049" name="i_NaK" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00043" name="i_Na" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00011" name="i_CRAN" public_interface="in" units="femtoA"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="J_out" public_interface="in" units="flux"/>
<variable name="Jer_p" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="Cai_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> Cai </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> fi </ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci> i_VCa </ci>
</apply>
<apply>
<times/>
<ci> i_NaCa </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> i_Ca_pump </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci> F </ci>
<ci> Vi </ci>
</apply>
</apply>
<ci> Jer_p </ci>
</apply>
<apply>
<divide/>
<ci> J_out </ci>
<ci> Vi </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> ksg </ci>
<ci> Cai </ci>
</apply>
</apply>
</apply>
<apply id="CaER_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> CaER </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> fer </ci>
<ci> Ver </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> Jer_p </ci>
<ci> Vi </ci>
</apply>
<ci> J_out </ci>
</apply>
</apply>
</apply>
<apply id="Nai_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> Nai </ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 3.0 </cn>
<ci> i_NaCa </ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 3.0 </cn>
<ci> i_NaK </ci>
</apply>
<ci> i_Na </ci>
<ci> i_CRAN </ci>
</apply>
</apply>
<apply>
<times/>
<ci> Vi </ci>
<ci> F </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00090" name="ATP_homeostasis">
<variable cmeta:id="id_00088" initial_value="932.1" name="ATPi" public_interface="out" units="micromolar"/>
<variable cmeta:id="id_00091" name="ADPi" public_interface="out" units="millimolar"/>
<variable cmeta:id="id_00092" name="k_ADP" units="first_order_rate_constant"/>
<variable cmeta:id="id_00067" initial_value="0.00005" name="k_ATP" units="first_order_rate_constant"/>
<variable cmeta:id="id_00089" initial_value="0.00005" name="k_ATP_Ca" units="second_order_rate_constant"/>
<variable initial_value="4000.0" name="Ao" units="micromolar"/>
<variable name="Vi" public_interface="in" units="picol"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable cmeta:id="id_00027" name="i_Ca_pump" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00010" name="i_CRAN" public_interface="in" units="femtoA"/>
<variable cmeta:id="id_00050" name="i_NaK" public_interface="in" units="femtoA"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="Jer_p" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="ATPi_diff_eq">
<eq/>
<apply>
<diff/>
<bvar>
<ci> time </ci>
</bvar>
<ci> ATPi </ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> k_ADP </ci>
<ci> ADPi </ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<ci> i_NaK </ci>
<ci> i_CRAN </ci>
</apply>
<apply>
<times/>
<ci> Vi </ci>
<ci> F </ci>
</apply>
</apply>
<apply>
<divide/>
<ci> Jer_p </ci>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> k_ATP_Ca </ci>
<ci> Cai </ci>
</apply>
<ci> k_ATP </ci>
</apply>
<ci> ATPi </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> ADPi </ci>
<apply>
<minus/>
<ci> Ao </ci>
<ci> ATPi </ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00093" name="cell_and_external_parameters">
<variable initial_value="2.6" name="Cao" public_interface="out" units="millimolar"/>
<variable initial_value="140.0" name="Nao" public_interface="out" units="millimolar"/>
<variable initial_value="8.0" name="Ko" public_interface="out" units="millimolar"/>
<variable initial_value="132.4" name="Ki" public_interface="out" units="millimolar"/>
<variable initial_value="8314.0" name="R" public_interface="out" units="joule_per_kilomole_kelvin"/>
<variable initial_value="310.0" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96500.0" name="F" public_interface="out" units="coulomb_per_mole"/>
<variable initial_value="0.764" name="Vi" public_interface="out" units="picol"/>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="whole_cell_calcium_current">
<component_ref component="whole_cell_calcium_current_p_VCa_gate"/>
</component_ref>
<component_ref component="PM_calcium_pumps"/>
<component_ref component="sodium_calcium_exchanger"/>
<component_ref component="nonselective_cation_current"/>
<component_ref component="sodium_current">
<component_ref component="sodium_current_p_Na_gate"/>
</component_ref>
<component_ref component="voltage_dependent_potassium_current">
<component_ref component="voltage_dependent_potassium_current_n_gate"/>
</component_ref>
<component_ref component="calcium_dependent_potassium_current">
<component_ref component="calcium_dependent_potassium_current_fCa_gate"/>
</component_ref>
<component_ref component="sodium_potassium_active_transport"/>
<component_ref component="ATP_dependent_potassium_current"/>
<component_ref component="SERCA_pump"/>
<component_ref component="IP3_metabolism"/>
<component_ref component="CaER_mobilisation"/>
<component_ref component="calcium_and_sodium_dynamics"/>
<component_ref component="ATP_homeostasis"/>
<component_ref component="cell_and_external_parameters"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="whole_cell_calcium_current">
<component_ref component="whole_cell_calcium_current_p_VCa_gate"/>
</component_ref>
<component_ref component="sodium_current">
<component_ref component="sodium_current_p_Na_gate"/>
</component_ref>
<component_ref component="voltage_dependent_potassium_current">
<component_ref component="voltage_dependent_potassium_current_n_gate"/>
</component_ref>
<component_ref component="calcium_dependent_potassium_current">
<component_ref component="calcium_dependent_potassium_current_fCa_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="IP3_metabolism" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ATP_homeostasis" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="voltage_dependent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="whole_cell_calcium_current"/>
<map_variables variable_1="i_VCa" variable_2="i_VCa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="PM_calcium_pumps"/>
<map_variables variable_1="i_Ca_pump" variable_2="i_Ca_pump"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_active_transport"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="nonselective_cation_current"/>
<map_variables variable_1="i_CRAN" variable_2="i_CRAN"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="voltage_dependent_potassium_current"/>
<map_variables variable_1="i_KDr" variable_2="i_KDr"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_dependent_potassium_current"/>
<map_variables variable_1="i_KCa" variable_2="i_KCa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ATP_dependent_potassium_current"/>
<map_variables variable_1="i_KATP" variable_2="i_KATP"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="whole_cell_calcium_current"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_VCa" variable_2="i_VCa"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="PM_calcium_pumps"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_Ca_pump" variable_2="i_Ca_pump"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="sodium_potassium_active_transport"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="nonselective_cation_current"/>
<map_variables variable_1="CaER" variable_2="CaER"/>
<map_variables variable_1="i_CRAN" variable_2="i_CRAN"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="sodium_current"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="calcium_dependent_potassium_current"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="SERCA_pump"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Jer_p" variable_2="Jer_p"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="IP3_metabolism"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="CaER_mobilisation"/>
<map_variables variable_1="CaER" variable_2="CaER"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="J_out" variable_2="J_out"/>
</connection>
<connection>
<map_components component_1="calcium_and_sodium_dynamics" component_2="ATP_homeostasis"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="whole_cell_calcium_current"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="sodium_calcium_exchanger"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="sodium_potassium_active_transport"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="sodium_current"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="voltage_dependent_potassium_current"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="calcium_and_sodium_dynamics"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Vi" variable_2="Vi"/>
</connection>
<connection>
<map_components component_1="cell_and_external_parameters" component_2="ATP_homeostasis"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Vi" variable_2="Vi"/>
</connection>
<connection>
<map_components component_1="nonselective_cation_current" component_2="sodium_current"/>
<map_variables variable_1="V_Na" variable_2="V_Na"/>
</connection>
<connection>
<map_components component_1="voltage_dependent_potassium_current" component_2="calcium_dependent_potassium_current"/>
<map_variables variable_1="V_K" variable_2="V_K"/>
</connection>
<connection>
<map_components component_1="voltage_dependent_potassium_current" component_2="ATP_dependent_potassium_current"/>
<map_variables variable_1="V_K" variable_2="V_K"/>
</connection>
<connection>
<map_components component_1="IP3_metabolism" component_2="CaER_mobilisation"/>
<map_variables variable_1="IP3i" variable_2="IP3i"/>
</connection>
<connection>
<map_components component_1="ATP_homeostasis" component_2="PM_calcium_pumps"/>
<map_variables variable_1="i_Ca_pump" variable_2="i_Ca_pump"/>
</connection>
<connection>
<map_components component_1="ATP_homeostasis" component_2="sodium_potassium_active_transport"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="ATPi" variable_2="ATPi"/>
<map_variables variable_1="ADPi" variable_2="ADPi"/>
</connection>
<connection>
<map_components component_1="ATP_homeostasis" component_2="SERCA_pump"/>
<map_variables variable_1="Jer_p" variable_2="Jer_p"/>
</connection>
<connection>
<map_components component_1="ATP_homeostasis" component_2="ATP_dependent_potassium_current"/>
<map_variables variable_1="ATPi" variable_2="ATPi"/>
<map_variables variable_1="ADPi" variable_2="ADPi"/>
</connection>
<connection>
<map_components component_1="ATP_homeostasis" component_2="nonselective_cation_current"/>
<map_variables variable_1="i_CRAN" variable_2="i_CRAN"/>
</connection>
<connection>
<map_components component_1="whole_cell_calcium_current" component_2="whole_cell_calcium_current_p_VCa_gate"/>
<map_variables variable_1="p_VCa" variable_2="p_VCa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_p_Na_gate"/>
<map_variables variable_1="p_Na" variable_2="p_Na"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="voltage_dependent_potassium_current" component_2="voltage_dependent_potassium_current_n_gate"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="calcium_dependent_potassium_current" component_2="calcium_dependent_potassium_current_fCa_gate"/>
<map_variables variable_1="fCa" variable_2="fCa"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<rdf:RDF><rdf:Description rdf:about="#id_00001"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0042391"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0060075"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0030322"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00002"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00003"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00004"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00005"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00006"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00007"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00008"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00009"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00010"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00011"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005227"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00012"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00013"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00014"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00015"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00016"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00017"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00018"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00019"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00020"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00021"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00022"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00023"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00024"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00025"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00026"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00027"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070588"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015085"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006816"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00028"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0030181"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00029"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0030181"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00030"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0030181"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00031"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0030181"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00032"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0030181"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00033"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0030181"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00034"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0030181"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00035"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00036"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00037"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00038"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00039"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00040"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00041"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00042"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00043"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00044"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005262"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034704"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005245"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005891"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005272"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034706"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005248"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0001518"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00045"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005391"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005890"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00046"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005391"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005890"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006815"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00047"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005391"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005890"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006815"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00048"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005391"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005890"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006815"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00049"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005391"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005890"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00050"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005391"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005890"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0006815"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00051"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00052"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00053"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00054"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00055"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00056"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00057"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00058"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00059"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00060"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00061"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00062"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00063"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008282"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00064"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008282"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00065"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008282"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00066"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005267"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0034705"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005249"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008076"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008282"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00067"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008282"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:15422"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00068"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015269"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00069"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015269"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00070"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015269"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00071"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015269"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00072"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015269"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00073"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015269"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00074"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015269"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00075"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0015269"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00076"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0008282"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00077"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0051208"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070296"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00078"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0051208"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070296"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00079"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0051208"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070296"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00080"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0051208"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0070296"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00081"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005220"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00082"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005220"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00083"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005220"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00084"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005220"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00085"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005220"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00086"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0005220"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00087"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/go/GO:0022840"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00088"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:15422"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00089"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:15422"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00090"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:15422"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00091"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:16761"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00092"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:16761"/></isVersionOf></rdf:Description><rdf:Description rdf:about="#id_00093"><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:26708"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:26216"/></isVersionOf><isVersionOf xmlns="http://biomodels.net/biology-qualifiers/"><rdf:Description rdf:about="http://identifiers.org/chebi/CHEBI:39124"/></isVersionOf></rdf:Description></rdf:RDF></model>
