Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons
Geoffrey
Nunns
Auckland Bioengineering Institute, The University of Auckland
Model Status
This model runs in both OpenCell and COR and the units are consistent. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.
Model Structure
Abstract: We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.
model diagram
Schematic diagram of the Dougherty et al model.
The complete original paper reference is cited below:
Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons, Daniel P. Dougherty, Geraldine A. Wright, Alice C. Yew, 2005,
Proceeding of the National Academy of Sciences
, 102, 10415- 10420. PubMed ID: 16027364
Proceedings of the National Academy of Sciences
Geoffrey
Nunns
Rogan
Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons
102
10415
10420
Geoffrey
Nunns
Rogan
gnunns1@jhem.jhu.edu
2008-07-17T15:04:20+12:00
Geraldine
Wright
A
This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.
This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.
16027364
Fixed "not exactly equivalent but dimensionally equivalent" errors.
Geoff Nunns
2008-06-25T00:00:00+00:00
Alice
Yew
C
The University of Auckland
Auckland Bioengineering Institute
Geoff Nunns
2005-05-25 00:00
keyword
calcium dynamics
signal transduction
Daniel
Dougherty
P