Location: Bondarenko, Szigeti, Bett, Kim, Rasmusson, 2004 @ 5019e4a76196 / bondarenko_szigeti_bett_kim_rasmusson_2004_apical.cellml

Author:
Dougal Cowan <devnull@localhost>
Date:
2011-04-27 08:40:25+12:00
Desc:
removed file:// references from the session files
Permanent Source URI:
https://models.physiomeproject.org/workspace/bondarenko_szigeti_bett_kim_rasmusson_2004/rawfile/5019e4a76196c45cb6ff3fcfb136f3196b697ae8/bondarenko_szigeti_bett_kim_rasmusson_2004_apical.cellml

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<!--
This CellML file was generated on 04/12/2007 at 15:20:38 using:

COR (0.9.31.821)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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<documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <articleinfo>
        <title>Computer model of action potential of mouse ventricular myocytes</title>
        <author>
          <firstname>Noble</firstname>
          <surname>Penny</surname>
          <affiliation>
            <shortaffil>Oxford University</shortaffil>
          </affiliation>
        </author>
      </articleinfo>
      <section id="sec_status">
        <title>Model Status</title>
        <para>
            This CellML model runs in both OpenCell and COR to reproduce the the action potential traces from Figure 16 of the publication. This model represents the APICAL CELL variant as described in Bondarenko et al.'s 2004 paper.
</para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>
ABSTRACT: We have developed a mathematical model of the mouse ventricular myocyte action potential (AP) from voltage-clamp data of the underlying currents and Ca2+ transients. Wherever possible, we used Markov models to represent the molecular structure and function of ion channels. The model includes detailed intracellular Ca2+ dynamics, with simulations of localized events such as sarcoplasmic Ca2+ release into a small intracellular volume bounded by the sarcolemma and sarcoplasmic reticulum. Transporter-mediated Ca2+ fluxes from the bulk cytosol are closely matched to the experimentally reported values and predict stimulation rate-dependent changes in Ca2+ transients. Our model reproduces the properties of cardiac myocytes from two different regions of the heart: the apex and the septum. The septum has a relatively prolonged AP, which reflects a relatively small contribution from the rapid transient outward K+ current in the septum. The attribution of putative molecular bases for several of the component currents enables our mouse model to be used to simulate the behavior of genetically modified transgenic mice.
</para>
        
        <para>
The original paper reference is cited below:
</para>
        <para>
          Computer model of action potential of mouse ventricular myocytes, Vladimir E. Bondarenko, Gyula P. Szigeti, Glenna C. L. Bett, Song-Jung Kim, and Randall L. Rasmusson, 2004,
            <emphasis>American Journal of Physiology</emphasis>, 287, H1378-H1403. 
         <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/15142845">PubMed ID: 15142845</ulink>
        </para>
        <informalfigure float="0" id="fig_cell_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>cell diagram</title>
              </objectinfo>
              <imagedata fileref="bondarenko_2004.png"/>
            </imageobject>
          </mediaobject>
          <caption>Schematic diagram of the mouse model ionic currents and calcium fluxes.</caption>
        </informalfigure>
        <informalfigure float="0" id="fig_reaction_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>reaction diagram</title>
              </objectinfo>
              <imagedata fileref="bondarenko_2_2004.png"/>
            </imageobject>
          </mediaobject>
          <caption>State diagram of the Markov model for the sodium channel.  <emphasis>C<subscript>Na</subscript>
            </emphasis> denotes a closed channel state, <emphasis>O<subscript>Na</subscript>
            </emphasis> is the open state, <emphasis>IF<subscript>Na</subscript>
            </emphasis> represents the fast, inactivated state, <emphasis>I1<subscript>Na</subscript>
            </emphasis> and <emphasis>I2<subscript>Na</subscript>
            </emphasis> are the intermediate inactivated states, and <emphasis>IC2<subscript>Na</subscript>
            </emphasis> and <emphasis>IC3<subscript>Na</subscript>
            </emphasis> are the closed-inactivation states.</caption>
        </informalfigure>
      </sect1>
    </article>
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      <variable name="Cai" public_interface="in" units="micromolar"/>
      <variable name="Cass" public_interface="in" units="micromolar"/>
      <variable name="CaJSR" public_interface="in" units="micromolar"/>
      <variable name="CaNSR" public_interface="in" units="micromolar"/>
      <variable name="P_O1" public_interface="in" units="dimensionless"/>
      <variable name="P_O2" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>J_rel</ci>
            <apply>
               <times/>
               <ci>v1</ci>
               <apply>
                  <plus/>
                  <ci>P_O1</ci>
                  <ci>P_O2</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>CaJSR</ci>
                  <ci>Cass</ci>
               </apply>
               <ci>P_RyR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>CaNSR</ci>
                  <ci>CaJSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_xfer</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Cass</ci>
                  <ci>Cai</ci>
               </apply>
               <ci>tau_xfer</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_leak</ci>
            <apply>
               <times/>
               <ci>v2</ci>
               <apply>
                  <minus/>
                  <ci>CaNSR</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>v3</ci>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>Km_up</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_trpn</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>k_plus_htrpn</ci>
                     <ci>Cai</ci>
                     <apply>
                        <minus/>
                        <ci>HTRPN_tot</ci>
                        <ci>HTRPN_Ca</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_plus_ltrpn</ci>
                     <ci>Cai</ci>
                     <apply>
                        <minus/>
                        <ci>LTRPN_tot</ci>
                        <ci>LTRPN_Ca</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>k_minus_htrpn</ci>
                     <ci>HTRPN_Ca</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_minus_ltrpn</ci>
                     <ci>LTRPN_Ca</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_RyR</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.04</cn>
                  </apply>
                  <ci>P_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.1</cn>
                        <ci>i_CaL</ci>
                     </apply>
                     <ci>i_CaL_max</ci>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">648</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_buffering">
      <variable initial_value="70" name="LTRPN_tot" public_interface="out" units="micromolar"/>
      <variable initial_value="140" name="HTRPN_tot" public_interface="out" units="micromolar"/>
      <variable initial_value="11.2684" name="LTRPN_Ca" public_interface="out" units="micromolar"/>
      <variable initial_value="125.29" name="HTRPN_Ca" public_interface="out" units="micromolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <variable name="k_plus_htrpn" public_interface="in" units="per_micromolar_millisecond"/>
      <variable name="k_minus_htrpn" public_interface="in" units="per_millisecond"/>
      <variable name="k_plus_ltrpn" public_interface="in" units="per_micromolar_millisecond"/>
      <variable name="k_minus_ltrpn" public_interface="in" units="per_millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>LTRPN_Ca</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_plus_ltrpn</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>LTRPN_tot</ci>
                     <ci>LTRPN_Ca</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k_minus_ltrpn</ci>
                  <ci>LTRPN_Ca</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>HTRPN_Ca</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_plus_htrpn</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>HTRPN_tot</ci>
                     <ci>HTRPN_Ca</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k_minus_htrpn</ci>
                  <ci>HTRPN_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ryanodine_receptors">
      <variable initial_value="0.149102e-4" name="P_O1" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.951726e-10" name="P_O2" public_interface="out" units="dimensionless"/>
      <variable name="P_C1" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.16774e-3" name="P_C2" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.006075" name="k_plus_a" units="micromolar4_per_millisecond"/>
      <variable initial_value="0.07125" name="k_minus_a" units="per_millisecond"/>
      <variable initial_value="0.00405" name="k_plus_b" units="micromolar3_per_millisecond"/>
      <variable initial_value="0.965" name="k_minus_b" units="per_millisecond"/>
      <variable initial_value="0.009" name="k_plus_c" units="per_millisecond"/>
      <variable initial_value="0.0008" name="k_minus_c" units="per_millisecond"/>
      <variable initial_value="3" name="m" units="dimensionless"/>
      <variable initial_value="4" name="n" units="dimensionless"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="Cass" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_O1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>k_plus_a</ci>
                     <apply>
                        <power/>
                        <ci>Cass</ci>
                        <ci>n</ci>
                     </apply>
                     <ci>P_C1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_minus_b</ci>
                     <ci>P_O2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_minus_c</ci>
                     <ci>P_C2</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>k_minus_a</ci>
                     <ci>P_O1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_plus_b</ci>
                     <apply>
                        <power/>
                        <ci>Cass</ci>
                        <ci>m</ci>
                     </apply>
                     <ci>P_O1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k_plus_c</ci>
                     <ci>P_O1</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_C1</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>P_C2</ci>
                  <ci>P_O1</ci>
                  <ci>P_O2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_O2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_plus_b</ci>
                  <apply>
                     <power/>
                     <ci>Cass</ci>
                     <ci>m</ci>
                  </apply>
                  <ci>P_O1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_minus_b</ci>
                  <ci>P_O2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_C2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_plus_c</ci>
                  <ci>P_O1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_minus_c</ci>
                  <ci>P_C2</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_calcium_current">
      <variable cmeta:id="L_type_calcium_current_i_CaL" name="i_CaL" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="7" name="i_CaL_max" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="63" name="E_CaL" public_interface="out" units="millivolt"/>
      <variable initial_value="0.1729" name="g_CaL" units="milliS_per_microF"/>
      <variable initial_value="0.930308e-18" name="O" units="dimensionless"/>
      <variable name="C1" units="dimensionless"/>
      <variable initial_value="0.124216e-3" name="C2" units="dimensionless"/>
      <variable initial_value="0.578679e-8" name="C3" units="dimensionless"/>
      <variable initial_value="0.119816e-12" name="C4" units="dimensionless"/>
      <variable initial_value="0.497923e-18" name="I1" units="dimensionless"/>
      <variable initial_value="0.345847e-13" name="I2" units="dimensionless"/>
      <variable initial_value="0.185106e-13" name="I3" units="dimensionless"/>
      <variable name="alpha" units="per_millisecond"/>
      <variable name="beta" units="per_millisecond"/>
      <variable name="gamma" units="per_millisecond"/>
      <variable name="Kpcf" units="per_millisecond"/>
      <variable initial_value="0.0005" name="Kpcb" units="per_millisecond"/>
      <variable initial_value="0.23324" name="Kpc_max" units="per_millisecond"/>
      <variable initial_value="20" name="Kpc_half" units="micromolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Cass" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_CaL</ci>
            <apply>
               <times/>
               <ci>g_CaL</ci>
               <ci>O</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_CaL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha</ci>
                     <ci>C4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpcb</ci>
                     <ci>I1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>I2</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>O</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>beta</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <ci>O</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C1</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>O</ci>
                  <ci>C2</ci>
                  <ci>C3</ci>
                  <ci>C4</ci>
                  <ci>I1</ci>
                  <ci>I2</ci>
                  <ci>I3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>alpha</ci>
                     <ci>C1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>beta</ci>
                     <ci>C3</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta</ci>
                     <ci>C2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>alpha</ci>
                     <ci>C2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>alpha</ci>
                     <ci>C2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>beta</ci>
                     <ci>C4</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>beta</ci>
                     <ci>C3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>alpha</ci>
                     <ci>C3</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C4</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>alpha</ci>
                     <ci>C3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>beta</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.01</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>Kpcb</ci>
                           <ci>beta</ci>
                           <ci>I1</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>gamma</ci>
                           <ci>C4</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.002</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>beta</ci>
                           <ci>I2</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>C4</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">4</cn>
                     <ci>beta</ci>
                     <ci>Kpcb</ci>
                     <ci>I3</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>beta</ci>
                     <ci>C4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha</ci>
                     <ci>C4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                     <ci>gamma</ci>
                     <ci>Kpcf</ci>
                     <ci>C4</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>I3</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>I1</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.01</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>gamma</ci>
                           <ci>C4</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>beta</ci>
                           <ci>Kpcf</ci>
                           <ci>I1</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>Kpcb</ci>
                  <ci>I1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>O</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>I2</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpcb</ci>
                     <ci>I3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.002</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>C4</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>beta</ci>
                           <ci>I2</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>gamma</ci>
                  <ci>I2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>Kpcf</ci>
                           <ci>I1</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>alpha</ci>
                           <ci>I3</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <ci>I2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1</cn>
                     <ci>gamma</ci>
                     <ci>Kpcf</ci>
                     <ci>C4</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">4</cn>
                     <ci>beta</ci>
                     <ci>Kpcb</ci>
                     <ci>I3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>Kpcb</ci>
                     <ci>I3</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.4</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.7</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <power/>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                                       </apply>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">10</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.75</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <power/>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">400</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.05</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gamma</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Kpc_max</ci>
                  <ci>Cass</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Kpc_half</ci>
                  <ci>Cass</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Kpcf</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">13</cn>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.5</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">100</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_pump_current">
      <variable cmeta:id="calcium_pump_current_i_pCa" name="i_pCa" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="1" name="i_pCa_max" units="picoA_per_picoF"/>
      <variable initial_value="0.5" name="Km_pCa" units="micromolar"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_pCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_pCa_max</ci>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>Km_pCa</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_calcium_exchange_current">
      <variable cmeta:id="sodium_calcium_exchange_current_i_NaCa" name="i_NaCa" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="292.8" name="k_NaCa" units="picoA_per_picoF"/>
      <variable initial_value="87500" name="K_mNa" units="micromolar"/>
      <variable initial_value="1380" name="K_mCa" units="micromolar"/>
      <variable initial_value="0.1" name="k_sat" units="dimensionless"/>
      <variable initial_value="0.35" name="eta" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Nai" public_interface="in" units="micromolar"/>
      <variable name="Nao" public_interface="in" units="micromolar"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <variable name="Cao" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>k_NaCa</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <power/>
                                    <ci>K_mNa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                                 <apply>
                                    <power/>
                                    <ci>Nao</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>K_mCa</ci>
                           <ci>Cao</ci>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <ci>k_sat</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>eta</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>eta</ci>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Nai</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>Cao</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>eta</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable cmeta:id="calcium_background_current_i_Cab" name="i_Cab" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.000367" name="g_Cab" units="milliS_per_microF"/>
      <variable name="E_CaN" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <variable name="Cao" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Cab</ci>
            <apply>
               <times/>
               <ci>g_Cab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_CaN</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_CaN</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_concentration">
      <variable initial_value="14237.1" name="Nai" public_interface="out" units="micromolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Vmyo" public_interface="in" units="microlitre"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <variable name="Acap" public_interface="in" units="cm2"/>
      <variable name="i_Na" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Nab" public_interface="in" units="picoA_per_picoF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Nai</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>i_Na</ci>
                        <ci>i_Nab</ci>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaK</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaCa</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Acap</ci>
                  <ci>Cm</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Vmyo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current">
      <variable cmeta:id="fast_sodium_current_i_Na" name="i_Na" public_interface="out" units="picoA_per_picoF"/>
      <variable name="E_Na" public_interface="out" units="millivolt"/>
      <variable initial_value="13" name="g_Na" units="milliS_per_microF"/>
      <variable initial_value="0.713483e-6" name="O_Na" units="dimensionless"/>
      <variable initial_value="0.279132e-3" name="C_Na1" units="dimensionless"/>
      <variable initial_value="0.020752" name="C_Na2" units="dimensionless"/>
      <variable name="C_Na3" units="dimensionless"/>
      <variable initial_value="0.673345e-6" name="I1_Na" units="dimensionless"/>
      <variable initial_value="0.155787e-8" name="I2_Na" units="dimensionless"/>
      <variable initial_value="0.153176e-3" name="IF_Na" units="dimensionless"/>
      <variable initial_value="0.0113879" name="IC_Na2" units="dimensionless"/>
      <variable initial_value="0.34278" name="IC_Na3" units="dimensionless"/>
      <variable name="alpha_Na11" units="per_millisecond"/>
      <variable name="beta_Na11" units="per_millisecond"/>
      <variable name="alpha_Na12" units="per_millisecond"/>
      <variable name="beta_Na12" units="per_millisecond"/>
      <variable name="alpha_Na13" units="per_millisecond"/>
      <variable name="beta_Na13" units="per_millisecond"/>
      <variable name="alpha_Na3" units="per_millisecond"/>
      <variable name="beta_Na3" units="per_millisecond"/>
      <variable name="alpha_Na2" units="per_millisecond"/>
      <variable name="beta_Na2" units="per_millisecond"/>
      <variable name="alpha_Na4" units="per_millisecond"/>
      <variable name="beta_Na4" units="per_millisecond"/>
      <variable name="alpha_Na5" units="per_millisecond"/>
      <variable name="beta_Na5" units="per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Nao" public_interface="in" units="micromolar"/>
      <variable name="Nai" public_interface="in" units="micromolar"/>
      <variable name="Ko" public_interface="in" units="micromolar"/>
      <variable name="Ki" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na</ci>
            <apply>
               <times/>
               <ci>g_Na</ci>
               <ci>O_Na</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_Na</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
                           <ci>Nao</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                           <ci>Ko</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
                           <ci>Nai</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                           <ci>Ki</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C_Na3</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>O_Na</ci>
                  <ci>C_Na1</ci>
                  <ci>C_Na2</ci>
                  <ci>IF_Na</ci>
                  <ci>I1_Na</ci>
                  <ci>I2_Na</ci>
                  <ci>IC_Na2</ci>
                  <ci>IC_Na3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_Na2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_Na11</ci>
                     <ci>C_Na3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na12</ci>
                     <ci>C_Na1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na3</ci>
                     <ci>IC_Na2</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_Na11</ci>
                     <ci>C_Na2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na12</ci>
                     <ci>C_Na2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na3</ci>
                     <ci>C_Na2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_Na1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_Na12</ci>
                     <ci>C_Na2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na13</ci>
                     <ci>O_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na3</ci>
                     <ci>IF_Na</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_Na12</ci>
                     <ci>C_Na1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na13</ci>
                     <ci>C_Na1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na3</ci>
                     <ci>C_Na1</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O_Na</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_Na13</ci>
                     <ci>C_Na1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na2</ci>
                     <ci>IF_Na</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_Na13</ci>
                     <ci>O_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na2</ci>
                     <ci>O_Na</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>IF_Na</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_Na2</ci>
                     <ci>O_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na3</ci>
                     <ci>C_Na1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na4</ci>
                     <ci>I1_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na12</ci>
                     <ci>IC_Na2</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_Na2</ci>
                     <ci>IF_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na3</ci>
                     <ci>IF_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na4</ci>
                     <ci>IF_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na12</ci>
                     <ci>IF_Na</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I1_Na</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_Na4</ci>
                     <ci>IF_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na5</ci>
                     <ci>I2_Na</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_Na4</ci>
                     <ci>I1_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na5</ci>
                     <ci>I1_Na</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I2_Na</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_Na5</ci>
                  <ci>I1_Na</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_Na5</ci>
                  <ci>I2_Na</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>IC_Na2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_Na11</ci>
                     <ci>IC_Na3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na12</ci>
                     <ci>IF_Na</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na3</ci>
                     <ci>C_Na2</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_Na11</ci>
                     <ci>IC_Na2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na12</ci>
                     <ci>IC_Na2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na3</ci>
                     <ci>IC_Na2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>IC_Na3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_Na11</ci>
                     <ci>IC_Na2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_Na3</ci>
                     <ci>C_Na3</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_Na11</ci>
                     <ci>IC_Na3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_Na3</ci>
                     <ci>IC_Na3</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_Na11</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3.802</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_Na12</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3.802</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.23</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_Na13</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3.802</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_Na11</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.1917</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20.3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_Na12</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.2</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20.3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_Na13</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.22</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.5</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20.3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_Na3</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millisecond">7<sep/>-7</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.7</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_Na3</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0084</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.00002</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_Na2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.188495</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.6</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.393956</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_Na2</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>alpha_Na13</ci>
                  <ci>alpha_Na2</ci>
                  <ci>alpha_Na3</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_Na13</ci>
                  <ci>beta_Na3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_Na4</ci>
            <apply>
               <divide/>
               <ci>alpha_Na2</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_Na4</ci>
            <ci>alpha_Na3</ci>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_Na5</ci>
            <apply>
               <divide/>
               <ci>alpha_Na2</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">95000</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_Na5</ci>
            <apply>
               <divide/>
               <ci>alpha_Na3</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">50</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable cmeta:id="sodium_background_current_i_Nab" name="i_Nab" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.0026" name="g_Nab" units="milliS_per_microF"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Nab</ci>
            <apply>
               <times/>
               <ci>g_Nab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="potassium_concentration">
      <variable initial_value="143720" name="Ki" public_interface="out" units="micromolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Vmyo" public_interface="in" units="microlitre"/>
      <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
      <variable name="Acap" public_interface="in" units="cm2"/>
      <variable name="i_Kto_f" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kto_s" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_K1" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Ks" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kss" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kur" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_Kr" public_interface="in" units="picoA_per_picoF"/>
      <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ki</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>i_Kto_f</ci>
                           <ci>i_Kto_s</ci>
                           <ci>i_K1</ci>
                           <ci>i_Ks</ci>
                           <ci>i_Kss</ci>
                           <ci>i_Kur</ci>
                           <ci>i_Kr</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>i_NaK</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Acap</ci>
                  <ci>Cm</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>Vmyo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_transient_outward_potassium_current">
      <variable cmeta:id="fast_transient_outward_potassium_current_i_Kto_f" name="i_Kto_f" public_interface="out" units="picoA_per_picoF"/>
      <variable name="E_K" public_interface="out" units="millivolt"/>
      <variable initial_value="0.4067" name="g_Kto_f" units="milliS_per_microF"/>
      <variable initial_value="0.265563e-2" name="ato_f" units="dimensionless"/>
      <variable initial_value="0.999977" name="ito_f" units="dimensionless"/>
      <variable name="alpha_a" units="per_millisecond"/>
      <variable name="beta_a" units="per_millisecond"/>
      <variable name="alpha_i" units="per_millisecond"/>
      <variable name="beta_i" units="per_millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Ki" public_interface="in" units="micromolar"/>
      <variable name="Ko" public_interface="in" units="micromolar"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kto_f</ci>
            <apply>
               <times/>
               <ci>g_Kto_f</ci>
               <apply>
                  <power/>
                  <ci>ato_f</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>ito_f</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ato_f</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_a</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>ato_f</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_a</ci>
                  <ci>ato_f</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ito_f</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_i</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>ito_f</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_i</ci>
                  <ci>ito_f</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_a</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.18064</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_a</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.3956</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06237</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_i</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.000152</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0067083</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_i</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.00095</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.051335</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_transient_outward_potassium_current">
      <variable cmeta:id="slow_transient_outward_potassium_current_i_Kto_s" name="i_Kto_s" public_interface="out" units="picoA_per_picoF"/>
      <variable name="ass" public_interface="out" units="dimensionless"/>
      <variable name="iss" public_interface="out" units="dimensionless"/>
      <variable initial_value="0" name="g_Kto_s" units="milliS_per_microF"/>
      <variable initial_value="0.417069e-3" name="ato_s" units="dimensionless"/>
      <variable initial_value="0.998543" name="ito_s" units="dimensionless"/>
      <variable name="tau_ta_s" units="millisecond"/>
      <variable name="tau_ti_s" units="millisecond"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kto_s</ci>
            <apply>
               <times/>
               <ci>g_Kto_s</ci>
               <ci>ato_s</ci>
               <ci>ito_s</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ato_s</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ass</ci>
                  <ci>ato_s</ci>
               </apply>
               <ci>tau_ta_s</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ito_s</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>iss</ci>
                  <ci>ito_s</ci>
               </apply>
               <ci>tau_ti_s</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ass</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>iss</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.2</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ta_s</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.493</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0629</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2.058</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ti_s</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">270</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1050</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.2</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.7</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current">
      <variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="picoA_per_picoF"/>
      <variable name="Ko" public_interface="in" units="micromolar"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.2938</cn>
                        <ci>Ko</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">210</cn>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>V</ci>
                     <ci>E_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0896</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <ci>E_K</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current">
      <variable cmeta:id="slow_delayed_rectifier_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.00575" name="g_Ks" units="milliS_per_microF"/>
      <variable initial_value="0.262753e-3" name="nKs" units="dimensionless"/>
      <variable name="alpha_n" units="per_millisecond"/>
      <variable name="beta_n" units="per_millisecond"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <apply>
                  <power/>
                  <ci>nKs</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>nKs</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_n</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>nKs</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_n</ci>
                  <ci>nKs</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_n</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.00000481333</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.128</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_n</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0000953333</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.038</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ultra_rapidly_activating_delayed_rectifier_potassium_current">
      <variable cmeta:id="ultra_rapidly_activating_delayed_rectifier_potassium_current_i_Kur" name="i_Kur" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.16" name="g_Kur" units="milliS_per_microF"/>
      <variable initial_value="0.417069e-3" name="aur" units="dimensionless"/>
      <variable initial_value="0.998543" name="iur" units="dimensionless"/>
      <variable name="tau_aur" units="millisecond"/>
      <variable name="tau_iur" units="millisecond"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="ass" public_interface="in" units="dimensionless"/>
      <variable name="iss" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kur</ci>
            <apply>
               <times/>
               <ci>g_Kur</ci>
               <ci>aur</ci>
               <ci>iur</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>aur</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ass</ci>
                  <ci>aur</ci>
               </apply>
               <ci>tau_aur</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>iur</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>iss</ci>
                  <ci>iur</ci>
               </apply>
               <ci>tau_iur</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_aur</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.493</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0629</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2.058</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_iur</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1200</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">170</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.2</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.7</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="non_inactivating_steady_state_potassium_current">
      <variable cmeta:id="non_inactivating_steady_state_potassium_current_i_Kss" name="i_Kss" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.05" name="g_Kss" units="milliS_per_microF"/>
      <variable initial_value="0.417069e-3" name="aKss" units="dimensionless"/>
      <variable initial_value="1" name="iKss" units="dimensionless"/>
      <variable name="tau_Kss" units="millisecond"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="ass" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kss</ci>
            <apply>
               <times/>
               <ci>g_Kss</ci>
               <ci>aKss</ci>
               <ci>iKss</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>aKss</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ass</ci>
                  <ci>aKss</ci>
               </apply>
               <ci>tau_Kss</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>iKss</ci>
            </apply>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
         </apply>
         <apply>
            <eq/>
            <ci>tau_Kss</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">39.3</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0862</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">13.17</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current">
      <variable cmeta:id="rapid_delayed_rectifier_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.078" name="g_Kr" units="milliS_per_microF"/>
      <variable initial_value="0.175298e-3" name="O_K" units="dimensionless"/>
      <variable initial_value="0.992513e-3" name="C_K1" units="dimensionless"/>
      <variable initial_value="0.641229e-3" name="C_K2" units="dimensionless"/>
      <variable name="C_K0" units="dimensionless"/>
      <variable initial_value="0.319129e-4" name="I_K" units="dimensionless"/>
      <variable name="alpha_a0" units="per_millisecond"/>
      <variable name="beta_a0" units="per_millisecond"/>
      <variable initial_value="0.036778" name="kb" units="per_millisecond"/>
      <variable initial_value="0.023761" name="kf" units="per_millisecond"/>
      <variable name="alpha_a1" units="per_millisecond"/>
      <variable name="beta_a1" units="per_millisecond"/>
      <variable name="alpha_i" units="per_millisecond"/>
      <variable name="beta_i" units="per_millisecond"/>
      <variable name="time" public_interface="in" units="millisecond"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Nao" public_interface="in" units="micromolar"/>
      <variable name="Nai" public_interface="in" units="micromolar"/>
      <variable name="Ko" public_interface="in" units="micromolar"/>
      <variable name="Ki" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <ci>O_K</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <ln/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.98</cn>
                                 <ci>Ko</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
                                 <ci>Nao</ci>
                              </apply>
                           </apply>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.98</cn>
                                 <ci>Ki</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
                                 <ci>Nai</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C_K0</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>C_K1</ci>
                  <ci>C_K2</ci>
                  <ci>O_K</ci>
                  <ci>I_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_K2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>kf</ci>
                     <ci>C_K1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_a1</ci>
                     <ci>O_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>kb</ci>
                     <ci>C_K2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_a1</ci>
                     <ci>C_K2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_K1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_a0</ci>
                     <ci>C_K0</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kb</ci>
                     <ci>C_K2</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_a0</ci>
                     <ci>C_K1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>kf</ci>
                     <ci>C_K1</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O_K</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_a1</ci>
                     <ci>C_K2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>beta_i</ci>
                     <ci>I_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_a1</ci>
                     <ci>O_K</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>alpha_i</ci>
                     <ci>O_K</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>I_K</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_i</ci>
                  <ci>O_K</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_i</ci>
                  <ci>I_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_a0</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.022348</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01176</cn>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_a0</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.047002</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0631</cn>
                     </apply>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_a1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.013733</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.038198</cn>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_a1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0000689</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04178</cn>
                     </apply>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_i</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.090821</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.023391</cn>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_i</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.006497</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03268</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump_current">
      <variable cmeta:id="sodium_potassium_pump_current_i_NaK" name="i_NaK" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="0.88" name="i_NaK_max" units="picoA_per_picoF"/>
      <variable initial_value="21000" name="Km_Nai" units="micromolar"/>
      <variable initial_value="1500" name="Km_Ko" units="micromolar"/>
      <variable name="f_NaK" units="dimensionless"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Nai" public_interface="in" units="micromolar"/>
      <variable name="Nao" public_interface="in" units="micromolar"/>
      <variable name="Ko" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>i_NaK_max</ci>
                        <ci>f_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Km_Nai</ci>
                              <ci>Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Ko</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>Km_Ko</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">67300</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_activated_chloride_current">
      <variable cmeta:id="calcium_activated_chloride_current_i_ClCa" name="i_ClCa" public_interface="out" units="picoA_per_picoF"/>
      <variable initial_value="10" name="g_ClCa" units="milliS_per_microF"/>
      <variable name="O_ClCa" units="dimensionless"/>
      <variable initial_value="-40" name="E_Cl" units="millivolt"/>
      <variable initial_value="10" name="Km_Cl" units="micromolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Cai" public_interface="in" units="micromolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_ClCa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>g_ClCa</ci>
                     <ci>O_ClCa</ci>
                     <ci>Cai</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>Cai</ci>
                     <ci>Km_Cl</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Cl</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>O_ClCa</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">46.7</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.8</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
  
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_concentration" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_fluxes" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_buffering" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ryanodine_receptors" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_calcium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_concentration" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="potassium_concentration" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_transient_outward_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_transient_outward_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ultra_rapidly_activating_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="non_inactivating_steady_state_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="L_type_calcium_current"/>
      <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_pump_current"/>
      <map_variables variable_1="i_pCa" variable_2="i_pCa"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_calcium_exchange_current"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_background_current"/>
      <map_variables variable_1="i_Cab" variable_2="i_Cab"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="fast_sodium_current"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_background_current"/>
      <map_variables variable_1="i_Nab" variable_2="i_Nab"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_potassium_pump_current"/>
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