Emergent properties of networks of biological signaling pathways
Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This particular version of the CellML model describes the PLA2 pathway component of the Bhalla-Iyengar model. This model is unsuitable constrained and can not be solved. ValidateCellML verifies this model as valid CellML but detects unit inconsistencies.
Model Structure
ABSTRACT: Many distinct signaling pathways allow the cell to receive, process, and respond to information. Often, components of different pathways interact, resulting in signaling networks. Biochemical signaling networks were constructed with experimentally obtained constants and analyzed by computational methods to understand their role in complex biological processes. These networks exhibit emergent properties such as integration of signals across multiple time scales, generation of distinct outputs depending on input strength and duration, and self-sustaining feedback loops. Feedback can result in bistable behavior with discrete steady-state activities, well-defined input thresholds for transition between states and prolonged signal output, and signal modulation in response to transient stimuli. These properties of signaling networks raise the possibility that information for "learned behavior" of biological systems may be stored within intracellular biochemical reactions that comprise signaling pathways.
The original paper reference is cited below:
Emergent properties of networks of biological signaling pathways. Bhalla US, Iyengar R.
Science 1999 Jan 15; 283(5400); 381-7. PubMed ID: 9888852
model diagram
A rendering of the PLA2 pathway component of the Bhalla-Iyengar model.
Science
PLA2 pathway component of the Bhalla-Iyengar model
Matthew
McCormick
m.mccormick@auckland.ac.nz
2007-08-28T00:00:00+00:00
1999-01-15
Emergent Properties of Networks of Biological Signaling Pathways
283
381
387
James
Lawson
Richard
keyword
signal_transduction
The University of Auckland
Auckland Bioengineering Institute
updated curation status
99105994
2009-05-27T15:06:30+12:00
Upinder
Bhalla
S
Ravi
Iyengar