- Author:
- schdemp <sdem348@aucklanduni.ac.nz>
- Date:
- 2022-06-16 18:11:58-04:00
- Desc:
- Change parameter file names and subsequent loading name strings
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/8a2/rawfile/6c4ba7884bad10ef792565cfc3d30eb9fec6748c/sten2020_neuron_pyramidal.cellml
<?xml version='1.0'?>
<model name="pyramidal_neuron" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<!-- import units-->
<import xlink:href="sten2020_units.cellml">
<units name="Hz" units_ref="Hz"/>
</import>
<!-- define pyramidal pathway-->
<component name="pyramidal">
<!--import coefficients-->
<variable name="t" public_interface="in" units="second"/>
<variable name="N_Pyr" public_interface="in" units="dimensionless"/>
<variable name="k_Ca" public_interface="in" units="per_sec"/>
<variable name="sink_Ca_Pyr" public_interface="in" units="per_sec"/>
<variable name="k_PL" public_interface="in" units="per_sec"/>
<variable name="k_COX" public_interface="in" units="per_sec"/>
<variable name="k_PGE2" public_interface="in" units="per_sec"/>
<variable name="sink_PGE2" public_interface="in" units="per_sec"/>
<variable name="initCA_Pyr" public_interface="in" units="dimensionless"/>
<variable name="initAA" public_interface="in" units="dimensionless"/>
<variable name="initPGE2" public_interface="in" units="dimensionless"/>
<variable name="initPGE2_vsm" public_interface="in" units="dimensionless"/>
<!--set steady state initial value-->
<variable initial_value="initCA_Pyr" name="Ca_Pyr" public_interface="out" units="dimensionless"/>
<variable initial_value="initAA" name="AA" public_interface="out" units="dimensionless"/>
<variable initial_value="initPGE2" name="PGE_2" public_interface="out" units="dimensionless"/>
<variable initial_value="initPGE2_vsm" name="PGE_2vsm" public_interface="out" units="dimensionless"/>
<!--set ode's-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>Ca_Pyr</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_Ca</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>N_Pyr</ci>
</apply>
</apply>
<apply>
<times/>
<ci>sink_Ca_Pyr</ci>
<ci>Ca_Pyr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>AA</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_PL</ci>
<ci>Ca_Pyr</ci>
</apply>
<apply>
<times/>
<ci>k_COX</ci>
<ci>AA</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>PGE_2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_COX</ci>
<ci>AA</ci>
</apply>
<apply>
<times/>
<ci>k_PGE2</ci>
<ci>PGE_2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>PGE_2vsm</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_PGE2</ci>
<ci>PGE_2</ci>
</apply>
<apply>
<times/>
<ci>sink_PGE2</ci>
<ci>PGE_2vsm</ci>
</apply>
</apply>
</apply>
</math>
</component>
</model>
