- Author:
- Shelley Fong <s.fong@auckland.ac.nz>
- Date:
- 2022-05-02 13:25:40+12:00
- Desc:
- delete sentence
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/848/rawfile/98c2d94ee9d4dbdfcd74f4bc2dde0c8eeb9e61a5/bhalla_kinetic.cellml
<?xml version='1.0' encoding='UTF-8'?>
<!-- FILE : bi_PLC_beta_pathway_1999.xml-->
<model cmeta:id="bhalla_model_1999" name="bhalla_model_1999" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="micromolar">
<unit prefix="micro" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="flux">
<unit units="micromolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="first_order_rate_constant_units">
<unit exponent="-1" units="second"/>
</units>
<units name="second_order_rate_constant_units">
<unit exponent="-1" units="micromolar"/>
<unit exponent="-1" units="second"/>
</units>
<component name="global_variables">
<variable name="time" public_interface="out" units="second"/>
</component>
<component cmeta:id="DAG" name="DAG">
<variable initial_value="0" name="DAG" public_interface="out" units="micromolar"/>
<variable name="delta_DAG_rxn2" public_interface="in" units="flux"/>
<variable name="delta_DAG_rxn3" public_interface="in" units="flux"/>
<variable name="delta_DAG_rxn0" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>DAG</ci>
</apply>
<apply>
<plus/>
<ci>delta_DAG_rxn2</ci>
<ci>delta_DAG_rxn3</ci>
<ci>delta_DAG_rxn0</ci>
</apply>
</apply>
</math>
</component>
<component name="PC">
<variable initial_value="0" name="PC" public_interface="out" units="micromolar"/>
<variable name="delta_PC_rxn0" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PC</ci>
</apply>
<ci>delta_PC_rxn0</ci>
</apply>
</math>
</component>
<component cmeta:id="IP3" name="IP3">
<variable initial_value="0" name="IP3" public_interface="out" units="micromolar"/>
<variable name="delta_IP3_rxn2" public_interface="in" units="flux"/>
<variable name="delta_IP3_rxn3" public_interface="in" units="flux"/>
<variable name="delta_IP3_rxn1" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IP3</ci>
</apply>
<apply>
<plus/>
<ci>delta_IP3_rxn2</ci>
<ci>delta_IP3_rxn3</ci>
<ci>delta_IP3_rxn1</ci>
</apply>
</apply>
</math>
</component>
<component name="Inositol">
<variable initial_value="0" name="Inositol" public_interface="out" units="micromolar"/>
<variable name="delta_Inositol_rxn1" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Inositol</ci>
</apply>
<ci>delta_Inositol_rxn1</ci>
</apply>
</math>
</component>
<component cmeta:id="PLC" name="PLC">
<variable initial_value="0.8" name="PLC" public_interface="out" units="micromolar"/>
<variable name="delta_PLC_rxn4" public_interface="in" units="flux"/>
<variable name="delta_PLC_rxn5" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PLC</ci>
</apply>
<apply>
<plus/>
<ci>delta_PLC_rxn4</ci>
<ci>delta_PLC_rxn5</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="Ca" name="Ca">
<variable initial_value="1.0" name="Ca" public_interface="out" units="micromolar"/>
<variable name="delta_Ca_rxn4" public_interface="in" units="flux"/>
<variable name="delta_Ca_rxn6" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca</ci>
</apply>
<apply>
<plus/>
<ci>delta_Ca_rxn4</ci>
<ci>delta_Ca_rxn6</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_PLC">
<variable initial_value="0" name="Ca_PLC" public_interface="out" units="micromolar"/>
<variable name="delta_Ca_PLC_rxn4" public_interface="in" units="flux"/>
<variable name="delta_Ca_PLC_rxn8" public_interface="in" units="flux"/>
<variable name="delta_Ca_PLC_rxn7" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_PLC</ci>
</apply>
<apply>
<plus/>
<ci>delta_Ca_PLC_rxn4</ci>
<ci>delta_Ca_PLC_rxn8</ci>
<ci>delta_Ca_PLC_rxn7</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="PIP2" name="PIP2">
<variable initial_value="10.0" name="PIP2" public_interface="out" units="micromolar"/>
<variable name="delta_PIP2_rxn2" public_interface="in" units="flux"/>
<variable name="delta_PIP2_rxn3" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PIP2</ci>
</apply>
<apply>
<plus/>
<ci>delta_PIP2_rxn2</ci>
<ci>delta_PIP2_rxn3</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="Gq" name="Gq">
<variable initial_value="1.0" name="Gq" public_interface="out" units="micromolar"/>
<variable name="delta_Gq_rxn5" public_interface="in" units="flux"/>
<variable name="delta_Gq_rxn7" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gq</ci>
</apply>
<apply>
<plus/>
<ci>delta_Gq_rxn5</ci>
<ci>delta_Gq_rxn7</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="G_GDP" name="G_GDP">
<variable initial_value="0" name="G_GDP" public_interface="out" units="micromolar"/>
<variable name="delta_GGDP_rxn8" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>G_GDP</ci>
</apply>
<ci>delta_GGDP_rxn8</ci>
</apply>
</math>
</component>
<component name="Gq_PLC">
<variable initial_value="0" name="Gq_PLC" public_interface="out" units="micromolar"/>
<variable name="delta_Gq_PLC_rxn5" public_interface="in" units="flux"/>
<variable name="delta_Gq_PLC_rxn6" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Gq_PLC</ci>
</apply>
<apply>
<plus/>
<ci>delta_Gq_PLC_rxn5</ci>
<ci>delta_Gq_PLC_rxn6</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_Gq_PLC">
<variable initial_value="1.0" name="Ca_Gq_PLC" public_interface="out" units="micromolar"/>
<variable name="delta_Ca_Gq_PLC_rxn6" public_interface="in" units="flux"/>
<variable name="delta_Ca_Gq_PLC_rxn7" public_interface="in" units="flux"/>
<variable name="delta_Ca_Gq_PLC_rxn8" public_interface="in" units="flux"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Gq_PLC</ci>
</apply>
<apply>
<plus/>
<ci>delta_Ca_Gq_PLC_rxn6</ci>
<ci>delta_Ca_Gq_PLC_rxn7</ci>
<ci>delta_Ca_Gq_PLC_rxn8</ci>
</apply>
</apply>
</math>
</component>
<component name="reaction0">
<variable name="DAG" public_interface="in" units="micromolar"/>
<variable name="PC" public_interface="in" units="micromolar"/>
<variable name="delta_DAG_rxn0" public_interface="out" units="flux"/>
<variable name="delta_PC_rxn0" public_interface="out" units="flux"/>
<variable initial_value="0.15" name="k0" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="no">-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k0</ci>
<ci>DAG</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_DAG_rxn0</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_PC_rxn0</ci>
<ci>rate</ci>
</apply>
</math>
</component>
<component name="reaction1">
<variable name="IP3" public_interface="in" units="micromolar"/>
<variable name="Inositol" public_interface="in" units="micromolar"/>
<variable name="delta_IP3_rxn1" public_interface="out" units="flux"/>
<variable name="delta_Inositol_rxn1" public_interface="out" units="flux"/>
<variable initial_value="2.5" name="k1" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="no"> -->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k1</ci>
<ci>IP3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_IP3_rxn1</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Inositol_rxn1</ci>
<ci>rate</ci>
</apply>
</math>
</component>
<component name="reaction2">
<variable name="PIP2" public_interface="in" units="micromolar"/>
<variable name="DAG" public_interface="in" units="micromolar"/>
<variable name="IP3" public_interface="in" units="micromolar"/>
<variable name="Ca_PLC" public_interface="in" units="micromolar"/>
<variable name="delta_PIP2_rxn2" public_interface="out" units="flux"/>
<variable name="delta_DAG_rxn2" public_interface="out" units="flux"/>
<variable name="delta_IP3_rxn2" public_interface="out" units="flux"/>
<variable initial_value="5.0" name="km2" units="micromolar"/>
<variable initial_value="48.0" name="vmax2" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="no"> -->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>PIP2</ci>
<ci>vmax2</ci>
</apply>
<apply>
<plus/>
<ci>km2</ci>
<ci>PIP2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_PIP2_rxn2</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_IP3_rxn2</ci>
<ci>rate</ci>
</apply>
<apply>
<eq/>
<ci>delta_DAG_rxn2</ci>
<ci>rate</ci>
</apply>
</math>
<!-- Ca_PLC = rate - rate; // catalyst-->
</component>
<component name="reaction3">
<variable name="PIP2" public_interface="in" units="micromolar"/>
<variable name="DAG" public_interface="in" units="micromolar"/>
<variable name="IP3" public_interface="in" units="micromolar"/>
<variable name="Ca_Gq_PLC" public_interface="in" units="micromolar"/>
<variable name="delta_PIP2_rxn3" public_interface="out" units="flux"/>
<variable name="delta_DAG_rxn3" public_interface="out" units="flux"/>
<variable name="delta_IP3_rxn3" public_interface="out" units="flux"/>
<variable initial_value="19.84166667" name="km3" units="micromolar"/>
<variable initial_value="10.0" name="vmax3" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="no">-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>PIP2</ci>
<ci>vmax3</ci>
</apply>
<apply>
<plus/>
<ci>km3</ci>
<ci>PIP2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_PIP2_rxn3</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_DAG_rxn3</ci>
<ci>rate</ci>
</apply>
<apply>
<eq/>
<ci>delta_IP3_rxn3</ci>
<ci>rate</ci>
</apply>
</math>
<!-- Ca_Gq_PLC = rate - rate; // catalyst-->
</component>
<component name="reaction4">
<variable name="PLC" public_interface="in" units="micromolar"/>
<variable name="Ca" public_interface="in" units="micromolar"/>
<variable name="Ca_PLC" public_interface="in" units="micromolar"/>
<variable name="delta_PLC_rxn4" public_interface="out" units="flux"/>
<variable name="delta_Ca_rxn4" public_interface="out" units="flux"/>
<variable name="delta_Ca_PLC_rxn4" public_interface="out" units="flux"/>
<variable initial_value="0.000005" name="k4p" units="second_order_rate_constant_units"/>
<variable initial_value="1.0" name="k4m" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="yes">-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k4p</ci>
<ci>PLC</ci>
<ci>Ca</ci>
</apply>
<apply>
<times/>
<ci>k4m</ci>
<ci>Ca_PLC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_PLC_rxn4</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Ca_rxn4</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Ca_PLC_rxn4</ci>
<ci>rate</ci>
</apply>
</math>
</component>
<component name="reaction5">
<variable name="PLC" public_interface="in" units="micromolar"/>
<variable name="Gq" public_interface="in" units="micromolar"/>
<variable name="Gq_PLC" public_interface="in" units="micromolar"/>
<variable name="delta_PLC_rxn5" public_interface="out" units="flux"/>
<variable name="delta_Gq_rxn5" public_interface="out" units="flux"/>
<variable name="delta_Gq_PLC_rxn5" public_interface="out" units="flux"/>
<variable initial_value="0.0000042" name="k5p" units="second_order_rate_constant_units"/>
<variable initial_value="1.0" name="k5m" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="yes">-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k5p</ci>
<ci>PLC</ci>
<ci>Gq</ci>
</apply>
<apply>
<times/>
<ci>k5m</ci>
<ci>Gq_PLC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_PLC_rxn5</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Gq_rxn5</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Gq_PLC_rxn5</ci>
<ci>rate</ci>
</apply>
</math>
</component>
<component name="reaction6">
<variable name="Ca" public_interface="in" units="micromolar"/>
<variable name="Gq_PLC" public_interface="in" units="micromolar"/>
<variable name="Ca_Gq_PLC" public_interface="in" units="micromolar"/>
<variable name="delta_Ca_rxn6" public_interface="out" units="flux"/>
<variable name="delta_Gq_PLC_rxn6" public_interface="out" units="flux"/>
<variable name="delta_Ca_Gq_PLC_rxn6" public_interface="out" units="flux"/>
<variable initial_value="0.00005" name="k6p" units="second_order_rate_constant_units"/>
<variable initial_value="1.0" name="k6m" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="yes">-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k6p</ci>
<ci>Ca</ci>
<ci>Gq_PLC</ci>
</apply>
<apply>
<times/>
<ci>k6m</ci>
<ci>Ca_Gq_PLC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Ca_rxn6</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Gq_PLC_rxn6</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Ca_Gq_PLC_rxn6</ci>
<ci>rate</ci>
</apply>
</math>
</component>
<component name="reaction7">
<variable name="Ca_PLC" public_interface="in" units="micromolar"/>
<variable name="Gq" public_interface="in" units="micromolar"/>
<variable name="Ca_Gq_PLC" public_interface="in" units="micromolar"/>
<variable name="delta_Ca_PLC_rxn7" public_interface="out" units="flux"/>
<variable name="delta_Gq_rxn7" public_interface="out" units="flux"/>
<variable name="delta_Ca_Gq_PLC_rxn7" public_interface="out" units="flux"/>
<variable initial_value="0.000042" name="k7p" units="second_order_rate_constant_units"/>
<variable initial_value="1.0" name="k7m" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="yes">-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k7p</ci>
<ci>Ca_PLC</ci>
<ci>Gq</ci>
</apply>
<apply>
<times/>
<ci>k7m</ci>
<ci>Ca_Gq_PLC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Ca_PLC_rxn7</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Gq_rxn7</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Ca_Gq_PLC_rxn7</ci>
<ci>rate</ci>
</apply>
</math>
</component>
<component name="reaction8">
<variable name="Ca_Gq_PLC" public_interface="in" units="micromolar"/>
<variable name="Ca_PLC" public_interface="in" units="micromolar"/>
<variable name="G_GDP" public_interface="in" units="micromolar"/>
<variable name="delta_Ca_Gq_PLC_rxn8" public_interface="out" units="flux"/>
<variable name="delta_Ca_PLC_rxn8" public_interface="out" units="flux"/>
<variable name="delta_GGDP_rxn8" public_interface="out" units="flux"/>
<variable initial_value="0.0133" name="k8" units="first_order_rate_constant_units"/>
<variable name="rate" units="flux"/>
<!-- <reaction reversible="no">-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>rate</ci>
<apply>
<times/>
<ci>k8</ci>
<ci>Ca_Gq_PLC</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Ca_Gq_PLC_rxn8</ci>
<apply>
<minus/>
<ci>rate</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_Ca_PLC_rxn8</ci>
<ci>rate</ci>
</apply>
<apply>
<eq/>
<ci>delta_GGDP_rxn8</ci>
<ci>rate</ci>
</apply>
</math>
</component>
<connection>
<map_components component_1="DAG" component_2="reaction2"/>
<map_variables variable_1="DAG" variable_2="DAG"/>
<map_variables variable_1="delta_DAG_rxn2" variable_2="delta_DAG_rxn2"/>
</connection>
<connection>
<map_components component_1="DAG" component_2="reaction3"/>
<map_variables variable_1="DAG" variable_2="DAG"/>
<map_variables variable_1="delta_DAG_rxn3" variable_2="delta_DAG_rxn3"/>
</connection>
<connection>
<map_components component_1="DAG" component_2="reaction0"/>
<map_variables variable_1="DAG" variable_2="DAG"/>
<map_variables variable_1="delta_DAG_rxn0" variable_2="delta_DAG_rxn0"/>
</connection>
<connection>
<map_components component_1="PC" component_2="reaction0"/>
<map_variables variable_1="PC" variable_2="PC"/>
<map_variables variable_1="delta_PC_rxn0" variable_2="delta_PC_rxn0"/>
</connection>
<connection>
<map_components component_1="IP3" component_2="reaction2"/>
<map_variables variable_1="IP3" variable_2="IP3"/>
<map_variables variable_1="delta_IP3_rxn2" variable_2="delta_IP3_rxn2"/>
</connection>
<connection>
<map_components component_1="IP3" component_2="reaction3"/>
<map_variables variable_1="IP3" variable_2="IP3"/>
<map_variables variable_1="delta_IP3_rxn3" variable_2="delta_IP3_rxn3"/>
</connection>
<connection>
<map_components component_1="IP3" component_2="reaction1"/>
<map_variables variable_1="IP3" variable_2="IP3"/>
<map_variables variable_1="delta_IP3_rxn1" variable_2="delta_IP3_rxn1"/>
</connection>
<connection>
<map_components component_1="Inositol" component_2="reaction1"/>
<map_variables variable_1="Inositol" variable_2="Inositol"/>
<map_variables variable_1="delta_Inositol_rxn1" variable_2="delta_Inositol_rxn1"/>
</connection>
<connection>
<map_components component_1="PLC" component_2="reaction4"/>
<map_variables variable_1="PLC" variable_2="PLC"/>
<map_variables variable_1="delta_PLC_rxn4" variable_2="delta_PLC_rxn4"/>
</connection>
<connection>
<map_components component_1="PLC" component_2="reaction5"/>
<map_variables variable_1="PLC" variable_2="PLC"/>
<map_variables variable_1="delta_PLC_rxn5" variable_2="delta_PLC_rxn5"/>
</connection>
<connection>
<map_components component_1="Ca" component_2="reaction4"/>
<map_variables variable_1="Ca" variable_2="Ca"/>
<map_variables variable_1="delta_Ca_rxn4" variable_2="delta_Ca_rxn4"/>
</connection>
<connection>
<map_components component_1="Ca_PLC" component_2="reaction4"/>
<map_variables variable_1="Ca_PLC" variable_2="Ca_PLC"/>
<map_variables variable_1="delta_Ca_PLC_rxn4" variable_2="delta_Ca_PLC_rxn4"/>
</connection>
<connection>
<map_components component_1="Ca_PLC" component_2="reaction8"/>
<map_variables variable_1="Ca_PLC" variable_2="Ca_PLC"/>
<map_variables variable_1="delta_Ca_PLC_rxn8" variable_2="delta_Ca_PLC_rxn8"/>
</connection>
<connection>
<map_components component_1="Ca_PLC" component_2="reaction7"/>
<map_variables variable_1="Ca_PLC" variable_2="Ca_PLC"/>
<map_variables variable_1="delta_Ca_PLC_rxn7" variable_2="delta_Ca_PLC_rxn7"/>
</connection>
<connection>
<map_components component_1="Ca_PLC" component_2="reaction2"/>
<map_variables variable_1="Ca_PLC" variable_2="Ca_PLC"/>
</connection>
<connection>
<map_components component_1="PIP2" component_2="reaction2"/>
<map_variables variable_1="PIP2" variable_2="PIP2"/>
<map_variables variable_1="delta_PIP2_rxn2" variable_2="delta_PIP2_rxn2"/>
</connection>
<connection>
<map_components component_1="PIP2" component_2="reaction3"/>
<map_variables variable_1="PIP2" variable_2="PIP2"/>
<map_variables variable_1="delta_PIP2_rxn3" variable_2="delta_PIP2_rxn3"/>
</connection>
<connection>
<map_components component_1="G_GDP" component_2="reaction8"/>
<map_variables variable_1="G_GDP" variable_2="G_GDP"/>
<map_variables variable_1="delta_GGDP_rxn8" variable_2="delta_GGDP_rxn8"/>
</connection>
<connection>
<map_components component_1="Gq" component_2="reaction5"/>
<map_variables variable_1="Gq" variable_2="Gq"/>
<map_variables variable_1="delta_Gq_rxn5" variable_2="delta_Gq_rxn5"/>
</connection>
<connection>
<map_components component_1="Ca" component_2="reaction6"/>
<map_variables variable_1="Ca" variable_2="Ca"/>
<map_variables variable_1="delta_Ca_rxn6" variable_2="delta_Ca_rxn6"/>
</connection>
<connection>
<map_components component_1="Gq" component_2="reaction7"/>
<map_variables variable_1="Gq" variable_2="Gq"/>
<map_variables variable_1="delta_Gq_rxn7" variable_2="delta_Gq_rxn7"/>
</connection>
<connection>
<map_components component_1="Gq_PLC" component_2="reaction5"/>
<map_variables variable_1="Gq_PLC" variable_2="Gq_PLC"/>
<map_variables variable_1="delta_Gq_PLC_rxn5" variable_2="delta_Gq_PLC_rxn5"/>
</connection>
<connection>
<map_components component_1="Gq_PLC" component_2="reaction6"/>
<map_variables variable_1="Gq_PLC" variable_2="Gq_PLC"/>
<map_variables variable_1="delta_Gq_PLC_rxn6" variable_2="delta_Gq_PLC_rxn6"/>
</connection>
<connection>
<map_components component_1="Ca_Gq_PLC" component_2="reaction6"/>
<map_variables variable_1="Ca_Gq_PLC" variable_2="Ca_Gq_PLC"/>
<map_variables variable_1="delta_Ca_Gq_PLC_rxn6" variable_2="delta_Ca_Gq_PLC_rxn6"/>
</connection>
<connection>
<map_components component_1="Ca_Gq_PLC" component_2="reaction7"/>
<map_variables variable_1="Ca_Gq_PLC" variable_2="Ca_Gq_PLC"/>
<map_variables variable_1="delta_Ca_Gq_PLC_rxn7" variable_2="delta_Ca_Gq_PLC_rxn7"/>
</connection>
<connection>
<map_components component_1="Ca_Gq_PLC" component_2="reaction8"/>
<map_variables variable_1="Ca_Gq_PLC" variable_2="Ca_Gq_PLC"/>
<map_variables variable_1="delta_Ca_Gq_PLC_rxn8" variable_2="delta_Ca_Gq_PLC_rxn8"/>
</connection>
<connection>
<map_components component_1="Ca_Gq_PLC" component_2="reaction3"/>
<map_variables variable_1="Ca_Gq_PLC" variable_2="Ca_Gq_PLC"/>
</connection>
<connection>
<map_components component_1="DAG" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="PC" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="IP3" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Inositol" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="PLC" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_PLC" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="PIP2" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Gq" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Gq_PLC" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="G_GDP" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_Gq_PLC" component_2="global_variables"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<documentation xmlns="http://cellml.org/tmp-documentation">
<article xmlns="http://cellml.org/tmp-documentation">
<articleinfo xmlns="http://cellml.org/tmp-documentation">
<title xmlns="http://cellml.org/tmp-documentation">The Phospholipase C (PLC) (beta) Pathway Model from Bhalla and Iyengar</title>
<author xmlns="http://cellml.org/tmp-documentation">
<firstname xmlns="http://cellml.org/tmp-documentation">Catherine</firstname>
<surname xmlns="http://cellml.org/tmp-documentation">Lloyd</surname>
<affiliation xmlns="http://cellml.org/tmp-documentation">
<shortaffil xmlns="http://cellml.org/tmp-documentation">Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section xmlns="http://cellml.org/tmp-documentation" id="sec_status">
<title xmlns="http://cellml.org/tmp-documentation">Model Status</title>
<para xmlns="http://cellml.org/tmp-documentation">
This version of the CellML model describes the PLC (beta) pathway component of the Bhalla-Iyengar model. This model is able to be solved but does not give the correct results as it is not connected to the other modules of the pathway. ValidateCellML verifies this model as valid CellML but detects unit inconsistencies.
</para>
</section>
<sect1 xmlns="http://cellml.org/tmp-documentation" id="sec_structure">
<title xmlns="http://cellml.org/tmp-documentation">Model Structure</title>
<para xmlns="http://cellml.org/tmp-documentation">
ABSTRACT: Many distinct signaling pathways allow the cell to receive, process, and respond to information. Often, components of different pathways interact, resulting in signaling networks. Biochemical signaling networks were constructed with experimentally obtained constants and analyzed by computational methods to understand their role in complex biological processes. These networks exhibit emergent properties such as integration of signals across multiple time scales, generation of distinct outputs depending on input strength and duration, and self-sustaining feedback loops. Feedback can result in bistable behavior with discrete steady-state activities, well-defined input thresholds for transition between states and prolonged signal output, and signal modulation in response to transient stimuli. These properties of signaling networks raise the possibility that information for "learned behavior" of biological systems may be stored within intracellular biochemical reactions that comprise signaling pathways.
</para>
<para xmlns="http://cellml.org/tmp-documentation">
The original paper reference is cited below:
</para>
<para xmlns="http://cellml.org/tmp-documentation">
Emergent properties of networks of biological signaling pathways. Bhalla US, Iyengar R.
<emphasis xmlns="http://cellml.org/tmp-documentation">Science</emphasis> 1999 Jan 15; 283(5400); 381-7. <ulink xmlns="http://cellml.org/tmp-documentation" url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9888852&dopt=Abstract">PubMed ID: 9888852</ulink>
</para>
<informalfigure xmlns="http://cellml.org/tmp-documentation" float="0" id="fig_pathway_diagram">
<mediaobject xmlns="http://cellml.org/tmp-documentation">
<imageobject xmlns="http://cellml.org/tmp-documentation">
<objectinfo xmlns="http://cellml.org/tmp-documentation">
<title xmlns="http://cellml.org/tmp-documentation">model diagram</title>
</objectinfo>
<imagedata xmlns="http://cellml.org/tmp-documentation" fileref="bhalla_iyengar_PLC_beta_1999.png"/>
</imageobject>
</mediaobject>
<caption xmlns="http://cellml.org/tmp-documentation">A rendering of the PLC (beta) pathway component of the Bhalla-Iyengar model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Seq xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d4a1e3e8-bdd2-4778-8711-9c1bd349f333">
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="rdf:#52613714-6246-4707-b530-70ae91b6d008"/>
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="rdf:#05904991-198d-432e-8aad-a676859a6636"/>
</rdf:Seq>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6da822a7-f1bf-4867-b3df-bbcbb332fc29">
<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">signal transduction</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#38257523-7d04-4bed-bfe3-d047d90a0b6c">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2001-11-06</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0c4612e9-8ffe-4ee3-bd16-cda5968105bf">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">phospholipase C (PLC) pathway component of the Bhalla-Iyengar model</dc:title>
<dc:publisher xmlns:dc="http://purl.org/dc/elements/1.1/">
The University of Auckland, Auckland Bioengineering Institute
</dc:publisher>
<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#38257523-7d04-4bed-bfe3-d047d90a0b6c" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#49b060ed-78c7-46e6-b876-5c6aa2c53f76" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#IP3">
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">inositol-1,4,5-phosphate</dcterms:alternative>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">IP3</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Ca">
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">calcium</dcterms:alternative>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Ca</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#52613714-6246-4707-b530-70ae91b6d008">
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#0cf7313e-bf57-41a1-8616-bda1b637665e" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#55a2793b-eddb-4002-bea3-e777f38e8a9d">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#0c4612e9-8ffe-4ee3-bd16-cda5968105bf" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
This is the CellML description of Bhalla and Iyengar's mathematical
model of the phospholipase C (PLC) pathway (1999).
</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6bd45351-2aad-413a-8d7c-817930e6adbc">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">1999-01-15</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Gq">
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">G-substrate</dcterms:alternative>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Gq</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#88b63fa6-2d38-40d4-b22f-fb8b018ca5a5">
<vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The University of Auckland</vCard:Orgname>
<vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The Bioengineering Research Group</vCard:Orgunit>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#37542cf1-6523-483d-81dc-d50d5a96c6c2">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#ec46a1d0-fde9-4720-9fd4-b21e6949cec2">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#6da822a7-f1bf-4867-b3df-bbcbb332fc29" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0cf7313e-bf57-41a1-8616-bda1b637665e">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Upinder</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Bhalla</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">S</vCard:Other>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#bhalla_model_1999">
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Bag xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">signal_transduction</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Bhalla and Iyengar's Phopholipase C (beta) Pathway, 1999</dc:title>
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#55a2793b-eddb-4002-bea3-e777f38e8a9d" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#e95c8564-ee9d-4f77-bfd4-9799e9b00f41" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#ec46a1d0-fde9-4720-9fd4-b21e6949cec2" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#PIP2">
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">
Phosphatidylinositol-4,5-bisphosphate
</dcterms:alternative>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">PIP2</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#05904991-198d-432e-8aad-a676859a6636">
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#75c4b6e3-5bc7-4644-8ec4-c08c70423293" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#49b060ed-78c7-46e6-b876-5c6aa2c53f76">
<vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#88b63fa6-2d38-40d4-b22f-fb8b018ca5a5" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#8f533a90-e79e-4e5b-b81e-6577dc9c3682" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#37542cf1-6523-483d-81dc-d50d5a96c6c2" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#e95c8564-ee9d-4f77-bfd4-9799e9b00f41">
<bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">9888852</bqs:Pubmed_id>
<bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#9cd9dd55-c99f-49fa-af8a-2eb9abeb1b29" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#DAG">
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">diacylglycerol</dcterms:alternative>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">DAG</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8f533a90-e79e-4e5b-b81e-6577dc9c3682">
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">c.lloyd@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#542a64f5-b33a-4482-b72f-d726fee40a74">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Science</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#75c4b6e3-5bc7-4644-8ec4-c08c70423293">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Ravi</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Iyengar</vCard:Family>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9cd9dd55-c99f-49fa-af8a-2eb9abeb1b29">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#d4a1e3e8-bdd2-4778-8711-9c1bd349f333" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
Emergent Properties of Networks of Biological Signaling Pathways
</dc:title>
<bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">283</bqs:volume>
<bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">381</bqs:first_page>
<bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#542a64f5-b33a-4482-b72f-d726fee40a74" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#6bd45351-2aad-413a-8d7c-817930e6adbc" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
<bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">387</bqs:last_page>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#PLC">
<dcterms:alternative xmlns:dcterms="http://purl.org/dc/terms/">phospholipase C</dcterms:alternative>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">PLC</dc:title>
</rdf:Description>
</rdf:RDF>
</model>
