- Author:
- Michael Clerx <michael.clerx@nottingham.ac.uk>
- Date:
- 2022-01-27 23:34:45+00:00
- Desc:
- Added Sampson model
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/7fd/rawfile/7e0450c5e3cd4aaf12d2f86758cd63fae7087d79/sampson-2010.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model xmlns="http://www.cellml.org/cellml/1.0#"
xmlns:cellml="http://www.cellml.org/cellml/1.0#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
name="sampson_2010"
cmeta:id="sampson_2010">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/">
<rdf:Description rdf:about="#sampson_2010">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>electrophysiology</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<units name="A_per_F">
<unit units="gram" multiplier="1000"/>
<unit units="metre" exponent="2.0"/>
<unit units="second" exponent="-4.0"/>
<unit units="ampere" exponent="-1.0"/>
</units>
<units name="C_per_mmol">
<unit units="second" multiplier="1000"/>
<unit units="ampere"/>
<unit units="mole" exponent="-1.0"/>
</units>
<units name="J_per_mol_per_K">
<unit units="gram" multiplier="1000"/>
<unit units="metre" exponent="2.0"/>
<unit units="second" exponent="-2.0"/>
<unit units="kelvin" exponent="-1.0"/>
<unit units="mole" exponent="-1.0"/>
</units>
<units name="L_per_F_per_ms_times_1e0">
<unit units="gram"/>
<unit units="metre" exponent="5.0"/>
<unit units="second" exponent="-5.0"/>
<unit units="ampere" exponent="-2.0"/>
</units>
<units name="cm2">
<unit units="metre" exponent="2.0" multiplier="0.0001"/>
</units>
<units name="dimensionless_times_1e_minus_3">
<unit units="dimensionless" multiplier="0.001"/>
</units>
<units name="g_m4_per_s4_per_A2_times_1e2">
<unit units="gram" multiplier="100"/>
<unit units="metre" exponent="4.0"/>
<unit units="second" exponent="-4.0"/>
<unit units="ampere" exponent="-2.0"/>
</units>
<units name="m12_per_s_per_mol4_times_1e15">
<unit units="metre" exponent="12.0" multiplier="1000000000000000"/>
<unit units="second" exponent="-1.0"/>
<unit units="mole" exponent="-4.0"/>
</units>
<units name="m3_per_mol">
<unit units="metre" exponent="3.0"/>
<unit units="mole" exponent="-1.0"/>
</units>
<units name="m9_per_mol3">
<unit units="metre" exponent="9.0"/>
<unit units="mole" exponent="-3.0"/>
</units>
<units name="m9_per_s_per_mol3_times_1e12">
<unit units="metre" exponent="9.0" multiplier="1000000000000"/>
<unit units="second" exponent="-1.0"/>
<unit units="mole" exponent="-3.0"/>
</units>
<units name="mM">
<unit units="metre" exponent="-3.0"/>
<unit units="mole"/>
</units>
<units name="mM3">
<unit units="metre" exponent="-9.0"/>
<unit units="mole" exponent="3.0"/>
</units>
<units name="mM3_times_1e_minus_9">
<unit units="metre" exponent="-9.0" multiplier="1e-09"/>
<unit units="mole" exponent="3.0"/>
</units>
<units name="mM_per_ms">
<unit units="metre" exponent="-3.0" multiplier="1000"/>
<unit units="second" exponent="-1.0"/>
<unit units="mole"/>
</units>
<units name="mS_per_uF">
<unit units="second" exponent="-1.0" multiplier="1000"/>
</units>
<units name="mV">
<unit units="gram"/>
<unit units="metre" exponent="2.0"/>
<unit units="second" exponent="-3.0"/>
<unit units="ampere" exponent="-1.0"/>
</units>
<units name="mol4_per_m12">
<unit units="metre" exponent="-12.0"/>
<unit units="mole" exponent="4.0"/>
</units>
<units name="mol4_per_m12_times_1e_minus_12">
<unit units="metre" exponent="-12.0" multiplier="1e-12"/>
<unit units="mole" exponent="4.0"/>
</units>
<units name="ms">
<unit units="second" multiplier="0.001"/>
</units>
<units name="per_mM_per_ms">
<unit units="metre" exponent="3.0" multiplier="1000"/>
<unit units="second" exponent="-1.0"/>
<unit units="mole" exponent="-1.0"/>
</units>
<units name="per_mV">
<unit units="gram" exponent="-1.0"/>
<unit units="metre" exponent="-2.0"/>
<unit units="second" exponent="3.0"/>
<unit units="ampere"/>
</units>
<units name="per_mV_per_ms">
<unit units="gram" exponent="-1.0" multiplier="1000"/>
<unit units="metre" exponent="-2.0"/>
<unit units="second" exponent="2.0"/>
<unit units="ampere"/>
</units>
<units name="s3_A_mol_per_g_per_m5">
<unit units="gram" exponent="-1.0"/>
<unit units="metre" exponent="-5.0"/>
<unit units="second" exponent="3.0"/>
<unit units="ampere"/>
<unit units="mole"/>
</units>
<units name="uL">
<unit units="metre" exponent="3.0" multiplier="1e-09"/>
</units>
<component name="caflux">
<variable name="CaJSR" units="mM" public_interface="in"/>
<variable name="CaNSR" units="mM" public_interface="in"/>
<variable name="CaSS" units="mM" public_interface="in"/>
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="HTRPNCa" units="dimensionless" public_interface="out" initial_value="9.74145534599999974e-01"/>
<variable name="HTRPNtot" units="mM" initial_value="0.14"/>
<variable name="Jtr" units="mM_per_ms" public_interface="out"/>
<variable name="Jtrpn" units="mM_per_ms" public_interface="out"/>
<variable name="Jxfer" units="mM_per_ms" public_interface="out"/>
<variable name="LTRPNCa" units="dimensionless" public_interface="out" initial_value="7.05428108299999967e-02"/>
<variable name="LTRPNtot" units="mM" initial_value="0.07"/>
<variable name="caflux_HTRPNCa_a1" units="mS_per_uF"/>
<variable name="caflux_LTRPNCa_a1" units="mS_per_uF"/>
<variable name="khtrpn_minus" units="mS_per_uF" initial_value="6.6e-05"/>
<variable name="khtrpn_plus" units="per_mM_per_ms" initial_value="20.0"/>
<variable name="kltrpn_minus" units="mS_per_uF" initial_value="0.04"/>
<variable name="kltrpn_plus" units="per_mM_per_ms" initial_value="40.0"/>
<variable name="tautr" units="ms" initial_value="0.5747"/>
<variable name="tauxfer" units="ms" initial_value="26.7"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>khtrpn_plus</ci>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>HTRPNCa</ci>
</apply>
</apply>
<ci>caflux_HTRPNCa_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Jtr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaNSR</ci>
<ci>CaJSR</ci>
</apply>
<ci>tautr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Jtrpn</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>LTRPNtot</ci>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>HTRPNtot</ci>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jxfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaSS</ci>
<ci>Cai</ci>
</apply>
<ci>tauxfer</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kltrpn_plus</ci>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>LTRPNCa</ci>
</apply>
</apply>
<ci>caflux_LTRPNCa_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>caflux_HTRPNCa_a1</ci>
<apply>
<times/>
<ci>khtrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>caflux_LTRPNCa_a1</ci>
<apply>
<times/>
<ci>kltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</math>
</component>
<component name="calcium">
<variable name="CMDNtot" units="mM" initial_value="0.05"/>
<variable name="CSQNtot" units="mM" initial_value="15.0"/>
<variable name="CaJSR" units="mM" public_interface="out" initial_value="2.59679515799999983e-01"/>
<variable name="CaNSR" units="mM" public_interface="out" initial_value="2.59898837400000027e-01"/>
<variable name="CaSS" units="mM" public_interface="out" initial_value="1.24655751999999995e-04"/>
<variable name="Cai" units="mM" public_interface="out" initial_value="7.56225546699999958e-05"/>
<variable name="EGTAtot" units="mM" initial_value="0.0"/>
<variable name="ICa" units="A_per_F" public_interface="in"/>
<variable name="INaCa" units="A_per_F" public_interface="in"/>
<variable name="IpCa" units="A_per_F" public_interface="in"/>
<variable name="Jrel" units="mM_per_ms" public_interface="in"/>
<variable name="Jtr" units="mM_per_ms" public_interface="in"/>
<variable name="Jtrpn" units="mM_per_ms" public_interface="in"/>
<variable name="Jup" units="mM_per_ms" public_interface="in"/>
<variable name="Jxfer" units="mM_per_ms" public_interface="in"/>
<variable name="KmCMDN" units="mM" initial_value="0.00238"/>
<variable name="KmCSQN" units="mM" initial_value="0.8"/>
<variable name="KmEGTA" units="mM" initial_value="0.00015"/>
<variable name="VJSR" units="uL" public_interface="in"/>
<variable name="VNSR" units="uL" public_interface="in"/>
<variable name="VSS" units="uL" public_interface="in"/>
<variable name="Vmyo" units="uL" public_interface="in"/>
<variable name="beta_JSR" units="dimensionless"/>
<variable name="beta_SS" units="dimensionless"/>
<variable name="beta_i" units="dimensionless"/>
<variable name="calcium_CaSS_a3" units="mM_per_ms"/>
<variable name="calcium_Cai_a3" units="A_per_F"/>
<variable name="calcium_beta_JSR_b1" units="dimensionless"/>
<variable name="calcium_beta_SS_b1" units="dimensionless"/>
<variable name="calcium_beta_SS_b2" units="dimensionless"/>
<variable name="calcium_beta_i_b1" units="dimensionless"/>
<variable name="calcium_beta_i_b2" units="dimensionless"/>
<variable name="cell_a1" units="s3_A_mol_per_g_per_m5" public_interface="in"/>
<variable name="cell_a2" units="s3_A_mol_per_g_per_m5" public_interface="in"/>
<variable name="icat_I" units="A_per_F" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaJSR</ci>
</apply>
<apply>
<times/>
<ci>beta_JSR</ci>
<apply>
<minus/>
<ci>Jtr</ci>
<ci>Jrel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaNSR</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Jup</ci>
<ci>Vmyo</ci>
</apply>
<ci>VNSR</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Jtr</ci>
<ci>VJSR</ci>
</apply>
<ci>VNSR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaSS</ci>
</apply>
<apply>
<times/>
<ci>beta_SS</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>calcium_CaSS_a3</ci>
<apply>
<times/>
<ci>ICa</ci>
<ci>cell_a2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>icat_I</ci>
<ci>cell_a2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<ci>beta_i</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Jxfer</ci>
<ci>Jup</ci>
</apply>
<ci>Jtrpn</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>calcium_Cai_a3</ci>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
<ci>cell_a1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_JSR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>calcium_beta_JSR_b1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_SS</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>calcium_beta_SS_b1</ci>
</apply>
<ci>calcium_beta_SS_b2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>calcium_beta_i_b1</ci>
</apply>
<ci>calcium_beta_i_b2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>calcium_CaSS_a3</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Jrel</ci>
<ci>VJSR</ci>
</apply>
<ci>VSS</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Jxfer</ci>
<ci>Vmyo</ci>
</apply>
<ci>VSS</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>calcium_Cai_a3</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<ci>INaCa</ci>
</apply>
<ci>IpCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>calcium_beta_JSR_b1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQNtot</ci>
<ci>KmCSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaJSR</ci>
<ci>KmCSQN</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>calcium_beta_SS_b1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaSS</ci>
<ci>KmCMDN</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>calcium_beta_SS_b2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaSS</ci>
<ci>KmEGTA</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>calcium_beta_i_b1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>KmCMDN</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>calcium_beta_i_b2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>KmEGTA</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="cell">
<variable name="Acap" units="cm2" initial_value="0.0003912"/>
<variable name="F" units="C_per_mmol" public_interface="in"/>
<variable name="VJSR" units="uL" public_interface="out" initial_value="1.36e-07"/>
<variable name="VNSR" units="uL" public_interface="out" initial_value="1.785e-06"/>
<variable name="VSS" units="uL" public_interface="out" initial_value="1.08e-09"/>
<variable name="Vmyo" units="uL" public_interface="out" initial_value="2.196e-05"/>
<variable name="a1" units="s3_A_mol_per_g_per_m5" public_interface="out"/>
<variable name="a2" units="s3_A_mol_per_g_per_m5" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
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<divide/>
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<times/>
<apply>
<times/>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
<cn cellml:units="g_m4_per_s4_per_A2_times_1e2">1000.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<divide/>
<ci>Acap</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>VSS</ci>
</apply>
<ci>F</ci>
</apply>
<cn cellml:units="g_m4_per_s4_per_A2_times_1e2">1000.0</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="engine">
<variable name="HTRPNCa" units="dimensionless" public_interface="in"/>
<variable name="LTRPNCa" units="dimensionless" public_interface="in"/>
<variable name="O2" units="dimensionless" public_interface="in"/>
<variable name="ryr_C1" units="dimensionless" public_interface="in"/>
<variable name="ryr_C2" units="dimensionless" public_interface="in"/>
<variable name="time" units="ms" public_interface="out"/>
</component>
<component name="extra">
<variable name="Cao" units="mM" public_interface="out" initial_value="2.0"/>
<variable name="Ko" units="mM" public_interface="out" initial_value="4.0"/>
<variable name="Nao" units="mM" public_interface="out" initial_value="138.0"/>
</component>
<component name="ical">
<variable name="C0" units="dimensionless" initial_value="8.74379838900000039e-01"/>
<variable name="C0_to_C1" units="mS_per_uF"/>
<variable name="C0_to_CCa0" units="mS_per_uF"/>
<variable name="C1" units="dimensionless" initial_value="2.55268330899999993e-02"/>
<variable name="C1_to_C0" units="mS_per_uF"/>
<variable name="C1_to_C2" units="mS_per_uF"/>
<variable name="C1_to_CCa1" units="mS_per_uF"/>
<variable name="C2" units="dimensionless" initial_value="2.79463949400000000e-04"/>
<variable name="C2_to_C1" units="mS_per_uF"/>
<variable name="C2_to_C3" units="mS_per_uF"/>
<variable name="C2_to_CCa2" units="mS_per_uF"/>
<variable name="C3" units="dimensionless" initial_value="1.35979496400000004e-06"/>
<variable name="C3_to_C2" units="mS_per_uF"/>
<variable name="C3_to_C4" units="mS_per_uF"/>
<variable name="C3_to_CCa3" units="mS_per_uF"/>
<variable name="C4" units="dimensionless" initial_value="2.48115507400000008e-09"/>
<variable name="C4_to_C3" units="mS_per_uF"/>
<variable name="C4_to_CCa4" units="mS_per_uF"/>
<variable name="CCa0" units="dimensionless" initial_value="8.89536543300000065e-02"/>
<variable name="CCa0_to_C0" units="mS_per_uF"/>
<variable name="CCa0_to_CCa1" units="mS_per_uF"/>
<variable name="CCa1" units="dimensionless" initial_value="1.03878563100000005e-02"/>
<variable name="CCa1_to_C1" units="mS_per_uF"/>
<variable name="CCa1_to_CCa0" units="mS_per_uF"/>
<variable name="CCa1_to_CCa2" units="mS_per_uF"/>
<variable name="CCa2" units="dimensionless" initial_value="4.54899679899999998e-04"/>
<variable name="CCa2_to_C2" units="mS_per_uF"/>
<variable name="CCa2_to_CCa1" units="mS_per_uF"/>
<variable name="CCa2_to_CCa3" units="mS_per_uF"/>
<variable name="CCa3" units="dimensionless" initial_value="8.85360913299999938e-06"/>
<variable name="CCa3_to_C3" units="mS_per_uF"/>
<variable name="CCa3_to_CCa2" units="mS_per_uF"/>
<variable name="CCa3_to_CCa4" units="mS_per_uF"/>
<variable name="CCa4" units="dimensionless" initial_value="6.46181672899999939e-08"/>
<variable name="CCa4_to_C4" units="mS_per_uF"/>
<variable name="CCa4_to_CCa3" units="mS_per_uF"/>
<variable name="CaSS" units="mM" public_interface="in"/>
<variable name="Cao" units="mM" public_interface="in"/>
<variable name="ICa" units="A_per_F" public_interface="out"/>
<variable name="ICaK" units="A_per_F" public_interface="out"/>
<variable name="ICahalf" units="A_per_F"/>
<variable name="ICamax" units="A_per_F" public_interface="out"/>
<variable name="Ki" units="mM" public_interface="in"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Open" units="dimensionless" initial_value="1.85837559400000008e-10"/>
<variable name="PCa" units="L_per_F_per_ms_times_1e0" public_interface="out"/>
<variable name="PK" units="L_per_F_per_ms_times_1e0"/>
<variable name="PKprime" units="L_per_F_per_ms_times_1e0"/>
<variable name="Pscale" units="dimensionless" initial_value="1.8"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="VFFRT" units="C_per_mmol" public_interface="in"/>
<variable name="VFRT" units="dimensionless" public_interface="in"/>
<variable name="aL" units="dimensionless" initial_value="2.0"/>
<variable name="alpha" units="mS_per_uF"/>
<variable name="alpha_prime" units="mS_per_uF"/>
<variable name="bL" units="dimensionless" initial_value="2.0"/>
<variable name="beta" units="mS_per_uF"/>
<variable name="beta_prime" units="mS_per_uF"/>
<variable name="fL" units="mS_per_uF" initial_value="0.3"/>
<variable name="gL" units="mS_per_uF" initial_value="4.0"/>
<variable name="gamma" units="mS_per_uF"/>
<variable name="ical_C0_a1" units="mS_per_uF"/>
<variable name="ical_C0_a2" units="mS_per_uF"/>
<variable name="ical_C1_a1" units="mS_per_uF"/>
<variable name="ical_C1_a2" units="mS_per_uF"/>
<variable name="ical_C2_a1" units="mS_per_uF"/>
<variable name="ical_C2_a2" units="mS_per_uF"/>
<variable name="ical_C3_a1" units="mS_per_uF"/>
<variable name="ical_C3_a2" units="mS_per_uF"/>
<variable name="ical_C4_a1" units="mS_per_uF"/>
<variable name="ical_C4_a2" units="mS_per_uF"/>
<variable name="ical_CCa0_a1" units="mS_per_uF"/>
<variable name="ical_CCa0_a2" units="mS_per_uF"/>
<variable name="ical_CCa1_a1" units="mS_per_uF"/>
<variable name="ical_CCa1_a2" units="mS_per_uF"/>
<variable name="ical_CCa2_a1" units="mS_per_uF"/>
<variable name="ical_CCa2_a2" units="mS_per_uF"/>
<variable name="ical_CCa3_a1" units="mS_per_uF"/>
<variable name="ical_CCa3_a2" units="mS_per_uF"/>
<variable name="ical_CCa4_a1" units="mS_per_uF"/>
<variable name="ical_CCa4_a2" units="mS_per_uF"/>
<variable name="ical_ICaK_a1" units="mM"/>
<variable name="ical_ICaK_a2" units="dimensionless"/>
<variable name="ical_ICamax_a1" units="mM"/>
<variable name="ical_ICamax_a2" units="dimensionless"/>
<variable name="ical_yCa_yCa_inf_a1" units="dimensionless" initial_value="0.82"/>
<variable name="imax" units="A_per_F"/>
<variable name="omega" units="mS_per_uF" initial_value="0.0025"/>
<variable name="tau_yCa" units="ms"/>
<variable name="time" units="ms" public_interface="in"/>
<variable name="yCa" units="dimensionless" initial_value="9.98998351100000015e-01"/>
<variable name="yCa_inf" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0</ci>
</apply>
<apply>
<minus/>
<ci>ical_C0_a2</ci>
<ci>ical_C0_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C0_to_C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C0_to_CCa0</ci>
<ci>gamma</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<minus/>
<ci>ical_C1_a2</ci>
<ci>ical_C1_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C1_to_C0</ci>
<ci>beta</ci>
</apply>
<apply>
<eq/>
<ci>C1_to_C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C1_to_CCa1</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C0_to_CCa0</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<ci>ical_C2_a2</ci>
<ci>ical_C2_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_CCa2</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C1_to_CCa1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<minus/>
<ci>ical_C3_a2</ci>
<ci>ical_C3_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_C4</ci>
<ci>alpha</ci>
</apply>
<apply>
<eq/>
<ci>C3_to_CCa3</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C2_to_CCa2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4</ci>
</apply>
<apply>
<minus/>
<ci>ical_C4_a2</ci>
<ci>ical_C4_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_to_C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_to_CCa4</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C3_to_CCa3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa0</ci>
</apply>
<apply>
<minus/>
<ci>ical_CCa0_a2</ci>
<ci>ical_CCa0_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa0_to_C0</ci>
<ci>omega</ci>
</apply>
<apply>
<eq/>
<ci>CCa0_to_CCa1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa1</ci>
</apply>
<apply>
<minus/>
<ci>ical_CCa1_a2</ci>
<ci>ical_CCa1_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa1_to_C1</ci>
<apply>
<divide/>
<ci>CCa0_to_C0</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa1_to_CCa0</ci>
<ci>beta_prime</ci>
</apply>
<apply>
<eq/>
<ci>CCa1_to_CCa2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa2</ci>
</apply>
<apply>
<minus/>
<ci>ical_CCa2_a2</ci>
<ci>ical_CCa2_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_C2</ci>
<apply>
<divide/>
<ci>CCa1_to_C1</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_CCa1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_CCa3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa3</ci>
</apply>
<apply>
<minus/>
<ci>ical_CCa3_a2</ci>
<ci>ical_CCa3_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_C3</ci>
<apply>
<divide/>
<ci>CCa2_to_C2</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_CCa2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_CCa4</ci>
<ci>alpha_prime</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa4</ci>
</apply>
<apply>
<minus/>
<ci>ical_CCa4_a2</ci>
<ci>ical_CCa4_a1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa4_to_C4</ci>
<apply>
<divide/>
<ci>CCa3_to_C3</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa4_to_CCa3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ICa</ci>
<apply>
<times/>
<apply>
<times/>
<ci>ICamax</ci>
<ci>yCa</ci>
</apply>
<ci>Open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ICaK</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>PKprime</ci>
<ci>Open</ci>
</apply>
<ci>yCa</ci>
</apply>
<ci>VFFRT</ci>
</apply>
<apply>
<divide/>
<ci>ical_ICaK_a1</ci>
<ci>ical_ICaK_a2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ICahalf</ci>
<apply>
<minus/>
<cn cellml:units="A_per_F">0.265</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ICamax</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>PCa</ci>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
<ci>VFFRT</ci>
</apply>
<apply>
<divide/>
<ci>ical_ICamax_a1</ci>
<ci>ical_ICamax_a2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Open</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>fL</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<ci>gL</ci>
<ci>Open</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>PCa</ci>
<apply>
<times/>
<ci>Pscale</ci>
<cn cellml:units="L_per_F_per_ms_times_1e0">0.2469</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>PK</ci>
<apply>
<times/>
<ci>Pscale</ci>
<cn cellml:units="L_per_F_per_ms_times_1e0">0.0004574</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>PKprime</ci>
<apply>
<divide/>
<ci>PK</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<ci>imax</ci>
<ci>ICahalf</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<cn cellml:units="dimensionless">1.2</cn>
</apply>
<cn cellml:units="mS_per_uF">0.416</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.012</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">35.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_prime</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<cn cellml:units="dimensionless">0.45</cn>
</apply>
<cn cellml:units="mS_per_uF">0.049</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.065</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">22.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_prime</ci>
<apply>
<divide/>
<ci>beta</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.6</cn>
<cn cellml:units="per_mM_per_ms">0.09233</cn>
</apply>
<ci>CaSS</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C0_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C0_to_C1</ci>
<ci>C0_to_CCa0</ci>
</apply>
<ci>C0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C0_a2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C1_to_C0</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>CCa0_to_C0</ci>
<ci>CCa0</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C1_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C1_to_C0</ci>
<ci>C1_to_C2</ci>
</apply>
<ci>C1_to_CCa1</ci>
</apply>
<ci>C1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C1_a2</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C0_to_C1</ci>
<ci>C0</ci>
</apply>
<apply>
<times/>
<ci>C2_to_C1</ci>
<ci>C2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CCa1_to_C1</ci>
<ci>CCa1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C2_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C2_to_C1</ci>
<ci>C2_to_C3</ci>
</apply>
<ci>C2_to_CCa2</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C2_a2</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C1_to_C2</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>C3_to_C2</ci>
<ci>C3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CCa2_to_C2</ci>
<ci>CCa2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C3_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C3_to_C2</ci>
<ci>C3_to_C4</ci>
</apply>
<ci>C3_to_CCa3</ci>
</apply>
<ci>C3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C3_a2</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C2_to_C3</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<ci>C4_to_C3</ci>
<ci>C4</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CCa3_to_C3</ci>
<ci>CCa3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C4_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>C4_to_C3</ci>
<ci>fL</ci>
</apply>
<ci>C4_to_CCa4</ci>
</apply>
<ci>C4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_C4_a2</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>C3_to_C4</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<ci>gL</ci>
<ci>Open</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CCa4_to_C4</ci>
<ci>CCa4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_CCa0_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CCa0_to_CCa1</ci>
<ci>CCa0_to_C0</ci>
</apply>
<ci>CCa0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_CCa0_a2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa1_to_CCa0</ci>
<ci>CCa1</ci>
</apply>
<apply>
<times/>
<ci>C0_to_CCa0</ci>
<ci>C0</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_CCa1_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>CCa1_to_CCa0</ci>
<ci>CCa1_to_CCa2</ci>
</apply>
<ci>CCa1_to_C1</ci>
</apply>
<ci>CCa1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_CCa1_a2</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa0_to_CCa1</ci>
<ci>CCa0</ci>
</apply>
<apply>
<times/>
<ci>CCa2_to_CCa1</ci>
<ci>CCa2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>C1_to_CCa1</ci>
<ci>C1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_CCa2_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>CCa2_to_CCa1</ci>
<ci>CCa2_to_CCa3</ci>
</apply>
<ci>CCa2_to_C2</ci>
</apply>
<ci>CCa2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ical_CCa2_a2</ci>
<apply>
<plus/>
<apply>
<plus/>
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<exp/>
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<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.028</cn>
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<ci>V</ci>
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<apply>
<eq/>
<ci>iks_xs_wt_alpha</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn type="e-notation" cellml:units="per_mV_per_ms">3.3<sep/>-5</cn>
<cn cellml:units="per_mV">0.13</cn>
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<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">11.0</cn>
</apply>
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<apply>
<divide/>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_mV_per_ms">3.3<sep/>-5</cn>
<apply>
<plus/>
<ci>V</ci>
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<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.13</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">11.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
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<apply>
<eq/>
<ci>iks_xs_wt_beta</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.0001</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.015</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xf_wt</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>iks_xf_wt_alpha</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>xf_wt</ci>
</apply>
</apply>
<apply>
<times/>
<ci>iks_xf_wt_beta</ci>
<ci>xf_wt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xs_wt</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>iks_xs_wt_alpha</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>xs_wt</ci>
</apply>
</apply>
<apply>
<times/>
<ci>iks_xs_wt_beta</ci>
<ci>xs_wt</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="inaca">
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="Cao" units="mM" public_interface="in"/>
<variable name="INaCa" units="A_per_F" public_interface="out"/>
<variable name="KmCa" units="mM" initial_value="1.38"/>
<variable name="KmNa" units="mM" initial_value="87.5"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="VFRT" units="dimensionless" public_interface="in"/>
<variable name="a1" units="mol4_per_m12"/>
<variable name="a2" units="mol4_per_m12"/>
<variable name="a3" units="dimensionless"/>
<variable name="a4" units="mM"/>
<variable name="a5" units="m9_per_mol3"/>
<variable name="eta" units="dimensionless" initial_value="0.35"/>
<variable name="kNaCa" units="A_per_F" initial_value="0.44"/>
<variable name="ksat" units="dimensionless" initial_value="0.2"/>
<variable name="nao3" units="mM3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<ci>kNaCa</ci>
<ci>a5</ci>
</apply>
<apply>
<minus/>
<ci>a1</ci>
<ci>a2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>a4</ci>
<ci>a3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<ci>eta</ci>
<ci>VFRT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>VFRT</ci>
</apply>
</apply>
<ci>nao3</ci>
</apply>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a3</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<ci>ksat</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>VFRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a4</ci>
<apply>
<plus/>
<ci>KmCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a5</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">5000.0</cn>
<apply>
<plus/>
<apply>
<power/>
<ci>KmNa</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>nao3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>nao3</ci>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</math>
</component>
<component name="inak">
<variable name="INaK" units="A_per_F" public_interface="out"/>
<variable name="INaKmax" units="A_per_F" initial_value="1.5"/>
<variable name="KmKo" units="mM" initial_value="1.5"/>
<variable name="KmNai" units="mM" initial_value="20.0"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="VFRT" units="dimensionless" public_interface="in"/>
<variable name="fNaK" units="dimensionless"/>
<variable name="inak_INaK_a1" units="dimensionless"/>
<variable name="inak_INaK_a2" units="dimensionless"/>
<variable name="inak_fNaK_a1" units="dimensionless"/>
<variable name="inak_fNaK_a2" units="dimensionless"/>
<variable name="sigma" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INaK</ci>
<apply>
<times/>
<apply>
<times/>
<ci>INaKmax</ci>
<ci>fNaK</ci>
</apply>
<apply>
<divide/>
<ci>inak_INaK_a1</ci>
<ci>inak_INaK_a2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fNaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>inak_fNaK_a1</ci>
<ci>inak_fNaK_a2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>inak_INaK_a1</ci>
<apply>
<divide/>
<ci>Ko</ci>
<apply>
<plus/>
<ci>Ko</ci>
<ci>KmKo</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>inak_INaK_a2</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>KmNai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>inak_fNaK_a1</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>VFRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>inak_fNaK_a2</ci>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.33</cn>
</apply>
<ci>VFRT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<cn cellml:units="dimensionless">7.0</cn>
</apply>
</apply>
</math>
</component>
<component name="ipca">
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="IpCa" units="A_per_F" public_interface="out"/>
<variable name="IpCamax" units="A_per_F" initial_value="0.05"/>
<variable name="KmpCa" units="mM" initial_value="0.0005"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IpCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>IpCamax</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>KmpCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="isus">
<variable name="EK" units="mV" public_interface="in"/>
<variable name="Isus" units="A_per_F" public_interface="out"/>
<variable name="Isusmax" units="mS_per_uF" initial_value="0.0919908"/>
<variable name="V" units="mV" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Isus</ci>
<apply>
<times/>
<apply>
<times/>
<ci>Isusmax</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">20.0</cn>
</apply>
</apply>
<cn cellml:units="mV">12.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ito">
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<variable name="C0_to_C1" units="mS_per_uF"/>
<variable name="C0_to_CI0" units="mS_per_uF"/>
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<variable name="C1_to_C0" units="mS_per_uF"/>
<variable name="C1_to_C2" units="mS_per_uF"/>
<variable name="C1_to_CI1" units="mS_per_uF"/>
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<variable name="C2_to_C1" units="mS_per_uF"/>
<variable name="C2_to_C3" units="mS_per_uF"/>
<variable name="C2_to_CI2" units="mS_per_uF"/>
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<variable name="C3_to_C2" units="mS_per_uF"/>
<variable name="C3_to_CI3" units="mS_per_uF"/>
<variable name="C3_to_O" units="mS_per_uF"/>
<variable name="CI0" units="dimensionless" initial_value="1.41240034599999995e-02"/>
<variable name="CI0_to_C0" units="mS_per_uF"/>
<variable name="CI0_to_CI1" units="mS_per_uF"/>
<variable name="CI1" units="dimensionless" initial_value="1.10576340999999998e-02"/>
<variable name="CI1_to_C1" units="mS_per_uF"/>
<variable name="CI1_to_CI0" units="mS_per_uF"/>
<variable name="CI1_to_CI2" units="mS_per_uF"/>
<variable name="CI2" units="dimensionless" initial_value="4.37517185700000023e-03"/>
<variable name="CI2_to_C2" units="mS_per_uF"/>
<variable name="CI2_to_CI1" units="mS_per_uF"/>
<variable name="CI2_to_CI3" units="mS_per_uF"/>
<variable name="CI3" units="dimensionless" initial_value="9.10523457199999969e-04"/>
<variable name="CI3_to_C3" units="mS_per_uF"/>
<variable name="CI3_to_CI2" units="mS_per_uF"/>
<variable name="CI3_to_OI" units="mS_per_uF"/>
<variable name="EK" units="mV" public_interface="in"/>
<variable name="G" units="mS_per_uF" initial_value="1.52138159999999995e-01"/>
<variable name="Ito1" units="A_per_F" public_interface="out"/>
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<variable name="OI" units="dimensionless" initial_value="5.71714766299999999e-05"/>
<variable name="OI_to_CI3" units="mS_per_uF"/>
<variable name="OI_to_O" units="mS_per_uF"/>
<variable name="O_to_C3" units="mS_per_uF"/>
<variable name="O_to_OI" units="mS_per_uF"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="aa" units="per_mV" initial_value="0.028983"/>
<variable name="ai" units="per_mV" initial_value="3.73015999999999994e-04"/>
<variable name="alpha_act43" units="mS_per_uF"/>
<variable name="alpha_inact43" units="mS_per_uF"/>
<variable name="alphaa0" units="mS_per_uF" initial_value="0.543708"/>
<variable name="alphai0" units="mS_per_uF" initial_value="0.0498424"/>
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<variable name="ba" units="per_mV" initial_value="0.0468437"/>
<variable name="beta_act43" units="mS_per_uF"/>
<variable name="beta_inact43" units="mS_per_uF"/>
<variable name="betaa0" units="mS_per_uF" initial_value="0.080185"/>
<variable name="betai0" units="mS_per_uF" initial_value="8.19481999999999958e-04"/>
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<variable name="ito_C0_a1" units="mS_per_uF"/>
<variable name="ito_C0_a2" units="mS_per_uF"/>
<variable name="ito_C1_a1" units="mS_per_uF"/>
<variable name="ito_C1_a2" units="mS_per_uF"/>
<variable name="ito_C2_a1" units="mS_per_uF"/>
<variable name="ito_C2_a2" units="mS_per_uF"/>
<variable name="ito_C3_a1" units="mS_per_uF"/>
<variable name="ito_C3_a2" units="mS_per_uF"/>
<variable name="ito_CI0_a1" units="mS_per_uF"/>
<variable name="ito_CI0_a2" units="mS_per_uF"/>
<variable name="ito_CI1_a1" units="mS_per_uF"/>
<variable name="ito_CI1_a2" units="mS_per_uF"/>
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<variable name="ito_CI2_a2" units="mS_per_uF"/>
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<variable name="ito_CI3_a2" units="mS_per_uF"/>
<variable name="ito_OI_a1" units="mS_per_uF"/>
<variable name="ito_OI_a2" units="mS_per_uF"/>
<variable name="ito_O_a1" units="mS_per_uF"/>
<variable name="ito_O_a2" units="mS_per_uF"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<apply>
<diff/>
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<minus/>
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<eq/>
<ci>C0_to_C1</ci>
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<times/>
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<ci>alpha_act43</ci>
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<eq/>
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<eq/>
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<diff/>
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<minus/>
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<eq/>
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<eq/>
<ci>C1_to_C2</ci>
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<times/>
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<ci>alpha_act43</ci>
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<eq/>
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<times/>
<ci>f1</ci>
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<eq/>
<apply>
<diff/>
<bvar>
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<apply>
<minus/>
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<ci>ito_C2_a1</ci>
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<eq/>
<ci>C2_to_C1</ci>
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<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>beta_act43</ci>
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<eq/>
<ci>C2_to_C3</ci>
<apply>
<times/>
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<ci>alpha_act43</ci>
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<eq/>
<ci>C2_to_CI2</ci>
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<times/>
<ci>f2</ci>
<ci>beta_inact43</ci>
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<eq/>
<apply>
<diff/>
<bvar>
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<ci>C3</ci>
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<apply>
<minus/>
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<ci>ito_C3_a1</ci>
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<apply>
<eq/>
<ci>C3_to_C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>beta_act43</ci>
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<eq/>
<ci>C3_to_CI3</ci>
<apply>
<times/>
<ci>f3</ci>
<ci>beta_inact43</ci>
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<apply>
<eq/>
<ci>C3_to_O</ci>
<ci>alpha_act43</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>CI0</ci>
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<apply>
<minus/>
<ci>ito_CI0_a2</ci>
<ci>ito_CI0_a1</ci>
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</apply>
<apply>
<eq/>
<ci>CI0_to_C0</ci>
<ci>alpha_inact43</ci>
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<eq/>
<ci>CI0_to_CI1</ci>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.0</cn>
<ci>b1</ci>
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<ci>alpha_act43</ci>
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<eq/>
<apply>
<diff/>
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<apply>
<minus/>
<ci>ito_CI1_a2</ci>
<ci>ito_CI1_a1</ci>
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<apply>
<eq/>
<ci>CI1_to_C1</ci>
<apply>
<divide/>
<ci>alpha_inact43</ci>
<ci>b1</ci>
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<apply>
<eq/>
<ci>CI1_to_CI0</ci>
<apply>
<divide/>
<ci>beta_act43</ci>
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<apply>
<eq/>
<ci>CI1_to_CI2</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>b2</ci>
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<ci>alpha_act43</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<minus/>
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<divide/>
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<times/>
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<divide/>
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<diff/>
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<minus/>
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<times/>
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<ci>f3</ci>
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<apply>
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<apply>
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<ci>beta_act43</ci>
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<ci>O_to_OI</ci>
<apply>
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<ci>beta_inact43</ci>
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<eq/>
<ci>alpha_act43</ci>
<apply>
<times/>
<ci>alphaa0</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>aa</ci>
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<apply>
<eq/>
<ci>alpha_inact43</ci>
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<exp/>
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<times/>
<apply>
<minus/>
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<eq/>
<ci>beta_act43</ci>
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<exp/>
<apply>
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<eq/>
<ci>beta_inact43</ci>
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<exp/>
<apply>
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<ci>C0_to_CI0</ci>
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<apply>
<plus/>
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<apply>
<times/>
<ci>CI0_to_C0</ci>
<ci>CI0</ci>
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<eq/>
<ci>ito_C1_a1</ci>
<apply>
<times/>
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<plus/>
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<ci>C1_to_C0</ci>
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<ci>C1_to_CI1</ci>
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<apply>
<plus/>
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<plus/>
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<ci>C2_to_C1</ci>
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<times/>
<ci>CI1_to_C1</ci>
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<ci>C0_to_C1</ci>
<ci>C0</ci>
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<apply>
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<apply>
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<plus/>
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<plus/>
<ci>C2_to_C3</ci>
<ci>C2_to_C1</ci>
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<ci>C2_to_CI2</ci>
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<apply>
<plus/>
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<plus/>
<apply>
<times/>
<ci>C3_to_C2</ci>
<ci>C3</ci>
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<apply>
<times/>
<ci>CI2_to_C2</ci>
<ci>CI2</ci>
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<apply>
<times/>
<ci>C1_to_C2</ci>
<ci>C1</ci>
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<apply>
<eq/>
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<apply>
<times/>
<apply>
<plus/>
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<plus/>
<ci>C3_to_O</ci>
<ci>C3_to_C2</ci>
</apply>
<ci>C3_to_CI3</ci>
</apply>
<ci>C3</ci>
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<eq/>
<ci>ito_C3_a2</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>O_to_C3</ci>
<ci>O</ci>
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<apply>
<times/>
<ci>CI3_to_C3</ci>
<ci>CI3</ci>
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<times/>
<ci>C2_to_C3</ci>
<ci>C2</ci>
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<apply>
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<ci>ito_CI0_a1</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI0_to_C0</ci>
<ci>CI0_to_CI1</ci>
</apply>
<ci>CI0</ci>
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<ci>ito_CI0_a2</ci>
<apply>
<plus/>
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<times/>
<ci>C0_to_CI0</ci>
<ci>C0</ci>
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<apply>
<times/>
<ci>CI1_to_CI0</ci>
<ci>CI1</ci>
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<apply>
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<plus/>
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<plus/>
<ci>CI1_to_CI2</ci>
<ci>CI1_to_C1</ci>
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<ci>CI1_to_CI0</ci>
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<ci>CI1</ci>
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<plus/>
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<plus/>
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<ci>CI2_to_CI1</ci>
<ci>CI2</ci>
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<times/>
<ci>C1_to_CI1</ci>
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<ci>CI0_to_CI1</ci>
<ci>CI0</ci>
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<times/>
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<plus/>
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<plus/>
<ci>CI2_to_CI3</ci>
<ci>CI2_to_C2</ci>
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<ci>CI2_to_CI1</ci>
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<ci>CI2</ci>
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<ci>ito_CI2_a2</ci>
<apply>
<plus/>
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<plus/>
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<ci>CI3_to_CI2</ci>
<ci>CI3</ci>
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<times/>
<ci>C2_to_CI2</ci>
<ci>C2</ci>
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<times/>
<ci>CI1_to_CI2</ci>
<ci>CI1</ci>
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<times/>
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<plus/>
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<plus/>
<ci>CI3_to_OI</ci>
<ci>CI3_to_C3</ci>
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<ci>CI3_to_CI2</ci>
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<ci>CI3</ci>
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<plus/>
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<ci>C3_to_CI3</ci>
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<ci>CI2_to_CI3</ci>
<ci>CI2</ci>
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<plus/>
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<ci>OI</ci>
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<ci>O_to_OI</ci>
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<times/>
<ci>CI3_to_OI</ci>
<ci>CI3</ci>
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<ci>ito_O_a1</ci>
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<times/>
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<plus/>
<ci>O_to_C3</ci>
<ci>O_to_OI</ci>
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<ci>O</ci>
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<eq/>
<ci>ito_O_a2</ci>
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<ci>C3_to_O</ci>
<ci>C3</ci>
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<ci>OI_to_O</ci>
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</apply>
<ci>b11</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IC3</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>IC2</ci>
<ci>b11</ci>
</apply>
<apply>
<times/>
<ci>C3</ci>
<ci>b3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IC3</ci>
<apply>
<plus/>
<ci>a11</ci>
<ci>a3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IF</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>IS1</ci>
<ci>b4</ci>
</apply>
<apply>
<times/>
<ci>O</ci>
<ci>a2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IC2</ci>
<ci>a12</ci>
</apply>
</apply>
<apply>
<times/>
<ci>C1</ci>
<ci>b3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IF</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>a4</ci>
<ci>b2</ci>
</apply>
<ci>b12</ci>
</apply>
<ci>a3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INa</ci>
<apply>
<times/>
<apply>
<times/>
<ci>GNa</ci>
<apply>
<plus/>
<ci>O</ci>
<ci>BO</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IS1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>IS2</ci>
<ci>b5</ci>
</apply>
<apply>
<times/>
<ci>IF</ci>
<ci>a4</ci>
</apply>
</apply>
<apply>
<times/>
<ci>IS1</ci>
<apply>
<plus/>
<ci>a5</ci>
<ci>b4</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IS2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>IS1</ci>
<ci>a5</ci>
</apply>
<apply>
<times/>
<ci>IS2</ci>
<ci>b5</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>IF</ci>
<ci>b2</ci>
</apply>
<apply>
<times/>
<ci>BO</ci>
<ci>mu2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>C1</ci>
<ci>a13</ci>
</apply>
</apply>
<apply>
<times/>
<ci>O</ci>
<apply>
<plus/>
<apply>
<plus/>
<ci>a2</ci>
<ci>b13</ci>
</apply>
<ci>mu1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a11</ci>
<apply>
<divide/>
<cn cellml:units="mS_per_uF">3.802</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">17.0</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">150.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a12</ci>
<apply>
<divide/>
<cn cellml:units="mS_per_uF">3.802</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">15.0</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.23</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">150.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a13</ci>
<apply>
<divide/>
<cn cellml:units="mS_per_uF">3.802</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">12.0</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.25</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">150.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF">9.178</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="mV">29.68</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a3</ci>
<apply>
<times/>
<cn type="e-notation" cellml:units="mS_per_uF">3.79329999999999996<sep/>-7</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">7.7</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a4</ci>
<apply>
<divide/>
<ci>a2</ci>
<cn cellml:units="dimensionless">100.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>a5</ci>
<apply>
<divide/>
<ci>a2</ci>
<cn cellml:units="dimensionless">95000.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>b11</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.1917</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">20.3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>b12</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">5.0</cn>
</apply>
</apply>
<cn cellml:units="mV">20.3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>b13</ci>
<apply>
<times/>
<cn cellml:units="mS_per_uF">0.22</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
<cn cellml:units="mV">20.3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>b2</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<ci>a3</ci>
<ci>a2</ci>
</apply>
<ci>a13</ci>
</apply>
<apply>
<times/>
<ci>b3</ci>
<ci>b13</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>b3</ci>
<apply>
<plus/>
<cn cellml:units="mS_per_uF">0.0084</cn>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_mV_per_ms">2<sep/>-5</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>b4</ci>
<ci>a3</ci>
</apply>
<apply>
<eq/>
<ci>b5</ci>
<apply>
<divide/>
<ci>a3</ci>
<cn cellml:units="dimensionless">50.0</cn>
</apply>
</apply>
</math>
</component>
<component name="nernst">
<variable name="EK" units="mV" public_interface="out"/>
<variable name="ENa" units="mV" public_interface="out"/>
<variable name="Ki" units="mM" public_interface="in"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nai" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="RTF" units="mV" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>EK</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ENa</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="phys">
<variable name="F" units="C_per_mmol" public_interface="out" initial_value="96.5"/>
<variable name="R" units="J_per_mol_per_K" initial_value="8.315"/>
<variable name="RTF" units="mV" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="310.0"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="VFFRT" units="C_per_mmol" public_interface="out"/>
<variable name="VFRT" units="dimensionless" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>RTF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>VFFRT</ci>
<apply>
<times/>
<ci>F</ci>
<ci>VFRT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>VFRT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RTF</ci>
</apply>
</apply>
</math>
</component>
<component name="potassium">
<variable name="ICaK" units="A_per_F" public_interface="in"/>
<variable name="IHCN" units="A_per_F" public_interface="in"/>
<variable name="IK1" units="A_per_F" public_interface="in"/>
<variable name="IK_tot" units="A_per_F"/>
<variable name="IKr" units="A_per_F" public_interface="in"/>
<variable name="IKs" units="A_per_F" public_interface="in"/>
<variable name="INaK" units="A_per_F" public_interface="in"/>
<variable name="Isus" units="A_per_F" public_interface="in"/>
<variable name="Ito1" units="A_per_F" public_interface="in"/>
<variable name="Ki" units="mM" public_interface="out" initial_value="1.22483450199999993e+02"/>
<variable name="cell_a1" units="s3_A_mol_per_g_per_m5" public_interface="in"/>
<variable name="i_stim" units="A_per_F" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IK_tot</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>IKr</ci>
<ci>IKs</ci>
</apply>
<ci>IK1</ci>
</apply>
<ci>ICaK</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>IHCN</ci>
</apply>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<ci>Isus</ci>
</apply>
<ci>i_stim</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>INaK</ci>
</apply>
</apply>
<ci>Ito1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>cell_a1</ci>
</apply>
<ci>IK_tot</ci>
</apply>
</apply>
</math>
</component>
<component name="ryr">
<variable name="C1" units="dimensionless" public_interface="out" initial_value="4.65590390899999984e-01"/>
<variable name="C2" units="dimensionless" public_interface="out" initial_value="5.33775261499999987e-01"/>
<variable name="CaJSR" units="mM" public_interface="in"/>
<variable name="CaSS" units="mM" public_interface="in"/>
<variable name="Jrel" units="mM_per_ms" public_interface="out"/>
<variable name="O1" units="dimensionless" initial_value="6.34345983199999957e-04"/>
<variable name="O2" units="dimensionless" public_interface="out" initial_value="2.58066283699999986e-09"/>
<variable name="kaminus" units="mS_per_uF" initial_value="0.576"/>
<variable name="kaplus" units="m12_per_s_per_mol4_times_1e15" initial_value="0.01215"/>
<variable name="kbminus" units="mS_per_uF" initial_value="1.93"/>
<variable name="kbplus" units="m9_per_s_per_mol3_times_1e12" initial_value="0.00405"/>
<variable name="kcminus" units="mS_per_uF" initial_value="0.0008"/>
<variable name="kcplus" units="mS_per_uF" initial_value="0.1"/>
<variable name="ryr_C1_a2" units="mol4_per_m12_times_1e_minus_12"/>
<variable name="ryr_O2_a1" units="mM3_times_1e_minus_9"/>
<variable name="time" units="ms" public_interface="in"/>
<variable name="v1" units="mS_per_uF" initial_value="1.8"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>kaplus</ci>
</apply>
<ci>ryr_C1_a2</ci>
</apply>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>kaminus</ci>
<ci>O1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kcplus</ci>
<ci>O1</ci>
</apply>
<apply>
<times/>
<ci>kcminus</ci>
<ci>C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jrel</ci>
<apply>
<times/>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>O1</ci>
<ci>O2</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>CaJSR</ci>
<ci>CaSS</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2</ci>
</apply>
</apply>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kbplus</ci>
<ci>ryr_O2_a1</ci>
</apply>
<ci>O1</ci>
</apply>
<apply>
<times/>
<ci>kbminus</ci>
<ci>O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ryr_C1_a2</ci>
<apply>
<power/>
<apply>
<times/>
<ci>CaSS</ci>
<cn cellml:units="dimensionless_times_1e_minus_3">1000.0</cn>
</apply>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ryr_O2_a1</ci>
<apply>
<power/>
<apply>
<times/>
<ci>CaSS</ci>
<cn cellml:units="dimensionless_times_1e_minus_3">1000.0</cn>
</apply>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</math>
</component>
<component name="serca">
<variable name="CaNSR" units="mM" public_interface="in"/>
<variable name="Cai" units="mM" public_interface="in"/>
<variable name="Jup" units="mM_per_ms" public_interface="out"/>
<variable name="KSR" units="dimensionless" initial_value="1.2"/>
<variable name="Kfb" units="mM" initial_value="0.000168"/>
<variable name="Krb" units="mM" initial_value="3.29"/>
<variable name="Nfb" units="dimensionless" initial_value="1.2"/>
<variable name="Nrb" units="dimensionless" initial_value="1.0"/>
<variable name="fb" units="dimensionless"/>
<variable name="rb" units="dimensionless"/>
<variable name="vmaxf" units="mM_per_ms" initial_value="7.48e-05"/>
<variable name="vmaxr" units="mM_per_ms" initial_value="0.000318"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Jup</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KSR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>vmaxf</ci>
<ci>fb</ci>
</apply>
<apply>
<times/>
<ci>vmaxr</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>fb</ci>
</apply>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kfb</ci>
</apply>
<ci>Nfb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>rb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>CaNSR</ci>
<ci>Krb</ci>
</apply>
<ci>Nrb</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium">
<variable name="IHCN" units="A_per_F" public_interface="in"/>
<variable name="INa" units="A_per_F" public_interface="in"/>
<variable name="INa1" units="A_per_F" public_interface="in"/>
<variable name="INaCa" units="A_per_F" public_interface="in"/>
<variable name="INaK" units="A_per_F" public_interface="in"/>
<variable name="INa_tot" units="A_per_F"/>
<variable name="Nai" units="mM" public_interface="out" initial_value="1.20687050500000002e+01"/>
<variable name="cell_a1" units="s3_A_mol_per_g_per_m5" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INa_tot</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>INa</ci>
<ci>INa1</ci>
</apply>
<apply>
<divide/>
<ci>IHCN</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<apply>
<plus/>
<ci>INaCa</ci>
<ci>INaK</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>cell_a1</ci>
</apply>
<ci>INa_tot</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="caflux" component_2="calcium"/>
<map_variables variable_1="CaJSR" variable_2="CaJSR"/>
<map_variables variable_1="CaNSR" variable_2="CaNSR"/>
<map_variables variable_1="CaSS" variable_2="CaSS"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Jtr" variable_2="Jtr"/>
<map_variables variable_1="Jtrpn" variable_2="Jtrpn"/>
<map_variables variable_1="Jxfer" variable_2="Jxfer"/>
</connection>
<connection>
<map_components component_1="caflux" component_2="engine"/>
<map_variables variable_1="HTRPNCa" variable_2="HTRPNCa"/>
<map_variables variable_1="LTRPNCa" variable_2="LTRPNCa"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="cell"/>
<map_variables variable_1="VJSR" variable_2="VJSR"/>
<map_variables variable_1="VNSR" variable_2="VNSR"/>
<map_variables variable_1="VSS" variable_2="VSS"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="cell_a1" variable_2="a1"/>
<map_variables variable_1="cell_a2" variable_2="a2"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="engine"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ical"/>
<map_variables variable_1="CaSS" variable_2="CaSS"/>
<map_variables variable_1="ICa" variable_2="ICa"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="icat"/>
<map_variables variable_1="icat_I" variable_2="I"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="inaca"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ipca"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="IpCa" variable_2="IpCa"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr"/>
<map_variables variable_1="CaJSR" variable_2="CaJSR"/>
<map_variables variable_1="CaSS" variable_2="CaSS"/>
<map_variables variable_1="Jrel" variable_2="Jrel"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="serca"/>
<map_variables variable_1="CaNSR" variable_2="CaNSR"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Jup" variable_2="Jup"/>
</connection>
<connection>
<map_components component_1="cell" component_2="phys"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="cell" component_2="potassium"/>
<map_variables variable_1="a1" variable_2="cell_a1"/>
</connection>
<connection>
<map_components component_1="cell" component_2="sodium"/>
<map_variables variable_1="a1" variable_2="cell_a1"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ical"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="icat"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ihcn"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ikr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="iks"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ito"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="membrane"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="nav11"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="nav15"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="potassium"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ryr"/>
<map_variables variable_1="O2" variable_2="O2"/>
<map_variables variable_1="ryr_C1" variable_2="C1"/>
<map_variables variable_1="ryr_C2" variable_2="C2"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="sodium"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="extra" component_2="ical"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="extra" component_2="ik1"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="extra" component_2="ikr"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="extra" component_2="inaca"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="extra" component_2="inak"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="extra" component_2="nernst"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="ical" component_2="icat"/>
<map_variables variable_1="ICamax" variable_2="ICamax"/>
<map_variables variable_1="PCa" variable_2="PCa"/>
</connection>
<connection>
<map_components component_1="ical" component_2="membrane"/>
<map_variables variable_1="ICa" variable_2="ICa"/>
<map_variables variable_1="ICaK" variable_2="ICaK"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ical" component_2="phys"/>
<map_variables variable_1="VFFRT" variable_2="VFFRT"/>
<map_variables variable_1="VFRT" variable_2="VFRT"/>
</connection>
<connection>
<map_components component_1="ical" component_2="potassium"/>
<map_variables variable_1="ICaK" variable_2="ICaK"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="icat" component_2="membrane"/>
<map_variables variable_1="I" variable_2="icat_I"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ihcn" component_2="membrane"/>
<map_variables variable_1="IHCN" variable_2="IHCN"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ihcn" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
</connection>
<connection>
<map_components component_1="ihcn" component_2="phys"/>
<map_variables variable_1="VFRT" variable_2="VFRT"/>
</connection>
<connection>
<map_components component_1="ihcn" component_2="potassium"/>
<map_variables variable_1="IHCN" variable_2="IHCN"/>
</connection>
<connection>
<map_components component_1="ihcn" component_2="sodium"/>
<map_variables variable_1="IHCN" variable_2="IHCN"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="membrane"/>
<map_variables variable_1="IK1" variable_2="IK1"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="potassium"/>
<map_variables variable_1="IK1" variable_2="IK1"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="membrane"/>
<map_variables variable_1="IKr" variable_2="IKr"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="potassium"/>
<map_variables variable_1="IKr" variable_2="IKr"/>
</connection>
<connection>
<map_components component_1="iks" component_2="membrane"/>
<map_variables variable_1="IKs" variable_2="IKs"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="iks" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="iks" component_2="potassium"/>
<map_variables variable_1="IKs" variable_2="IKs"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="membrane"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="phys"/>
<map_variables variable_1="VFRT" variable_2="VFRT"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="sodium"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="inak" component_2="membrane"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
</connection>
<connection>
<map_components component_1="inak" component_2="phys"/>
<map_variables variable_1="VFRT" variable_2="VFRT"/>
</connection>
<connection>
<map_components component_1="inak" component_2="potassium"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
</connection>
<connection>
<map_components component_1="inak" component_2="sodium"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="ipca" component_2="membrane"/>
<map_variables variable_1="IpCa" variable_2="IpCa"/>
</connection>
<connection>
<map_components component_1="isus" component_2="membrane"/>
<map_variables variable_1="Isus" variable_2="Isus"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="isus" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="isus" component_2="potassium"/>
<map_variables variable_1="Isus" variable_2="Isus"/>
</connection>
<connection>
<map_components component_1="ito" component_2="membrane"/>
<map_variables variable_1="Ito1" variable_2="Ito1"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ito" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="ito" component_2="potassium"/>
<map_variables variable_1="Ito1" variable_2="Ito1"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="nav11"/>
<map_variables variable_1="INa1" variable_2="INa1"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="nav15"/>
<map_variables variable_1="INa" variable_2="INa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="phys"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="potassium"/>
<map_variables variable_1="i_stim" variable_2="i_stim"/>
</connection>
<connection>
<map_components component_1="nav11" component_2="nernst"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
</connection>
<connection>
<map_components component_1="nav11" component_2="sodium"/>
<map_variables variable_1="INa1" variable_2="INa1"/>
</connection>
<connection>
<map_components component_1="nav15" component_2="nernst"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
</connection>
<connection>
<map_components component_1="nav15" component_2="sodium"/>
<map_variables variable_1="INa" variable_2="INa"/>
</connection>
<connection>
<map_components component_1="nernst" component_2="phys"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="nernst" component_2="potassium"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="nernst" component_2="sodium"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<rdf:RDF>
<rdf:Description rdf:about="#amplitude">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_amplitude"/>
</rdf:Description>
<rdf:Description rdf:about="#duration">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_duration"/>
</rdf:Description>
<rdf:Description rdf:about="#offset">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_offset"/>
</rdf:Description>
<rdf:Description rdf:about="#period">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_period"/>
</rdf:Description>
</rdf:RDF>
</model>
