This folder contains the effect of phospholamban (PLB) on every reaction in the SERCA model. PLBp is both a reactant and product. It is the phosphorylated form, which does not inhibit SERCA. Therefore, all rate constants for every reaction are increased by the same amount/multiplier should PLBp increase. As rate constants apply for a baseline value of PLBp, change mu_PLBp used for reaction fluxes to mu_PLBp_effective, where mu_PLBp_effective = mu_PLBp_baseline - mu_PLBp (can't directly use q, as this cannot be negative as would result in NaN mu value) For reaction P1 <=> P2 Reactions now look like P1 + PLBp_baseline - PLBp <=> P2 + PLBp_baseline - PLBp Get rid of the minus sign: same thing as P1 + PLBp_baseline + PLBp <=> P2 + PLBp_baseline + PLBp PLBp and PLBp_baseline are the same species using the same K value as they exist in the same compartment For the stoichiometric matrix, reformulate reaction to P1 + 2PLBp <=> P2 + 2PLBp (n = 2 for PLBp)