- Author:
- ssu655 <ssu655@aucklanduni.ac.nz>
- Date:
- 2020-03-11 15:48:45+13:00
- Desc:
- removed out-of-date README file
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/5c8/rawfile/92bbea105c383cf6e6e8571e851a9c5811f19b63/Mnm1_p7.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="Neurotransmitter" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="per_s" units_ref="per_s"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
<units name="per_mM" units_ref="per_mM"/>
<units name="per_mM_s" units_ref="per_mM_s"/>
</import>
<import xlink:href="Neuron.cellml">
<component component_ref="Neuron" name="Neuron"/>
</import>
<import xlink:href="Astrocyte.cellml">
<component component_ref="Astrocyte" name="Astrocyte"/>
</import>
<import xlink:href="Blood.cellml">
<component component_ref="Blood" name="Blood"/>
</import>
<import xlink:href="NVC_parameters.cellml">
<component component_ref="Parameters" name="Parameters"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="Mnm1">
<variable name="t" private_interface="out" public_interface="in" units="second"/>
<!-- State variables-->
<variable name="q_stimulus" units="mM"/>
<!--{init: 0.0}-->
<variable initial_value="0.0" name="q_inputDelay" private_interface="out" units="mM"/>
<variable initial_value="0.0" name="q_Glu" private_interface="out" units="mM"/>
<variable name="y" units="dimensionless"/>
<variable name="q_oHb" private_interface="in" units="mM"/>
<variable name="q_dHb" private_interface="in" units="mM"/>
<variable name="q_O_2" private_interface="in" units="mM"/>
<variable name="q_glucose" private_interface="in" units="mM"/>
<!-- Parameters-->
<variable name="k_flow" private_interface="in" units="per_s"/>
<variable name="k_flow_basal" private_interface="in" units="per_s"/>
<variable name="k_Stimulating" private_interface="in" units="per_s"/>
<variable name="k_Inhibiting" private_interface="in" units="per_s"/>
<variable name="k_y" private_interface="in" units="dimensionless"/>
<variable name="k_metabolic" private_interface="in" units="per_s"/>
<variable name="k_neurotrans" private_interface="in" units="per_s"/>
<variable name="k_sink_Input" private_interface="in" units="per_s"/>
<variable name="k_sink_Glu" private_interface="in" units="per_s"/>
<variable initial_value="187.95" name="y_steady" units="dimensionless"/>
<!-- ODEs-->
<!-- case (t > 54.5{second}) and (t < 55{second}):
1{mM};-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>q_stimulus</ci>
<piecewise>
<piece>
<cn cellml:units="mM">1</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>t</ci>
<cn cellml:units="second">50</cn>
</apply>
<apply>
<lt/>
<ci>t</ci>
<cn cellml:units="second">50.5</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="mM">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_inputDelay</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_metabolic</ci>
<ci>q_stimulus</ci>
</apply>
<apply>
<times/>
<ci>k_sink_Input</ci>
<ci>q_inputDelay</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Glu</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_neurotrans</ci>
<ci>q_stimulus</ci>
</apply>
<apply>
<times/>
<ci>q_Glu</ci>
<ci>k_sink_Glu</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_y</ci>
<ci>q_oHb</ci>
</apply>
<ci>q_dHb</ci>
</apply>
<ci>y_steady</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="Mnm1">
<component_ref component="Astrocyte"/>
<component_ref component="Neuron"/>
<component_ref component="Blood"/>
<component_ref component="Parameters"/>
</component_ref>
</group>
<connection>
<map_components component_1="environment" component_2="Mnm1"/>
<map_variables variable_1="time" variable_2="t"/>
</connection>
<connection>
<map_components component_1="Mnm1" component_2="Blood"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_inputDelay" variable_2="q_inputDelay"/>
<map_variables variable_1="q_oHb" variable_2="q_oHb"/>
<map_variables variable_1="q_dHb" variable_2="q_dHb"/>
<map_variables variable_1="q_glucose" variable_2="q_glucose"/>
<map_variables variable_1="q_O_2" variable_2="q_O_2"/>
<map_variables variable_1="k_flow" variable_2="k_flow"/>
<map_variables variable_1="k_Stimulating" variable_2="k_Stimulating"/>
<map_variables variable_1="k_Inhibiting" variable_2="k_Inhibiting"/>
</connection>
<connection>
<map_components component_1="Mnm1" component_2="Astrocyte"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_Glu" variable_2="q_Glu"/>
</connection>
<connection>
<map_components component_1="Mnm1" component_2="Neuron"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_Glu" variable_2="q_Glu"/>
</connection>
<connection>
<map_components component_1="Astrocyte" component_2="Neuron"/>
<map_variables variable_1="q_NO" variable_2="q_NO"/>
</connection>
<connection>
<map_components component_1="Astrocyte" component_2="Blood"/>
<map_variables variable_1="q_HETE" variable_2="q_HETE"/>
<map_variables variable_1="q_EET" variable_2="q_EET"/>
<map_variables variable_1="q_PG" variable_2="q_PG"/>
</connection>
<connection>
<map_components component_1="Neuron" component_2="Blood"/>
<map_variables variable_1="q_cGMP" variable_2="q_cGMP"/>
</connection>
<connection>
<map_components component_1="Mnm1" component_2="Parameters"/>
<map_variables variable_1="k_y" variable_2="k_y"/>
<map_variables variable_1="k_metabolic" variable_2="k_metabolic"/>
<map_variables variable_1="k_neurotrans" variable_2="k_neurotrans"/>
<map_variables variable_1="k_sink_Input" variable_2="k_sink_Input"/>
<map_variables variable_1="k_sink_Glu" variable_2="k_sink_Glu"/>
<map_variables variable_1="k_flow_basal" variable_2="k_flow_basal"/>
</connection>
<connection>
<map_components component_1="Blood" component_2="Parameters"/>
<map_variables variable_1="k_1_f" variable_2="k_1_f"/>
<map_variables variable_1="k_1_b" variable_2="k_1_b"/>
<map_variables variable_1="k_basal" variable_2="k_basal"/>
<map_variables variable_1="k_flow_basal" variable_2="k_flow_basal"/>
<map_variables variable_1="proportion_1" variable_2="proportion_1"/>
<map_variables variable_1="proportion_2" variable_2="proportion_2"/>
<map_variables variable_1="b_1" variable_2="b_1"/>
<map_variables variable_1="b_2" variable_2="b_2"/>
<map_variables variable_1="b_3" variable_2="b_3"/>
<map_variables variable_1="b_4" variable_2="b_4"/>
<map_variables variable_1="q_O_2_body" variable_2="q_O_2_body"/>
<map_variables variable_1="q_oHb_body" variable_2="q_oHb_body"/>
<map_variables variable_1="q_dHb_body" variable_2="q_dHb_body"/>
<map_variables variable_1="q_G_body" variable_2="q_G_body"/>
</connection>
<connection>
<map_components component_1="Neuron" component_2="Parameters"/>
<map_variables variable_1="k_3" variable_2="k_3"/>
<map_variables variable_1="k_10" variable_2="k_10"/>
<map_variables variable_1="k_11" variable_2="k_11"/>
<map_variables variable_1="k_21" variable_2="k_21"/>
<map_variables variable_1="k_22" variable_2="k_22"/>
<map_variables variable_1="k_23" variable_2="k_23"/>
<map_variables variable_1="k_NO_sink" variable_2="k_NO_sink"/>
<map_variables variable_1="k_sink_N" variable_2="k_sink_N"/>
<map_variables variable_1="k_sink_C" variable_2="k_sink_C"/>
<map_variables variable_1="v_Ca_Nbas" variable_2="v_Ca_Nbas"/>
</connection>
<connection>
<map_components component_1="Astrocyte" component_2="Parameters"/>
<map_variables variable_1="k_2" variable_2="k_2"/>
<map_variables variable_1="k_4" variable_2="k_4"/>
<map_variables variable_1="k_5" variable_2="k_5"/>
<map_variables variable_1="k_6" variable_2="k_6"/>
<map_variables variable_1="k_7" variable_2="k_7"/>
<map_variables variable_1="k_8" variable_2="k_8"/>
<map_variables variable_1="k_9" variable_2="k_9"/>
<map_variables variable_1="k_12" variable_2="k_12"/>
<map_variables variable_1="k_13" variable_2="k_13"/>
<map_variables variable_1="k_14" variable_2="k_14"/>
<map_variables variable_1="k_15" variable_2="k_15"/>
<map_variables variable_1="k_16" variable_2="k_16"/>
<map_variables variable_1="k_17" variable_2="k_17"/>
<map_variables variable_1="k_18" variable_2="k_18"/>
<map_variables variable_1="k_19" variable_2="k_19"/>
<map_variables variable_1="k_20" variable_2="k_20"/>
<map_variables variable_1="km_1" variable_2="km_1"/>
<map_variables variable_1="km_2" variable_2="km_2"/>
<map_variables variable_1="k_sink_A" variable_2="k_sink_A"/>
<map_variables variable_1="k_sink_H" variable_2="k_sink_H"/>
<map_variables variable_1="k_sink_P" variable_2="k_sink_P"/>
<map_variables variable_1="k_sink_E" variable_2="k_sink_E"/>
<map_variables variable_1="v_Ca_Abas" variable_2="v_Ca_Abas"/>
<map_variables variable_1="q_PL" variable_2="q_PL"/>
</connection>
</model>
