- Author:
- ssu655 <ssu655@aucklanduni.ac.nz>
- Date:
- 2020-03-11 15:48:45+13:00
- Desc:
- removed out-of-date README file
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/5c8/rawfile/92bbea105c383cf6e6e8571e851a9c5811f19b63/Blood.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="Blood_module" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="per_s" units_ref="per_s"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
<units name="per_mM" units_ref="per_mM"/>
<units name="per_mM_s" units_ref="per_mM_s"/>
<units name="m3_per_s" units_ref="m3_per_s"/>
</import>
<import xlink:href="NVC_parameters.cellml">
<component component_ref="Parameters" name="Parameters"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="Blood">
<variable name="t" public_interface="in" units="second"/>
<!-- State variables-->
<variable initial_value="0" name="q_inputDelay" public_interface="in" units="mM"/>
<variable initial_value="5.545241097" name="q_oHb" public_interface="out" units="mM"/>
<variable initial_value="14.4547589" name="q_dHb" public_interface="out" units="mM"/>
<variable initial_value="0.797592534" name="q_O_2" public_interface="out" units="mM"/>
<variable initial_value="6.849233427" name="q_glucose" public_interface="out" units="mM"/>
<variable name="v_basal" units="mM_per_s"/>
<variable name="v_stim" units="mM_per_s"/>
<variable initial_value="82" name="q_HETE" public_interface="in" units="mM"/>
<variable initial_value="32" name="q_EET" public_interface="in" units="mM"/>
<variable initial_value="0.06" name="q_PG" public_interface="in" units="mM"/>
<variable initial_value="15" name="q_cGMP" public_interface="in" units="mM"/>
<!-- Parameters-->
<variable name="k_Stimulating" public_interface="out" units="per_s"/>
<variable name="k_Inhibiting" public_interface="out" units="per_s"/>
<variable name="k_Act" units="per_s"/>
<variable name="k_1_f" public_interface="in" units="per_s"/>
<variable name="k_1_b" public_interface="in" units="per_mM_s"/>
<variable name="k_basal" public_interface="in" units="per_mM_s"/>
<variable name="k_flow" public_interface="out" units="per_s"/>
<variable name="k_flow_basal" public_interface="in" units="per_s"/>
<variable name="proportion_1" public_interface="in" units="dimensionless"/>
<variable name="proportion_2" public_interface="in" units="dimensionless"/>
<variable name="b_1" public_interface="in" units="per_mM_s"/>
<variable name="b_2" public_interface="in" units="per_mM_s"/>
<variable name="b_3" public_interface="in" units="per_mM_s"/>
<variable name="b_4" public_interface="in" units="per_mM_s"/>
<variable name="q_O_2_body" public_interface="in" units="mM"/>
<variable name="q_oHb_body" public_interface="in" units="mM"/>
<variable name="q_dHb_body" public_interface="in" units="mM"/>
<variable name="q_G_body" public_interface="in" units="mM"/>
<!-- ODEs-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_Stimulating</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>b_1</ci>
<ci>q_cGMP</ci>
</apply>
<apply>
<times/>
<ci>b_2</ci>
<ci>q_PG</ci>
</apply>
<apply>
<times/>
<ci>b_3</ci>
<ci>q_EET</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_Inhibiting</ci>
<apply>
<times/>
<ci>b_4</ci>
<ci>q_HETE</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_Act</ci>
<apply>
<minus/>
<ci>k_Stimulating</ci>
<ci>k_Inhibiting</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_flow</ci>
<apply>
<plus/>
<ci>k_flow_basal</ci>
<ci>k_Act</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_basal</ci>
<apply>
<times/>
<ci>k_basal</ci>
<apply>
<power/>
<ci>q_O_2</ci>
<ci>proportion_1</ci>
</apply>
<ci>q_glucose</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_stim</ci>
<apply>
<times/>
<ci>q_inputDelay</ci>
<apply>
<power/>
<ci>q_O_2</ci>
<ci>proportion_2</ci>
</apply>
<ci>q_glucose</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_oHb</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_1_b</ci>
<ci>q_dHb</ci>
<ci>q_O_2</ci>
</apply>
<apply>
<times/>
<ci>k_1_f</ci>
<ci>q_oHb</ci>
</apply>
</apply>
<apply>
<times/>
<ci>q_oHb_body</ci>
<ci>k_flow</ci>
</apply>
</apply>
<apply>
<times/>
<ci>q_oHb</ci>
<ci>k_flow</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_dHb</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_1_f</ci>
<ci>q_oHb</ci>
</apply>
<apply>
<times/>
<ci>k_1_b</ci>
<ci>q_dHb</ci>
<ci>q_O_2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>q_dHb_body</ci>
<ci>k_flow</ci>
</apply>
</apply>
<apply>
<times/>
<ci>q_dHb</ci>
<ci>k_flow</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_O_2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_1_f</ci>
<ci>q_oHb</ci>
</apply>
<apply>
<times/>
<ci>k_1_b</ci>
<ci>q_dHb</ci>
<ci>q_O_2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>v_basal</ci>
<ci>proportion_1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>v_stim</ci>
<ci>proportion_2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>q_O_2_body</ci>
<ci>k_flow</ci>
</apply>
</apply>
<apply>
<times/>
<ci>q_O_2</ci>
<ci>k_flow</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_glucose</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>q_G_body</ci>
<ci>k_flow</ci>
</apply>
<apply>
<times/>
<ci>q_glucose</ci>
<ci>k_flow</ci>
</apply>
</apply>
<ci>v_basal</ci>
</apply>
<ci>v_stim</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="Blood"/>
<map_variables variable_1="time" variable_2="t"/>
</connection>
<connection>
<map_components component_1="Blood" component_2="Parameters"/>
<map_variables variable_1="k_1_f" variable_2="k_1_f"/>
<map_variables variable_1="k_1_b" variable_2="k_1_b"/>
<map_variables variable_1="k_basal" variable_2="k_basal"/>
<map_variables variable_1="k_flow_basal" variable_2="k_flow_basal"/>
<map_variables variable_1="proportion_1" variable_2="proportion_1"/>
<map_variables variable_1="proportion_2" variable_2="proportion_2"/>
<map_variables variable_1="b_1" variable_2="b_1"/>
<map_variables variable_1="b_2" variable_2="b_2"/>
<map_variables variable_1="b_3" variable_2="b_3"/>
<map_variables variable_1="b_4" variable_2="b_4"/>
<map_variables variable_1="q_O_2_body" variable_2="q_O_2_body"/>
<map_variables variable_1="q_oHb_body" variable_2="q_oHb_body"/>
<map_variables variable_1="q_dHb_body" variable_2="q_dHb_body"/>
<map_variables variable_1="q_G_body" variable_2="q_G_body"/>
</connection>
</model>
