Ni et al. 2017 Human atrial model

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No simplified view available for this workspace as no related exposures were found.

Workspace Summary

Description

Model of the human atrial action potential by Ni et al. (2017) Based on the code for the model by Ni et al. 2017 [1], which is an update of a model by Colman et al. (2013, 2017) [2, 3], which in turn was based on the 1998 model by Courtemanche et al. [4]. This version has the parameters for a right-atrial cell. [1] Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin Ni, Whittaker, Zhang et al. 2017. Frontiers in Physiology doi: 10.3389/fphys.2017.00946 [2] Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria. Colman, Aslanidi, Zhang et al. 2013. Journal of Physiology doi: 10.1113/jphysiol.2013.254987 [3] In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis. Colman, Ni, Zhang, et al. 2017 PLoS Computatioanl Biology doi: 10.1371/journal.pcbi.1005587 [4] Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model Courtemanche, Ramirez, Nattel 1998. American Journal of Physiology doi: 10.1152/ajpheart.1998.275.1.H301

Owner

Michael Clerx <cell@michaelclerx.com>

URI for git clone/pull/push

https://models.physiomeproject.org/workspace/5b0

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