- Author:
- AnandR <a.rampadarath@auckland.ac.nz>
- Date:
- 2019-09-11 14:20:00+12:00
- Desc:
- Added omex files
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/59c/rawfile/5235f140f05975a62ccea67e4854ea79ca6ed984/model/iyer_mazhari_winslow_2004.cellml
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A computational model of the human left-ventricular epicardial myocyte</title>
<author>
<firstname>Steven</firstname>
<surname>Niederer</surname>
<affiliation>
<shortaffil>Department of Physiology, Anatomy and Genetics, Oxford University</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model runs in OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: A computational model of the human left-ventricular epicardial myocyte is presented. Models of each of the major ionic currents present in these cells are formulated and validated using experimental data obtained from studies of recombinant human ion channels and/or whole-cell recording from single myocytes isolated from human left-ventricular subepicardium. Continuous-time Markov chain models for the gating of the fast Na(+) current, transient outward current, rapid component of the delayed rectifier current, and the L-type calcium current are modified to represent human data at physiological temperature. A new model for the gating of the slow component of the delayed rectifier current is formulated and validated against experimental data. Properties of calcium handling and exchanger currents are altered to appropriately represent the dynamics of intracellular ion concentrations. The model is able to both reproduce and predict a wide range of behaviors observed experimentally including action potential morphology, ionic currents, intracellular calcium transients, frequency dependence of action-potential duration, Ca(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation. The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte.</para>
<para>The original paper reference is cited below:</para>
<para>
A computational model of the human left-ventricular epicardial myocyte, Vivek Iyer, Reza Mazhari and Raimond L. Winslow, 2004,
<emphasis>Biophysical Journal</emphasis>
, 87, 1507-1525.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/15345532">PubMed ID: 15345532</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="iyer_2004.png" />
</imageobject>
</mediaobject>
<caption>
A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Iyer
<emphasis>et al.</emphasis>
2004 mathematical model of the human left-ventricular epicardial myocyte.
</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CCa3_to_CCa4</ci>
<ci>alpha_prime</ci>
</apply>
<apply>
<eq />
<ci>C1_to_C0</ci>
<ci>beta</ci>
</apply>
<apply>
<eq />
<ci>C2_to_C1</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3_to_C2</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C4_to_C3</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CCa1_to_CCa0</ci>
<ci>beta_prime</ci>
</apply>
<apply>
<eq />
<ci>CCa2_to_CCa1</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CCa3_to_CCa2</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CCa4_to_CCa3</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C0_to_CCa0</ci>
<ci>gamma</ci>
</apply>
<apply>
<eq />
<ci>C1_to_CCa1</ci>
<apply>
<times />
<ci>aL</ci>
<ci>C0_to_CCa0</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C2_to_CCa2</ci>
<apply>
<times />
<ci>aL</ci>
<ci>C1_to_CCa1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3_to_CCa3</ci>
<apply>
<times />
<ci>aL</ci>
<ci>C2_to_CCa2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C4_to_CCa4</ci>
<apply>
<times />
<ci>aL</ci>
<ci>C3_to_CCa3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CCa0_to_C0</ci>
<ci>omega</ci>
</apply>
<apply>
<eq />
<ci>CCa1_to_C1</ci>
<apply>
<divide />
<ci>CCa0_to_C0</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CCa2_to_C2</ci>
<apply>
<divide />
<ci>CCa1_to_C1</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CCa3_to_C3</ci>
<apply>
<divide />
<ci>CCa2_to_C2</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CCa4_to_C4</ci>
<apply>
<divide />
<ci>CCa3_to_C3</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C0</ci>
<apply>
<times />
<apply>
<plus />
<ci>C0_to_C1</ci>
<ci>C0_to_CCa0</ci>
</apply>
<ci>C0</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C0</ci>
<apply>
<plus />
<apply>
<times />
<ci>C1_to_C0</ci>
<ci>C1</ci>
</apply>
<apply>
<times />
<ci>CCa0_to_C0</ci>
<ci>CCa0</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C0</ci>
</apply>
<apply>
<minus />
<ci>a2_C0</ci>
<ci>a1_C0</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C1</ci>
<apply>
<times />
<apply>
<plus />
<ci>C1_to_C0</ci>
<ci>C1_to_C2</ci>
<ci>C1_to_CCa1</ci>
</apply>
<ci>C1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C1</ci>
<apply>
<plus />
<apply>
<times />
<ci>C0_to_C1</ci>
<ci>C0</ci>
</apply>
<apply>
<times />
<ci>C2_to_C1</ci>
<ci>C2</ci>
</apply>
<apply>
<times />
<ci>CCa1_to_C1</ci>
<ci>CCa1</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<minus />
<ci>a2_C1</ci>
<ci>a1_C1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C2</ci>
<apply>
<times />
<apply>
<plus />
<ci>C2_to_C1</ci>
<ci>C2_to_C3</ci>
<ci>C2_to_CCa2</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C2</ci>
<apply>
<plus />
<apply>
<times />
<ci>C1_to_C2</ci>
<ci>C1</ci>
</apply>
<apply>
<times />
<ci>C3_to_C2</ci>
<ci>C3</ci>
</apply>
<apply>
<times />
<ci>CCa2_to_C2</ci>
<ci>CCa2</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus />
<ci>a2_C2</ci>
<ci>a1_C2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C3</ci>
<apply>
<times />
<apply>
<plus />
<ci>C3_to_C2</ci>
<ci>C3_to_C4</ci>
<ci>C3_to_CCa3</ci>
</apply>
<ci>C3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C3</ci>
<apply>
<plus />
<apply>
<times />
<ci>C2_to_C3</ci>
<ci>C2</ci>
</apply>
<apply>
<times />
<ci>C4_to_C3</ci>
<ci>C4</ci>
</apply>
<apply>
<times />
<ci>CCa3_to_C3</ci>
<ci>CCa3</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<minus />
<ci>a2_C3</ci>
<ci>a1_C3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C4</ci>
<apply>
<times />
<apply>
<plus />
<ci>C4_to_C3</ci>
<ci>fL</ci>
<ci>C4_to_CCa4</ci>
</apply>
<ci>C4</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C4</ci>
<apply>
<plus />
<apply>
<times />
<ci>C3_to_C4</ci>
<ci>C3</ci>
</apply>
<apply>
<times />
<ci>gL</ci>
<ci>Open</ci>
</apply>
<apply>
<times />
<ci>CCa4_to_C4</ci>
<ci>CCa4</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C4</ci>
</apply>
<apply>
<minus />
<ci>a2_C4</ci>
<ci>a1_C4</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Open</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>fL</ci>
<ci>C4</ci>
</apply>
<apply>
<times />
<ci>gL</ci>
<ci>Open</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Ca0</ci>
<apply>
<times />
<apply>
<plus />
<ci>CCa0_to_CCa1</ci>
<ci>CCa0_to_C0</ci>
</apply>
<ci>CCa0</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_Ca0</ci>
<apply>
<plus />
<apply>
<times />
<ci>CCa1_to_CCa0</ci>
<ci>CCa1</ci>
</apply>
<apply>
<times />
<ci>C0_to_CCa0</ci>
<ci>C0</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa0</ci>
</apply>
<apply>
<minus />
<ci>a2_Ca0</ci>
<ci>a1_Ca0</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Ca1</ci>
<apply>
<times />
<apply>
<plus />
<ci>CCa1_to_CCa0</ci>
<ci>CCa1_to_CCa2</ci>
<ci>CCa1_to_C1</ci>
</apply>
<ci>CCa1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_Ca1</ci>
<apply>
<plus />
<apply>
<times />
<ci>CCa0_to_CCa1</ci>
<ci>CCa0</ci>
</apply>
<apply>
<times />
<ci>CCa2_to_CCa1</ci>
<ci>CCa2</ci>
</apply>
<apply>
<times />
<ci>C1_to_CCa1</ci>
<ci>C1</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa1</ci>
</apply>
<apply>
<minus />
<ci>a2_Ca1</ci>
<ci>a1_Ca1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Ca2</ci>
<apply>
<times />
<apply>
<plus />
<ci>CCa2_to_CCa1</ci>
<ci>CCa2_to_CCa3</ci>
<ci>CCa2_to_C2</ci>
</apply>
<ci>CCa2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_Ca2</ci>
<apply>
<plus />
<apply>
<times />
<ci>CCa1_to_CCa2</ci>
<ci>CCa1</ci>
</apply>
<apply>
<times />
<ci>CCa3_to_CCa2</ci>
<ci>CCa3</ci>
</apply>
<apply>
<times />
<ci>C2_to_CCa2</ci>
<ci>C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa2</ci>
</apply>
<apply>
<minus />
<ci>a2_Ca2</ci>
<ci>a1_Ca2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Ca3</ci>
<apply>
<times />
<apply>
<plus />
<ci>CCa3_to_CCa2</ci>
<ci>CCa3_to_CCa4</ci>
<ci>CCa3_to_C3</ci>
</apply>
<ci>CCa3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_Ca3</ci>
<apply>
<plus />
<apply>
<times />
<ci>CCa2_to_CCa3</ci>
<ci>CCa2</ci>
</apply>
<apply>
<times />
<ci>CCa4_to_CCa3</ci>
<ci>CCa4</ci>
</apply>
<apply>
<times />
<ci>C3_to_CCa3</ci>
<ci>C3</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa3</ci>
</apply>
<apply>
<minus />
<ci>a2_Ca3</ci>
<ci>a1_Ca3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Ca4</ci>
<apply>
<times />
<apply>
<plus />
<ci>CCa4_to_CCa3</ci>
<ci>CCa4_to_C4</ci>
</apply>
<ci>CCa4</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_Ca4</ci>
<apply>
<plus />
<apply>
<times />
<ci>CCa3_to_CCa4</ci>
<ci>CCa3</ci>
</apply>
<apply>
<times />
<ci>C4_to_CCa4</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CCa4</ci>
</apply>
<apply>
<minus />
<ci>a2_Ca4</ci>
<ci>a1_Ca4</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Cainf</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.82</cn>
</apply>
<apply>
<eq />
<ci>yCa_inf</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<divide />
<ci>a1_Cainf</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">28.5</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">7.8</cn>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
<ci>a1_Cainf</ci>
</apply>
</apply>
<apply>
<eq />
<ci>tau_yCa</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="ms">1</cn>
<apply>
<plus />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.00336336209452</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.5</cn>
<apply>
<exp />
<apply>
<divide />
<ci>V</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">5.53899874036055</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.00779046570737</cn>
<apply>
<exp />
<apply>
<divide />
<ci>V</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">49.51039631160386</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>yCa</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>yCa_inf</ci>
<ci>yCa</ci>
</apply>
<ci>tau_yCa</ci>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_REVERSAL_POTENTIALS">
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.Cao" name="Cao" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.Nai" name="Nai" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.a1" name="a1" units="mM" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.a2" name="a2" units="mM" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.Cai" name="Cai" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.EKs" name="EKs" public_interface="out" units="mV" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.ECa" name="ECa" public_interface="out" units="mV" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.Ki" name="Ki" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.ENa" name="ENa" public_interface="out" units="mV" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.RT_over_F" name="RT_over_F" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.Ko" name="Ko" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.Nao" name="Nao" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_REVERSAL_POTENTIALS.EK" name="EK" public_interface="out" units="mV" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ENa</ci>
<apply>
<times />
<ci>RT_over_F</ci>
<apply>
<ln />
<apply>
<divide />
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>EK</ci>
<apply>
<times />
<ci>RT_over_F</ci>
<apply>
<ln />
<apply>
<divide />
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a1</ci>
<apply>
<plus />
<ci>Ko</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.01833</cn>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2</ci>
<apply>
<plus />
<ci>Ki</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.01833</cn>
<ci>Nai</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>EKs</ci>
<apply>
<times />
<ci>RT_over_F</ci>
<apply>
<ln />
<apply>
<divide />
<ci>a1</ci>
<ci>a2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>ECa</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.5</cn>
<ci>RT_over_F</ci>
<apply>
<ln />
<apply>
<divide />
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_ICa_ICaK">
<variable cmeta:id="COMPUTE_ICa_ICaK.Cai" name="Cai" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_ICa_ICaK.Icabar" name="Icabar" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_ICa_ICaK.PK" name="PK" units="litre_per_farad_second" />
<variable cmeta:id="COMPUTE_ICa_ICaK.PCa" name="PCa" units="litre_per_farad_second" />
<variable cmeta:id="COMPUTE_ICa_ICaK.ICaK" name="ICaK" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_ICa_ICaK.ICahalf" initial_value="-0.265" name="ICahalf" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_ICa_ICaK.a2_Ca" name="a2_Ca" units="dimensionless" />
<variable cmeta:id="COMPUTE_ICa_ICaK.Cao" name="Cao" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_ICa_ICaK.a1_Ca" name="a1_Ca" units="mM" />
<variable cmeta:id="COMPUTE_ICa_ICaK.RT_over_F" name="RT_over_F" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_ICa_ICaK.PKprime" name="PKprime" units="litre_per_farad_second" />
<variable cmeta:id="COMPUTE_ICa_ICaK.ICa" name="ICa" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_ICa_ICaK.Open" name="Open" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_ICa_ICaK.ICamax" name="ICamax" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_ICa_ICaK.a1_K" name="a1_K" units="mM" />
<variable cmeta:id="COMPUTE_ICa_ICaK.a2_K" name="a2_K" units="dimensionless" />
<variable cmeta:id="COMPUTE_ICa_ICaK.VF_over_RT" name="VF_over_RT" units="dimensionless" />
<variable cmeta:id="COMPUTE_ICa_ICaK.Faraday" name="Faraday" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="COMPUTE_ICa_ICaK.Ko" name="Ko" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_ICa_ICaK.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_ICa_ICaK.VFsq_over_RT" name="VFsq_over_RT" units="coulomb_per_millimole" />
<variable cmeta:id="COMPUTE_ICa_ICaK.Ki" name="Ki" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_ICa_ICaK.yCa" name="yCa" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_ICa_ICaK.Pscale" initial_value="7" name="Pscale" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>PK</ci>
<apply>
<times />
<ci>Pscale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="litre_per_farad_second" type="e-notation">
4.574
<sep />
-7
</cn>
</apply>
</apply>
<apply>
<eq />
<ci>PCa</ci>
<apply>
<times />
<ci>Pscale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="litre_per_farad_second" type="e-notation">
2.469
<sep />
-4
</cn>
</apply>
</apply>
<apply>
<eq />
<ci>VF_over_RT</ci>
<apply>
<divide />
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq />
<ci>VFsq_over_RT</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1000</cn>
<ci>Faraday</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Ca</ci>
<apply>
<minus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM" type="e-notation">
1.0
<sep />
-3
</cn>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>Cao</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.341</cn>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2_Ca</ci>
<apply>
<minus />
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq />
<ci>ICamax</ci>
<apply>
<divide />
<apply>
<times />
<ci>PCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>VFsq_over_RT</ci>
<ci>a1_Ca</ci>
</apply>
<ci>a2_Ca</ci>
</apply>
</apply>
<apply>
<eq />
<ci>ICa</ci>
<apply>
<times />
<ci>ICamax</ci>
<ci>yCa</ci>
<ci>Open</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Icabar</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="uA_per_uF">0</cn>
<apply>
<geq />
<ci>ICamax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="uA_per_uF">0</cn>
</apply>
</piece>
<otherwise>
<ci>ICamax</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>PKprime</ci>
<apply>
<divide />
<ci>PK</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>Icabar</ci>
<ci>ICahalf</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a1_K</ci>
<apply>
<minus />
<apply>
<times />
<ci>Ki</ci>
<apply>
<exp />
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_K</ci>
<apply>
<minus />
<apply>
<exp />
<ci>VF_over_RT</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq />
<ci>ICaK</ci>
<apply>
<divide />
<apply>
<times />
<ci>PKprime</ci>
<ci>Open</ci>
<ci>yCa</ci>
<ci>VFsq_over_RT</ci>
<ci>a1_K</ci>
</apply>
<ci>a2_K</ci>
</apply>
</apply>
</math>
</component>
<component name="cell" />
<component name="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES">
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.a2" name="a2" units="F_M_per_coulomb" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.a1" name="a1" units="F_M_per_coulomb" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.C" name="C" units="mF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.INab" name="INab" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.IpCa" name="IpCa" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Cai" initial_value="0.8601192016e-4" name="Cai" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Jrel" name="Jrel" public_interface="in" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.beta_i" name="beta_i" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_CaJSR" initial_value="0.2852239446" name="CaJSR" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Rgas" initial_value="8.315" name="Rgas" public_interface="out" units="joule_per_mole_kelvin" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Jup" name="Jup" public_interface="in" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Cao" initial_value="2" name="Cao" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.time" name="time" public_interface="in" units="ms" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.IKv14_K" name="IKv14_K" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.i_Stim" name="i_Stim" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Ki" initial_value="0.1255589432e3" name="Ki" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.RT_over_F" name="RT_over_F" public_interface="out" units="mV" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_CaNSR" initial_value="0.2855294915" name="CaNSR" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Jtrpn" name="Jtrpn" public_interface="in" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.CaSS" initial_value="0.1420215245e-3" name="CaSS" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Nao" initial_value="138" name="Nao" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_V" initial_value="-0.9065755929e2" name="V" public_interface="out" units="mV" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.VJSR" initial_value="0.16e-6" name="VJSR" units="uL" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Faraday" initial_value="96.5" name="Faraday" public_interface="out" units="coulomb_per_millimole" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.VNSR" initial_value="2.1e-6" name="VNSR" units="uL" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Nai" initial_value="0.9798304162e1" name="Nai" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.VSS" initial_value="1.2e-9" name="VSS" units="uL" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Vmyo" initial_value="25.84e-6" name="Vmyo" units="uL" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.IKv14_Na" name="IKv14_Na" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.ICaK" name="ICaK" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.IKv43" name="IKv43" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.INaK" name="INaK" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.ICa" name="ICa" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.INaCa" name="INaCa" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Jtr" name="Jtr" public_interface="in" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Ko" initial_value="4" name="Ko" public_interface="out" units="mM" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Acap" initial_value="1.534e-4" name="Acap" units="cm2" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Ito1" name="Ito1" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.IKs" name="IKs" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.IK1" name="IK1" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.IKr" name="IKr" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.INa" name="INa" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.i_tot" name="i_tot" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Jxfer" name="Jxfer" public_interface="in" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.Temp" initial_value="310" name="Temp" units="kelvin" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.beta_SS" name="beta_SS" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.ICab" name="ICab" public_interface="in" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES.beta_JSR" name="beta_JSR" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>RT_over_F</ci>
<apply>
<divide />
<apply>
<times />
<ci>Rgas</ci>
<ci>Temp</ci>
</apply>
<ci>Faraday</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C</ci>
<apply>
<times />
<ci>Acap</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mF_per_cm2" type="e-notation">
1.0
<sep />
-3
</cn>
</apply>
</apply>
<apply>
<eq />
<ci>a1</ci>
<apply>
<divide />
<ci>C</ci>
<apply>
<times />
<ci>Vmyo</ci>
<ci>Faraday</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2</ci>
<apply>
<divide />
<ci>C</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>VSS</ci>
<ci>Faraday</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<times />
<apply>
<minus />
<apply>
<plus />
<ci>INa</ci>
<ci>INab</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<apply>
<plus />
<ci>INaCa</ci>
<ci>INaK</ci>
</apply>
</apply>
<ci>IKv14_Na</ci>
</apply>
</apply>
<ci>a1</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<times />
<apply>
<minus />
<apply>
<plus />
<apply>
<minus />
<apply>
<plus />
<ci>IKr</ci>
<ci>IKs</ci>
<ci>IK1</ci>
<ci>ICaK</ci>
<ci>i_Stim</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>INaK</ci>
</apply>
</apply>
<ci>IKv43</ci>
<ci>IKv14_K</ci>
</apply>
</apply>
<ci>a1</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<times />
<ci>beta_i</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<ci>Jxfer</ci>
<ci>Jup</ci>
</apply>
<ci>Jtrpn</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<apply>
<minus />
<ci>ICab</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>INaCa</ci>
</apply>
</apply>
<ci>IpCa</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.5</cn>
<ci>a1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CaSS</ci>
</apply>
<apply>
<times />
<ci>beta_SS</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<divide />
<apply>
<times />
<ci>Jrel</ci>
<ci>VJSR</ci>
</apply>
<ci>VSS</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>Jxfer</ci>
<ci>Vmyo</ci>
</apply>
<ci>VSS</ci>
</apply>
</apply>
<apply>
<times />
<ci>ICa</ci>
<ci>a2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CaJSR</ci>
</apply>
<apply>
<times />
<ci>beta_JSR</ci>
<apply>
<minus />
<ci>Jtr</ci>
<ci>Jrel</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CaNSR</ci>
</apply>
<apply>
<minus />
<apply>
<divide />
<apply>
<times />
<ci>Jup</ci>
<ci>Vmyo</ci>
</apply>
<ci>VNSR</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>Jtr</ci>
<ci>VJSR</ci>
</apply>
<ci>VNSR</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_tot</ci>
<apply>
<plus />
<ci>INa</ci>
<ci>ICa</ci>
<ci>ICaK</ci>
<ci>IKr</ci>
<ci>IKs</ci>
<ci>IK1</ci>
<ci>INaCa</ci>
<ci>INaK</ci>
<ci>Ito1</ci>
<ci>IpCa</ci>
<ci>ICab</ci>
<ci>INab</ci>
<ci>i_Stim</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<minus />
<ci>i_tot</ci>
</apply>
</apply>
</math>
</component>
<component name="INa">
<variable cmeta:id="INa.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="INa.Faraday" name="Faraday" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="INa.k34" name="k34" units="per_ms" />
<variable cmeta:id="INa.k32" name="k32" units="per_ms" />
<variable cmeta:id="INa.k76" name="k76" units="per_ms" />
<variable cmeta:id="INa.k125" name="k125" units="per_ms" />
<variable cmeta:id="INa.k1312" name="k1312" units="per_ms" />
<variable cmeta:id="INa.k1112" name="k1112" units="per_ms" />
<variable cmeta:id="INa.k1110" name="k1110" units="per_ms" />
<variable cmeta:id="INa.TNa" initial_value="294.16" name="TNa" units="kelvin" />
<variable cmeta:id="INa.KToverH" name="KToverH" units="per_ms" />
<variable cmeta:id="INa.k81" name="k81" units="per_ms" />
<variable cmeta:id="INa.na11" initial_value="0.005496292279" name="na11" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.na10" initial_value="0.05786120057" name="na10" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.na13" initial_value="4.17679396e-4" name="na13" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.na12" initial_value="1.957874519e-4" name="na12" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.RToverF" name="RToverF" public_interface="in" units="mV" />
<variable cmeta:id="INa.k23" name="k23" units="per_ms" />
<variable cmeta:id="INa.k67" name="k67" units="per_ms" />
<variable cmeta:id="INa.k21" name="k21" units="per_ms" />
<variable cmeta:id="INa.k65" name="k65" units="per_ms" />
<variable cmeta:id="INa.beta1" name="beta1" units="per_ms" />
<variable cmeta:id="INa.k613" name="k613" units="per_ms" />
<variable cmeta:id="INa.rho" name="rho" units="per_ms" />
<variable cmeta:id="INa.RTNa" name="RTNa" units="joule_per_mole" />
<variable cmeta:id="INa.k136" name="k136" units="per_ms" />
<variable cmeta:id="INa.k411" name="k411" units="per_ms" />
<variable cmeta:id="INa.k29" name="k29" units="per_ms" />
<variable cmeta:id="INa.Delta1" name="Delta1" units="per_ms" />
<variable cmeta:id="INa.mu" name="mu" units="per_ms" />
<variable cmeta:id="INa.epsilon" name="epsilon" units="per_ms" />
<variable cmeta:id="INa.k75" name="k75" units="per_ms" />
<variable cmeta:id="INa.FoverRT" name="FoverRT" units="per_mV" />
<variable cmeta:id="INa.Of" name="Of" units="per_ms" />
<variable cmeta:id="INa.Temp_Scale" name="Temp_Scale" units="dimensionless" />
<variable cmeta:id="INa.GammaGamma" name="GammaGamma" units="per_ms" />
<variable cmeta:id="INa.k12" name="k12" units="per_ms" />
<variable cmeta:id="INa.k56" name="k56" units="per_ms" />
<variable cmeta:id="INa.k57" name="k57" units="per_ms" />
<variable cmeta:id="INa.omega_na" name="omega_na" units="per_ms" />
<variable cmeta:id="INa.k109" name="k109" units="per_ms" />
<variable cmeta:id="INa.k54" name="k54" units="per_ms" />
<variable cmeta:id="INa.k98" name="k98" units="per_ms" />
<variable cmeta:id="INa.On" name="On" units="per_ms" />
<variable cmeta:id="INa.k103" name="k103" units="per_ms" />
<variable cmeta:id="INa.Cf" name="Cf" units="per_ms" />
<variable cmeta:id="INa.k18" name="k18" units="per_ms" />
<variable cmeta:id="INa.na3" initial_value="0.004552898364" name="na3" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.na4" initial_value="2.20520743e-4" name="na4" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.k1213" name="k1213" units="per_ms" />
<variable cmeta:id="INa.na1" initial_value="0.1437575649" name="na1" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.na2" initial_value="0.0417776208" name="na2" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.time" name="time" public_interface="in" units="ms" />
<variable cmeta:id="INa.k1211" name="k1211" units="per_ms" />
<variable cmeta:id="INa.Cn" name="Cn" units="per_ms" />
<variable cmeta:id="INa.k1011" name="k1011" units="per_ms" />
<variable cmeta:id="INa.na9" initial_value="0.2707214097" name="na9" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.parameter_a" name="parameter_a" units="dimensionless" />
<variable cmeta:id="INa.na7" initial_value="2.856607179e-9" name="na7" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.na8" initial_value="0.4749950008" name="na8" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.na5" initial_value="4.005266484e-6" name="na5" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.na6" initial_value="1.57442749e-8" name="na6" public_interface="out" units="dimensionless" />
<variable cmeta:id="INa.RTNaF" name="RTNaF" units="mV" />
<variable cmeta:id="INa.gamma1" name="gamma1" units="per_ms" />
<variable cmeta:id="INa.Rgas" name="Rgas" public_interface="in" units="joule_per_mole_kelvin" />
<variable cmeta:id="INa.k45" name="k45" units="per_ms" />
<variable cmeta:id="INa.k89" name="k89" units="per_ms" />
<variable cmeta:id="INa.k43" name="k43" units="per_ms" />
<variable cmeta:id="INa.k910" name="k910" units="per_ms" />
<variable cmeta:id="INa.DeltaDelta" name="DeltaDelta" units="per_ms" />
<variable cmeta:id="INa.k512" name="k512" units="per_ms" />
<variable cmeta:id="INa.k114" name="k114" units="per_ms" />
<variable cmeta:id="INa.alpha1" name="alpha1" units="per_ms" />
<variable cmeta:id="INa.k310" name="k310" units="per_ms" />
<variable cmeta:id="INa.k92" name="k92" units="per_ms" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>FoverRT</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<ci>RToverF</ci>
</apply>
</apply>
<apply>
<eq />
<ci>KToverH</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_kelvin" type="e-notation">
1.381
<sep />
-23
</cn>
<ci>TNa</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_ms" type="e-notation">
6.626
<sep />
-31
</cn>
</apply>
</apply>
<apply>
<eq />
<ci>RTNa</ci>
<apply>
<times />
<ci>Rgas</ci>
<ci>TNa</ci>
</apply>
</apply>
<apply>
<eq />
<ci>RTNaF</ci>
<apply>
<divide />
<apply>
<times />
<ci>Rgas</ci>
<ci>TNa</ci>
</apply>
<ci>Faraday</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Temp_Scale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1.38862291252871</cn>
</apply>
<apply>
<eq />
<ci>alpha1</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">114007.462700232</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">224.114</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.286374268596235</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta1</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">272470.273489681</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">708.146</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2.28528417586424</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>gamma1</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">196336.575735923</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">529.952</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2.78084918596045</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Delta1</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">133689.9304091</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">229.205</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1.55804214553883</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>On</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">62123.0784380481</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">39.295</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.288816042743232</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Of</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">97657.8497137015</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">1.51</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.0684861993100685</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>GammaGamma</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">116431.142142348</cn>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">578.317</cn>
</apply>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.764126011745707</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>DeltaDelta</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">55700.6624658307</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">130.639</cn>
</apply>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3.64981672927078</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>epsilon</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">85800.3675578326</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">70.078</cn>
<ci>Rgas</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>omega_na</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">121955.166154864</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">225.175</cn>
<ci>Rgas</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>rho</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">147813.990005035</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">338.915</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2.1360043702126</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>mu</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">121322.143275242</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">193.265</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1.74290267020903</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Cn</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">287913.446530953</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">786.217</cn>
<ci>Rgas</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Cf</ci>
<apply>
<times />
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp />
<apply>
<plus />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole">59565.2236284584</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="joule_per_mole_kelvin">0.00711</cn>
<ci>Rgas</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>parameter_a</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1.40042625477401</cn>
</apply>
<apply>
<eq />
<ci>k12</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>alpha1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k23</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>alpha1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k34</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>alpha1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k45</ci>
<ci>alpha1</ci>
</apply>
<apply>
<eq />
<ci>k56</ci>
<ci>gamma1</ci>
</apply>
<apply>
<eq />
<ci>k67</ci>
<ci>epsilon</ci>
</apply>
<apply>
<eq />
<ci>k89</ci>
<apply>
<times />
<ci>k12</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k910</ci>
<apply>
<times />
<ci>k23</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k1011</ci>
<apply>
<times />
<ci>k34</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k1112</ci>
<apply>
<times />
<ci>k45</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k1213</ci>
<ci>GammaGamma</ci>
</apply>
<apply>
<eq />
<ci>k57</ci>
<ci>rho</ci>
</apply>
<apply>
<eq />
<ci>k21</ci>
<ci>beta1</ci>
</apply>
<apply>
<eq />
<ci>k32</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>beta1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k43</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>beta1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k54</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>beta1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k65</ci>
<ci>Delta1</ci>
</apply>
<apply>
<eq />
<ci>k76</ci>
<ci>omega_na</ci>
</apply>
<apply>
<eq />
<ci>k98</ci>
<apply>
<divide />
<ci>k21</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k109</ci>
<apply>
<divide />
<ci>k32</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k1110</ci>
<apply>
<divide />
<ci>k43</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k1211</ci>
<apply>
<divide />
<ci>k54</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k1312</ci>
<ci>DeltaDelta</ci>
</apply>
<apply>
<eq />
<ci>k75</ci>
<ci>mu</ci>
</apply>
<apply>
<eq />
<ci>k81</ci>
<ci>Cf</ci>
</apply>
<apply>
<eq />
<ci>k92</ci>
<apply>
<divide />
<ci>k81</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k103</ci>
<apply>
<divide />
<ci>k92</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k114</ci>
<apply>
<divide />
<ci>k103</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k125</ci>
<apply>
<divide />
<ci>k114</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k136</ci>
<ci>Of</ci>
</apply>
<apply>
<eq />
<ci>k18</ci>
<ci>Cn</ci>
</apply>
<apply>
<eq />
<ci>k29</ci>
<apply>
<times />
<ci>k18</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k310</ci>
<apply>
<times />
<ci>k29</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k411</ci>
<apply>
<times />
<ci>k310</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k512</ci>
<apply>
<times />
<ci>k411</ci>
<ci>parameter_a</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k613</ci>
<ci>On</ci>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na1</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<apply>
<minus />
<apply>
<plus />
<ci>k18</ci>
<ci>k12</ci>
</apply>
</apply>
<ci>na1</ci>
</apply>
<apply>
<times />
<ci>k21</ci>
<ci>na2</ci>
</apply>
<apply>
<times />
<ci>k81</ci>
<ci>na8</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na2</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>k12</ci>
<ci>na1</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k21</ci>
<ci>k23</ci>
<ci>k29</ci>
</apply>
<ci>na2</ci>
</apply>
</apply>
<apply>
<times />
<ci>k32</ci>
<ci>na3</ci>
</apply>
<apply>
<times />
<ci>k92</ci>
<ci>na9</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na3</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>k23</ci>
<ci>na2</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k32</ci>
<ci>k34</ci>
<ci>k310</ci>
</apply>
<ci>na3</ci>
</apply>
</apply>
<apply>
<times />
<ci>k43</ci>
<ci>na4</ci>
</apply>
<apply>
<times />
<ci>k103</ci>
<ci>na10</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na4</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>k34</ci>
<ci>na3</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k43</ci>
<ci>k45</ci>
<ci>k411</ci>
</apply>
<ci>na4</ci>
</apply>
</apply>
<apply>
<times />
<ci>k54</ci>
<ci>na5</ci>
</apply>
<apply>
<times />
<ci>k114</ci>
<ci>na11</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na5</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>k45</ci>
<ci>na4</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k54</ci>
<ci>k56</ci>
<ci>k57</ci>
<ci>k512</ci>
</apply>
<ci>na5</ci>
</apply>
</apply>
<apply>
<times />
<ci>k65</ci>
<ci>na6</ci>
</apply>
<apply>
<times />
<ci>k75</ci>
<ci>na7</ci>
</apply>
<apply>
<times />
<ci>k125</ci>
<ci>na12</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na6</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>k56</ci>
<ci>na5</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k65</ci>
<ci>k67</ci>
<ci>k613</ci>
</apply>
<ci>na6</ci>
</apply>
</apply>
<apply>
<times />
<ci>k76</ci>
<ci>na7</ci>
</apply>
<apply>
<times />
<ci>k136</ci>
<ci>na13</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na7</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k57</ci>
<ci>na5</ci>
</apply>
<apply>
<times />
<ci>k67</ci>
<ci>na6</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k75</ci>
<ci>k76</ci>
</apply>
<ci>na7</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na8</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>k18</ci>
<ci>na1</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k81</ci>
<ci>k89</ci>
</apply>
<ci>na8</ci>
</apply>
</apply>
<apply>
<times />
<ci>k98</ci>
<ci>na9</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na9</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k29</ci>
<ci>na2</ci>
</apply>
<apply>
<times />
<ci>k89</ci>
<ci>na8</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k98</ci>
<ci>k92</ci>
<ci>k910</ci>
</apply>
<ci>na9</ci>
</apply>
</apply>
<apply>
<times />
<ci>k109</ci>
<ci>na10</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na10</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k310</ci>
<ci>na3</ci>
</apply>
<apply>
<times />
<ci>k910</ci>
<ci>na9</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k1011</ci>
<ci>k103</ci>
<ci>k109</ci>
</apply>
<ci>na10</ci>
</apply>
</apply>
<apply>
<times />
<ci>k1110</ci>
<ci>na11</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na11</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k411</ci>
<ci>na4</ci>
</apply>
<apply>
<times />
<ci>k1011</ci>
<ci>na10</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k1110</ci>
<ci>k114</ci>
<ci>k1112</ci>
</apply>
<ci>na11</ci>
</apply>
</apply>
<apply>
<times />
<ci>k1211</ci>
<ci>na12</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na12</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k512</ci>
<ci>na5</ci>
</apply>
<apply>
<times />
<ci>k1112</ci>
<ci>na11</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k1211</ci>
<ci>k125</ci>
<ci>k1213</ci>
</apply>
<ci>na12</ci>
</apply>
</apply>
<apply>
<times />
<ci>k1312</ci>
<ci>na13</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>na13</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k613</ci>
<ci>na6</ci>
</apply>
<apply>
<times />
<ci>k1213</ci>
<ci>na12</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k1312</ci>
<ci>k136</ci>
</apply>
<ci>na13</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_INaK_INaCa_ICab_IpCa">
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.GCab" initial_value="7.684e-5" name="GCab" units="mS_per_uF" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_ICab" name="ICab" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.KmCa" initial_value="1.38" name="KmCa" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.Nai" name="Nai" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a3_ncx" name="a3_ncx" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.Cao" name="Cao" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_IpCa" name="IpCa" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a2_ncx" name="a2_ncx" units="mM4" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.Cai" name="Cai" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.kNaCa" initial_value="0.44" name="kNaCa" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.ksat" initial_value="0.2" name="ksat" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaCa" name="INaCa" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.IpCamax" initial_value="0.05" name="IpCamax" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.eta" initial_value="0.35" name="eta" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.Ko" name="Ko" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a2_Na" name="a2_Na" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaK" name="INaK" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a5_ncx" name="a5_ncx" units="mM3" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.KmNai" initial_value="20" name="KmNai" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.fNaK" name="fNaK" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.KmpCa" initial_value="0.0005" name="KmpCa" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.INaKmax" initial_value="2.387" name="INaKmax" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a1_Na" name="a1_Na" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a4_ncx" name="a4_ncx" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.ECa" name="ECa" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.VF_over_RT" name="VF_over_RT" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a2_K" name="a2_K" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.KmNa" initial_value="87.5" name="KmNa" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.RT_over_F" name="RT_over_F" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a1_K" name="a1_K" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.a1_ncx" name="a1_ncx" units="mM4" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.KmKo" initial_value="1.5" name="KmKo" units="mM" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.sigma" name="sigma" units="dimensionless" />
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa.Nao" name="Nao" public_interface="in" units="mM" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ICab</ci>
<apply>
<times />
<ci>GCab</ci>
<apply>
<minus />
<ci>V</ci>
<ci>ECa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>IpCa</ci>
<apply>
<divide />
<apply>
<times />
<ci>IpCamax</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus />
<ci>KmpCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>VF_over_RT</ci>
<apply>
<divide />
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq />
<ci>sigma</ci>
<apply>
<divide />
<apply>
<minus />
<apply>
<exp />
<apply>
<divide />
<ci>Nao</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Na</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.1245</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2_Na</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1.33</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>fNaK</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<ci>a1_Na</ci>
<ci>a2_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a1_K</ci>
<apply>
<divide />
<ci>Ko</ci>
<apply>
<plus />
<ci>Ko</ci>
<ci>KmKo</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2_K</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<power />
<apply>
<divide />
<ci>KmNai</ci>
<ci>Nai</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>INaK</ci>
<apply>
<divide />
<apply>
<times />
<ci>INaKmax</ci>
<ci>fNaK</ci>
<ci>a1_K</ci>
</apply>
<ci>a2_K</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_ncx</ci>
<apply>
<times />
<apply>
<exp />
<apply>
<times />
<ci>eta</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<power />
<ci>Nai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_ncx</ci>
<apply>
<times />
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<ci>eta</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<power />
<ci>Nao</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a3_ncx</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<ci>ksat</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<ci>eta</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a4_ncx</ci>
<apply>
<plus />
<ci>KmCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a5_ncx</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<power />
<ci>KmNa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power />
<ci>Nao</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">5000</cn>
</apply>
</apply>
<apply>
<eq />
<ci>INaCa</ci>
<apply>
<divide />
<apply>
<times />
<ci>kNaCa</ci>
<apply>
<minus />
<ci>a1_ncx</ci>
<ci>a2_ncx</ci>
</apply>
</apply>
<apply>
<times />
<ci>a4_ncx</ci>
<ci>a3_ncx</ci>
<ci>a5_ncx</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS">
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.HTRPNtot" initial_value="140e-3" name="HTRPNtot" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.EGTAtot" initial_value="0e0" name="EGTAtot" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CMDNtot" initial_value="50e-3" name="CMDNtot" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.dHTRPNCa" name="dHTRPNCa" units="per_ms" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.kltrpn_plus" initial_value="40e0" name="kltrpn_plus" units="per_mM_per_ms" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_Jtrpn" name="Jtrpn" public_interface="out" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.KmEGTA" initial_value="1.5e-4" name="KmEGTA" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.beta_JSR" name="beta_JSR" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.kltrpn_minus" initial_value="40e-3" name="kltrpn_minus" units="per_ms" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.KmCSQN" initial_value="0.8e0" name="KmCSQN" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.KmCMDN" initial_value="2.38e-3" name="KmCMDN" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.beta_SS" name="beta_SS" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.time" name="time" public_interface="in" units="ms" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.HTRPNCa" initial_value="0.9772152481" name="HTRPNCa" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.khtrpn_plus" initial_value="20e0" name="khtrpn_plus" units="per_mM_per_ms" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.dLTRPNCa" name="dLTRPNCa" units="per_ms" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.khtrpn_minus" initial_value="0.066e-3" name="khtrpn_minus" units="per_ms" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.LTRPNtot" initial_value="70e-3" name="LTRPNtot" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.CaJSR" name="CaJSR" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.LTRPNCa" initial_value="0.8046584973e-1" name="LTRPNCa" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CSQNtot" initial_value="15e0" name="CSQNtot" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.Cai" name="Cai" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.CaSS" name="CaSS" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS.beta_i" name="beta_i" public_interface="out" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>dLTRPNCa</ci>
<apply>
<minus />
<apply>
<times />
<ci>kltrpn_plus</ci>
<ci>Cai</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times />
<ci>kltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>dHTRPNCa</ci>
<apply>
<minus />
<apply>
<times />
<ci>khtrpn_plus</ci>
<ci>Cai</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times />
<ci>khtrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>dLTRPNCa</ci>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>dHTRPNCa</ci>
</apply>
<apply>
<eq />
<ci>Jtrpn</ci>
<apply>
<plus />
<apply>
<times />
<ci>LTRPNtot</ci>
<ci>dLTRPNCa</ci>
</apply>
<apply>
<times />
<ci>HTRPNtot</ci>
<ci>dHTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_SS</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>CaSS</ci>
<ci>KmCMDN</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>CaSS</ci>
<ci>KmEGTA</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_JSR</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>CSQNtot</ci>
<ci>KmCSQN</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>CaJSR</ci>
<ci>KmCSQN</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_i</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<apply>
<times />
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>Cai</ci>
<ci>KmCMDN</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>Cai</ci>
<ci>KmEGTA</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IKs">
<variable cmeta:id="IKs.O1ks_O2ks" name="O1ks_O2ks" units="per_ms" />
<variable cmeta:id="IKs.C1ks_O1ks" name="C1ks_O1ks" units="per_ms" />
<variable cmeta:id="IKs.O2ks_O1ks" name="O2ks_O1ks" units="per_ms" />
<variable cmeta:id="IKs.O2ks" initial_value="1.298547822e-5" name="O2ks" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKs.C0ks" initial_value="0.9645606295" name="C0ks" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKs.O1ks" initial_value="2.491710696e-7" name="O1ks" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKs.C0ks_C1ks" name="C0ks_C1ks" units="per_ms" />
<variable cmeta:id="IKs.C1ks" initial_value="0.03542613568" name="C1ks" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKs.C1ks_C0ks" name="C1ks_C0ks" units="per_ms" />
<variable cmeta:id="IKs.time" name="time" public_interface="in" units="ms" />
<variable cmeta:id="IKs.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="IKs.O1ks_C1ks" name="O1ks_C1ks" units="per_ms" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>C0ks_C1ks</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms">0.00795600798004</cn>
</apply>
<apply>
<eq />
<ci>C1ks_O1ks</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms">0.03966720676071</cn>
</apply>
<apply>
<eq />
<ci>O1ks_O2ks</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms">0.00767254363063</cn>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV">0.08662945914655</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>O1ks_C1ks</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms">0.00700806628929</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV">0.14999754700285</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>O2ks_O1ks</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms">0.00379737998368</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV">0.01425668126881</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C1ks_C0ks</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms">0.2162557589585</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_mV">0.00001889123021</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C0ks</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<apply>
<minus />
<ci>C0ks_C1ks</ci>
</apply>
<ci>C0ks</ci>
</apply>
<apply>
<times />
<ci>C1ks_C0ks</ci>
<ci>C1ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C1ks</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>C0ks_C1ks</ci>
<ci>C0ks</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>C1ks_C0ks</ci>
<ci>C1ks_O1ks</ci>
</apply>
<ci>C1ks</ci>
</apply>
</apply>
<apply>
<times />
<ci>O1ks_C1ks</ci>
<ci>O1ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>O1ks</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>C1ks_O1ks</ci>
<ci>C1ks</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>O1ks_C1ks</ci>
<ci>O1ks_O2ks</ci>
</apply>
<ci>O1ks</ci>
</apply>
</apply>
<apply>
<times />
<ci>O2ks_O1ks</ci>
<ci>O2ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>O2ks</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>O1ks_O2ks</ci>
<ci>O1ks</ci>
</apply>
<apply>
<times />
<ci>O2ks_O1ks</ci>
<ci>O2ks</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IKr">
<variable cmeta:id="IKr.C2H_to_C3H" name="C2H_to_C3H" units="per_ms" />
<variable cmeta:id="IKr.C2H_to_C1H" name="C2H_to_C1H" units="per_ms" />
<variable cmeta:id="IKr.OH_to_C3H" name="OH_to_C3H" units="per_ms" />
<variable cmeta:id="IKr.A6_HERG" initial_value="0.00008039374403" name="A6_HERG" units="per_ms" />
<variable cmeta:id="IKr.A0_HERG" initial_value="0.017147641733086" name="A0_HERG" units="per_ms" />
<variable cmeta:id="IKr.C3Herg" initial_value="7.634099755000001e-5" name="C3Herg" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKr.IHerg" initial_value="1.533347007e-6" name="IHerg" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKr.A3_HERG" initial_value="0.00134366604423" name="A3_HERG" units="per_ms" />
<variable cmeta:id="IKr.B1_HERG" initial_value="-0.0430605416398" name="B1_HERG" units="per_mV" />
<variable cmeta:id="IKr.IH_to_OH" name="IH_to_OH" units="per_ms" />
<variable cmeta:id="IKr.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="IKr.A1_HERG" initial_value="0.03969328381141" name="A1_HERG" units="per_ms" />
<variable cmeta:id="IKr.A4_HERG" initial_value="0.10666316491288" name="A4_HERG" units="per_ms" />
<variable cmeta:id="IKr.C2Herg" initial_value="4.340879648e-4" name="C2Herg" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKr.IH_to_C3H" name="IH_to_C3H" units="per_ms" />
<variable cmeta:id="IKr.OHerg" initial_value="9.511789113e-6" name="OHerg" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKr.a2_C2" name="a2_C2" units="per_ms" />
<variable cmeta:id="IKr.a2_C3" name="a2_C3" units="per_ms" />
<variable cmeta:id="IKr.a1_I" name="a1_I" units="per_ms" />
<variable cmeta:id="IKr.a2_I" name="a2_I" units="per_ms" />
<variable cmeta:id="IKr.B5_HERG" initial_value="-0.04536642959543" name="B5_HERG" units="per_mV" />
<variable cmeta:id="IKr.T_Const_HERG" initial_value="5.320000001" name="T_Const_HERG" units="dimensionless" />
<variable cmeta:id="IKr.a1_O" name="a1_O" units="per_ms" />
<variable cmeta:id="IKr.B2_HERG" initial_value="0.02617412715118" name="B2_HERG" units="per_mV" />
<variable cmeta:id="IKr.a2_O" name="a2_O" units="per_ms" />
<variable cmeta:id="IKr.B3_HERG" initial_value="-0.02691385498399" name="B3_HERG" units="per_mV" />
<variable cmeta:id="IKr.B0_HERG" initial_value="0.03304608038835" name="B0_HERG" units="per_mV" />
<variable cmeta:id="IKr.C1Herg" initial_value="0.996697338" name="C1Herg" public_interface="out" units="dimensionless" />
<variable cmeta:id="IKr.C3H_to_OH" name="C3H_to_OH" units="per_ms" />
<variable cmeta:id="IKr.C3H_to_IH" name="C3H_to_IH" units="per_ms" />
<variable cmeta:id="IKr.A2_HERG" initial_value="0.02057448605977" name="A2_HERG" units="per_ms" />
<variable cmeta:id="IKr.C3H_to_C2H" name="C3H_to_C2H" units="per_ms" />
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<variable cmeta:id="IKr.B4_HERG" initial_value="0.00568908859717" name="B4_HERG" units="per_mV" />
<variable cmeta:id="IKr.OH_to_IH" name="OH_to_IH" units="per_ms" />
<variable cmeta:id="IKr.time" name="time" public_interface="in" units="ms" />
<variable cmeta:id="IKr.a1_C3" name="a1_C3" units="per_ms" />
<variable cmeta:id="IKr.a1_C2" name="a1_C2" units="per_ms" />
<variable cmeta:id="IKr.C1H_to_C2H" name="C1H_to_C2H" units="per_ms" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>C2H_to_C3H</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms">0.02608362043337</cn>
</apply>
</apply>
<apply>
<eq />
<ci>C3H_to_C2H</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="per_ms">0.14832978132145</cn>
</apply>
</apply>
<apply>
<eq />
<ci>C1H_to_C2H</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<ci>A0_HERG</ci>
<apply>
<exp />
<apply>
<times />
<ci>B0_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C2H_to_C1H</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<ci>A1_HERG</ci>
<apply>
<exp />
<apply>
<times />
<ci>B1_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C3H_to_OH</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<ci>A2_HERG</ci>
<apply>
<exp />
<apply>
<times />
<ci>B2_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>OH_to_C3H</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<ci>A3_HERG</ci>
<apply>
<exp />
<apply>
<times />
<ci>B3_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>OH_to_IH</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<ci>A4_HERG</ci>
<apply>
<exp />
<apply>
<times />
<ci>B4_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>IH_to_OH</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<ci>A5_HERG</ci>
<apply>
<exp />
<apply>
<times />
<ci>B5_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C3H_to_IH</ci>
<apply>
<times />
<ci>T_Const_HERG</ci>
<ci>A6_HERG</ci>
<apply>
<exp />
<apply>
<times />
<ci>B6_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>IH_to_C3H</ci>
<apply>
<divide />
<apply>
<times />
<ci>OH_to_C3H</ci>
<ci>IH_to_OH</ci>
<ci>C3H_to_IH</ci>
</apply>
<apply>
<times />
<ci>C3H_to_OH</ci>
<ci>OH_to_IH</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Herg</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>C2H_to_C1H</ci>
<ci>C2Herg</ci>
</apply>
<apply>
<times />
<ci>C1H_to_C2H</ci>
<ci>C1Herg</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C2</ci>
<apply>
<plus />
<apply>
<times />
<ci>C1H_to_C2H</ci>
<ci>C1Herg</ci>
</apply>
<apply>
<times />
<ci>C3H_to_C2H</ci>
<ci>C3Herg</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C2</ci>
<apply>
<times />
<apply>
<plus />
<ci>C2H_to_C1H</ci>
<ci>C2H_to_C3H</ci>
</apply>
<ci>C2Herg</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Herg</ci>
</apply>
<apply>
<minus />
<ci>a1_C2</ci>
<ci>a2_C2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C3</ci>
<apply>
<plus />
<apply>
<times />
<ci>C2H_to_C3H</ci>
<ci>C2Herg</ci>
</apply>
<apply>
<times />
<ci>OH_to_C3H</ci>
<ci>OHerg</ci>
</apply>
<apply>
<times />
<ci>IH_to_C3H</ci>
<ci>IHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C3</ci>
<apply>
<times />
<apply>
<plus />
<ci>C3H_to_IH</ci>
<ci>C3H_to_OH</ci>
<ci>C3H_to_C2H</ci>
</apply>
<ci>C3Herg</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Herg</ci>
</apply>
<apply>
<minus />
<ci>a1_C3</ci>
<ci>a2_C3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_O</ci>
<apply>
<plus />
<apply>
<times />
<ci>C3H_to_OH</ci>
<ci>C3Herg</ci>
</apply>
<apply>
<times />
<ci>IH_to_OH</ci>
<ci>IHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2_O</ci>
<apply>
<times />
<apply>
<plus />
<ci>OH_to_C3H</ci>
<ci>OH_to_IH</ci>
</apply>
<ci>OHerg</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>OHerg</ci>
</apply>
<apply>
<minus />
<ci>a1_O</ci>
<ci>a2_O</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_I</ci>
<apply>
<plus />
<apply>
<times />
<ci>C3H_to_IH</ci>
<ci>C3Herg</ci>
</apply>
<apply>
<times />
<ci>OH_to_IH</ci>
<ci>OHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>a2_I</ci>
<apply>
<times />
<apply>
<plus />
<ci>IH_to_C3H</ci>
<ci>IH_to_OH</ci>
</apply>
<ci>IHerg</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>IHerg</ci>
</apply>
<apply>
<minus />
<ci>a1_I</ci>
<ci>a2_I</ci>
</apply>
</apply>
</math>
</component>
<component name="Ions_n_reversal_potentials" />
<component name="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES">
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.alphai0Kv14" initial_value="0.00305767916" name="alphai0Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.OIKv14_to_OKv14" name="OIKv14_to_OKv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.f1Kv14" initial_value="0.52465073996" name="f1Kv14" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.OKv14" initial_value="1.975541357e-5" name="OKv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C0Kv14_to_CI0Kv14" name="C0Kv14_to_CI0Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C2Kv14_to_CI2Kv14" name="C2Kv14_to_CI2Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C1Kv14" initial_value="0.1730990528" name="C1Kv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI2Kv14_to_CI1Kv14" name="CI2Kv14_to_CI1Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.aaKv14" initial_value="0.00768548031" name="aaKv14" units="per_mV" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C2Kv14_to_C3Kv14" name="C2Kv14_to_C3Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C3Kv14_to_C2Kv14" name="C3Kv14_to_C2Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI2Kv14_to_C2Kv14" name="CI2Kv14_to_C2Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C0Kv14" initial_value="0.5977099765" name="C0Kv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C3Kv14_to_OKv14" name="C3Kv14_to_OKv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_OI" name="a1_OI" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.baKv14" initial_value="0.07793378174" name="baKv14" units="per_mV" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.f3Kv14" initial_value="938.58764534556" name="f3Kv14" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C1Kv14_to_C0Kv14" name="C1Kv14_to_C0Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.beta_inact14" name="beta_inact14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.f4Kv14" initial_value="54749.19473332601" name="f4Kv14" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C3Kv14" initial_value="9.16070135e-4" name="C3Kv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.OIKv14_to_CI3Kv14" name="OIKv14_to_CI3Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.f2Kv14" initial_value="17.51885408639" name="f2Kv14" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_C1" name="a1_C1" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_O" name="a2_O" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_C2" name="a1_C2" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_C0" name="a1_C0" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_C3" name="a1_C3" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C0Kv14_to_C1Kv14" name="C0Kv14_to_C1Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C2Kv14" initial_value="0.01881072386" name="C2Kv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.OKv14_to_OIKv14" name="OKv14_to_OIKv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_CI3" name="a1_CI3" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_CI2" name="a1_CI2" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C1Kv14_to_C2Kv14" name="C1Kv14_to_C2Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_OI" name="a2_OI" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI0Kv14_to_C0Kv14" name="CI0Kv14_to_C0Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI3Kv14_to_C3Kv14" name="CI3Kv14_to_C3Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.b2Kv14" initial_value="1.17100540567" name="b2Kv14" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_CI1" name="a1_CI1" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C1Kv14_to_CI1Kv14" name="C1Kv14_to_CI1Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C3Kv14_to_CI3Kv14" name="C3Kv14_to_CI3Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_CI0" name="a1_CI0" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI0Kv14" initial_value="0.03539084346" name="CI0Kv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.b3Kv14" initial_value="0.63902768758" name="b3Kv14" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI1Kv14_to_CI0Kv14" name="CI1Kv14_to_CI0Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI3Kv14_to_CI2Kv14" name="CI3Kv14_to_CI2Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.alphaa0Kv14" initial_value="1.84002414554" name="alphaa0Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.time" name="time" public_interface="in" units="ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_C2" name="a2_C2" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI1Kv14" initial_value="0.005428824353" name="CI1Kv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_C3" name="a2_C3" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_C0" name="a2_C0" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.b1Kv14" initial_value="1.00947847105" name="b1Kv14" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_C1" name="a2_C1" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.beta_act14" name="beta_act14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI3Kv14_to_OIKv14" name="CI3Kv14_to_OIKv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.alpha_inact14" name="alpha_inact14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI2Kv14" initial_value="0.02287858869" name="CI2Kv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI0Kv14_to_CI1Kv14" name="CI0Kv14_to_CI1Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI1Kv14_to_CI2Kv14" name="CI1Kv14_to_CI2Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI2Kv14_to_CI3Kv14" name="CI2Kv14_to_CI3Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.betai0Kv14" initial_value="0.00000244936" name="betai0Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI1Kv14_to_C1Kv14" name="CI1Kv14_to_C1Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.C2Kv14_to_C1Kv14" name="C2Kv14_to_C1Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_CI0" name="a2_CI0" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.OKv14_to_C3Kv14" name="OKv14_to_C3Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.alpha_act14" name="alpha_act14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_CI3" name="a2_CI3" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.betaa0Kv14" initial_value="0.0108174834" name="betaa0Kv14" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_CI2" name="a2_CI2" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.CI3Kv14" initial_value="0.03233800003" name="CI3Kv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.OIKv14" initial_value="0.1134082058" name="OIKv14" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a2_CI1" name="a2_CI1" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.a1_O" name="a1_O" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES.b4Kv14" initial_value="2.12035379095" name="b4Kv14" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>alpha_act14</ci>
<apply>
<times />
<ci>alphaa0Kv14</ci>
<apply>
<exp />
<apply>
<times />
<ci>aaKv14</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta_act14</ci>
<apply>
<times />
<ci>betaa0Kv14</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<ci>baKv14</ci>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>alpha_inact14</ci>
<ci>alphai0Kv14</ci>
</apply>
<apply>
<eq />
<ci>beta_inact14</ci>
<ci>betai0Kv14</ci>
</apply>
<apply>
<eq />
<ci>C0Kv14_to_C1Kv14</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>alpha_act14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C1Kv14_to_C2Kv14</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>alpha_act14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C2Kv14_to_C3Kv14</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>alpha_act14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3Kv14_to_OKv14</ci>
<ci>alpha_act14</ci>
</apply>
<apply>
<eq />
<ci>CI0Kv14_to_CI1Kv14</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>b1Kv14</ci>
<ci>alpha_act14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI1Kv14_to_CI2Kv14</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>b2Kv14</ci>
<ci>alpha_act14</ci>
</apply>
<ci>b1Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI2Kv14_to_CI3Kv14</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>b3Kv14</ci>
<ci>alpha_act14</ci>
</apply>
<ci>b2Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI3Kv14_to_OIKv14</ci>
<apply>
<divide />
<apply>
<times />
<ci>b4Kv14</ci>
<ci>alpha_act14</ci>
</apply>
<ci>b3Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C1Kv14_to_C0Kv14</ci>
<ci>beta_act14</ci>
</apply>
<apply>
<eq />
<ci>C2Kv14_to_C1Kv14</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>beta_act14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3Kv14_to_C2Kv14</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>beta_act14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>OKv14_to_C3Kv14</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>beta_act14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI1Kv14_to_CI0Kv14</ci>
<apply>
<divide />
<ci>beta_act14</ci>
<ci>f1Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI2Kv14_to_CI1Kv14</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>f1Kv14</ci>
<ci>beta_act14</ci>
</apply>
<ci>f2Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI3Kv14_to_CI2Kv14</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>f2Kv14</ci>
<ci>beta_act14</ci>
</apply>
<ci>f3Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>OIKv14_to_CI3Kv14</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>f3Kv14</ci>
<ci>beta_act14</ci>
</apply>
<ci>f4Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C0Kv14_to_CI0Kv14</ci>
<ci>beta_inact14</ci>
</apply>
<apply>
<eq />
<ci>C1Kv14_to_CI1Kv14</ci>
<apply>
<times />
<ci>f1Kv14</ci>
<ci>beta_inact14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C2Kv14_to_CI2Kv14</ci>
<apply>
<times />
<ci>f2Kv14</ci>
<ci>beta_inact14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3Kv14_to_CI3Kv14</ci>
<apply>
<times />
<ci>f3Kv14</ci>
<ci>beta_inact14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>OKv14_to_OIKv14</ci>
<apply>
<times />
<ci>f4Kv14</ci>
<ci>beta_inact14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI0Kv14_to_C0Kv14</ci>
<ci>alpha_inact14</ci>
</apply>
<apply>
<eq />
<ci>CI1Kv14_to_C1Kv14</ci>
<apply>
<divide />
<ci>alpha_inact14</ci>
<ci>b1Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI2Kv14_to_C2Kv14</ci>
<apply>
<divide />
<ci>alpha_inact14</ci>
<ci>b2Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI3Kv14_to_C3Kv14</ci>
<apply>
<divide />
<ci>alpha_inact14</ci>
<ci>b3Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>OIKv14_to_OKv14</ci>
<apply>
<divide />
<ci>alpha_inact14</ci>
<ci>b4Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C0</ci>
<apply>
<times />
<apply>
<plus />
<ci>C0Kv14_to_C1Kv14</ci>
<ci>C0Kv14_to_CI0Kv14</ci>
</apply>
<ci>C0Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C0</ci>
<apply>
<plus />
<apply>
<times />
<ci>C1Kv14_to_C0Kv14</ci>
<ci>C1Kv14</ci>
</apply>
<apply>
<times />
<ci>CI0Kv14_to_C0Kv14</ci>
<ci>CI0Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Kv14</ci>
</apply>
<apply>
<minus />
<ci>a2_C0</ci>
<ci>a1_C0</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C1</ci>
<apply>
<times />
<apply>
<plus />
<ci>C1Kv14_to_C2Kv14</ci>
<ci>C1Kv14_to_C0Kv14</ci>
<ci>C1Kv14_to_CI1Kv14</ci>
</apply>
<ci>C1Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C1</ci>
<apply>
<plus />
<apply>
<times />
<ci>C2Kv14_to_C1Kv14</ci>
<ci>C2Kv14</ci>
</apply>
<apply>
<times />
<ci>CI1Kv14_to_C1Kv14</ci>
<ci>CI1Kv14</ci>
</apply>
<apply>
<times />
<ci>C0Kv14_to_C1Kv14</ci>
<ci>C0Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kv14</ci>
</apply>
<apply>
<minus />
<ci>a2_C1</ci>
<ci>a1_C1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C2</ci>
<apply>
<times />
<apply>
<plus />
<ci>C2Kv14_to_C3Kv14</ci>
<ci>C2Kv14_to_C1Kv14</ci>
<ci>C2Kv14_to_CI2Kv14</ci>
</apply>
<ci>C2Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C2</ci>
<apply>
<plus />
<apply>
<times />
<ci>C3Kv14_to_C2Kv14</ci>
<ci>C3Kv14</ci>
</apply>
<apply>
<times />
<ci>CI2Kv14_to_C2Kv14</ci>
<ci>CI2Kv14</ci>
</apply>
<apply>
<times />
<ci>C1Kv14_to_C2Kv14</ci>
<ci>C1Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kv14</ci>
</apply>
<apply>
<minus />
<ci>a2_C2</ci>
<ci>a1_C2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C3</ci>
<apply>
<times />
<apply>
<plus />
<ci>C3Kv14_to_OKv14</ci>
<ci>C3Kv14_to_C2Kv14</ci>
<ci>C3Kv14_to_CI3Kv14</ci>
</apply>
<ci>C3Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C3</ci>
<apply>
<plus />
<apply>
<times />
<ci>OKv14_to_C3Kv14</ci>
<ci>OKv14</ci>
</apply>
<apply>
<times />
<ci>CI3Kv14_to_C3Kv14</ci>
<ci>CI3Kv14</ci>
</apply>
<apply>
<times />
<ci>C2Kv14_to_C3Kv14</ci>
<ci>C2Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Kv14</ci>
</apply>
<apply>
<minus />
<ci>a2_C3</ci>
<ci>a1_C3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_O</ci>
<apply>
<times />
<apply>
<plus />
<ci>OKv14_to_C3Kv14</ci>
<ci>OKv14_to_OIKv14</ci>
</apply>
<ci>OKv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_O</ci>
<apply>
<plus />
<apply>
<times />
<ci>C3Kv14_to_OKv14</ci>
<ci>C3Kv14</ci>
</apply>
<apply>
<times />
<ci>OIKv14_to_OKv14</ci>
<ci>OIKv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>OKv14</ci>
</apply>
<apply>
<minus />
<ci>a2_O</ci>
<ci>a1_O</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_CI0</ci>
<apply>
<times />
<apply>
<plus />
<ci>CI0Kv14_to_C0Kv14</ci>
<ci>CI0Kv14_to_CI1Kv14</ci>
</apply>
<ci>CI0Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_CI0</ci>
<apply>
<plus />
<apply>
<times />
<ci>C0Kv14_to_CI0Kv14</ci>
<ci>C0Kv14</ci>
</apply>
<apply>
<times />
<ci>CI1Kv14_to_CI0Kv14</ci>
<ci>CI1Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CI0Kv14</ci>
</apply>
<apply>
<minus />
<ci>a2_CI0</ci>
<ci>a1_CI0</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_CI1</ci>
<apply>
<times />
<apply>
<plus />
<ci>CI1Kv14_to_CI2Kv14</ci>
<ci>CI1Kv14_to_C1Kv14</ci>
<ci>CI1Kv14_to_CI0Kv14</ci>
</apply>
<ci>CI1Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_CI1</ci>
<apply>
<plus />
<apply>
<times />
<ci>CI2Kv14_to_CI1Kv14</ci>
<ci>CI2Kv14</ci>
</apply>
<apply>
<times />
<ci>C1Kv14_to_CI1Kv14</ci>
<ci>C1Kv14</ci>
</apply>
<apply>
<times />
<ci>CI0Kv14_to_CI1Kv14</ci>
<ci>CI0Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Kv14</ci>
</apply>
<apply>
<minus />
<ci>a2_CI1</ci>
<ci>a1_CI1</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_CI2</ci>
<apply>
<times />
<apply>
<plus />
<ci>CI2Kv14_to_CI3Kv14</ci>
<ci>CI2Kv14_to_C2Kv14</ci>
<ci>CI2Kv14_to_CI1Kv14</ci>
</apply>
<ci>CI2Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_CI2</ci>
<apply>
<plus />
<apply>
<times />
<ci>CI3Kv14_to_CI2Kv14</ci>
<ci>CI3Kv14</ci>
</apply>
<apply>
<times />
<ci>C2Kv14_to_CI2Kv14</ci>
<ci>C2Kv14</ci>
</apply>
<apply>
<times />
<ci>CI1Kv14_to_CI2Kv14</ci>
<ci>CI1Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Kv14</ci>
</apply>
<apply>
<minus />
<ci>a2_CI2</ci>
<ci>a1_CI2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_CI3</ci>
<apply>
<times />
<apply>
<plus />
<ci>CI3Kv14_to_OIKv14</ci>
<ci>CI3Kv14_to_C3Kv14</ci>
<ci>CI3Kv14_to_CI2Kv14</ci>
</apply>
<ci>CI3Kv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_CI3</ci>
<apply>
<plus />
<apply>
<times />
<ci>OIKv14_to_CI3Kv14</ci>
<ci>OIKv14</ci>
</apply>
<apply>
<times />
<ci>C3Kv14_to_CI3Kv14</ci>
<ci>C3Kv14</ci>
</apply>
<apply>
<times />
<ci>CI2Kv14_to_CI3Kv14</ci>
<ci>CI2Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Kv14</ci>
</apply>
<apply>
<minus />
<ci>a2_CI3</ci>
<ci>a1_CI3</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_OI</ci>
<apply>
<times />
<apply>
<plus />
<ci>OIKv14_to_OKv14</ci>
<ci>OIKv14_to_CI3Kv14</ci>
</apply>
<ci>OIKv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_OI</ci>
<apply>
<plus />
<apply>
<times />
<ci>OKv14_to_OIKv14</ci>
<ci>OKv14</ci>
</apply>
<apply>
<times />
<ci>CI3Kv14_to_OIKv14</ci>
<ci>CI3Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>OIKv14</ci>
</apply>
<apply>
<minus />
<ci>a2_OI</ci>
<ci>a1_OI</ci>
</apply>
</apply>
</math>
</component>
<component name="intracellular_currents" />
<component name="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES">
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.CaSS" name="CaSS" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.kaplus" initial_value="0.01215" name="kaplus" units="per_uM4_per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.dC2_RyR" name="dC2_RyR" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.kcminus" initial_value="0.0008" name="kcminus" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.ncoop" initial_value="4" name="ncoop" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.kaminus" initial_value="0.576" name="kaminus" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.O1_RyR" initial_value="0.6601783287e-3" name="O1_RyR" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.C2_RyR" initial_value="0.554535924" name="C2_RyR" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.dO1_RyR" name="dO1_RyR" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.kbplus" initial_value="0.00405" name="kbplus" units="per_uM3_per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.C1_RyR" initial_value="0.4448038946" name="C1_RyR" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.time" name="time" public_interface="in" units="ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.dC1_RyR" name="dC1_RyR" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.kcplus" initial_value="0.1" name="kcplus" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.mcoop" initial_value="3" name="mcoop" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.O2_RyR" initial_value="0.397392006e-8" name="O2_RyR" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.kbminus" initial_value="1.93" name="kbminus" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES.dO2_RyR" name="dO2_RyR" units="per_ms" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>dC1_RyR</ci>
<apply>
<plus />
<apply>
<times />
<apply>
<minus />
<ci>kaplus</ci>
</apply>
<apply>
<power />
<apply>
<times />
<ci>CaSS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="m2u">1000</cn>
</apply>
<ci>ncoop</ci>
</apply>
<ci>C1_RyR</ci>
</apply>
<apply>
<times />
<ci>kaminus</ci>
<ci>O1_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>dO2_RyR</ci>
<apply>
<minus />
<apply>
<times />
<ci>kbplus</ci>
<apply>
<power />
<apply>
<times />
<ci>CaSS</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="m2u">1000</cn>
</apply>
<ci>mcoop</ci>
</apply>
<ci>O1_RyR</ci>
</apply>
<apply>
<times />
<ci>kbminus</ci>
<ci>O2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>dC2_RyR</ci>
<apply>
<minus />
<apply>
<times />
<ci>kcplus</ci>
<ci>O1_RyR</ci>
</apply>
<apply>
<times />
<ci>kcminus</ci>
<ci>C2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>dO1_RyR</ci>
<apply>
<minus />
<apply>
<plus />
<ci>dC1_RyR</ci>
<ci>dO2_RyR</ci>
<ci>dC2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C1_RyR</ci>
</apply>
<ci>dC1_RyR</ci>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>O2_RyR</ci>
</apply>
<ci>dO2_RyR</ci>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C2_RyR</ci>
</apply>
<ci>dC2_RyR</ci>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>O1_RyR</ci>
</apply>
<ci>dO1_RyR</ci>
</apply>
</math>
</component>
<component name="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp">
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.Faraday" name="Faraday" public_interface="in" units="coulomb_per_millimole" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.Kv43Frac" initial_value="0.889" name="Kv43Frac" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.IKv14" name="IKv14" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.GKr" initial_value="0.0186e0" name="GKr" units="mS_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.GK1" initial_value="0.1253051261188079722568586886469e0" name="GK1" units="mS_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.a1_Na" name="a1_Na" units="mM" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKr" name="IKr" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.GKs" initial_value="0.0035e0" name="GKs" units="mS_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IK1" name="IK1" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.IKv14_Na" name="IKv14_Na" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKs" name="IKs" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.EK" name="EK" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.VF_over_RT" name="VF_over_RT" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.K1_inf" name="K1_inf" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.Nao" name="Nao" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.IKv43" name="IKv43" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.OKv14" name="OKv14" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.fKo" name="fKo" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.Ki" name="Ki" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.a1_K" name="a1_K" units="mM" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_Ito1" name="Ito1" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.Ko" name="Ko" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.RT_over_F" name="RT_over_F" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.O1ks" name="O1ks" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.Nai" name="Nai" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.IKv14_K" name="IKv14_K" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.O2ks" name="O2ks" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.PKv14" name="PKv14" units="litre_per_farad_second" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.ENa" name="ENa" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.KvScale" initial_value="0.872" name="KvScale" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.GNa" initial_value="56.32e0" name="GNa" units="mS_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.OHerg" name="OHerg" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.GKv43" name="GKv43" units="mS_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INa" name="INa" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.GNab" initial_value="0.001e0" name="GNab" units="mS_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INab" name="INab" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.OKv43" name="OKv43" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.a2" name="a2" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.VFsq_over_RT" name="VFsq_over_RT" units="coulomb_per_millimole" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.na6" name="na6" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp.na7" name="na7" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>PKv14</ci>
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<ci>Kv43Frac</ci>
</apply>
<ci>KvScale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="litre_per_farad_second" type="e-notation">
4.2986
<sep />
-7
</cn>
</apply>
</apply>
<apply>
<eq />
<ci>GKv43</ci>
<apply>
<times />
<ci>Kv43Frac</ci>
<ci>KvScale</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mS_per_uF">0.1</cn>
</apply>
</apply>
<apply>
<eq />
<ci>INa</ci>
<apply>
<times />
<ci>GNa</ci>
<apply>
<plus />
<ci>na6</ci>
<ci>na7</ci>
</apply>
<apply>
<minus />
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>fKo</ci>
<apply>
<root />
<apply>
<divide />
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">4</cn>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>IKr</ci>
<apply>
<times />
<ci>GKr</ci>
<ci>fKo</ci>
<ci>OHerg</ci>
<apply>
<minus />
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>IKs</ci>
<apply>
<times />
<ci>GKs</ci>
<apply>
<plus />
<ci>O1ks</ci>
<ci>O2ks</ci>
</apply>
<apply>
<minus />
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>IKv43</ci>
<apply>
<times />
<ci>GKv43</ci>
<ci>OKv43</ci>
<apply>
<minus />
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>VF_over_RT</ci>
<apply>
<divide />
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq />
<ci>VFsq_over_RT</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1000</cn>
<ci>Faraday</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_K</ci>
<apply>
<minus />
<apply>
<times />
<ci>Ki</ci>
<apply>
<exp />
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2</ci>
<apply>
<minus />
<apply>
<exp />
<ci>VF_over_RT</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq />
<ci>IKv14_K</ci>
<apply>
<divide />
<apply>
<times />
<ci>PKv14</ci>
<ci>OKv14</ci>
<ci>VFsq_over_RT</ci>
<ci>a1_K</ci>
</apply>
<ci>a2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_Na</ci>
<apply>
<minus />
<apply>
<times />
<ci>Nai</ci>
<apply>
<exp />
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<eq />
<ci>IKv14_Na</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.02</cn>
<ci>PKv14</ci>
<ci>OKv14</ci>
<ci>VFsq_over_RT</ci>
<ci>a1_Na</ci>
</apply>
<ci>a2</ci>
</apply>
</apply>
<apply>
<eq />
<ci>IKv14</ci>
<apply>
<plus />
<ci>IKv14_K</ci>
<ci>IKv14_Na</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Ito1</ci>
<apply>
<plus />
<ci>IKv43</ci>
<ci>IKv14</ci>
</apply>
</apply>
<apply>
<eq />
<ci>K1_inf</ci>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.94</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1.26</cn>
<ci>RT_over_F</ci>
</apply>
<apply>
<minus />
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>IK1</ci>
<apply>
<times />
<ci>GK1</ci>
<apply>
<root />
<apply>
<divide />
<ci>Ko</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">1</cn>
</apply>
</apply>
<ci>K1_inf</ci>
<apply>
<minus />
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>INab</ci>
<apply>
<times />
<ci>GNab</ci>
<apply>
<minus />
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transmembrane_currents" />
<component name="I_stimulus">
<variable cmeta:id="I_stimulus.past" name="past" units="ms" />
<variable cmeta:id="I_stimulus.stim_offset" initial_value="0" name="stim_offset" units="ms" />
<variable cmeta:id="I_stimulus.stim_amplitude" initial_value="-15" name="stim_amplitude" units="uA_per_uF" />
<variable cmeta:id="I_stimulus.stim_period" initial_value="1e3" name="stim_period" units="ms" />
<variable cmeta:id="I_stimulus.i_Stim" name="i_Stim" public_interface="out" units="uA_per_uF" />
<variable cmeta:id="I_stimulus.stim_duration" initial_value="3" name="stim_duration" units="ms" />
<variable cmeta:id="I_stimulus.time" name="time" public_interface="in" units="ms" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>past</ci>
<apply>
<times />
<apply>
<floor />
<apply>
<divide />
<ci>time</ci>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<apply>
<eq />
<ci>i_Stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and />
<apply>
<geq />
<apply>
<minus />
<ci>time</ci>
<ci>past</ci>
</apply>
<ci>stim_offset</ci>
</apply>
<apply>
<leq />
<apply>
<minus />
<ci>time</ci>
<ci>past</ci>
</apply>
<apply>
<plus />
<ci>stim_offset</ci>
<ci>stim_duration</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="uA_per_uF">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="ms" />
</component>
<component name="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES">
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_C043" name="a2_C043" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_C243" name="a2_C243" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C0Kv43_to_CI0Kv43" name="C0Kv43_to_CI0Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C2Kv43_to_CI2Kv43" name="C2Kv43_to_CI2Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI1Kv43_to_C1Kv43" name="CI1Kv43_to_C1Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI1Kv43_to_CI0Kv43" name="CI1Kv43_to_CI0Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI3Kv43_to_CI2Kv43" name="CI3Kv43_to_CI2Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI3Kv43_to_OIKv43" name="CI3Kv43_to_OIKv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI0Kv43" initial_value="0.01513025204" name="CI0Kv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.b3Kv43" initial_value="28.7532603313" name="b3Kv43" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.OIKv43_to_CI3Kv43" name="OIKv43_to_CI3Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_I343" name="a1_I343" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.alpha_inact43" name="alpha_inact43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C1Kv43_to_C0Kv43" name="C1Kv43_to_C0Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_I143" name="a1_I143" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.b1Kv43" initial_value="6.77348" name="b1Kv43" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.time" name="time" public_interface="in" units="ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_O43" name="a2_O43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C0Kv43_to_C1Kv43" name="C0Kv43_to_C1Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.b2Kv43" initial_value="15.6212705152" name="b2Kv43" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.OKv43" initial_value="2.29955624e-9" name="OKv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.f3Kv43" initial_value="158.574378389" name="f3Kv43" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI3Kv43" initial_value="9.514386057000001e-5" name="CI3Kv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C3Kv43" initial_value="1.311837579e-6" name="C3Kv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI0Kv43_to_C0Kv43" name="CI0Kv43_to_C0Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI0Kv43_to_CI1Kv43" name="CI0Kv43_to_CI1Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI1Kv43_to_CI2Kv43" name="CI1Kv43_to_CI2Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI2Kv43_to_CI3Kv43" name="CI2Kv43_to_CI3Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.OIKv43_to_OKv43" name="OIKv43_to_OKv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.baKv43" initial_value="0.0468437" name="baKv43" units="per_mV" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_C143" name="a1_C143" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.beta_inact43" name="beta_inact43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.betai0Kv43" initial_value="0.000819482" name="betai0Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.f2Kv43" initial_value="14.224647456" name="f2Kv43" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI3Kv43_to_C3Kv43" name="CI3Kv43_to_C3Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.betaa0Kv43" initial_value="0.080185" name="betaa0Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_C343" name="a1_C343" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.f4Kv43" initial_value="142.936645351" name="f4Kv43" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI2Kv43" initial_value="9.918373359000001e-4" name="CI2Kv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C1Kv43_to_C2Kv43" name="C1Kv43_to_C2Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C3Kv43_to_OKv43" name="C3Kv43_to_OKv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C2Kv43" initial_value="2.806380358e-4" name="C2Kv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI1Kv43" initial_value="0.005442964601" name="CI1Kv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_I343" name="a2_I343" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_OI43" name="a1_OI43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_I143" name="a2_I143" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_C143" name="a2_C143" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C1Kv43_to_CI1Kv43" name="C1Kv43_to_CI1Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C3Kv43_to_CI3Kv43" name="C3Kv43_to_CI3Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.OKv43_to_OIKv43" name="OKv43_to_OIKv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_C343" name="a2_C343" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C2Kv43_to_C1Kv43" name="C2Kv43_to_C1Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI2Kv43_to_CI1Kv43" name="CI2Kv43_to_CI1Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_OI43" name="a2_OI43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C1Kv43" initial_value="0.02668288089" name="C1Kv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.aiKv43" initial_value="0.000373016" name="aiKv43" units="per_mV" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_I243" name="a1_I243" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_I043" name="a1_I043" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.aaKv43" initial_value="0.028983" name="aaKv43" units="per_mV" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.alphaa0Kv43" initial_value="0.543708" name="alphaa0Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.beta_act43" name="beta_act43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.f1Kv43" initial_value="1.8936" name="f1Kv43" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.biKv43" initial_value="0.00000005374" name="biKv43" units="per_mV" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C0Kv43" initial_value="0.9513721351" name="C0Kv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.CI2Kv43_to_C2Kv43" name="CI2Kv43_to_C2Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C3Kv43_to_C2Kv43" name="C3Kv43_to_C2Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.OKv43_to_C3Kv43" name="OKv43_to_C3Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.alphai0Kv43" initial_value="0.0498424" name="alphai0Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_C043" name="a1_C043" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.alpha_act43" name="alpha_act43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_O43" name="a1_O43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a1_C243" name="a1_C243" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.C2Kv43_to_C3Kv43" name="C2Kv43_to_C3Kv43" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_I043" name="a2_I043" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.OIKv43" initial_value="2.742677382e-6" name="OIKv43" public_interface="out" units="dimensionless" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.a2_I243" name="a2_I243" units="per_ms" />
<variable cmeta:id="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES.b4Kv43" initial_value="524.576206679" name="b4Kv43" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>alpha_act43</ci>
<apply>
<times />
<ci>alphaa0Kv43</ci>
<apply>
<exp />
<apply>
<times />
<ci>aaKv43</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
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<apply>
<eq />
<ci>beta_act43</ci>
<apply>
<times />
<ci>betaa0Kv43</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<ci>baKv43</ci>
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<ci>V</ci>
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<apply>
<eq />
<ci>alpha_inact43</ci>
<apply>
<times />
<ci>alphai0Kv43</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<ci>aiKv43</ci>
</apply>
<ci>V</ci>
</apply>
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<apply>
<eq />
<ci>beta_inact43</ci>
<apply>
<times />
<ci>betai0Kv43</ci>
<apply>
<exp />
<apply>
<times />
<ci>biKv43</ci>
<ci>V</ci>
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</apply>
</apply>
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<apply>
<eq />
<ci>C0Kv43_to_C1Kv43</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>alpha_act43</ci>
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<apply>
<eq />
<ci>C1Kv43_to_C2Kv43</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>alpha_act43</ci>
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<apply>
<eq />
<ci>C2Kv43_to_C3Kv43</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>alpha_act43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3Kv43_to_OKv43</ci>
<ci>alpha_act43</ci>
</apply>
<apply>
<eq />
<ci>CI0Kv43_to_CI1Kv43</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>b1Kv43</ci>
<ci>alpha_act43</ci>
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<apply>
<eq />
<ci>CI1Kv43_to_CI2Kv43</ci>
<apply>
<divide />
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<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>b2Kv43</ci>
<ci>alpha_act43</ci>
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<ci>b1Kv43</ci>
</apply>
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<apply>
<eq />
<ci>CI2Kv43_to_CI3Kv43</ci>
<apply>
<divide />
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<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>b3Kv43</ci>
<ci>alpha_act43</ci>
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<ci>b2Kv43</ci>
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<eq />
<ci>CI3Kv43_to_OIKv43</ci>
<apply>
<divide />
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<times />
<ci>b4Kv43</ci>
<ci>alpha_act43</ci>
</apply>
<ci>b3Kv43</ci>
</apply>
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<apply>
<eq />
<ci>C1Kv43_to_C0Kv43</ci>
<ci>beta_act43</ci>
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<apply>
<eq />
<ci>C2Kv43_to_C1Kv43</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>beta_act43</ci>
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<eq />
<ci>C3Kv43_to_C2Kv43</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>beta_act43</ci>
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<apply>
<eq />
<ci>OKv43_to_C3Kv43</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>beta_act43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI1Kv43_to_CI0Kv43</ci>
<apply>
<divide />
<ci>beta_act43</ci>
<ci>f1Kv43</ci>
</apply>
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<apply>
<eq />
<ci>CI2Kv43_to_CI1Kv43</ci>
<apply>
<divide />
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<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
<ci>f1Kv43</ci>
<ci>beta_act43</ci>
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<ci>f2Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI3Kv43_to_CI2Kv43</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
<ci>f2Kv43</ci>
<ci>beta_act43</ci>
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<ci>f3Kv43</ci>
</apply>
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<apply>
<eq />
<ci>OIKv43_to_CI3Kv43</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">4</cn>
<ci>f3Kv43</ci>
<ci>beta_act43</ci>
</apply>
<ci>f4Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C0Kv43_to_CI0Kv43</ci>
<ci>beta_inact43</ci>
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<apply>
<eq />
<ci>C1Kv43_to_CI1Kv43</ci>
<apply>
<times />
<ci>f1Kv43</ci>
<ci>beta_inact43</ci>
</apply>
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<apply>
<eq />
<ci>C2Kv43_to_CI2Kv43</ci>
<apply>
<times />
<ci>f2Kv43</ci>
<ci>beta_inact43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3Kv43_to_CI3Kv43</ci>
<apply>
<times />
<ci>f3Kv43</ci>
<ci>beta_inact43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>OKv43_to_OIKv43</ci>
<apply>
<times />
<ci>f4Kv43</ci>
<ci>beta_inact43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI0Kv43_to_C0Kv43</ci>
<ci>alpha_inact43</ci>
</apply>
<apply>
<eq />
<ci>CI1Kv43_to_C1Kv43</ci>
<apply>
<divide />
<ci>alpha_inact43</ci>
<ci>b1Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI2Kv43_to_C2Kv43</ci>
<apply>
<divide />
<ci>alpha_inact43</ci>
<ci>b2Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>CI3Kv43_to_C3Kv43</ci>
<apply>
<divide />
<ci>alpha_inact43</ci>
<ci>b3Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>OIKv43_to_OKv43</ci>
<apply>
<divide />
<ci>alpha_inact43</ci>
<ci>b4Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C043</ci>
<apply>
<times />
<apply>
<plus />
<ci>C0Kv43_to_C1Kv43</ci>
<ci>C0Kv43_to_CI0Kv43</ci>
</apply>
<ci>C0Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C043</ci>
<apply>
<plus />
<apply>
<times />
<ci>C1Kv43_to_C0Kv43</ci>
<ci>C1Kv43</ci>
</apply>
<apply>
<times />
<ci>CI0Kv43_to_C0Kv43</ci>
<ci>CI0Kv43</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Kv43</ci>
</apply>
<apply>
<minus />
<ci>a2_C043</ci>
<ci>a1_C043</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C143</ci>
<apply>
<times />
<apply>
<plus />
<ci>C1Kv43_to_C2Kv43</ci>
<ci>C1Kv43_to_C0Kv43</ci>
<ci>C1Kv43_to_CI1Kv43</ci>
</apply>
<ci>C1Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C143</ci>
<apply>
<plus />
<apply>
<times />
<ci>C2Kv43_to_C1Kv43</ci>
<ci>C2Kv43</ci>
</apply>
<apply>
<times />
<ci>CI1Kv43_to_C1Kv43</ci>
<ci>CI1Kv43</ci>
</apply>
<apply>
<times />
<ci>C0Kv43_to_C1Kv43</ci>
<ci>C0Kv43</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Kv43</ci>
</apply>
<apply>
<minus />
<ci>a2_C143</ci>
<ci>a1_C143</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_C243</ci>
<apply>
<times />
<apply>
<plus />
<ci>C2Kv43_to_C3Kv43</ci>
<ci>C2Kv43_to_C1Kv43</ci>
<ci>C2Kv43_to_CI2Kv43</ci>
</apply>
<ci>C2Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_C243</ci>
<apply>
<plus />
<apply>
<times />
<ci>C3Kv43_to_C2Kv43</ci>
<ci>C3Kv43</ci>
</apply>
<apply>
<times />
<ci>CI2Kv43_to_C2Kv43</ci>
<ci>CI2Kv43</ci>
</apply>
<apply>
<times />
<ci>C1Kv43_to_C2Kv43</ci>
<ci>C1Kv43</ci>
</apply>
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<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
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<ci>C2Kv43</ci>
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<apply>
<minus />
<ci>a2_C243</ci>
<ci>a1_C243</ci>
</apply>
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<eq />
<ci>a1_C343</ci>
<apply>
<times />
<apply>
<plus />
<ci>C3Kv43_to_OKv43</ci>
<ci>C3Kv43_to_C2Kv43</ci>
<ci>C3Kv43_to_CI3Kv43</ci>
</apply>
<ci>C3Kv43</ci>
</apply>
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<apply>
<eq />
<ci>a2_C343</ci>
<apply>
<plus />
<apply>
<times />
<ci>OKv43_to_C3Kv43</ci>
<ci>OKv43</ci>
</apply>
<apply>
<times />
<ci>CI3Kv43_to_C3Kv43</ci>
<ci>CI3Kv43</ci>
</apply>
<apply>
<times />
<ci>C2Kv43_to_C3Kv43</ci>
<ci>C2Kv43</ci>
</apply>
</apply>
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<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Kv43</ci>
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<apply>
<minus />
<ci>a2_C343</ci>
<ci>a1_C343</ci>
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<eq />
<ci>a1_O43</ci>
<apply>
<times />
<apply>
<plus />
<ci>OKv43_to_C3Kv43</ci>
<ci>OKv43_to_OIKv43</ci>
</apply>
<ci>OKv43</ci>
</apply>
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<eq />
<ci>a2_O43</ci>
<apply>
<plus />
<apply>
<times />
<ci>C3Kv43_to_OKv43</ci>
<ci>C3Kv43</ci>
</apply>
<apply>
<times />
<ci>OIKv43_to_OKv43</ci>
<ci>OIKv43</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>OKv43</ci>
</apply>
<apply>
<minus />
<ci>a2_O43</ci>
<ci>a1_O43</ci>
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</apply>
<apply>
<eq />
<ci>a1_I043</ci>
<apply>
<times />
<apply>
<plus />
<ci>CI0Kv43_to_C0Kv43</ci>
<ci>CI0Kv43_to_CI1Kv43</ci>
</apply>
<ci>CI0Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_I043</ci>
<apply>
<plus />
<apply>
<times />
<ci>C0Kv43_to_CI0Kv43</ci>
<ci>C0Kv43</ci>
</apply>
<apply>
<times />
<ci>CI1Kv43_to_CI0Kv43</ci>
<ci>CI1Kv43</ci>
</apply>
</apply>
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<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CI0Kv43</ci>
</apply>
<apply>
<minus />
<ci>a2_I043</ci>
<ci>a1_I043</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_I143</ci>
<apply>
<times />
<apply>
<plus />
<ci>CI1Kv43_to_CI2Kv43</ci>
<ci>CI1Kv43_to_C1Kv43</ci>
<ci>CI1Kv43_to_CI0Kv43</ci>
</apply>
<ci>CI1Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_I143</ci>
<apply>
<plus />
<apply>
<times />
<ci>CI2Kv43_to_CI1Kv43</ci>
<ci>CI2Kv43</ci>
</apply>
<apply>
<times />
<ci>C1Kv43_to_CI1Kv43</ci>
<ci>C1Kv43</ci>
</apply>
<apply>
<times />
<ci>CI0Kv43_to_CI1Kv43</ci>
<ci>CI0Kv43</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Kv43</ci>
</apply>
<apply>
<minus />
<ci>a2_I143</ci>
<ci>a1_I143</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_I243</ci>
<apply>
<times />
<apply>
<plus />
<ci>CI2Kv43_to_CI3Kv43</ci>
<ci>CI2Kv43_to_C2Kv43</ci>
<ci>CI2Kv43_to_CI1Kv43</ci>
</apply>
<ci>CI2Kv43</ci>
</apply>
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<apply>
<eq />
<ci>a2_I243</ci>
<apply>
<plus />
<apply>
<times />
<ci>CI3Kv43_to_CI2Kv43</ci>
<ci>CI3Kv43</ci>
</apply>
<apply>
<times />
<ci>C2Kv43_to_CI2Kv43</ci>
<ci>C2Kv43</ci>
</apply>
<apply>
<times />
<ci>CI1Kv43_to_CI2Kv43</ci>
<ci>CI1Kv43</ci>
</apply>
</apply>
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<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Kv43</ci>
</apply>
<apply>
<minus />
<ci>a2_I243</ci>
<ci>a1_I243</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a1_I343</ci>
<apply>
<times />
<apply>
<plus />
<ci>CI3Kv43_to_OIKv43</ci>
<ci>CI3Kv43_to_C3Kv43</ci>
<ci>CI3Kv43_to_CI2Kv43</ci>
</apply>
<ci>CI3Kv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_I343</ci>
<apply>
<plus />
<apply>
<times />
<ci>OIKv43_to_CI3Kv43</ci>
<ci>OIKv43</ci>
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<apply>
<times />
<ci>C3Kv43_to_CI3Kv43</ci>
<ci>C3Kv43</ci>
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<apply>
<times />
<ci>CI2Kv43_to_CI3Kv43</ci>
<ci>CI2Kv43</ci>
</apply>
</apply>
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<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Kv43</ci>
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<apply>
<minus />
<ci>a2_I343</ci>
<ci>a1_I343</ci>
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<apply>
<eq />
<ci>a1_OI43</ci>
<apply>
<times />
<apply>
<plus />
<ci>OIKv43_to_OKv43</ci>
<ci>OIKv43_to_CI3Kv43</ci>
</apply>
<ci>OIKv43</ci>
</apply>
</apply>
<apply>
<eq />
<ci>a2_OI43</ci>
<apply>
<plus />
<apply>
<times />
<ci>OKv43_to_OIKv43</ci>
<ci>OKv43</ci>
</apply>
<apply>
<times />
<ci>CI3Kv43_to_OIKv43</ci>
<ci>CI3Kv43</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>OIKv43</ci>
</apply>
<apply>
<minus />
<ci>a2_OI43</ci>
<ci>a1_OI43</ci>
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</apply>
</math>
</component>
<component name="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES">
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.fb" name="fb" units="dimensionless" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.v1" initial_value="1.8" name="v1" units="per_ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.Krb" initial_value="3.29" name="Krb" units="mM" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.tautr" initial_value="0.5747" name="tautr" units="ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.CaNSR" name="CaNSR" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.O1_RyR" name="O1_RyR" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jrel" name="Jrel" public_interface="out" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jxfer" name="Jxfer" public_interface="out" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.vmaxr" initial_value="0.318e-3" name="vmaxr" units="per_ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.vmaxf" initial_value="0.0748e-3" name="vmaxf" units="per_ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.KSR" initial_value="1.2" name="KSR" units="mM" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.Nfb" initial_value="1.2" name="Nfb" units="dimensionless" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jup" name="Jup" public_interface="out" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.rb" name="rb" units="dimensionless" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.Cai" name="Cai" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.Kfb" initial_value="0.000168" name="Kfb" units="mM" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.O2_RyR" name="O2_RyR" public_interface="in" units="dimensionless" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jtr" name="Jtr" public_interface="out" units="mM_per_ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.CaJSR" name="CaJSR" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.CaSS" name="CaSS" public_interface="in" units="mM" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.tauxfer" initial_value="26.7" name="tauxfer" units="ms" />
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES.Nrb" initial_value="1" name="Nrb" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>fb</ci>
<apply>
<power />
<apply>
<divide />
<ci>Cai</ci>
<ci>Kfb</ci>
</apply>
<ci>Nfb</ci>
</apply>
</apply>
<apply>
<eq />
<ci>rb</ci>
<apply>
<power />
<apply>
<divide />
<ci>CaNSR</ci>
<ci>Krb</ci>
</apply>
<ci>Nrb</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Jup</ci>
<apply>
<divide />
<apply>
<times />
<ci>KSR</ci>
<apply>
<minus />
<apply>
<times />
<ci>vmaxf</ci>
<ci>fb</ci>
</apply>
<apply>
<times />
<ci>vmaxr</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<ci>fb</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Jrel</ci>
<apply>
<times />
<ci>v1</ci>
<apply>
<plus />
<ci>O1_RyR</ci>
<ci>O2_RyR</ci>
</apply>
<apply>
<minus />
<ci>CaJSR</ci>
<ci>CaSS</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Jtr</ci>
<apply>
<divide />
<apply>
<minus />
<ci>CaNSR</ci>
<ci>CaJSR</ci>
</apply>
<ci>tautr</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Jxfer</ci>
<apply>
<divide />
<apply>
<minus />
<ci>CaSS</ci>
<ci>Cai</ci>
</apply>
<ci>tauxfer</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" />
<map_variables variable_1="Ki" variable_2="Ki" />
<map_variables variable_1="Nai" variable_2="Nai" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="Faraday" variable_2="Faraday" />
<map_variables variable_1="Nao" variable_2="Nao" />
<map_variables variable_1="Ko" variable_2="Ko" />
<map_variables variable_1="RT_over_F" variable_2="RT_over_F" />
</connection>
<connection>
<map_components component_1="IKs" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" />
<map_variables variable_1="O1ks" variable_2="O1ks" />
<map_variables variable_1="O2ks" variable_2="O2ks" />
</connection>
<connection>
<map_components component_1="IKr" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" />
<map_variables variable_1="OHerg" variable_2="OHerg" />
</connection>
<connection>
<map_components component_1="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" />
<map_variables variable_1="OKv14" variable_2="OKv14" />
</connection>
<connection>
<map_components component_1="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" />
<map_variables variable_1="Jtr" variable_2="Jtr" />
<map_variables variable_1="Jup" variable_2="Jup" />
<map_variables variable_1="Jxfer" variable_2="Jxfer" />
<map_variables variable_1="Jrel" variable_2="Jrel" />
</connection>
<connection>
<map_components component_1="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES" component_2="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES" />
<map_variables variable_1="O1_RyR" variable_2="O1_RyR" />
<map_variables variable_1="O2_RyR" variable_2="O2_RyR" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="INa" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="Faraday" variable_2="Faraday" />
<map_variables variable_1="Rgas" variable_2="Rgas" />
<map_variables variable_1="RT_over_F" variable_2="RToverF" />
</connection>
<connection>
<map_components component_1="environment" component_2="IKs" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="COMPUTE_REVERSAL_POTENTIALS" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" />
<map_variables variable_1="EK" variable_2="EK" />
<map_variables variable_1="ENa" variable_2="ENa" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_ICa_ICaK" />
<map_variables variable_1="Ki" variable_2="Ki" />
<map_variables variable_1="Cao" variable_2="Cao" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="Faraday" variable_2="Faraday" />
<map_variables variable_1="Cai" variable_2="Cai" />
<map_variables variable_1="Ko" variable_2="Ko" />
<map_variables variable_1="RT_over_F" variable_2="RT_over_F" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_REVERSAL_POTENTIALS" />
<map_variables variable_1="Ki" variable_2="Ki" />
<map_variables variable_1="Nai" variable_2="Nai" />
<map_variables variable_1="Cao" variable_2="Cao" />
<map_variables variable_1="Cai" variable_2="Cai" />
<map_variables variable_1="Nao" variable_2="Nao" />
<map_variables variable_1="Ko" variable_2="Ko" />
<map_variables variable_1="RT_over_F" variable_2="RT_over_F" />
</connection>
<connection>
<map_components component_1="I_stimulus" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" />
<map_variables variable_1="i_Stim" variable_2="i_Stim" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES" />
<map_variables variable_1="CaJSR" variable_2="CaJSR" />
<map_variables variable_1="CaNSR" variable_2="CaNSR" />
<map_variables variable_1="Cai" variable_2="Cai" />
<map_variables variable_1="CaSS" variable_2="CaSS" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS" />
<map_variables variable_1="CaJSR" variable_2="CaJSR" />
<map_variables variable_1="Cai" variable_2="Cai" />
<map_variables variable_1="CaSS" variable_2="CaSS" />
</connection>
<connection>
<map_components component_1="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES" component_2="COMPUTE_ICa_ICaK" />
<map_variables variable_1="Open" variable_2="Open" />
<map_variables variable_1="yCa" variable_2="yCa" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES" />
<map_variables variable_1="CaSS" variable_2="CaSS" />
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="IKr" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="IKs" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" />
<map_variables variable_1="beta_SS" variable_2="beta_SS" />
<map_variables variable_1="beta_JSR" variable_2="beta_JSR" />
<map_variables variable_1="Jtrpn" variable_2="Jtrpn" />
<map_variables variable_1="beta_i" variable_2="beta_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" />
<map_variables variable_1="OKv43" variable_2="OKv43" />
</connection>
<connection>
<map_components component_1="COMPUTE_REVERSAL_POTENTIALS" component_2="COMPUTE_INaK_INaCa_ICab_IpCa" />
<map_variables variable_1="ECa" variable_2="ECa" />
</connection>
<connection>
<map_components component_1="COMPUTE_INaK_INaCa_ICab_IpCa" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" />
<map_variables variable_1="IpCa" variable_2="IpCa" />
<map_variables variable_1="ICab" variable_2="ICab" />
<map_variables variable_1="INaK" variable_2="INaK" />
<map_variables variable_1="INaCa" variable_2="INaCa" />
</connection>
<connection>
<map_components component_1="environment" component_2="I_stimulus" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="INa" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" />
<map_variables variable_1="na6" variable_2="na6" />
<map_variables variable_1="na7" variable_2="na7" />
</connection>
<connection>
<map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" />
<map_variables variable_1="INab" variable_2="INab" />
<map_variables variable_1="IKs" variable_2="IKs" />
<map_variables variable_1="IK1" variable_2="IK1" />
<map_variables variable_1="Ito1" variable_2="Ito1" />
<map_variables variable_1="IKv14_K" variable_2="IKv14_K" />
<map_variables variable_1="INa" variable_2="INa" />
<map_variables variable_1="IKv14_Na" variable_2="IKv14_Na" />
<map_variables variable_1="IKv43" variable_2="IKv43" />
<map_variables variable_1="IKr" variable_2="IKr" />
</connection>
<connection>
<map_components component_1="environment" component_2="IKr" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="COMPUTE_ICa_ICaK" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" />
<map_variables variable_1="ICa" variable_2="ICa" />
<map_variables variable_1="ICaK" variable_2="ICaK" />
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="CaSS" variable_2="CaSS" />
</connection>
<connection>
<map_components component_1="environment" component_2="INa" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_INaK_INaCa_ICab_IpCa" />
<map_variables variable_1="Nai" variable_2="Nai" />
<map_variables variable_1="Cao" variable_2="Cao" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="Cai" variable_2="Cai" />
<map_variables variable_1="Nao" variable_2="Nao" />
<map_variables variable_1="Ko" variable_2="Ko" />
<map_variables variable_1="RT_over_F" variable_2="RT_over_F" />
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES" />
<map_variables variable_1="time" variable_2="time" />
</connection>
</model>
