- Author:
- Axel Loewe <axel.loewe@kit.edu>
- Date:
- 2019-08-07 10:38:20+02:00
- Desc:
- Initial cellml
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/58f/rawfile/263a57f87962d0e4826ee374b456936e3618a20f/LoeweLutzFabbriSeveri.cellml
<?xml version="1.0" encoding="utf-8"?>
<model name="Loewe_Lutz_Fabbri_Severi" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<title>Loewe-Lutz-Fabbri-Severi human sinus node cellular electrophysiology model</title>
<para>
Loewe et al., <emphasis>Biophysical Journal 2019</emphasis>,
<ulink url="https://doi.org/10.1016/j.bpj.2019.07.037">doi:10.1016/j.bpj.2019.07.037</ulink>
</para>
</article>
</documentation>
<units name="mV">
<unit exponent="1" units="gram"/>
<unit exponent="2" units="metre"/>
<unit exponent="-3" units="second"/>
<unit exponent="-1" units="ampere"/>
</units>
<units name="s2_A_per_g_per_m2">
<unit exponent="-1" units="gram"/>
<unit exponent="-2" units="metre"/>
<unit exponent="2" units="second"/>
<unit exponent="1" units="ampere"/>
</units>
<units name="per_mV">
<unit exponent="-1" units="gram"/>
<unit exponent="-2" units="metre"/>
<unit exponent="3" units="second"/>
<unit exponent="1" units="ampere"/>
</units>
<units name="nA">
<unit exponent="1" multiplier="1e-09" units="ampere"/>
</units>
<units name="uS">
<unit exponent="-1" multiplier="1e-09" units="gram"/>
<unit exponent="-2" units="metre"/>
<unit exponent="3" units="second"/>
<unit exponent="2" units="ampere"/>
</units>
<units name="mM">
<unit exponent="-3" units="metre"/>
<unit exponent="1" units="mole"/>
</units>
<units name="uF">
<unit exponent="-1" multiplier="1e-09" units="gram"/>
<unit exponent="-2" units="metre"/>
<unit exponent="4" units="second"/>
<unit exponent="2" units="ampere"/>
</units>
<units name="C_per_mol">
<unit exponent="1" units="second"/>
<unit exponent="1" units="ampere"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="mJ_per_mol_per_K">
<unit exponent="1" units="gram"/>
<unit exponent="2" units="metre"/>
<unit exponent="-2" units="second"/>
<unit exponent="-1" units="kelvin"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="uL">
<unit exponent="3" multiplier="1e-09" units="metre"/>
</units>
<units name="1_times_1000000000">
<unit exponent="1" multiplier="1000000000.0" units="dimensionless"/>
</units>
<units name="um">
<unit exponent="1" multiplier="1e-06" units="metre"/>
</units>
<units name="1_times_1000000">
<unit exponent="1" multiplier="1000000.0" units="dimensionless"/>
</units>
<units name="uM">
<unit exponent="-3" multiplier="0.001" units="metre"/>
<unit exponent="1" units="mole"/>
</units>
<units name="m3_per_s_per_mol">
<unit exponent="3" units="metre"/>
<unit exponent="-1" units="second"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="m3_A_per_mol_times_1e_minus_09">
<unit exponent="3" multiplier="1e-09" units="metre"/>
<unit exponent="1" units="ampere"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="m3_per_mol">
<unit exponent="3" units="metre"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="mol_per_m3_per_s">
<unit exponent="-3" units="metre"/>
<unit exponent="-1" units="second"/>
<unit exponent="1" units="mole"/>
</units>
<units name="m6_per_s_per_mol2">
<unit exponent="6" units="metre"/>
<unit exponent="-1" units="second"/>
<unit exponent="-2" units="mole"/>
</units>
<component name="Voltage_clamp">
<variable initial_value="0.5" name="t_test" units="second"/>
<variable initial_value="0.5" name="t_holding" units="second"/>
<variable initial_value="-35.0" name="V_test" units="mV"/>
<variable name="V_clamp" public_interface="out" units="mV"/>
<variable initial_value="-45.0" name="V_holding" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_clamp</ci>
<piecewise>
<piece>
<ci>V_test</ci>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<ci>t_holding</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>t_holding</ci>
<ci>t_test</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>V_holding</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="i_Na_m_gate">
<variable name="tau_m" units="second"/>
<variable name="alpha_m" units="becquerel"/>
<variable initial_value="0.3777047" name="m" public_interface="out" units="dimensionless"/>
<variable name="m_infinity" units="dimensionless"/>
<variable name="E0_m" units="mV"/>
<variable initial_value="1e-05" name="delta_m" units="mV"/>
<variable name="beta_m" units="becquerel"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_m</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<piecewise>
<piece>
<cn cellml:units="becquerel">2000.0</cn>
<apply>
<lt/>
<apply>
<abs/>
<ci>E0_m</ci>
</apply>
<ci>delta_m</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="s2_A_per_g_per_m2">200.0</cn>
<ci>E0_m</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<ci>E0_m</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>m_infinity</ci>
<ci>m</ci>
</apply>
<ci>tau_m</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>m_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">42.0504</cn>
</apply>
</apply>
<cn cellml:units="mV">8.3106</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E0_m</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">41.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="becquerel">8000.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.056</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">66.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_f">
<variable name="i_f_i_f" public_interface="out" units="nA"/>
<variable initial_value="0.0117" name="g_f_K" units="uS"/>
<variable name="i_fNa" public_interface="out" units="nA"/>
<variable initial_value="0.00696" name="g_f_Na" units="uS"/>
<variable name="i_fK" public_interface="out" units="nA"/>
<variable name="y" public_interface="in" units="dimensionless"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="E_Na" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_f_i_f</ci>
<apply>
<plus/>
<ci>i_fNa</ci>
<ci>i_fK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fNa</ci>
<apply>
<times/>
<apply>
<times/>
<ci>y</ci>
<ci>g_f_Na</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fK</ci>
<apply>
<times/>
<apply>
<times/>
<ci>y</ci>
<ci>g_f_K</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Kur_rKur_gate">
<variable initial_value="9.059024e-03" name="r_Kur" public_interface="out" units="dimensionless"/>
<variable name="r_Kur_infinity" units="dimensionless"/>
<variable name="tau_r_Kur" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r_Kur</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_Kur_infinity</ci>
<ci>r_Kur</ci>
</apply>
<ci>tau_r_Kur</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>r_Kur_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">6.0</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">8.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r_Kur</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">0.009</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">5.0</cn>
</apply>
<cn cellml:units="mV">12.0</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0005</cn>
</apply>
</apply>
</math>
</component>
<component name="i_Kr_pa_gate">
<variable name="pa_infinity" units="dimensionless"/>
<variable initial_value="0.3450797" name="paS" public_interface="out" units="dimensionless"/>
<variable name="tau_paS" units="second"/>
<variable initial_value="8.34449800000000054e-03" name="paF" public_interface="out" units="dimensionless"/>
<variable name="tau_paF" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>pa_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">10.0144</cn>
</apply>
</apply>
<cn cellml:units="mV">7.6607</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>paS</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pa_infinity</ci>
<ci>paS</ci>
</apply>
<ci>tau_paS</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_paS</ci>
<apply>
<divide/>
<cn cellml:units="second">0.84655354</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="mV">17.0</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.15</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">21.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>paF</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pa_infinity</ci>
<ci>paF</ci>
</apply>
<ci>tau_paF</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_paF</ci>
<apply>
<divide/>
<cn cellml:units="second">1.0</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">30.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">12.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Ks_n_gate">
<variable name="tau_n" units="second"/>
<variable name="alpha_n" units="becquerel"/>
<variable initial_value="0.1057902" name="n" public_interface="out" units="dimensionless"/>
<variable name="i_Ks_n_gate_Iso_shift" units="mV"/>
<variable name="n_infinity" units="dimensionless"/>
<variable name="beta_n" units="becquerel"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_n</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>alpha_n</ci>
<ci>beta_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_n</ci>
<apply>
<divide/>
<cn cellml:units="becquerel">28.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">40.0</cn>
</apply>
<ci>i_Ks_n_gate_Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="mV">3.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>n</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>n_infinity</ci>
<ci>n</ci>
</apply>
<ci>tau_n</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks_n_gate_Iso_shift</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="mV">14.0</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="mV">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>n_infinity</ci>
<apply>
<root/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">0.6383</cn>
</apply>
<ci>i_Ks_n_gate_Iso_shift</ci>
</apply>
</apply>
<cn cellml:units="mV">10.7071</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_n</ci>
<apply>
<times/>
<cn cellml:units="becquerel">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>i_Ks_n_gate_Iso_shift</ci>
</apply>
<cn cellml:units="mV">5.0</cn>
</apply>
</apply>
<cn cellml:units="mV">25.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Kr">
<variable name="g_Kr" units="uS"/>
<variable name="i_Kr_i_Kr" public_interface="out" units="nA"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="paS" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="piy" public_interface="in" units="dimensionless"/>
<variable name="paF" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Kr</ci>
<apply>
<times/>
<cn cellml:units="uS">0.004989099</cn>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Kr_i_Kr</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>g_Kr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.9</cn>
<ci>paF</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1</cn>
<ci>paS</ci>
</apply>
</apply>
</apply>
<ci>piy</ci>
</apply>
</apply>
</math>
</component>
<component name="Membrane">
<variable initial_value="5.7e-05" name="C" units="uF"/>
<variable initial_value="-46.1899" name="V_ode" units="mV"/>
<variable initial_value="9.64853414999999950e+04" name="F" public_interface="out" units="C_per_mol"/>
<variable initial_value="0.0" name="clamp_mode" units="dimensionless"/>
<variable initial_value="8314.472" name="Membrane_R" units="mJ_per_mol_per_K"/>
<variable initial_value="310.0" name="T" units="kelvin"/>
<variable name="V" public_interface="out" units="mV"/>
<variable name="i_tot" units="nA"/>
<variable name="RTONF" public_interface="out" units="mV"/>
<variable name="i_Kur_i_Kur" public_interface="in" units="nA"/>
<variable name="i_Kr_i_Kr" public_interface="in" units="nA"/>
<variable name="i_f_i_f" public_interface="in" units="nA"/>
<variable name="i_CaL_i_CaL" public_interface="in" units="nA"/>
<variable name="i_CaT_i_CaT" public_interface="in" units="nA"/>
<variable name="i_Ks_i_Ks" public_interface="in" units="nA"/>
<variable name="i_NaK_i_NaK" public_interface="in" units="nA"/>
<variable name="i_NaCa_i_NaCa" public_interface="in" units="nA"/>
<variable name="i_KACh_i_KACh" public_interface="in" units="nA"/>
<variable name="i_Na_i_Na" public_interface="in" units="nA"/>
<variable name="i_SK_i_SK" public_interface="in" units="nA"/>
<variable name="i_to_i_to" public_interface="in" units="nA"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="V_clamp" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V_ode</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>i_tot</ci>
</apply>
<ci>C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V</ci>
<piecewise>
<piece>
<ci>V_clamp</ci>
<apply>
<geq/>
<ci>clamp_mode</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</piece>
<otherwise>
<ci>V_ode</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_tot</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>i_f_i_f</ci>
<ci>i_Kr_i_Kr</ci>
</apply>
<ci>i_Ks_i_Ks</ci>
</apply>
<ci>i_to_i_to</ci>
</apply>
<ci>i_NaK_i_NaK</ci>
</apply>
<ci>i_NaCa_i_NaCa</ci>
</apply>
<ci>i_Na_i_Na</ci>
</apply>
<ci>i_CaL_i_CaL</ci>
</apply>
<ci>i_CaT_i_CaT</ci>
</apply>
<ci>i_KACh_i_KACh</ci>
</apply>
<ci>i_Kur_i_Kur</ci>
</apply>
<ci>i_SK_i_SK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>RTONF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Membrane_R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="i_NaK">
<variable initial_value="0.137171" name="i_NaK_max" units="nA"/>
<variable initial_value="14.0" name="Km_Nap" units="mM"/>
<variable initial_value="1.4" name="Km_Kp" units="mM"/>
<variable name="i_NaK_i_NaK" public_interface="out" units="nA"/>
<variable name="i_NaK_Iso_increase" units="dimensionless"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<variable name="E_Na" public_interface="in" units="mV"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK_i_NaK</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>i_NaK_Iso_increase</ci>
<ci>i_NaK_max</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Kp</ci>
<ci>Ko</ci>
</apply>
<cn cellml:units="dimensionless">1.2</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nap</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.3</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
<cn cellml:units="mV">110.0</cn>
</apply>
</apply>
<cn cellml:units="mV">20.0</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK_Iso_increase</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1.2</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1.0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="Cell_parameters">
<variable initial_value="0.0116" name="V_nsr_part" units="dimensionless"/>
<variable name="V_sub" public_interface="out" units="uL"/>
<variable initial_value="3.9" name="R_cell" units="um"/>
<variable initial_value="0.0012" name="V_jsr_part" units="dimensionless"/>
<variable initial_value="0.46" name="V_i_part" units="dimensionless"/>
<variable initial_value="67.0" name="L_cell" units="um"/>
<variable name="V_nsr" public_interface="out" units="uL"/>
<variable name="V_jsr" public_interface="out" units="uL"/>
<variable name="V_i" public_interface="out" units="uL"/>
<variable initial_value="0.02" name="L_sub" units="um"/>
<variable name="V_cell" units="uL"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_sub</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="1_times_1000000000">1e-09</cn>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<cn cellml:units="dimensionless">3.14159265359</cn>
</apply>
<ci>L_sub</ci>
</apply>
<apply>
<minus/>
<ci>R_cell</ci>
<apply>
<divide/>
<ci>L_sub</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<ci>L_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_nsr</ci>
<apply>
<times/>
<ci>V_nsr_part</ci>
<ci>V_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_jsr</ci>
<apply>
<times/>
<ci>V_jsr_part</ci>
<ci>V_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_i</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>V_i_part</ci>
<ci>V_cell</ci>
</apply>
<ci>V_sub</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_cell</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="1_times_1000000000">1e-09</cn>
<cn cellml:units="dimensionless">3.14159265359</cn>
</apply>
<apply>
<power/>
<ci>R_cell</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<ci>L_cell</ci>
</apply>
</apply>
</math>
</component>
<component name="Nai_concentration">
<variable initial_value="6.084085" name="Nai" public_interface="out" units="mM"/>
<variable name="i_fNa" public_interface="in" units="nA"/>
<variable name="i_siNa" public_interface="in" units="nA"/>
<variable name="V_i" public_interface="in" units="uL"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="V_sub" public_interface="in" units="uL"/>
<variable name="i_NaK_i_NaK" public_interface="in" units="nA"/>
<variable name="i_NaCa_i_NaCa" public_interface="in" units="nA"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="i_Na_i_Na" public_interface="in" units="nA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="1_times_1000000">1.0</cn>
</apply>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>i_Na_i_Na</ci>
<ci>i_fNa</ci>
</apply>
<ci>i_siNa</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>i_NaK_i_NaK</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>i_NaCa_i_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="1_times_1000000">1.0</cn>
<apply>
<plus/>
<ci>V_i</ci>
<ci>V_sub</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_NaCa">
<variable name="k21" units="dimensionless"/>
<variable initial_value="26.44" name="Kcni" units="mM"/>
<variable initial_value="0.1369" name="Qci" units="dimensionless"/>
<variable initial_value="0.0" name="Qco" units="dimensionless"/>
<variable name="k12" units="dimensionless"/>
<variable name="k34" units="dimensionless"/>
<variable name="i_NaCa_i_NaCa" public_interface="out" units="nA"/>
<variable name="k14" units="dimensionless"/>
<variable initial_value="3.663" name="Kco" units="mM"/>
<variable initial_value="0.0207" name="Kci" units="mM"/>
<variable initial_value="3.343" name="K_NaCa" units="nA"/>
<variable name="do" units="dimensionless"/>
<variable name="di" units="dimensionless"/>
<variable name="x2" units="dimensionless"/>
<variable name="x3" units="dimensionless"/>
<variable name="x1" units="dimensionless"/>
<variable name="x4" units="dimensionless"/>
<variable initial_value="0.4315" name="Qn" units="dimensionless"/>
<variable initial_value="4.663" name="K3no" units="mM"/>
<variable initial_value="26.44" name="K3ni" units="mM"/>
<variable initial_value="2.289" name="K2ni" units="mM"/>
<variable name="k23" units="dimensionless"/>
<variable name="k32" units="dimensionless"/>
<variable name="k41" units="dimensionless"/>
<variable initial_value="561.4" name="K2no" units="mM"/>
<variable name="k43" units="dimensionless"/>
<variable initial_value="1628.0" name="K1no" units="mM"/>
<variable initial_value="395.3" name="K1ni" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="RTONF" public_interface="in" units="mV"/>
<variable name="Ca_sub" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k21</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Kco</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qco</ci>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<ci>do</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k12</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_sub</ci>
<ci>Kci</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qci</ci>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<ci>di</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k34</ci>
<apply>
<divide/>
<ci>Nao</ci>
<apply>
<plus/>
<ci>K3no</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa_i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>x2</ci>
<ci>k21</ci>
</apply>
<apply>
<times/>
<ci>x1</ci>
<ci>k12</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>x1</ci>
<ci>x2</ci>
</apply>
<ci>x3</ci>
</apply>
<ci>x4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k14</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K1ni</ci>
</apply>
<ci>Nai</ci>
</apply>
<ci>K2ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K3ni</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qn</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>di</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>do</ci>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Kco</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qco</ci>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K1no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K2no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K3no</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>di</ci>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Ca_sub</ci>
<ci>Kci</ci>
</apply>
<apply>
<plus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qci</ci>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>Nai</ci>
<ci>Kcni</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K1ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K2ni</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K3ni</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x2</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<ci>k32</ci>
<ci>k43</ci>
</apply>
<apply>
<plus/>
<ci>k14</ci>
<ci>k12</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>k41</ci>
<ci>k12</ci>
</apply>
<apply>
<plus/>
<ci>k34</ci>
<ci>k32</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x3</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<ci>k14</ci>
<ci>k43</ci>
</apply>
<apply>
<plus/>
<ci>k23</ci>
<ci>k21</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>k12</ci>
<ci>k23</ci>
</apply>
<apply>
<plus/>
<ci>k43</ci>
<ci>k41</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x1</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<ci>k41</ci>
<ci>k34</ci>
</apply>
<apply>
<plus/>
<ci>k23</ci>
<ci>k21</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>k21</ci>
<ci>k32</ci>
</apply>
<apply>
<plus/>
<ci>k43</ci>
<ci>k41</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x4</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<ci>k23</ci>
<ci>k34</ci>
</apply>
<apply>
<plus/>
<ci>k14</ci>
<ci>k12</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>k14</ci>
<ci>k21</ci>
</apply>
<apply>
<plus/>
<ci>k34</ci>
<ci>k32</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k23</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K1no</ci>
</apply>
<ci>Nao</ci>
</apply>
<ci>K2no</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<ci>Nao</ci>
<ci>K3no</ci>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qn</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<ci>do</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k32</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>Qn</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k41</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Qn</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k43</ci>
<apply>
<divide/>
<ci>Nai</ci>
<apply>
<plus/>
<ci>K3ni</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_CaT_dT_gate">
<variable name="dT_infinity" units="dimensionless"/>
<variable initial_value="0.192108" name="dT" public_interface="out" units="dimensionless"/>
<variable name="tau_dT" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dT_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">38.3</cn>
</apply>
</apply>
<cn cellml:units="mV">5.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>dT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>dT_infinity</ci>
<ci>dT</ci>
</apply>
<ci>tau_dT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_dT</ci>
<apply>
<divide/>
<cn cellml:units="second">0.001</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.068</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">38.3</cn>
</apply>
<cn cellml:units="mV">30.0</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1.068</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">38.3</cn>
</apply>
</apply>
<cn cellml:units="mV">30.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>time</ci>
<cn cellml:units="second">0.0</cn>
</apply>
</math>
</component>
<component name="i_SK_x_gate">
<variable initial_value="6.77693899999999988e-02" name="x" public_interface="out" units="dimensionless"/>
<variable name="x_infinity" units="dimensionless"/>
<variable initial_value="2.2" name="n_SK" units="dimensionless"/>
<variable name="tau_x" units="second"/>
<variable initial_value="0.7" name="EC50_SK" units="uM"/>
<variable name="Ca_sub" public_interface="in" units="mM"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_infinity</ci>
<ci>x</ci>
</apply>
<ci>tau_x</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_infinity</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.81</cn>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1000.0</cn>
<ci>Ca_sub</ci>
</apply>
<cn cellml:units="mM">1.0</cn>
</apply>
<ci>n_SK</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1000.0</cn>
<ci>Ca_sub</ci>
</apply>
<cn cellml:units="mM">1.0</cn>
</apply>
<ci>n_SK</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>EC50_SK</ci>
<cn cellml:units="uM">1.0</cn>
</apply>
<ci>n_SK</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_x</ci>
<apply>
<divide/>
<cn cellml:units="second">0.001</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.047</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1000.0</cn>
<ci>Ca_sub</ci>
</apply>
<cn cellml:units="mM">1.0</cn>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<cn cellml:units="dimensionless">76.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_SK">
<variable initial_value="0.000165" name="g_SK" units="uS"/>
<variable name="i_SK_i_SK" public_interface="out" units="nA"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="x" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SK_i_SK</ci>
<apply>
<times/>
<apply>
<times/>
<ci>g_SK</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<ci>x</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Kur">
<variable initial_value="7.062e-05" name="g_Kur" units="uS"/>
<variable name="i_Kur_i_Kur" public_interface="out" units="nA"/>
<variable name="s_Kur" public_interface="in" units="dimensionless"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="r_Kur" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kur_i_Kur</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>g_Kur</ci>
<ci>r_Kur</ci>
</apply>
<ci>s_Kur</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_to_r_gate">
<variable name="r_infinity" units="dimensionless"/>
<variable initial_value="1.24570600000000007e-02" name="r" public_interface="out" units="dimensionless"/>
<variable name="tau_r" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">19.3</cn>
</apply>
</apply>
<cn cellml:units="mV">15.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<cn cellml:units="dimensionless">0.66</cn>
</apply>
<cn cellml:units="dimensionless">1.4</cn>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">15.59</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.037</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.09</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">30.61</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.369</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.12</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">23.84</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">2.98</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Kur_sKur_gate">
<variable initial_value="0.8655135" name="s_Kur" public_interface="out" units="dimensionless"/>
<variable name="tau_s_Kur" units="second"/>
<variable name="s_Kur_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_Kur</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_Kur_infinity</ci>
<ci>s_Kur</ci>
</apply>
<ci>tau_s_Kur</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_Kur</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">0.59</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">60.0</cn>
</apply>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">3.05</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>s_Kur_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">7.5</cn>
</apply>
<cn cellml:units="mV">10.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Ks">
<variable name="g_Ks" units="uS"/>
<variable name="i_Ks_i_Ks" public_interface="out" units="nA"/>
<variable initial_value="8.63714000000000018e-04" name="g_Ks_" units="uS"/>
<variable name="E_Ks" units="mV"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<variable name="n" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="RTONF" public_interface="in" units="mV"/>
<variable name="Ki" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Ks</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="dimensionless">1.2</cn>
<ci>g_Ks_</ci>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0.0</cn>
</apply>
</piece>
<otherwise>
<ci>g_Ks_</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_Ks_i_Ks</ci>
<apply>
<times/>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
</apply>
<apply>
<power/>
<ci>n</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ks</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_buffering">
<variable name="delta_fTC" public_interface="out" units="becquerel"/>
<variable initial_value="751.0" name="kb_TMM" units="becquerel"/>
<variable initial_value="7.51" name="kb_TMC" units="becquerel"/>
<variable initial_value="2277.0" name="kf_TMM" units="m3_per_s_per_mol"/>
<variable initial_value="227700.0" name="kf_TMC" units="m3_per_s_per_mol"/>
<variable initial_value="1.75433543399999991e+02" name="kf_CQ" units="m3_per_s_per_mol"/>
<variable initial_value="446.0" name="kb_TC" units="becquerel"/>
<variable initial_value="2.5" name="Mgi" units="mM"/>
<variable initial_value="542.0" name="kb_CM" units="becquerel"/>
<variable initial_value="445.0" name="kb_CQ" units="becquerel"/>
<variable initial_value="88800.0" name="kf_TC" units="m3_per_s_per_mol"/>
<variable initial_value="0.031" name="TC_tot" public_interface="out" units="mM"/>
<variable initial_value="0.062" name="TMC_tot" public_interface="out" units="mM"/>
<variable initial_value="0.1878388" name="fCQ" units="dimensionless"/>
<variable name="delta_fTMC" public_interface="out" units="becquerel"/>
<variable initial_value="10.0" name="CQ_tot" public_interface="out" units="mM"/>
<variable name="delta_fTMM" units="becquerel"/>
<variable name="delta_fCQ" public_interface="out" units="becquerel"/>
<variable initial_value="0.045" name="CM_tot" public_interface="out" units="mM"/>
<variable initial_value="0.206602" name="fCMs" units="dimensionless"/>
<variable name="delta_fCMi" public_interface="out" units="becquerel"/>
<variable initial_value="0.0246504" name="fTC" units="dimensionless"/>
<variable initial_value="0.5920168" name="fTMM" units="dimensionless"/>
<variable initial_value="0.2776014" name="fCMi" units="dimensionless"/>
<variable initial_value="0.329845" name="fTMC" units="dimensionless"/>
<variable initial_value="1.64198609899999993e+06" name="kf_CM" units="m3_per_s_per_mol"/>
<variable name="delta_fCMs" public_interface="out" units="becquerel"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca_sub" public_interface="in" units="mM"/>
<variable name="Ca_jsr" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>delta_fTC</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kf_TC</ci>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>fTC</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TC</ci>
<ci>fTC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCQ</ci>
</apply>
<ci>delta_fCQ</ci>
</apply>
<apply>
<eq/>
<ci>delta_fTMC</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kf_TMC</ci>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>fTMC</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TMC</ci>
<ci>fTMC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_fTMM</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kf_TMM</ci>
<ci>Mgi</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>fTMC</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kb_TMM</ci>
<ci>fTMM</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>delta_fCQ</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kf_CQ</ci>
<ci>Ca_jsr</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>fCQ</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CQ</ci>
<ci>fCQ</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCMs</ci>
</apply>
<ci>delta_fCMs</ci>
</apply>
<apply>
<eq/>
<ci>delta_fCMi</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kf_CM</ci>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>fCMi</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CM</ci>
<ci>fCMi</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTC</ci>
</apply>
<ci>delta_fTC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTMM</ci>
</apply>
<ci>delta_fTMM</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCMi</ci>
</apply>
<ci>delta_fCMi</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fTMC</ci>
</apply>
<ci>delta_fTMC</ci>
</apply>
<apply>
<eq/>
<ci>delta_fCMs</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kf_CM</ci>
<ci>Ca_sub</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>fCMs</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kb_CM</ci>
<ci>fCMs</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_to_q_gate">
<variable initial_value="0.4735559" name="q" public_interface="out" units="dimensionless"/>
<variable name="q_infinity" units="dimensionless"/>
<variable name="tau_q" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>q</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>q_infinity</ci>
<ci>q</ci>
</apply>
<ci>tau_q</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">49.0</cn>
</apply>
<cn cellml:units="mV">13.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_q</ci>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<cn cellml:units="dimensionless">0.6</cn>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">65.17</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="becquerel">0.57</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.08</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">44.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="becquerel">0.065</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.1</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">45.93</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">10.1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_to">
<variable name="i_to_i_to" public_interface="out" units="nA"/>
<variable initial_value="1.67347999999999998e-03" name="g_to" units="uS"/>
<variable name="q" public_interface="in" units="dimensionless"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="r" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_to_i_to</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>g_to</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<ci>q</ci>
</apply>
<ci>r</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL">
<variable initial_value="0.5046812" name="P_CaL" units="m3_A_per_mol_times_1e_minus_09"/>
<variable name="i_CaL_i_CaL" public_interface="out" units="nA"/>
<variable name="i_siNa" public_interface="out" units="nA"/>
<variable name="i_siK" public_interface="out" units="nA"/>
<variable name="i_siCa" public_interface="out" units="nA"/>
<variable name="i_CaL_Iso_increase" units="dimensionless"/>
<variable name="ACh_block" units="dimensionless"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<variable name="ACh" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="fCa" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="RTONF" public_interface="in" units="mV"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="dL" public_interface="in" units="dimensionless"/>
<variable name="fL" public_interface="in" units="dimensionless"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="Ca_sub" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaL_i_CaL</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<plus/>
<ci>i_siCa</ci>
<ci>i_siK</ci>
</apply>
<ci>i_siNa</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>ACh_block</ci>
</apply>
</apply>
<ci>i_CaL_Iso_increase</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_siNa</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.85e-05</cn>
<ci>P_CaL</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Nai</ci>
<apply>
<times/>
<ci>Nao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
</apply>
<ci>fL</ci>
</apply>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_siK</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000365</cn>
<ci>P_CaL</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>Ko</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
</apply>
<ci>fL</ci>
</apply>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_siCa</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>P_CaL</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_sub</ci>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>dL</ci>
</apply>
<ci>fL</ci>
</apply>
<ci>fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Iso_increase</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1.23</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1.0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>ACh_block</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.31</cn>
<ci>ACh</ci>
</apply>
<apply>
<plus/>
<ci>ACh</ci>
<cn cellml:units="mM">9e-05</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_CaT_fT_gate">
<variable initial_value="0.0" name="offset_fT" units="second"/>
<variable initial_value="3.74674099999999996e-02" name="fT" public_interface="out" units="dimensionless"/>
<variable name="tau_fT" units="second"/>
<variable name="fT_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fT_infinity</ci>
<ci>fT</ci>
</apply>
<ci>tau_fT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fT</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">1.0</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">16.67</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">75.0</cn>
</apply>
</apply>
<cn cellml:units="mV">83.3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">16.67</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">75.0</cn>
</apply>
<cn cellml:units="mV">15.38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>offset_fT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fT_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">58.7</cn>
</apply>
<cn cellml:units="mV">3.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Kr_pi_gate">
<variable initial_value="0.7369347" name="piy" public_interface="out" units="dimensionless"/>
<variable name="pi_infinity" units="dimensionless"/>
<variable name="tau_pi" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>piy</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>pi_infinity</ci>
<ci>piy</ci>
</apply>
<ci>tau_pi</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>pi_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">28.6</cn>
</apply>
<cn cellml:units="mV">17.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_pi</ci>
<apply>
<divide/>
<cn cellml:units="second">1.0</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">100.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="mV">54.645</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">656.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="mV">106.157</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_CaT">
<variable initial_value="0.04132" name="P_CaT" units="m3_A_per_mol_times_1e_minus_09"/>
<variable name="i_CaT_i_CaT" public_interface="out" units="nA"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="dT" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="RTONF" public_interface="in" units="mV"/>
<variable name="Ca_sub" public_interface="in" units="mM"/>
<variable name="fT" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaT_i_CaT</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>P_CaT</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>V</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_sub</ci>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>dT</ci>
</apply>
<ci>fT</ci>
</apply>
</apply>
</math>
</component>
<component name="Ionic_values">
<variable name="E_K" public_interface="out" units="mV"/>
<variable initial_value="5.4" name="Ko" public_interface="out" units="mM"/>
<variable initial_value="1.8" name="Cao" public_interface="out" units="mM"/>
<variable initial_value="140.0" name="Nao" public_interface="out" units="mM"/>
<variable name="E_Na" public_interface="out" units="mV"/>
<variable name="RTONF" public_interface="in" units="mV"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_KACh_a_gate">
<variable initial_value="2.81845900000000016e-03" name="a" public_interface="out" units="dimensionless"/>
<variable name="beta_a" units="becquerel"/>
<variable name="a_infinity" units="dimensionless"/>
<variable name="tau_a" units="second"/>
<variable name="alpha_a" units="becquerel"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="ACh" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>a</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>a_infinity</ci>
<ci>a</ci>
</apply>
<ci>tau_a</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_a</ci>
<apply>
<times/>
<cn cellml:units="becquerel">10.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.0133</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">40.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a_infinity</ci>
<apply>
<divide/>
<ci>alpha_a</ci>
<apply>
<plus/>
<ci>alpha_a</ci>
<ci>beta_a</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_a</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>alpha_a</ci>
<ci>beta_a</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_a</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="becquerel">3.5988</cn>
<cn cellml:units="becquerel">0.025641</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.2155e-06</cn>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">1.0</cn>
<ci>ACh</ci>
</apply>
<cn cellml:units="dimensionless">1.6951</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="becquerel">0.025641</cn>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_fL_gate">
<variable initial_value="0.0" name="shift_fL" units="mV"/>
<variable initial_value="0.9951828" name="fL" public_interface="out" units="dimensionless"/>
<variable name="tau_fL" units="second"/>
<variable initial_value="-12.1847" name="V_fL" units="mV"/>
<variable initial_value="5.1737" name="k_fL" units="mV"/>
<variable name="fL_infinity" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fL</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fL_infinity</ci>
<ci>fL</ci>
</apply>
<ci>tau_fL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<cn cellml:units="second">44.3</cn>
<apply>
<times/>
<cn cellml:units="second">230.0</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">36.0</cn>
</apply>
<cn cellml:units="mV">10.0</cn>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fL_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>V_fL</ci>
</apply>
<ci>shift_fL</ci>
</apply>
<ci>k_fL</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ki_concentration">
<variable initial_value="139.1382" name="Ki" public_interface="out" units="mM"/>
<variable name="i_Kur_i_Kur" public_interface="in" units="nA"/>
<variable name="V_i" public_interface="in" units="uL"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="i_Kr_i_Kr" public_interface="in" units="nA"/>
<variable name="i_fK" public_interface="in" units="nA"/>
<variable name="i_siK" public_interface="in" units="nA"/>
<variable name="V_sub" public_interface="in" units="uL"/>
<variable name="i_NaK_i_NaK" public_interface="in" units="nA"/>
<variable name="i_Ks_i_Ks" public_interface="in" units="nA"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="i_SK_i_SK" public_interface="in" units="nA"/>
<variable name="i_to_i_to" public_interface="in" units="nA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="1_times_1000000">1.0</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>i_Kur_i_Kur</ci>
<ci>i_to_i_to</ci>
</apply>
<ci>i_Kr_i_Kr</ci>
</apply>
<ci>i_Ks_i_Ks</ci>
</apply>
<ci>i_fK</ci>
</apply>
<ci>i_siK</ci>
</apply>
<ci>i_SK_i_SK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>i_NaK_i_NaK</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="1_times_1000000">1.0</cn>
<apply>
<plus/>
<ci>V_i</ci>
<ci>V_sub</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_f_y_gate">
<variable name="ACh_shift" units="mV"/>
<variable name="y_infinity" units="dimensionless"/>
<variable initial_value="0.0" name="y_shift" units="mV"/>
<variable name="i_f_y_gate_Iso_shift" units="mV"/>
<variable name="tau_y" units="second"/>
<variable initial_value="0.0103301" name="y" public_interface="out" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="ACh" public_interface="in" units="mM"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ACh_shift</ci>
<piecewise>
<piece>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="mV">1.0</cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="mV">9.898</cn>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">1.0</cn>
<ci>ACh</ci>
</apply>
<cn cellml:units="dimensionless">0.618</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="m3_per_mol">1.0</cn>
<ci>ACh</ci>
</apply>
<cn cellml:units="dimensionless">0.618</cn>
</apply>
<cn cellml:units="dimensionless">0.00122423</cn>
</apply>
</apply>
</apply>
<apply>
<gt/>
<ci>ACh</ci>
<cn cellml:units="mM">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="mV">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>y_infinity</ci>
<piecewise>
<piece>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.01329</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.99921</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">97.134</cn>
</apply>
<ci>ACh_shift</ci>
</apply>
<ci>i_f_y_gate_Iso_shift</ci>
</apply>
<ci>y_shift</ci>
</apply>
<cn cellml:units="mV">8.1752</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="mV">80.0</cn>
<ci>ACh_shift</ci>
</apply>
<ci>i_f_y_gate_Iso_shift</ci>
</apply>
<ci>y_shift</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0002501</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>ACh_shift</ci>
</apply>
<ci>i_f_y_gate_Iso_shift</ci>
</apply>
<ci>y_shift</ci>
</apply>
</apply>
<cn cellml:units="mV">12.861</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_f_y_gate_Iso_shift</ci>
<piecewise>
<piece>
<cn cellml:units="mV">7.5</cn>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="mV">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<minus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="s2_A_per_g_per_m2">0.36</cn>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">148.8</cn>
</apply>
<ci>ACh_shift</ci>
</apply>
<ci>i_f_y_gate_Iso_shift</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.066</cn>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">148.8</cn>
</apply>
<ci>ACh_shift</ci>
</apply>
<ci>i_f_y_gate_Iso_shift</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="s2_A_per_g_per_m2">0.1</cn>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">87.3</cn>
</apply>
<ci>ACh_shift</ci>
</apply>
<ci>i_f_y_gate_Iso_shift</ci>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.2</cn>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">87.3</cn>
</apply>
<ci>ACh_shift</ci>
</apply>
<ci>i_f_y_gate_Iso_shift</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.054</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
</math>
</component>
<component name="i_Na">
<variable name="i_Na_i_Na" public_interface="out" units="nA"/>
<variable initial_value="0.0" name="g_Na_L" units="uS"/>
<variable name="i_Na_" units="nA"/>
<variable name="i_Na_L" units="nA"/>
<variable initial_value="0.0223" name="g_Na" units="uS"/>
<variable name="E_mh" units="mV"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="RTONF" public_interface="in" units="mV"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="m" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="h" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Na_i_Na</ci>
<apply>
<plus/>
<ci>i_Na_</ci>
<ci>i_Na_L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<ci>h</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_mh</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_L</ci>
<apply>
<times/>
<apply>
<times/>
<ci>g_Na_L</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_mh</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_mh</ci>
<apply>
<times/>
<ci>RTONF</ci>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Nao</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Nai</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_fCa_gate">
<variable initial_value="0.7820265" name="fCa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0075" name="alpha_fCa" units="becquerel"/>
<variable name="tau_fCa" units="second"/>
<variable initial_value="0.000338" name="Km_fCa" units="mM"/>
<variable name="fCa_infinity" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca_sub" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>fCa_infinity</ci>
<ci>fCa</ci>
</apply>
<ci>tau_fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_fCa</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<ci>fCa_infinity</ci>
</apply>
<ci>alpha_fCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fCa_infinity</ci>
<apply>
<divide/>
<ci>Km_fCa</ci>
<apply>
<plus/>
<ci>Km_fCa</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_SR_release">
<variable initial_value="1.48041085000000000e+08" name="ks" units="becquerel"/>
<variable initial_value="15.0" name="MaxSR" units="dimensionless"/>
<variable name="j_SRCarel" public_interface="out" units="mol_per_m3_per_s"/>
<variable initial_value="660.0" name="kom" units="becquerel"/>
<variable name="kCaSR" units="dimensionless"/>
<variable initial_value="0.45" name="EC50_SR" units="mM"/>
<variable initial_value="1.88065699999999987e-09" name="I" units="dimensionless"/>
<variable name="kiSRCa" units="m3_per_s_per_mol"/>
<variable initial_value="1.0" name="MinSR" units="dimensionless"/>
<variable initial_value="1.75000900000000001e-08" name="O" units="dimensionless"/>
<variable initial_value="2.5" name="HSR" units="dimensionless"/>
<variable initial_value="0.9004965" name="Ca_SR_release_R" units="dimensionless"/>
<variable initial_value="500.0" name="kiCa" units="m3_per_s_per_mol"/>
<variable initial_value="5.0" name="kim" units="becquerel"/>
<variable initial_value="9.67726599999999965e-02" name="RI" units="dimensionless"/>
<variable initial_value="10000.0" name="koCa" units="m6_per_s_per_mol2"/>
<variable name="koSRCa" units="m6_per_s_per_mol2"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca_sub" public_interface="in" units="mM"/>
<variable name="Ca_jsr" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_SRCarel</ci>
<apply>
<times/>
<apply>
<times/>
<ci>ks</ci>
<ci>O</ci>
</apply>
<apply>
<minus/>
<ci>Ca_jsr</ci>
<ci>Ca_sub</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>kCaSR</ci>
<apply>
<minus/>
<ci>MaxSR</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>MaxSR</ci>
<ci>MinSR</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>EC50_SR</ci>
<ci>Ca_jsr</ci>
</apply>
<ci>HSR</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
</apply>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kom</ci>
<ci>I</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<ci>RI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>kiSRCa</ci>
<apply>
<times/>
<ci>kiCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<ci>Ca_SR_release_R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
</apply>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SR_release_R</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kim</ci>
<ci>RI</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
</apply>
<ci>Ca_SR_release_R</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<ci>Ca_SR_release_R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>RI</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kom</ci>
<ci>I</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_sub</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<ci>RI</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kim</ci>
<ci>RI</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_sub</ci>
</apply>
<ci>Ca_SR_release_R</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>koSRCa</ci>
<apply>
<divide/>
<ci>koCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
</math>
</component>
<component name="i_KACh">
<variable name="i_KACh_i_KACh" public_interface="out" units="nA"/>
<variable initial_value="0.00345" name="g_KACh" units="uS"/>
<variable initial_value="0.0" name="ACh_on" units="dimensionless"/>
<variable name="E_K" public_interface="in" units="mV"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="a" public_interface="in" units="dimensionless"/>
<variable name="ACh" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KACh_i_KACh</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>ACh_on</ci>
<ci>g_KACh</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">20.0</cn>
</apply>
<cn cellml:units="mV">20.0</cn>
</apply>
</apply>
</apply>
</apply>
<ci>a</ci>
</apply>
<apply>
<gt/>
<ci>ACh</ci>
<cn cellml:units="mM">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="nA">0.0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="Ca_intracellular_fluxes">
<variable initial_value="5.0" name="P_up_basal" units="mol_per_m3_per_s"/>
<variable name="j_Ca_dif" public_interface="out" units="mol_per_m3_per_s"/>
<variable initial_value="0.04" name="tau_tr" units="second"/>
<variable initial_value="5.46866999999999994e-05" name="tau_dif_Ca" units="second"/>
<variable name="b_up" units="dimensionless"/>
<variable name="j_tr" public_interface="out" units="mol_per_m3_per_s"/>
<variable name="j_up" public_interface="out" units="mol_per_m3_per_s"/>
<variable initial_value="5e-05" name="slope_up" units="mM"/>
<variable initial_value="2.86113000000000003e-04" name="K_up" units="mM"/>
<variable name="P_up" units="mol_per_m3_per_s"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<variable name="ACh" public_interface="in" units="mM"/>
<variable name="Ca_jsr" public_interface="in" units="mM"/>
<variable name="Ca_nsr" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Ca_sub" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_Ca_dif</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_sub</ci>
<ci>Cai</ci>
</apply>
<ci>tau_dif_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>b_up</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.25</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0.0</cn>
</apply>
</piece>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.7</cn>
<ci>ACh</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="mM">9e-05</cn>
<ci>ACh</ci>
</apply>
</apply>
<apply>
<gt/>
<ci>ACh</ci>
<cn cellml:units="mM">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>j_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_nsr</ci>
<ci>Ca_jsr</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>j_up</ci>
<apply>
<divide/>
<ci>P_up</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>Cai</ci>
</apply>
<ci>K_up</ci>
</apply>
<ci>slope_up</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_up</ci>
<apply>
<times/>
<ci>P_up_basal</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>b_up</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Rate_modulation_experiments">
<variable initial_value="0.0" name="ACh" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="Iso_1_uM" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML"/>
</component>
<component name="Ca_dynamics">
<variable initial_value="8.59587700000000057e-05" name="Ca_sub" public_interface="out" units="mM"/>
<variable initial_value="0.669119" name="Ca_nsr" public_interface="out" units="mM"/>
<variable initial_value="1.26704600000000013e-04" name="Cai" public_interface="out" units="mM"/>
<variable initial_value="0.5869378" name="Ca_jsr" public_interface="out" units="mM"/>
<variable name="j_tr" public_interface="in" units="mol_per_m3_per_s"/>
<variable name="j_SRCarel" public_interface="in" units="mol_per_m3_per_s"/>
<variable name="delta_fCQ" public_interface="in" units="becquerel"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="CQ_tot" public_interface="in" units="mM"/>
<variable name="j_up" public_interface="in" units="mol_per_m3_per_s"/>
<variable name="V_jsr" public_interface="in" units="uL"/>
<variable name="V_nsr" public_interface="in" units="uL"/>
<variable name="j_Ca_dif" public_interface="in" units="mol_per_m3_per_s"/>
<variable name="i_CaT_i_CaT" public_interface="in" units="nA"/>
<variable name="CM_tot" public_interface="in" units="mM"/>
<variable name="i_siCa" public_interface="in" units="nA"/>
<variable name="V_sub" public_interface="in" units="uL"/>
<variable name="i_NaCa_i_NaCa" public_interface="in" units="nA"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="delta_fCMs" public_interface="in" units="becquerel"/>
<variable name="V_i" public_interface="in" units="uL"/>
<variable name="delta_fTC" public_interface="in" units="becquerel"/>
<variable name="delta_fTMC" public_interface="in" units="becquerel"/>
<variable name="TC_tot" public_interface="in" units="mM"/>
<variable name="TMC_tot" public_interface="in" units="mM"/>
<variable name="delta_fCMi" public_interface="in" units="becquerel"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_sub</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>j_SRCarel</ci>
<ci>V_jsr</ci>
</apply>
<ci>V_sub</ci>
</apply>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_siCa</ci>
<ci>i_CaT_i_CaT</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>i_NaCa_i_NaCa</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>F</ci>
</apply>
<ci>V_sub</ci>
</apply>
</apply>
<ci>j_Ca_dif</ci>
</apply>
<apply>
<times/>
<ci>CM_tot</ci>
<ci>delta_fCMs</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_nsr</ci>
</apply>
<apply>
<minus/>
<ci>j_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>j_tr</ci>
<ci>V_jsr</ci>
</apply>
<ci>V_nsr</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>j_Ca_dif</ci>
<ci>V_sub</ci>
</apply>
<apply>
<times/>
<ci>j_up</ci>
<ci>V_nsr</ci>
</apply>
</apply>
</apply>
<ci>V_i</ci>
</apply>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<times/>
<ci>CM_tot</ci>
<ci>delta_fCMi</ci>
</apply>
<apply>
<times/>
<ci>TC_tot</ci>
<ci>delta_fTC</ci>
</apply>
</apply>
<apply>
<times/>
<ci>TMC_tot</ci>
<ci>delta_fTMC</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_jsr</ci>
</apply>
<apply>
<minus/>
<ci>j_tr</ci>
<apply>
<plus/>
<ci>j_SRCarel</ci>
<apply>
<times/>
<ci>CQ_tot</ci>
<ci>delta_fCQ</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_Na_h_gate">
<variable name="beta_h" units="becquerel"/>
<variable name="h_infinity" units="dimensionless"/>
<variable name="tau_h" units="second"/>
<variable name="alpha_h" units="becquerel"/>
<variable initial_value="5.20200199999999984e-03" name="h" public_interface="out" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<cn cellml:units="becquerel">2000.0</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">320.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">75.0</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>h_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">69.804</cn>
</apply>
<cn cellml:units="mV">4.4565</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_h</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<ci>alpha_h</ci>
<ci>beta_h</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<times/>
<cn cellml:units="becquerel">20.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.125</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">75.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>h_infinity</ci>
<ci>h</ci>
</apply>
<ci>tau_h</ci>
</apply>
</apply>
</math>
</component>
<component name="i_CaL_dL_gate">
<variable name="adVm" units="mV"/>
<variable name="dL_infinity" units="dimensionless"/>
<variable initial_value="1.40229900000000008e-03" name="dL" public_interface="out" units="dimensionless"/>
<variable name="Iso_shift_dL" units="mV"/>
<variable name="tau_dL" units="second"/>
<variable name="Iso_slope_dL" units="dimensionless"/>
<variable name="alpha_dL" units="becquerel"/>
<variable initial_value="5.854" name="k_dL" units="mV"/>
<variable initial_value="-7.7713" name="V_dL" units="mV"/>
<variable name="beta_dL" units="becquerel"/>
<variable name="bdVm" units="mV"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="Iso_1_uM" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>adVm</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="mV">41.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">41.8</cn>
</apply>
</apply>
</piece>
<piece>
<cn cellml:units="mV">0.0</cn>
<apply>
<eq/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
</piece>
<piece>
<apply>
<minus/>
<cn cellml:units="mV">6.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">6.8</cn>
</apply>
</apply>
</piece>
<otherwise>
<ci>V</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>dL_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<ci>V_dL</ci>
</apply>
<ci>Iso_shift_dL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_dL</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<ci>Iso_slope_dL</ci>
<cn cellml:units="dimensionless">100.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>dL</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>dL_infinity</ci>
<ci>dL</ci>
</apply>
<ci>tau_dL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Iso_shift_dL</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="mV">8.0</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="mV">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_dL</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<ci>alpha_dL</ci>
<ci>beta_dL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Iso_slope_dL</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="dimensionless">27.0</cn>
</apply>
<apply>
<gt/>
<ci>Iso_1_uM</ci>
<cn cellml:units="dimensionless">0.0</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0.0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>alpha_dL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="s2_A_per_g_per_m2">0.02839</cn>
</apply>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="mV">41.8</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="mV">41.8</cn>
</apply>
</apply>
<cn cellml:units="mV">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="s2_A_per_g_per_m2">0.0849</cn>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="mV">6.8</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>adVm</ci>
<cn cellml:units="mV">6.8</cn>
</apply>
</apply>
<cn cellml:units="mV">4.8</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_dL</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="s2_A_per_g_per_m2">0.01143</cn>
<apply>
<plus/>
<ci>bdVm</ci>
<cn cellml:units="mV">1.8</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>bdVm</ci>
<cn cellml:units="mV">1.8</cn>
</apply>
<cn cellml:units="mV">2.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>bdVm</ci>
<piecewise>
<piece>
<apply>
<minus/>
<cn cellml:units="mV">1.80001</cn>
</apply>
<apply>
<eq/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="mV">1.8</cn>
</apply>
</apply>
</piece>
<otherwise>
<ci>V</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<connection>
<map_components component_1="i_Kur" component_2="i_Kur_sKur_gate"/>
<map_variables variable_1="s_Kur" variable_2="s_Kur"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_Kur"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_Kur" component_2="i_Kur_rKur_gate"/>
<map_variables variable_1="r_Kur" variable_2="r_Kur"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Kur"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kur_i_Kur" variable_2="i_Kur_i_Kur"/>
</connection>
<connection>
<map_components component_1="Ca_buffering" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_Na"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_Na"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Na"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na_i_Na" variable_2="i_Na_i_Na"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_Na"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_Na_i_Na" variable_2="i_Na_i_Na"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_CaL_dL_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Ca_intracellular_fluxes"/>
<map_variables variable_1="j_tr" variable_2="j_tr"/>
<map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
<map_variables variable_1="Ca_nsr" variable_2="Ca_nsr"/>
<map_variables variable_1="j_up" variable_2="j_up"/>
<map_variables variable_1="j_Ca_dif" variable_2="j_Ca_dif"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="Ca_SR_release" component_2="Ca_dynamics"/>
<map_variables variable_1="j_SRCarel" variable_2="j_SRCarel"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
<map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
</connection>
<connection>
<map_components component_1="Ca_buffering" component_2="Ca_dynamics"/>
<map_variables variable_1="delta_fCQ" variable_2="delta_fCQ"/>
<map_variables variable_1="CQ_tot" variable_2="CQ_tot"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
<map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="CM_tot" variable_2="CM_tot"/>
<map_variables variable_1="delta_fCMs" variable_2="delta_fCMs"/>
<map_variables variable_1="delta_fTC" variable_2="delta_fTC"/>
<map_variables variable_1="delta_fTMC" variable_2="delta_fTMC"/>
<map_variables variable_1="TC_tot" variable_2="TC_tot"/>
<map_variables variable_1="TMC_tot" variable_2="TMC_tot"/>
<map_variables variable_1="delta_fCMi" variable_2="delta_fCMi"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Kr_pi_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_to_q_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Rate_modulation_experiments" component_2="i_Ks"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Kr_pa_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Ks_n_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_CaL_dL_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Na_m_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ca_SR_release" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="Membrane"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="Nai_concentration"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="i_Ks" component_2="i_Ks_n_gate"/>
<map_variables variable_1="n" variable_2="n"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Ks"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ks_i_Ks" variable_2="i_Ks_i_Ks"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="Rate_modulation_experiments" component_2="i_CaL_dL_gate"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_Na_m_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_CaL_fCa_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Rate_modulation_experiments" component_2="i_CaL"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
</connection>
<connection>
<map_components component_1="Rate_modulation_experiments" component_2="i_Ks_n_gate"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_NaCa"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaCa_i_NaCa" variable_2="i_NaCa_i_NaCa"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_NaCa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_NaCa_i_NaCa" variable_2="i_NaCa_i_NaCa"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="i_NaCa"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
<map_variables variable_1="i_NaCa_i_NaCa" variable_2="i_NaCa_i_NaCa"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_KACh_a_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="i_Na_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
</connection>
<connection>
<map_components component_1="i_Na" component_2="i_Na_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_CaT_fT_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Na_h_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_f"/>
<map_variables variable_1="i_fNa" variable_2="i_fNa"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_CaL"/>
<map_variables variable_1="i_siNa" variable_2="i_siNa"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="Cell_parameters" component_2="Nai_concentration"/>
<map_variables variable_1="V_i" variable_2="V_i"/>
<map_variables variable_1="V_sub" variable_2="V_sub"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="Nai_concentration"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_NaK"/>
<map_variables variable_1="i_NaK_i_NaK" variable_2="i_NaK_i_NaK"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_NaCa"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="Rate_modulation_experiments" component_2="i_NaK"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="Ca_intracellular_fluxes" component_2="Rate_modulation_experiments"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_to_r_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_CaT_dT_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="Ki_concentration"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_CaL"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="i_CaL_fCa_gate"/>
<map_variables variable_1="fCa" variable_2="fCa"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_CaL"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
<map_variables variable_1="i_CaL_i_CaL" variable_2="i_CaL_i_CaL"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_CaL"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_siK" variable_2="i_siK"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="i_CaL_dL_gate"/>
<map_variables variable_1="dL" variable_2="dL"/>
</connection>
<connection>
<map_components component_1="i_CaL" component_2="i_CaL_fL_gate"/>
<map_variables variable_1="fL" variable_2="fL"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Kr"/>
<map_variables variable_1="i_Kr_i_Kr" variable_2="i_Kr_i_Kr"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_f"/>
<map_variables variable_1="i_f_i_f" variable_2="i_f_i_f"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_CaT"/>
<map_variables variable_1="i_CaT_i_CaT" variable_2="i_CaT_i_CaT"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RTONF" variable_2="RTONF"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_NaK"/>
<map_variables variable_1="i_NaK_i_NaK" variable_2="i_NaK_i_NaK"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_KACh"/>
<map_variables variable_1="i_KACh_i_KACh" variable_2="i_KACh_i_KACh"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_SK"/>
<map_variables variable_1="i_SK_i_SK" variable_2="i_SK_i_SK"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_to"/>
<map_variables variable_1="i_to_i_to" variable_2="i_to_i_to"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="i_to_q_gate"/>
<map_variables variable_1="q" variable_2="q"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_to"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_to" component_2="i_to_r_gate"/>
<map_variables variable_1="r" variable_2="r"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_f_y_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Voltage_clamp" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_Ks"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="Nai_concentration" component_2="i_Ks"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_Ks"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_Ks_i_Ks" variable_2="i_Ks_i_Ks"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Kur_sKur_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_Ks_n_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Rate_modulation_experiments" component_2="i_f_y_gate"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
<map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_Kur_rKur_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_Kur"/>
<map_variables variable_1="i_Kur_i_Kur" variable_2="i_Kur_i_Kur"/>
</connection>
<connection>
<map_components component_1="Cell_parameters" component_2="Ki_concentration"/>
<map_variables variable_1="V_i" variable_2="V_i"/>
<map_variables variable_1="V_sub" variable_2="V_sub"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="Membrane"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_Kr"/>
<map_variables variable_1="i_Kr_i_Kr" variable_2="i_Kr_i_Kr"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_f"/>
<map_variables variable_1="i_fK" variable_2="i_fK"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_NaK"/>
<map_variables variable_1="i_NaK_i_NaK" variable_2="i_NaK_i_NaK"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_SK"/>
<map_variables variable_1="i_SK_i_SK" variable_2="i_SK_i_SK"/>
</connection>
<connection>
<map_components component_1="Ki_concentration" component_2="i_to"/>
<map_variables variable_1="i_to_i_to" variable_2="i_to_i_to"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Cell_parameters"/>
<map_variables variable_1="V_jsr" variable_2="V_jsr"/>
<map_variables variable_1="V_nsr" variable_2="V_nsr"/>
<map_variables variable_1="V_sub" variable_2="V_sub"/>
<map_variables variable_1="V_i" variable_2="V_i"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_Kr_pi_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="i_SK_x_gate"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="i_CaL"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
<map_variables variable_1="i_siCa" variable_2="i_siCa"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_Kur_rKur_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_NaK"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_Kr"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_f_y_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_CaL_fL_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_to_q_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_f" component_2="i_f_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_f"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_CaT_dT_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="i_CaT"/>
<map_variables variable_1="i_CaT_i_CaT" variable_2="i_CaT_i_CaT"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="Membrane"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_Kr_pa_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_CaL_fL_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_KACh"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_KACh" component_2="i_KACh_a_gate"/>
<map_variables variable_1="a" variable_2="a"/>
</connection>
<connection>
<map_components component_1="Rate_modulation_experiments" component_2="i_KACh"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="i_KACh_a_gate"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_Na_h_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="i_Kr_pa_gate"/>
<map_variables variable_1="paS" variable_2="paS"/>
<map_variables variable_1="paF" variable_2="paF"/>
</connection>
<connection>
<map_components component_1="i_Kr" component_2="i_Kr_pi_gate"/>
<map_variables variable_1="piy" variable_2="piy"/>
</connection>
<connection>
<map_components component_1="Rate_modulation_experiments" component_2="i_KACh_a_gate"/>
<map_variables variable_1="ACh" variable_2="ACh"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_CaT_fT_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_SK_x_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_to_r_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_dynamics" component_2="i_CaL_fCa_gate"/>
<map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
</connection>
<connection>
<map_components component_1="environment" component_2="i_Kur_sKur_gate"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Membrane" component_2="Voltage_clamp"/>
<map_variables variable_1="V_clamp" variable_2="V_clamp"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_CaT"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="i_CaT_dT_gate"/>
<map_variables variable_1="dT" variable_2="dT"/>
</connection>
<connection>
<map_components component_1="i_CaT" component_2="i_CaT_fT_gate"/>
<map_variables variable_1="fT" variable_2="fT"/>
</connection>
<connection>
<map_components component_1="Ionic_values" component_2="i_SK"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="i_SK" component_2="i_SK_x_gate"/>
<map_variables variable_1="x" variable_2="x"/>
</connection>
</model>
