- Author:
- AnandR <a.rampadarath@auckland.ac.nz>
- Date:
- 2019-04-05 14:25:01+13:00
- Desc:
- Added some semgen annotated models (AnandR)
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/584/rawfile/ade7933153a72bb89e0b02d75db92d6e4be285f5/Strieter_1992_NaK.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="Strieter_1992_NaK" cmeta:id="Strieter_1992_NaK">
<import xlink:href="Units/Units.cellml">
<units name="umol_per_s_per_cm2" units_ref="umol_per_s_per_cm2" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="C_per_mol" units_ref="C_per_mol" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="mM" units_ref="mM" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="mV" units_ref="mV" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="mJ_per_mol_per_kelvin" units_ref="mJ_per_mol_per_kelvin" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="mA_per_cm2" units_ref="mA_per_cm2" />
</import>
<component name="NaK">
<variable cmeta:id="NaK.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="NaK.Na_int" name="Na_int" public_interface="in" units="mM" />
<variable cmeta:id="NaK.Na_ext" name="Na_ext" public_interface="in" units="mM" />
<variable cmeta:id="NaK.K_int" name="K_int" public_interface="in" units="mM" />
<variable cmeta:id="NaK.K_ext" name="K_ext" public_interface="in" units="mM" />
<variable cmeta:id="NaK.K_mNa" initial_value="13" name="K_mNa" units="mM" />
<variable cmeta:id="NaK.K_mK" initial_value="1" name="K_mK" units="mM" />
<variable cmeta:id="NaK.sigma" name="sigma" units="dimensionless" />
<variable cmeta:id="NaK.f_1" name="f_1" units="dimensionless" />
<variable cmeta:id="NaK.F" initial_value="96485" name="F" units="C_per_mol" />
<variable cmeta:id="NaK.R" initial_value="8314.41" name="R" units="mJ_per_mol_per_kelvin" />
<variable cmeta:id="NaK.T" initial_value="300" name="T" units="kelvin" />
<variable cmeta:id="NaK.J_NaK_max" name="J_NaK_max" public_interface="in" units="umol_per_s_per_cm2" />
<variable cmeta:id="NaK.J_NaK" name="J_NaK" public_interface="out" units="umol_per_s_per_cm2" />
<variable cmeta:id="NaK.I_NaK" name="I_NaK" public_interface="out" units="mA_per_cm2" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>sigma</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus />
<apply>
<exp />
<apply>
<divide />
<ci>Na_ext</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>f_1</ci>
<apply>
<power />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.12</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.04</cn>
<ci>sigma</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>J_NaK</ci>
<apply>
<times />
<ci>J_NaK_max</ci>
<apply>
<power />
<apply>
<divide />
<ci>Na_int</ci>
<apply>
<plus />
<ci>Na_int</ci>
<ci>K_mNa</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>K_ext</ci>
<apply>
<plus />
<ci>K_ext</ci>
<ci>K_mK</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>I_NaK</ci>
<apply>
<times />
<ci>f_1</ci>
<ci>F</ci>
<ci>J_NaK</ci>
</apply>
</apply>
</math>
</component>
<rdf:RDF xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#">
<rdf:Description rdf:about="">
<dc:title>A kinetic model of Na+/K+-ATPase (sodium-potassium pump)</dc:title>
</rdf:Description>
<rdf:Description rdf:about="#NaK.Na_int">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<ro:part_of>
<rdf:Description rdf:about="#entity_2">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_15628" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_66836" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in the portion of cytosol in collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NaK.K_ext">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_6">
<ro:part_of>
<rdf:Description rdf:about="#entity_4">
<ro:part_of rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_85358" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the region of mucosa in collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NaK.K_int">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_5">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the portion of cytosol in collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NaK.Na_ext">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_3">
<ro:part_of rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in the region of mucosa in collecting duct of renal tubule compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Strieter_1992_NaK" semsim:unknown="Strieter_1992_NaK" semsim:modelName="Strieter_1992_NaK">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>protein module</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
<rdf:Description rdf:about="#Strieter_1992_NaK" semsim:modelName="Strieter_1992_NaK">
<ro:modelOf rdf:resource="http://purl.obolibrary.org/obo/PR_Q64541" />
<ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_84666" />
<ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_84669" />
<ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_85358" />
<ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_66836" />
<ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_15628" />
<ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_86560" />
<bqmodel:isDescribedBy rdf:resource="https://doi.org/10.1152/ajprenal.1992.263.6.F1063" />
<ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_15628" />
<ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_86560" />
<ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_84666" />
<ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_84666" />
</rdf:Description>
</rdf:RDF>
</model>
