- Author:
- Nima Afshar <nafs080@aucklanduni.ac.nz>
- Date:
- 2019-12-11 15:02:12+13:00
- Desc:
- Generated from Afshar vs Thorsen.cellml
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/572/rawfile/9a05c3e61f90a1645655385440b46a8e6ad078bd/New_Modular_Model.cellml
<?xml version='1.0'?>
<model name="Composite_Model" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units.cellml">
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="uF" units_ref="uF"/>
<units name="m2" units_ref="m2"/>
<units name="m3" units_ref="m3"/>
<units name="m_per_s" units_ref="m_per_s"/>
<units name="per_M2_per_second" units_ref="per_M2_per_second"/>
<units name="per_second" units_ref="per_second"/>
<units name="per_M_per_second" units_ref="per_M_per_second"/>
<units name="M" units_ref="M"/>
<units name="per_M3_per_second5" units_ref="per_M3_per_second5"/>
<units name="M3_per_second" units_ref="M3_per_second"/>
<units name="M_per_second" units_ref="M_per_second"/>
<units name="umol_per_s" units_ref="umol_per_s"/>
<units name="umol" units_ref="umol"/>
<units name="M2" units_ref="M2"/>
<units name="M3" units_ref="M3"/>
<units name="uA" units_ref="uA"/>
<units name="per_meter" units_ref="per_meter"/>
<units name="S" units_ref="S"/>
<units name="S_per_m2" units_ref="S_per_m2"/>
<units name="per_m2" units_ref="per_m2"/>
<units name="cm_per_s" units_ref="cm_per_s"/>
<units name="per_second2" units_ref="per_second2"/>
<units name="per_M4_per_second2" units_ref="per_M4_per_second2"/>
<units name="per_M4_per_second" units_ref="per_M4_per_second"/>
<units name="mole_per_m2" units_ref="mole_per_m2"/>
</import>
<import xlink:href="Parameters.cellml">
<component component_ref="parameters" name="parameters"/>
</import>
<import xlink:href="Apical_Concentration.cellml">
<component component_ref="Apical_concentrations" name="Apical_concentrations"/>
</import>
<import xlink:href="SGLT1_Rate_Constants.cellml">
<component component_ref="SGLT1_rate_constants" name="SGLT1_rate_constants"/>
</import>
<import xlink:href="SGLT1_flux.cellml">
<component component_ref="SGLT1" name="SGLT1"/>
</import>
<import xlink:href="Apical_Voltage.cellml">
<component component_ref="Apical_voltage" name="Apical_voltage"/>
</import>
<import xlink:href="Cell_Concentration.cellml">
<component component_ref="Cell_concentration" name="Cell_concentration"/>
</import>
<import xlink:href="GLUT2_flux.cellml">
<component component_ref="GLUT2" name="GLUT2"/>
</import>
<import xlink:href="Apical_GLUT2_flux.cellml">
<component component_ref="A_GLUT2" name="A_GLUT2"/>
</import>
<import xlink:href="Basolateral_Concentrations.cellml">
<component component_ref="Basolateral_concentrations" name="Basolateral_concentrations"/>
</import>
<!-- def import using "Apical_Diffusion_fluxes.cellml" for
comp Apical_Diffusion using comp Apical_Diffusion;
enddef;-->
<import xlink:href="NaK_flux.cellml">
<component component_ref="NaK_channel" name="NaK_channel"/>
</import>
<import xlink:href="Basol_voltage.cellml">
<component component_ref="Basol_voltage" name="Basol_voltage"/>
</import>
<import xlink:href="Paracellular_Dif_flux.cellml">
<component component_ref="Paracellular_Diffusion" name="Paracellular_Diffusion"/>
</import>
<import xlink:href="Paracellular_Voltage.cellml">
<component component_ref="Paracellular_voltage" name="Paracellular_voltage"/>
</import>
<!-- def import using "Basol_Diffusion_flux.cellml" for
comp Basolateral_Diffusion using comp Basolateral_Diffusion;
enddef;-->
<import xlink:href="BK_flux.cellml">
<component component_ref="BK" name="BK"/>
</import>
<import xlink:href="KCNQ_flux.cellml">
<component component_ref="KCNQ" name="KCNQ"/>
</import>
<import xlink:href="AE1_flux.cellml">
<component component_ref="AE1" name="AE1"/>
</import>
<import xlink:href="NHE3_flux.cellml">
<component component_ref="NHE3" name="NHE3"/>
</import>
<import xlink:href="NBC_flux.cellml">
<component component_ref="NBC" name="NBC"/>
</import>
<import xlink:href="NaKCC_flux.cellml">
<component component_ref="NaKCC" name="NaKCC"/>
</import>
<import xlink:href="ENaC_flux.cellml">
<component component_ref="ENaC" name="ENaC"/>
</import>
<import xlink:href="CFTR_flux.cellml">
<component component_ref="CFTR" name="CFTR"/>
</import>
<import xlink:href="CLC2_flux.cellml">
<component component_ref="CLC2" name="CLC2"/>
</import>
<!-- def import using "interstitium_flux.cellml" for
comp interstitium_concentration using comp interstitium_concentration;
enddef;-->
<!-- def import using "Blood_flux.cellml" for
comp Blood_concentration using comp Blood_concentration;
enddef;-->
<component name="environment">
<!--var V: millivolt {init: -85.0, pub: out};-->
<variable name="time" public_interface="out" units="second"/>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="Enterocyte">
<component_ref component="parameters"/>
<component_ref component="Apical_concentrations"/>
<component_ref component="SGLT1_rate_constants"/>
<component_ref component="SGLT1"/>
<component_ref component="Apical_voltage"/>
<component_ref component="Cell_concentration"/>
<component_ref component="GLUT2"/>
<component_ref component="A_GLUT2"/>
<component_ref component="Basolateral_concentrations"/>
<component_ref component="Basol_voltage"/>
<component_ref component="Paracellular_Diffusion"/>
<component_ref component="Paracellular_voltage"/>
<component_ref component="BK"/>
<component_ref component="KCNQ"/>
<component_ref component="AE1"/>
<component_ref component="NHE3"/>
<component_ref component="NBC"/>
<component_ref component="NaKCC"/>
<component_ref component="ENaC"/>
<component_ref component="CFTR"/>
<component_ref component="CLC2"/>
<!-- comp interstitium_concentration;
comp Blood_concentration;-->
</component_ref>
</group>
<component name="Enterocyte">
<variable name="v_mc" private_interface="in" public_interface="out" units="volt"/>
<variable name="glucose_i" private_interface="in" public_interface="out" units="M"/>
<variable name="glucose_s" private_interface="in" public_interface="out" units="M"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<!--var glucose_B: M {pub: in};-->
<variable name="Na_i" private_interface="in" public_interface="out" units="M"/>
<variable name="Cl_i" private_interface="in" public_interface="out" units="M"/>
<variable name="K_i" private_interface="in" public_interface="out" units="M"/>
<variable name="v_sc" private_interface="in" public_interface="out" units="volt"/>
<variable name="v_ms" private_interface="in" public_interface="out" units="volt"/>
<variable name="H_int" private_interface="in" public_interface="out" units="M"/>
<variable name="HCO3_i" private_interface="in" public_interface="out" units="M"/>
<variable name="pH_int" private_interface="in" public_interface="out" units="per_second"/>
<variable name="pH_Ext" private_interface="in" public_interface="out" units="per_second"/>
</component>
<connection>
<map_components component_1="environment" component_2="Enterocyte"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Cell_concentration" component_2="Enterocyte"/>
<map_variables variable_1="glucose_i" variable_2="glucose_i"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="HCO3_i" variable_2="HCO3_i"/>
<map_variables variable_1="H_int" variable_2="H_int"/>
<map_variables variable_1="pH_int" variable_2="pH_int"/>
<map_variables variable_1="pH_Ext" variable_2="pH_Ext"/>
</connection>
<!-- def map between Apical_concentrations and Enterocyte for
vars time and time;
enddef;-->
<connection>
<map_components component_1="SGLT1_rate_constants" component_2="SGLT1"/>
<map_variables variable_1="ks_12" variable_2="ks_12"/>
<map_variables variable_1="k_12" variable_2="k_12"/>
<map_variables variable_1="k_21" variable_2="k_21"/>
<!--vars k_23 and k_23;-->
<map_variables variable_1="k_32" variable_2="k_32"/>
<map_variables variable_1="k_25" variable_2="k_25"/>
<map_variables variable_1="k_52" variable_2="k_52"/>
<map_variables variable_1="k_34" variable_2="k_34"/>
<map_variables variable_1="k_43" variable_2="k_43"/>
<map_variables variable_1="k_45" variable_2="k_45"/>
<map_variables variable_1="k_54" variable_2="k_54"/>
<map_variables variable_1="k_56" variable_2="k_56"/>
<map_variables variable_1="k_65" variable_2="k_65"/>
<map_variables variable_1="k_61" variable_2="k_61"/>
<map_variables variable_1="k_16" variable_2="k_16"/>
</connection>
<connection>
<map_components component_1="SGLT1" component_2="Apical_concentrations"/>
<map_variables variable_1="Na_m" variable_2="Na_m"/>
<map_variables variable_1="glucose_m" variable_2="glucose_m"/>
</connection>
<connection>
<map_components component_1="SGLT1" component_2="Cell_concentration"/>
<map_variables variable_1="J_Na_SGLT" variable_2="J_Na_SGLT"/>
<map_variables variable_1="J_Gl_SGLT" variable_2="J_Gl_SGLT"/>
</connection>
<connection>
<map_components component_1="SGLT1" component_2="parameters"/>
<map_variables variable_1="k0_23" variable_2="k0_23"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="SGLT1" component_2="Apical_voltage"/>
<map_variables variable_1="I_Na_SGLT" variable_2="I_Na_SGLT"/>
<!--vars I_Gl_SGLT and I_Gl_SGLT;-->
</connection>
<connection>
<map_components component_1="SGLT1_rate_constants" component_2="Apical_concentrations"/>
<map_variables variable_1="Na_m" variable_2="Na_m"/>
<map_variables variable_1="glucose_m" variable_2="glucose_m"/>
</connection>
<connection>
<map_components component_1="SGLT1_rate_constants" component_2="Cell_concentration"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="glucose_i" variable_2="glucose_i"/>
</connection>
<connection>
<map_components component_1="SGLT1_rate_constants" component_2="parameters"/>
<map_variables variable_1="k0_12" variable_2="k0_12"/>
<map_variables variable_1="k0_21" variable_2="k0_21"/>
<!--vars k0_23 and k0_23;-->
<map_variables variable_1="k0_32" variable_2="k0_32"/>
<map_variables variable_1="k0_25" variable_2="k0_25"/>
<map_variables variable_1="k0_52" variable_2="k0_52"/>
<map_variables variable_1="k0_34" variable_2="k0_34"/>
<map_variables variable_1="k0_43" variable_2="k0_43"/>
<map_variables variable_1="k0_45" variable_2="k0_45"/>
<map_variables variable_1="k0_54" variable_2="k0_54"/>
<map_variables variable_1="k0_56" variable_2="k0_56"/>
<map_variables variable_1="k0_65" variable_2="k0_65"/>
<map_variables variable_1="k0_61" variable_2="k0_61"/>
<map_variables variable_1="k0_16" variable_2="k0_16"/>
<map_variables variable_1="delta" variable_2="delta"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<!--vars alpha_pp and alpha_pp;-->
<!--vars C_T and C_T;-->
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="z_c" variable_2="z_c"/>
<map_variables variable_1="z_Na" variable_2="z_Na"/>
<map_variables variable_1="mu" variable_2="mu"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="Apical_voltage"/>
<map_variables variable_1="capacitance" variable_2="capacitance"/>
<!--vars time and time;-->
<map_variables variable_1="v_mc" variable_2="v_mc"/>
</connection>
<connection>
<map_components component_1="Enterocyte" component_2="Apical_voltage"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="v_mc" variable_2="v_mc"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="Cell_concentration"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
<!--vars time and time;-->
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="GLUT2" component_2="parameters"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<!-- def map between interstitium_concentration and GLUT2 for
vars glucose_s and glucose_s;
enddef;-->
<connection>
<map_components component_1="GLUT2" component_2="Cell_concentration"/>
<map_variables variable_1="glucose_i" variable_2="glucose_i"/>
<map_variables variable_1="J_GLUT" variable_2="J_GLUT"/>
</connection>
<connection>
<map_components component_1="A_GLUT2" component_2="parameters"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<connection>
<map_components component_1="Apical_concentrations" component_2="A_GLUT2"/>
<map_variables variable_1="glucose_m" variable_2="glucose_m"/>
</connection>
<connection>
<map_components component_1="A_GLUT2" component_2="Cell_concentration"/>
<map_variables variable_1="glucose_i" variable_2="glucose_i"/>
<map_variables variable_1="J_A_GLUT" variable_2="J_A_GLUT"/>
</connection>
<!-- def map between Apical_Diffusion and Cell_concentration for
vars Cl_i and Cl_i;
vars Na_i and Na_i;
vars K_i and K_i;
vars J_D_Na and J_D_Na;
vars J_D_K and J_D_K;
vars J_D_Cl and J_D_Cl;
enddef;-->
<!-- def map between Apical_Diffusion and Apical_concentrations for
vars Cl_m and Cl_m;
vars Na_m and Na_m;
vars K_m and K_m;
enddef;-->
<!-- def map between Apical_Diffusion and Apical_voltage for
vars I_D_Na and I_D_Na;
vars I_D_K and I_D_K;
vars I_D_Cl and I_D_Cl;
vars v_mc and v_mc;
enddef;-->
<!-- def map between Apical_Diffusion and parameters for
vars F and F;
vars z_Na and z_Na;
vars z_k and z_k;
vars z_Cl and z_Cl;
vars R and R;
vars T and T;
vars A_Apical and A_Apical;
vars P_Na and P_Na;
vars P_k and P_k;
vars P_Cl and P_Cl;
enddef;-->
<connection>
<map_components component_1="NaK_channel" component_2="parameters"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="NaK_channel" component_2="Basolateral_concentrations"/>
<map_variables variable_1="K_s" variable_2="K_s"/>
<map_variables variable_1="J_Na_NaK" variable_2="J_Na_NaK"/>
<map_variables variable_1="J_K_NaK" variable_2="J_K_NaK"/>
</connection>
<connection>
<map_components component_1="NaK_channel" component_2="Cell_concentration"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="J_K_NaK" variable_2="J_K_NaK"/>
<map_variables variable_1="J_Na_NaK" variable_2="J_Na_NaK"/>
</connection>
<connection>
<map_components component_1="Basol_voltage" component_2="NaK_channel"/>
<map_variables variable_1="I_Na_NaK" variable_2="I_Na_NaK"/>
<map_variables variable_1="I_K_NaK" variable_2="I_K_NaK"/>
<map_variables variable_1="v_sc" variable_2="v_sc"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="Basol_voltage"/>
<map_variables variable_1="capacitance" variable_2="capacitance"/>
</connection>
<connection>
<map_components component_1="Enterocyte" component_2="Basol_voltage"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="v_sc" variable_2="v_sc"/>
</connection>
<connection>
<map_components component_1="Enterocyte" component_2="Paracellular_voltage"/>
<map_variables variable_1="v_ms" variable_2="v_ms"/>
</connection>
<connection>
<map_components component_1="Apical_concentrations" component_2="Paracellular_Diffusion"/>
<map_variables variable_1="Na_m" variable_2="Na_m"/>
<map_variables variable_1="K_m" variable_2="K_m"/>
<map_variables variable_1="Cl_m" variable_2="Cl_m"/>
<!--vars F and F;-->
</connection>
<connection>
<map_components component_1="parameters" component_2="Paracellular_Diffusion"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Na" variable_2="z_Na"/>
<map_variables variable_1="z_k" variable_2="z_k"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="P_P_Na" variable_2="P_P_Na"/>
<map_variables variable_1="P_P_k" variable_2="P_P_k"/>
<map_variables variable_1="P_P_Cl" variable_2="P_P_Cl"/>
</connection>
<connection>
<map_components component_1="Paracellular_Diffusion" component_2="Paracellular_voltage"/>
<map_variables variable_1="v_ms" variable_2="v_ms"/>
</connection>
<connection>
<map_components component_1="Basol_voltage" component_2="Paracellular_voltage"/>
<map_variables variable_1="v_sc" variable_2="v_sc"/>
</connection>
<connection>
<map_components component_1="Apical_voltage" component_2="Paracellular_voltage"/>
<map_variables variable_1="v_mc" variable_2="v_mc"/>
</connection>
<connection>
<map_components component_1="Apical_voltage" component_2="Paracellular_Diffusion"/>
<map_variables variable_1="I_D_P_Na" variable_2="I_D_P_Na"/>
<map_variables variable_1="I_D_P_K" variable_2="I_D_P_K"/>
<map_variables variable_1="I_D_P_Cl" variable_2="I_D_P_Cl"/>
</connection>
<connection>
<map_components component_1="Basol_voltage" component_2="Paracellular_Diffusion"/>
<map_variables variable_1="I_D_P_Na" variable_2="I_D_P_Na"/>
<map_variables variable_1="I_D_P_K" variable_2="I_D_P_K"/>
<map_variables variable_1="I_D_P_Cl" variable_2="I_D_P_Cl"/>
</connection>
<connection>
<map_components component_1="Basolateral_concentrations" component_2="Paracellular_Diffusion"/>
<map_variables variable_1="Na_s" variable_2="Na_s"/>
<map_variables variable_1="K_s" variable_2="K_s"/>
<map_variables variable_1="Cl_s" variable_2="Cl_s"/>
<map_variables variable_1="J_D_P_Na" variable_2="J_D_P_Na"/>
<map_variables variable_1="J_D_P_K" variable_2="J_D_P_K"/>
<map_variables variable_1="J_D_P_Cl" variable_2="J_D_P_Cl"/>
<!--vars F and F;-->
</connection>
<!-- def map between Cell_concentration and Basolateral_Diffusion for
vars Na_i and Na_i;
vars K_i and K_i;
vars Cl_i and Cl_i;
vars J_D_Bl_Na and J_D_Bl_Na;
vars J_D_Bl_K and J_D_Bl_K;
vars J_D_Bl_Cl and J_D_Bl_Cl;
enddef;-->
<!-- def map between Basolateral_Diffusion and Basol_voltage for
vars I_D_Bl_Na and I_D_Bl_Na;
vars I_D_Bl_K and I_D_Bl_K;
vars I_D_Bl_Cl and I_D_Bl_Cl;
vars v_sc and v_sc;
enddef;-->
<!-- def map between Basolateral_concentrations and Basolateral_Diffusion for
vars Na_s and Na_s;
vars K_s and K_s;
vars Cl_s and Cl_s;-->
<!-- //vars F and F;
enddef;-->
<!-- def map between parameters and Basolateral_Diffusion for
vars F and F;
vars z_Na and z_Na;
vars z_k and z_k;
vars z_Cl and z_Cl;
vars R and R;
vars T and T;
vars A_Basol and A_Basol;
vars P_Bl_Na and P_Bl_Na;
vars P_Bl_k and P_Bl_k;
vars P_Bl_Cl and P_Bl_Cl;
enddef;-->
<connection>
<map_components component_1="BK" component_2="parameters"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_k" variable_2="z_k"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="BK" component_2="Cell_concentration"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="J_BK" variable_2="J_BK"/>
</connection>
<connection>
<map_components component_1="BK" component_2="Apical_concentrations"/>
<map_variables variable_1="K_m" variable_2="K_m"/>
</connection>
<connection>
<map_components component_1="BK" component_2="Apical_voltage"/>
<map_variables variable_1="v_mc" variable_2="v_mc"/>
<map_variables variable_1="I_BK" variable_2="I_BK"/>
</connection>
<connection>
<map_components component_1="KCNQ" component_2="parameters"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_k" variable_2="z_k"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="KCNQ" component_2="Cell_concentration"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="J_KCNQ" variable_2="J_KCNQ"/>
</connection>
<connection>
<map_components component_1="KCNQ" component_2="Basolateral_concentrations"/>
<map_variables variable_1="K_s" variable_2="K_s"/>
<map_variables variable_1="J_KCNQ" variable_2="J_KCNQ"/>
</connection>
<connection>
<map_components component_1="KCNQ" component_2="Basol_voltage"/>
<map_variables variable_1="v_sc" variable_2="v_sc"/>
<map_variables variable_1="I_KCNQ" variable_2="I_KCNQ"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="AE1"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
<!--vars A_Apical and A_Apical;-->
</connection>
<connection>
<map_components component_1="Cell_concentration" component_2="AE1"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="HCO3_i" variable_2="HCO3_i"/>
<map_variables variable_1="HCO3_m" variable_2="HCO3_m"/>
<map_variables variable_1="J_AE1_Cl" variable_2="J_AE1_Cl"/>
<map_variables variable_1="J_AE1_HCO3" variable_2="J_AE1_HCO3"/>
</connection>
<connection>
<map_components component_1="Apical_concentrations" component_2="AE1"/>
<map_variables variable_1="Cl_m" variable_2="Cl_m"/>
</connection>
<connection>
<map_components component_1="Cell_concentration" component_2="NHE3"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="H_int" variable_2="H_int"/>
<map_variables variable_1="H_Ext" variable_2="H_Ext"/>
<!-- vars HCO3_i and HCO3_i;
vars HCO3_m and HCO3_m;-->
<!-- vars Cl_i and Cl_i;-->
<map_variables variable_1="J_NHE3_Na" variable_2="J_NHE3_Na"/>
<map_variables variable_1="J_NHE3_H" variable_2="J_NHE3_H"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="NHE3"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
<!-- vars time and time;
vars R and R;
vars T and T;-->
</connection>
<!-- def map between Apical_voltage and NHE3 for
//vars v_sc and v_sc;-->
<!-- vars I_NHE3_H and I_NHE3_H;
vars I_NHE3_Na and I_NHE3_Na;
enddef;-->
<connection>
<map_components component_1="Apical_concentrations" component_2="NHE3"/>
<map_variables variable_1="Na_m" variable_2="Na_m"/>
</connection>
<connection>
<map_components component_1="Cell_concentration" component_2="NBC"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<!-- vars Cl_i and Cl_i;-->
<map_variables variable_1="J_NBC_Na" variable_2="J_NBC_Na"/>
<map_variables variable_1="J_NBC_HCO3" variable_2="J_NBC_HCO3"/>
<map_variables variable_1="HCO3_i" variable_2="HCO3_i"/>
<map_variables variable_1="HCO3_s" variable_2="HCO3_s"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="NBC"/>
<map_variables variable_1="F" variable_2="F"/>
<!--vars time and time;-->
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<!-- def map between main and NBC for
vars time and time;
enddef;-->
<connection>
<map_components component_1="Basol_voltage" component_2="NBC"/>
<map_variables variable_1="v_sc" variable_2="v_sc"/>
<map_variables variable_1="I_NBC_HCO3" variable_2="I_NBC_HCO3"/>
<map_variables variable_1="I_NBC_Na" variable_2="I_NBC_Na"/>
</connection>
<connection>
<map_components component_1="Basolateral_concentrations" component_2="NBC"/>
<map_variables variable_1="Na_s" variable_2="Na_s"/>
<map_variables variable_1="J_NBC_Na" variable_2="J_NBC_Na"/>
</connection>
<connection>
<map_components component_1="NaKCC" component_2="Cell_concentration"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="J_NaKCC" variable_2="J_NaKCC"/>
</connection>
<connection>
<map_components component_1="NaKCC" component_2="parameters"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="ENaC" component_2="parameters"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Na" variable_2="z_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="ENaC" component_2="Cell_concentration"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="J_ENaC" variable_2="J_ENaC"/>
</connection>
<connection>
<map_components component_1="ENaC" component_2="Apical_concentrations"/>
<map_variables variable_1="Na_m" variable_2="Na_m"/>
</connection>
<connection>
<map_components component_1="ENaC" component_2="Apical_voltage"/>
<map_variables variable_1="v_mc" variable_2="v_mc"/>
<map_variables variable_1="I_ENaC" variable_2="I_ENaC"/>
</connection>
<connection>
<map_components component_1="CFTR" component_2="parameters"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="CFTR" component_2="Cell_concentration"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="J_CFTR" variable_2="J_CFTR"/>
</connection>
<connection>
<map_components component_1="CFTR" component_2="Apical_concentrations"/>
<map_variables variable_1="Cl_m" variable_2="Cl_m"/>
</connection>
<connection>
<map_components component_1="CFTR" component_2="Apical_voltage"/>
<map_variables variable_1="v_mc" variable_2="v_mc"/>
<map_variables variable_1="I_CFTR" variable_2="I_CFTR"/>
<!--vars I_CFTR_HCO3 and I_CFTR_HCO3;-->
</connection>
<connection>
<map_components component_1="CLC2" component_2="parameters"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="CLC2" component_2="Cell_concentration"/>
<map_variables variable_1="Cl_i" variable_2="Cl_i"/>
<map_variables variable_1="J_CLC2" variable_2="J_CLC2"/>
</connection>
<connection>
<map_components component_1="CLC2" component_2="Basolateral_concentrations"/>
<map_variables variable_1="Cl_s" variable_2="Cl_s"/>
<map_variables variable_1="J_CLC2" variable_2="J_CLC2"/>
</connection>
<connection>
<map_components component_1="CLC2" component_2="Basol_voltage"/>
<map_variables variable_1="v_sc" variable_2="v_sc"/>
<map_variables variable_1="I_CLC2" variable_2="I_CLC2"/>
</connection>
<connection>
<map_components component_1="Basolateral_concentrations" component_2="GLUT2"/>
<map_variables variable_1="glucose_s" variable_2="glucose_s"/>
<map_variables variable_1="J_GLUT" variable_2="J_GLUT"/>
<!--vars J_GLUT and J_GLUT;-->
</connection>
<connection>
<map_components component_1="Basolateral_concentrations" component_2="parameters"/>
<!--vars time and time;-->
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<connection>
<map_components component_1="Basolateral_concentrations" component_2="Enterocyte"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="glucose_s" variable_2="glucose_s"/>
</connection>
<connection>
<map_components component_1="Basolateral_concentrations" component_2="NaKCC"/>
<map_variables variable_1="J_NaKCC" variable_2="J_NaKCC"/>
</connection>
<!-- def map between interstitium_concentration and Blood_concentration for
//vars J_G_Blood and J_G_Blood;-->
<!-- vars glucose_s and glucose_s;
enddef;-->
<!-- def map between Enterocyte and Blood_concentration for
vars time and time;-->
<!-- //vars glucose_B and glucose_B;
enddef;-->
</model>
