- Author:
- AnandR <a.rampadarath@auckland.ac.nz>
- Date:
- 2018-12-14 16:04:47+13:00
- Desc:
- Annotated models using Semgen
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/55c/rawfile/a471aae70edb5e9f955c60046d52c99d87e69b44/Pandit_et_al_2001_endo.cellml
<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xml:base="file:///H:/terkildsen_niederer_crampin_hunter_smith_2008/Pandit_et_al_2001_endo.cellml" cmeta:id="pandit_et_al_2001_endo" name="pandit_et_al_2001_endo">
<units name="per_second">
<unit exponent="-1" units="second"/>
</units>
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_millivolt">
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<units name="per_millivolt2">
<unit exponent="-2" prefix="milli" units="volt"/>
</units>
<units name="microS">
<unit prefix="micro" units="siemens"/>
</units>
<units name="microF">
<unit prefix="micro" units="farad"/>
</units>
<units name="nanoA">
<unit prefix="nano" units="ampere"/>
</units>
<units name="nanoA_per_millimolar_4">
<unit prefix="nano" units="ampere"/>
<unit exponent="-4" units="millimolar"/>
</units>
<units name="millimolar">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="per_millimolar_per_second">
<unit exponent="-1" units="millimolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="millimolar_per_second">
<unit units="millimolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="millimolar3_per_second">
<unit exponent="-3" units="millimolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="millimolar4_per_second">
<unit exponent="-4" units="millimolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="millimolar_4">
<unit exponent="-4" units="millimolar"/>
</units>
<units name="millijoule_per_mole_kelvin">
<unit prefix="milli" units="joule"/>
<unit exponent="-1" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="micro_litre">
<unit prefix="micro" units="litre"/>
</units>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="membrane">
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<variable initial_value="8314.5" name="R" public_interface="out" units="millijoule_per_mole_kelvin"/>
<variable initial_value="295" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96487" name="F" public_interface="out" units="coulomb_per_mole"/>
<variable initial_value="0.0001" name="Cm" units="microF"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="i_Na" public_interface="in" units="nanoA"/>
<variable name="i_Ca_L" public_interface="in" units="nanoA"/>
<variable name="i_t" public_interface="in" units="nanoA"/>
<variable name="i_ss" public_interface="in" units="nanoA"/>
<variable name="i_f" public_interface="in" units="nanoA"/>
<variable name="i_K1" public_interface="in" units="nanoA"/>
<variable name="i_B" public_interface="in" units="nanoA"/>
<variable name="i_NaK" public_interface="in" units="nanoA"/>
<variable name="i_NaCa" public_interface="in" units="nanoA"/>
<variable name="i_Ca_P" public_interface="in" units="nanoA"/>
<variable name="i_Stim" public_interface="out" units="nanoA"/>
<variable name="stim_period" units="second"/>
<variable initial_value="5e-3" name="stim_duration" units="second"/>
<variable initial_value="-0.6" name="stim_amplitude" units="nanoA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
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<and/>
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<geq/>
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<leq/>
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</apply>
</apply>
</piece>
<otherwise>
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</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_Stim</ci>
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<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<apply>
<minus/>
<ci>time</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
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<ci>stim_period</ci>
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<ci>stim_period</ci>
</apply>
</apply>
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</apply>
<apply>
<leq/>
<apply>
<minus/>
<ci>time</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
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<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>stim_duration</ci>
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</apply>
</apply>
</apply>
</piece>
<otherwise>
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</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_Ca_L</ci>
<ci>i_t</ci>
<ci>i_ss</ci>
<ci>i_f</ci>
<ci>i_K1</ci>
<ci>i_B</ci>
<ci>i_NaK</ci>
<ci>i_NaCa</ci>
<ci>i_Ca_P</ci>
<ci>i_Stim</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00001" name="sodium_current">
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<variable cmeta:id="id_00003" name="E_Na" public_interface="out" units="millivolt"/>
<variable cmeta:id="id_00004" initial_value="0.8" name="g_Na" units="microS"/>
<variable cmeta:id="id_00005" name="g_Na_endo" units="microS"/>
<variable cmeta:id="id_00006" name="Na_i" public_interface="in" units="millimolar"/>
<variable cmeta:id="id_00007" name="Na_o" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="millijoule_per_mole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
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<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="m" private_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" units="dimensionless"/>
<variable name="j" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<times/>
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<eq/>
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<times/>
<apply>
<divide/>
<apply>
<times/>
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<ci>T</ci>
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<ci>F</ci>
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<apply>
<ln/>
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<divide/>
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<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
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<eq/>
<ci>i_Na</ci>
<apply>
<times/>
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<apply>
<power/>
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</apply>
<ci>h</ci>
<ci>j</ci>
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<minus/>
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<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
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<variable name="tau_m" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>m_infinity</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_m</ci>
<apply>
<divide/>
<cn cellml:units="second">0.00136</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
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<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47.13</cn>
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<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
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<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.08</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
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<cn cellml:units="millivolt">11</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>m_infinity</ci>
<ci>m</ci>
</apply>
<ci>tau_m</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00009" name="sodium_current_h_gate">
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<variable name="h_infinity" units="dimensionless"/>
<variable name="tau_h" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>h_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">76.1</cn>
</apply>
<cn cellml:units="millivolt">6.07</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_h</ci>
<piecewise>
<piece>
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<times/>
<cn cellml:units="second">0.0004537</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.66</cn>
</apply>
</apply>
<cn cellml:units="millivolt">11.1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<geq/>
<ci>V</ci>
<apply>
<minus/>
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</apply>
</apply>
</piece>
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<divide/>
<cn cellml:units="second">0.00349</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.135</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.56</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.079</cn>
<ci>V</ci>
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</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">310000</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.35</cn>
<ci>V</ci>
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</apply>
</apply>
</apply>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<divide/>
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<minus/>
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<ci>tau_h</ci>
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<divide/>
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<plus/>
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<divide/>
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<plus/>
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<times/>
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<plus/>
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<exp/>
<apply>
<times/>
<apply>
<minus/>
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<ci>V</ci>
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<geq/>
<ci>V</ci>
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<minus/>
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</apply>
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<times/>
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<divide/>
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<plus/>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
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</apply>
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<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
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<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2444</cn>
<ci>V</ci>
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</apply>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.00003474</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
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<ci>V</ci>
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<divide/>
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<times/>
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<exp/>
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<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.01052</cn>
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<plus/>
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<times/>
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<minus/>
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<plus/>
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</apply>
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<eq/>
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<diff/>
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<divide/>
<apply>
<minus/>
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<eq/>
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<plus/>
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<divide/>
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<minus/>
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</apply>
</apply>
</apply>
</math>
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<divide/>
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<plus/>
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</apply>
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</apply>
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<plus/>
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<times/>
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<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt2">0.0045</cn>
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<power/>
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<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt2">0.002</cn>
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<apply>
<power/>
<apply>
<minus/>
<ci>V</ci>
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<cn cellml:units="dimensionless">2</cn>
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</apply>
</apply>
</apply>
<cn cellml:units="second">0.00025</cn>
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<apply>
<eq/>
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<diff/>
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<minus/>
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</apply>
<ci>tau_d</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00019" name="L_type_Ca_channel_f_11_gate">
<variable initial_value="0.9999529" name="f_11" public_interface="out" units="dimensionless"/>
<variable name="f_11_infinity" units="dimensionless"/>
<variable name="tau_f_11" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_11_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.7</cn>
</apply>
<cn cellml:units="millivolt">5.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_11</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">0.105</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45</cn>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.04</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.015</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0017</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_11</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_11_infinity</ci>
<ci>f_11</ci>
</apply>
<ci>tau_f_11</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00020" name="L_type_Ca_channel_f_12_gate">
<variable initial_value="0.9999529" name="f_12" public_interface="out" units="dimensionless"/>
<variable name="f_12_infinity" units="dimensionless"/>
<variable name="tau_f_12" units="second"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_12_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.7</cn>
</apply>
<cn cellml:units="millivolt">5.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_12</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">0.041</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47</cn>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.08</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">55</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="second">0.015</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0017</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_12</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_12_infinity</ci>
<ci>f_12</ci>
</apply>
<ci>tau_f_12</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00021" name="L_type_Ca_channel_Ca_inact_gate">
<variable initial_value="0.9913102" name="Ca_inact" public_interface="out" units="dimensionless"/>
<variable initial_value="0.009" name="tau_Ca_inact" units="second"/>
<variable name="Ca_inact_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca_ss" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Ca_inact_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_ss</ci>
<cn cellml:units="millimolar">0.01</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_inact</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_inact_infinity</ci>
<ci>Ca_inact</ci>
</apply>
<ci>tau_Ca_inact</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00022" name="Ca_independent_transient_outward_K_current">
<variable name="i_t" public_interface="out" units="nanoA"/>
<variable name="E_K" public_interface="out" units="millivolt"/>
<variable initial_value="0.035" name="g_t" units="microS"/>
<variable name="g_t_endo" units="microS"/>
<variable initial_value="0.583" name="a_endo" units="dimensionless"/>
<variable initial_value="0.417" name="b_endo" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="millijoule_per_mole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="K_o" public_interface="in" units="millimolar"/>
<variable name="K_i" public_interface="in" units="millimolar"/>
<variable name="r" private_interface="in" units="dimensionless"/>
<variable name="s" private_interface="in" units="dimensionless"/>
<variable name="s_slow" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_t_endo</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.4647</cn>
<ci>g_t</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_t</ci>
<apply>
<times/>
<ci>g_t_endo</ci>
<ci>r</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>a_endo</ci>
<ci>s</ci>
</apply>
<apply>
<times/>
<ci>b_endo</ci>
<ci>s_slow</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00023" name="Ca_independent_transient_outward_K_current_r_gate">
<variable initial_value="0.002191519" name="r" public_interface="out" units="dimensionless"/>
<variable name="tau_r" units="second"/>
<variable name="r_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.6</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">11.42</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">45.16</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03577</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00024" name="Ca_independent_transient_outward_K_current_s_gate">
<variable initial_value="0.9842542" name="s" public_interface="out" units="dimensionless"/>
<variable name="tau_s_endo" units="second"/>
<variable name="s_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.3</cn>
</apply>
<cn cellml:units="millivolt">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_endo</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">0.55</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">70</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.049</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_infinity</ci>
<ci>s</ci>
</apply>
<ci>tau_s_endo</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00025" name="Ca_independent_transient_outward_K_current_s_slow_gate">
<variable initial_value="0.6421196" name="s_slow" public_interface="out" units="dimensionless"/>
<variable name="tau_s_slow_endo" units="second"/>
<variable name="s_slow_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_slow_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.3</cn>
</apply>
<cn cellml:units="millivolt">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_slow_endo</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">3.3</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">70</cn>
</apply>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">70</cn>
</apply>
</apply>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.049</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_slow</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_slow_infinity</ci>
<ci>s_slow</ci>
</apply>
<ci>tau_s_slow_endo</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00026" name="steady_state_outward_K_current">
<variable cmeta:id="id_00029" name="i_ss" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00030" initial_value="0.007" name="g_ss" units="microS"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="r_ss" private_interface="in" units="dimensionless"/>
<variable name="s_ss" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_ss</ci>
<apply>
<times/>
<ci>g_ss</ci>
<ci>r_ss</ci>
<ci>s_ss</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00027" name="steady_state_outward_K_current_r_ss_gate">
<variable initial_value="0.002907171" name="r_ss" public_interface="out" units="dimensionless"/>
<variable name="tau_r_ss" units="second"/>
<variable name="r_ss_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_ss_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">11.5</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">11.82</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r_ss</ci>
<apply>
<divide/>
<cn cellml:units="second">10</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">45.16</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03577</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_ss_infinity</ci>
<ci>r_ss</ci>
</apply>
<ci>tau_r_ss</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00028" name="steady_state_outward_K_current_s_ss_gate">
<variable initial_value="0.3142767" name="s_ss" public_interface="out" units="dimensionless"/>
<variable name="tau_s_ss" units="second"/>
<variable name="s_ss_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_ss_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">87.5</cn>
</apply>
<cn cellml:units="millivolt">10.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_ss</ci>
<cn cellml:units="second">2.1</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_ss_infinity</ci>
<ci>s_ss</ci>
</apply>
<ci>tau_s_ss</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00031" name="inward_rectifier">
<variable cmeta:id="id_00032" name="i_K1" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00033" initial_value="0.024" name="g_K1" units="microS"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="millijoule_per_mole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="K_o" public_interface="in" units="millimolar"/>
<variable name="K_i" public_interface="in" units="millimolar"/>
<variable cmeta:id="id_00034" name="E_K" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="nanoA">48</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37</cn>
</apply>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">25</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="nanoA">10</cn>
</apply>
<cn cellml:units="dimensionless">0.001</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">76.77</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.613</cn>
<ci>F</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>K_o</ci>
<cn cellml:units="millimolar">0.9988</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millimolar">0.124</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current">
<variable name="i_f" public_interface="out" units="nanoA"/>
<variable name="i_f_Na" public_interface="out" units="nanoA"/>
<variable name="i_f_K" public_interface="out" units="nanoA"/>
<variable initial_value="0.00145" name="g_f" units="microS"/>
<variable initial_value="0.2" name="f_Na" units="dimensionless"/>
<variable name="f_K" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="second"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="E_Na" public_interface="in" units="millivolt"/>
<variable name="y" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_K</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>f_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_Na</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>y</ci>
<ci>f_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_K</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>y</ci>
<ci>f_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f</ci>
<apply>
<plus/>
<ci>i_f_Na</ci>
<ci>i_f_K</ci>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current_y_gate">
<variable initial_value="0.003578708" name="y" public_interface="out" units="dimensionless"/>
<variable name="tau_y" units="second"/>
<variable name="y_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">138.6</cn>
</apply>
<cn cellml:units="millivolt">10.48</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.11885</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
<cn cellml:units="millivolt">28.37</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5623</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">14.19</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00041" name="background_currents">
<variable cmeta:id="id_00042" name="i_B" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00011" name="i_B_Na" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00035" name="i_B_Ca" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00036" name="i_B_K" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00012" initial_value="0.00008015" name="g_B_Na" units="microS"/>
<variable cmeta:id="id_00037" initial_value="0.0000324" name="g_B_Ca" units="microS"/>
<variable cmeta:id="id_00038" initial_value="0.000138" name="g_B_K" units="microS"/>
<variable cmeta:id="id_00039" initial_value="65" name="E_Ca" units="millivolt"/>
<variable cmeta:id="id_00013" name="E_Na" public_interface="in" units="millivolt"/>
<variable cmeta:id="id_00040" name="E_K" public_interface="in" units="millivolt"/>
<variable name="Ca_o" public_interface="in" units="millimolar"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="millijoule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="V" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>g_B_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_Ca</ci>
<apply>
<times/>
<ci>g_B_Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_K</ci>
<apply>
<times/>
<ci>g_B_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B</ci>
<apply>
<plus/>
<ci>i_B_Na</ci>
<ci>i_B_Ca</ci>
<ci>i_B_K</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00043" name="sodium_potassium_pump">
<variable cmeta:id="id_00044" name="i_NaK" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00045" initial_value="0.08" name="i_NaK_max" units="nanoA"/>
<variable initial_value="1.5" name="K_m_K" units="millimolar"/>
<variable initial_value="10" name="K_m_Na" units="millimolar"/>
<variable name="sigma" units="dimensionless"/>
<variable name="K_o" public_interface="in" units="millimolar"/>
<variable name="Na_o" public_interface="in" units="millimolar"/>
<variable name="Na_i" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="millijoule_per_mole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="V" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Na_o</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaK_max</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>K_m_K</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_m_Na</ci>
<ci>Na_i</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00046" name="sarcolemmal_calcium_pump_current">
<variable cmeta:id="id_00047" name="i_Ca_P" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00048" initial_value="0.004" name="i_Ca_P_max" units="nanoA"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_P</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_Ca_P_max</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0004</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00049" name="Na_Ca_ion_exchanger_current">
<variable cmeta:id="id_00050" name="i_NaCa" public_interface="out" units="nanoA"/>
<variable cmeta:id="id_00051" initial_value="0.000009984" name="K_NaCa" units="nanoA_per_millimolar_4"/>
<variable cmeta:id="id_00052" initial_value="0.0001" name="d_NaCa" units="millimolar_4"/>
<variable cmeta:id="id_00053" initial_value="0.5" name="gamma_NaCa" units="dimensionless"/>
<variable name="Na_i" public_interface="in" units="millimolar"/>
<variable name="Na_o" public_interface="in" units="millimolar"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="Ca_o" public_interface="in" units="millimolar"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_NaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03743</cn>
<ci>V</ci>
<ci>gamma_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03743</cn>
<ci>V</ci>
<apply>
<minus/>
<ci>gamma_NaCa</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00054" name="SR_Ca_release_channel">
<variable name="J_rel" public_interface="out" units="millimolar_per_second"/>
<variable initial_value="1.8e3" name="v1" units="per_second"/>
<variable initial_value="12.15e12" name="k_a_plus" units="millimolar4_per_second"/>
<variable initial_value="576" name="k_a_minus" units="per_second"/>
<variable initial_value="4.05e9" name="k_b_plus" units="millimolar3_per_second"/>
<variable initial_value="1930" name="k_b_minus" units="per_second"/>
<variable initial_value="100" name="k_c_plus" units="per_second"/>
<variable initial_value="0.8" name="k_c_minus" units="per_second"/>
<variable initial_value="0.0004327548" name="P_O1" units="dimensionless"/>
<variable initial_value="0.000000000606254" name="P_O2" units="dimensionless"/>
<variable initial_value="0.6348229" name="P_C1" units="dimensionless"/>
<variable initial_value="0.3647471" name="P_C2" units="dimensionless"/>
<variable initial_value="4" name="n" units="dimensionless"/>
<variable initial_value="3" name="m" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca_ss" public_interface="in" units="millimolar"/>
<variable name="Ca_JSR" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>k_a_plus</ci>
</apply>
<apply>
<power/>
<ci>Ca_ss</ci>
<ci>n</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<times/>
<ci>k_a_minus</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O1</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_a_plus</ci>
<apply>
<power/>
<ci>Ca_ss</ci>
<ci>n</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>k_a_minus</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_b_plus</ci>
<apply>
<power/>
<ci>Ca_ss</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_c_plus</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>k_b_minus</ci>
<ci>P_O2</ci>
</apply>
<apply>
<times/>
<ci>k_c_minus</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_b_plus</ci>
<apply>
<power/>
<ci>Ca_ss</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_b_minus</ci>
<ci>P_O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_c_plus</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_c_minus</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_rel</ci>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>P_O1</ci>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<ci>Ca_JSR</ci>
<ci>Ca_ss</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00055" name="SERCA2a_pump">
<variable name="J_up" public_interface="out" units="millimolar_per_second"/>
<variable initial_value="0.000168" name="K_fb" units="millimolar"/>
<variable initial_value="3.29" name="K_rb" units="millimolar"/>
<variable name="fb" units="dimensionless"/>
<variable name="rb" units="dimensionless"/>
<variable initial_value="0.04" name="Vmaxf" units="millimolar_per_second"/>
<variable initial_value="0.9" name="Vmaxr" units="millimolar_per_second"/>
<variable initial_value="1" name="K_SR" units="dimensionless"/>
<variable initial_value="1.2" name="N_fb" units="dimensionless"/>
<variable initial_value="1" name="N_rb" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="Ca_NSR" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_i</ci>
<ci>K_fb</ci>
</apply>
<ci>N_fb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>rb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_NSR</ci>
<ci>K_rb</ci>
</apply>
<ci>N_rb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>K_SR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Vmaxf</ci>
<ci>fb</ci>
</apply>
<apply>
<times/>
<ci>Vmaxr</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fb</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00056" name="intracellular_and_SR_Ca_fluxes">
<variable name="J_tr" public_interface="out" units="millimolar_per_second"/>
<variable name="J_xfer" public_interface="out" units="millimolar_per_second"/>
<variable name="J_trpn" public_interface="out" units="millimolar_per_second"/>
<variable initial_value="0.0005747" name="tau_tr" units="second"/>
<variable initial_value="0.0267" name="tau_xfer" units="second"/>
<variable initial_value="1.394301e-1" name="HTRPNCa" units="millimolar"/>
<variable initial_value="5.1619e-3" name="LTRPNCa" units="millimolar"/>
<variable name="J_HTRPNCa" units="millimolar_per_second"/>
<variable name="J_LTRPNCa" units="millimolar_per_second"/>
<variable initial_value="0.14" name="HTRPN_tot" units="millimolar"/>
<variable initial_value="0.07" name="LTRPN_tot" units="millimolar"/>
<variable initial_value="200000" name="k_htrpn_plus" units="per_millimolar_per_second"/>
<variable initial_value="0.066" name="k_htrpn_minus" units="per_second"/>
<variable initial_value="40000" name="k_ltrpn_plus" units="per_millimolar_per_second"/>
<variable initial_value="40" name="k_ltrpn_minus" units="per_second"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="Ca_ss" public_interface="in" units="millimolar"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="Ca_NSR" public_interface="in" units="millimolar"/>
<variable name="Ca_JSR" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_NSR</ci>
<ci>Ca_JSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_xfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_ss</ci>
<ci>Ca_i</ci>
</apply>
<ci>tau_xfer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_HTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_htrpn_plus</ci>
<ci>Ca_i</ci>
<apply>
<minus/>
<ci>HTRPN_tot</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_htrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>J_HTRPNCa</ci>
</apply>
<apply>
<eq/>
<ci>J_LTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_ltrpn_plus</ci>
<ci>Ca_i</ci>
<apply>
<minus/>
<ci>LTRPN_tot</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_ltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>J_LTRPNCa</ci>
</apply>
<apply>
<eq/>
<ci>J_trpn</ci>
<apply>
<plus/>
<ci>J_HTRPNCa</ci>
<ci>J_LTRPNCa</ci>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00057" name="intracellular_ion_concentrations">
<variable initial_value="10.73519" name="Na_i" public_interface="out" units="millimolar"/>
<variable initial_value="0.00007901351" name="Ca_i" public_interface="out" units="millimolar"/>
<variable initial_value="139.2751" name="K_i" public_interface="out" units="millimolar"/>
<variable initial_value="0.00008737212" name="Ca_ss" public_interface="out" units="millimolar"/>
<variable initial_value="0.06607948" name="Ca_JSR" public_interface="out" units="millimolar"/>
<variable initial_value="0.06600742" name="Ca_NSR" public_interface="out" units="millimolar"/>
<variable initial_value="9.36e-6" name="V_myo" units="micro_litre"/>
<variable initial_value="0.056e-6" name="V_JSR" units="micro_litre"/>
<variable initial_value="0.504e-6" name="V_NSR" units="micro_litre"/>
<variable initial_value="1.2e-9" name="V_SS" units="micro_litre"/>
<variable cmeta:id="id_00058" initial_value="0.00238" name="K_mCMDN" units="millimolar"/>
<variable cmeta:id="id_00059" initial_value="0.8" name="K_mCSQN" units="millimolar"/>
<variable cmeta:id="id_00062" initial_value="0.00015" name="K_mEGTA" units="millimolar"/>
<variable cmeta:id="id_00060" initial_value="0.05" name="CMDN_tot" units="millimolar"/>
<variable cmeta:id="id_00061" initial_value="15" name="CSQN_tot" units="millimolar"/>
<variable cmeta:id="id_00063" initial_value="10" name="EGTA_tot" units="millimolar"/>
<variable name="beta_i" units="dimensionless"/>
<variable name="beta_SS" units="dimensionless"/>
<variable name="beta_JSR" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<variable name="F" public_interface="in" units="coulomb_per_mole"/>
<variable name="i_Stim" public_interface="in" units="nanoA"/>
<variable cmeta:id="id_00064" name="i_Na" public_interface="in" units="nanoA"/>
<variable cmeta:id="id_00065" name="i_Ca_L" public_interface="in" units="nanoA"/>
<variable cmeta:id="id_00066" name="i_B_Na" public_interface="in" units="nanoA"/>
<variable cmeta:id="id_00067" name="i_NaCa" public_interface="in" units="nanoA"/>
<variable cmeta:id="id_00068" name="i_NaK" public_interface="in" units="nanoA"/>
<variable name="i_f_Na" public_interface="in" units="nanoA"/>
<variable name="i_f_K" public_interface="in" units="nanoA"/>
<variable name="i_B_K" public_interface="in" units="nanoA"/>
<variable name="i_K1" public_interface="in" units="nanoA"/>
<variable name="i_t" public_interface="in" units="nanoA"/>
<variable name="i_ss" public_interface="in" units="nanoA"/>
<variable name="i_Ca_P" public_interface="in" units="nanoA"/>
<variable name="i_B_Ca" public_interface="in" units="nanoA"/>
<variable name="J_up" public_interface="in" units="millimolar_per_second"/>
<variable name="J_rel" public_interface="in" units="millimolar_per_second"/>
<variable name="J_xfer" public_interface="in" units="millimolar_per_second"/>
<variable name="J_trpn" public_interface="in" units="millimolar_per_second"/>
<variable name="J_tr" public_interface="in" units="millimolar_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_tot</ci>
<ci>K_mCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCMDN</ci>
<ci>Ca_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTA_tot</ci>
<ci>K_mEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mEGTA</ci>
<ci>Ca_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_SS</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_tot</ci>
<ci>K_mCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCMDN</ci>
<ci>Ca_ss</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_JSR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQN_tot</ci>
<ci>K_mCSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>K_mCSQN</ci>
<ci>Ca_JSR</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>beta_i</ci>
<apply>
<minus/>
<ci>J_xfer</ci>
<apply>
<plus/>
<ci>J_up</ci>
<ci>J_trpn</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_B_Ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>i_Ca_P</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>i_NaCa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>i_f_Na</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Stim</ci>
<ci>i_ss</ci>
<ci>i_B_K</ci>
<ci>i_t</ci>
<ci>i_K1</ci>
<ci>i_f_K</ci>
<apply>
<times/>
<ci>i_NaK</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_ss</ci>
</apply>
<apply>
<times/>
<ci>beta_SS</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_rel</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_SS</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>J_xfer</ci>
<ci>V_myo</ci>
</apply>
<ci>V_SS</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>i_Ca_L</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_SS</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_JSR</ci>
</apply>
<apply>
<times/>
<ci>beta_JSR</ci>
<apply>
<minus/>
<ci>J_tr</ci>
<ci>J_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_NSR</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_up</ci>
<ci>V_myo</ci>
</apply>
<ci>V_NSR</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>J_tr</ci>
<ci>V_JSR</ci>
</apply>
<ci>V_NSR</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component cmeta:id="id_00071" name="standard_ionic_concentrations">
<variable cmeta:id="id_00069" initial_value="140" name="Na_o" public_interface="out" units="millimolar"/>
<variable cmeta:id="id_00070" initial_value="1.2" name="Ca_o" public_interface="out" units="millimolar"/>
<variable cmeta:id="id_00070" initial_value="5.4" name="K_o" public_interface="out" units="millimolar"/>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
<component_ref component="sodium_current_j_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_11_gate"/>
<component_ref component="L_type_Ca_channel_f_12_gate"/>
<component_ref component="L_type_Ca_channel_Ca_inact_gate"/>
</component_ref>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="inward_rectifier"/>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="background_currents"/>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="sarcolemmal_calcium_pump_current"/>
<component_ref component="Na_Ca_ion_exchanger_current"/>
<component_ref component="SR_Ca_release_channel"/>
<component_ref component="SERCA2a_pump"/>
<component_ref component="intracellular_and_SR_Ca_fluxes"/>
<component_ref component="intracellular_ion_concentrations"/>
<component_ref component="standard_ionic_concentrations"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
<component_ref component="sodium_current_j_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_11_gate"/>
<component_ref component="L_type_Ca_channel_f_12_gate"/>
<component_ref component="L_type_Ca_channel_Ca_inact_gate"/>
</component_ref>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Na_Ca_ion_exchanger_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SR_Ca_release_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="SERCA2a_pump" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="intracellular_and_SR_Ca_fluxes" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Ca_independent_transient_outward_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_t" variable_2="i_t"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="steady_state_outward_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_ss" variable_2="i_ss"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="inward_rectifier"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_f" variable_2="i_f"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_currents"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_B" variable_2="i_B"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sarcolemmal_calcium_pump_current"/>
<map_variables variable_1="i_Ca_P" variable_2="i_Ca_P"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_ion_exchanger_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_Stim" variable_2="i_Stim"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="background_currents"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="background_currents" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
<map_variables variable_1="Ca_ss" variable_2="Ca_ss"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_t" variable_2="i_t"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="steady_state_outward_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="inward_rectifier"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="background_currents"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_ss" variable_2="i_ss"/>
</connection>
<connection>
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