Location: Courtemanche, Ramirez, and Nattel model under atrial fibrillation @ 803542b29e55 / Andy_CRN_AF.cellml
- Author:
- Andy Lo <alo006@aucklanduni.ac.nz>
- Date:
- 2018-09-07 18:03:14+12:00
- Desc:
- Adapted CRN model under AF conditions for provisional year objective.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/525/rawfile/803542b29e55d7a67161b86461cc4b2eba4d5581/Andy_CRN_AF.cellml
<?xml version='1.0'?>
<!--
This CellML file was generated on 29/10/2007 at 15:10:29 using:
COR (0.9.31.801)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
<model cmeta:id="courtemanche_1998" name="courtemanche_1998" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="millisecond">
<unit prefix="milli" units="second"/>
</units>
<units name="per_millisecond">
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_millivolt">
<unit exponent="-1" units="millivolt"/>
</units>
<units name="per_millivolt_millisecond">
<unit exponent="-1" units="millivolt"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millimolar">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="millimolar_per_millisecond">
<unit units="millimolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millisecond_per_millimolar">
<unit units="millisecond"/>
<unit exponent="-1" units="millimolar"/>
</units>
<units name="picoA">
<unit prefix="pico" units="ampere"/>
</units>
<units name="picoA_per_picoF">
<unit prefix="pico" units="ampere"/>
<unit exponent="-1" prefix="pico" units="farad"/>
</units>
<units name="nanoS_per_picoF">
<unit prefix="nano" units="siemens"/>
<unit exponent="-1" prefix="pico" units="farad"/>
</units>
<units name="picoF">
<unit prefix="pico" units="farad"/>
</units>
<units name="micrometre_3">
<unit exponent="3" prefix="micro" units="metre"/>
</units>
<units name="per_micrometre_3">
<unit exponent="-3" prefix="micro" units="metre"/>
</units>
<units name="mm2">
<unit exponent="2" prefix="milli" units="metre"/>
</units>
<units name="joule_per_mole_kelvin">
<unit units="joule"/>
<unit exponent="-1" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="coulomb_per_millimole">
<unit units="coulomb"/>
<unit exponent="-1" prefix="milli" units="mole"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="millisecond"/>
</component>
<component name="membrane">
<variable cmeta:id="membrane_V" initial_value="-81.18" name="V" public_interface="out" units="millivolt"/>
<variable initial_value="8.3143" name="R" public_interface="out" units="joule_per_mole_kelvin"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96.4867" name="F" public_interface="out" units="coulomb_per_millimole"/>
<variable initial_value="120" name="Cm" public_interface="out" units="picoF"/>
<variable name="i_st" units="picoA"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="i_Na" public_interface="in" units="picoA"/>
<variable name="i_K1" public_interface="in" units="picoA"/>
<variable name="i_to" public_interface="in" units="picoA"/>
<variable name="i_Kur" public_interface="in" units="picoA"/>
<variable name="i_Kr" public_interface="in" units="picoA"/>
<variable name="i_Ks" public_interface="in" units="picoA"/>
<variable name="i_Ca_L" public_interface="in" units="picoA"/>
<variable name="i_CaP" public_interface="in" units="picoA"/>
<variable name="i_NaK" public_interface="in" units="picoA"/>
<variable name="i_NaCa" public_interface="in" units="picoA"/>
<variable name="i_B_Na" public_interface="in" units="picoA"/>
<variable name="i_B_Ca" public_interface="in" units="picoA"/>
<variable initial_value="50" name="stim_start" units="millisecond"/>
<variable initial_value="50000" name="stim_end" units="millisecond"/>
<variable initial_value="1000" name="stim_period" units="millisecond"/>
<variable initial_value="2" name="stim_duration" units="millisecond"/>
<variable initial_value="-2000" name="stim_amplitude" units="picoA"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_st</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
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<and/>
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<geq/>
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<ci>stim_start</ci>
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<leq/>
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<ci>stim_end</ci>
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<leq/>
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<minus/>
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<minus/>
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</apply>
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<times/>
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<floor/>
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<divide/>
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<ci>stim_period</ci>
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<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
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</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
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<ci>V</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_K1</ci>
<ci>i_to</ci>
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<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_B_Na</ci>
<ci>i_B_Ca</ci>
<ci>i_NaK</ci>
<ci>i_CaP</ci>
<ci>i_NaCa</ci>
<ci>i_Ca_L</ci>
<ci>i_st</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current">
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<variable name="E_Na" public_interface="out" units="millivolt"/>
<variable initial_value="7.8" name="g_Na" units="nanoS_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Na_i" public_interface="in" units="millimolar"/>
<variable name="Na_o" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="m" private_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" units="dimensionless"/>
<variable name="j" private_interface="in" units="dimensionless"/>
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<apply>
<times/>
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<ci>g_Na</ci>
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<power/>
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</apply>
<ci>h</ci>
<ci>j</ci>
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<minus/>
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<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
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<times/>
<apply>
<divide/>
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<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
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<ln/>
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<divide/>
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<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_m_gate">
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<variable name="alpha_m" units="per_millisecond"/>
<variable name="beta_m" units="per_millisecond"/>
<variable name="m_inf" units="dimensionless"/>
<variable name="tau_m" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
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<apply>
<eq/>
<ci>alpha_m</ci>
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<piece>
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<eq/>
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<apply>
<minus/>
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</apply>
</apply>
</piece>
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<divide/>
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<times/>
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<plus/>
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</apply>
</apply>
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<minus/>
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<exp/>
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<times/>
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<minus/>
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<apply>
<plus/>
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</apply>
</apply>
</apply>
</apply>
</apply>
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<eq/>
<ci>beta_m</ci>
<apply>
<times/>
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<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
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</apply>
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<divide/>
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</apply>
<apply>
<eq/>
<apply>
<diff/>
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</bvar>
<ci>m</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>m_inf</ci>
<ci>m</ci>
</apply>
<ci>tau_m</ci>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_h_gate">
<variable initial_value="9.649e-1" name="h" public_interface="out" units="dimensionless"/>
<variable name="alpha_h" units="per_millisecond"/>
<variable name="beta_h" units="per_millisecond"/>
<variable name="h_inf" units="dimensionless"/>
<variable name="tau_h" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<piecewise>
<piece>
<apply>
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<exp/>
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<divide/>
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<cn cellml:units="millivolt">80</cn>
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<apply>
<minus/>
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</apply>
</apply>
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</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
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<eq/>
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<piecewise>
<piece>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millisecond">3.56</cn>
<apply>
<exp/>
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<times/>
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<ci>V</ci>
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<apply>
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<apply>
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<apply>
<times/>
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<minus/>
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<exp/>
<apply>
<divide/>
<apply>
<plus/>
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<minus/>
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<divide/>
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<divide/>
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<eq/>
<apply>
<diff/>
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<divide/>
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<minus/>
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<variable name="beta_j" units="per_millisecond"/>
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<variable name="tau_j" units="millisecond"/>
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<apply>
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<minus/>
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<minus/>
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<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
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<times/>
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<apply>
<plus/>
<ci>V</ci>
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</apply>
</apply>
</apply>
</apply>
</otherwise>
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<apply>
<eq/>
<ci>j_inf</ci>
<apply>
<divide/>
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<apply>
<plus/>
<ci>alpha_j</ci>
<ci>beta_j</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_j</ci>
<apply>
<divide/>
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<apply>
<plus/>
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<ci>beta_j</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
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<apply>
<divide/>
<apply>
<minus/>
<ci>j_inf</ci>
<ci>j</ci>
</apply>
<ci>tau_j</ci>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable name="i_K1" public_interface="out" units="picoA"/>
<variable name="E_K" public_interface="out" units="millivolt"/>
<variable initial_value="0.18" name="g_K1" units="nanoS_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="K_o" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="K_i" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_K1</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
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<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.07</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_K_current">
<variable name="i_to" public_interface="out" units="picoA"/>
<variable initial_value="3" name="K_Q10" private_interface="out" public_interface="out" units="dimensionless"/>
<variable initial_value="0.05782" name="g_to" units="nanoS_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="oa" private_interface="in" units="dimensionless"/>
<variable name="oi" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_to</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_to</ci>
<apply>
<power/>
<ci>oa</ci>
<cn cellml:units="dimensionless">3</cn>
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<ci>oi</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
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</apply>
</apply>
</math>
</component>
<component name="transient_outward_K_current_oa_gate">
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<variable name="alpha_oa" units="per_millisecond"/>
<variable name="beta_oa" units="per_millisecond"/>
<variable name="tau_oa" units="millisecond"/>
<variable name="oa_infinity" units="dimensionless"/>
<variable name="K_Q10" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_oa</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.65</cn>
<apply>
<power/>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">8.5</cn>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">40</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">59</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_oa</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.65</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">2.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">72</cn>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_oa</ci>
<apply>
<divide/>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_oa</ci>
<ci>beta_oa</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>K_Q10</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>oa_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">10.47</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">17.54</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>oa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>oa_infinity</ci>
<ci>oa</ci>
</apply>
<ci>tau_oa</ci>
</apply>
</apply>
</math>
</component>
<component name="transient_outward_K_current_oi_gate">
<variable initial_value="9.992e-1" name="oi" public_interface="out" units="dimensionless"/>
<variable name="alpha_oi" units="per_millisecond"/>
<variable name="beta_oi" units="per_millisecond"/>
<variable name="tau_oi" units="millisecond"/>
<variable name="oi_infinity" units="dimensionless"/>
<variable name="K_Q10" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_oi</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="millisecond">18.53</cn>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">103.7</cn>
</apply>
<cn cellml:units="millivolt">10.95</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_oi</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="millisecond">35.56</cn>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">8.74</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">7.44</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_oi</ci>
<apply>
<divide/>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_oi</ci>
<ci>beta_oi</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>K_Q10</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>oi_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">33.1</cn>
</apply>
<cn cellml:units="millivolt">5.3</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>oi</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>oi_infinity</ci>
<ci>oi</ci>
</apply>
<ci>tau_oi</ci>
</apply>
</apply>
</math>
</component>
<component name="ultrarapid_delayed_rectifier_K_current">
<variable name="i_Kur" public_interface="out" units="picoA"/>
<variable name="g_Kur" units="nanoS_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="K_Q10" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="ua" private_interface="in" units="dimensionless"/>
<variable name="ui" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_Kur</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<plus/>
<cn cellml:units="nanoS_per_picoF">0.005</cn>
<apply>
<divide/>
<cn cellml:units="nanoS_per_picoF">0.05</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">15</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Kur</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_Kur</ci>
<apply>
<power/>
<ci>ua</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>ui</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ultrarapid_delayed_rectifier_K_current_ua_gate">
<variable initial_value="4.966e-3" name="ua" public_interface="out" units="dimensionless"/>
<variable name="alpha_ua" units="per_millisecond"/>
<variable name="beta_ua" units="per_millisecond"/>
<variable name="tau_ua" units="millisecond"/>
<variable name="ua_infinity" units="dimensionless"/>
<variable name="K_Q10" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_ua</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.65</cn>
<apply>
<power/>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">8.5</cn>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">40</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">59</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_ua</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.65</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">2.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">72</cn>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_ua</ci>
<apply>
<divide/>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_ua</ci>
<ci>beta_ua</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>K_Q10</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ua_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20.3</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">9.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ua</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ua_infinity</ci>
<ci>ua</ci>
</apply>
<ci>tau_ua</ci>
</apply>
</apply>
</math>
</component>
<component name="ultrarapid_delayed_rectifier_K_current_ui_gate">
<variable initial_value="9.986e-1" name="ui" public_interface="out" units="dimensionless"/>
<variable name="alpha_ui" units="per_millisecond"/>
<variable name="beta_ui" units="per_millisecond"/>
<variable name="tau_ui" units="millisecond"/>
<variable name="ui_infinity" units="dimensionless"/>
<variable name="K_Q10" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_ui</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="millisecond">21</cn>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">195</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">28</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_ui</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">168</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">16</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_ui</ci>
<apply>
<divide/>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_ui</ci>
<ci>beta_ui</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>K_Q10</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ui_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt">109.45</cn>
</apply>
<cn cellml:units="millivolt">27.48</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ui</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ui_infinity</ci>
<ci>ui</ci>
</apply>
<ci>tau_ui</ci>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_K_current">
<variable name="i_Kr" public_interface="out" units="picoA"/>
<variable initial_value="0.029411765" name="g_Kr" units="nanoS_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="xr" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_Kr</ci>
<ci>xr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">15</cn>
</apply>
<cn cellml:units="millivolt">22.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_K_current_xr_gate">
<variable initial_value="3.296e-5" name="xr" public_interface="out" units="dimensionless"/>
<variable name="alpha_xr" units="per_millisecond"/>
<variable name="beta_xr" units="per_millisecond"/>
<variable name="tau_xr" units="millisecond"/>
<variable name="xr_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_xr</ci>
<piecewise>
<piece>
<cn cellml:units="per_millisecond">0.0015</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.1</cn>
</apply>
</apply>
<cn cellml:units="millivolt" type="e-notation">1<sep/>-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.0003</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.1</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.1</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_xr</ci>
<piecewise>
<piece>
<cn cellml:units="per_millisecond" type="e-notation">3.7836118<sep/>-4</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">3.3328</cn>
</apply>
</apply>
<cn cellml:units="millivolt" type="e-notation">1<sep/>-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.000073898</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">3.3328</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">3.3328</cn>
</apply>
<cn cellml:units="millivolt">5.1237</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_xr</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_xr</ci>
<ci>beta_xr</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>xr_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.1</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xr</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>xr_infinity</ci>
<ci>xr</ci>
</apply>
<ci>tau_xr</ci>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifier_K_current">
<variable cmeta:id="slow_delayed_rectifier_K_current_i_Ks" name="i_Ks" public_interface="out" units="picoA"/>
<variable initial_value="0.25882352" name="g_Ks" units="nanoS_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="xs" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_Ks</ci>
<apply>
<power/>
<ci>xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifier_K_current_xs_gate">
<variable initial_value="1.869e-2" name="xs" public_interface="out" units="dimensionless"/>
<variable name="alpha_xs" units="per_millisecond"/>
<variable name="beta_xs" units="per_millisecond"/>
<variable name="tau_xs" units="millisecond"/>
<variable name="xs_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_xs</ci>
<piecewise>
<piece>
<cn cellml:units="per_millisecond">0.00068</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.9</cn>
</apply>
</apply>
<cn cellml:units="millivolt" type="e-notation">1<sep/>-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.00004</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.9</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.9</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_xs</ci>
<piecewise>
<piece>
<cn cellml:units="per_millisecond">0.000315</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.9</cn>
</apply>
</apply>
<cn cellml:units="millivolt" type="e-notation">1<sep/>-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.000035</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.9</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.9</cn>
</apply>
<cn cellml:units="millivolt">9</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_xs</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<power/>
<apply>
<plus/>
<ci>alpha_xs</ci>
<ci>beta_xs</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>xs_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">19.9</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">12.7</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.5</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>xs</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>xs_infinity</ci>
<ci>xs</ci>
</apply>
<ci>tau_xs</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel">
<variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="picoA"/>
<variable initial_value="0.0556875" name="g_Ca_L" units="nanoS_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Ca_i" private_interface="out" public_interface="in" units="millimolar"/>
<variable name="d" private_interface="in" units="dimensionless"/>
<variable name="f" private_interface="in" units="dimensionless"/>
<variable name="f_Ca" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ca_L</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_Ca_L</ci>
<ci>d</ci>
<ci>f</ci>
<ci>f_Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">65</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_d_gate">
<variable initial_value="1.367e-4" name="d" public_interface="out" units="dimensionless"/>
<variable name="d_infinity" units="dimensionless"/>
<variable name="tau_d" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="millisecond">4.579</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.24</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<cn cellml:units="millivolt" type="e-notation">1<sep/>-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.24</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.035</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.24</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_infinity</ci>
<ci>d</ci>
</apply>
<ci>tau_d</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f_gate">
<variable initial_value="9.996e-1" name="f" public_interface="out" units="dimensionless"/>
<variable name="f_infinity" units="dimensionless"/>
<variable name="tau_f" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_infinity</ci>
<apply>
<divide/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.9</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">28</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f</ci>
<apply>
<times/>
<cn cellml:units="millisecond">9</cn>
<apply>
<power/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0197</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<power/>
<cn cellml:units="per_millivolt">0.0337</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.02</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_infinity</ci>
<ci>f</ci>
</apply>
<ci>tau_f</ci>
</apply>
</apply>
</math>
</component>
<component name="L_type_Ca_channel_f_Ca_gate">
<variable initial_value="7.755e-1" name="f_Ca" public_interface="out" units="dimensionless"/>
<variable name="f_Ca_infinity" units="dimensionless"/>
<variable name="tau_f_Ca" units="millisecond"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_Ca_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.00035</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_Ca</ci>
<cn cellml:units="millisecond">2</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_Ca</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_Ca_infinity</ci>
<ci>f_Ca</ci>
</apply>
<ci>tau_f_Ca</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable cmeta:id="sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="picoA"/>
<variable initial_value="10" name="Km_Na_i" units="millimolar"/>
<variable initial_value="1.5" name="Km_K_o" units="millimolar"/>
<variable initial_value="0.59933874" name="i_NaK_max" units="picoA_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="f_NaK" units="dimensionless"/>
<variable name="sigma" units="dimensionless"/>
<variable name="K_o" public_interface="in" units="millimolar"/>
<variable name="Na_i" public_interface="in" units="millimolar"/>
<variable name="Na_o" public_interface="in" units="millimolar"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Na_o</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>F</ci>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>i_NaK_max</ci>
<ci>f_NaK</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Na_i</ci>
<ci>Na_i</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<ci>K_o</ci>
</apply>
<apply>
<plus/>
<ci>K_o</ci>
<ci>Km_K_o</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="background_currents">
<variable name="i_B_Na" public_interface="out" units="picoA"/>
<variable name="i_B_Ca" public_interface="out" units="picoA"/>
<variable name="i_B_K" public_interface="out" units="picoA"/>
<variable initial_value="0.0006744375" name="g_B_Na" units="nanoS_per_picoF"/>
<variable initial_value="0.001131" name="g_B_Ca" units="nanoS_per_picoF"/>
<variable initial_value="0" name="g_B_K" units="nanoS_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="E_Ca" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="E_Na" public_interface="in" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="Ca_o" public_interface="in" units="millimolar"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="T" public_interface="in" units="kelvin"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_B_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_Ca</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_B_Ca</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_K</ci>
<apply>
<times/>
<ci>Cm</ci>
<ci>g_B_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_exchanger_current">
<variable cmeta:id="Na_Ca_exchanger_current_i_NaCa" name="i_NaCa" public_interface="out" units="picoA"/>
<variable initial_value="1600" name="I_NaCa_max" units="picoA_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable initial_value="87.5" name="K_mNa" units="millimolar"/>
<variable initial_value="1.38" name="K_mCa" units="millimolar"/>
<variable initial_value="0.1" name="K_sat" units="dimensionless"/>
<variable initial_value="0.35" name="gamma" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Na_i" public_interface="in" units="millimolar"/>
<variable name="Na_o" public_interface="in" units="millimolar"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="Ca_o" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.6</cn>
<ci>Cm</ci>
<ci>I_NaCa_max</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mNa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>K_mCa</ci>
<ci>Ca_o</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>K_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sarcolemmal_calcium_pump_current">
<variable cmeta:id="sarcolemmal_calcium_pump_current_i_CaP" name="i_CaP" public_interface="out" units="picoA"/>
<variable initial_value="0.275" name="i_CaP_max" units="picoA_per_picoF"/>
<variable name="Cm" public_interface="in" units="picoF"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaP</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cm</ci>
<ci>i_CaP_max</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="millimolar">0.0005</cn>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_release_current_from_JSR">
<variable name="i_rel" public_interface="out" units="millimolar_per_millisecond"/>
<variable name="Fn" private_interface="out" units="dimensionless"/>
<variable initial_value="30" name="K_rel" units="per_millisecond"/>
<variable name="V_rel" public_interface="in" units="micrometre_3"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="Ca_rel" public_interface="in" units="millimolar"/>
<variable name="i_Ca_L" public_interface="in" units="picoA"/>
<variable name="i_NaCa" public_interface="in" units="picoA"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="u" private_interface="in" units="dimensionless"/>
<variable name="v" private_interface="in" units="dimensionless"/>
<variable name="w" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Fn</ci>
<apply>
<times/>
<cn cellml:units="millisecond_per_millimolar" type="e-notation">1<sep/>3</cn>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="per_micrometre_3" type="e-notation">1<sep/>-15</cn>
<ci>V_rel</ci>
<ci>i_rel</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="per_micrometre_3" type="e-notation">1<sep/>-15</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>i_Ca_L</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_rel</ci>
<apply>
<times/>
<ci>K_rel</ci>
<apply>
<power/>
<ci>u</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>v</ci>
<ci>w</ci>
<apply>
<minus/>
<ci>Ca_rel</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_release_current_from_JSR_u_gate">
<variable initial_value="2.35e-112" name="u" public_interface="out" units="dimensionless"/>
<variable name="tau_u" units="millisecond"/>
<variable name="u_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Fn" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_u</ci>
<cn cellml:units="millisecond">8</cn>
</apply>
<apply>
<eq/>
<ci>u_infinity</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Fn</ci>
<cn cellml:units="dimensionless" type="e-notation">3.4175<sep/>-13</cn>
</apply>
</apply>
<cn cellml:units="dimensionless" type="e-notation">13.67<sep/>-16</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>u</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>u_infinity</ci>
<ci>u</ci>
</apply>
<ci>tau_u</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_release_current_from_JSR_v_gate">
<variable initial_value="1" name="v" public_interface="out" units="dimensionless"/>
<variable name="tau_v" units="millisecond"/>
<variable name="v_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Fn" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_v</ci>
<apply>
<plus/>
<cn cellml:units="millisecond">1.91</cn>
<apply>
<times/>
<cn cellml:units="millisecond">2.09</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Fn</ci>
<cn cellml:units="dimensionless" type="e-notation">3.4175<sep/>-13</cn>
</apply>
</apply>
<cn cellml:units="dimensionless" type="e-notation">13.67<sep/>-16</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_infinity</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Fn</ci>
<cn cellml:units="dimensionless" type="e-notation">6.835<sep/>-14</cn>
</apply>
</apply>
<cn cellml:units="dimensionless" type="e-notation">13.67<sep/>-16</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>v</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>v_infinity</ci>
<ci>v</ci>
</apply>
<ci>tau_v</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_release_current_from_JSR_w_gate">
<variable initial_value="0.9992" name="w" public_interface="out" units="dimensionless"/>
<variable name="tau_w" units="millisecond"/>
<variable name="w_infinity" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>tau_w</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">6</cn>
<cn cellml:units="dimensionless">0.2</cn>
</apply>
<cn cellml:units="dimensionless">1.3</cn>
</apply>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.9</cn>
</apply>
</apply>
<cn cellml:units="millivolt" type="e-notation">1<sep/>-10</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">6</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.9</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.3</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.9</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="per_millivolt">1</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.9</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>w_infinity</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>w</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>w_infinity</ci>
<ci>w</ci>
</apply>
<ci>tau_w</ci>
</apply>
</apply>
</math>
</component>
<component name="transfer_current_from_NSR_to_JSR">
<variable name="i_tr" public_interface="out" units="millimolar_per_millisecond"/>
<variable initial_value="180" name="tau_tr" units="millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Ca_rel" public_interface="in" units="millimolar"/>
<variable name="Ca_up" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Ca_up</ci>
<ci>Ca_rel</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_uptake_current_by_the_NSR">
<variable initial_value="0.005" name="I_up_max" public_interface="out" units="millimolar_per_millisecond"/>
<variable name="i_up" public_interface="out" units="millimolar_per_millisecond"/>
<variable initial_value="0.00092" name="K_up" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_up</ci>
<apply>
<divide/>
<ci>I_up_max</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_up</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Ca_leak_current_by_the_NSR">
<variable name="i_up_leak" public_interface="out" units="millimolar_per_millisecond"/>
<variable initial_value="15" name="Ca_up_max" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Ca_up" public_interface="in" units="millimolar"/>
<variable name="I_up_max" public_interface="in" units="millimolar_per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_up_leak</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.5</cn>
<ci>I_up_max</ci>
<ci>Ca_up</ci>
</apply>
<ci>Ca_up_max</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_buffers">
<variable initial_value="0.05" name="CMDN_max" public_interface="out" units="millimolar"/>
<variable initial_value="0.07" name="TRPN_max" public_interface="out" units="millimolar"/>
<variable initial_value="10" name="CSQN_max" public_interface="out" units="millimolar"/>
<variable initial_value="0.00238" name="Km_CMDN" public_interface="out" units="millimolar"/>
<variable initial_value="0.0005" name="Km_TRPN" public_interface="out" units="millimolar"/>
<variable initial_value="0.8" name="Km_CSQN" public_interface="out" units="millimolar"/>
<variable name="Ca_CMDN" units="millimolar"/>
<variable name="Ca_TRPN" units="millimolar"/>
<variable name="Ca_CSQN" units="millimolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Ca_i" public_interface="in" units="millimolar"/>
<variable name="Ca_rel" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Ca_CMDN</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_max</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>Km_CMDN</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ca_TRPN</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>TRPN_max</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>Km_TRPN</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ca_CSQN</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQN_max</ci>
<ci>Ca_rel</ci>
</apply>
<apply>
<plus/>
<ci>Ca_rel</ci>
<ci>Km_CSQN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_ion_concentrations">
<variable initial_value="1.117e+01" name="Na_i" public_interface="out" units="millimolar"/>
<variable initial_value="1.013e-4" name="Ca_i" public_interface="out" units="millimolar"/>
<variable initial_value="1.39e+02" name="K_i" public_interface="out" units="millimolar"/>
<variable initial_value="1.488" name="Ca_rel" public_interface="out" units="millimolar"/>
<variable initial_value="1.488" name="Ca_up" public_interface="out" units="millimolar"/>
<variable initial_value="20100" name="V_cell" units="micrometre_3"/>
<variable name="V_i" units="micrometre_3"/>
<variable name="V_rel" public_interface="out" units="micrometre_3"/>
<variable name="V_up" units="micrometre_3"/>
<variable name="B1" units="millimolar_per_millisecond"/>
<variable name="B2" units="dimensionless"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="i_NaK" public_interface="in" units="picoA"/>
<variable name="i_NaCa" public_interface="in" units="picoA"/>
<variable name="i_B_Na" public_interface="in" units="picoA"/>
<variable name="i_Na" public_interface="in" units="picoA"/>
<variable name="i_K1" public_interface="in" units="picoA"/>
<variable name="i_to" public_interface="in" units="picoA"/>
<variable name="i_Kur" public_interface="in" units="picoA"/>
<variable name="i_Kr" public_interface="in" units="picoA"/>
<variable name="i_Ks" public_interface="in" units="picoA"/>
<variable name="i_CaP" public_interface="in" units="picoA"/>
<variable name="i_Ca_L" public_interface="in" units="picoA"/>
<variable name="i_B_Ca" public_interface="in" units="picoA"/>
<variable name="i_B_K" public_interface="in" units="picoA"/>
<variable name="i_up" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="i_up_leak" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="i_tr" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="i_rel" public_interface="in" units="millimolar_per_millisecond"/>
<variable name="Km_CMDN" public_interface="in" units="millimolar"/>
<variable name="Km_CSQN" public_interface="in" units="millimolar"/>
<variable name="Km_TRPN" public_interface="in" units="millimolar"/>
<variable name="CMDN_max" public_interface="in" units="millimolar"/>
<variable name="CSQN_max" public_interface="in" units="millimolar"/>
<variable name="TRPN_max" public_interface="in" units="millimolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_i</ci>
<apply>
<times/>
<ci>V_cell</ci>
<cn cellml:units="dimensionless">0.68</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>V_rel</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0048</cn>
<ci>V_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_up</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0552</cn>
<ci>V_cell</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>i_NaK</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa</ci>
</apply>
<ci>i_B_Na</ci>
<ci>i_Na</ci>
</apply>
</apply>
<apply>
<times/>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaK</ci>
</apply>
<apply>
<plus/>
<ci>i_K1</ci>
<ci>i_to</ci>
<ci>i_Kur</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_B_K</ci>
</apply>
</apply>
<apply>
<times/>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<divide/>
<ci>B1</ci>
<ci>B2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>B1</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
<apply>
<plus/>
<ci>i_CaP</ci>
<ci>i_Ca_L</ci>
<ci>i_B_Ca</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>V_up</ci>
<apply>
<minus/>
<ci>i_up_leak</ci>
<ci>i_up</ci>
</apply>
</apply>
<apply>
<times/>
<ci>i_rel</ci>
<ci>V_rel</ci>
</apply>
</apply>
<ci>V_i</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>B2</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>TRPN_max</ci>
<ci>Km_TRPN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>Km_TRPN</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_max</ci>
<ci>Km_CMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_i</ci>
<ci>Km_CMDN</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_up</ci>
</apply>
<apply>
<minus/>
<ci>i_up</ci>
<apply>
<plus/>
<ci>i_up_leak</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_tr</ci>
<ci>V_rel</ci>
</apply>
<ci>V_up</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_rel</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>i_tr</ci>
<ci>i_rel</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQN_max</ci>
<ci>Km_CSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_rel</ci>
<ci>Km_CSQN</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="standard_ionic_concentrations">
<variable initial_value="140" name="Na_o" public_interface="out" units="millimolar"/>
<variable initial_value="1.8" name="Ca_o" public_interface="out" units="millimolar"/>
<variable initial_value="5.4" name="K_o" public_interface="out" units="millimolar"/>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="time_independent_potassium_current"/>
<component_ref component="transient_outward_K_current">
<component_ref component="transient_outward_K_current_oa_gate"/>
<component_ref component="transient_outward_K_current_oi_gate"/>
</component_ref>
<component_ref component="ultrarapid_delayed_rectifier_K_current">
<component_ref component="ultrarapid_delayed_rectifier_K_current_ua_gate"/>
<component_ref component="ultrarapid_delayed_rectifier_K_current_ui_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifier_K_current">
<component_ref component="rapid_delayed_rectifier_K_current_xr_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifier_K_current">
<component_ref component="slow_delayed_rectifier_K_current_xs_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f_Ca_gate"/>
</component_ref>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="background_currents"/>
<component_ref component="Na_Ca_exchanger_current"/>
<component_ref component="sarcolemmal_calcium_pump_current"/>
<component_ref component="Ca_release_current_from_JSR">
<component_ref component="Ca_release_current_from_JSR_u_gate"/>
<component_ref component="Ca_release_current_from_JSR_v_gate"/>
<component_ref component="Ca_release_current_from_JSR_w_gate"/>
</component_ref>
<component_ref component="transfer_current_from_NSR_to_JSR"/>
<component_ref component="Ca_uptake_current_by_the_NSR"/>
<component_ref component="Ca_leak_current_by_the_NSR"/>
<component_ref component="Ca_buffers"/>
<component_ref component="intracellular_ion_concentrations"/>
<component_ref component="standard_ionic_concentrations"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="transient_outward_K_current">
<component_ref component="transient_outward_K_current_oa_gate"/>
<component_ref component="transient_outward_K_current_oi_gate"/>
</component_ref>
<component_ref component="ultrarapid_delayed_rectifier_K_current">
<component_ref component="ultrarapid_delayed_rectifier_K_current_ua_gate"/>
<component_ref component="ultrarapid_delayed_rectifier_K_current_ui_gate"/>
</component_ref>
<component_ref component="rapid_delayed_rectifier_K_current">
<component_ref component="rapid_delayed_rectifier_K_current_xr_gate"/>
</component_ref>
<component_ref component="slow_delayed_rectifier_K_current">
<component_ref component="slow_delayed_rectifier_K_current_xs_gate"/>
</component_ref>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_d_gate"/>
<component_ref component="L_type_Ca_channel_f_gate"/>
<component_ref component="L_type_Ca_channel_f_Ca_gate"/>
</component_ref>
<component_ref component="Ca_release_current_from_JSR">
<component_ref component="Ca_release_current_from_JSR_u_gate"/>
<component_ref component="Ca_release_current_from_JSR_v_gate"/>
<component_ref component="Ca_release_current_from_JSR_w_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="transient_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_delayed_rectifier_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_release_current_from_JSR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="transfer_current_from_NSR_to_JSR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_uptake_current_by_the_NSR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_leak_current_by_the_NSR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_buffers" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="transient_outward_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ultrarapid_delayed_rectifier_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="rapid_delayed_rectifier_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_delayed_rectifier_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_currents"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_B_Ca" variable_2="i_B_Ca"/>
<map_variables variable_1="i_B_Na" variable_2="i_B_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sarcolemmal_calcium_pump_current"/>
<map_variables variable_1="i_CaP" variable_2="i_CaP"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="Ca_release_current_from_JSR" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="background_currents"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="transient_outward_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="background_currents"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="ultrarapid_delayed_rectifier_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="rapid_delayed_rectifier_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="slow_delayed_rectifier_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="transient_outward_K_current"/>
<map_variables variable_1="K_Q10" variable_2="K_Q10"/>
</connection>
<connection>
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="slow_delayed_rectifier_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="transient_outward_K_current"/>
<map_variables variable_1="i_to" variable_2="i_to"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="Ca_release_current_from_JSR"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="background_currents" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="i_B_Ca" variable_2="i_B_Ca"/>
<map_variables variable_1="i_B_Na" variable_2="i_B_Na"/>
<map_variables variable_1="i_B_K" variable_2="i_B_K"/>
</connection>
<connection>
<map_components component_1="background_currents" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger_current" component_2="standard_ionic_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger_current" component_2="Ca_release_current_from_JSR"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_CaP" variable_2="i_CaP"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="Ca_release_current_from_JSR"/>
<map_variables variable_1="i_rel" variable_2="i_rel"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_rel" variable_2="Ca_rel"/>
<map_variables variable_1="V_rel" variable_2="V_rel"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="transfer_current_from_NSR_to_JSR"/>
<map_variables variable_1="i_tr" variable_2="i_tr"/>
<map_variables variable_1="Ca_up" variable_2="Ca_up"/>
<map_variables variable_1="Ca_rel" variable_2="Ca_rel"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="Ca_uptake_current_by_the_NSR"/>
<map_variables variable_1="i_up" variable_2="i_up"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="Ca_leak_current_by_the_NSR" component_2="Ca_uptake_current_by_the_NSR"/>
<map_variables variable_1="I_up_max" variable_2="I_up_max"/>
</connection>
<connection>
<map_components component_1="Ca_leak_current_by_the_NSR" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_up_leak" variable_2="i_up_leak"/>
<map_variables variable_1="Ca_up" variable_2="Ca_up"/>
</connection>
<connection>
<map_components component_1="Ca_buffers" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="CMDN_max" variable_2="CMDN_max"/>
<map_variables variable_1="CSQN_max" variable_2="CSQN_max"/>
<map_variables variable_1="TRPN_max" variable_2="TRPN_max"/>
<map_variables variable_1="Km_CMDN" variable_2="Km_CMDN"/>
<map_variables variable_1="Km_CSQN" variable_2="Km_CSQN"/>
<map_variables variable_1="Km_TRPN" variable_2="Km_TRPN"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_rel" variable_2="Ca_rel"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_gate"/>
<map_variables variable_1="f" variable_2="f"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_Ca_gate"/>
<map_variables variable_1="f_Ca" variable_2="f_Ca"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="transient_outward_K_current" component_2="transient_outward_K_current_oa_gate"/>
<map_variables variable_1="oa" variable_2="oa"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="K_Q10" variable_2="K_Q10"/>
</connection>
<connection>
<map_components component_1="transient_outward_K_current" component_2="transient_outward_K_current_oi_gate"/>
<map_variables variable_1="oi" variable_2="oi"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="K_Q10" variable_2="K_Q10"/>
</connection>
<connection>
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="ultrarapid_delayed_rectifier_K_current_ua_gate"/>
<map_variables variable_1="ua" variable_2="ua"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="K_Q10" variable_2="K_Q10"/>
</connection>
<connection>
<map_components component_1="ultrarapid_delayed_rectifier_K_current" component_2="ultrarapid_delayed_rectifier_K_current_ui_gate"/>
<map_variables variable_1="ui" variable_2="ui"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="K_Q10" variable_2="K_Q10"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_K_current" component_2="rapid_delayed_rectifier_K_current_xr_gate"/>
<map_variables variable_1="xr" variable_2="xr"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="slow_delayed_rectifier_K_current" component_2="slow_delayed_rectifier_K_current_xs_gate"/>
<map_variables variable_1="xs" variable_2="xs"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ca_release_current_from_JSR" component_2="Ca_release_current_from_JSR_u_gate"/>
<map_variables variable_1="u" variable_2="u"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Fn" variable_2="Fn"/>
</connection>
<connection>
<map_components component_1="Ca_release_current_from_JSR" component_2="Ca_release_current_from_JSR_v_gate"/>
<map_variables variable_1="v" variable_2="v"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Fn" variable_2="Fn"/>
</connection>
<connection>
<map_components component_1="Ca_release_current_from_JSR" component_2="Ca_release_current_from_JSR_w_gate"/>
<map_variables variable_1="w" variable_2="w"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
</model>