- Author:
- Michael Cooling <mcoo001@UoA.auckland.ac.nz>
- Date:
- 2016-04-11 12:30:41+12:00
- Desc:
- Adding .zip of complete model
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/2c4/rawfile/ad404d66f734c5e175dca6c4601b7a2f00d8a1a3/Calcium_Handling.cellml
<?xml version="1.0" encoding="utf-8"?>
<model xmlns:xlink="http://www.w3.org/1999/xlink" name="Calcium_Handling" cmeta:id="Calcium_Handling" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Principled_Base/Units_Cellular_Systems.cellml">
<units name="per_s" units_ref="per_s"/>
<units name="per_m" units_ref="per_m"/>
<units name="per_m2" units_ref="per_m2"/>
<units name="N_per_m2" units_ref="N_per_m2"/>
<units name="m2_per_N" units_ref="m2_per_N"/>
<units name="N_per_m" units_ref="N_per_m"/>
<units name="N_m_per_K" units_ref="N_m_per_K"/>
<units name="uM" units_ref="uM"/>
<units name="uM_per_s" units_ref="uM_per_s"/>
<units name="per_uM_per_s" units_ref="per_uM_per_s"/>
</import>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="Calcium_Handling">
<component_ref component="Ca_st" />
<component_ref component="Ca_st_delta" />
<component_ref component="Ca_if" />
<component_ref component="Ca_if_delta" />
<component_ref component="CaStore_Release" />
<component_ref component="CaStore_Resequestration" />
<component_ref component="Ca_Extrusions">
<component_ref component="Ca_Extrusion_Basal" />
<component_ref component="Ca_Extrusion_Pump" />
<component_ref component="Ca_Extrusion_Exch" />
</component_ref>
<component_ref component="Ca_Intrusions" >
<component_ref component="Ca_Intrusion_StressSensitiveChannels" />
<component_ref component="Ca_Intrusion_CCE" />
</component_ref>
</component_ref>
</group>
<component name="Calcium_Handling">
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Ca_st_init" units="uM" public_interface="in" private_interface="out"/>
<variable name="V_ce" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="J_Ca_st_External" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="J_Ca_if_External" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="Ca_if_init" units="uM" public_interface="in" private_interface="out"/>
<variable name="qrel_k2" units="per_s" public_interface="in" private_interface="out"/>
<variable name="IP3" units="uM" public_interface="in" private_interface="out"/>
<variable name="qrel_k1" units="uM" public_interface="in" private_interface="out"/>
<variable name="qres_k1" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qres_k2" units="uM" public_interface="in" private_interface="out"/>
<variable name="qres_k3" units="per_uM_per_s" public_interface="in" private_interface="out"/>
<variable name="Ca_if_rest" units="uM" public_interface="in" private_interface="out"/>
<variable name="qout_basal_vmax" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qout_basal_Km" units="uM" public_interface="in" private_interface="out"/>
<variable name="qout_basal_n" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="qout_pump_vmax" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qout_pump_Km" units="uM" public_interface="in" private_interface="out"/>
<variable name="qout_pump_n" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="qout_exch_vmax" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qout_exch_Km" units="uM" public_interface="in" private_interface="out"/>
<variable name="qout_exch_n" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="Ca_ex" units="uM" public_interface="in" private_interface="out"/>
<variable name="l" units="meter" public_interface="in" private_interface="out"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="tau" units="N_per_m2" public_interface="in" private_interface="out"/>
<variable name="Ca_st_rest" units="uM" public_interface="in" private_interface="out"/>
<variable name="qin_kcce" units="per_uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qin_max" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qin_alpha" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="qinw_f" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="epsilon" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="k" units="N_m_per_K" public_interface="in" private_interface="out"/>
<variable name="cac" units="per_m2" public_interface="in" private_interface="out"/>
<variable name="qinw_delta" units="N_per_m" public_interface="in" private_interface="out"/>
<variable name="Ca_st" units="uM" private_interface="in" public_interface="out"/>
<variable name="J_Ca_st" units="uM_per_s" private_interface="in" public_interface="out" />
<variable name="Ca_if" units="uM" private_interface="in" public_interface="out" />
<variable name="J_Ca_if" units="uM_per_s" private_interface="in" public_interface="out" />
</component>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Principled_Base/Template_Species_uM.cellml">
<component name="Ca_st" component_ref="Template_Species_uM"/>
</import>
<connection>
<map_components component_1="Ca_st" component_2="Calcium_Handling"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="concentrationInitialValue" variable_2="Ca_st_init"/>
<map_variables variable_1="concentration" variable_2="Ca_st"/>
</connection>
<connection>
<map_components component_1="Ca_st" component_2="Ca_st_delta"/>
<map_variables variable_1="JGain" variable_2="JNet"/>
</connection>
<component name="Ca_st_delta">
<variable name="JPlusCaStore_Resequestration" units="uM_per_s" public_interface="in" />
<variable name="JMinusCaStore_Release" units="uM_per_s" public_interface="in" />
<variable name="JExternal" units="uM_per_s" public_interface="in" />
<variable name="V_ce" units="dimensionless" public_interface="in" />
<variable name="JNet" units="uM_per_s" public_interface="out" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>JNet</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>V_ce</ci>
<apply>
<minus/>
<ci>JPlusCaStore_Resequestration</ci>
<ci>JMinusCaStore_Release</ci>
</apply>
</apply>
<ci>JExternal</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="Ca_st_delta" component_2="Calcium_Handling"/>
<map_variables variable_1="V_ce" variable_2="V_ce"/>
<map_variables variable_1="JNet" variable_2="J_Ca_st"/>
<map_variables variable_1="JExternal" variable_2="J_Ca_st_External"/>
</connection>
<connection>
<map_components component_1="Ca_st_delta" component_2="CaStore_Release"/>
<map_variables variable_1="JMinusCaStore_Release" variable_2="J_rel"/>
</connection>
<connection>
<map_components component_1="Ca_st_delta" component_2="CaStore_Resequestration"/>
<map_variables variable_1="JPlusCaStore_Resequestration" variable_2="J_res"/>
</connection>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Principled_Base/Template_Species_uM.cellml">
<component name="Ca_if" component_ref="Template_Species_uM"/>
</import>
<connection>
<map_components component_1="Ca_if" component_2="Calcium_Handling"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="concentrationInitialValue" variable_2="Ca_if_init"/>
<map_variables variable_1="concentration" variable_2="Ca_if"/>
</connection>
<connection>
<map_components component_1="Ca_if" component_2="Ca_if_delta"/>
<map_variables variable_1="JGain" variable_2="JNet"/>
</connection>
<component name="Ca_if_delta">
<variable name="JPlusCaStore_Release" units="uM_per_s" public_interface="in" />
<variable name="JMinusCaStore_Resequestration" units="uM_per_s" public_interface="in" />
<variable name="JExternal" units="uM_per_s" public_interface="in" />
<variable name="JMinusCa_if_Out" units="uM_per_s" public_interface="in" />
<variable name="JPlusCa_if_In" units="uM_per_s" public_interface="in" />
<variable name="JNet" units="uM_per_s" public_interface="out" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>JNet</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>JPlusCaStore_Release</ci>
<ci>JMinusCaStore_Resequestration</ci>
</apply>
<ci>JExternal</ci>
</apply>
<ci>JMinusCa_if_Out</ci>
</apply>
<ci>JPlusCa_if_In</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="Ca_if_delta" component_2="Calcium_Handling"/>
<map_variables variable_1="JNet" variable_2="J_Ca_if"/>
<map_variables variable_1="JExternal" variable_2="J_Ca_if_External"/>
</connection>
<connection>
<map_components component_1="Ca_if_delta" component_2="Ca_Intrusions"/>
<map_variables variable_1="JPlusCa_if_In" variable_2="J_in"/>
</connection>
<connection>
<map_components component_1="Ca_if_delta" component_2="Ca_Extrusions"/>
<map_variables variable_1="JMinusCa_if_Out" variable_2="J_out"/>
</connection>
<connection>
<map_components component_1="Ca_if_delta" component_2="CaStore_Release"/>
<map_variables variable_1="JPlusCaStore_Release" variable_2="J_rel"/>
</connection>
<connection>
<map_components component_1="Ca_if_delta" component_2="CaStore_Resequestration"/>
<map_variables variable_1="JMinusCaStore_Resequestration" variable_2="J_res"/>
</connection>
<component name="CaStore_Release">
<variable name="qrel_k2" units="per_s" public_interface="in"/>
<variable name="IP3" units="uM" public_interface="in" />
<variable name="qrel_k1" units="uM" public_interface="in"/>
<variable name="Ca_st" units="uM" public_interface="in" />
<variable name="J_rel" units="uM_per_s" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_rel</ci>
<apply>
<times/>
<ci>qrel_k2</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>IP3</ci>
<apply>
<plus/>
<ci>IP3</ci>
<ci>qrel_k1</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_st</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="CaStore_Release" component_2="Calcium_Handling"/>
<map_variables variable_1="qrel_k2" variable_2="qrel_k2"/>
<map_variables variable_1="IP3" variable_2="IP3"/>
<map_variables variable_1="qrel_k1" variable_2="qrel_k1"/>
</connection>
<connection>
<map_components component_1="CaStore_Release" component_2="Ca_st"/>
<map_variables variable_1="Ca_st" variable_2="concentration"/>
</connection>
<component name="CaStore_Resequestration">
<variable name="qres_k1" units="uM_per_s" public_interface="in"/>
<variable name="Ca_if" units="uM" public_interface="in" />
<variable name="qres_k2" units="uM" public_interface="in" />
<variable name="qres_k3" units="per_uM_per_s" public_interface="in"/>
<variable name="Ca_st" units="uM" public_interface="in"/>
<variable name="J_res" units="uM_per_s" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_res</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>qres_k1</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_if</ci>
<apply>
<plus/>
<ci>Ca_if</ci>
<ci>qres_k2</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>qres_k3</ci>
<apply>
<power/>
<ci>Ca_st</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="CaStore_Resequestration" component_2="Calcium_Handling"/>
<map_variables variable_1="qres_k2" variable_2="qres_k2"/>
<map_variables variable_1="qres_k1" variable_2="qres_k1"/>
<map_variables variable_1="qres_k3" variable_2="qres_k3"/>
</connection>
<connection>
<map_components component_1="CaStore_Resequestration" component_2="Ca_st"/>
<map_variables variable_1="Ca_st" variable_2="concentration"/>
</connection>
<connection>
<map_components component_1="CaStore_Resequestration" component_2="Ca_if"/>
<map_variables variable_1="Ca_if" variable_2="concentration"/>
</connection>
<component name="Ca_Extrusions">
<variable name="qout_basal_vmax" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qout_basal_Km" units="uM" public_interface="in" private_interface="out"/>
<variable name="qout_basal_n" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="qout_basal" units="uM_per_s" private_interface="in" />
<variable name="qout_pump_vmax" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qout_pump_Km" units="uM" public_interface="in" private_interface="out"/>
<variable name="qout_pump_n" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="qout_pump" units="uM_per_s" private_interface="in" />
<variable name="qout_exch_vmax" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qout_exch_Km" units="uM" public_interface="in" private_interface="out"/>
<variable name="qout_exch_n" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="qout_exch" units="uM_per_s" private_interface="in" />
<variable name="Ca_if_rest" units="uM" public_interface="in"/>
<variable name="Ca_if" units="uM" public_interface="in" private_interface="out"/>
<variable name="J_out" units="uM_per_s" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_out</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>qout_basal</ci>
<ci>qout_pump</ci>
<ci>qout_exch</ci>
</apply>
<apply>
<gt/>
<ci>Ca_if</ci>
<ci>Ca_if_rest</ci>
</apply>
</piece>
<otherwise>
<cn cellml:units="uM_per_s">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<connection>
<map_components component_1="Ca_Extrusions" component_2="Calcium_Handling"/>
<map_variables variable_1="qout_basal_vmax" variable_2="qout_basal_vmax"/>
<map_variables variable_1="qout_basal_Km" variable_2="qout_basal_Km" />
<map_variables variable_1="qout_basal_n" variable_2="qout_basal_n" />
<map_variables variable_1="qout_pump_vmax" variable_2="qout_pump_vmax"/>
<map_variables variable_1="qout_pump_Km" variable_2="qout_pump_Km" />
<map_variables variable_1="qout_pump_n" variable_2="qout_pump_n" />
<map_variables variable_1="qout_exch_vmax" variable_2="qout_exch_vmax"/>
<map_variables variable_1="qout_exch_Km" variable_2="qout_exch_Km" />
<map_variables variable_1="qout_exch_n" variable_2="qout_exch_n" />
<map_variables variable_1="Ca_if_rest" variable_2="Ca_if_rest" />
</connection>
<connection>
<map_components component_1="Ca_Extrusions" component_2="Ca_if"/>
<map_variables variable_1="Ca_if" variable_2="concentration"/>
</connection>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Principled_Base/Template_HillFunction_uM.cellml">
<component name="Ca_Extrusion_Basal" component_ref="Template_HillFunction_uM"/>
</import>
<connection>
<map_components component_1="Ca_Extrusions" component_2="Ca_Extrusion_Basal"/>
<map_variables variable_1="qout_basal_vmax" variable_2="Vmax"/>
<map_variables variable_1="qout_basal_Km" variable_2="Km"/>
<map_variables variable_1="qout_basal_n" variable_2="n"/>
<map_variables variable_1="qout_basal" variable_2="v"/>
<map_variables variable_1="Ca_if" variable_2="S"/>
</connection>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Principled_Base/Template_HillFunction_uM.cellml">
<component name="Ca_Extrusion_Pump" component_ref="Template_HillFunction_uM"/>
</import>
<connection>
<map_components component_1="Ca_Extrusions" component_2="Ca_Extrusion_Pump"/>
<map_variables variable_1="qout_pump_vmax" variable_2="Vmax"/>
<map_variables variable_1="qout_pump_Km" variable_2="Km"/>
<map_variables variable_1="qout_pump_n" variable_2="n"/>
<map_variables variable_1="qout_pump" variable_2="v"/>
<map_variables variable_1="Ca_if" variable_2="S"/>
</connection>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Principled_Base/Template_HillFunction_uM.cellml">
<component name="Ca_Extrusion_Exch" component_ref="Template_HillFunction_uM"/>
</import>
<connection>
<map_components component_1="Ca_Extrusions" component_2="Ca_Extrusion_Exch"/>
<map_variables variable_1="qout_exch_vmax" variable_2="Vmax"/>
<map_variables variable_1="qout_exch_Km" variable_2="Km"/>
<map_variables variable_1="qout_exch_n" variable_2="n"/>
<map_variables variable_1="qout_exch" variable_2="v"/>
<map_variables variable_1="Ca_if" variable_2="S"/>
</connection>
<component name="Ca_Intrusions">
<variable name="epsilon" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="tau" units="N_per_m2" public_interface="in" private_interface="out"/>
<variable name="l" units="meter" public_interface="in" private_interface="out"/>
<variable name="qinw_delta" units="N_per_m" public_interface="in" private_interface="out"/>
<variable name="qinw_f" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="k" units="N_m_per_K" public_interface="in" private_interface="out"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="cac" units="per_m2" public_interface="in" private_interface="out"/>
<variable name="qin_max" units="uM_per_s" public_interface="in" private_interface="out"/>
<variable name="qin_alpha" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="J_chan" units="uM_per_s" private_interface="in"/>
<variable name="qin_kcce" units="per_uM_per_s" public_interface="in" private_interface="out" />
<variable name="Ca_st_rest" units="uM" public_interface="in" private_interface="out"/>
<variable name="Ca_st" units="uM" public_interface="in" private_interface="out"/>
<variable name="Ca_ex" units="uM" public_interface="in" private_interface="out"/>
<variable name="Ca_if" units="uM" public_interface="in" private_interface="out"/>
<variable name="J_cce" units="uM_per_s" private_interface="in"/>
<variable name="J_in" units="uM_per_s" public_interface="out" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_in</ci>
<apply>
<plus/>
<ci>J_cce</ci>
<ci>J_chan</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="Ca_Intrusions" component_2="Calcium_Handling"/>
<map_variables variable_1="epsilon" variable_2="epsilon"/>
<map_variables variable_1="tau" variable_2="tau"/>
<map_variables variable_1="l" variable_2="l"/>
<map_variables variable_1="qinw_delta" variable_2="qinw_delta"/>
<map_variables variable_1="qinw_f" variable_2="qinw_f"/>
<map_variables variable_1="k" variable_2="k"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="cac" variable_2="cac"/>
<map_variables variable_1="qin_max" variable_2="qin_max"/>
<map_variables variable_1="qin_alpha" variable_2="qin_alpha"/>
<map_variables variable_1="qin_kcce" variable_2="qin_kcce"/>
<map_variables variable_1="Ca_st_rest" variable_2="Ca_st_rest"/>
<map_variables variable_1="Ca_ex" variable_2="Ca_ex"/>
</connection>
<connection>
<map_components component_1="Ca_Intrusions" component_2="Ca_if"/>
<map_variables variable_1="Ca_if" variable_2="concentration"/>
</connection>
<connection>
<map_components component_1="Ca_Intrusions" component_2="Ca_st"/>
<map_variables variable_1="Ca_st" variable_2="concentration"/>
</connection>
<component name="Ca_Intrusion_StressSensitiveChannels">
<variable name="epsilon" units="dimensionless" public_interface="in"/>
<variable name="tau" units="N_per_m2" public_interface="in" />
<variable name="l" units="meter" public_interface="in" />
<variable name="qinw_delta" units="N_per_m" public_interface="in" />
<variable name="qinw_f" units="dimensionless" public_interface="in" />
<variable name="k" units="N_m_per_K" public_interface="in" />
<variable name="T" units="kelvin" public_interface="in" />
<variable name="cac" units="per_m2" public_interface="in" />
<variable name="qin_max" units="uM_per_s" public_interface="in" />
<variable name="qin_alpha" units="dimensionless" public_interface="in" />
<variable name="qin_w" units="dimensionless"/>
<variable name="qinw_a" units="N_per_m"/>
<variable name="J_chan" units="uM_per_s" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>qinw_a</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon</ci>
<ci>tau</ci>
<ci>l</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">16</cn>
<apply>
<power/>
<ci>qinw_delta</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>epsilon</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>tau</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>l</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>qin_w</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>qinw_f</ci>
<apply>
<power/>
<apply>
<minus/>
<ci>qinw_a</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>qinw_delta</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">8</cn>
<ci>k</ci>
<ci>T</ci>
<ci>cac</ci>
<ci>qinw_a</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_chan</ci>
<apply>
<divide/>
<ci>qin_max</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>qin_alpha</ci>
<apply>
<power/>
<exponentiale/>
<ci>qin_w</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="Ca_Intrusions" component_2="Ca_Intrusion_StressSensitiveChannels"/>
<map_variables variable_1="epsilon" variable_2="epsilon"/>
<map_variables variable_1="tau" variable_2="tau"/>
<map_variables variable_1="l" variable_2="l"/>
<map_variables variable_1="qinw_delta" variable_2="qinw_delta"/>
<map_variables variable_1="qinw_f" variable_2="qinw_f"/>
<map_variables variable_1="k" variable_2="k"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="cac" variable_2="cac"/>
<map_variables variable_1="qin_max" variable_2="qin_max"/>
<map_variables variable_1="qin_alpha" variable_2="qin_alpha"/>
<map_variables variable_1="J_chan" variable_2="J_chan"/>
</connection>
<component name="Ca_Intrusion_CCE">
<variable name="qin_kcce" units="per_uM_per_s" public_interface="in" />
<variable name="Ca_st_rest" units="uM" public_interface="in" />
<variable name="Ca_st" units="uM" public_interface="in" />
<variable name="Ca_ex" units="uM" public_interface="in" />
<variable name="Ca_if" units="uM" public_interface="in" />
<variable name="J_cce" units="uM_per_s" public_interface="out" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_cce</ci>
<apply>
<times/>
<ci>qin_kcce</ci>
<apply>
<minus/>
<ci>Ca_st_rest</ci>
<ci>Ca_st</ci>
</apply>
<apply>
<minus/>
<ci>Ca_ex</ci>
<ci>Ca_if</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="Ca_Intrusions" component_2="Ca_Intrusion_CCE"/>
<map_variables variable_1="qin_kcce" variable_2="qin_kcce"/>
<map_variables variable_1="Ca_st_rest" variable_2="Ca_st_rest"/>
<map_variables variable_1="Ca_st" variable_2="Ca_st"/>
<map_variables variable_1="Ca_ex" variable_2="Ca_ex"/>
<map_variables variable_1="Ca_if" variable_2="Ca_if"/>
<map_variables variable_1="J_cce" variable_2="J_cce"/>
</connection>
</model>
