- Author:
- Hanne Nielsen <hnie010@aucklanduni.ac.nz>
- Date:
- 2011-09-02 16:16:08+12:00
- Desc:
- Added images in ai svg and png images, xul file and clickable session files
- Permanent Source URI:
- https://models.physiomeproject.org/w/hnielsen/dupont_goldbeter_1993/rawfile/cb1d8e61be5595559ec5cd736cfd8d7ddb20eca5/dupont_goldbeter_1993b.cellml
<?xml version="1.0"?>
<!--
This CellML file was generated on 9/2/2011 at 3:03:04 at PM using:
COR (0.9.31.1409)
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="dupont_goldbeter_1993" name="dupont_goldbeter_1993">
<units name="minute">
<unit multiplier="60" units="second"/>
</units>
<units name="per_minute">
<unit exponent="-1" units="minute"/>
</units>
<units name="micromole">
<unit prefix="micro" units="mole"/>
</units>
<units name="micromolar">
<unit units="micromole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="micromolar_per_minute">
<unit units="micromolar"/>
<unit exponent="-1" units="minute"/>
</units>
<units name="micro_m">
<unit prefix="micro" units="metre"/>
</units>
<units name="micro_m_squared_per_second">
<unit exponent="2" units="micro_m"/>
<unit exponent="-1" units="second"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="minute"/>
</component>
<component name="Z">
<variable cmeta:id="Z_Z" initial_value="0.37" name="Z" public_interface="out" units="micromolar"/>
<variable name="Y" public_interface="in" units="micromolar"/>
<variable name="V_in" public_interface="in" units="micromolar_per_minute"/>
<variable name="V_2" public_interface="in" units="micromolar_per_minute"/>
<variable name="V_3" public_interface="in" units="micromolar_per_minute"/>
<variable initial_value="1" name="k_f" public_interface="out" units="per_minute"/>
<variable initial_value="10" name="k" units="per_minute"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Z</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V_in</ci>
<ci>V_2</ci>
</apply>
<ci>V_3</ci>
<apply>
<times/>
<ci>k_f</ci>
<ci>Y</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k</ci>
<ci>Z</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Y">
<variable cmeta:id="Y_Y" initial_value="1.87" name="Y" public_interface="out" units="micromolar"/>
<variable name="V_2" public_interface="in" units="micromolar_per_minute"/>
<variable name="V_3" public_interface="in" units="micromolar_per_minute"/>
<variable name="k_f" public_interface="in" units="per_minute"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Y</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>V_2</ci>
<ci>V_3</ci>
</apply>
<apply>
<times/>
<ci>k_f</ci>
<ci>Y</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_in">
<variable name="V_in" public_interface="out" units="micromolar_per_minute"/>
<variable initial_value="3.4" name="V_0" units="micromolar_per_minute"/>
<variable initial_value="3.4" name="V_1" units="micromolar_per_minute"/>
<variable initial_value="0.4" name="beta" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_in</ci>
<apply>
<plus/>
<ci>V_0</ci>
<apply>
<times/>
<ci>V_1</ci>
<ci>beta</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_2">
<variable name="V_2" public_interface="out" units="micromolar_per_minute"/>
<variable initial_value="50" name="V_M2" units="micromolar_per_minute"/>
<variable name="Z" public_interface="in" units="micromolar"/>
<variable initial_value="1" name="k_2" units="micromolar"/>
<variable initial_value="2" name="n" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_2</ci>
<apply>
<times/>
<ci>V_M2</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>Z</ci>
<ci>n</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>k_2</ci>
<ci>n</ci>
</apply>
<apply>
<power/>
<ci>Z</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_3">
<variable name="V_3" public_interface="out" units="micromolar_per_minute"/>
<variable initial_value="650" name="V_M3" units="micromolar_per_minute"/>
<variable name="Z" public_interface="in" units="micromolar"/>
<variable name="Y" public_interface="in" units="micromolar"/>
<variable initial_value="2" name="m" units="dimensionless"/>
<variable initial_value="4" name="p" units="dimensionless"/>
<variable initial_value="0.9" name="K_A" units="micromolar"/>
<variable initial_value="2" name="K_R" units="micromolar"/>
<variable name="beta" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_3</ci>
<apply>
<times/>
<ci>beta</ci>
<ci>V_M3</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>Y</ci>
<ci>m</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_R</ci>
<ci>m</ci>
</apply>
<apply>
<power/>
<ci>Y</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<power/>
<ci>Z</ci>
<ci>p</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_A</ci>
<ci>p</ci>
</apply>
<apply>
<power/>
<ci>Z</ci>
<ci>p</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="Z"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="Y"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="V_in"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="V_2"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="V_3"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Z" component_2="Y"/>
<map_variables variable_1="k_f" variable_2="k_f"/>
<map_variables variable_1="Y" variable_2="Y"/>
</connection>
<connection>
<map_components component_1="Z" component_2="V_3"/>
<map_variables variable_1="Z" variable_2="Z"/>
<map_variables variable_1="V_3" variable_2="V_3"/>
</connection>
<connection>
<map_components component_1="Z" component_2="V_2"/>
<map_variables variable_1="Z" variable_2="Z"/>
<map_variables variable_1="V_2" variable_2="V_2"/>
</connection>
<connection>
<map_components component_1="Z" component_2="V_in"/>
<map_variables variable_1="V_in" variable_2="V_in"/>
</connection>
<connection>
<map_components component_1="Y" component_2="V_2"/>
<map_variables variable_1="V_2" variable_2="V_2"/>
</connection>
<connection>
<map_components component_1="Y" component_2="V_3"/>
<map_variables variable_1="V_3" variable_2="V_3"/>
<map_variables variable_1="Y" variable_2="Y"/>
</connection>
<connection>
<map_components component_1="V_3" component_2="V_in"/>
<map_variables variable_1="beta" variable_2="beta"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:nodeID="n1"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Cell Calcium</title></rdf:Description><rdf:Description rdf:nodeID="n2"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:nodeID="n3"/></N></rdf:Description><rdf:Description rdf:about="#dupont_goldbeter_1993"><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n4"/></simulation><cmeta:bio_entity xml:lang="en">Hepatocytes</cmeta:bio_entity><cmeta:bio_entity xml:lang="en">Liver</cmeta:bio_entity><cmeta:species xml:lang="en">Human</cmeta:species><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n5"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n6"/></reference></rdf:Description><rdf:Description rdf:nodeID="n6"><Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">8370067</Pubmed_id><JournalArticle xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n7"/></JournalArticle></rdf:Description><rdf:Description rdf:nodeID="n8"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Hanne</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Nielsen</Family></rdf:Description><rdf:Description rdf:nodeID="n9"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:nodeID="n10"/></N></rdf:Description><rdf:Description rdf:nodeID="n11"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2011-09-02</W3CDTF></rdf:Description><rdf:Description rdf:nodeID="n12"><rdf:_1><rdf:Description rdf:nodeID="n13"/></rdf:_1><rdf:_2><rdf:Description rdf:nodeID="n14"/></rdf:_2><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type></rdf:Description><rdf:Description rdf:nodeID="n10"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">G</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Dupont</Family></rdf:Description><rdf:Description rdf:nodeID="n15"><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">5</endingValue></rdf:Description><rdf:Description rdf:nodeID="n3"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">A</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Goldbeter</Family></rdf:Description><rdf:Description rdf:nodeID="n16"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2011-09-02</W3CDTF></rdf:Description><rdf:Description rdf:nodeID="n4"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n17"/></boundIntervals></rdf:Description><rdf:Description rdf:nodeID="n13"><Person xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n9"/></Person></rdf:Description><rdf:Description rdf:nodeID="n5"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n18"/></subject></rdf:Description><rdf:Description rdf:about=""><created xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:nodeID="n11"/></created><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n19"/></creator></rdf:Description><rdf:Description rdf:nodeID="n18"><rdf:value><rdf:Description rdf:nodeID="n20"/></rdf:value><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type></rdf:Description><rdf:Description rdf:nodeID="n17"><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest><rdf:first><rdf:Description rdf:nodeID="n15"/></rdf:first></rdf:Description><rdf:Description rdf:nodeID="n20"><rdf:_1 xml:lang="en">liver</rdf:_1><rdf:_3 xml:lang="en">hepatolocyte</rdf:_3><rdf:_2 xml:lang="en">hepatology</rdf:_2><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/></rdf:type></rdf:Description><rdf:Description rdf:nodeID="n19"><ORG xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:nodeID="n21"/></ORG><EMAIL xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:nodeID="n22"/></EMAIL><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:nodeID="n8"/></N></rdf:Description><rdf:Description rdf:nodeID="n14"><Person xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n2"/></Person></rdf:Description><rdf:Description rdf:nodeID="n21"><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Auckland Bioengineering Institute</Orgunit><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The University of Auckland</Orgname></rdf:Description><rdf:Description rdf:nodeID="n22"><rdf:value xml:lang="en">hnie010@aucklanduni.ac.nz</rdf:value><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type></rdf:Description><rdf:Description rdf:nodeID="n7"><issued xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:nodeID="n16"/></issued><first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">311</first_page><Journal xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n1"/></Journal><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n12"/></creator><last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">322</last_page><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">
One-pool model for Ca2+ oscillations involving Ca2+ and inositol 1,4,5-trisphosphate as co-agonists for Ca2+ release
</title><volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">14(4)</volume></rdf:Description></rdf:RDF></model>
