- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2013-05-04 07:40:04+12:00
- Desc:
- adding initial TODO list to keep track of what I need to do to get things working with more recent tools than my original CellMLSimulator that I used in this paper
- Permanent Source URI:
- https://models.physiomeproject.org/w/andre/nickerson-2008/rawfile/d6328d18c94e9dad70f4d0e4b250e89429773b62/cellml/models/2004_tenTusscher-version-2/variable_values.xml
<?xml version="1.0" encoding="iso-8859-1"?>
<model
name="ten_tusscher_model_2004_epi_variable_values"
cmeta:id="ten_tusscher_model_2004_epi_variable_values"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="">
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Nickerson</vCard:Family>
<vCard:Given>David</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>david.nickerson@nus.edu.sg</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>National University of Singapore</vCard:Orgname>
<vCard:Orgunit>Division of Bioengineering</vCard:Orgunit>
</vCard:ORG>
</dc:creator>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2006-10-18</dcterms:W3CDTF>
</dcterms:created>
<dc:publisher>
Division of Bioengineering, National University of Singapore
</dc:publisher>
</rdf:Description>
<rdf:Description rdf:about="#ten_tusscher_model_2004_epi_variable_values">
<dc:title>
Default paramter values for ten Tuscher et. al (2004) model.
</dc:title>
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
The default parameter set for the ten Tusscher et. al (2004) human
ventricular cell model. These default values correspond to the
epicardial variant of the model.
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>David Nickerson</vCard:FN>
</dc:creator>
</cmeta:comment>
<bqs:reference rdf:parseType="Resource">
<bqs:Pubmed_id>14656705</bqs:Pubmed_id>
<bqs:JournalArticle rdf:parseType="Resource">
<dc:creator>
<rdf:Seq>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>ten Tusscher</vCard:Family>
<vCard:Given>K</vCard:Given>
<vCard:Other>H</vCard:Other>
<vCard:Other>W</vCard:Other>
<vCard:Other>J</vCard:Other>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Noble</vCard:Family>
<vCard:Given>D</vCard:Given>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Noble</vCard:Family>
<vCard:Given>P</vCard:Given>
<vCard:Other>J</vCard:Other>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Panfilov</vCard:Family>
<vCard:Given>A</vCard:Given>
<vCard:Other>V</vCard:Other>
</vCard:N>
</bqs:Person>
</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:title>
A model for human ventricular tissue
</dc:title>
<dcterms:issued rdf:parseType="Resource">
<dcterms:W3CDTF>2004-04</dcterms:W3CDTF>
</dcterms:issued>
<bqs:Journal rdf:parseType="Resource">
<dc:title>American Journal of Physiology</dc:title>
</bqs:Journal>
<bqs:volume>286</bqs:volume>
<bqs:first_page>H1573</bqs:first_page>
<bqs:last_page>H1589</bqs:last_page>
</bqs:JournalArticle>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<import xlink:href="../common/units.xml">
<units name="ms" units_ref="ms"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="uA_per_mmsq" units_ref="uA_per_mmsq"/>
<units name="uA_per_mmcu" units_ref="uA_per_mmcu"/>
<units name="mM_per_ms" units_ref="mM_per_ms"/>
<units name="per_mm" units_ref="per_mm"/>
<units name="uF_per_mmsq" units_ref="uF_per_mmsq"/>
<units name="mmcu" units_ref="mmcu"/>
<units name="mS_per_mmsq" units_ref="mS_per_mmsq"/>
<units name="K" units_ref="K"/>
<units name="mm_per_ms" units_ref="mm_per_ms"/>
<units name="per_ms" units_ref="per_ms"/>
</import>
<component name="parameters" cmeta:id="parameters">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#parameters">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
The default model parameters.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable name="Am" initial_value="200" public_interface="out" units="per_mm"/>
<variable name="Cm" initial_value="0.01" public_interface="out" units="uF_per_mmsq"/>
<variable name="Capacitance" initial_value="0.00185" public_interface="out" units="uF_per_mmsq"/>
<variable name="temperature" initial_value="310" public_interface="out" units="K"/>
<!--<variable name="vC" initial_value="0.016404e-3" public_interface="out" units="mmcu"/>
<variable name="vSR" initial_value="0.001094e-3" public_interface="out" units="mmcu"/>-->
<!-- with the change in units we need to use a volume fraction rather than absolute volumes
start with values from Noble 98 model and go from there -->
<variable name="vC" initial_value="0.49" public_interface="out" units="dimensionless"/>
<variable name="vSR" initial_value="0.1" public_interface="out" units="dimensionless"/>
<variable name="g_Na" initial_value="14.838e-2" public_interface="out" units="mS_per_mmsq"/>
<variable name="g_K1" initial_value="5.405e-2" public_interface="out" units="mS_per_mmsq"/>
<variable name="g_to" initial_value="0.294e-2" public_interface="out" units="mS_per_mmsq"/>
<variable name="g_Kr" initial_value="0.096e-2" public_interface="out" units="mS_per_mmsq"/>
<variable name="g_Ks" initial_value="0.245e-2" public_interface="out" units="mS_per_mmsq"/>
<variable name="g_pK" initial_value="0.0146e-2" public_interface="out" units="mS_per_mmsq"/>
<variable name="g_bNa" initial_value="0.29e-5" public_interface="out" units="mS_per_mmsq"/>
<variable name="g_bCa" initial_value="0.592e-5" public_interface="out" units="mS_per_mmsq"/>
<variable name="p_KNa" initial_value="0.03" public_interface="out" units="dimensionless"/>
<variable name="P_NaK" initial_value="1.362e-2" public_interface="out" units="uA_per_mmsq"/>
<variable name="K_mNa" initial_value="40.0" public_interface="out" units="mM"/>
<variable name="K_mK" initial_value="1.0" public_interface="out" units="mM"/>
<variable name="g_CaL" initial_value="1.75e-6" public_interface="out" units="mm_per_ms"/>
<variable name="Bufc" initial_value="0.15" public_interface="out" units="mM"/>
<variable name="Kbufc" initial_value="0.001" public_interface="out" units="mM"/>
<variable name="Bufsr" initial_value="10.0" public_interface="out" units="mM"/>
<variable name="Kbufsr" initial_value="0.3" public_interface="out" units="mM"/>
<variable name="Nao" initial_value="140" public_interface="out" units="mM"/>
<variable name="Ko" initial_value="5.4" public_interface="out" units="mM"/>
<variable name="Cao" initial_value="2.0" public_interface="out" units="mM"/>
<variable name="V_leak" initial_value="0.08e-3" public_interface="out" units="per_ms"/>
<variable name="K_up" initial_value="0.25e-3" public_interface="out" units="mM"/>
<variable name="Vmax_up" initial_value="0.425e-3" public_interface="out" units="mM_per_ms"/>
<variable name="a_rel" initial_value="0.016464" public_interface="out" units="mM_per_ms"/>
<variable name="b_rel" initial_value="0.25" public_interface="out" units="mM"/>
<variable name="c_rel" initial_value="0.008232" public_interface="out" units="mM_per_ms"/>
<variable name="tau_g" initial_value="2" public_interface="out" units="ms"/>
<variable name="g_pCa" initial_value="0.825e-2" public_interface="out" units="uA_per_mmsq"/>
<variable name="K_pCa" initial_value="0.5e-3" public_interface="out" units="mM"/>
<variable name="k_NaCa" initial_value="1.0e1" public_interface="out" units="uA_per_mmsq"/>
<variable name="K_mNai" initial_value="87.5" public_interface="out" units="mM"/>
<variable name="K_mCa" initial_value="1.38" public_interface="out" units="mM"/>
<variable name="k_sat" initial_value="0.1" public_interface="out" units="dimensionless"/>
<variable name="gamma" initial_value="0.35" public_interface="out" units="dimensionless"/>
<variable name="alpha" initial_value="2.5" public_interface="out" units="dimensionless"/>
</component>
<component name="initial_conditions" cmeta:id="initial_conditions">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#initial_conditions">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
The default initial conditions.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable name="V_initial" initial_value="-86.2" public_interface="out" units="mV"/>
<variable name="m_initial" initial_value="0" public_interface="out" units="dimensionless"/>
<variable name="h_initial" initial_value="0.75" public_interface="out" units="dimensionless"/>
<variable name="j_initial" initial_value="0.75" public_interface="out" units="dimensionless"/>
<variable name="s_initial" initial_value="1.0" public_interface="out" units="dimensionless"/>
<variable name="r_initial" initial_value="0.0" public_interface="out" units="dimensionless"/>
<variable name="Xr1_initial" initial_value="0.0" public_interface="out" units="dimensionless"/>
<variable name="Xr2_initial" initial_value="1.0" public_interface="out" units="dimensionless"/>
<variable name="Xs_initial" initial_value="0.0" public_interface="out" units="dimensionless"/>
<variable name="d_initial" initial_value="0.0" public_interface="out" units="dimensionless"/>
<variable name="f_initial" initial_value="1.0" public_interface="out" units="dimensionless"/>
<variable name="fCa_initial" initial_value="1.0" public_interface="out" units="dimensionless"/>
<variable name="g_initial" initial_value="1.0" public_interface="out" units="dimensionless"/>
<variable name="Nai_initial" initial_value="11.6" public_interface="out" units="mM"/>
<variable name="Ki_initial" initial_value="138.3" public_interface="out" units="mM"/>
<variable name="Cai_total_initial" initial_value="0.0064" public_interface="out" units="mM"/>
<variable name="CaSR_total_initial" initial_value="4.2" public_interface="out" units="mM"/>
</component>
</model>
