- Author:
- Dougal Cowan <devnull@localhost>
- Date:
- 2011-06-03 08:51:26+12:00
- Desc:
- Added documentation file
- Permanent Source URI:
- https://models.physiomeproject.org/w/alberto/CorriasPurkinje/rawfile/72bceeb3ab3eee0b714728e2d478b11320c17b8e/purkinje_model.cellml
<model
name="Corrias_rabbit_purkinje_model"
xmlns="http://www.cellml.org/cellml/1.0#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:cellml="http://www.cellml.org/cellml/1.0#">
<units name="conductance_units">
<unit units="siemens" prefix="nano"/>
</units>
<units name="picofarads">
<unit units="farad" prefix="pico"/>
</units>
<units name="voltage_units">
<unit units="volt" prefix="milli"/>
</units>
<units name="volume_units">
<unit units="meter" prefix="micro" exponent="3"/>
</units>
<units name="inverse_voltage_units">
<unit units="voltage_units" exponent="-1"/>
</units>
<units name="inverse_voltage_units_square">
<unit units="voltage_units" exponent="-2"/>
</units>
<units name="Inverse_Voltage_Units_per_time_units">
<unit units="inverse_voltage_units"/>
<unit units="time_units" exponent="-1"/>
</units>
<units name="time_units">
<unit units="second" prefix="milli"/>
</units>
<units name="current_units">
<unit prefix="pico" units="ampere"/>
</units>
<units name="rate_constants_units">
<unit units="time_units" exponent="-1"/>
</units>
<units name="capacitance_units">
<unit units="farad" prefix="pico"/>
</units>
<units name="Temperature_units">
<unit units="kelvin"/>
</units>
<units name="Inverse_Temperature_units_times_conductance">
<unit units="Temperature_units" exponent="-1"/>
<unit units="conductance_units"/>
</units>
<units name="F_units">
<unit units="mole" prefix="micro" exponent="-1"/>
<unit units="coulomb" prefix="micro"/>
</units>
<units name="R_units">
<unit units="joule" prefix="milli"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="molar">
<unit units="mole"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="inverse_millimolar_fourth_power">
<unit units="millimolar" exponent="-4"/>
</units>
<units name="millimolar_power_4">
<unit units="millimolar" exponent="4"/>
</units>
<units name="micromolar_per_time_units">
<unit units="mole" prefix="micro"/>
<unit units="litre" exponent="-1"/>
<unit units="time_units" exponent="-1"/>
</units>
<units name="per_millimolar">
<unit units="litre"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
<units name ="current_per_millimolar_units">
<unit units="current_units"/>
<unit units="per_millimolar"/>
</units>
<units name="millimolar_per_second">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="millimolar_per_second_per_millivolt">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
<unit units="second" exponent="-1"/>
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="millimole_to_nanomole">
<unit units="mole" prefix="nano"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
<units name="microcoulomb_to_picocoulomb">
<unit units="coulomb" prefix="pico"/>
<unit units="coulomb" prefix="micro" exponent="-1"/>
</units>
<units name="molar_to_millimolar">
<unit units="millimolar" />
<unit units="molar" exponent="-1"/>
</units>
<units name="liter_over_cubic_microns">
<unit units="liter" exponent="1"/>
<unit units="volume_units" exponent="-1"/>
</units>
<units name="milliA_over_picoA">
<unit units="molar" exponent="12"/>
<unit units="molar" exponent="-6"/>
</units>
<component name="Time">
<variable name="time" units="time_units" public_interface="out" private_interface="out"/>
</component>
<component name="Environment">
<variable name="T" units="Temperature_units" initial_value="310.0" private_interface="out"/>
<variable name="F" units="F_units" initial_value="96485.3415" public_interface="out" private_interface="out"/>
<variable name="R" units="R_units" initial_value="8314.472" private_interface="out"/>
<variable name="Ca_o" units="millimolar" initial_value="2.0" public_interface="out" private_interface="out"/>
<variable name="Na_o" units="millimolar" initial_value="140" public_interface="out" private_interface="out"/>
<variable name="K_o" units="millimolar" initial_value="5.4" public_interface="out" private_interface="out"/>
<variable name="FoRT" units="inverse_voltage_units" public_interface="out" private_interface="out"/>
<variable name="RToF" units="voltage_units" public_interface="out" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FoRT</ci>
<apply>
<divide/>
<ci>F</ci>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>RToF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="membrane">
<variable cmeta:id="Cm" name="Cm" units="capacitance_units" initial_value="69.0"/>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#Cm">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_capacitance"/>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="membrane_V" name="Vm" units="voltage_units" initial_value="-88.34" private_interface="out"/>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#membrane_V">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_voltage"/>
</rdf:Description>
</rdf:RDF>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<variable name="Ca_i_peripheral" units="millimolar" initial_value="0.00001" public_interface="out" private_interface="out"/>
<variable name="Ca_i_bulk" units="millimolar" initial_value="0.000032" public_interface="out" private_interface="out"/>
<variable name="Ca_sr" units="millimolar" initial_value="0.17" public_interface="out" private_interface="out"/>
<variable name="Na_i" units="millimolar" initial_value="6.7" public_interface="out" private_interface="out"/>
<variable name="K_i" units="millimolar" initial_value="140" public_interface="out" private_interface="out"/>
<variable name="Ca_o" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Na_o" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="K_o" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="RToF" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="FoRT" units="inverse_voltage_units" public_interface="in" private_interface="out"/>
<variable name="F" units="F_units" public_interface="in" private_interface="out"/>
<variable name="i_k1" units="current_units" private_interface="in"/>
<variable name="i_to_fast" units="current_units" private_interface="in"/>
<variable name="i_to_sustained" units="current_units" private_interface="in"/>
<variable name="i_kr" units="current_units" private_interface="in"/>
<variable name="i_ks" units="current_units" private_interface="in"/>
<variable name="i_kb" units="current_units" private_interface="in"/>
<variable name="i_nak" units="current_units" private_interface="in"/>
<variable name="i_cal" units="current_units" private_interface="in"/>
<variable name="i_cat" units="current_units" private_interface="in"/>
<variable name="i_na_fast" units="current_units" private_interface="in"/>
<variable name="i_na_late" units="current_units" private_interface="in"/>
<variable name="i_pmca" units="current_units" private_interface="in"/>
<variable name="i_cab" units="current_units" private_interface="in"/>
<variable name="i_f_na" units="current_units" private_interface="in"/>
<variable name="i_f_k" units="current_units" private_interface="in"/>
<variable name="i_naca" units="current_units" private_interface="in"/>
<variable name="i_nab" units="current_units" private_interface="in"/>
<variable cmeta:id="stimulus" name="i_stim" units="current_units"/>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#stimulus">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current"/>
</rdf:Description>
</rdf:RDF>
<variable name="i_rel_per" units="current_units" private_interface="in" />
<variable name="i_serca_per" units="current_units" private_interface="in"/>
<variable name="i_serca_bulk" units="current_units" private_interface="in"/>
<variable name="i_diff" units="current_units" private_interface="in"/>
<variable name="i_leak" units="current_units" private_interface="in"/>
<variable name="peripheral_volume" units="volume_units" private_interface="out"/>
<variable name="bulk_volume" units="volume_units" private_interface="out"/>
<variable name="diffusable_volume" units="volume_units" private_interface="out"/>
<variable name="sr_volume" units="volume_units" private_interface="out"/>
<variable name="cell_volume" units="volume_units" initial_value="13266.5" private_interface="out"/>
<variable name="bulk_fraction" units="dimensionless" initial_value="0.6" private_interface="out"/>
<variable name="periphery_fraction" units="dimensionless" initial_value="0.2" private_interface="out"/>
<variable name="sr_fraction" units="dimensionless" initial_value="0.06" private_interface="out"/>
<variable initial_value="700" name="stim_start" units="time_units"/>
<variable initial_value="9000000" name="stim_end" units="time_units"/>
<variable initial_value="500" name="stim_period" units="time_units"/>
<variable initial_value="0.5" name="stim_duration" units="time_units"/>
<variable initial_value="-4320.0" name="stim_amplitude" units="current_units"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="current_units">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>bulk_volume</ci>
<apply>
<times/>
<ci>bulk_fraction</ci>
<ci>cell_volume</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>peripheral_volume</ci>
<apply>
<times/>
<ci>periphery_fraction</ci>
<ci>cell_volume</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>sr_volume</ci>
<apply>
<times/>
<ci>sr_fraction</ci>
<ci>cell_volume</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>diffusable_volume</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>bulk_fraction</ci>
<ci>periphery_fraction</ci>
</apply>
<ci>cell_volume</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>i_k1</ci>
<ci>i_to_fast</ci>
<ci>i_to_sustained</ci>
<ci>i_kr</ci>
<ci>i_ks</ci>
<ci>i_kb</ci>
<ci>i_nak</ci>
<ci>i_cal</ci>
<ci>i_cat</ci>
<ci>i_na_fast</ci>
<ci>i_na_late</ci>
<ci>i_pmca</ci>
<ci>i_cab</ci>
<ci>i_f_na</ci>
<ci>i_f_k</ci>
<ci>i_naca</ci>
<ci>i_nab</ci>
<ci>i_stim</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i_peripheral</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_cal</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_cat</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_cab</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>i_rel_per</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_serca_per</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_diff</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_naca</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_pmca</ci>
</apply>
</apply>
<cn cellml:units="molar_to_millimolar">1000</cn>
</apply><!-- end of numerator -->
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>peripheral_volume</ci>
</apply><!--end of denominator -->
</apply><!--end of divide (equation RHS)-->
</apply><!--end of the equation -->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i_bulk</ci>
</apply>
<apply> <divide/>
<apply> <times/>
<apply>
<plus/>
<apply><times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_serca_bulk</ci>
</apply>
<ci>i_diff</ci>
<ci>i_leak</ci>
</apply>
<cn cellml:units="molar_to_millimolar">1000</cn>
</apply><!-- end of numerator -->
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>bulk_volume</ci>
</apply><!--end of denominator -->
</apply><!--end of divide (equation RHS)-->
</apply><!--end of the equation -->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_sr</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply><times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_rel_per</ci>
</apply>
<apply><times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_leak</ci>
</apply>
<ci>i_serca_bulk</ci>
<ci>i_serca_per</ci>
</apply>
<cn cellml:units="molar_to_millimolar">1000</cn>
</apply><!-- end of numerator -->
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>sr_volume</ci>
</apply><!--end of denominator -->
</apply><!--end of divide (equation RHS)-->
</apply><!--end of the equation -->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply><times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_to_fast</ci>
</apply>
<apply><times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_to_sustained</ci>
</apply>
<apply><times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_kr</ci>
</apply>
<apply> <times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_ks</ci>
</apply>
<apply> <times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_k1</ci>
</apply>
<apply> <times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_kb</ci>
</apply>
<apply> <times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_f_k</ci>
</apply>
<apply><times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_stim</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_nak</ci>
</apply>
</apply>
<cn cellml:units="molar_to_millimolar">1000</cn>
</apply><!-- end of numerator -->
<apply>
<times/>
<ci>F</ci>
<ci>diffusable_volume</ci>
</apply><!--end of denominator -->
</apply><!--end of divide (equation RHS)-->
</apply><!--end of the equation -->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_na_fast</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_na_late</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-3</cn>
<ci>i_nak</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-3</cn>
<ci>i_naca</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_f_na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">-1</cn>
<ci>i_nab</ci>
</apply>
</apply>
<cn cellml:units="molar_to_millimolar">1000</cn>
</apply><!-- end of numerator -->
<apply>
<times/>
<ci>F</ci>
<ci>diffusable_volume</ci>
</apply><!--end of denominator -->
</apply><!--end of divide (equation RHS)-->
</apply><!--end of the equation -->
</math>
</component><!-- end of membrane component -->
<component name="x_Ttype">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_inf_Ttype" units="dimensionless"/>
<variable name="tau_x_Ttype" initial_value="1.0" units="time_units"/>
<variable name="x_Ttype" units="dimensionless" initial_value="0.001337" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_inf_Ttype</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">47.8</cn>
</apply>
<cn cellml:units="voltage_units">-5.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x_Ttype</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_inf_Ttype</ci>
<ci>x_Ttype</ci>
</apply>
<ci>tau_x_Ttype</ci>
</apply>
</apply>
</math>
</component>
<component name="y_Ttype">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_Ttype" units="dimensionless"/>
<variable name="tau_y_Ttype" units="time_units"/>
<variable name="y_Ttype" units="dimensionless" initial_value="0.01" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_Ttype</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">67.9</cn>
</apply>
<cn cellml:units="voltage_units">3.87</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y_Ttype</ci>
<apply>
<times/>
<cn cellml:units="time_units">1.42271</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="inverse_voltage_units">-0.05119</cn>
<ci>Vm</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_Ttype</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_Ttype</ci>
<ci>y_Ttype</ci>
</apply>
<ci>tau_y_Ttype</ci>
</apply>
</apply>
</math>
</component>
<component name="i_cat">
<variable name="i_cat" units="current_units" public_interface="out"/>
<variable name="E_Ca" units="voltage_units"/>
<variable name="G_max_Ttype" units="conductance_units" initial_value="0.9"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_Ttype" units="dimensionless" private_interface="in"/>
<variable name="y_Ttype" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i_peripheral" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i_peripheral</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_cat</ci>
<apply>
<times/>
<ci>G_max_Ttype</ci>
<ci>x_Ttype</ci>
<ci>y_Ttype</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_Ltype">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_inf_Ltype" units="dimensionless"/>
<variable name="tau_x_Ltype" initial_value="0.7" units="time_units"/>
<variable name="x_Ltype" units="dimensionless" initial_value="0.000003" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_inf_Ltype</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">14.6</cn>
</apply>
<cn cellml:units="voltage_units">-5.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x_Ltype</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_inf_Ltype</ci>
<ci>x_Ltype</ci>
</apply>
<ci>tau_x_Ltype</ci>
</apply>
</apply>
</math>
</component>
<component name="y_Ltype">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_Ltype" units="dimensionless"/>
<variable name="tau_y_Ltype" units="time_units"/>
<variable name="y_Ltype" units="dimensionless" initial_value="0.1" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_Ltype</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">31.0</cn>
</apply>
<cn cellml:units="voltage_units">5.54</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y_Ltype</ci>
<apply><divide/>
<cn cellml:units="time_units">25.1</cn>
<apply><plus/>
<cn cellml:units="dimensionless">0.04</cn>
<apply><times/>
<cn cellml:units="dimensionless">0.7</cn>
<apply><exp/>
<apply><times/>
<cn cellml:units="dimensionless">-1</cn>
<apply><power/>
<apply><times/>
<cn cellml:units="inverse_voltage_units">0.028</cn>
<apply><plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">14.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply><!-- end of denominator -->
</apply><!-- end of divide -->
</apply> <!-- end of tau-->
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_Ltype</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_Ltype</ci>
<ci>y_Ltype</ci>
</apply>
<ci>tau_y_Ltype</ci>
</apply>
</apply>
</math>
</component>
<component name="y_ca_Ltype">
<variable name="Ca_i_peripheral" units="millimolar" public_interface="in"/>
<variable name="y_ca_inf_Ltype" units="dimensionless"/>
<variable name="tau_y_ca_Ltype" units="time_units"/>
<variable name="y_ca_Ltype" units="dimensionless" initial_value="0.7" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_ca_inf_Ltype</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.4</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.6</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_i_peripheral</ci>
<cn cellml:units="millimolar">0.0001</cn>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y_ca_Ltype</ci>
<apply>
<plus/>
<cn cellml:units="time_units">2.0</cn>
<apply>
<divide/>
<cn cellml:units="time_units">80.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_i_peripheral</ci>
<cn cellml:units="millimolar">0.0001</cn>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_ca_Ltype</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_ca_inf_Ltype</ci>
<ci>y_ca_Ltype</ci>
</apply>
<ci>tau_y_ca_Ltype</ci>
</apply>
</apply>
</math>
</component>
<component name="i_cal">
<variable name="i_cal" units="current_units" public_interface="out"/>
<variable name="E_Ca" units="voltage_units"/>
<variable name="G_max_Ltype" units="conductance_units" initial_value="5.4"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_Ltype" units="dimensionless" private_interface="in"/>
<variable name="y_Ltype" units="dimensionless" private_interface="in"/>
<variable name="y_ca_Ltype" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i_peripheral" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i_peripheral</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_cal</ci>
<apply>
<times/>
<ci>G_max_Ltype</ci>
<ci>x_Ltype</ci>
<ci>y_Ltype</ci>
<ci>y_ca_Ltype</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_to_fast">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_inf_to_fast" units="dimensionless"/>
<variable name="tau_x_to_fast" initial_value="5.0" units="time_units"/>
<variable name="x_to_fast" units="dimensionless" initial_value="0.0" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_inf_to_fast</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">-7.0</cn>
</apply>
<cn cellml:units="voltage_units">-9.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x_to_fast</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_inf_to_fast</ci>
<ci>x_to_fast</ci>
</apply>
<ci>tau_x_to_fast</ci>
</apply>
</apply>
</math>
</component>
<component name="y_to_fast">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_to_fast" units="dimensionless"/>
<variable name="tau_y_to_fast" initial_value="350.0" units="time_units"/>
<variable name="y_to_fast" units="dimensionless" initial_value="0.7" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_to_fast</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">27.5</cn>
</apply>
<cn cellml:units="voltage_units">8.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_to_fast</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_to_fast</ci>
<ci>y_to_fast</ci>
</apply>
<ci>tau_y_to_fast</ci>
</apply>
</apply>
</math>
</component>
<component name="i_to_fast">
<variable name="i_to_fast" units="current_units" public_interface="out"/>
<variable name="E_k" units="voltage_units"/>
<variable name="G_max_to_fast" units="conductance_units" initial_value="10.0"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_to_fast" units="dimensionless" private_interface="in"/>
<variable name="y_to_fast" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_k</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_to_fast</ci>
<apply>
<times/>
<ci>G_max_to_fast</ci>
<ci>x_to_fast</ci>
<ci>y_to_fast</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_k</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_to_sustained">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_to_sustained" units="dimensionless" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_to_sustained</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="voltage_units">5.0</cn>
<ci>Vm</ci>
</apply>
<cn cellml:units="voltage_units">17.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_to_sustained">
<variable name="i_to_sustained" units="current_units" public_interface="out"/>
<variable name="E_k" units="voltage_units"/>
<variable name="G_max_to_sustained" units="conductance_units" initial_value="3.0"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_to_sustained" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_k</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_to_sustained</ci>
<apply>
<times/>
<ci>G_max_to_sustained</ci>
<ci>x_to_sustained</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_k</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_na_fast">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_inf_na_fast" units="dimensionless"/>
<variable name="tau_x_na_fast" initial_value="0.005" units="time_units"/>
<variable name="x_na_fast" units="dimensionless" initial_value="0.000007" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_inf_na_fast</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">25.0</cn>
</apply>
<cn cellml:units="voltage_units">-5.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x_na_fast</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_inf_na_fast</ci>
<ci>x_na_fast</ci>
</apply>
<ci>tau_x_na_fast</ci>
</apply>
</apply>
</math>
</component>
<component name="y_na_fast">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_na_fast" units="dimensionless"/>
<variable name="tau_y_na_fast" initial_value="2.0" units="time_units"/>
<variable name="y_na_fast" units="dimensionless" initial_value="0.978861" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_na_fast</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">69.0</cn>
</apply>
<cn cellml:units="voltage_units">3.96</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_na_fast</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_na_fast</ci>
<ci>y_na_fast</ci>
</apply>
<ci>tau_y_na_fast</ci>
</apply>
</apply>
</math>
</component>
<component name="i_na_fast">
<variable name="i_na_fast" units="current_units" public_interface="out"/>
<variable name="E_na" units="voltage_units"/>
<variable name="G_max_na_fast" units="conductance_units" initial_value="1140.0"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_na_fast" units="dimensionless" private_interface="in"/>
<variable name="y_na_fast" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_na</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_na_fast</ci>
<apply>
<times/>
<ci>G_max_na_fast</ci>
<ci>x_na_fast</ci>
<ci>y_na_fast</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_na_late">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_inf_na_late" units="dimensionless"/>
<variable name="tau_x_na_late" initial_value="15.0" units="time_units"/>
<variable name="x_na_late" units="dimensionless" initial_value="0.000012" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_inf_na_late</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">30.0</cn>
</apply>
<cn cellml:units="voltage_units">-5.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x_na_late</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_inf_na_late</ci>
<ci>x_na_late</ci>
</apply>
<ci>tau_x_na_late</ci>
</apply>
</apply>
</math>
</component>
<component name="y_na_late">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_na_late" units="dimensionless"/>
<variable name="tau_y_na_late" units="time_units"/>
<variable name="y_na_late" units="dimensionless" initial_value="0.864489" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_na_late</ci>
<apply><plus/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.9</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">75.6</cn>
</apply>
<cn cellml:units="voltage_units">6.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>tau_y_na_late</ci>
<apply><plus/>
<cn cellml:units="time_units">120.0</cn>
<apply><times/>
<cn cellml:units="time_units">1.0</cn>
<apply><exp/>
<apply><divide/>
<apply><plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">100.0</cn>
</apply>
<cn cellml:units="voltage_units">25.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_na_late</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_na_late</ci>
<ci>y_na_late</ci>
</apply>
<ci>tau_y_na_late</ci>
</apply>
</apply>
</math>
</component>
<component name="i_na_late">
<variable name="i_na_late" units="current_units" public_interface="out"/>
<variable name="E_na" units="voltage_units"/>
<variable name="G_max_na_late" units="conductance_units" initial_value="2.0"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_na_late" units="dimensionless" private_interface="in"/>
<variable name="y_na_late" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_na</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_na_late</ci>
<apply>
<times/>
<ci>G_max_na_late</ci>
<ci>x_na_late</ci>
<ci>y_na_late</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_k1">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_k1" units="dimensionless" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq/>
<ci>x_k1</ci>
<apply><divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply> <plus/>
<cn cellml:units="voltage_units">92.0</cn>
<ci>Vm</ci>
</apply>
<cn cellml:units="voltage_units">10.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_k1">
<variable name="i_k1" units="current_units" public_interface="out"/>
<variable name="E_k" units="voltage_units"/>
<variable name="G_max_k1" units="conductance_units" initial_value="20.0"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_k1" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_k</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_k1</ci>
<apply>
<times/>
<ci>G_max_k1</ci>
<apply><power/>
<apply><divide/>
<ci>K_o</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
<cn cellml:units="dimensionless">0.8</cn>
</apply>
<ci>x_k1</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_k</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_kr">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_kr" units="dimensionless" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_kr</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="voltage_units">33.0</cn>
<ci>Vm</ci>
</apply>
<cn cellml:units="voltage_units">22.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="y_kr">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_kr" units="dimensionless"/>
<variable name="tau_y_kr" units="time_units"/>
<variable name="y_kr" units="dimensionless" initial_value="0.25" public_interface="out"/>
<variable name="ykrv1" units="rate_constants_units"/>
<variable name="ykrv2" units="rate_constants_units"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_kr</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">50.0</cn>
</apply>
<cn cellml:units="voltage_units">-7.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ykrv1</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="rate_constants_units">0.00138</cn>
<cn cellml:units="inverse_voltage_units">1</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">7</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="inverse_voltage_units">-0.123</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">7</cn>
</apply>
</apply>
<cn cellml:units="voltage_units">0.001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="rate_constants_units">0.00138</cn>
<cn cellml:units="dimensionless">0.123</cn>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>ykrv2</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="rate_constants_units">0.000061</cn>
<cn cellml:units="inverse_voltage_units">1</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">10</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="inverse_voltage_units">0.145</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">10</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">10</cn>
</apply>
</apply>
<cn cellml:units="voltage_units">0.001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="rate_constants_units">0.00061</cn>
<cn cellml:units="dimensionless">0.145</cn>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>tau_y_kr</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>ykrv1</ci>
<ci>ykrv2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_kr</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_kr</ci>
<ci>y_kr</ci>
</apply>
<ci>tau_y_kr</ci>
</apply>
</apply>
</math>
</component>
<component name="i_kr">
<variable name="i_kr" units="current_units" public_interface="out"/>
<variable name="E_k" units="voltage_units"/>
<variable name="G_max_kr" units="conductance_units" initial_value="1.5"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_kr" units="dimensionless" private_interface="in"/>
<variable name="y_kr" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_k</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_kr</ci>
<apply>
<times/>
<ci>G_max_kr</ci>
<apply><power/>
<apply><divide/>
<ci>K_o</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>x_kr</ci>
<ci>y_kr</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_k</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_ks">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_inf_ks" units="dimensionless" public_interface="out"/>
<variable name="tau_x_ks" units="time_units" public_interface="out"/>
<variable name="x_ks" units="dimensionless" initial_value="1.0" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_inf_ks</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">1.5</cn>
</apply>
<cn cellml:units="voltage_units">-16.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>tau_x_ks</ci>
<piecewise>
<piece>
<cn cellml:units="time_units">417.9462</cn>
<apply>
<lt/>
<apply>
<abs/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">30</cn>
</apply>
</apply>
<cn cellml:units="voltage_units">0.0145</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="time_units">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="inverse_voltage_units">0.0000719</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">30</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="inverse_voltage_units">-0.148</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="inverse_voltage_units">0.000131</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">30</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="inverse_voltage_units">0.0687</cn>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">30</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x_ks</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_inf_ks</ci>
<ci>x_ks</ci>
</apply>
<ci>tau_x_ks</ci>
</apply>
</apply>
</math>
</component>
<component name="y_ks">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_ks" units="dimensionless"/>
<variable name="tau_y_ks" units="time_units"/>
<variable name="y_ks" units="dimensionless" initial_value="0.0" public_interface="out"/>
<variable name="x_inf_ks" units="dimensionless" public_interface="in"/>
<variable name="tau_x_ks" units="time_units" public_interface="in"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_ks</ci>
<ci>x_inf_ks</ci>
</apply>
<apply>
<eq/>
<ci>tau_y_ks</ci>
<apply><times/>
<cn cellml:units="dimensionless">4</cn>
<ci>tau_x_ks</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_ks</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_ks</ci>
<ci>y_ks</ci>
</apply>
<ci>tau_y_ks</ci>
</apply>
</apply>
</math>
</component>
<component name="i_ks">
<variable name="i_ks" units="current_units" public_interface="out"/>
<variable name="E_k" units="voltage_units"/>
<variable name="G_max_ks" units="conductance_units" initial_value="3.0"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_ks" units="dimensionless" private_interface="in"/>
<variable name="y_ks" units="dimensionless" private_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_k</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ks</ci>
<apply>
<times/>
<ci>G_max_ks</ci>
<ci>x_ks</ci>
<ci>y_ks</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_k</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_naca">
<variable name="i_naca" units="current_units" public_interface="out"/>
<variable name="n_NaCa" units="dimensionless" initial_value="3" public_interface="out"/>
<variable name="g_NaCa" units="current_units" initial_value="0.001"/>
<variable name="d_NaCa" units="dimensionless" initial_value="0.001"/>
<variable name="gamma" units="dimensionless" initial_value="0.5"/>
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_naca</ci>
<apply><divide/>
<apply> <times/>
<cn cellml:units="dimensionless">512.009113204</cn>
<ci>g_NaCa</ci>
<apply> <minus/>
<apply><times/>
<apply><exp/>
<apply><divide/>
<apply><times/>
<ci>gamma</ci>
<apply><minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Vm</ci>
</apply>
<ci>RToF</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply><times/>
<ci>Cai</ci>
<apply><exp/>
<apply><divide/>
<apply><times/>
<apply><minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply><minus/>
<ci>n_NaCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Vm</ci>
</apply>
<ci>RToF</ci>
</apply>
</apply>
<apply><power/>
<ci>Nao</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
</apply>
</apply><!--end of numerator-->
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="millimolar_power_4">1</cn>
<apply>
<times/>
<ci>d_NaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>Cai</ci>
<apply>
<power/>
<ci>Nao</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<power/>
<ci>Nai</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cai</ci>
<cn cellml:units="millimolar">0.0069</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="x_nak">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="x_nak" units="dimensionless" private_interface="out" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_nak</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">80.0</cn>
</apply>
<cn cellml:units="voltage_units">-45.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="y_nak">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_nak" units="dimensionless" private_interface="out" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_nak</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">0.0</cn>
</apply>
<cn cellml:units="voltage_units">125.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_nak">
<variable name="i_nak" units="current_units" public_interface="out"/>
<variable name="g_nak" units="current_units" initial_value="442.2"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="x_nak" units="dimensionless" private_interface="in"/>
<variable name="y_nak" units="dimensionless" private_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_nak</ci>
<apply>
<times/>
<ci>g_nak</ci>
<ci>x_nak</ci>
<ci>y_nak</ci>
<apply><divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><power/>
<apply><divide/>
<cn cellml:units="millimolar">1.9</cn>
<ci>K_o</ci>
</apply>
<cn cellml:units="dimensionless">1.45</cn>
</apply>
</apply>
</apply>
<apply><divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><power/>
<apply><divide/>
<cn cellml:units="millimolar">31.98</cn>
<ci>Na_i</ci>
</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_kb">
<variable name="i_kb" units="current_units" public_interface="out"/>
<variable name="E_k" units="voltage_units"/>
<variable name="G_max_kb" units="conductance_units" initial_value="0.01"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in" />
<variable name="K_i" units="millimolar" public_interface="in" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_k</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_kb</ci>
<apply>
<times/>
<ci>G_max_kb</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_k</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_nab">
<variable name="i_nab" units="current_units" public_interface="out"/>
<variable name="E_na" units="voltage_units"/>
<variable name="G_max_nab" units="conductance_units" initial_value="0.01"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_na</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_nab</ci>
<apply>
<times/>
<ci>G_max_nab</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_cab">
<variable name="i_cab" units="current_units" public_interface="out"/>
<variable name="E_ca" units="voltage_units"/>
<variable name="G_max_cab" units="conductance_units" initial_value="0.0001"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="Ca_o" units="millimolar" public_interface="in"/>
<variable name="Ca_i_peripheral" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i_peripheral</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_cab</ci>
<apply>
<times/>
<ci>G_max_cab</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_pmca">
<variable name="i_pmca" units="current_units" public_interface="out"/>
<variable name="PMCA_max" units="current_units" initial_value="5.0"/>
<variable name="Ca_i_peripheral" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Kpmca" units="millimolar" initial_value="0.0001"/>
<variable name="Hpmca" units="dimensionless" initial_value="1.5"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_pmca</ci>
<apply>
<times/>
<ci>PMCA_max</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><power/>
<apply><divide/>
<ci>Kpmca</ci>
<ci>Ca_i_peripheral</ci>
</apply>
<ci>Hpmca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_f_k">
<variable name="i_f_k" units="current_units" public_interface="out"/>
<variable name="G_f_k" units="conductance_units" initial_value="0.188709677"/>
<variable name="E_k" units="voltage_units"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="y_gate_f_k" units="dimensionless" private_interface="in"/>
<variable name="K_o" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_k</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>K_o</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_k</ci>
<apply>
<times/>
<ci>G_f_k</ci>
<ci>y_gate_f_k</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_k</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_f_na">
<variable name="i_f_na" units="current_units" public_interface="out"/>
<variable name="G_f_na" units="conductance_units" initial_value="0.045290323"/>
<variable name="E_na" units="voltage_units"/>
<variable name="Vm" units="voltage_units" public_interface="in" private_interface="out"/>
<variable name="RToF" units="voltage_units" public_interface="in"/>
<variable name="y_gate_f_na" units="dimensionless" private_interface="in"/>
<variable name="Na_o" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="time" units="time_units" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_na</ci>
<apply>
<times/>
<ci>RToF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_na</ci>
<apply>
<times/>
<ci>G_f_na</ci>
<ci>y_gate_f_na</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="y_gate_f_k">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_f_gate" units="dimensionless"/>
<variable name="tau_y_f_gate" units="time_units"/>
<variable name="y_gate_f_k" units="dimensionless" initial_value="0.011099" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_f_gate</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">109.0</cn>
</apply>
<cn cellml:units="voltage_units">10.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>tau_y_f_gate</ci>
<apply><divide/>
<cn cellml:units="time_units">6000.0</cn>
<apply><plus/>
<apply><exp/>
<apply><times/>
<cn cellml:units="inverse_voltage_units">-1.0</cn>
<apply><plus/>
<cn cellml:units="voltage_units">2.9</cn>
<apply><times/>
<cn cellml:units="dimensionless">0.04</cn>
<ci>Vm</ci>
</apply>
</apply>
</apply>
</apply>
<apply><exp/>
<apply><times/>
<cn cellml:units="inverse_voltage_units">1.0</cn>
<apply><plus/>
<cn cellml:units="voltage_units">3.6</cn>
<apply><times/>
<cn cellml:units="dimensionless">0.11</cn>
<ci>Vm</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_gate_f_k</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_f_gate</ci>
<ci>y_gate_f_k</ci>
</apply>
<ci>tau_y_f_gate</ci>
</apply>
</apply>
</math>
</component>
<component name="y_gate_f_na">
<variable name="Vm" units="voltage_units" public_interface="in"/>
<variable name="y_inf_f_gate" units="dimensionless"/>
<variable name="tau_y_f_gate" units="time_units"/>
<variable name="y_gate_f_na" units="dimensionless" initial_value="0.011099" public_interface="out"/>
<variable name="time" units="time_units" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_inf_f_gate</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm</ci>
<cn cellml:units="voltage_units">109.0</cn>
</apply>
<cn cellml:units="voltage_units">10.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>tau_y_f_gate</ci>
<apply><divide/>
<cn cellml:units="time_units">6000.0</cn>
<apply><plus/>
<apply><exp/>
<apply><times/>
<cn cellml:units="inverse_voltage_units">-1.0</cn>
<apply><plus/>
<cn cellml:units="voltage_units">2.9</cn>
<apply><times/>
<cn cellml:units="dimensionless">0.04</cn>
<ci>Vm</ci>
</apply>
</apply>
</apply>
</apply>
<apply><exp/>
<apply><times/>
<cn cellml:units="inverse_voltage_units">1.0</cn>
<apply><plus/>
<cn cellml:units="voltage_units">3.6</cn>
<apply><times/>
<cn cellml:units="dimensionless">0.11</cn>
<ci>Vm</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_gate_f_na</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_inf_f_gate</ci>
<ci>y_gate_f_na</ci>
</apply>
<ci>tau_y_f_gate</ci>
</apply>
</apply>
</math>
</component>
<component name="i_rel_per">
<variable name="i_rel_per" units="current_units" public_interface="out"/>
<variable name="REL_max" units="current_per_millimolar_units" initial_value="2500.0"/>
<variable name="Ca_i_peripheral" units="millimolar" public_interface="in" />
<variable name="Ca_sr" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Krel" units="millimolar" initial_value="0.001"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_rel_per</ci>
<apply>
<times/>
<ci>REL_max</ci>
<apply>
<divide/>
<ci>Ca_sr</ci>
<apply><plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><power/>
<apply><divide/>
<ci>Krel</ci>
<ci>Ca_i_peripheral</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_serca_per">
<variable name="i_serca_per" units="current_units" public_interface="out" />
<variable name="SERCA_max" units="current_units" initial_value="120.0"/>
<variable name="Ca_i_peripheral" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_sr" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Kmf" units="millimolar" initial_value="0.000246"/>
<variable name="Kmr" units="millimolar" initial_value="1.7"/>
<variable name="H" units="dimensionless" initial_value="1.6"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_serca_per</ci>
<apply>
<times/>
<ci>SERCA_max</ci>
<apply>
<divide/>
<apply><minus/>
<apply><power/>
<apply><divide/>
<ci>Ca_i_peripheral</ci>
<ci>Kmf</ci>
</apply>
<ci>H</ci>
</apply>
<apply><power/>
<apply><divide/>
<ci>Ca_sr</ci>
<ci>Kmr</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
<apply><plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><power/>
<apply><divide/>
<ci>Ca_i_peripheral</ci>
<ci>Kmf</ci>
</apply>
<ci>H</ci>
</apply>
<apply><power/>
<apply><divide/>
<ci>Ca_sr</ci>
<ci>Kmr</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_serca_bulk">
<variable name="i_serca_bulk" units="current_units" public_interface="out" />
<variable name="SERCA_max" units="current_units" initial_value="120.0"/>
<variable name="Ca_i_bulk" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_sr" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Kmf" units="millimolar" initial_value="0.000246"/>
<variable name="Kmr" units="millimolar" initial_value="1.7"/>
<variable name="H" units="dimensionless" initial_value="1.6"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_serca_bulk</ci>
<apply>
<times/>
<ci>SERCA_max</ci>
<apply>
<divide/>
<apply><minus/>
<apply><power/>
<apply><divide/>
<ci>Ca_i_bulk</ci>
<ci>Kmf</ci>
</apply>
<ci>H</ci>
</apply>
<apply><power/>
<apply><divide/>
<ci>Ca_sr</ci>
<ci>Kmr</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
<apply><plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply><power/>
<apply><divide/>
<ci>Ca_i_bulk</ci>
<ci>Kmf</ci>
</apply>
<ci>H</ci>
</apply>
<apply><power/>
<apply><divide/>
<ci>Ca_sr</ci>
<ci>Kmr</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_leak">
<variable name="i_leak" units="current_units" public_interface="out"/>
<variable name="LEAK_max" units="current_per_millimolar_units" initial_value="10.0"/>
<variable name="Ca_i_bulk" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_sr" units="millimolar" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_leak</ci>
<apply>
<times/>
<ci>LEAK_max</ci>
<apply><minus/>
<ci>Ca_sr</ci>
<ci>Ca_i_bulk</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="i_diff">
<variable name="i_diff" units="current_units" public_interface="out"/>
<variable name="DIFF_max" units="current_per_millimolar_units" initial_value="5000.0"/>
<variable name="Ca_i_bulk" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_i_peripheral" units="millimolar" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_diff</ci>
<apply>
<times/>
<ci>DIFF_max</ci>
<apply><minus/>
<ci>Ca_i_peripheral</ci>
<ci>Ca_i_bulk</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="x_Ttype" component_2="i_cat"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_Ttype" variable_2="x_Ttype"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_Ttype" component_2="i_cat"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_Ttype" variable_2="y_Ttype"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_cat" component_2="membrane"/>
<map_variables variable_1="Ca_i_peripheral" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_cat" variable_2="i_cat"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="x_Ltype" component_2="i_cal"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_Ltype" variable_2="x_Ltype"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_Ltype" component_2="i_cal"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_Ltype" variable_2="y_Ltype"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_ca_Ltype" component_2="i_cal"/>
<map_variables variable_1="y_ca_Ltype" variable_2="y_ca_Ltype"/>
<map_variables variable_1="Ca_i_peripheral" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_cal" component_2="membrane"/>
<map_variables variable_1="Ca_i_peripheral" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_cal" variable_2="i_cal"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="x_to_fast" component_2="i_to_fast"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_to_fast" variable_2="x_to_fast"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_to_fast" component_2="i_to_fast"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_to_fast" variable_2="y_to_fast"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_to_fast" component_2="membrane"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_to_fast" variable_2="i_to_fast"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="x_to_sustained" component_2="i_to_sustained"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_to_sustained" variable_2="x_to_sustained"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_to_sustained" component_2="membrane"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_to_sustained" variable_2="i_to_sustained"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="x_na_fast" component_2="i_na_fast"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_na_fast" variable_2="x_na_fast"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_na_fast" component_2="i_na_fast"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_na_fast" variable_2="y_na_fast"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_na_fast" component_2="membrane"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_na_fast" variable_2="i_na_fast"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="x_na_late" component_2="i_na_late"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_na_late" variable_2="x_na_late"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_na_late" component_2="i_na_late"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_na_late" variable_2="y_na_late"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_na_late" component_2="membrane"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_na_late" variable_2="i_na_late"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="x_k1" component_2="i_k1"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_k1" variable_2="x_k1"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_k1" component_2="membrane"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_k1" variable_2="i_k1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="x_kr" component_2="i_kr"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_kr" variable_2="x_kr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_kr" component_2="i_kr"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_kr" variable_2="y_kr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_kr" component_2="membrane"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_kr" variable_2="i_kr"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="x_ks" component_2="y_ks"/>
<map_variables variable_1="x_inf_ks" variable_2="x_inf_ks"/>
<map_variables variable_1="tau_x_ks" variable_2="tau_x_ks"/>
</connection>
<connection>
<map_components component_1="x_ks" component_2="i_ks"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_ks" variable_2="x_ks"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_ks" component_2="i_ks"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_ks" variable_2="y_ks"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_ks" component_2="membrane"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_ks" variable_2="i_ks"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="i_naca" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_naca" variable_2="i_naca"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Cao" variable_2="Ca_o"/>
<map_variables variable_1="Cai" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="Nao" variable_2="Na_o"/>
<map_variables variable_1="Nai" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="i_nak" component_2="y_nak"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_nak" variable_2="y_nak"/>
</connection>
<connection>
<map_components component_1="i_nak" component_2="x_nak"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="x_nak" variable_2="x_nak"/>
</connection>
<connection>
<map_components component_1="i_nak" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_nak" variable_2="i_nak"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="i_kb" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="i_kb" variable_2="i_kb"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="i_nab" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="i_nab" variable_2="i_nab"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="i_cab" component_2="membrane"/>
<map_variables variable_1="Ca_i_peripheral" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_cab" variable_2="i_cab"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="i_pmca" component_2="membrane"/>
<map_variables variable_1="Ca_i_peripheral" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="i_pmca" variable_2="i_pmca"/>
</connection>
<connection>
<map_components component_1="i_f_na" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="i_f_na" variable_2="i_f_na"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="i_f_k" component_2="membrane"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="i_f_k" variable_2="i_f_k"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="y_gate_f_k" component_2="i_f_k"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_gate_f_k" variable_2="y_gate_f_k"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="y_gate_f_na" component_2="i_f_na"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="y_gate_f_na" variable_2="y_gate_f_na"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="i_rel_per" component_2="membrane"/>
<map_variables variable_1="Ca_i_peripheral" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="Ca_sr" variable_2="Ca_sr"/>
<map_variables variable_1="i_rel_per" variable_2="i_rel_per"/>
</connection>
<connection>
<map_components component_1="i_serca_per" component_2="membrane"/>
<map_variables variable_1="Ca_i_peripheral" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="Ca_sr" variable_2="Ca_sr"/>
<map_variables variable_1="i_serca_per" variable_2="i_serca_per"/>
</connection>
<connection>
<map_components component_1="i_serca_bulk" component_2="membrane"/>
<map_variables variable_1="Ca_i_bulk" variable_2="Ca_i_bulk"/>
<map_variables variable_1="Ca_sr" variable_2="Ca_sr"/>
<map_variables variable_1="i_serca_bulk" variable_2="i_serca_bulk"/>
</connection>
<connection>
<map_components component_1="i_leak" component_2="membrane"/>
<map_variables variable_1="Ca_i_bulk" variable_2="Ca_i_bulk"/>
<map_variables variable_1="Ca_sr" variable_2="Ca_sr"/>
<map_variables variable_1="i_leak" variable_2="i_leak"/>
</connection>
<connection>
<map_components component_1="i_diff" component_2="membrane"/>
<map_variables variable_1="Ca_i_bulk" variable_2="Ca_i_bulk"/>
<map_variables variable_1="Ca_i_peripheral" variable_2="Ca_i_peripheral"/>
<map_variables variable_1="i_diff" variable_2="i_diff"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Environment"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="RToF" variable_2="RToF"/>
<map_variables variable_1="FoRT" variable_2="FoRT"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="Time" component_2="membrane"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="membrane">
<component_ref component="i_cat">
<component_ref component="x_Ttype"/>
<component_ref component="y_Ttype"/>
</component_ref>
<component_ref component="i_cal">
<component_ref component="x_Ltype"/>
<component_ref component="y_Ltype"/>
<component_ref component="y_ca_Ltype"/>
</component_ref>
<component_ref component="i_k1">
<component_ref component="x_k1"/>
</component_ref>
<component_ref component="i_to_fast">
<component_ref component="x_to_fast"/>
<component_ref component="y_to_fast"/>
</component_ref>
<component_ref component="i_to_sustained">
<component_ref component="x_to_sustained"/>
</component_ref>
<component_ref component="i_kr">
<component_ref component="x_kr"/>
<component_ref component="y_kr"/>
</component_ref>
<component_ref component="i_ks">
<component_ref component="x_ks"/>
<component_ref component="y_ks"/>
</component_ref>
<component_ref component="i_kb">
</component_ref>
<component_ref component="i_nak">
<component_ref component="y_nak"/>
<component_ref component="x_nak"/>
</component_ref>
<component_ref component="i_na_fast">
<component_ref component="x_na_fast"/>
<component_ref component="y_na_fast"/>
</component_ref>
<component_ref component="i_na_late">
<component_ref component="x_na_late"/>
<component_ref component="y_na_late"/>
</component_ref>
<component_ref component="i_f_na">
<component_ref component="y_gate_f_na"/>
</component_ref>
<component_ref component="i_f_k">
<component_ref component="y_gate_f_k"/>
</component_ref>
<component_ref component="i_naca"/>
<component_ref component="i_cab"/>
<component_ref component="i_nab"/>
<component_ref component="i_pmca"/>
<component_ref component="i_leak"/>
<component_ref component="i_diff"/>
<component_ref component="i_rel_per"/>
<component_ref component="i_serca_per"/>
<component_ref component="i_serca_bulk"/>
</component_ref>
</group>
</model>
