Signal Transduction

Asthagiri, Lauffenburger, 2001: A Compuational Study of Feedback Effects on Signal Dynamics in a Mitogen-Activated Protein Kinase (MAPK) Pathway Model
Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2006: Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores
Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2008: Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis (Model II)
Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2008: Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis (Model III)
Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2008: Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis (Model II)
Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2008: Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis (Model III)
Bertram, Arnot, Zamponi, 2002: Role for G protein G-beta-gamma isoform specificity in synaptic signal processing (Pre-Synaptic Cell)
Bertram, Arnot, Zamponi, 2002: Role for G protein G-beta-gamma isoform specificity in synaptic signal processing (Post-Synaptic Cell)
Bertram, Smolen, Sherman, Mears, Atwater, Martin, Soria, 1995: A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells
Bhalla, Iyengar, 1999: Complete network of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: Ca-IP3 component of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: EGFR pathway component of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: MAPK pathway component of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: Conversion of PIP to IP3 and DAG component of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: PKC pathway component of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: PLA2 pathway component of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: PLC-gamma pathway component of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: RAS pathway component of the Bhalla-Iyengar model
Bhalla, Iyengar, 1999: phospholipase C (PLC) pathway component of the Bhalla-Iyengar model
Bornheimer, Maurya, Farquhar, Subramaniam, 2004: Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction
Brightman, Fell, 2000: Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells.
Chen, Popel, 2006: Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells
Chen, Popel, 2007: Vascular and perivascular nitric oxide release and transport (Fe3 = 0.6 micromolar)
Chen, Popel, 2007: Vascular and perivascular nitric oxide release and transport (Fe3 = 0.9 micromolar)
Cooling, Hunter, Crampin, 2007: Modeling hypertrophic IP3 transients in the cardiac myocyte
Cooling, Hunter, Crampin, 2008: Modeling Biological Modularity with CellML
Cooling, Hunter, Crampin, 2009: Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes (Shen-derived calcium protocol)
Cooling, Hunter, Crampin, 2009: Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes (Dual Calcium Protocol)
Cooling, Hunter, Crampin, 2009: Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes (Tomida-derived calcium protocol)
Cui, Kaandorp, 2008: Simulating Complex Calcium-Calcineurin Signaling Network
Dawson, Lea, Irvine, 2003: Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores
De Young, Keizer, 1992: A single-pool inositol 1,4,5-triphosphate-receptor-based model for agonist-stimulated oscillations in Ca 2+ concentration
Demir, Clark, Giles, 1999: Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart: a unifying model
Dougherty, Wright, Yew, 2005: Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons
Fall, Keizer, 2001: Mitochondrial Modulation of Intracellular Ca2+ Signalling
Fallon, Lauffenburger, 2000: Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response
Farhy, Bowers, Veldhuis, 2007: Female-specific model and GHRH alone is being injected
Farhy, Bowers, Veldhuis, 2007: Male-specific model and GHRH alone is being injected
Farhy, Bowers, Veldhuis, 2007: Female-specific model and GHRH alone is being injected
Farhy, Bowers, Veldhuis, 2007: Male-specific model and GHRH alone is being injected
Fujita, Toyoshima, Uda, Ozaki, Kubota, Kuroda, 2010: Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics: EGF-dependent Akt pathway model
Fujita, Toyoshima, Uda, Ozaki, Kubota, Kuroda, 2010: Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics: NGF-dependent Akt pathway model
Fujita, Toyoshima, Uda, Ozaki, Kubota, Kuroda, 2010: Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics: EGFR-inhibited Akt pathway model
Goldbeter, Gonze, Pourquie, 2007: Sharp Developmental Thresholds Defined Through Bistability By Antagonistic Gradients of Retinoic Acid and FGF Signaling
Goldbeter, Pourquie, 2008: Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways: coupled Notch, Wnt and FGF signalling pathways
Goldbeter, Pourquie, 2008: Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways: uncoupled Notch, Wnt and FGF signalling pathways
Grandi, Pasqualini, Bers, 2009: A novel computational model of the human ventricular action potential and Ca transient
Gupta, Maurya, Stephens, Dennis, Subramaniam, 2009: An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis
Gupta, Maurya, Stephens, Dennis, Subramaniam, 2009: An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis
Hatakeyama, Shirouzu, Yokoyama, Konagaya, Kimura, Naka, Kawasaki, Yumoto, Ichikawa, Kim, Saito, Saeki, 2003: A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling
Hornberg, Binder, Bruggeman, Schoeberl, Heinrich, Westerhoff, 2005: Control of MAPK signalling: from complexity to what really matters
Huang, Ferrell, 1996: Ultrasensitivity in the mitogen-activated protein kinase cascade
Iancu, Jones, Harvey, 2007: Compartmentation of cAMP signaling in cardiac myocytes: a computational study
Iancu, Jones, Harvey, 2007: Compartmentation of cAMP signaling in cardiac myocytes: a computational study
Karagiannis, Popel, 2004: A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2
Karagiannis, Popel, 2006: Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model
Kholodenko, Demin, Moehren, Hoek, 1999: Quantification of short term signalling by the epidermal growth
Kholodenko, Demin, Moehren, Hoek, 1999: Quantification of short term signalling by the epidermal growth
Kirschner, Panetta, 1998: Modeling immunotherapy of the tumor-immune interaction
LeBeau, Yule, Groblewski, Sneyd, 1999: Agonist-dependent Phosphorylation of the Inositol 1,4,5-Triphosphate Receptor
Leloup, Goldbeter, 2003: Toward a detailed computational model for the mammalian circadian clock
Leloup, Goldbeter, 2004: Modeling the mammalian circadian clock: sensitivity analysis and multiplicity of oscillatory mechanisms
Leloup, Gonze, Goldbeter, 1999: Limit Cycle Model for Circadian Rhythms in Drosophila and Neurospora (Drosophila model)
Leloup, Gonze, Goldbeter, 1999: Limit Cycle Model for Circadian Rhythms in Drosophila and Neurospora (Neurospora model)
Maly, Wiley, Lauffenburger, 2004: Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis
Marwan, 2003: Theory of Time-Resolved Somatic Complementation and Its Use to Explore the Sporulation Control Network in Physarum polycephalum
Maurya, Bornheimer, Venkatasubramanian, Subramaniam, 2005: Reduced-order modelling of biochemical networks: application to the GTPase-cycle signalling module
Muller, Obeyesekere, Mills, Ram, 2008: Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R
Proctor, Soti, Boys, Gillespie, Shanley, Wilkinson, Kirkwood, 2005: Modelling the actions of chaperones and their role in ageing.
Proctor, Tsiringotis, Gray, 2007: An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline
Rangamani, Sirovich, 2007: Survival and apoptotic pathways initiated by TNF-alpha: modeling and predictions
Reidl, Borowski, Sensse, Starke, Zapotocky, Eiswirth, 2006: Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia
Riccobene, Omann, Linderman, 1999: Modeling Activation and Desensitisation of G-Protein Coupled Receptors Provides Insight into Ligand Efficacy
Sachse, Glanzel, Seemann, 2003: Modeling of Protein Interactions Involved in Cardiac Tension Development
Saftenku, Williams, Sitsapesan, 2001: Markovian Models of Low and High Activity Levals of Cardiac Ryanodine Receptors (Low Model)
Sarkar, Lauffenburger, 2003: Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo
Saucerman, Brunton, Michailova, McCulloch, 2003: Modeling beta-adrenergic control of cardiac myocyte contractility in silico
Saucerman, McCulloch, 2004: Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation
Schoeberl, Eichler-Jonsson, Gilles, Muller, 2002: Computational Modeling of the Dynamics of the MAP Kinase Cascade Activated by Surface and Internalized EGF Receptors.
Schuster, Beny, Meister, 2003: Modelling the electrophysiological endothelial cell response to bradykinin
Sedaghat, Sherman, Quon, 2002: A mathematical model of metabolic insulin signaling pathways (without feedback)
Sedaghat, Sherman, Quon, 2002: A mathematical model of metabolic insulin signaling pathways (with feedback)
Shorten, Robson, McKinnon, Wall, 2000: CRH-induced Electrical Activity and Calcium Signalling in Pituitary Corticotrophs
Spiro, Parkinson, Othmer, 1997: A model of excitation and adaptation in bacterial chemotaxis
St Hilaire, Gronfier, Zeitzer, Klerman, 2007: A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker
Starbuck, Wiley, Lauffenburger, 1990: Epidermal Growth Factor Binding and Trafficking Dynamics in Fibroblasts: Relationship to Cell Proliferation
Tabak, Mascagni, Bertram, 2010: Mechanism for the Universal Pattern of Activity in Developing Neuronal Networks
Thomsen, Neubig, 1989: Rapid kinetics of alpha 2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step
Tolic, Mosekilde, Sturis, 2000: Modelling the Insulin-Glucose Feedback System: The Significance of Pulsatile Insulin Secretion
Topp, Promislow, de Vries, Miura, Finegood, 2000: A Model of Beta-Cell Mass, Insulin, and Glucose Kinetics: Paythways to Diabetes
Ueda, Hagiwara, Kitano, 2001: Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
Vempati, Karagiannis, Popel, 2007: A Biochemical Model of Matrix Metalloproteinase 9 Activation and Inhibition
Vilar, Jansen, Sander, 2006: Signal processing in the TGF-beta superfamily ligand-receptor network (Standard Form)
Vilar, Jansen, Sander, 2006: Signal processing in the TGF-beta superfamily ligand-receptor network (Reaction Form)
Vilar, Kueh, Barkai, Leibler, 2002: Mechanisms of noise-resistance in genetic oscillators
Wanant, Quon, 2000: Insulin receptor binding kinetics: modeling and simulation studies (Divalent Receptor Model)
Wanant, Quon, 2000: Insulin receptor binding kinetics: modeling and simulation studies (Receptor Aggregation Model)
Wang, Cirit, Haugh, 2009: PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk
Warashina, Ogura, 2004: Modeling of simulation-secretion coupling in a chromaffin cell
Warren, Tawhai, Crampin, 2010: Mathematical modelling of calcium wave propagation in mammalian airway epithelium: evidence for regenerative ATP release
Winograd, Destexhe, Sanchez-Vives, 2008: Hyperpolarization-activated graded persistent activity in the prefrontal cortex
Wolf, Passarge, Somsen, Snoep, Heinrich, Westerhoff, 2000: Transduction of Intracellular and Intercellular Dynamics in Yeast Glycolytic Oscillations
Yang, Clark, Bryan, Robertson, 2003: The myogenic response in isolated rat cerebrovascular arteries: smooth muscle cell model