Lenbury, Pacheenburawana, 1991

Model Status

This CellML model runs in OpenCell and COR, and the units are consistent. The model is an accurate representation of the published model (equations 1a-1c), and runs to recreate the published results (figure 4). Parameter values were taken from the legend of figure 4.

Model Structure

ABSTRACT: A system of three non-linear differential equations with exponential feedback terms is proposed to model the self-regulating cortisol secretion system and explain the fluctuation patterns observed in clinical data. It is shown that the model exhibits bifurcation and chaos patterns for a certain range of parametric values. This helps us to explain clinical observations and characterize different dynamic behaviors of the self-regulative system.

The original paper reference is cited below:

Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man, Yongwimon Lenbury and Pariwatana Pacheenburawana, 1991, BioSystems , 26, 117-125. PubMed ID: 1668715

Schematic diagram of the self-regulatory system for corticol secretion. CRH represents corticotropin-releasing hormone, ACTH is adrenocorticotropic hormone, and F represents cortisol. The red lines represent positive feedback pathways, while the blue lines represent negative feedback loops.