You are here: Home / Exposures / Haugh, 2004 / Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists (Basic Model)

Model Mathematics

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Component: environment

Component: C

\frac{d}{d time} (C) = kf1 L R + k_x2 D - ((kr1 + kx2 R + kt) C)

Component: D

\frac{d}{d time} (D) = kx2 R C - ((k_x2 + k_x1 + ke) D)

Component: R

\frac{d}{d time} (R) = Vs + kr1 C + (k_x2 + 2.0 k_x1) D + krec Ri - ((kf1 L + kx2 C + kt) R)

Component: Ri

\frac{d}{d time} (Ri) = kt (R + C) - ((krec + kdeg) Ri)

Component: signal

signal = \frac{\frac{2.0 D}{R_initial}}{kappaE + \frac{2.0 D}{R_initial}}

Component: model_parameters

kr1 = KD kf1 k_x1 = 0.01 kr1

Source: Derived from workspace Haugh, 2004 at changeset 6348326c2c7e.

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License: This work is licensed under a Creative Commons Attribution 3.0 Unported License.

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