Model Mathematics

Component: environment

Component: V1

V_1=V_max1GEFt

Component: V2

V_2=StrV_max2GEFt

Component: V3

V_3=k_c3PKAtGAPt

Component: V4

V_4=V_max4GAPt

Component: V5

V_5=k_gefGEFtRASt

Component: V6

V_6=k_gapGAPtRASt

Component: V7

V_7=k_c7PKAtPDEt

Component: V8

V_8=V_max8PDEt

Component: VPKAact

V_PKAact=aR2C2cAMP2-rCR2cAMP2PKAt21

Component: holoenzyme_R_cAMP

R2cAMP2=1-R2C2

Component: C_subunit

C=21-R2C2

Component: active_GEF

ddtimeGEFa=V_11-GEFaK_1+1-GEFa-V_2GEFaK_2+GEFa

Component: active_GAP

ddtimeGAPa=V_3C1-GAPaK_3+1-GAPa-V_4GAPaK_4+GAPa

Component: RAS_to_GTP

ddtimeRGTP=V_5GEFa1-RGTPK_5+1-RGTP-V_6GAPaRGTPK_6+RGTP

Component: adenylate_cyclase

ddtimeCYCLa=k_aRGTPRASt1-CYCLa-k_iCYCLa

Component: active_PDE

ddtimePDEa=V_7C1-PDEaK_7+1-PDEa-V_8PDEaK_8+PDEa

Component: cyclic_AMP

ddtimecAMP=k_sCYCLaCYCLt-k_dPDEtPDEacAMPK_md+cAMP-2V_PKAactPKAt

Component: holoenzyme_R_C

ddtimeR2C2=-aR2C2cAMP2+rC2R2cAMP2PKAt21

Component: V9

V_9=k_c9PKAtMSNt

Component: V10

V_10=StrV_max10MSNt

Component: V11

V_11=k_c11PKAtMSNt

Component: V12

V_12=StrV_max12MSNt

Component: cytosol

ddtimeMC=-k_t1MC+k_t2MN-V_11CMCK_11+MC+V_12MCPK_12+MCP

Component: nucleus

ddtimeMN=k_t1MC-k_t2MN-V_9CMNK_9+MN+V_10MNPK_10+MNP

Component: nucleus_phos

ddtimeMNP=V_9CMNK_9+MN-V_10MNPK_10+MNP+k_t3MCP-k_t4MNP

Component: cytosol_phos

ddtimeMCP=-k_t3MCP+k_t4MNP+V_11CMCK_11+MC-V_12MCPK_12+MCP

Component: Mcyto

M_cyto=MC+MCP

Component: Mnucl

M_nucl=MN+MNP