C C There are a total of 54 entries in the algebraic variable array. C There are a total of 26 entries in each of the rate and state variable arrays. C There are a total of 71 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is V in component membrane (millivolt). C CONSTS(1) is R in component membrane (millijoule_per_mole_kelvin). C CONSTS(2) is T in component membrane (kelvin). C CONSTS(3) is F in component membrane (coulomb_per_mole). C CONSTS(4) is Cm in component membrane (microF). C ALGBRC(27) is i_Na in component sodium_current (nanoA). C ALGBRC(28) is i_Ca_L in component L_type_Ca_channel (nanoA). C ALGBRC(30) is i_t in component Ca_independent_transient_outward_K_current (nanoA). C ALGBRC(31) is i_ss in component steady_state_outward_K_current (nanoA). C ALGBRC(35) is i_f in component hyperpolarisation_activated_current (nanoA). C ALGBRC(32) is i_K1 in component inward_rectifier (nanoA). C ALGBRC(39) is i_B in component background_currents (nanoA). C ALGBRC(40) is i_NaK in component sodium_potassium_pump (nanoA). C ALGBRC(42) is i_NaCa in component Na_Ca_ion_exchanger_current (nanoA). C ALGBRC(41) is i_Ca_P in component sarcolemmal_calcium_pump_current (nanoA). C ALGBRC(14) is i_Stim in component membrane (nanoA). C CONSTS(5) is stim_period in component membrane (second). C CONSTS(6) is stim_duration in component membrane (second). C CONSTS(7) is stim_amplitude in component membrane (nanoA). C ALGBRC(26) is E_Na in component sodium_current (millivolt). C CONSTS(8) is g_Na in component sodium_current (microS). C CONSTS(67) is g_Na_endo in component sodium_current (microS). C STATES(2) is Na_i in component intracellular_ion_concentrations (millimolar). C CONSTS(9) is Na_o in component standard_ionic_concentrations (millimolar). C STATES(3) is m in component sodium_current_m_gate (dimensionless). C STATES(4) is h in component sodium_current_h_gate (dimensionless). C STATES(5) is j in component sodium_current_j_gate (dimensionless). C ALGBRC(1) is m_infinity in component sodium_current_m_gate (dimensionless). C ALGBRC(15) is tau_m in component sodium_current_m_gate (second). C ALGBRC(2) is h_infinity in component sodium_current_h_gate (dimensionless). C ALGBRC(16) is tau_h in component sodium_current_h_gate (second). C ALGBRC(3) is j_infinity in component sodium_current_j_gate (dimensionless). C ALGBRC(17) is tau_j in component sodium_current_j_gate (second). C CONSTS(10) is g_Ca_L in component L_type_Ca_channel (microS). C CONSTS(11) is E_Ca_L in component L_type_Ca_channel (millivolt). C STATES(6) is Ca_ss in component intracellular_ion_concentrations (millimolar). C STATES(7) is d in component L_type_Ca_channel_d_gate (dimensionless). C STATES(8) is f_11 in component L_type_Ca_channel_f_11_gate (dimensionless). C STATES(9) is f_12 in component L_type_Ca_channel_f_12_gate (dimensionless). C STATES(10) is Ca_inact in component L_type_Ca_channel_Ca_inact_gate (dimensionless). C ALGBRC(4) is d_infinity in component L_type_Ca_channel_d_gate (dimensionless). C ALGBRC(18) is tau_d in component L_type_Ca_channel_d_gate (second). C ALGBRC(5) is f_11_infinity in component L_type_Ca_channel_f_11_gate (dimensionless). C ALGBRC(19) is tau_f_11 in component L_type_Ca_channel_f_11_gate (second). C ALGBRC(6) is f_12_infinity in component L_type_Ca_channel_f_12_gate (dimensionless). C ALGBRC(20) is tau_f_12 in component L_type_Ca_channel_f_12_gate (second). C CONSTS(12) is tau_Ca_inact in component L_type_Ca_channel_Ca_inact_gate (second). C ALGBRC(7) is Ca_inact_infinity in component L_type_Ca_channel_Ca_inact_gate (dimensionless). C ALGBRC(29) is E_K in component Ca_independent_transient_outward_K_current (millivolt). C CONSTS(13) is g_t in component Ca_independent_transient_outward_K_current (microS). C CONSTS(68) is g_t_endo in component Ca_independent_transient_outward_K_current (microS). C CONSTS(14) is a in component Ca_independent_transient_outward_K_current (dimensionless). C CONSTS(15) is b in component Ca_independent_transient_outward_K_current (dimensionless). C CONSTS(16) is K_o in component standard_ionic_concentrations (millimolar). C STATES(11) is K_i in component intracellular_ion_concentrations (millimolar). C STATES(12) is r in component Ca_independent_transient_outward_K_current_r_gate (dimensionless). C STATES(13) is s in component Ca_independent_transient_outward_K_current_s_gate (dimensionless). C STATES(14) is s_slow in component Ca_independent_transient_outward_K_current_s_slow_gate (dimensionless). C ALGBRC(21) is tau_r in component Ca_independent_transient_outward_K_current_r_gate (second). C ALGBRC(8) is r_infinity in component Ca_independent_transient_outward_K_current_r_gate (dimensionless). C ALGBRC(22) is tau_s in component Ca_independent_transient_outward_K_current_s_gate (second). C ALGBRC(9) is s_infinity in component Ca_independent_transient_outward_K_current_s_gate (dimensionless). C ALGBRC(23) is tau_s_slow in component Ca_independent_transient_outward_K_current_s_slow_gate (second). C ALGBRC(10) is s_slow_infinity in component Ca_independent_transient_outward_K_current_s_slow_gate (dimensionless). C CONSTS(17) is g_ss in component steady_state_outward_K_current (microS). C STATES(15) is r_ss in component steady_state_outward_K_current_r_ss_gate (dimensionless). C STATES(16) is s_ss in component steady_state_outward_K_current_s_ss_gate (dimensionless). C ALGBRC(24) is tau_r_ss in component steady_state_outward_K_current_r_ss_gate (second). C ALGBRC(11) is r_ss_infinity in component steady_state_outward_K_current_r_ss_gate (dimensionless). C CONSTS(69) is tau_s_ss in component steady_state_outward_K_current_s_ss_gate (second). C ALGBRC(12) is s_ss_infinity in component steady_state_outward_K_current_s_ss_gate (dimensionless). C CONSTS(18) is g_K1 in component inward_rectifier (microS). C ALGBRC(33) is i_f_Na in component hyperpolarisation_activated_current (nanoA). C ALGBRC(34) is i_f_K in component hyperpolarisation_activated_current (nanoA). C CONSTS(19) is g_f in component hyperpolarisation_activated_current (microS). C CONSTS(20) is f_Na in component hyperpolarisation_activated_current (dimensionless). C CONSTS(70) is f_K in component hyperpolarisation_activated_current (dimensionless). C STATES(17) is y in component hyperpolarisation_activated_current_y_gate (dimensionless). C ALGBRC(25) is tau_y in component hyperpolarisation_activated_current_y_gate (second). C ALGBRC(13) is y_infinity in component hyperpolarisation_activated_current_y_gate (dimensionless). C ALGBRC(36) is i_B_Na in component background_currents (nanoA). C ALGBRC(37) is i_B_Ca in component background_currents (nanoA). C ALGBRC(38) is i_B_K in component background_currents (nanoA). C CONSTS(21) is g_B_Na in component background_currents (microS). C CONSTS(22) is g_B_Ca in component background_currents (microS). C CONSTS(23) is g_B_K in component background_currents (microS). C CONSTS(24) is E_Ca in component background_currents (millivolt). C CONSTS(25) is Ca_o in component standard_ionic_concentrations (millimolar). C STATES(18) is Ca_i in component intracellular_ion_concentrations (millimolar). C CONSTS(26) is i_NaK_max in component sodium_potassium_pump (nanoA). C CONSTS(27) is K_m_K in component sodium_potassium_pump (millimolar). C CONSTS(28) is K_m_Na in component sodium_potassium_pump (millimolar). C CONSTS(71) is sigma in component sodium_potassium_pump (dimensionless). C CONSTS(29) is i_Ca_P_max in component sarcolemmal_calcium_pump_current (nanoA). C CONSTS(30) is K_NaCa in component Na_Ca_ion_exchanger_current (millimolar_4). C CONSTS(31) is d_NaCa in component Na_Ca_ion_exchanger_current (millimolar_4). C CONSTS(32) is gamma_NaCa in component Na_Ca_ion_exchanger_current (dimensionless). C ALGBRC(43) is J_rel in component SR_Ca_release_channel (millimolar_per_second). C CONSTS(33) is v1 in component SR_Ca_release_channel (per_second). C CONSTS(34) is k_a_plus in component SR_Ca_release_channel (millimolar4_per_second). C CONSTS(35) is k_a_minus in component SR_Ca_release_channel (per_second). C CONSTS(36) is k_b_plus in component SR_Ca_release_channel (millimolar3_per_second). C CONSTS(37) is k_b_minus in component SR_Ca_release_channel (per_second). C CONSTS(38) is k_c_plus in component SR_Ca_release_channel (per_second). C CONSTS(39) is k_c_minus in component SR_Ca_release_channel (per_second). C STATES(19) is P_O1 in component SR_Ca_release_channel (dimensionless). C STATES(20) is P_O2 in component SR_Ca_release_channel (dimensionless). C STATES(21) is P_C1 in component SR_Ca_release_channel (dimensionless). C STATES(22) is P_C2 in component SR_Ca_release_channel (dimensionless). C CONSTS(40) is n in component SR_Ca_release_channel (dimensionless). C CONSTS(41) is m in component SR_Ca_release_channel (dimensionless). C STATES(23) is Ca_JSR in component intracellular_ion_concentrations (millimolar). C ALGBRC(46) is J_up in component SERCA2a_pump (millimolar_per_second). C CONSTS(42) is K_fb in component SERCA2a_pump (millimolar). C CONSTS(43) is K_rb in component SERCA2a_pump (millimolar). C ALGBRC(44) is fb in component SERCA2a_pump (dimensionless). C ALGBRC(45) is rb in component SERCA2a_pump (dimensionless). C CONSTS(44) is Vmaxf in component SERCA2a_pump (millimolar_per_second). C CONSTS(45) is Vmaxr in component SERCA2a_pump (millimolar_per_second). C CONSTS(46) is K_SR in component SERCA2a_pump (dimensionless). C CONSTS(47) is N_fb in component SERCA2a_pump (dimensionless). C CONSTS(48) is N_rb in component SERCA2a_pump (dimensionless). C STATES(24) is Ca_NSR in component intracellular_ion_concentrations (millimolar). C ALGBRC(48) is J_tr in component intracellular_and_SR_Ca_fluxes (millimolar_per_second). C ALGBRC(47) is J_xfer in component intracellular_and_SR_Ca_fluxes (millimolar_per_second). C ALGBRC(53) is J_trpn in component intracellular_and_SR_Ca_fluxes (millimolar_per_second). C CONSTS(49) is tau_tr in component intracellular_and_SR_Ca_fluxes (second). C CONSTS(50) is tau_xfer in component intracellular_and_SR_Ca_fluxes (second). C STATES(25) is HTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar). C STATES(26) is LTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar). C ALGBRC(49) is J_HTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar_per_second). C ALGBRC(52) is J_LTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar_per_second). C CONSTS(51) is HTRPN_tot in component intracellular_and_SR_Ca_fluxes (millimolar). C CONSTS(52) is LTRPN_tot in component intracellular_and_SR_Ca_fluxes (millimolar). C CONSTS(53) is k_htrpn_plus in component intracellular_and_SR_Ca_fluxes (millimolar_per_second). C CONSTS(54) is k_htrpn_minus in component intracellular_and_SR_Ca_fluxes (per_second). C CONSTS(55) is k_ltrpn_plus in component intracellular_and_SR_Ca_fluxes (millimolar_per_second). C CONSTS(56) is k_ltrpn_minus in component intracellular_and_SR_Ca_fluxes (per_second). C CONSTS(57) is V_myo in component intracellular_ion_concentrations (micro_litre). C CONSTS(58) is V_JSR in component intracellular_ion_concentrations (micro_litre). C CONSTS(59) is V_NSR in component intracellular_ion_concentrations (micro_litre). C CONSTS(60) is V_SS in component intracellular_ion_concentrations (micro_litre). C CONSTS(61) is K_mCMDN in component intracellular_ion_concentrations (millimolar). C CONSTS(62) is K_mCSQN in component intracellular_ion_concentrations (millimolar). C CONSTS(63) is K_mEGTA in component intracellular_ion_concentrations (millimolar). C CONSTS(64) is CMDN_tot in component intracellular_ion_concentrations (millimolar). C CONSTS(65) is CSQN_tot in component intracellular_ion_concentrations (millimolar). C CONSTS(66) is EGTA_tot in component intracellular_ion_concentrations (millimolar). C ALGBRC(54) is beta_i in component intracellular_ion_concentrations (millimolar). C ALGBRC(50) is beta_SS in component intracellular_ion_concentrations (millimolar). C ALGBRC(51) is beta_JSR in component intracellular_ion_concentrations (millimolar). C RATES(1) is d/dt V in component membrane (millivolt). C RATES(3) is d/dt m in component sodium_current_m_gate (dimensionless). C RATES(4) is d/dt h in component sodium_current_h_gate (dimensionless). C RATES(5) is d/dt j in component sodium_current_j_gate (dimensionless). C RATES(7) is d/dt d in component L_type_Ca_channel_d_gate (dimensionless). C RATES(8) is d/dt f_11 in component L_type_Ca_channel_f_11_gate (dimensionless). C RATES(9) is d/dt f_12 in component L_type_Ca_channel_f_12_gate (dimensionless). C RATES(10) is d/dt Ca_inact in component L_type_Ca_channel_Ca_inact_gate (dimensionless). C RATES(12) is d/dt r in component Ca_independent_transient_outward_K_current_r_gate (dimensionless). C RATES(13) is d/dt s in component Ca_independent_transient_outward_K_current_s_gate (dimensionless). C RATES(14) is d/dt s_slow in component Ca_independent_transient_outward_K_current_s_slow_gate (dimensionless). C RATES(15) is d/dt r_ss in component steady_state_outward_K_current_r_ss_gate (dimensionless). C RATES(16) is d/dt s_ss in component steady_state_outward_K_current_s_ss_gate (dimensionless). C RATES(17) is d/dt y in component hyperpolarisation_activated_current_y_gate (dimensionless). C RATES(21) is d/dt P_C1 in component SR_Ca_release_channel (dimensionless). C RATES(19) is d/dt P_O1 in component SR_Ca_release_channel (dimensionless). C RATES(20) is d/dt P_O2 in component SR_Ca_release_channel (dimensionless). C RATES(22) is d/dt P_C2 in component SR_Ca_release_channel (dimensionless). C RATES(25) is d/dt HTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar). C RATES(26) is d/dt LTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar). C RATES(18) is d/dt Ca_i in component intracellular_ion_concentrations (millimolar). C RATES(2) is d/dt Na_i in component intracellular_ion_concentrations (millimolar). C RATES(11) is d/dt K_i in component intracellular_ion_concentrations (millimolar). C RATES(6) is d/dt Ca_ss in component intracellular_ion_concentrations (millimolar). C RATES(23) is d/dt Ca_JSR in component intracellular_ion_concentrations (millimolar). C RATES(24) is d/dt Ca_NSR in component intracellular_ion_concentrations (millimolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = -80.50146 CONSTS(1) = 8314.5 CONSTS(2) = 295 CONSTS(3) = 96487 CONSTS(4) = 0.0001 CONSTS(5) = 1 CONSTS(6) = 5e-3 CONSTS(7) = -0.6 CONSTS(8) = 1.064 STATES(2) = 10.73519 CONSTS(9) = 140 STATES(3) = 0.004164108 STATES(4) = 0.6735613 STATES(5) = 0.6729362 CONSTS(10) = 0.025916 CONSTS(11) = 65 STATES(6) = 0.00008737212 STATES(7) = 0.000002171081 STATES(8) = 0.9999529 STATES(9) = 0.9999529 STATES(10) = 0.9913102 CONSTS(12) = 0.009 CONSTS(13) = 0.02975 CONSTS(14) = 0.69 CONSTS(15) = 0.31 CONSTS(16) = 5.4 STATES(11) = 139.2751 STATES(12) = 0.002191519 STATES(13) = 0.9842542 STATES(14) = 0.6421196 CONSTS(17) = 0.005929 STATES(15) = 0.002907171 STATES(16) = 0.3142767 CONSTS(18) = 0.024 CONSTS(19) = 0.00145 CONSTS(20) = 0.2 STATES(17) = 0.003578708 CONSTS(21) = 0.000100188 CONSTS(22) = 0.0000162 CONSTS(23) = 0.000138 CONSTS(24) = 65 CONSTS(25) = 1.2 STATES(18) = 0.00007901351 CONSTS(26) = 0.0504 CONSTS(27) = 1.5 CONSTS(28) = 10 CONSTS(29) = 0.004 CONSTS(30) = 0.000009984 CONSTS(31) = 0.0001 CONSTS(32) = 0.5 CONSTS(33) = 1.8e3 CONSTS(34) = 12.15e12 CONSTS(35) = 576 CONSTS(36) = 4.05e9 CONSTS(37) = 1930 CONSTS(38) = 100 CONSTS(39) = 0.8 STATES(19) = 0.0004327548 STATES(20) = 0.000000000606254 STATES(21) = 0.6348229 STATES(22) = 0.3647471 CONSTS(40) = 4 CONSTS(41) = 3 STATES(23) = 0.06607948 CONSTS(42) = 0.000168 CONSTS(43) = 3.29 CONSTS(44) = 0.032 CONSTS(45) = 0.9 CONSTS(46) = 0.55 CONSTS(47) = 1.2 CONSTS(48) = 1 STATES(24) = 0.06600742 CONSTS(49) = 0.0005747 CONSTS(50) = 0.0267 STATES(25) = 1.394301e-1 STATES(26) = 5.1619e-3 CONSTS(51) = 0.14 CONSTS(52) = 0.07 CONSTS(53) = 200000 CONSTS(54) = 0.066 CONSTS(55) = 40000 CONSTS(56) = 40 CONSTS(57) = 9.36e-6 CONSTS(58) = 0.056e-6 CONSTS(59) = 0.504e-6 CONSTS(60) = 1.2e-9 CONSTS(61) = 0.00238 CONSTS(62) = 0.8 CONSTS(63) = 0.00015 CONSTS(64) = 0.05 CONSTS(65) = 15 CONSTS(66) = 0 CONSTS(67) = 1.33000*CONSTS(8) CONSTS(68) = 0.464700*CONSTS(13) CONSTS(69) = 2.10000 CONSTS(70) = 1.00000 - CONSTS(20) CONSTS(71) = (EXP(CONSTS(9)/67.3000) - 1.00000)/7.00000 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(21) = - CONSTS(34)*STATES(6) ** CONSTS(40)*STATES(21)+ CONSTS(35)*STATES(19) RATES(19) = ( CONSTS(34)*STATES(6) ** CONSTS(40)*STATES(21) - ( CONSTS(35)*STATES(19)+ CONSTS(36)*STATES(6) ** CONSTS(41)*STATES(19)+ CONSTS(38)*STATES(19)))+ CONSTS(37)*STATES(20)+ CONSTS(39)*STATES(22) RATES(20) = CONSTS(36)*STATES(6) ** CONSTS(41)*STATES(19) - CONSTS(37)*STATES(20) RATES(22) = CONSTS(38)*STATES(19) - CONSTS(39)*STATES(22) ALGBRC(7) = 1.00000/(1.00000+STATES(6)/0.0100000) RATES(10) = (ALGBRC(7) - STATES(10))/CONSTS(12) ALGBRC(12) = 1.00000/(1.00000+EXP((STATES(1)+87.5000)/10.3000)) RATES(16) = (ALGBRC(12) - STATES(16))/CONSTS(69) ALGBRC(1) = 1.00000/(1.00000+EXP((STATES(1)+45.0000)/- 6.50000)) ALGBRC(15) = 0.00136000/(( 0.320000*(STATES(1)+47.1300))/(1.00000 - EXP( - 0.100000*(STATES(1)+47.1300)))+ 0.0800000*EXP(- STATES(1)/11.0000)) RATES(3) = (ALGBRC(1) - STATES(3))/ALGBRC(15) ALGBRC(2) = 1.00000/(1.00000+EXP((STATES(1)+76.1000)/6.07000)) ALGBRC(16) = TERNRY(STATES(1).GE.- 40.0000, 0.000453700*(1.00000+EXP(- (STATES(1)+10.6600)/11.1000)), 0.00349000/( 0.135000*EXP(- (STATES(1)+80.0000)/6.80000)+ 3.56000*EXP( 0.0790000*STATES(1))+ 310000.*EXP( 0.350000*STATES(1)))) RATES(4) = (ALGBRC(2) - STATES(4))/ALGBRC(16) ALGBRC(3) = 1.00000/(1.00000+EXP((STATES(1)+76.1000)/6.07000)) ALGBRC(17) = TERNRY(STATES(1).GE.- 40.0000, ( 0.0116300*(1.00000+EXP( - 0.100000*(STATES(1)+32.0000))))/EXP( - 2.53500e-07*STATES(1)), 0.00349000/( ((STATES(1)+37.7800)/(1.00000+EXP( 0.311000*(STATES(1)+79.2300))))*( - 127140.*EXP( 0.244400*STATES(1)) - 3.47400e-05*EXP( - 0.0439100*STATES(1)))+( 0.121200*EXP( - 0.0105200*STATES(1)))/(1.00000+EXP( - 0.137800*(STATES(1)+40.1400))))) RATES(5) = (ALGBRC(3) - STATES(5))/ALGBRC(17) ALGBRC(4) = 1.00000/(1.00000+EXP((STATES(1)+15.3000)/- 5.00000)) ALGBRC(18) = 0.00305000*EXP( - 0.00450000*STATES(1)+7.00000 ** 2.00000)+ 0.00105000*EXP( - 0.00200000*STATES(1) - 18.0000 ** 2.00000)+0.000250000 RATES(7) = (ALGBRC(4) - STATES(7))/ALGBRC(18) ALGBRC(5) = 1.00000/(1.00000+EXP((STATES(1)+26.7000)/5.40000)) ALGBRC(19) = 0.900000*( 0.105000*EXP(- (STATES(1)+45.0000)/12.0000 ** 2.00000)+0.0400000/(1.00000+EXP((- STATES(1)+25.0000)/25.0000))+0.0150000/(1.00000+EXP((STATES(1)+75.0000)/25.0000))+0.00170000) RATES(8) = (ALGBRC(5) - STATES(8))/ALGBRC(19) ALGBRC(6) = 1.00000/(1.00000+EXP((STATES(1)+26.7000)/5.40000)) ALGBRC(20) = 0.0410000*EXP(- (STATES(1)+47.0000)/12.0000 ** 2.00000)+0.0800000/(1.00000+EXP((STATES(1)+55.0000)/- 5.00000))+0.0150000/(1.00000+EXP((STATES(1)+75.0000)/25.0000))+0.00170000 RATES(9) = (ALGBRC(6) - STATES(9))/ALGBRC(20) ALGBRC(21) = 1.00000/( 45.1600*EXP( 0.0357700*(STATES(1)+50.0000))+ 98.9000*EXP( - 0.100000*(STATES(1)+38.0000))) ALGBRC(8) = 1.00000/(1.00000+EXP((STATES(1)+10.6000)/- 11.4200)) RATES(12) = (ALGBRC(8) - STATES(12))/ALGBRC(21) ALGBRC(22) = 0.350000*EXP(- (STATES(1)+70.0000)/15.0000 ** 2.00000)+0.0350000 ALGBRC(9) = 1.00000/(1.00000+EXP((STATES(1)+45.3000)/6.88410)) RATES(13) = (ALGBRC(9) - STATES(13))/ALGBRC(22) ALGBRC(23) = 3.70000*EXP(( (- (STATES(1)+70.0000)/30.0000)*(STATES(1)+70.0000))/15.0000)+0.0350000 ALGBRC(10) = 1.00000/(1.00000+EXP((STATES(1)+45.3000)/6.88410)) RATES(14) = (ALGBRC(10) - STATES(14))/ALGBRC(23) ALGBRC(24) = 10.0000/( 45.1600*EXP( 0.0357700*(STATES(1)+50.0000))+ 98.9000*EXP( - 0.100000*(STATES(1)+38.0000))) ALGBRC(11) = 1.00000/(1.00000+EXP((STATES(1)+11.5000)/- 11.8200)) RATES(15) = (ALGBRC(11) - STATES(15))/ALGBRC(24) ALGBRC(25) = 1.00000/( 0.118850*EXP((STATES(1)+80.0000)/28.3700)+ 0.562300*EXP((STATES(1)+80.0000)/- 14.1900)) ALGBRC(13) = 1.00000/(1.00000+EXP((STATES(1)+138.600)/10.4800)) RATES(17) = (ALGBRC(13) - STATES(17))/ALGBRC(25) ALGBRC(29) = (( CONSTS(1)*CONSTS(2))/CONSTS(3))*log(CONSTS(16)/STATES(11)) ALGBRC(30) = CONSTS(13)*STATES(12)*( CONSTS(14)*STATES(13)+ CONSTS(15)*STATES(14))*(STATES(1) - ALGBRC(29)) ALGBRC(31) = CONSTS(17)*STATES(15)*STATES(16)*(STATES(1) - ALGBRC(29)) ALGBRC(32) = ( (48.0000/(EXP((STATES(1)+37.0000)/25.0000)+EXP((STATES(1)+37.0000)/- 25.0000))+10.0000)*0.00100000)/(1.00000+EXP((STATES(1) - (ALGBRC(29)+76.7700))/- 17.0000))+( CONSTS(18)*(STATES(1) - (ALGBRC(29)+1.73000)))/( (1.00000+EXP(( 1.61300*CONSTS(3)*(STATES(1) - (ALGBRC(29)+1.73000)))/( CONSTS(1)*CONSTS(2))))*(1.00000+EXP((CONSTS(16) - 0.998800)/- 0.124000))) ALGBRC(40) = ( (( (( CONSTS(26)*1.00000)/(1.00000+ 0.124500*EXP(( - 0.100000*STATES(1)*CONSTS(3))/( CONSTS(1)*CONSTS(2)))+ 0.0365000*CONSTS(71)*EXP(( - STATES(1)*CONSTS(3))/( CONSTS(1)*CONSTS(2)))))*CONSTS(16))/(CONSTS(16)+CONSTS(27)))*1.00000)/(1.00000+CONSTS(28)/STATES(2) ** 1.50000) ALGBRC(34) = CONSTS(19)*STATES(17)*CONSTS(70)*(STATES(1) - ALGBRC(29)) ALGBRC(38) = CONSTS(23)*(STATES(1) - ALGBRC(29)) RATES(11) = ( - (ALGBRC(31)+ALGBRC(38)+ALGBRC(30)+ALGBRC(32)+ALGBRC(34)+ ALGBRC(40)*- 2.00000)*1.00000)/( CONSTS(57)*CONSTS(3)) ALGBRC(26) = (( CONSTS(1)*CONSTS(2))/CONSTS(3))*log(CONSTS(9)/STATES(2)) ALGBRC(27) = CONSTS(8)*STATES(3) ** 3.00000*STATES(4)*STATES(5)*(STATES(1) - ALGBRC(26)) ALGBRC(28) = CONSTS(10)*STATES(7)*( (0.900000+STATES(10)/10.0000)*STATES(8)+ (0.100000 - STATES(10)/10.0000)*STATES(9))*(STATES(1) - CONSTS(11)) ALGBRC(33) = CONSTS(19)*STATES(17)*CONSTS(20)*(STATES(1) - ALGBRC(26)) ALGBRC(35) = ALGBRC(33)+ALGBRC(34) ALGBRC(36) = CONSTS(21)*(STATES(1) - ALGBRC(26)) ALGBRC(37) = CONSTS(22)*(STATES(1) - CONSTS(24)) ALGBRC(39) = ALGBRC(36)+ALGBRC(37)+ALGBRC(38) ALGBRC(42) = ( CONSTS(30)*( STATES(2) ** 3.00000*CONSTS(25)*EXP( 0.0374300*STATES(1)*CONSTS(32)) - CONSTS(9) ** 3.00000*STATES(18)*EXP( 0.0374300*STATES(1)*(CONSTS(32) - 1.00000))))/(1.00000+ CONSTS(31)*( STATES(18)*CONSTS(9) ** 3.00000+ CONSTS(25)*STATES(2) ** 3.00000)) ALGBRC(41) = ( CONSTS(29)*STATES(18))/(STATES(18)+0.000400000) ALGBRC(14) = TERNRY(VOI - INT(VOI/CONSTS(5))*CONSTS(5).GE.0.00000.AND.VOI - INT(VOI/CONSTS(5))*CONSTS(5).LE.CONSTS(6), CONSTS(7), 0.00000) RATES(1) = - (ALGBRC(27)+ALGBRC(28)+ALGBRC(30)+ALGBRC(31)+ALGBRC(35)+ALGBRC(32)+ALGBRC(39)+ALGBRC(40)+ALGBRC(42)+ALGBRC(41)+ALGBRC(14))/CONSTS(4) RATES(2) = ( - (ALGBRC(27)+ALGBRC(36)+ ALGBRC(42)*3.00000+ ALGBRC(40)*3.00000+ALGBRC(33))*1.00000)/( CONSTS(57)*CONSTS(3)) ALGBRC(44) = STATES(18)/CONSTS(42) ** CONSTS(47) ALGBRC(45) = STATES(24)/CONSTS(43) ** CONSTS(48) ALGBRC(46) = ( CONSTS(46)*( CONSTS(44)*ALGBRC(44) - CONSTS(45)*ALGBRC(45)))/(1.00000+ALGBRC(44)+ALGBRC(45)) ALGBRC(48) = (STATES(24) - STATES(23))/CONSTS(49) RATES(24) = ( ALGBRC(46)*CONSTS(57))/CONSTS(59) - ( ALGBRC(48)*CONSTS(58))/CONSTS(59) ALGBRC(49) = CONSTS(53)*STATES(18)*(CONSTS(51) - STATES(25)) - CONSTS(54)*STATES(25) RATES(25) = ALGBRC(49) ALGBRC(43) = CONSTS(33)*(STATES(19)+STATES(20))*(STATES(23) - STATES(6)) ALGBRC(47) = (STATES(6) - STATES(18))/CONSTS(50) ALGBRC(50) = 1.00000/(1.00000+( CONSTS(64)*CONSTS(61))/CONSTS(61)+STATES(6) ** 2.00000) RATES(6) = ALGBRC(50)*((( ALGBRC(43)*CONSTS(58))/CONSTS(60) - ( ALGBRC(47)*CONSTS(57))/CONSTS(60)) - ( ALGBRC(28)*1.00000)/( 2.00000*CONSTS(60)*CONSTS(3))) ALGBRC(51) = 1.00000/(1.00000+( CONSTS(65)*CONSTS(62))/CONSTS(62)+STATES(23) ** 2.00000) RATES(23) = ALGBRC(51)*(ALGBRC(48) - ALGBRC(43)) ALGBRC(52) = CONSTS(55)*STATES(18)*(CONSTS(52) - STATES(26)) - CONSTS(56)*STATES(26) RATES(26) = ALGBRC(52) ALGBRC(53) = ALGBRC(49)+ALGBRC(52) ALGBRC(54) = 1.00000/(1.00000+( CONSTS(64)*CONSTS(61))/CONSTS(61)+STATES(18) ** 2.00000+( CONSTS(66)*CONSTS(63))/CONSTS(63)+STATES(18) ** 2.00000) RATES(18) = ALGBRC(54)*(ALGBRC(47) - (ALGBRC(46)+ALGBRC(53)+( ((ALGBRC(37) - 2.00000*ALGBRC(42))+ALGBRC(41))*1.00000)/( 2.00000*CONSTS(57)*CONSTS(3)))) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(7) = 1.00000/(1.00000+STATES(6)/0.0100000) ALGBRC(12) = 1.00000/(1.00000+EXP((STATES(1)+87.5000)/10.3000)) ALGBRC(1) = 1.00000/(1.00000+EXP((STATES(1)+45.0000)/- 6.50000)) ALGBRC(15) = 0.00136000/(( 0.320000*(STATES(1)+47.1300))/(1.00000 - EXP( - 0.100000*(STATES(1)+47.1300)))+ 0.0800000*EXP(- STATES(1)/11.0000)) ALGBRC(2) = 1.00000/(1.00000+EXP((STATES(1)+76.1000)/6.07000)) ALGBRC(16) = TERNRY(STATES(1).GE.- 40.0000, 0.000453700*(1.00000+EXP(- (STATES(1)+10.6600)/11.1000)), 0.00349000/( 0.135000*EXP(- (STATES(1)+80.0000)/6.80000)+ 3.56000*EXP( 0.0790000*STATES(1))+ 310000.*EXP( 0.350000*STATES(1)))) ALGBRC(3) = 1.00000/(1.00000+EXP((STATES(1)+76.1000)/6.07000)) ALGBRC(17) = TERNRY(STATES(1).GE.- 40.0000, ( 0.0116300*(1.00000+EXP( - 0.100000*(STATES(1)+32.0000))))/EXP( - 2.53500e-07*STATES(1)), 0.00349000/( ((STATES(1)+37.7800)/(1.00000+EXP( 0.311000*(STATES(1)+79.2300))))*( - 127140.*EXP( 0.244400*STATES(1)) - 3.47400e-05*EXP( - 0.0439100*STATES(1)))+( 0.121200*EXP( - 0.0105200*STATES(1)))/(1.00000+EXP( - 0.137800*(STATES(1)+40.1400))))) ALGBRC(4) = 1.00000/(1.00000+EXP((STATES(1)+15.3000)/- 5.00000)) ALGBRC(18) = 0.00305000*EXP( - 0.00450000*STATES(1)+7.00000 ** 2.00000)+ 0.00105000*EXP( - 0.00200000*STATES(1) - 18.0000 ** 2.00000)+0.000250000 ALGBRC(5) = 1.00000/(1.00000+EXP((STATES(1)+26.7000)/5.40000)) ALGBRC(19) = 0.900000*( 0.105000*EXP(- (STATES(1)+45.0000)/12.0000 ** 2.00000)+0.0400000/(1.00000+EXP((- STATES(1)+25.0000)/25.0000))+0.0150000/(1.00000+EXP((STATES(1)+75.0000)/25.0000))+0.00170000) ALGBRC(6) = 1.00000/(1.00000+EXP((STATES(1)+26.7000)/5.40000)) ALGBRC(20) = 0.0410000*EXP(- (STATES(1)+47.0000)/12.0000 ** 2.00000)+0.0800000/(1.00000+EXP((STATES(1)+55.0000)/- 5.00000))+0.0150000/(1.00000+EXP((STATES(1)+75.0000)/25.0000))+0.00170000 ALGBRC(21) = 1.00000/( 45.1600*EXP( 0.0357700*(STATES(1)+50.0000))+ 98.9000*EXP( - 0.100000*(STATES(1)+38.0000))) ALGBRC(8) = 1.00000/(1.00000+EXP((STATES(1)+10.6000)/- 11.4200)) ALGBRC(22) = 0.350000*EXP(- (STATES(1)+70.0000)/15.0000 ** 2.00000)+0.0350000 ALGBRC(9) = 1.00000/(1.00000+EXP((STATES(1)+45.3000)/6.88410)) ALGBRC(23) = 3.70000*EXP(( (- (STATES(1)+70.0000)/30.0000)*(STATES(1)+70.0000))/15.0000)+0.0350000 ALGBRC(10) = 1.00000/(1.00000+EXP((STATES(1)+45.3000)/6.88410)) ALGBRC(24) = 10.0000/( 45.1600*EXP( 0.0357700*(STATES(1)+50.0000))+ 98.9000*EXP( - 0.100000*(STATES(1)+38.0000))) ALGBRC(11) = 1.00000/(1.00000+EXP((STATES(1)+11.5000)/- 11.8200)) ALGBRC(25) = 1.00000/( 0.118850*EXP((STATES(1)+80.0000)/28.3700)+ 0.562300*EXP((STATES(1)+80.0000)/- 14.1900)) ALGBRC(13) = 1.00000/(1.00000+EXP((STATES(1)+138.600)/10.4800)) ALGBRC(29) = (( CONSTS(1)*CONSTS(2))/CONSTS(3))*log(CONSTS(16)/STATES(11)) ALGBRC(30) = CONSTS(13)*STATES(12)*( CONSTS(14)*STATES(13)+ CONSTS(15)*STATES(14))*(STATES(1) - ALGBRC(29)) ALGBRC(31) = CONSTS(17)*STATES(15)*STATES(16)*(STATES(1) - ALGBRC(29)) ALGBRC(32) = ( (48.0000/(EXP((STATES(1)+37.0000)/25.0000)+EXP((STATES(1)+37.0000)/- 25.0000))+10.0000)*0.00100000)/(1.00000+EXP((STATES(1) - (ALGBRC(29)+76.7700))/- 17.0000))+( CONSTS(18)*(STATES(1) - (ALGBRC(29)+1.73000)))/( (1.00000+EXP(( 1.61300*CONSTS(3)*(STATES(1) - (ALGBRC(29)+1.73000)))/( CONSTS(1)*CONSTS(2))))*(1.00000+EXP((CONSTS(16) - 0.998800)/- 0.124000))) ALGBRC(40) = ( (( (( CONSTS(26)*1.00000)/(1.00000+ 0.124500*EXP(( - 0.100000*STATES(1)*CONSTS(3))/( CONSTS(1)*CONSTS(2)))+ 0.0365000*CONSTS(71)*EXP(( - STATES(1)*CONSTS(3))/( CONSTS(1)*CONSTS(2)))))*CONSTS(16))/(CONSTS(16)+CONSTS(27)))*1.00000)/(1.00000+CONSTS(28)/STATES(2) ** 1.50000) ALGBRC(34) = CONSTS(19)*STATES(17)*CONSTS(70)*(STATES(1) - ALGBRC(29)) ALGBRC(38) = CONSTS(23)*(STATES(1) - ALGBRC(29)) ALGBRC(26) = (( CONSTS(1)*CONSTS(2))/CONSTS(3))*log(CONSTS(9)/STATES(2)) ALGBRC(27) = CONSTS(8)*STATES(3) ** 3.00000*STATES(4)*STATES(5)*(STATES(1) - ALGBRC(26)) ALGBRC(28) = CONSTS(10)*STATES(7)*( (0.900000+STATES(10)/10.0000)*STATES(8)+ (0.100000 - STATES(10)/10.0000)*STATES(9))*(STATES(1) - CONSTS(11)) ALGBRC(33) = CONSTS(19)*STATES(17)*CONSTS(20)*(STATES(1) - ALGBRC(26)) ALGBRC(35) = ALGBRC(33)+ALGBRC(34) ALGBRC(36) = CONSTS(21)*(STATES(1) - ALGBRC(26)) ALGBRC(37) = CONSTS(22)*(STATES(1) - CONSTS(24)) ALGBRC(39) = ALGBRC(36)+ALGBRC(37)+ALGBRC(38) ALGBRC(42) = ( CONSTS(30)*( STATES(2) ** 3.00000*CONSTS(25)*EXP( 0.0374300*STATES(1)*CONSTS(32)) - CONSTS(9) ** 3.00000*STATES(18)*EXP( 0.0374300*STATES(1)*(CONSTS(32) - 1.00000))))/(1.00000+ CONSTS(31)*( STATES(18)*CONSTS(9) ** 3.00000+ CONSTS(25)*STATES(2) ** 3.00000)) ALGBRC(41) = ( CONSTS(29)*STATES(18))/(STATES(18)+0.000400000) ALGBRC(14) = TERNRY(VOI - INT(VOI/CONSTS(5))*CONSTS(5).GE.0.00000.AND.VOI - INT(VOI/CONSTS(5))*CONSTS(5).LE.CONSTS(6), CONSTS(7), 0.00000) ALGBRC(44) = STATES(18)/CONSTS(42) ** CONSTS(47) ALGBRC(45) = STATES(24)/CONSTS(43) ** CONSTS(48) ALGBRC(46) = ( CONSTS(46)*( CONSTS(44)*ALGBRC(44) - CONSTS(45)*ALGBRC(45)))/(1.00000+ALGBRC(44)+ALGBRC(45)) ALGBRC(48) = (STATES(24) - STATES(23))/CONSTS(49) ALGBRC(49) = CONSTS(53)*STATES(18)*(CONSTS(51) - STATES(25)) - CONSTS(54)*STATES(25) ALGBRC(43) = CONSTS(33)*(STATES(19)+STATES(20))*(STATES(23) - STATES(6)) ALGBRC(47) = (STATES(6) - STATES(18))/CONSTS(50) ALGBRC(50) = 1.00000/(1.00000+( CONSTS(64)*CONSTS(61))/CONSTS(61)+STATES(6) ** 2.00000) ALGBRC(51) = 1.00000/(1.00000+( CONSTS(65)*CONSTS(62))/CONSTS(62)+STATES(23) ** 2.00000) ALGBRC(52) = CONSTS(55)*STATES(18)*(CONSTS(52) - STATES(26)) - CONSTS(56)*STATES(26) ALGBRC(53) = ALGBRC(49)+ALGBRC(52) ALGBRC(54) = 1.00000/(1.00000+( CONSTS(64)*CONSTS(61))/CONSTS(61)+STATES(18) ** 2.00000+( CONSTS(66)*CONSTS(63))/CONSTS(63)+STATES(18) ** 2.00000) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END