2007-12-04T15:19:56+13:00
cardiac
ventricular myocyte
calcium dynamics
electrophysiology
guinea pig
Journal of Physiology
Units checked, curated.
Remodelling of Calcium Dynamics in Guinea-Pig Ventricular Cells
Note that the missing i_NCX_ds component was added to the dCai/dt rather than the dCads/dt equation in order to achieve balance in the model.
Noble
Penny
J
James Lawson
Lawson
James
Richard
Noble
Penny
J
penny.noble@dpag.ox.ac.uk
Oxford University
Department of Physiology, Anatomy & Genetics
Department of Physiology, Anatomy & Genetics, University of Oxford
Noble
Penny
2001-01-01
This version of the model has been curated and unit checked and is known to run in PCEnv, COR and Jsim. A PCEnv session file is also available for this model.
INaCads was not included in the dCads/dt ODE and hence the system was out
of balance. This issue has been fixed in version 05
Penny
Noble
Dennis
Noble
100000
0.001
2008-05-14T03:19:46+12:00
2007-05-17T00:00:00+00:00
The Noble98 (Noble et al. 1998) model of the guinea-pig ventricular cell was a development of the Noble91 (Noble et al. 1991) model and included representation of the components of IK, (IKr and IKs), the persistent sodium current and a dyadic space between the sarcolemma and the sarcoplasmic reticulum. In several important respects this model was a major improvement on the earlier model. However on rigorous testing for new applications problems associated with the calcium dynamics equations were found in the new model.
The model demonstrated here is an attempt at 'correcting' the inability of Noble98 to reproduce a mechanism of initiation of Early After-Depolarizations (EADs), the voltage-dependence of calcium release from the sarcoplasmic reticulum (SR) and also to improve the shape of the calcium transient.
James Lawson
keyword
2007-09-06T10:33:50+12:00