C C There are a total of 6 entries in the algebraic variable array. C There are a total of 3 entries in each of the rate and state variable arrays. C There are a total of 28 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(28) is v_GK in component v_GK (flux). C CONSTS(1) is V_GK_min in component v_GK (enzyme_activity). C CONSTS(25) is V_GK in component v_GK (enzyme_activity). C CONSTS(2) is Sgk in component v_GK (millimolar). C CONSTS(3) is h_GK in component v_GK (dimensionless). C CONSTS(27) is Glc in component Glc (millimolar). C CONSTS(4) is min_to_sec in component model_parameters (dimensionless). C CONSTS(5) is dw_per_ml in component model_parameters (dimensionless). C ALGBRC(2) is v_PFK in component v_PFK (flux). C CONSTS(6) is V_PFK_min in component v_PFK (enzyme_activity). C CONSTS(23) is V_PFK in component v_PFK (enzyme_activity). C CONSTS(7) is Spfk in component v_PFK (millimolar). C CONSTS(8) is Sfba in component v_PFK (millimolar). C CONSTS(9) is Xpfk in component v_PFK (millimolar). C CONSTS(10) is hx in component v_PFK (dimensionless). C CONSTS(11) is alpha in component v_PFK (dimensionless). C CONSTS(12) is h_PFK in component v_PFK (dimensionless). C CONSTS(13) is h_act in component v_PFK (dimensionless). C STATES(1) is FBP in component FBP (millimolar). C ALGBRC(1) is F6P in component F6P (millimolar). C ALGBRC(6) is v_FBA in component v_FBA (flux). C CONSTS(14) is V_FBA_min in component v_FBA (enzyme_activity). C CONSTS(24) is V_FBA in component v_FBA (enzyme_activity). C CONSTS(15) is Qfba in component v_FBA (millimolar). C CONSTS(16) is Sfba in component v_FBA (millimolar). C CONSTS(17) is Pfba in component v_FBA (millimolar). C CONSTS(18) is Keq_FBA in component v_FBA (millimolar). C ALGBRC(3) is G3P in component G3P (millimolar). C ALGBRC(5) is DHAP in component DHAP (millimolar). C ALGBRC(4) is v_GAPDH in component v_GAPDH (flux). C CONSTS(19) is V_GAPDH_min in component v_GAPDH (enzyme_activity). C CONSTS(26) is V_GAPDH in component v_GAPDH (enzyme_activity). C CONSTS(20) is Sgapdh in component v_GAPDH (millimolar). C STATES(2) is G6P_F6P in component G6P_F6P (millimolar). C CONSTS(21) is Keq_GPI in component F6P (dimensionless). C STATES(3) is DHAP_G3P in component DHAP_G3P (millimolar). C CONSTS(22) is Keq_TPI in component G3P (dimensionless). C RATES(2) is d/dt G6P_F6P in component G6P_F6P (millimolar). C RATES(1) is d/dt FBP in component FBP (millimolar). C RATES(3) is d/dt DHAP_G3P in component DHAP_G3P (millimolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 10.0 CONSTS(2) = 8.0 CONSTS(3) = 1.7 CONSTS(4) = 60.0 CONSTS(5) = 0.3333 CONSTS(6) = 100.0 CONSTS(7) = 4.0 CONSTS(8) = 0.005 CONSTS(9) = 0.01 CONSTS(10) = 2.5 CONSTS(11) = 5.0 CONSTS(12) = 2.5 CONSTS(13) = 1.0 STATES(1) = 0.00063612 CONSTS(14) = 25.0 CONSTS(15) = 0.275 CONSTS(16) = 0.005 CONSTS(17) = 0.5 CONSTS(18) = 0.1 CONSTS(19) = 250.0 CONSTS(20) = 0.005 STATES(2) = 3.71728 CONSTS(21) = 0.3 STATES(3) = 0.00262966 CONSTS(22) = 0.045455 CONSTS(23) = ( CONSTS(6)*CONSTS(5))/CONSTS(4) CONSTS(24) = ( CONSTS(14)*CONSTS(5))/CONSTS(4) CONSTS(25) = ( CONSTS(1)*CONSTS(5))/CONSTS(4) CONSTS(26) = ( CONSTS(19)*CONSTS(5))/CONSTS(4) CONSTS(27) = 10.0000 CONSTS(28) = ( CONSTS(25)*CONSTS(27)/CONSTS(2) ** CONSTS(3))/(1.00000+CONSTS(27)/CONSTS(2) ** CONSTS(3)) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( STATES(2)*CONSTS(21))/(1.00000+CONSTS(21)) ALGBRC(2) = ( CONSTS(23)*ALGBRC(1)/CONSTS(7) ** CONSTS(12) - (CONSTS(12) - CONSTS(13))*((STATES(1)/CONSTS(8))/(1.00000+STATES(1)/CONSTS(8))))/(ALGBRC(1)/CONSTS(7) ** CONSTS(12) - (CONSTS(12) - CONSTS(13))*((STATES(1)/CONSTS(8))/(1.00000+STATES(1)/CONSTS(8)))+(1.00000+STATES(1)/CONSTS(9) ** CONSTS(10))/(1.00000+ CONSTS(11) ** CONSTS(12) - (CONSTS(12) - CONSTS(13))*((STATES(1)/CONSTS(8))/(1.00000+STATES(1)/CONSTS(8)))*STATES(1)/CONSTS(9) ** CONSTS(10))) RATES(2) = CONSTS(28) - ALGBRC(2) ALGBRC(3) = ( STATES(3)*CONSTS(22))/(1.00000+CONSTS(22)) ALGBRC(5) = STATES(3) - ALGBRC(3) ALGBRC(6) = ( CONSTS(24)*(STATES(1)/CONSTS(16) - ( ALGBRC(3)*ALGBRC(5))/( CONSTS(17)*CONSTS(15)*CONSTS(18))))/(1.00000+STATES(1)/CONSTS(16)+ALGBRC(5)/CONSTS(15)+( ALGBRC(3)*ALGBRC(5))/( CONSTS(17)*CONSTS(15))) RATES(1) = ALGBRC(2) - ALGBRC(6) ALGBRC(4) = ( CONSTS(26)*ALGBRC(3))/(CONSTS(20)+ALGBRC(3)) RATES(3) = 2.00000*ALGBRC(6) - ALGBRC(4) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( STATES(2)*CONSTS(21))/(1.00000+CONSTS(21)) ALGBRC(2) = ( CONSTS(23)*ALGBRC(1)/CONSTS(7) ** CONSTS(12) - (CONSTS(12) - CONSTS(13))*((STATES(1)/CONSTS(8))/(1.00000+STATES(1)/CONSTS(8))))/(ALGBRC(1)/CONSTS(7) ** CONSTS(12) - (CONSTS(12) - CONSTS(13))*((STATES(1)/CONSTS(8))/(1.00000+STATES(1)/CONSTS(8)))+(1.00000+STATES(1)/CONSTS(9) ** CONSTS(10))/(1.00000+ CONSTS(11) ** CONSTS(12) - (CONSTS(12) - CONSTS(13))*((STATES(1)/CONSTS(8))/(1.00000+STATES(1)/CONSTS(8)))*STATES(1)/CONSTS(9) ** CONSTS(10))) ALGBRC(3) = ( STATES(3)*CONSTS(22))/(1.00000+CONSTS(22)) ALGBRC(5) = STATES(3) - ALGBRC(3) ALGBRC(6) = ( CONSTS(24)*(STATES(1)/CONSTS(16) - ( ALGBRC(3)*ALGBRC(5))/( CONSTS(17)*CONSTS(15)*CONSTS(18))))/(1.00000+STATES(1)/CONSTS(16)+ALGBRC(5)/CONSTS(15)+( ALGBRC(3)*ALGBRC(5))/( CONSTS(17)*CONSTS(15))) ALGBRC(4) = ( CONSTS(26)*ALGBRC(3))/(CONSTS(20)+ALGBRC(3)) RETURN END