C C There are a total of 26 entries in the algebraic variable array. C There are a total of 12 entries in each of the rate and state variable arrays. C There are a total of 37 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is V_s in component soma_compartment (mV). C CONSTS(1) is V_Na in component soma_compartment (mV). C ALGBRC(26) is I_Na_s in component soma_compartment (uA_per_cm2). C ALGBRC(1) is I_K_DR_s in component soma_compartment (uA_per_cm2). C ALGBRC(11) is I_Ca_T in component soma_compartment (uA_per_cm2). C ALGBRC(16) is I_K_Ca in component soma_compartment (uA_per_cm2). C ALGBRC(18) is I_A in component soma_compartment (uA_per_cm2). C ALGBRC(21) is I_h in component soma_compartment (uA_per_cm2). C CONSTS(2) is g_Na_s in component soma_compartment (mS_per_cm2). C CONSTS(3) is g_K_DR_s in component soma_compartment (mS_per_cm2). C CONSTS(4) is g_Ca_T in component soma_compartment (mS_per_cm2). C CONSTS(5) is g_K_Ca in component soma_compartment (mS_per_cm2). C CONSTS(6) is g_A in component soma_compartment (mS_per_cm2). C CONSTS(7) is g_h in component soma_compartment (mS_per_cm2). C STATES(2) is Ca in component soma_compartment (mM). C CONSTS(8) is k_Ca in component soma_compartment (per_second). C CONSTS(9) is K_Ca in component soma_compartment (mM). C CONSTS(10) is V_h in component soma_compartment (mV). C CONSTS(11) is beta in component soma_compartment (mMcm2_per_uAs). C CONSTS(12) is I_APP in component soma_compartment (uA_per_cm2). C CONSTS(13) is V_Ca in component general_variables (mV). C CONSTS(14) is V_K in component general_variables (mV). C STATES(3) is n in component gating_variables (dimensionless). C STATES(4) is h in component gating_variables (dimensionless). C ALGBRC(23) is m_infinity in component gating_variables (dimensionless). C CONSTS(15) is g_c in component general_variables (mS_per_cm2). C CONSTS(16) is p in component general_variables (dimensionless). C STATES(5) is V_D in component dendritic_compartment (mV). C CONSTS(17) is C_m in component general_variables (uF_per_cm2). C STATES(6) is m_T in component gating_variables (dimensionless). C STATES(7) is h_T in component gating_variables (dimensionless). C STATES(8) is a in component gating_variables (dimensionless). C STATES(9) is b in component gating_variables (dimensionless). C STATES(10) is m_h in component gating_variables (dimensionless). C STATES(11) is Na in component dendritic_compartment (mM). C CONSTS(18) is K_p in component dendritic_compartment (mM). C ALGBRC(19) is I_L in component dendritic_compartment (uA_per_cm2). C ALGBRC(17) is I_pump in component dendritic_compartment (uA_per_cm2). C CONSTS(19) is R_pump in component dendritic_compartment (uA_per_cm2). C CONSTS(20) is Na_eq in component dendritic_compartment (mM). C ALGBRC(12) is phi_Na in component dendritic_compartment (dimensionless). C CONSTS(32) is phi_Na_eq in component dendritic_compartment (dimensionless). C CONSTS(21) is alpha in component dendritic_compartment (mMcm2_per_uAs). C ALGBRC(22) is I_NMDA in component dendritic_compartment (uA_per_cm2). C ALGBRC(20) is I_Na_NMDA in component dendritic_compartment (uA_per_cm2). C CONSTS(22) is g_NMDA in component dendritic_compartment (mS_per_cm2). C CONSTS(23) is g_Na_NMDA in component dendritic_compartment (mS_per_cm2). C CONSTS(24) is g_L in component dendritic_compartment (mS_per_cm2). C CONSTS(25) is Mg_o in component dendritic_compartment (mM). C CONSTS(26) is K_Mg in component dendritic_compartment (mM). C CONSTS(27) is q in component dendritic_compartment (mV). C CONSTS(28) is V_NMDA in component dendritic_compartment (mV). C CONSTS(29) is V_L in component dendritic_compartment (mV). C ALGBRC(24) is I_D in component dendritic_compartment (uA_per_cm2). C ALGBRC(25) is I_Ca_L in component dendritic_compartment (uA_per_cm2). C CONSTS(30) is g_Ca_L in component dendritic_compartment (mS_per_cm2). C CONSTS(31) is g_K_DR_D in component dendritic_compartment (mS_per_cm2). C ALGBRC(2) is I_K_DR_D in component dendritic_compartment (uA_per_cm2). C STATES(12) is m_L in component gating_variables (dimensionless). C ALGBRC(3) is m_T_infinity in component gating_variables (dimensionless). C ALGBRC(4) is h_T_infinity in component gating_variables (dimensionless). C ALGBRC(5) is a_infinity in component gating_variables (dimensionless). C ALGBRC(6) is b_infinity in component gating_variables (dimensionless). C ALGBRC(7) is m_h_infinity in component gating_variables (dimensionless). C ALGBRC(8) is m_L_infinity in component gating_variables (dimensionless). C ALGBRC(9) is n_infinity in component gating_variables (dimensionless). C ALGBRC(10) is h_infinity in component gating_variables (dimensionless). C ALGBRC(13) is tau_h in component gating_variables (second). C ALGBRC(14) is tau_n in component gating_variables (second). C CONSTS(33) is tau_m_T in component gating_variables (second). C CONSTS(34) is tau_h_T in component gating_variables (second). C ALGBRC(15) is tau_m_L in component gating_variables (second). C CONSTS(35) is tau_a in component gating_variables (second). C CONSTS(36) is tau_b in component gating_variables (second). C CONSTS(37) is tau_m_h in component gating_variables (second). C RATES(1) is d/dt V_s in component soma_compartment (mV). C RATES(2) is d/dt Ca in component soma_compartment (mM). C RATES(5) is d/dt V_D in component dendritic_compartment (mV). C RATES(11) is d/dt Na in component dendritic_compartment (mM). C RATES(4) is d/dt h in component gating_variables (dimensionless). C RATES(3) is d/dt n in component gating_variables (dimensionless). C RATES(6) is d/dt m_T in component gating_variables (dimensionless). C RATES(12) is d/dt m_L in component gating_variables (dimensionless). C RATES(10) is d/dt m_h in component gating_variables (dimensionless). C RATES(8) is d/dt a in component gating_variables (dimensionless). C RATES(9) is d/dt b in component gating_variables (dimensionless). C RATES(7) is d/dt h_T in component gating_variables (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = -64.0 CONSTS(1) = 55 CONSTS(2) = 3.2 CONSTS(3) = 6.4 CONSTS(4) = 1.5 CONSTS(5) = 1.2 CONSTS(6) = 2 CONSTS(7) = 0.1 STATES(2) = 0 CONSTS(8) = 1 CONSTS(9) = 0.0004 CONSTS(10) = -30 CONSTS(11) = 0.104 CONSTS(12) = -6.7 CONSTS(13) = 120 CONSTS(14) = -85 STATES(3) = 0.002 STATES(4) = 1.0 CONSTS(15) = 0.1 CONSTS(16) = 0.5 STATES(5) = -77.0 CONSTS(17) = 1 STATES(6) = 0.1 STATES(7) = 0.1 STATES(8) = 0.1 STATES(9) = 0.1 STATES(10) = 0.1 STATES(11) = 5.09 CONSTS(18) = 15 CONSTS(19) = 18 CONSTS(20) = 8 CONSTS(21) = 0.173 CONSTS(22) = 25 CONSTS(23) = 5 CONSTS(24) = 0.18 CONSTS(25) = 1.4 CONSTS(26) = 10 CONSTS(27) = 12.5 CONSTS(28) = 0 CONSTS(29) = -50 CONSTS(30) = 0.19 CONSTS(31) = 0.14 STATES(12) = 0.1 CONSTS(32) = CONSTS(20) ** 3.00000/(CONSTS(20) ** 3.00000+CONSTS(18) ** 3.00000) CONSTS(33) = 1.00000 CONSTS(34) = 10.0000 CONSTS(35) = 0.500000 CONSTS(36) = 10.0000 CONSTS(37) = 190.000 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = 1.00000/(1.00000+EXP(- (STATES(1)+55.0000)/7.00000)) RATES(6) = (ALGBRC(3) - STATES(6))/CONSTS(33) ALGBRC(7) = 1.00000/(1.00000+EXP((STATES(1)+80.0000)/8.00000)) RATES(10) = (ALGBRC(7) - STATES(10))/CONSTS(37) ALGBRC(5) = 1.00000/(1.00000+EXP(- (STATES(1)+60.0000)/10.0000)) RATES(8) = (ALGBRC(5) - STATES(8))/CONSTS(35) ALGBRC(6) = 1.00000/(1.00000+EXP((STATES(1)+70.0000)/5.70000)) RATES(9) = (ALGBRC(6) - STATES(9))/CONSTS(36) ALGBRC(4) = 1.00000/(1.00000+EXP((STATES(1)+81.0000)/11.0000)) RATES(7) = (ALGBRC(4) - STATES(7))/CONSTS(34) ALGBRC(11) = CONSTS(4)*STATES(7)*(STATES(1) - CONSTS(13))*STATES(6) ** 2.00000 RATES(2) = - ( CONSTS(11)*ALGBRC(11)+ CONSTS(8)*STATES(2)) ALGBRC(10) = 1.00000/(1.00000+EXP((STATES(1)+30.0000)/8.30000)) ALGBRC(13) = 0.400000*(1.00000+2.00000/(1.00000+EXP((STATES(1)+25.0000)/5.00000))) RATES(4) = (ALGBRC(10) - STATES(4))/ALGBRC(13) ALGBRC(9) = 1.00000/(1.00000+EXP(- (STATES(1)+31.0000)/5.30000)) ALGBRC(14) = ( 0.800000*(1.00000+2.00000/(1.00000+EXP((STATES(1)+25.0000)/10.0000))))/(1.00000+EXP(- (STATES(1)+70.0000)/10.0000)) RATES(3) = (ALGBRC(9) - STATES(3))/ALGBRC(14) ALGBRC(8) = 1.00000/(1.00000+EXP(- (STATES(5)+20.0000)/5.30000)) ALGBRC(15) = 0.400000/( 5.00000*EXP(- (STATES(5)+11.0000)/8.30000)+(- (STATES(5)+11.0000)/8.30000)/(EXP(- (STATES(5)+11.0000)/8.30000) - 1.00000)) RATES(12) = (ALGBRC(8) - STATES(12))/ALGBRC(15) ALGBRC(12) = STATES(11) ** 3.00000/(STATES(11) ** 3.00000+CONSTS(18) ** 3.00000) ALGBRC(17) = CONSTS(19)*(ALGBRC(12) - CONSTS(32)) ALGBRC(20) = (CONSTS(23)/(1.00000+ (CONSTS(25)/CONSTS(26))*EXP(- STATES(5)/CONSTS(27))))*(STATES(5) - CONSTS(1)) RATES(11) = CONSTS(21)*(- ALGBRC(20) - ALGBRC(17)*3.00000) ALGBRC(19) = CONSTS(24)*(STATES(5) - CONSTS(29)) ALGBRC(22) = (CONSTS(22)/(1.00000+ (CONSTS(25)/CONSTS(26))*EXP(- STATES(5)/CONSTS(27))))*(STATES(5) - CONSTS(28)) ALGBRC(25) = CONSTS(30)*(STATES(5) - CONSTS(13))*STATES(12) ** 2.00000 ALGBRC(2) = CONSTS(31)*(STATES(5) - CONSTS(14))*STATES(3) ** 2.00000 RATES(5) = - ( 1000.00*(ALGBRC(25)+ALGBRC(2)+ALGBRC(22)+ALGBRC(17)+ALGBRC(19)+ (CONSTS(15)/(1.00000 - CONSTS(16)))*(STATES(5) - STATES(1))))/CONSTS(17) ALGBRC(23) = 1.00000/(1.00000+EXP(- (STATES(1)+35.0000)/6.20000)) ALGBRC(26) = CONSTS(2)*STATES(4)*(STATES(1) - CONSTS(1))*ALGBRC(23) ** 3.00000 ALGBRC(1) = CONSTS(3)*(STATES(1) - CONSTS(14))*STATES(3) ** 2.00000 ALGBRC(16) = (( CONSTS(5)*STATES(2) ** 4.00000)/(STATES(2) ** 4.00000+CONSTS(9) ** 4.00000))*(STATES(1) - CONSTS(14)) ALGBRC(18) = CONSTS(6)*STATES(9)*(STATES(1) - CONSTS(14))*STATES(8) ** 4.00000 ALGBRC(21) = CONSTS(7)*STATES(10)*(STATES(1) - CONSTS(10)) RATES(1) = ( 1000.00*(CONSTS(12) - (ALGBRC(26)+ALGBRC(11)+ALGBRC(1)+ALGBRC(16)+ALGBRC(18)+ALGBRC(21)+ (CONSTS(15)/CONSTS(16))*(STATES(1) - STATES(5)))))/CONSTS(17) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = 1.00000/(1.00000+EXP(- (STATES(1)+55.0000)/7.00000)) ALGBRC(7) = 1.00000/(1.00000+EXP((STATES(1)+80.0000)/8.00000)) ALGBRC(5) = 1.00000/(1.00000+EXP(- (STATES(1)+60.0000)/10.0000)) ALGBRC(6) = 1.00000/(1.00000+EXP((STATES(1)+70.0000)/5.70000)) ALGBRC(4) = 1.00000/(1.00000+EXP((STATES(1)+81.0000)/11.0000)) ALGBRC(11) = CONSTS(4)*STATES(7)*(STATES(1) - CONSTS(13))*STATES(6) ** 2.00000 ALGBRC(10) = 1.00000/(1.00000+EXP((STATES(1)+30.0000)/8.30000)) ALGBRC(13) = 0.400000*(1.00000+2.00000/(1.00000+EXP((STATES(1)+25.0000)/5.00000))) ALGBRC(9) = 1.00000/(1.00000+EXP(- (STATES(1)+31.0000)/5.30000)) ALGBRC(14) = ( 0.800000*(1.00000+2.00000/(1.00000+EXP((STATES(1)+25.0000)/10.0000))))/(1.00000+EXP(- (STATES(1)+70.0000)/10.0000)) ALGBRC(8) = 1.00000/(1.00000+EXP(- (STATES(5)+20.0000)/5.30000)) ALGBRC(15) = 0.400000/( 5.00000*EXP(- (STATES(5)+11.0000)/8.30000)+(- (STATES(5)+11.0000)/8.30000)/(EXP(- (STATES(5)+11.0000)/8.30000) - 1.00000)) ALGBRC(12) = STATES(11) ** 3.00000/(STATES(11) ** 3.00000+CONSTS(18) ** 3.00000) ALGBRC(17) = CONSTS(19)*(ALGBRC(12) - CONSTS(32)) ALGBRC(20) = (CONSTS(23)/(1.00000+ (CONSTS(25)/CONSTS(26))*EXP(- STATES(5)/CONSTS(27))))*(STATES(5) - CONSTS(1)) ALGBRC(19) = CONSTS(24)*(STATES(5) - CONSTS(29)) ALGBRC(22) = (CONSTS(22)/(1.00000+ (CONSTS(25)/CONSTS(26))*EXP(- STATES(5)/CONSTS(27))))*(STATES(5) - CONSTS(28)) ALGBRC(25) = CONSTS(30)*(STATES(5) - CONSTS(13))*STATES(12) ** 2.00000 ALGBRC(2) = CONSTS(31)*(STATES(5) - CONSTS(14))*STATES(3) ** 2.00000 ALGBRC(23) = 1.00000/(1.00000+EXP(- (STATES(1)+35.0000)/6.20000)) ALGBRC(26) = CONSTS(2)*STATES(4)*(STATES(1) - CONSTS(1))*ALGBRC(23) ** 3.00000 ALGBRC(1) = CONSTS(3)*(STATES(1) - CONSTS(14))*STATES(3) ** 2.00000 ALGBRC(16) = (( CONSTS(5)*STATES(2) ** 4.00000)/(STATES(2) ** 4.00000+CONSTS(9) ** 4.00000))*(STATES(1) - CONSTS(14)) ALGBRC(18) = CONSTS(6)*STATES(9)*(STATES(1) - CONSTS(14))*STATES(8) ** 4.00000 ALGBRC(21) = CONSTS(7)*STATES(10)*(STATES(1) - CONSTS(10)) ALGBRC(24) = ALGBRC(22)+ALGBRC(17)+ALGBRC(19) RETURN END