<?xml version="1.0"?>
<!--
This CellML file was generated on 27/04/2010 at 11:06:52 at a.m. using:
COR (0.9.31.1371)
Copyright 2002-2010 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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<articleinfo>
<title>Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress</title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
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<title>Model Status</title>
<para>
This CellML model runs in COR and OpenCell and the units are consistent throughout. It reproduces the published results and was converted from SBML with the help of Lukas Endler.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: BACKGROUND: Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role. RESULTS: We recently discovered that yeast cells with reduced activity of the key glycolytic enzyme triosephosphate isomerase exhibit an increased resistance to the thiol-oxidizing reagent diamide. Here we show that this phenotype is conserved in Caenorhabditis elegans and that the underlying mechanism is based on a redirection of the metabolic flux from glycolysis to the pentose phosphate pathway, altering the redox equilibrium of the cytoplasmic NADP(H) pool. Remarkably, another key glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), is known to be inactivated in response to various oxidant treatments, and we show that this provokes a similar redirection of the metabolic flux. CONCLUSION: The naturally occurring inactivation of GAPDH functions as a metabolic switch for rerouting the carbohydrate flux to counteract oxidative stress. As a consequence, altering the homoeostasis of cytoplasmic metabolites is a fundamental mechanism for balancing the redox state of eukaryotic cells under stress conditions.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress, Markus Ralser, Mirjam M Wamelink, Axel Kowald, Birgit Gerisch, Gino Heeren, Eduard A Struys, Edda Klipp, Cornelis Jakobs, Michael Breitenbach, Hans Lehrach and Sylvia Krobitsch, 2007, <emphasis>Journal of Biology</emphasis>, volume 6, 1-18. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=18154684&query_hl=1&itool=pubmed_docsum">PubMed ID: 18154684</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
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<caption>Schematic diagram of the reactions included in the mathematical model to study the effects of a diminished TPI or GAPDH activity on the flux through glycolysis and the pentose phosphate pathway. Substances with a dashed outline are assumed to have a constant concentration</caption>
</informalfigure>
</sect1>
</article>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KeqGLK</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>GLCi</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>KmGLKATP</ci>
<ci>KmGLKGLCi</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>G6P</ci>
<ci>KmGLKG6P</ci>
</apply>
<apply>
<divide/>
<ci>GLCi</ci>
<ci>KmGLKGLCi</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<minus/>
<ci>SUMAXP</ci>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmGLKADP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmGLKATP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vPGI">
<variable name="vPGI" public_interface="out" units="mmol_per_min"/>
<variable initial_value="339.677" name="VmPGI" units="mM_per_min"/>
<variable initial_value="1.4" name="KmPGIG6P" units="mM"/>
<variable initial_value="0.314" name="KeqPGI" units="dimensionless"/>
<variable initial_value="0.3" name="KmPGIF6P" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="G6P" public_interface="in" units="mM"/>
<variable name="F6P" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vPGI</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmPGI</ci>
</apply>
<ci>KmPGIG6P</ci>
</apply>
<apply>
<minus/>
<ci>G6P</ci>
<apply>
<divide/>
<ci>F6P</ci>
<ci>KeqPGI</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>G6P</ci>
<ci>KmPGIG6P</ci>
</apply>
<apply>
<divide/>
<ci>F6P</ci>
<ci>KmPGIF6P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vPFK">
<variable name="vPFK" public_interface="out" units="mmol_per_min"/>
<variable name="numerator1" units="mmol_mM2_per_minute"/>
<variable name="numerator2" units="dimensionless"/>
<variable name="denominator" units="mM2"/>
<variable name="denom1" units="dimensionless"/>
<variable name="denom2" units="dimensionless"/>
<variable name="denom3" units="dimensionless"/>
<variable initial_value="5.12" name="gR" units="dimensionless"/>
<variable initial_value="182.903" name="VmPFK" units="mM_per_min"/>
<variable initial_value="0.45" name="KeqAK" units="dimensionless"/>
<variable initial_value="0.1" name="KmPFKF6P" units="mM"/>
<variable initial_value="0.71" name="KmPFKATP" units="mM"/>
<variable initial_value="0.66" name="L0" units="dimensionless"/>
<variable initial_value="0.0174" name="CPFKF26BP" units="dimensionless"/>
<variable initial_value="0.000682" name="KPFKF26BP" units="mM"/>
<variable initial_value="0.397" name="CPFKF16BP" units="dimensionless"/>
<variable initial_value="0.111" name="KPFKF16BP" units="mM"/>
<variable initial_value="0.0845" name="CPFKAMP" units="dimensionless"/>
<variable initial_value="0.0995" name="KPFKAMP" units="mM"/>
<variable initial_value="100" name="CiPFKATP" units="dimensionless"/>
<variable initial_value="0.65" name="KiPFKATP" units="mM"/>
<variable initial_value="3" name="CPFKATP" units="dimensionless"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="F16P" public_interface="in" units="mM"/>
<variable name="F26BP" public_interface="in" units="mM"/>
<variable name="F6P" public_interface="in" units="mM"/>
<variable name="P" public_interface="in" units="mM"/>
<variable name="DHAP" public_interface="in" units="mM"/>
<variable name="SUMAXP" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>numerator1</ci>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>gR</ci>
<ci>VmPFK</ci>
<ci>F6P</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>numerator2</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>F6P</ci>
<ci>KmPFKF6P</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmPFKATP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>gR</ci>
<ci>F6P</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmPFKATP</ci>
<ci>KmPFKF6P</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denominator</ci>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmPFKATP</ci>
<ci>KmPFKF6P</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>L0</ci>
<ci>denom1</ci>
<ci>denom2</ci>
</apply>
<ci>denom3</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>F6P</ci>
<ci>KmPFKF6P</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmPFKATP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>gR</ci>
<ci>F6P</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmPFKATP</ci>
<ci>KmPFKF6P</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denom1</ci>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CPFKF26BP</ci>
<ci>F26BP</ci>
</apply>
<ci>KPFKF26BP</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>CPFKF16BP</ci>
<ci>F16P</ci>
</apply>
<ci>KPFKF16BP</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>CPFKAMP</ci>
<ci>KeqAK</ci>
<apply>
<power/>
<apply>
<minus/>
<ci>SUMAXP</ci>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KPFKAMP</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denom2</ci>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CiPFKATP</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KiPFKATP</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CPFKATP</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmPFKATP</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denom3</ci>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>F26BP</ci>
<ci>KPFKF26BP</ci>
</apply>
<apply>
<divide/>
<ci>F16P</ci>
<ci>KPFKF16BP</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<apply>
<minus/>
<ci>SUMAXP</ci>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KPFKAMP</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KiPFKATP</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>vPFK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>numerator1</ci>
<ci>numerator2</ci>
</apply>
<ci>denominator</ci>
</apply>
</apply>
</math>
</component>
<component name="vALD">
<variable name="vALD" public_interface="out" units="mmol_per_min"/>
<variable initial_value="322.258" name="VmALD" units="mM_per_min"/>
<variable initial_value="0.045" name="KeqTPI" units="dimensionless"/>
<variable initial_value="0.069" name="KeqALD" units="mM"/>
<variable initial_value="0.3" name="KmALDF16P" units="mM"/>
<variable initial_value="2.4" name="KmALDDHAP" units="mM"/>
<variable initial_value="2" name="KmALDGAP" units="mM"/>
<variable initial_value="10" name="KmALDGAPi" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="F16P" public_interface="in" units="mM"/>
<variable name="GA3P" public_interface="in" units="mM"/>
<variable name="DHAP" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vALD</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmALD</ci>
<ci>F16P</ci>
</apply>
<ci>KmALDF16P</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>DHAP</ci>
<ci>GA3P</ci>
</apply>
<apply>
<times/>
<ci>F16P</ci>
<ci>KeqALD</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>F16P</ci>
<ci>KmALDF16P</ci>
</apply>
<apply>
<divide/>
<ci>DHAP</ci>
<ci>KmALDDHAP</ci>
</apply>
<apply>
<divide/>
<ci>GA3P</ci>
<ci>KmALDGAP</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>F16P</ci>
<ci>GA3P</ci>
</apply>
<apply>
<times/>
<ci>KmALDF16P</ci>
<ci>KmALDGAPi</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>DHAP</ci>
<ci>GA3P</ci>
</apply>
<apply>
<times/>
<ci>KmALDDHAP</ci>
<ci>KmALDGAP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vG3PDH">
<variable name="vG3PDH" public_interface="out" units="mmol_per_min"/>
<variable initial_value="70.15" name="VmG3PDH" units="mM_per_min"/>
<variable initial_value="4300" name="KeqG3PDH" units="dimensionless"/>
<variable initial_value="0.045" name="KeqTPI" units="dimensionless"/>
<variable initial_value="0.4" name="KmG3PDHDHAP" units="mM"/>
<variable initial_value="0.023" name="KmG3PDHNADH" units="mM"/>
<variable initial_value="0.93" name="KmG3PDHNAD" units="mM"/>
<variable initial_value="1" name="KmG3PDHGLY" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="GLY" public_interface="in" units="mM"/>
<variable name="NAD" public_interface="in" units="mM"/>
<variable name="NADH" public_interface="in" units="mM"/>
<variable name="DHAP" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vG3PDH</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmG3PDH</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>GLY</ci>
</apply>
<ci>NAD</ci>
</apply>
<ci>KeqG3PDH</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>NADH</ci>
<ci>DHAP</ci>
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<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>KeqTPI</ci>
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</apply>
</apply>
</apply>
<apply>
<times/>
<ci>KmG3PDHDHAP</ci>
<ci>KmG3PDHNADH</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>NAD</ci>
<ci>KmG3PDHNAD</ci>
</apply>
<apply>
<divide/>
<ci>NADH</ci>
<ci>KmG3PDHNADH</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>GLY</ci>
<ci>KmG3PDHGLY</ci>
</apply>
<apply>
<divide/>
<ci>DHAP</ci>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>KeqTPI</ci>
</apply>
<ci>KmG3PDHDHAP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vGAPDH">
<variable name="vGAPDH" public_interface="out" units="mmol_per_min"/>
<variable initial_value="6549.68" name="VmGAPDHr" units="mM_per_min"/>
<variable initial_value="0.0098" name="KmGAPDHBPG" units="mM"/>
<variable initial_value="0.06" name="KmGAPDHNADH" units="mM"/>
<variable initial_value="0.045" name="KeqTPI" units="dimensionless"/>
<variable initial_value="1184.52" name="VmGAPDHf" units="mM_per_min"/>
<variable initial_value="0.21" name="KmGAPDHGAP" units="mM"/>
<variable initial_value="0.09" name="KmGAPDHNAD" units="mM"/>
<variable initial_value="0.005" name="KeqGAPDH" units="dimensionless"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="BPG" public_interface="in" units="mM"/>
<variable name="GA3P" public_interface="in" units="mM"/>
<variable name="NAD" public_interface="in" units="mM"/>
<variable name="NADH" public_interface="in" units="mM"/>
<variable name="k_rel_GAPDH" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vGAPDH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>k_rel_GAPDH</ci>
<ci>VmGAPDHf</ci>
<ci>GA3P</ci>
<ci>NAD</ci>
</apply>
<apply>
<times/>
<ci>KmGAPDHGAP</ci>
<ci>KmGAPDHNAD</ci>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>BPG</ci>
<ci>NADH</ci>
</apply>
<apply>
<times/>
<ci>GA3P</ci>
<ci>NAD</ci>
<ci>KeqGAPDH</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>GA3P</ci>
<ci>KmGAPDHGAP</ci>
</apply>
<apply>
<divide/>
<ci>BPG</ci>
<ci>KmGAPDHBPG</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>NAD</ci>
<ci>KmGAPDHNAD</ci>
</apply>
<apply>
<divide/>
<ci>NADH</ci>
<ci>KmGAPDHNADH</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vPGK">
<variable name="vPGK" public_interface="out" units="mmol_per_min"/>
<variable initial_value="1306.45" name="VmPGK" units="mM_per_min"/>
<variable initial_value="3200" name="KeqPGK" units="dimensionless"/>
<variable initial_value="0.45" name="KeqAK" units="dimensionless"/>
<variable initial_value="0.3" name="KmPGKATP" units="mM"/>
<variable initial_value="0.53" name="KmPGKP3G" units="mM"/>
<variable initial_value="0.2" name="KmPGKADP" units="mM"/>
<variable initial_value="0.003" name="KmPGKBPG" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="BPG" public_interface="in" units="mM"/>
<variable name="P" public_interface="in" units="mM"/>
<variable name="P3G" public_interface="in" units="mM"/>
<variable name="SUMAXP" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vPGK</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>cytoplasm</ci>
<ci>VmPGK</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>KeqPGK</ci>
<ci>BPG</ci>
<apply>
<minus/>
<ci>SUMAXP</ci>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
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<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>P3G</ci>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>KmPGKATP</ci>
<ci>KmPGKP3G</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<minus/>
<ci>SUMAXP</ci>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmPGKADP</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>SUMAXP</ci>
</apply>
<ci>P</ci>
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<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>SUMAXP</ci>
<ci>P</ci>
</apply>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
<ci>KmPGKATP</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>BPG</ci>
<ci>KmPGKBPG</ci>
</apply>
<apply>
<divide/>
<ci>P3G</ci>
<ci>KmPGKP3G</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vPGM">
<variable name="vPGM" public_interface="out" units="mmol_per_min"/>
<variable initial_value="2525.81" name="VmPGM" units="mM_per_min"/>
<variable initial_value="1.2" name="KmPGMP3G" units="mM"/>
<variable initial_value="0.19" name="KeqPGM" units="dimensionless"/>
<variable initial_value="0.08" name="KmPGMP2G" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="P2G" public_interface="in" units="mM"/>
<variable name="P3G" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vPGM</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmPGM</ci>
</apply>
<ci>KmPGMP3G</ci>
</apply>
<apply>
<minus/>
<ci>P3G</ci>
<apply>
<divide/>
<ci>P2G</ci>
<ci>KeqPGM</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>P3G</ci>
<ci>KmPGMP3G</ci>
</apply>
<apply>
<divide/>
<ci>P2G</ci>
<ci>KmPGMP2G</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vENO">
<variable name="vENO" public_interface="out" units="mmol_per_min"/>
<variable initial_value="365.806" name="VmENO" units="mM_per_min"/>
<variable initial_value="0.04" name="KmENOP2G" units="mM"/>
<variable initial_value="6.7" name="KeqENO" units="dimensionless"/>
<variable initial_value="0.5" name="KmENOPEP" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="P2G" public_interface="in" units="mM"/>
<variable name="PEP" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vENO</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmENO</ci>
</apply>
<ci>KmENOP2G</ci>
</apply>
<apply>
<minus/>
<ci>P2G</ci>
<apply>
<divide/>
<ci>PEP</ci>
<ci>KeqENO</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>P2G</ci>
<ci>KmENOP2G</ci>
</apply>
<apply>
<divide/>
<ci>PEP</ci>
<ci>KmENOPEP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vPYK">
<variable name="vPYK" public_interface="out" units="mmol_per_min"/>
<variable initial_value="1088.71" name="VmPYK" units="mM_per_min"/>
<variable initial_value="0.14" name="KmPYKPEP" units="mM"/>
<variable initial_value="0.53" name="KmPYKADP" units="mM"/>
<variable initial_value="0.45" name="KeqAK" units="dimensionless"/>
<variable initial_value="6500" name="KeqPYK" units="dimensionless"/>
<variable initial_value="21" name="KmPYKPYR" units="mM"/>
<variable initial_value="1.5" name="KmPYKATP" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="PEP" public_interface="in" units="mM"/>
<variable name="P" public_interface="in" units="mM"/>
<variable name="PYR" public_interface="in" units="mM"/>
<variable name="SUMAXP" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vPYK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmPYK</ci>
</apply>
<apply>
<times/>
<ci>KmPYKPEP</ci>
<ci>KmPYKADP</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>PEP</ci>
<apply>
<minus/>
<ci>SUMAXP</ci>
<apply>
<root/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
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<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
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</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>PYR</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>P</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<ci>SUMAXP</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
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<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
</apply>
<ci>KeqPYK</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>PEP</ci>
<ci>KmPYKPEP</ci>
</apply>
<apply>
<divide/>
<ci>PYR</ci>
<ci>KmPYKPYR</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>P</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<ci>SUMAXP</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
</apply>
<ci>KmPYKATP</ci>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<minus/>
<ci>SUMAXP</ci>
<apply>
<root/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
</apply>
</apply>
</apply>
<ci>KmPYKADP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vPDC">
<variable name="vPDC" public_interface="out" units="mmol_per_min"/>
<variable initial_value="174.194" name="VmPDC" units="mM_per_min"/>
<variable initial_value="1.9" name="nPDC" units="dimensionless"/>
<variable initial_value="4.33" name="KmPDCPYR" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="PYR" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vPDC</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmPDC</ci>
<apply>
<power/>
<ci>PYR</ci>
<ci>nPDC</ci>
</apply>
</apply>
<apply>
<power/>
<ci>KmPDCPYR</ci>
<ci>nPDC</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<ci>PYR</ci>
<ci>nPDC</ci>
</apply>
<apply>
<power/>
<ci>KmPDCPYR</ci>
<ci>nPDC</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vSUC">
<variable name="vSUC" public_interface="out" units="mmol_per_min"/>
<variable initial_value="21.4" name="KSUCC" units="per_min"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="ACE" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vSUC</ci>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>KSUCC</ci>
<ci>ACE</ci>
</apply>
</apply>
</math>
</component>
<component name="vADH">
<variable name="vADH" public_interface="out" units="mmol_per_min"/>
<variable initial_value="810" name="VmADH" units="mM_per_min"/>
<variable initial_value="0.92" name="KiADHNAD" units="mM"/>
<variable initial_value="17" name="KmADHETOH" units="mM"/>
<variable initial_value="6.9e-5" name="KeqADH" units="dimensionless"/>
<variable initial_value="0.17" name="KmADHNAD" units="mM"/>
<variable initial_value="0.11" name="KmADHNADH" units="mM"/>
<variable initial_value="0.031" name="KiADHNADH" units="mM"/>
<variable initial_value="1.11" name="KmADHACE" units="mM"/>
<variable initial_value="1.1" name="KiADHACE" units="mM"/>
<variable initial_value="90" name="KiADHETOH" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="ACE" public_interface="in" units="mM"/>
<variable name="ETOH" public_interface="in" units="mM"/>
<variable name="NAD" public_interface="in" units="mM"/>
<variable name="NADH" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vADH</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<apply>
<minus/>
<ci>VmADH</ci>
</apply>
</apply>
<apply>
<times/>
<ci>KiADHNAD</ci>
<ci>KmADHETOH</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>NAD</ci>
<ci>ETOH</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>NADH</ci>
<ci>ACE</ci>
</apply>
<ci>KeqADH</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>NAD</ci>
<ci>KiADHNAD</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>KmADHNAD</ci>
<ci>ETOH</ci>
</apply>
<apply>
<times/>
<ci>KiADHNAD</ci>
<ci>KmADHETOH</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>KmADHNADH</ci>
<ci>ACE</ci>
</apply>
<apply>
<times/>
<ci>KiADHNADH</ci>
<ci>KmADHACE</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>NADH</ci>
<ci>KiADHNADH</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>NAD</ci>
<ci>ETOH</ci>
</apply>
<apply>
<times/>
<ci>KiADHNAD</ci>
<ci>KmADHETOH</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>KmADHNADH</ci>
<ci>NAD</ci>
<ci>ACE</ci>
</apply>
<apply>
<times/>
<ci>KiADHNAD</ci>
<ci>KiADHNADH</ci>
<ci>KmADHACE</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>KmADHNAD</ci>
<ci>ETOH</ci>
<ci>NADH</ci>
</apply>
<apply>
<times/>
<ci>KiADHNAD</ci>
<ci>KmADHETOH</ci>
<ci>KiADHNADH</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>NADH</ci>
<ci>ACE</ci>
</apply>
<apply>
<times/>
<ci>KiADHNADH</ci>
<ci>KmADHACE</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>NAD</ci>
<ci>ETOH</ci>
<ci>ACE</ci>
</apply>
<apply>
<times/>
<ci>KiADHNAD</ci>
<ci>KmADHETOH</ci>
<ci>KiADHACE</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>ETOH</ci>
<ci>NADH</ci>
<ci>ACE</ci>
</apply>
<apply>
<times/>
<ci>KiADHETOH</ci>
<ci>KiADHNADH</ci>
<ci>KmADHACE</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vATP">
<variable name="vATP" public_interface="out" units="mmol_per_min"/>
<variable initial_value="39.5" name="KATPASE" units="per_min"/>
<variable initial_value="0.45" name="KeqAK" units="dimensionless"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="P" public_interface="in" units="mM"/>
<variable name="SUMAXP" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vATP</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>KATPASE</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>P</ci>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<ci>P</ci>
</apply>
</apply>
<ci>SUMAXP</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>KeqAK</ci>
<apply>
<power/>
<ci>P</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
<ci>P</ci>
<ci>SUMAXP</ci>
</apply>
<apply>
<power/>
<ci>SUMAXP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">8</cn>
<ci>KeqAK</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vTPI">
<variable name="vTPI" public_interface="out" units="mmol_per_min"/>
<variable initial_value="1.27" name="KmGA3P" units="mM"/>
<variable initial_value="1.23" name="KmDHAP" units="mM"/>
<variable initial_value="10900" name="VmDHAP" units="mM_per_min"/>
<variable initial_value="555" name="VmGA3P" units="mM_per_min"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="DHAP" public_interface="in" units="mM"/>
<variable name="GA3P" public_interface="in" units="mM"/>
<variable name="k_rel_TPI" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vTPI</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>k_rel_TPI</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>VmDHAP</ci>
<ci>GA3P</ci>
</apply>
<ci>KmGA3P</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>VmGA3P</ci>
<ci>DHAP</ci>
</apply>
<ci>KmDHAP</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>GA3P</ci>
<ci>KmGA3P</ci>
</apply>
<apply>
<divide/>
<ci>DHAP</ci>
<ci>KmDHAP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vG6PDH">
<variable name="vG6PDH" public_interface="out" units="mmol_per_min"/>
<variable initial_value="4" name="VmG6PDH" units="mM_per_min"/>
<variable initial_value="0.04" name="KmG6P" units="mM"/>
<variable initial_value="0.02" name="KmNADP" units="mM"/>
<variable initial_value="0.017" name="KiNADPH" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="G6P" public_interface="in" units="mM"/>
<variable name="NADP" public_interface="in" units="mM"/>
<variable name="NADPH" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vG6PDH</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmG6PDH</ci>
<ci>G6P</ci>
<ci>NADP</ci>
</apply>
<apply>
<times/>
<ci>KmG6P</ci>
<ci>KmNADP</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>G6P</ci>
<ci>KmG6P</ci>
</apply>
<apply>
<divide/>
<ci>NADPH</ci>
<ci>KiNADPH</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>NADP</ci>
<ci>KmNADP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v6PGL">
<variable name="v6PGL" public_interface="out" units="mmol_per_min"/>
<variable initial_value="4" name="Vm6PGL" units="mM_per_min"/>
<variable initial_value="0.8" name="Km6PGL" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="D6PGluconoLactone" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>v6PGL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>Vm6PGL</ci>
<ci>D6PGluconoLactone</ci>
</apply>
<apply>
<plus/>
<ci>Km6PGL</ci>
<ci>D6PGluconoLactone</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vGluDH">
<variable name="vGluDH" public_interface="out" units="mmol_per_min"/>
<variable initial_value="4" name="VmGluDH" units="mM_per_min"/>
<variable initial_value="0.02" name="KmGluconate" units="mM"/>
<variable initial_value="0.03" name="KmNADP" units="mM"/>
<variable initial_value="0.03" name="KiNADPH" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="D6PGluconate" public_interface="in" units="mM"/>
<variable name="NADP" public_interface="in" units="mM"/>
<variable name="NADPH" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vGluDH</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmGluDH</ci>
<ci>D6PGluconate</ci>
<ci>NADP</ci>
</apply>
<apply>
<times/>
<ci>KmGluconate</ci>
<ci>KmNADP</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>D6PGluconate</ci>
<ci>KmGluconate</ci>
</apply>
<apply>
<divide/>
<ci>NADPH</ci>
<ci>KiNADPH</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>NADP</ci>
<ci>KmNADP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vPPI">
<variable name="vPPI" public_interface="out" units="mmol_per_min"/>
<variable initial_value="3458" name="VmPPIf" units="mM_per_min"/>
<variable initial_value="3458" name="VmPPIr" units="mM_per_min"/>
<variable initial_value="1.6" name="KmRibu5P" units="mM"/>
<variable initial_value="1.6" name="KmRibo5P" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="Ribulose5P" public_interface="in" units="mM"/>
<variable name="Ribose5P" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vPPI</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>VmPPIf</ci>
<ci>Ribulose5P</ci>
</apply>
<ci>KmRibu5P</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>VmPPIr</ci>
<ci>Ribose5P</ci>
</apply>
<ci>KmRibo5P</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ribulose5P</ci>
<ci>KmRibu5P</ci>
</apply>
<apply>
<divide/>
<ci>Ribose5P</ci>
<ci>KmRibo5P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vTransk1">
<variable name="vTransk1" public_interface="out" units="mmol_per_min"/>
<variable initial_value="4" name="VmTransk1f" units="mM_per_min"/>
<variable initial_value="2" name="VmTransk1r" units="mM_per_min"/>
<variable initial_value="0.1" name="KmRibose5P" units="mM"/>
<variable initial_value="0.15" name="KmXyl5P" units="mM"/>
<variable initial_value="0.1" name="KmGA3P" units="mM"/>
<variable initial_value="0.15" name="KmSeduhept" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="GA3P" public_interface="in" units="mM"/>
<variable name="Ribose5P" public_interface="in" units="mM"/>
<variable name="Seduhept7P" public_interface="in" units="mM"/>
<variable name="Xyl5P" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vTransk1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>VmTransk1f</ci>
<ci>Ribose5P</ci>
<ci>Xyl5P</ci>
</apply>
<apply>
<times/>
<ci>KmRibose5P</ci>
<ci>KmXyl5P</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>VmTransk1r</ci>
<ci>GA3P</ci>
<ci>Seduhept7P</ci>
</apply>
<apply>
<times/>
<ci>KmGA3P</ci>
<ci>KmSeduhept</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ribose5P</ci>
<ci>KmRibose5P</ci>
</apply>
<apply>
<divide/>
<ci>GA3P</ci>
<ci>KmGA3P</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Xyl5P</ci>
<ci>KmXyl5P</ci>
</apply>
<apply>
<divide/>
<ci>Seduhept7P</ci>
<ci>KmSeduhept</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vR5PI">
<variable name="vR5PI" public_interface="out" units="mmol_per_min"/>
<variable initial_value="1039" name="VmR5PIf" units="mM_per_min"/>
<variable initial_value="1039" name="VmR5PIr" units="mM_per_min"/>
<variable initial_value="1.5" name="KmRibu5P" units="mM"/>
<variable initial_value="1.5" name="KmXyl" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="Ribulose5P" public_interface="in" units="mM"/>
<variable name="Xyl5P" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vR5PI</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>VmR5PIf</ci>
<ci>Ribulose5P</ci>
</apply>
<ci>KmRibu5P</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>VmR5PIr</ci>
<ci>Xyl5P</ci>
</apply>
<ci>KmXyl</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ribulose5P</ci>
<ci>KmRibu5P</ci>
</apply>
<apply>
<divide/>
<ci>Xyl5P</ci>
<ci>KmXyl</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vTransald">
<variable name="vTransald" public_interface="out" units="mmol_per_min"/>
<variable initial_value="55" name="VmTransaldf" units="mM_per_min"/>
<variable initial_value="10" name="VmTransaldr" units="mM_per_min"/>
<variable initial_value="0.22" name="KmGA3P" units="mM"/>
<variable initial_value="0.18" name="KmSeduhept" units="mM"/>
<variable initial_value="0.32" name="KmF6P" units="mM"/>
<variable initial_value="0.018" name="KmEry4P" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="Erythrose4P" public_interface="in" units="mM"/>
<variable name="F6P" public_interface="in" units="mM"/>
<variable name="Seduhept7P" public_interface="in" units="mM"/>
<variable name="GA3P" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vTransald</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>VmTransaldf</ci>
<ci>GA3P</ci>
<ci>Seduhept7P</ci>
</apply>
<apply>
<times/>
<ci>KmGA3P</ci>
<ci>KmSeduhept</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>VmTransaldr</ci>
<ci>F6P</ci>
<ci>Erythrose4P</ci>
</apply>
<apply>
<times/>
<ci>KmF6P</ci>
<ci>KmEry4P</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>GA3P</ci>
<ci>KmGA3P</ci>
</apply>
<apply>
<divide/>
<ci>F6P</ci>
<ci>KmF6P</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Seduhept7P</ci>
<ci>KmSeduhept</ci>
</apply>
<apply>
<divide/>
<ci>Erythrose4P</ci>
<ci>KmEry4P</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vTransk2">
<variable name="vTransk2" public_interface="out" units="mmol_per_min"/>
<variable initial_value="3.2" name="VmTransk2f" units="mM_per_min"/>
<variable initial_value="43" name="VmTransk2r" units="mM_per_min"/>
<variable initial_value="0.16" name="KmXyl5P" units="mM"/>
<variable initial_value="0.09" name="KmEry4P" units="mM"/>
<variable initial_value="1.1" name="KmF6P" units="mM"/>
<variable initial_value="2.1" name="KmGA3P" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="Erythrose4P" public_interface="in" units="mM"/>
<variable name="F6P" public_interface="in" units="mM"/>
<variable name="Xyl5P" public_interface="in" units="mM"/>
<variable name="GA3P" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vTransk2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>VmTransk2f</ci>
<ci>Erythrose4P</ci>
<ci>Xyl5P</ci>
</apply>
<apply>
<times/>
<ci>KmEry4P</ci>
<ci>KmXyl5P</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>VmTransk2r</ci>
<ci>F6P</ci>
<ci>GA3P</ci>
</apply>
<apply>
<times/>
<ci>KmF6P</ci>
<ci>KmGA3P</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Xyl5P</ci>
<ci>KmXyl5P</ci>
</apply>
<apply>
<divide/>
<ci>GA3P</ci>
<ci>KmGA3P</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Erythrose4P</ci>
<ci>KmEry4P</ci>
</apply>
<apply>
<divide/>
<ci>F6P</ci>
<ci>KmF6P</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="vNADPH">
<variable name="vNADPH" public_interface="out" units="mmol_per_min"/>
<variable initial_value="2" name="kNADPH" units="per_min"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="NADPH" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vNADPH</ci>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>kNADPH</ci>
<ci>NADPH</ci>
</apply>
</apply>
</math>
</component>
<component name="vGLT">
<variable name="vGLT" public_interface="out" units="mmol_per_min"/>
<variable initial_value="97.264" name="VmGLT" units="mM_per_min"/>
<variable initial_value="1" name="KeqGLT" units="dimensionless"/>
<variable initial_value="1.1918" name="KmGLTGLCo" units="mM"/>
<variable initial_value="1.1918" name="KmGLTGLCi" units="mM"/>
<variable name="cytoplasm" public_interface="in" units="liter"/>
<variable name="GLCi" public_interface="in" units="mM"/>
<variable name="GLCo" public_interface="in" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>vGLT</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>cytoplasm</ci>
<ci>VmGLT</ci>
<apply>
<minus/>
<ci>GLCo</ci>
<apply>
<divide/>
<ci>GLCi</ci>
<ci>KeqGLT</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>KmGLTGLCo</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>GLCo</ci>
<ci>KmGLTGLCo</ci>
</apply>
<apply>
<divide/>
<ci>GLCi</ci>
<ci>KmGLTGLCi</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.91</cn>
<ci>GLCo</ci>
<ci>GLCi</ci>
</apply>
<apply>
<times/>
<ci>KmGLTGLCi</ci>
<ci>KmGLTGLCo</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="cytoplasm"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="vGLK"/>
<map_variables variable_1="SUMAXP" variable_2="SUMAXP"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="vPFK"/>
<map_variables variable_1="SUMAXP" variable_2="SUMAXP"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="vGAPDH"/>
<map_variables variable_1="k_rel_GAPDH" variable_2="k_rel_GAPDH"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="vPGK"/>
<map_variables variable_1="SUMAXP" variable_2="SUMAXP"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="vPYK"/>
<map_variables variable_1="SUMAXP" variable_2="SUMAXP"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="vATP"/>
<map_variables variable_1="SUMAXP" variable_2="SUMAXP"/>
</connection>
<connection>
<map_components component_1="parameters" component_2="vTPI"/>
<map_variables variable_1="k_rel_TPI" variable_2="k_rel_TPI"/>
</connection>
<connection>
<map_components component_1="rules" component_2="cytoplasm"/>
<map_variables variable_1="NADP" variable_2="NADP"/>
<map_variables variable_1="NADPH" variable_2="NADPH"/>
</connection>
<connection>
<map_components component_1="vGLK" component_2="cytoplasm"/>
<map_variables variable_1="vGLK" variable_2="vGLK"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="G6P" variable_2="G6P"/>
<map_variables variable_1="GLCi" variable_2="GLCi"/>
<map_variables variable_1="P" variable_2="P"/>
</connection>
<connection>
<map_components component_1="vPGI" component_2="cytoplasm"/>
<map_variables variable_1="vPGI" variable_2="vPGI"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="G6P" variable_2="G6P"/>
<map_variables variable_1="F6P" variable_2="F6P"/>
</connection>
<connection>
<map_components component_1="vPFK" component_2="cytoplasm"/>
<map_variables variable_1="vPFK" variable_2="vPFK"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="F16P" variable_2="F16P"/>
<map_variables variable_1="F26BP" variable_2="F26BP"/>
<map_variables variable_1="F6P" variable_2="F6P"/>
<map_variables variable_1="P" variable_2="P"/>
<map_variables variable_1="DHAP" variable_2="DHAP"/>
</connection>
<connection>
<map_components component_1="vALD" component_2="cytoplasm"/>
<map_variables variable_1="vALD" variable_2="vALD"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="F16P" variable_2="F16P"/>
<map_variables variable_1="GA3P" variable_2="GA3P"/>
<map_variables variable_1="DHAP" variable_2="DHAP"/>
</connection>
<connection>
<map_components component_1="vG3PDH" component_2="cytoplasm"/>
<map_variables variable_1="vG3PDH" variable_2="vG3PDH"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="NAD" variable_2="NAD"/>
<map_variables variable_1="NADH" variable_2="NADH"/>
<map_variables variable_1="DHAP" variable_2="DHAP"/>
</connection>
<connection>
<map_components component_1="vG3PDH" component_2="extracellular"/>
<map_variables variable_1="GLY" variable_2="GLY"/>
</connection>
<connection>
<map_components component_1="vGAPDH" component_2="cytoplasm"/>
<map_variables variable_1="vGAPDH" variable_2="vGAPDH"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="BPG" variable_2="BPG"/>
<map_variables variable_1="GA3P" variable_2="GA3P"/>
<map_variables variable_1="NAD" variable_2="NAD"/>
<map_variables variable_1="NADH" variable_2="NADH"/>
</connection>
<connection>
<map_components component_1="vPGK" component_2="cytoplasm"/>
<map_variables variable_1="vPGK" variable_2="vPGK"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="BPG" variable_2="BPG"/>
<map_variables variable_1="P" variable_2="P"/>
<map_variables variable_1="P3G" variable_2="P3G"/>
</connection>
<connection>
<map_components component_1="vPGM" component_2="cytoplasm"/>
<map_variables variable_1="vPGM" variable_2="vPGM"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="P2G" variable_2="P2G"/>
<map_variables variable_1="P3G" variable_2="P3G"/>
</connection>
<connection>
<map_components component_1="vENO" component_2="cytoplasm"/>
<map_variables variable_1="vENO" variable_2="vENO"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="P2G" variable_2="P2G"/>
<map_variables variable_1="PEP" variable_2="PEP"/>
</connection>
<connection>
<map_components component_1="vPYK" component_2="cytoplasm"/>
<map_variables variable_1="vPYK" variable_2="vPYK"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="PEP" variable_2="PEP"/>
<map_variables variable_1="P" variable_2="P"/>
<map_variables variable_1="PYR" variable_2="PYR"/>
</connection>
<connection>
<map_components component_1="vPDC" component_2="cytoplasm"/>
<map_variables variable_1="vPDC" variable_2="vPDC"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="PYR" variable_2="PYR"/>
</connection>
<connection>
<map_components component_1="vSUC" component_2="cytoplasm"/>
<map_variables variable_1="vSUC" variable_2="vSUC"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="ACE" variable_2="ACE"/>
</connection>
<connection>
<map_components component_1="vADH" component_2="cytoplasm"/>
<map_variables variable_1="vADH" variable_2="vADH"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="ACE" variable_2="ACE"/>
<map_variables variable_1="NAD" variable_2="NAD"/>
<map_variables variable_1="NADH" variable_2="NADH"/>
</connection>
<connection>
<map_components component_1="vADH" component_2="extracellular"/>
<map_variables variable_1="ETOH" variable_2="ETOH"/>
</connection>
<connection>
<map_components component_1="vATP" component_2="cytoplasm"/>
<map_variables variable_1="vATP" variable_2="vATP"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="P" variable_2="P"/>
</connection>
<connection>
<map_components component_1="vTPI" component_2="cytoplasm"/>
<map_variables variable_1="vTPI" variable_2="vTPI"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="DHAP" variable_2="DHAP"/>
<map_variables variable_1="GA3P" variable_2="GA3P"/>
</connection>
<connection>
<map_components component_1="vG6PDH" component_2="cytoplasm"/>
<map_variables variable_1="vG6PDH" variable_2="vG6PDH"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="G6P" variable_2="G6P"/>
<map_variables variable_1="NADP" variable_2="NADP"/>
<map_variables variable_1="NADPH" variable_2="NADPH"/>
</connection>
<connection>
<map_components component_1="v6PGL" component_2="cytoplasm"/>
<map_variables variable_1="v6PGL" variable_2="v6PGL"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="D6PGluconoLactone" variable_2="D6PGluconoLactone"/>
</connection>
<connection>
<map_components component_1="vGluDH" component_2="cytoplasm"/>
<map_variables variable_1="vGluDH" variable_2="vGluDH"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="D6PGluconate" variable_2="D6PGluconate"/>
<map_variables variable_1="NADP" variable_2="NADP"/>
<map_variables variable_1="NADPH" variable_2="NADPH"/>
</connection>
<connection>
<map_components component_1="vPPI" component_2="cytoplasm"/>
<map_variables variable_1="vPPI" variable_2="vPPI"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="Ribulose5P" variable_2="Ribulose5P"/>
<map_variables variable_1="Ribose5P" variable_2="Ribose5P"/>
</connection>
<connection>
<map_components component_1="vTransk1" component_2="cytoplasm"/>
<map_variables variable_1="vTransk1" variable_2="vTransk1"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="GA3P" variable_2="GA3P"/>
<map_variables variable_1="Ribose5P" variable_2="Ribose5P"/>
<map_variables variable_1="Seduhept7P" variable_2="Seduhept7P"/>
<map_variables variable_1="Xyl5P" variable_2="Xyl5P"/>
</connection>
<connection>
<map_components component_1="vR5PI" component_2="cytoplasm"/>
<map_variables variable_1="vR5PI" variable_2="vR5PI"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="Ribulose5P" variable_2="Ribulose5P"/>
<map_variables variable_1="Xyl5P" variable_2="Xyl5P"/>
</connection>
<connection>
<map_components component_1="vTransald" component_2="cytoplasm"/>
<map_variables variable_1="vTransald" variable_2="vTransald"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="Erythrose4P" variable_2="Erythrose4P"/>
<map_variables variable_1="F6P" variable_2="F6P"/>
<map_variables variable_1="Seduhept7P" variable_2="Seduhept7P"/>
<map_variables variable_1="GA3P" variable_2="GA3P"/>
</connection>
<connection>
<map_components component_1="vTransk2" component_2="cytoplasm"/>
<map_variables variable_1="vTransk2" variable_2="vTransk2"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="Erythrose4P" variable_2="Erythrose4P"/>
<map_variables variable_1="F6P" variable_2="F6P"/>
<map_variables variable_1="Xyl5P" variable_2="Xyl5P"/>
<map_variables variable_1="GA3P" variable_2="GA3P"/>
</connection>
<connection>
<map_components component_1="vNADPH" component_2="cytoplasm"/>
<map_variables variable_1="vNADPH" variable_2="vNADPH"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="NADPH" variable_2="NADPH"/>
</connection>
<connection>
<map_components component_1="vGLT" component_2="cytoplasm"/>
<map_variables variable_1="vGLT" variable_2="vGLT"/>
<map_variables variable_1="cytoplasm" variable_2="cytoplasm"/>
<map_variables variable_1="GLCi" variable_2="GLCi"/>
</connection>
<connection>
<map_components component_1="vGLT" component_2="extracellular"/>
<map_variables variable_1="GLCo" variable_2="GLCo"/>
</connection>
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