Penny
J
Noble
Noble
Penny
J
Note that the missing i_NCX_ds component was added to the dCai/dt rather than the dCads/dt equation in order to achieve balance in the model.
Noble
Penny
134
123
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes.
14(1)
Noble
Penny
J
This version was created by Penny Noble and is known to read into COR. James Lawson fixed an error (19/04/07) that prevented it reading in PCEnv (unsupported predefined operator diff in component intracellular_calcium_concentration. This variant of version 06 is parameterised for the BASIC model, excluding acetylcholine dependent modulation and electromechanical processes.
penny.noble@dpag.ox.ac.uk
Changed stim_end in stimulus protocol from 10.1 to 1,000,000 seconds
2007-09-06T12:57:25+12:00
James Lawson
This file is a CellML description of Noble, Carghese, Kohl and Noble's 1998 extension of their 1991 guinea pig ventricular cell model. This model incorporates a diadic space, IKr and IKs currents, and length and tension dependent processes. Variant 1 is parameterised for the 'basic' model.
To simulate multiple action potentials with this model the following integrator parameters must be used: max step size must be 0.001 or less, max point density must be 10,000 or more.
Richard
Lawson
James
University of Oxford
Department of Physiology, Anatomy & Genetics
Units checked, curated.
9487284
ventricle
guinea-pig
cardiac
0.001
bdf15
100000
Model B: multiple stimuli
Department of Physiology, Anatomy & Genetics, University of Oxford
Noble
P
Department of Physiology, Anatomy & Genetics, University of Oxford
Model A: single stimulus
0.001
50000
Noble
D
2007-02-06T14:05:00+13:00
2007-12-04T15:09:12+13:00
1998-01-01 00:00
This model has been curated by Penny Noble of Oxford University
Several variables have been given cmeta:id's to allow creation of a PCEnv session file.
Penny Noble was informed by a community member that INaCads was not included in the dCads/dt ODE and hence the system was out of balance. This has been fixed in version 07. An alteration was also made to the model to remove two differential expressions in the intracellular_calcium concentration component to allow PCEnv 0.2 to run the model.
A
Varghese
Richard
James
Lawson
guinea-pig
electrophysiology
ventricle
cardiac
James Lawson
keyword
2007-06-22T14:01:50+12:00
Kohl
P
Richard
Lawson
James
2007-07-18T12:58:29+12:00
2008-05-14T03:12:08+12:00
2007-05-03T00:00:00+00:00
Canadian Journal of Cardiology
keyword
electrophysiology