C C There are a total of 0 entries in the algebraic variable array. C There are a total of 10 entries in each of the rate and state variable arrays. C There are a total of 28 entries in the constant variable array. C C C VOI is time in component environment (day). C STATES(1) is T in component uninfected_CD4 (cells_per_mm3). C CONSTS(1) is s in component uninfected_CD4 (cells_per_mm3_day). C CONSTS(2) is lambda in component uninfected_CD4 (per_day). C STATES(2) is T1_star in component productively_infected_CD4 (cells_per_mm3). C STATES(3) is T2_star in component productively_infected_CD4 (cells_per_mm3). C CONSTS(3) is Tmax in component uninfected_CD4 (cells_per_mm3). C CONSTS(4) is mu in component uninfected_CD4 (per_day). C CONSTS(5) is k1 in component productively_infected_CD4 (ml_per_virons_day). C CONSTS(6) is r1 in component drug_parameters (dimensionless). C STATES(4) is V1_I in component virus_strain1 (virons_per_ml). C CONSTS(7) is k2 in component productively_infected_CD4 (ml_per_virons_day). C CONSTS(8) is r2 in component drug_parameters (dimensionless). C STATES(5) is V2_I in component virus_strain2 (virons_per_ml). C STATES(6) is M in component uninfected_long_lived_cells (cells_per_mm3). C CONSTS(9) is lambda_M in component uninfected_long_lived_cells (cells_per_mm3_day). C CONSTS(10) is mu_M in component uninfected_long_lived_cells (per_day). C CONSTS(11) is k1_M in component productively_infected_long_lived_cells (ml_per_virons_day). C CONSTS(12) is k2_M in component productively_infected_long_lived_cells (ml_per_virons_day). C CONSTS(13) is m11 in component productively_infected_CD4 (dimensionless). C CONSTS(14) is m21 in component productively_infected_CD4 (dimensionless). C CONSTS(15) is delta1 in component productively_infected_CD4 (per_day). C CONSTS(16) is m22 in component productively_infected_CD4 (dimensionless). C CONSTS(17) is m12 in component productively_infected_CD4 (dimensionless). C CONSTS(18) is delta2 in component productively_infected_CD4 (per_day). C STATES(7) is M1_star in component productively_infected_long_lived_cells (cells_per_mm3). C CONSTS(19) is delta1_M in component productively_infected_long_lived_cells (per_day). C STATES(8) is M2_star in component productively_infected_long_lived_cells (cells_per_mm3). C CONSTS(20) is delta2_M in component productively_infected_long_lived_cells (per_day). C CONSTS(21) is p1 in component drug_parameters (dimensionless). C CONSTS(22) is N1 in component virus_strain1 (virons_per_cell). C CONSTS(23) is N1_M in component virus_strain1 (virons_per_cell). C STATES(9) is V1 in component virus_strain1 (virons_per_ml). C CONSTS(24) is c1 in component virus_strain1 (per_day). C CONSTS(25) is p2 in component drug_parameters (dimensionless). C CONSTS(26) is N2 in component virus_strain2 (virons_per_cell). C CONSTS(27) is N2_M in component virus_strain2 (virons_per_cell). C CONSTS(28) is c2 in component virus_strain2 (per_day). C STATES(10) is V2 in component virus_strain2 (virons_per_ml). C RATES(1) is d/dt T in component uninfected_CD4 (cells_per_mm3). C RATES(6) is d/dt M in component uninfected_long_lived_cells (cells_per_mm3). C RATES(2) is d/dt T1_star in component productively_infected_CD4 (cells_per_mm3). C RATES(3) is d/dt T2_star in component productively_infected_CD4 (cells_per_mm3). C RATES(7) is d/dt M1_star in component productively_infected_long_lived_cells (cells_per_mm3). C RATES(8) is d/dt M2_star in component productively_infected_long_lived_cells (cells_per_mm3). C RATES(4) is d/dt V1_I in component virus_strain1 (virons_per_ml). C RATES(9) is d/dt V1 in component virus_strain1 (virons_per_ml). C RATES(5) is d/dt V2_I in component virus_strain2 (virons_per_ml). C RATES(10) is d/dt V2 in component virus_strain2 (virons_per_ml). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 178.81 CONSTS(1) = 0 CONSTS(2) = 0.01 STATES(2) = 1.19 STATES(3) = 0.004 CONSTS(3) = 450 CONSTS(4) = 0.0014 CONSTS(5) = 3.43E-8 CONSTS(6) = 0.9 STATES(4) = 133500 CONSTS(7) = 3.43E-8 CONSTS(8) = 0.25 STATES(5) = 450 STATES(6) = 49.2 CONSTS(9) = 2.0 CONSTS(10) = 0.04 CONSTS(11) = 4.67E-9 CONSTS(12) = 4.67E-9 CONSTS(13) = 1 CONSTS(14) = 3.4E-5 CONSTS(15) = 0.69 CONSTS(16) = 1 CONSTS(17) = 3.4E-5 CONSTS(18) = 0.69 STATES(7) = 0.49 CONSTS(19) = 0.062 STATES(8) = 1.7E-3 CONSTS(20) = 0.062 CONSTS(21) = 0.99 CONSTS(22) = 480.1 CONSTS(23) = 534.4 STATES(9) = 133500 CONSTS(24) = 3.07 CONSTS(25) = 0.25 CONSTS(26) = 475.3 CONSTS(27) = 529.0 CONSTS(28) = 3.07 STATES(10) = 450 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = (((CONSTS(1)+ CONSTS(2)*STATES(1)*(1.00000 - (STATES(1)+STATES(2)+STATES(3))/CONSTS(3))) - CONSTS(4)*STATES(1)) - CONSTS(5)*(1.00000 - CONSTS(6))*STATES(1)*STATES(4)) - CONSTS(7)*(1.00000 - CONSTS(8))*STATES(1)*STATES(5) RATES(6) = ((CONSTS(9) - CONSTS(10)*STATES(6)) - CONSTS(11)*(1.00000 - CONSTS(6))*STATES(6)*STATES(4)) - CONSTS(12)*(1.00000 - CONSTS(8))*STATES(6)*STATES(5) RATES(2) = ( CONSTS(13)*CONSTS(5)*(1.00000 - CONSTS(6))*STATES(1)*STATES(4)+ CONSTS(14)*CONSTS(7)*(1.00000 - CONSTS(8))*STATES(1)*STATES(5)) - CONSTS(15)*STATES(2) RATES(3) = ( CONSTS(16)*CONSTS(7)*(1.00000 - CONSTS(8))*STATES(1)*STATES(5)+ CONSTS(17)*CONSTS(5)*(1.00000 - CONSTS(6))*STATES(1)*STATES(4)) - CONSTS(18)*STATES(3) RATES(7) = ( CONSTS(13)*CONSTS(11)*(1.00000 - CONSTS(6))*STATES(6)*STATES(4)+ CONSTS(14)*CONSTS(12)*(1.00000 - CONSTS(8))*STATES(6)*STATES(5)) - CONSTS(19)*STATES(7) RATES(8) = ( CONSTS(16)*CONSTS(12)*(1.00000 - CONSTS(8))*STATES(6)*STATES(5)+ CONSTS(17)*CONSTS(11)*(1.00000 - CONSTS(6))*STATES(6)*STATES(4)) - CONSTS(20)*STATES(8) RATES(4) = ( (1.00000 - CONSTS(21))*CONSTS(22)*CONSTS(15)*STATES(2)+ (1.00000 - CONSTS(21))*CONSTS(23)*CONSTS(19)*STATES(7)) - CONSTS(24)*STATES(4) RATES(9) = ( CONSTS(22)*CONSTS(15)*STATES(2)+ CONSTS(23)*CONSTS(19)*STATES(7)) - CONSTS(24)*STATES(9) RATES(5) = ( (1.00000 - CONSTS(25))*CONSTS(26)*CONSTS(18)*STATES(3)+ (1.00000 - CONSTS(25))*CONSTS(27)*CONSTS(20)*STATES(8)) - CONSTS(28)*STATES(5) RATES(10) = ( CONSTS(26)*CONSTS(18)*STATES(3)+ CONSTS(27)*CONSTS(20)*STATES(8)) - CONSTS(28)*STATES(10) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RETURN END