C C There are a total of 5 entries in the algebraic variable array. C There are a total of 7 entries in each of the rate and state variable arrays. C There are a total of 34 entries in the constant variable array. C C C VOI is time in component environment (day). C STATES(1) is phi_I in component phi_I (cells_per_mm3). C ALGBRC(4) is alpha in component model_parameters (dimensionless). C CONSTS(1) is k1 in component model_parameters (dimensionless). C CONSTS(2) is k2 in component model_parameters (per_day). C CONSTS(3) is k3 in component model_parameters (mm3_per_cells). C CONSTS(4) is k5 in component model_parameters (mm3_per_cells). C CONSTS(5) is k6 in component model_parameters (mm3_per_microg). C CONSTS(6) is d1 in component model_parameters (per_day). C STATES(2) is phi_R in component phi_R (cells_per_mm3). C ALGBRC(1) is K_T in component K_T (cells_per_mm3_per_day). C STATES(3) is F in component F (cells_per_mm3). C STATES(4) is C in component C (microg_per_mm3). C STATES(5) is T in component T (pg_per_mm3). C CONSTS(7) is k4 in component model_parameters (pg_per_cells_per_day). C CONSTS(8) is k7 in component model_parameters (pg_per_cells_per_day). C CONSTS(9) is d2 in component model_parameters (per_day). C STATES(6) is P in component P (pg_per_mm3). C CONSTS(10) is k8 in component model_parameters (pg_per_cells_per_day). C CONSTS(11) is k9 in component model_parameters (pg_per_cells_per_day). C CONSTS(12) is d3 in component model_parameters (per_day). C CONSTS(13) is k10 in component model_parameters (per_day). C CONSTS(14) is d4 in component model_parameters (per_day). C ALGBRC(2) is M_P in component M_P (cells_per_mm3_per_day). C CONSTS(15) is k11 in component model_parameters (microg_per_cells_per_day). C ALGBRC(3) is f_T in component f_T (dimensionless). C ALGBRC(5) is g_C in component g_C (dimensionless). C CONSTS(16) is d5 in component model_parameters (mm3_per_cells_per_day). C STATES(7) is H in component H (microg_per_mm3). C CONSTS(17) is k12 in component model_parameters (microg_per_cells_per_day). C CONSTS(18) is d6 in component model_parameters (per_day). C CONSTS(19) is tau1 in component K_T (mm6_cells_per_pg3_day). C CONSTS(20) is tau2 in component K_T (mm3_cells_per_pg2_day). C CONSTS(21) is tau3 in component K_T (cells_per_pg_per_day). C CONSTS(22) is tau4 in component K_T (cells_per_mm3_per_day). C CONSTS(23) is tau1 in component M_P (mm6_cells_per_pg3_day). C CONSTS(24) is tau2 in component M_P (mm3_cells_per_pg2_day). C CONSTS(25) is tau3 in component M_P (cells_per_pg_per_day). C CONSTS(26) is tau4 in component M_P (cells_per_mm3_per_day). C CONSTS(27) is tau1 in component f_T (mm9_per_pg3). C CONSTS(28) is tau2 in component f_T (mm6_per_pg2). C CONSTS(29) is tau3 in component f_T (mm3_per_pg). C CONSTS(30) is tau4 in component f_T (dimensionless). C CONSTS(31) is tau1 in component g_C (mm9_per_microg3). C CONSTS(32) is tau2 in component g_C (mm6_per_microg2). C CONSTS(33) is tau3 in component g_C (mm3_per_microg). C CONSTS(34) is tau4 in component g_C (dimensionless). C RATES(1) is d/dt phi_I in component phi_I (cells_per_mm3). C RATES(2) is d/dt phi_R in component phi_R (cells_per_mm3). C RATES(5) is d/dt T in component T (pg_per_mm3). C RATES(6) is d/dt P in component P (pg_per_mm3). C RATES(3) is d/dt F in component F (cells_per_mm3). C RATES(4) is d/dt C in component C (microg_per_mm3). C RATES(7) is d/dt H in component H (microg_per_mm3). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 200.0 CONSTS(1) = 0.05 CONSTS(2) = 0.693 CONSTS(3) = 0.002 CONSTS(4) = 0.0025 CONSTS(5) = 0.0004 CONSTS(6) = 0.2 STATES(2) = 200.0 STATES(3) = 50.0 STATES(4) = 10.0 STATES(5) = 6.0 CONSTS(7) = 0.07 CONSTS(8) = 0.004 CONSTS(9) = 9.1 STATES(6) = 2.0 CONSTS(10) = 0.015 CONSTS(11) = 0.0015 CONSTS(12) = 4.0 CONSTS(13) = 0.924 CONSTS(14) = 2.5 CONSTS(15) = 5.0 CONSTS(16) = 1.5E-5 STATES(7) = 0.01 CONSTS(17) = 0.001 CONSTS(18) = 0.7 CONSTS(19) = -2.47 CONSTS(20) = 21.94 CONSTS(21) = 6.41 CONSTS(22) = 1.75 CONSTS(23) = 15.333 CONSTS(24) = -167.21 CONSTS(25) = 452.38 CONSTS(26) = 2.6593 CONSTS(27) = 0.0092 CONSTS(28) = -0.1552 CONSTS(29) = 0.6279 CONSTS(30) = 0.2527 CONSTS(31) = -4.33E-10 CONSTS(32) = 0.0000009 CONSTS(33) = -0.00055 CONSTS(34) = 0.13 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(5) = ( CONSTS(7)*STATES(1)+ CONSTS(8)*STATES(3)) - CONSTS(9)*STATES(5) RATES(6) = ( CONSTS(10)*(STATES(1)+STATES(2))+ CONSTS(11)*STATES(3)) - CONSTS(12)*STATES(6) RATES(7) = CONSTS(17)*STATES(3) - CONSTS(18)*STATES(7) ALGBRC(2) = CONSTS(23)*STATES(6) ** 3.00000+ CONSTS(24)*STATES(6) ** 2.00000+ CONSTS(25)*STATES(6)+CONSTS(26) RATES(3) = (ALGBRC(2)+ CONSTS(13)*STATES(3)*(1.00000 - ( CONSTS(3)*(STATES(1)+STATES(2))+ CONSTS(4)*STATES(3)+ CONSTS(5)*STATES(4)))) - CONSTS(14)*STATES(3) ALGBRC(4) = - ( 0.197000*arbitrary_log(STATES(7), 10))+0.440700 ALGBRC(1) = CONSTS(19)*STATES(5) ** 3.00000+ CONSTS(20)*STATES(5) ** 2.00000+ CONSTS(21)*STATES(5)+CONSTS(22) RATES(1) = ( ALGBRC(4)*ALGBRC(1)+ CONSTS(1)*CONSTS(2)*STATES(1)*(1.00000 - ( CONSTS(3)*(STATES(1)+STATES(2))+ CONSTS(4)*STATES(3)+ CONSTS(5)*STATES(4)))) - CONSTS(6)*STATES(1) RATES(2) = ( (1.00000 - ALGBRC(4))*ALGBRC(1)+ CONSTS(1)*CONSTS(2)*STATES(2)*(1.00000 - ( CONSTS(3)*(STATES(1)+STATES(2))+ CONSTS(4)*STATES(3)+ CONSTS(5)*STATES(4)))) - CONSTS(6)*STATES(2) ALGBRC(3) = CONSTS(27)*STATES(5) ** 3.00000+ CONSTS(28)*STATES(5) ** 2.00000+ CONSTS(29)*STATES(5)+CONSTS(30) ALGBRC(5) = CONSTS(31)*STATES(4) ** 3.00000+ CONSTS(32)*STATES(4) ** 2.00000+ CONSTS(33)*STATES(4)+CONSTS(34) RATES(4) = CONSTS(15)*STATES(3)*ALGBRC(3)*ALGBRC(5) - CONSTS(16)*STATES(3)*STATES(4) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(23)*STATES(6) ** 3.00000+ CONSTS(24)*STATES(6) ** 2.00000+ CONSTS(25)*STATES(6)+CONSTS(26) ALGBRC(4) = - ( 0.197000*arbitrary_log(STATES(7), 10))+0.440700 ALGBRC(1) = CONSTS(19)*STATES(5) ** 3.00000+ CONSTS(20)*STATES(5) ** 2.00000+ CONSTS(21)*STATES(5)+CONSTS(22) ALGBRC(3) = CONSTS(27)*STATES(5) ** 3.00000+ CONSTS(28)*STATES(5) ** 2.00000+ CONSTS(29)*STATES(5)+CONSTS(30) ALGBRC(5) = CONSTS(31)*STATES(4) ** 3.00000+ CONSTS(32)*STATES(4) ** 2.00000+ CONSTS(33)*STATES(4)+CONSTS(34) RETURN END